Bradford Lowell - Publications

Affiliations: 
Harvard Medical School, Boston, MA, United States 
Area:
The neural basis for hunger

162 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Perry RJ, Resch JM, Douglass AM, Madara JC, Rabin-Court A, Kucukdereli H, Wu C, Song JD, Lowell BB, Shulman GI. Leptin's hunger-suppressing effects are mediated by the hypothalamic-pituitary-adrenocortical axis in rodents. Proceedings of the National Academy of Sciences of the United States of America. PMID 31213533 DOI: 10.1073/pnas.1901795116  0.8
2019 Zeng X, Ye M, Resch JM, Jedrychowski MP, Hu B, Lowell BB, Ginty DD, Spiegelman BM. Publisher Correction: Innervation of thermogenic adipose tissue via a calsyntenin 3β-S100b axis. Nature. PMID 31114060 DOI: 10.1038/s41586-019-1267-3  0.44
2019 Zeng X, Ye M, Resch JM, Jedrychowski MP, Hu B, Lowell BB, Ginty DD, Spiegelman BM. Innervation of thermogenic adipose tissue via a calsyntenin 3β-S100b axis. Nature. PMID 31043739 DOI: 10.1038/s41586-019-1156-9  0.44
2019 Li MM, Madara JC, Steger JS, Krashes MJ, Balthasar N, Campbell JN, Resch JM, Conley NJ, Garfield AS, Lowell BB. The Paraventricular Hypothalamus Regulates Satiety and Prevents Obesity via Two Genetically Distinct Circuits. Neuron. PMID 30879785 DOI: 10.1016/j.neuron.2019.02.028  0.8
2018 Machado NLS, Abbott SBG, Resch JM, Zhu L, Arrigoni E, Lowell BB, Fuller PM, Fontes MAP, Saper CB. A Glutamatergic Hypothalamomedullary Circuit Mediates Thermogenesis, but Not Heat Conservation, during Stress-Induced Hyperthermia. Current Biology : Cb. PMID 30017482 DOI: 10.1016/j.cub.2018.05.064  0.88
2018 Ross RA, Leon S, Madara JC, Schafer D, Fergani C, Maguire CA, Verstegen AM, Brengle E, Kong D, Herbison AE, Kaiser UB, Lowell BB, Navarro VM. PACAP neurons in the ventral premammillary nucleus regulate reproductive function in the female mouse. Elife. 7. PMID 29905528 DOI: 10.7554/eLife.35960  0.32
2018 Todd WD, Fenselau H, Wang JL, Zhang R, Machado NL, Venner A, Broadhurst RY, Kaur S, Lynagh T, Olson DP, Lowell BB, Fuller PM, Saper CB. A hypothalamic circuit for the circadian control of aggression. Nature Neuroscience. PMID 29632359 DOI: 10.1038/s41593-018-0126-0  0.88
2017 Resch JM, Fenselau H, Madara JC, Wu C, Campbell JN, Lyubetskaya A, Dawes BA, Tsai LT, Li MM, Livneh Y, Ke Q, Kang PM, Fejes-Tóth G, Náray-Fejes-Tóth A, Geerling JC, ... Lowell BB, et al. Aldosterone-Sensing Neurons in the NTS Exhibit State-Dependent Pacemaker Activity and Drive Sodium Appetite via Synergy with Angiotensin II Signaling. Neuron. 96: 190-206.e7. PMID 28957668 DOI: 10.1016/j.neuron.2017.09.014  0.8
2017 Andermann ML, Lowell BB. Toward a Wiring Diagram Understanding of Appetite Control. Neuron. 95: 757-778. PMID 28817798 DOI: 10.1016/j.neuron.2017.06.014  0.72
2017 Fenselau H, Campbell JN, Verstegen AMJ, Madara JC, Xu J, Shah BP, Resch JM, Yang Z, Mandelblat-Cerf Y, Livneh Y, Lowell BB. Corrigendum: A rapidly acting glutamatergic ARC→PVH satiety circuit postsynaptically regulated by α-MSH. Nature Neuroscience. 20: 1189. PMID 28745725 DOI: 10.1038/nn0817-1189b  0.8
2017 Livneh Y, Ramesh RN, Burgess CR, Levandowski KM, Madara JC, Fenselau H, Goldey GJ, Diaz VE, Jikomes N, Resch JM, Lowell BB, Andermann ML. Homeostatic circuits selectively gate food cue responses in insular cortex. Nature. PMID 28614299 DOI: 10.1038/nature22375  0.8
2017 Mahoney CE, Agostinelli LJ, Brooks JN, Lowell BB, Scammell TE. GABAergic neurons of the central amygdala promote cataplexy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28235898 DOI: 10.1523/JNEUROSCI.4065-15.2017  0.56
2017 Campbell JN, Macosko EZ, Fenselau H, Pers TH, Lyubetskaya A, Tenen D, Goldman M, Verstegen AM, Resch JM, McCarroll SA, Rosen ED, Lowell BB, Tsai LT. A molecular census of arcuate hypothalamus and median eminence cell types. Nature Neuroscience. PMID 28166221 DOI: 10.1038/nn.4495  0.8
2016 Agostinelli LJ, Ferrari LL, Mahoney CE, Mochizuki T, Lowell BB, Arrigoni E, Scammell TE. Descending Projections from the Basal Forebrain to the Orexin Neurons in Mice. The Journal of Comparative Neurology. PMID 27997037 DOI: 10.1002/cne.24158  0.56
2016 Mandelblat-Cerf Y, Kim A, Burgess CR, Subramanian S, Tannous BA, Lowell BB, Andermann ML. Bidirectional Anticipation of Future Osmotic Challenges by Vasopressin Neurons. Neuron. PMID 27989461 DOI: 10.1016/j.neuron.2016.11.021  0.8
2016 Fenselau H, Campbell JN, Verstegen AM, Madara JC, Xu J, Shah BP, Resch JM, Yang Z, Mandelblat-Cerf Y, Livneh Y, Lowell BB. A rapidly acting glutamatergic ARC→PVH satiety circuit postsynaptically regulated by α-MSH. Nature Neuroscience. PMID 27869800 DOI: 10.1038/nn.4442  0.8
2016 Garfield AS, Shah BP, Burgess CR, Li MM, Li C, Steger JS, Madara JC, Campbell JN, Kroeger D, Scammell TE, Tannous BA, Myers MG, Andermann ML, Krashes MJ, Lowell BB. Dynamic GABAergic afferent modulation of AgRP neurons. Nature Neuroscience. PMID 27643429 DOI: 10.1038/nn.4392  0.8
2016 Vetrivelan R, Kong D, Ferrari LL, Arrigoni E, Madara JC, Bandaru S, Lowell BB, Lu J, Saper CB. Melanin-concentrating hormone neurons specifically promote rapid eye movement sleep in mice. Neuroscience. PMID 27595887 DOI: 10.1016/j.neuroscience.2016.08.046  0.56
2016 Burgess CR, Ramesh RN, Sugden AU, Levandowski KM, Minnig MA, Fenselau H, Lowell BB, Andermann ML. Hunger-Dependent Enhancement of Food Cue Responses in Mouse Postrhinal Cortex and Lateral Amygdala. Neuron. PMID 27523426 DOI: 10.1016/j.neuron.2016.07.032  0.8
