Miguel A. Pappolla, MD PhD - Publications

Affiliations: 
2008- Neurology University of Texas Medical Branch, Galveston, TX 
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http://www.biomedexperts.com/Start/PersonDetailPage.aspx?pid=1902032
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http://www.facebook.com/people/Miguel-Pappolla-Md-Houston/100000687766246

64 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Pappolla MA, Perry G, Fang X, Zagorski M, Sambamurti K, Poeggeler B. Indoles as essential mediators in the gut-brain axis. Their role in Alzheimer's disease. Neurobiology of Disease. 105403. PMID 34087380 DOI: 10.1016/j.nbd.2021.105403  0.67
2018 Pappolla MA, Matsubara E, Vidal R, Pacheco-Quinto J, Poeggeler B, Zagorski M, Sambamurti K. Melatonin treatment enhances Aβ lymphatic clearance in a transgenic mouse model of amyloidosis. Current Alzheimer Research. PMID 29637859 DOI: 10.2174/1567205015666180411092551  0.674
2015 Baranello RJ, Bharani KL, Padmaraju V, Chopra N, Lahiri DK, Greig NH, Pappolla MA, Sambamurti K. Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease. Current Alzheimer Research. 12: 32-46. PMID 25523424 DOI: 10.2174/1567205012666141218140953  0.694
2014 Pappolla M, Sambamurti K, Vidal R, Pacheco-Quinto J, Poeggeler B, Matsubara E. Evidence for lymphatic Aβ clearance in Alzheimer's transgenic mice. Neurobiology of Disease. 71: 215-9. PMID 25102344 DOI: 10.1016/J.Nbd.2014.07.012  0.64
2014 Barnwell E, Padmaraju V, Baranello R, Pacheco-Quinto J, Crosson C, Ablonczy Z, Eckman E, Eckman CB, Ramakrishnan V, Greig NH, Pappolla MA, Sambamurti K. Evidence of a novel mechanism for partial γ-secretase inhibition induced paradoxical increase in secreted amyloid β protein. Plos One. 9: e91531. PMID 24658363 DOI: 10.1371/Journal.Pone.0091531  0.636
2014 Pappolla M, Sambamurti K, Vidal R, Pacheco-Quinto J, Poeggeler B, Matsubara E. Evidence for lymphatic Aβ clearance in Alzheimer's transgenic mice Neurobiology of Disease. 71: 215-219. DOI: 10.1016/j.nbd.2014.07.012  0.612
2013 Pinnix I, Ghiso JA, Pappolla MA, Sambamurti K. Major carboxyl terminal fragments generated by γ-secretase processing of the Alzheimer amyloid precursor are 50 and 51 amino acids long. The American Journal of Geriatric Psychiatry : Official Journal of the American Association For Geriatric Psychiatry. 21: 474-83. PMID 23570890 DOI: 10.1016/J.Jagp.2013.02.009  0.643
2011 Sambamurti K, Greig NH, Utsuki T, Barnwell EL, Sharma E, Mazell C, Bhat NR, Kindy MS, Lahiri DK, Pappolla MA. Targets for AD treatment: conflicting messages from γ-secretase inhibitors. Journal of Neurochemistry. 117: 359-74. PMID 21320126 DOI: 10.1111/J.1471-4159.2011.07213.X  0.682
2010 Poeggeler B, Sambamurti K, Siedlak SL, Perry G, Smith MA, Pappolla MA. A novel endogenous indole protects rodent mitochondria and extends rotifer lifespan. Plos One. 5: e10206. PMID 20421998 DOI: 10.1371/Journal.Pone.0010206  0.691
2010 Prakasam A, Muthuswamy A, Ablonczy Z, Greig NH, Fauq A, Rao KJ, Pappolla MA, Sambamurti K. Differential accumulation of secreted AbetaPP metabolites in ocular fluids. Journal of Alzheimer's Disease : Jad. 20: 1243-53. PMID 20413851 DOI: 10.3233/Jad-2010-100210  0.669
2010 Zambón D, Quintana M, Mata P, Alonso R, Benavent J, Cruz-Sánchez F, Gich J, Pocoví M, Civeira F, Capurro S, Bachman D, Sambamurti K, Nicholas J, Pappolla MA. Higher incidence of mild cognitive impairment in familial hypercholesterolemia. The American Journal of Medicine. 123: 267-74. PMID 20193836 DOI: 10.1016/J.Amjmed.2009.08.015  0.565
2009 Sambamurti K, Jagannatha Rao KS, Pappolla MA. Frontiers in the pathogenesis of Alzheimer's disease. Indian Journal of Psychiatry. 51: S56-60. PMID 21416019  0.639