2016 Kong D, Dagon Y, Campbell JN, Guo Y, Yang Z, Yi X, Aryal P, Wellenstein K, Kahn BB, Sabatini BL, Lowell BB. A Postsynaptic AMPK→p21-Activated Kinase Pathway Drives Fasting-Induced Synaptic Plasticity in AgRP Neurons. Neuron. PMID 27321921 DOI: 10.1016/j.neuron.2016.05.025  0.88
2016 Williams EK, Chang RB, Strochlic DE, Umans BD, Lowell BB, Liberles SD. Sensory Neurons that Detect Stretch and Nutrients in the Digestive System. Cell. PMID 27238020 DOI: 10.1016/j.cell.2016.05.011  0.56
2016 Kondoh K, Lu Z, Ye X, Olson DP, Lowell BB, Buck LB. A specific area of olfactory cortex involved in stress hormone responses to predator odours. Nature. PMID 27001694 DOI: 10.1038/nature17156  0.56
2016 Crowley NA, Bloodgood DW, Hardaway JA, Kendra AM, McCall JG, Al-Hasani R, McCall NM, Yu W, Schools ZL, Krashes MJ, Lowell BB, Whistler JL, Bruchas MR, Kash TL. Dynorphin Controls the Gain of an Amygdalar Anxiety Circuit. Cell Reports. PMID 26997280 DOI: 10.1016/j.celrep.2016.02.069  0.56
2016 D'Agostino G, Lyons DJ, Cristiano C, Burke LK, Madara JC, Campbell JN, Garcia AP, Land BB, Lowell BB, Dileone RJ, Heisler LK. Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit. Elife. 5. PMID 26974347 DOI: 10.7554/eLife.12225  0.56
2016 Nakajima K, Cui Z, Li C, Meister J, Cui Y, Fu O, Smith AS, Jain S, Lowell BB, Krashes MJ, Wess J. Corrigendum: Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake. Nature Communications. 7: 11019. PMID 26936677 DOI: 10.1038/ncomms11019  0.56
2016 Vernia S, Morel C, Madara JC, Cavanagh-Kyros J, Barrett T, Chase K, Kennedy NJ, Jung DY, Kim JK, Aronin N, Flavell RA, Lowell BB, Davis RJ. Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress. Elife. 5. PMID 26910012 DOI: 10.7554/eLife.10031  0.56
2016 Krashes MJ, Lowell BB, Garfield AS. Melanocortin-4 receptor-regulated energy homeostasis. Nature Neuroscience. 19: 206-19. PMID 26814590 DOI: 10.1038/nn.4202  0.56
2016 Nakajima K, Cui Z, Li C, Meister J, Cui Y, Fu O, Smith AS, Jain S, Lowell BB, Krashes MJ, Wess J. Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake. Nature Communications. 7: 10268. PMID 26743492 DOI: 10.1038/ncomms10268  0.56
2016 Krashes MJ, Lowell BB, Garfield AS. Melanocortin-4 receptor-regulated energy homeostasis Nature Neuroscience. 19: 206-219. DOI: 10.1038/nn.4202  0.56
2015 Ferrari LL, Agostinelli LJ, Krashes MJ, Lowell BB, Scammell TE, Arrigoni E. Dynorphin inhibits basal forebrain cholinergic neurons by pre- and post-synaptic mechanisms. The Journal of Physiology. PMID 26613645 DOI: 10.1113/JP271657  0.56
2015 Geerling JC, Kim MY, Mahoney CE, Abbott SB, Agostinelli LJ, Garfield AS, Krashes MJ, Lowell BB, Scammell TE. Genetic identity of thermosensory relay neurons in the lateral parabrachial nucleus. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. ajpregu.00094.2015. PMID 26491097 DOI: 10.1152/ajpregu.00094.2015  0.56
2015 Al-Hasani R, McCall JG, Shin G, Gomez AM, Schmitz GP, Bernardi JM, Pyo CO, Park SI, Marcinkiewcz CM, Crowley NA, Krashes MJ, Lowell BB, Kash TL, Rogers JA, Bruchas MR. Distinct Subpopulations of Nucleus Accumbens Dynorphin Neurons Drive Aversion and Reward. Neuron. 87: 1063-77. PMID 26335648 DOI: 10.1016/j.neuron.2015.08.019  0.56
2015 Mandelblat-Cerf Y, Ramesh RN, Burgess CR, Patella P, Yang Z, Lowell BB, Andermann ML. Arcuate hypothalamic AgRP and putative POMC neurons show opposite changes in spiking across multiple timescales. Elife. 4. PMID 26159614 DOI: 10.7554/eLife.07122  0.88
2015 Garfield AS, Li C, Madara JC, Shah BP, Webber E, Steger JS, Campbell JN, Gavrilova O, Lee CE, Olson DP, Elmquist JK, Tannous BA, Krashes MJ, Lowell BB. A neural basis for melanocortin-4 receptor-regulated appetite. Nature Neuroscience. 18: 863-71. PMID 25915476 DOI: 10.1038/nn.4011  0.88
2015 Allison MB, Patterson CM, Krashes MJ, Lowell BB, Myers MG, Olson DP. TRAP-seq defines markers for novel populations of hypothalamic and brainstem LepRb neurons. Molecular Metabolism. 4: 299-309. PMID 25830093 DOI: 10.1016/j.molmet.2015.01.012  0.88
2015 Pleil KE, Rinker JA, Lowery-Gionta EG, Mazzone CM, McCall NM, Kendra AM, Olson DP, Lowell BB, Grant KA, Thiele TE, Kash TL. NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking. Nature Neuroscience. 18: 545-52. PMID 25751534 DOI: 10.1038/nn.3972  0.88
2014 Garfield AS, Shah BP, Madara JC, Burke LK, Patterson CM, Flak J, Neve RL, Evans ML, Lowell BB, Myers MG, Heisler LK. A parabrachial-hypothalamic cholecystokinin neurocircuit controls counterregulatory responses to hypoglycemia. Cell Metabolism. 20: 1030-7. PMID 25470549 DOI: 10.1016/j.cmet.2014.11.006  0.88
2014 Duan B, Cheng L, Bourane S, Britz O, Padilla C, Garcia-Campmany L, Krashes M, Knowlton W, Velasquez T, Ren X, Ross SE, Lowell BB, Wang Y, Goulding M, Ma Q. Identification of spinal circuits transmitting and gating mechanical pain. Cell. 159: 1417-32. PMID 25467445 DOI: 10.1016/j.cell.2014.11.003  0.88
2014 Saper CB, Lowell BB. The hypothalamus. Current Biology : Cb. 24: R1111-6. PMID 25465326 DOI: 10.1016/j.cub.2014.10.023  0.88
2014 do Carmo JM, da Silva AA, Ebaady SE, Sessums PO, Abraham RS, Elmquist JK, Lowell BB, Hall JE. Shp2 signaling in POMC neurons is important for leptin's actions on blood pressure, energy balance, and glucose regulation. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 307: R1438-47. PMID 25339680 DOI: 10.1152/ajpregu.00131.2014  0.88
2014 Shah BP, Vong L, Olson DP, Koda S, Krashes MJ, Ye C, Yang Z, Fuller PM, Elmquist JK, Lowell BB. MC4R-expressing glutamatergic neurons in the paraventricular hypothalamus regulate feeding and are synaptically connected to the parabrachial nucleus. Proceedings of the National Academy of Sciences of the United States of America. 111: 13193-8. PMID 25157144 DOI: 10.1073/pnas.1407843111  0.88
2014 Berglund ED, Liu T, Kong X, Sohn JW, Vong L, Deng Z, Lee CE, Lee S, Williams KW, Olson DP, Scherer PE, Lowell BB, Elmquist JK. Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia. Nature Neuroscience. 17: 911-3. PMID 24908101 DOI: 10.1038/nn.3737  0.88
2014 Martin C, Navarro VM, Simavli S, Vong L, Carroll RS, Lowell BB, Kaiser UB. Leptin-responsive GABAergic neurons regulate fertility through pathways that result in reduced kisspeptinergic tone. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 6047-56. PMID 24760864 DOI: 10.1523/JNEUROSCI.3003-13.2014  0.88
2014 Krashes MJ, Shah BP, Madara JC, Olson DP, Strochlic DE, Garfield AS, Vong L, Pei H, Watabe-Uchida M, Uchida N, Liberles SD, Lowell BB. An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger. Nature. 507: 238-42. PMID 24487620 DOI: 10.1038/nature12956  0.88
2013 Xu Y, Wu Z, Sun H, Zhu Y, Kim ER, Lowell BB, Arenkiel BR, Xu Y, Tong Q. Glutamate mediates the function of melanocortin receptor 4 on Sim1 neurons in body weight regulation. Cell Metabolism. 18: 860-70. PMID 24315371 DOI: 10.1016/j.cmet.2013.11.003  0.88
2013 Garfield AS, Lowell BB. Was it something I ate? Cell Metabolism. 18: 769-70. PMID 24315365 DOI: 10.1016/j.cmet.2013.11.010  0.88
2013 Krashes MJ, Shah BP, Koda S, Lowell BB. Rapid versus delayed stimulation of feeding by the endogenously released agRP neuron mediators GABA, NPY, and AgRP Cell Metabolism. 18: 588-595. PMID 24093681 DOI: 10.1016/j.cmet.2013.09.009  0.88
2013 Fujikawa T, Berglund ED, Patel VR, Ramadori G, Vianna CR, Vong L, Thorel F, Chera S, Herrera PL, Lowell BB, Elmquist JK, Baldi P, Coppari R. Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin. Cell Metabolism. 18: 431-44. PMID 24011077 DOI: 10.1016/j.cmet.2013.08.004  0.88
2013 Huang H, Lee SH, Ye C, Lima IS, Oh BC, Lowell BB, Zabolotny JM, Kim YB. ROCK1 in AgRP neurons regulates energy expenditure and locomotor activity in male mice. Endocrinology. 154: 3660-70. PMID 23885017 DOI: 10.1210/en.2013-1343  0.88
2013 Xu P, Grueter BA, Britt JK, McDaniel L, Huntington PJ, Hodge R, Tran S, Mason BL, Lee C, Vong L, Lowell BB, Malenka RC, Lutter M, Pieper AA. Double deletion of melanocortin 4 receptors and SAPAP3 corrects compulsive behavior and obesity in mice. Proceedings of the National Academy of Sciences of the United States of America. 110: 10759-64. PMID 23754400 DOI: 10.1073/pnas.1308195110  0.88
2013 Allister EM, Robson-Doucette CA, Prentice KJ, Hardy AB, Sultan S, Gaisano HY, Kong D, Gilon P, Herrera PL, Lowell BB, Wheeler MB. UCP2 regulates the glucagon response to fasting and starvation. Diabetes. 62: 1623-33. PMID 23434936 DOI: 10.2337/db12-0981  0.88
2013 Sohn JW, Harris LE, Berglund ED, Liu T, Vong L, Lowell BB, Balthasar N, Williams KW, Elmquist JK. Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons. Cell. 152: 612-9. PMID 23374353 DOI: 10.1016/j.cell.2012.12.022  0.88
2013 Lou S, Duan B, Vong L, Lowell BB, Ma Q. Runx1 controls terminal morphology and mechanosensitivity of VGLUT3-expressing C-mechanoreceptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 870-82. PMID 23325226 DOI: 10.1523/JNEUROSCI.3942-12.2013  0.88
2012 Kong D, Tong Q, Ye C, Koda S, Fuller PM, Krashes MJ, Vong L, Ray RS, Olson DP, Lowell BB. GABAergic RIP-Cre neurons in the arcuate nucleus selectively regulate energy expenditure. Cell. 151: 645-57. PMID 23101631 DOI: 10.1016/j.cell.2012.09.020  0.88
2012 Wu Z, Xu Y, Zhu Y, Sutton AK, Zhao R, Lowell BB, Olson DP, Tong Q. An obligate role of oxytocin neurons in diet induced energy expenditure. Plos One. 7: e45167. PMID 23028821 DOI: 10.1371/journal.pone.0045167  0.88
2012 Huang H, Kong D, Byun KH, Ye C, Koda S, Lee DH, Oh BC, Lee SW, Lee B, Zabolotny JM, Kim MS, Bjørbæk C, Lowell BB, Kim YB. Rho-kinase regulates energy balance by targeting hypothalamic leptin receptor signaling. Nature Neuroscience. 15: 1391-8. PMID 22941110 DOI: 10.1038/nn.3207  0.88
2012 Kozorovitskiy Y, Saunders A, Johnson CA, Lowell BB, Sabatini BL. Recurrent network activity drives striatal synaptogenesis. Nature. 485: 646-50. PMID 22660328 DOI: 10.1038/nature11052  0.88
2012 Lee S, Bookout AL, Lee CE, Gautron L, Harper MJ, Elias CF, Lowell BB, Elmquist JK. Laser-capture microdissection and transcriptional profiling of the dorsomedial nucleus of the hypothalamus. The Journal of Comparative Neurology. 520: 3617-32. PMID 22473294 DOI: 10.1002/cne.23116  0.88
2012 Liu T, Kong D, Shah BP, Ye C, Koda S, Saunders A, Ding JB, Yang Z, Sabatini BL, Lowell BB. Fasting activation of AgRP neurons requires NMDA receptors and involves spinogenesis and increased excitatory tone. Neuron. 73: 511-22. PMID 22325203 DOI: 10.1016/j.neuron.2011.11.027  0.88
2012 Cohen JY, Haesler S, Vong L, Lowell BB, Uchida N. Neuron-type-specific signals for reward and punishment in the ventral tegmental area. Nature. 482: 85-8. PMID 22258508 DOI: 10.1038/nature10754  0.88
2012 Li C, Pleil KE, Stamatakis AM, Busan S, Vong L, Lowell BB, Stuber GD, Kash TL. Presynaptic inhibition of gamma-aminobutyric acid release in the bed nucleus of the stria terminalis by kappa opioid receptor signaling. Biological Psychiatry. 71: 725-32. PMID 22225848 DOI: 10.1016/j.biopsych.2011.11.015  0.88
2011 Krenzer M, Anaclet C, Vetrivelan R, Wang N, Vong L, Lowell BB, Fuller PM, Lu J. Brainstem and spinal cord circuitry regulating REM sleep and muscle atonia. Plos One. 6: e24998. PMID 22043278 DOI: 10.1371/journal.pone.0024998  0.88
2011 Vong L, Ye C, Yang Z, Choi B, Chua S, Lowell BB. Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. Neuron. 71: 142-54. PMID 21745644 DOI: 10.1016/j.neuron.2011.05.028  0.88
2011 Klöckener T, Hess S, Belgardt BF, Paeger L, Verhagen LA, Husch A, Sohn JW, Hampel B, Dhillon H, Zigman JM, Lowell BB, Williams KW, Elmquist JK, Horvath TL, Kloppenburg P, et al. High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons. Nature Neuroscience. 14: 911-8. PMID 21642975 DOI: 10.1038/nn.2847  0.88
2011 Higley MJ, Gittis AH, Oldenburg IA, Balthasar N, Seal RP, Edwards RH, Lowell BB, Kreitzer AC, Sabatini BL. Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum. Plos One. 6: e19155. PMID 21544206 DOI: 10.1371/journal.pone.0019155  0.88
2011 Mochizuki T, Arrigoni E, Marcus JN, Clark EL, Yamamoto M, Honer M, Borroni E, Lowell BB, Elmquist JK, Scammell TE. Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice. Proceedings of the National Academy of Sciences of the United States of America. 108: 4471-6. PMID 21368172 DOI: 10.1073/pnas.1012456108  0.88
2011 Krashes MJ, Koda S, Ye C, Rogan SC, Adams AC, Cusher DS, Maratos-Flier E, Roth BL, Lowell BB. Rapid, reversible activation of AgRP neurons drives feeding behavior in mice. The Journal of Clinical Investigation. 121: 1424-8. PMID 21364278 DOI: 10.1172/JCI46229  0.88
2011 Rossi J, Balthasar N, Olson D, Scott M, Berglund E, Lee CE, Choi MJ, Lauzon D, Lowell BB, Elmquist JK. Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis. Cell Metabolism. 13: 195-204. PMID 21284986 DOI: 10.1016/j.cmet.2011.01.010  0.88
2010 Xu Y, Jones JE, Lauzon DA, Anderson JG, Balthasar N, Heisler LK, Zinn AR, Lowell BB, Elmquist JK. A serotonin and melanocortin circuit mediates D-fenfluramine anorexia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 14630-4. PMID 21048120 DOI: 10.1523/JNEUROSCI.5412-09.2010  0.88
2010 Liu Y, Abdel Samad O, Zhang L, Duan B, Tong Q, Lopes C, Ji RR, Lowell BB, Ma Q. VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch. Neuron. 68: 543-56. PMID 21040853 DOI: 10.1016/j.neuron.2010.09.008  0.88
2010 Xu Y, Berglund ED, Sohn JW, Holland WL, Chuang JC, Fukuda M, Rossi J, Williams KW, Jones JE, Zigman JM, Lowell BB, Scherer PE, Elmquist JK. 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver. Nature Neuroscience. 13: 1457-9. PMID 21037584 DOI: 10.1038/nn.2664  0.88
2010 Kong D, Vong L, Parton LE, Ye C, Tong Q, Hu X, Choi B, Brüning JC, Lowell BB. Glucose stimulation of hypothalamic MCH neurons involves K(ATP) channels, is modulated by UCP2, and regulates peripheral glucose homeostasis. Cell Metabolism. 12: 545-52. PMID 21035764 DOI: 10.1016/j.cmet.2010.09.013  0.88
2010 Irani BG, Donato J, Olson DP, Lowell BB, Sacktor TC, Reyland ME, Tolson KP, Zinn AR, Ueta Y, Sakata I, Zigman JM, Elias CF, Clegg DJ. Distribution and neurochemical characterization of protein kinase C-theta and -delta in the rodent hypothalamus. Neuroscience. 170: 1065-79. PMID 20691763 DOI: 10.1016/j.neuroscience.2010.07.064  0.88
2010 Xu Y, Hill JW, Fukuda M, Gautron L, Sohn JW, Kim KW, Lee CE, Choi MJ, Lauzon DA, Dhillon H, Lowell BB, Zigman JM, Zhao JJ, Elmquist JK. PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis. Cell Metabolism. 12: 88-95. PMID 20620998 DOI: 10.1016/j.cmet.2010.05.002  0.88
2010 Hill JW, Elias CF, Fukuda M, Williams KW, Berglund ED, Holland WL, Cho YR, Chuang JC, Xu Y, Choi M, Lauzon D, Lee CE, Coppari R, Richardson JA, Zigman JM, ... ... Lowell BB, et al. Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. Cell Metabolism. 11: 286-97. PMID 20374961 DOI: 10.1016/j.cmet.2010.03.002  0.88
2010 Olson DP, Pulinilkunnil T, Cline GW, Shulman GI, Lowell BB. Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake Proceedings of the National Academy of Sciences of the United States of America. 107: 7598-7603. PMID 20368432 DOI: 10.1073/pnas.0913492107  0.88
2009 Hawke Z, Ivanov TR, Bechtold DA, Dhillon H, Lowell BB, Luckman SM. PACAP neurons in the hypothalamic ventromedial nucleus are targets of central leptin signaling. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 14828-35. PMID 19940178 DOI: 10.1523/JNEUROSCI.1526-09.2009  0.88
2009 Sakata I, Nakano Y, Osborne-Lawrence S, Rovinsky SA, Lee CE, Perello M, Anderson JG, Coppari R, Xiao G, Lowell BB, Elmquist JK, Zigman JM. Characterization of a novel ghrelin cell reporter mouse. Regulatory Peptides. 155: 91-8. PMID 19361544 DOI: 10.1016/j.regpep.2009.04.001  0.88
2009 van den Pol AN, Yao Y, Fu LY, Foo K, Huang H, Coppari R, Lowell BB, Broberger C. Neuromedin B and gastrin-releasing peptide excite arcuate nucleus neuropeptide Y neurons in a novel transgenic mouse expressing strong Renilla green fluorescent protein in NPY neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 4622-39. PMID 19357287 DOI: 10.1523/JNEUROSCI.3249-08.2009  0.88
2008 Tong Q, Ye CP, Jones JE, Elmquist JK, Lowell BB. Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance. Nature Neuroscience. 11: 998-1000. PMID 19160495 DOI: 10.1038/nn.2167  0.88
2008 Fukuda M, Jones JE, Olson D, Hill J, Lee CE, Gautron L, Choi M, Zigman JM, Lowell BB, Elmquist JK. Monitoring FoxO1 localization in chemically identified neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 13640-8. PMID 19074037 DOI: 10.1523/JNEUROSCI.4023-08.2008  0.88
2008 Xu Y, Jones JE, Kohno D, Williams KW, Lee CE, Choi MJ, Anderson JG, Heisler LK, Zigman JM, Lowell BB, Elmquist JK. 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis. Neuron. 60: 582-9. PMID 19038216 DOI: 10.1016/j.neuron.2008.09.033  0.88
2008 Zhang R, Dhillon H, Yin H, Yoshimura A, Lowell BB, Maratos-Flier E, Flier JS. Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight. Endocrinology. 149: 5654-61. PMID 18669597 DOI: 10.1210/en.2008-0805  0.88
2008 Hill JW, Williams KW, Ye C, Luo J, Balthasar N, Coppari R, Cowley MA, Cantley LC, Lowell BB, Elmquist JK. Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice. The Journal of Clinical Investigation. 118: 1796-805. PMID 18382766 DOI: 10.1172/JCI32964  0.88
2008 Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, ... ... Lowell BB, et al. Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nature Medicine. 14: 144-53. PMID 18223655 DOI: 10.1038/nm1717  0.88
2008 van de Wall E, Leshan R, Xu AW, Balthasar N, Coppari R, Liu SM, Jo YH, MacKenzie RG, Allison DB, Dun NJ, Elmquist J, Lowell BB, Barsh GS, de Luca C, Myers MG, et al. Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion. Endocrinology. 149: 1773-85. PMID 18162515 DOI: 10.1210/en.2007-1132  0.88
2007 Parton LE, Ye CP, Coppari R, Enriori PJ, Choi B, Zhang CY, Xu C, Vianna CR, Balthasar N, Lee CE, Elmquist JK, Cowley MA, Lowell BB. Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature. 449: 228-32. PMID 17728716 DOI: 10.1038/nature06098  0.88
2007 Lazarus M, Yoshida K, Coppari R, Bass CE, Mochizuki T, Lowell BB, Saper CB. EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses. Nature Neuroscience. 10: 1131-3. PMID 17676060 DOI: 10.1038/nn1949  0.88
2007 McHugh TJ, Jones MW, Quinn JJ, Balthasar N, Coppari R, Elmquist JK, Lowell BB, Fanselow MS, Wilson MA, Tonegawa S. Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network. Science (New York, N.Y.). 317: 94-9. PMID 17556551 DOI: 10.1126/science.1140263  0.88
2007 Tong Q, Ye C, McCrimmon RJ, Dhillon H, Choi B, Kramer MD, Yu J, Yang Z, Christiansen LM, Lee CE, Choi CS, Zigman JM, Shulman GI, Sherwin RS, Elmquist JK, ... Lowell BB, et al. Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia. Cell Metabolism. 5: 383-93. PMID 17488640 DOI: 10.1016/j.cmet.2007.04.001  0.88
2006 Vianna CR, Huntgeburth M, Coppari R, Choi CS, Lin J, Krauss S, Barbatelli G, Tzameli I, Kim YB, Cinti S, Shulman GI, Spiegelman BM, Lowell BB. Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance. Cell Metabolism. 4: 453-64. PMID 17141629 DOI: 10.1016/j.cmet.2006.11.003  0.88
2006 Heisler LK, Jobst EE, Sutton GM, Zhou L, Borok E, Thornton-Jones Z, Liu HY, Zigman JM, Balthasar N, Kishi T, Lee CE, Aschkenasi CJ, Zhang CY, Yu J, Boss O, ... ... Lowell BB, et al. Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron. 51: 239-49. PMID 16846858 DOI: 10.1016/j.neuron.2006.06.004  0.88
2006 Zhang CY, Parton LE, Ye CP, Krauss S, Shen R, Lin CT, Porco JA, Lowell BB. Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets. Cell Metabolism. 3: 417-27. PMID 16753577 DOI: 10.1016/j.cmet.2006.04.010  0.88
2006 Dhillon H, Zigman JM, Ye C, Lee CE, McGovern RA, Tang V, Kenny CD, Christiansen LM, White RD, Edelstein EA, Coppari R, Balthasar N, Cowley MA, Chua S, Elmquist JK, ... Lowell BB, et al. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron. 49: 191-203. PMID 16423694 DOI: 10.1016/j.neuron.2005.12.021  0.88
2005 Zigman JM, Nakano Y, Coppari R, Balthasar N, Marcus JN, Lee CE, Jones JE, Deysher AE, Waxman AR, White RD, Williams TD, Lachey JL, Seeley RJ, Lowell BB, Elmquist JK. Mice lacking ghrelin receptors resist the development of diet-induced obesity. The Journal of Clinical Investigation. 115: 3564-72. PMID 16322794 DOI: 10.1172/JCI26002  0.88
2005 Balthasar N, Dalgaard LT, Lee CE, Yu J, Funahashi H, Williams T, Ferreira M, Tang V, McGovern RA, Kenny CD, Christiansen LM, Edelstein E, Choi B, Boss O, Aschkenasi C, ... ... Lowell BB, et al. Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell. 123: 493-505. PMID 16269339 DOI: 10.1016/j.cell.2005.08.035  0.88
2005 Elmquist JK, Coppari R, Balthasar N, Ichinose M, Lowell BB. Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis. The Journal of Comparative Neurology. 493: 63-71. PMID 16254991 DOI: 10.1002/cne.20786  0.88
2005 Coppari R, Ichinose M, Lee CE, Pullen AE, Kenny CD, McGovern RA, Tang V, Liu SM, Ludwig T, Chua SC, Lowell BB, Elmquist JK. The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity. Cell Metabolism. 1: 63-72. PMID 16054045 DOI: 10.1016/j.cmet.2004.12.004  0.88
2005 Krauss S, Zhang CY, Lowell BB. The mitochondrial uncoupling-protein homologues. Nature Reviews. Molecular Cell Biology. 6: 248-61. PMID 15738989 DOI: 10.1038/nrm1572  0.88
2005 Lowell BB, Shulman GI. Mitochondrial dysfunction and type 2 diabetes. Science (New York, N.Y.). 307: 384-7. PMID 15662004 DOI: 10.1126/science.1104343  0.88
2005 Solanes G, Pedraza N, Calvo V, Vidal-Puig A, Lowell BB, Villarroya F. Thyroid hormones directly activate the expression of the human and mouse uncoupling protein-3 genes through a thyroid response element in the proximal promoter region. The Biochemical Journal. 386: 505-13. PMID 15496137 DOI: 10.1042/BJ20041073  0.88
2004 Lin J, Wu PH, Tarr PT, Lindenberg KS, St-Pierre J, Zhang CY, Mootha VK, Jäger S, Vianna CR, Reznick RM, Cui L, Manieri M, Donovan MX, Wu Z, Cooper MP, ... ... Lowell BB, et al. Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell. 119: 121-35. PMID 15454086 DOI: 10.1016/j.cell.2004.09.013  0.88
2004 Joseph JW, Koshkin V, Saleh MC, Sivitz WI, Zhang CY, Lowell BB, Chan CB, Wheeler MB. Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression. The Journal of Biological Chemistry. 279: 51049-56. PMID 15448158 DOI: 10.1074/jbc.M409189200  0.88
2004 Balthasar N, Coppari R, McMinn J, Liu SM, Lee CE, Tang V, Kenny CD, McGovern RA, Chua SC, Elmquist JK, Lowell BB. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron. 42: 983-91. PMID 15207242 DOI: 10.1016/j.neuron.2004.06.004  0.88
2003 Krauss S, Zhang CY, Scorrano L, Dalgaard LT, St-Pierre J, Grey ST, Lowell BB. Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction. The Journal of Clinical Investigation. 112: 1831-42. PMID 14679178 DOI: 10.1172/JCI19774  0.88
2003 Danial NN, Gramm CF, Scorrano L, Zhang CY, Krauss S, Ranger AM, Datta SR, Greenberg ME, Licklider LJ, Lowell BB, Gygi SP, Korsmeyer SJ. BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature. 424: 952-6. PMID 12931191 DOI: 10.1038/nature01825  0.88
2003 Nakayama A, Bianco AC, Zhang CY, Lowell BB, Frangioni JV. Quantitation of brown adipose tissue perfusion in transgenic mice using near-infrared fluorescence imaging. Molecular Imaging. 2: 37-49. PMID 12926236 DOI: 10.1162/153535003765276273  0.88
2003 Yoon JC, Xu G, Deeney JT, Yang SN, Rhee J, Puigserver P, Levens AR, Yang R, Zhang CY, Lowell BB, Berggren PO, Newgard CB, Bonner-Weir S, Weir G, Spiegelman BM. Suppression of beta cell energy metabolism and insulin release by PGC-1alpha. Developmental Cell. 5: 73-83. PMID 12852853 DOI: 10.1016/S1534-5807(03)00170-9  0.88
2003 Lowell BB, Bachman ES. Beta-Adrenergic receptors, diet-induced thermogenesis, and obesity. The Journal of Biological Chemistry. 278: 29385-8. PMID 12788929 DOI: 10.1074/jbc.R300011200  0.88
2002 Joseph JW, Koshkin V, Zhang CY, Wang J, Lowell BB, Chan CB, Wheeler MB. Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet. Diabetes. 51: 3211-9. PMID 12401712  0.88
2002 Boucher J, Castan-Laurell I, Le Lay S, Grujic D, Sibrac D, Krief S, Lafontan M, Lowell BB, Dugail I, Saulnier-Blache JS, Valet P. Human alpha 2A-adrenergic receptor gene expressed in transgenic mouse adipose tissue under the control of its regulatory elements. Journal of Molecular Endocrinology. 29: 251-64. PMID 12370125 DOI: 10.1677/jme.0.0290251  0.88
2002 Lin J, Wu H, Tarr PT, Zhang CY, Wu Z, Boss O, Michael LF, Puigserver P, Isotani E, Olson EN, Lowell BB, Bassel-Duby R, Spiegelman BM. Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature. 418: 797-801. PMID 12181572 DOI: 10.1038/nature00904  0.88
2002 Bachman ES, Dhillon H, Zhang CY, Cinti S, Bianco AC, Kobilka BK, Lowell BB. betaAR signaling required for diet-induced thermogenesis and obesity resistance. Science (New York, N.Y.). 297: 843-5. PMID 12161655 DOI: 10.1126/science.1073160  0.88
2002 Rupnick MA, Panigrahy D, Zhang CY, Dallabrida SM, Lowell BB, Langer R, Folkman MJ. Adipose tissue mass can be regulated through the vasculature. Proceedings of the National Academy of Sciences of the United States of America. 99: 10730-5. PMID 12149466 DOI: 10.1073/pnas.162349799  0.88
2002 Jost P, Fasshauer M, Kahn CR, Benito M, Meyer M, Ott V, Lowell BB, Klein HH, Klein J. Atypical beta-adrenergic effects on insulin signaling and action in beta(3)-adrenoceptor-deficient brown adipocytes. American Journal of Physiology. Endocrinology and Metabolism. 283: E146-53. PMID 12067855 DOI: 10.1152/ajpendo.00531.2001  0.88
2002 Baffy G, Zhang CY, Glickman JN, Lowell BB. Obesity-related fatty liver is unchanged in mice deficient for mitochondrial uncoupling protein 2. Hepatology (Baltimore, Md.). 35: 753-61. PMID 11915020 DOI: 10.1053/jhep.2002.32028  0.88
2002 Krauss S, Zhang CY, Lowell BB. A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2. Proceedings of the National Academy of Sciences of the United States of America. 99: 118-22. PMID 11756659 DOI: 10.1073/pnas.012410699  0.88
2001 Puigserver P, Rhee J, Lin J, Wu Z, Yoon JC, Zhang CY, Krauss S, Mootha VK, Lowell BB, Spiegelman BM. Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1. Molecular Cell. 8: 971-82. PMID 11741533 DOI: 10.1016/S1097-2765(01)00390-2  0.88
2001 Dumont LM, Wu CS, Aschkenasi CJ, Elmquist JK, Lowell BB, Mountjoy KG. Mouse melanocortin-4 receptor gene 5'-flanking region imparts cell specific expression in vitro. Molecular and Cellular Endocrinology. 184: 173-85. PMID 11694353 DOI: 10.1016/S0303-7207(01)00558-5  0.88
2001 Zhang CY, Baffy G, Perret P, Krauss S, Peroni O, Grujic D, Hagen T, Vidal-Puig AJ, Boss O, Kim YB, Zheng XX, Wheeler MB, Shulman GI, Chan CB, Lowell BB. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β cell dysfunction, and type 2 diabetes Cell. 105: 745-755. PMID 11440717 DOI: 10.1016/S0092-8674(01)00378-6  0.88
2001 Huppertz C, Fischer BM, Kim YB, Kotani K, Vidal-Puig A, Slieker LJ, Sloop KW, Lowell BB, Kahn BB. Uncoupling Protein 3 (UCP3) Stimulates Glucose Uptake in Muscle Cells through a Phosphoinositide 3-Kinase-dependent Mechanism Journal of Biological Chemistry. 276: 12520-12529. PMID 11278970 DOI: 10.1074/jbc.M011708200  0.88
2001 Cline GW, Vidal-Puig AJ, Dufour S, Cadman KS, Lowell BB, Shulman GI. In Vivo Effects of Uncoupling Protein-3 Gene Disruption on Mitochondrial Energy Metabolism Journal of Biological Chemistry. 276: 20240-20244. PMID 11274222 DOI: 10.1074/jbc.M102540200  0.88
2001 Ludwig DS, Tritos NA, Mastaitis JW, Kulkarni R, Kokkotou E, Elmquist J, Lowell B, Flier JS, Maratos-Flier E. Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance. The Journal of Clinical Investigation. 107: 379-86. PMID 11160162 DOI: 10.1172/JCI10660  0.88
2001 Vianna CR, Hagen T, Zhang CY, Bachman E, Boss O, Gereben B, Moriscot AS, Lowell BB, Bicudo JEPW, Bianco AC. Cloning and functional characterization of an uncoupling protein homolog in hummingbirds Physiological Genomics. 2001: 137-145.  0.88
2000 Ristow M, Pfister MF, Yee AJ, Schubert M, Michael L, Zhang CY, Ueki K, Michael MD, Lowell BB, Kahn CR. Frataxin activates mitochondrial energy conversion and oxidative phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 97: 12239-43. PMID 11035806 DOI: 10.1073/pnas.220403797  0.88
2000 Hagen T, Lowell BB. Chimeric proteins between UCP1 and UCP3: The middle third of UCP1 is necessary and sufficient for activation by fatty acids Biochemical and Biophysical Research Communications. 276: 642-648. PMID 11027525 DOI: 10.1006/bbrc.2000.3535  0.88
2000 Valet P, Grujic D, Wade J, Ito M, Zingaretti MC, Soloveva V, Ross SR, Graves RA, Cinti S, Lafontan M, Lowell BB. Expression of human alpha 2-adrenergic receptors in adipose tissue of beta 3-adrenergic receptor-deficient mice promotes diet-induced obesity. The Journal of Biological Chemistry. 275: 34797-802. PMID 10948198 DOI: 10.1074/jbc.M005210200  0.88
2000 Zisman A, Peroni OD, Abel ED, Michael MD, Mauvais-Jarvis F, Lowell BB, Wojtaszewski JFP, Hirshman MF, Virkamaki A, Goodyear LJ, Kahn CR, Kahn BB. Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance Nature Medicine. 6: 924-928. PMID 10932232 DOI: 10.1038/78693  0.88
2000 Boss O, Hagen T, Lowell BB. Uncoupling proteins 2 and 3: Potential regulators of mitochondrial energy metabolism Diabetes. 49: 143-156. PMID 10868929  0.88
2000 Hagen T, Zhang CY, Vianna CR, Lowell BB. Uncoupling proteins 1 and 3 are regulated differently Biochemistry. 39: 5845-5851. PMID 10801335 DOI: 10.1021/bi992980+  0.88
2000 Cohen ML, Bloomquist W, Ito M, Lowell BB. Beta3 receptors mediate relaxation in stomach fundus whereas a fourth beta receptor mediates tachycardia in atria from transgenic beta3 receptor knockout mice. Receptors & Channels. 7: 17-23. PMID 10800773  0.88
2000 Lowell BB, Spiegelman BM. Towards a molecular understanding of adaptive thermogenesis Nature. 404: 652-660. PMID 10766252  0.88
2000 Vidal-Puig AJ, Grujic D, Zhang CY, Hagen T, Boss O, Ido Y, Szczepanik A, Wade J, Mootha V, Cortright R, Muoio DM, Lowell BB. Energy metabolism in uncoupling protein 3 gene knockout mice Journal of Biological Chemistry. 275: 16258-16266. PMID 10748196 DOI: 10.1074/jbc.M910179199  0.88
1999 Abel ED, Kaulbach HC, Tian R, Hopkins JC, Duffy J, Doetschman T, Minnemann T, Boers ME, Hadro E, Oberste-Berghaus C, Quist W, Lowell BB, Ingwall JS, Kahn BB. Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart. The Journal of Clinical Investigation. 104: 1703-14. PMID 10606624 DOI: 10.1172/JCI7605  0.88
1999 Klein J, Fasshauer M, Ito M, Lowell BB, Benito M, Kahn CR. β3-Adrenergic stimulation differentially inhibits insulin signaling and decreases insulin-induced glucose uptake in brown adipocytes Journal of Biological Chemistry. 274: 34795-34802. PMID 10574950 DOI: 10.1074/jbc.274.49.34795  0.88
1999 Lowell BB. PPARγ: An essential regulator of adipogenesis and modulator of fat cell function Cell. 99: 239-242. PMID 10555139 DOI: 10.1016/S0092-8674(00)81654-2  0.88
1999 Chung WK, Luke A, Cooper RS, Rotini C, Vidal-Puig A, Rosenbaum M, Chua M, Solanes G, Zheng M, Zhao L, LeDuc C, Eisberg A, Chu F, Murphy E, Schreier M, ... ... Lowell BB, et al. Genetic and physiologic analysis of the role of uncoupling protein 3 in human energy homeostasis Diabetes. 48: 1890-1895. PMID 10480626 DOI: 10.2337/diabetes.48.9.1890  0.88
1999 Chung WK, Luke A, Cooper RS, Rotini C, Vidal-Puig A, Rosenbaum M, Gordon D, Leal SM, Caprio S, Goldsmith R, Andreu AL, Bruno C, DiMauro S, Heo M, Lowe WL, ... Lowell BB, et al. The long isoform uncoupling protein-3 (UCP3L) in human energy homeostasis. International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association For the Study of Obesity. 23: S49-50. PMID 10454123  0.88
1999 Lowell BB. Uncoupling protein-3 (UCP3): A mitochondrial carrier in search of a function International Journal of Obesity. 23: S43-S45. PMID 10454121  0.88
1999 Boss O, Bachman E, Vidal-Puig A, Zhang CY, Peroni O, Lowell BB. Role of the β3-adrenergic receptor and/or a putative β4-adrenergic receptor on the expression of uncoupling proteins and peroxisome proliferator-activated receptor-γ coactivator-1 Biochemical and Biophysical Research Communications. 261: 870-876. PMID 10441518 DOI: 10.1006/bbrc.1999.1145  0.88
1999 Hagen T, Zhang CY, Slieker LJ, Chung WK, Leibel RL, Lowell BB. Assessment of uncoupling activity of the human uncoupling protein 3 short form and three mutants of the uncoupling protein gene using a yeast heterologous expression system Febs Letters. 454: 201-206. PMID 10431807 DOI: 10.1016/S0014-5793(99)00811-X  0.88
1999 Abel ED, Boers ME, Pazos-Moura C, Moura E, Kaulbach H, Zakaria M, Lowell B, Radovick S, Liberman MC, Wondisford F. Divergent roles for thyroid hormone receptor beta isoforms in the endocrine axis and auditory system. The Journal of Clinical Investigation. 104: 291-300. PMID 10430610 DOI: 10.1172/JCI6397  0.88
1999 Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, Spiegelman BM. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell. 98: 115-24. PMID 10412986 DOI: 10.1016/S0092-8674(00)80611-X  0.88
1999 Zhang CY, Hagen T, Mootha VK, Slieker LJ, Lowell BB. Assessment of uncoupling activity of uncoupling protein 3 using a yeast heterologous expression system Febs Letters. 449: 129-134. PMID 10338118 DOI: 10.1016/S0014-5793(99)00441-X  0.88
1999 Vidal-Puig A, Rosenbaum M, Considine RC, Leibel RL, Dohm GL, Lowell BB. Effects of obesity and stable weight reduction on UCP2 and UCP3 gene expression in humans Obesity Research. 7: 133-140. PMID 10102249  0.88
1999 Cortright RN, Zheng D, Jones JP, Fluckey JD, DiCarlo SE, Grujic D, Lowell BB, Dohm GL. Regulation of skeletal muscle UCP-2 and UCP-3 gene expression by exercise and denervation. The American Journal of Physiology. 276: E217-21. PMID 9886970  0.88
1998 Shimada M, Tritos NA, Lowell BB, Flier JS, Maratos-Flier E. Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature. 396: 670-4. PMID 9872314 DOI: 10.1038/25341  0.88
1998 Fletcher DS, Candelore MR, Grujic D, Lowell BB, Luell S, Susulic VS, Macintyre DE. Beta-3 adrenergic receptor agonists cause an increase in gastrointestinal transit time in wild-type mice, but not in mice lacking the Beta-3 adrenergic receptor Journal of Pharmacology and Experimental Therapeutics. 287: 720-724. PMID 9808702  0.88
1998 Lowell BB. Using gene knockout and transgenic techniques to study the physiology and pharmacology of β3-adrenergic receptors Endocrine Journal. 45: S9-S13. PMID 9790223  0.88
1998 Boyer BB, Barnes BM, Lowell BB, Grujic D. Differential regulation of uncoupling protein gene homologues in multiple tissues of hibernating ground squirrels. The American Journal of Physiology. 275: R1232-8. PMID 9756555  0.88
1998 Ito M, Grujic D, Dale Abel E, Vidal-Puig A, Susulic VS, Lawitts J, Harper ME, Himins-Hagen J, Donny Strosberg A, Lowell BB. Mice expressing human but not murine β3-adrenergic receptors under the control of human gene regulatory elements Diabetes. 47: 1464-1471. PMID 9726236  0.88
1998 Lowell BB. Adaptive thermogenesis: Turning on the heat Current Biology. 8: R517-R520. PMID 9705924  0.88
1998 Walder K, Norman RA, Hanson RL, Schrauwen P, Neverova M, Jenkinson CP, Easlick J, Warden CH, Pecqueur C, Raimbault S, Ricquier D, Harper M, Silver K, Shuldiner AR, Solanes G, ... Lowell BB, et al. Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima Indians Human Molecular Genetics. 7: 1431-1435. PMID 9700198 DOI: 10.1093/hmg/7.9.1431  0.88
1998 Hamann A, Flier JS, Lowell BB. Obesity after genetic ablation of brown adipose tissue Zeitschrift Fur Ernahrungswissenschaft. 37: 1-7. PMID 9558722  0.88
1998 Mantzoros CS, Frederich RC, Qu D, Lowell BB, Maratos-Flier E, Flier JS. Severe leptin resistance in brown fat-deficient uncoupling protein promoter-driven diphtheria toxin A mice despite suppression of hypothalamic neuropeptide Y and circulating corticosterone concentrations Diabetes. 47: 230-238. PMID 9519718  0.88
1998 Kim JB, Sarraf P, Wright M, Yao KM, Mueller E, Solanes G, Lowell BB, Spiegelman BM. Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1 Journal of Clinical Investigation. 101: 1-9. PMID 9421459  0.88
1997 Solanes G, Vidal-Puig A, Grujic D, Flier JS, Lowell BB. The human uncoupling protein-3 gene. Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts Journal of Biological Chemistry. 272: 25433-25436. PMID 9325252 DOI: 10.1074/jbc.272.41.25433  0.88
1997 Vidal-Puig A, Solanes G, Grujic D, Flier JS, Lowell BB. UCP3: An uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue Biochemical and Biophysical Research Communications. 235: 79-82. PMID 9196039 DOI: 10.1006/bbrc.1997.6740  0.88
1997 Flier JS, Lowell BB. Obesity research springs a proton leak Nature Genetics. 15: 223-224. PMID 9054925 DOI: 10.1038/ng0397-223  0.88
1997 Lowell BB, Flier JS. Brown adipose tissue, β3-adrenergic receptors, and obesity Annual Review of Medicine. 48: 307-316. PMID 9046964 DOI: 10.1146/annurev.med.48.1.307  0.88
1997 Hollenberg AN, Susulic VS, Madura JP, Zhang B, Moller DE, Tontonoz P, Sarraf P, Spiegelman BM, Lowell BB. Functional antagonism between CCAAT/enhancer binding protein-α and peroxisome proliferator-activated receptor-γ on the leptin promoter Journal of Biological Chemistry. 272: 5283-5290. PMID 9030601 DOI: 10.1074/jbc.272.8.5283  0.88
1997 Cinti S, Frederich RC, Zingaretti MC, De Matteis R, Flier JS, Lowell BB. Immunohistochemical localization of leptin and uncoupling protein in white and brown adipose tissue Endocrinology. 138: 797-804. PMID 9003017 DOI: 10.1210/en.138.2.797  0.88
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