2009 Siedlak SL, Casadesus G, Webber KM, Pappolla MA, Atwood CS, Smith MA, Perry G. Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease. Free Radical Research. 43: 156-64. PMID 19160110 DOI: 10.1080/10715760802644694  0.738
2008 Venugopal C, Demos CM, Rao KS, Pappolla MA, Sambamurti K. Beta-secretase: structure, function, and evolution. Cns & Neurological Disorders Drug Targets. 7: 278-94. PMID 18673212 DOI: 10.2174/187152708784936626  0.676
2008 Sambamurti K, Pappolla MA, Jagannatha Rao KS. Value in development of a TAPIR-like mouse monoclonal antibody to Abeta. Journal of Alzheimer's Disease : Jad. 14: 175-7. PMID 18663823 DOI: 10.3233/Jad-2008-14205  0.691
2008 Sambamurti K, Prakasam A, Jayachandran AD, Venugopal C, Rao JK, Lahiri DK, Greig NH, Pappolla MA, Zhou Y. P1-412: Isoprenoids phenocopy familial Alzheimer's disease mutations and regulate gamma-secretase Alzheimer's & Dementia. 4: T340-T340. DOI: 10.1016/J.Jalz.2008.05.994  0.61
2008 Pappolla MA, Ros E, Sambamurti K, Pocovi M, Nicholas J, Mata P, Alonso R, Bachman D, Cruz-Sanchez F, Benavent J, Capurro S, Zambon D. O1-01-08: Cognitive impairment in heterozygous familial hypercholesterolemia Alzheimer's & Dementia. 4: T108-T108. DOI: 10.1016/J.Jalz.2008.05.218  0.54
2008 Pacheco-Quinto J, Sambamurti K, Pappolla MA. P3-343: Homocysteine inhibits the enzymatic degradation of Aβ peptide Alzheimer's & Dementia. 4: T622-T622. DOI: 10.1016/J.Jalz.2008.05.1912  0.607
2007 Venugopal C, Pappolla MA, Sambamurti K. Insulysin cleaves the APP cytoplasmic fragment at multiple sites. Neurochemical Research. 32: 2225-34. PMID 17701350 DOI: 10.1007/S11064-007-9449-Z  0.671
2006 Pacheco-Quinto J, Rodriguez de Turco EB, DeRosa S, Howard A, Cruz-Sanchez F, Sambamurti K, Refolo L, Petanceska S, Pappolla MA. Hyperhomocysteinemic Alzheimer's mouse model of amyloidosis shows increased brain amyloid beta peptide levels. Neurobiology of Disease. 22: 651-6. PMID 16516482 DOI: 10.1016/J.Nbd.2006.01.005  0.687
2006 Casadesus G, Webber KM, Atwood CS, Pappolla MA, Perry G, Bowen RL, Smith MA. Luteinizing hormone modulates cognition and amyloid-beta deposition in Alzheimer APP transgenic mice. Biochimica Et Biophysica Acta. 1762: 447-52. PMID 16503402 DOI: 10.1016/J.Bbadis.2006.01.008  0.743
2005 Poeggeler B, Durand G, Polidori A, Pappolla MA, Vega-Naredo I, Coto-Montes A, Böker J, Hardeland R, Pucci B. Mitochondrial medicine: neuroprotection and life extension by the new amphiphilic nitrone LPBNAH acting as a highly potent antioxidant agent. Journal of Neurochemistry. 95: 962-73. PMID 16135084 DOI: 10.1111/j.1471-4159.2005.03425.x  0.37
2005 Lukiw WJ, Pappolla M, Pelaez RP, Bazan NG. Alzheimer's disease--a dysfunction in cholesterol and lipid metabolism. Cellular and Molecular Neurobiology. 25: 475-83. PMID 16075376 DOI: 10.1007/S10571-005-4010-6  0.382
2003 Marlow L, Cain M, Pappolla MA, Sambamurti K. Beta-secretase processing of the Alzheimer's amyloid protein precursor (APP). Journal of Molecular Neuroscience : Mn. 20: 233-9. PMID 14501002 DOI: 10.1385/Jmn:20:3:233  0.674
2003 Wadghiri YZ, Sigurdsson EM, Sadowski M, Elliott JI, Li Y, Scholtzova H, Tang CY, Aguinaldo G, Pappolla M, Duff K, Wisniewski T, Turnbull DH. Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging. Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 50: 293-302. PMID 12876705 DOI: 10.1002/Mrm.10529  0.456
2003 Pappolla MA, Bryant-Thomas TK, Herbert D, Pacheco J, Fabra Garcia M, Manjon M, Girones X, Henry TL, Matsubara E, Zambon D, Wolozin B, Sano M, Cruz-Sanchez FF, Thal LJ, Petanceska SS, et al. Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology. Neurology. 61: 199-205. PMID 12874399 DOI: 10.1212/01.Wnl.0000070182.02537.84  0.459
2003 Matsubara E, Bryant-Thomas T, Pacheco Quinto J, Henry TL, Poeggeler B, Herbert D, Cruz-Sanchez F, Chyan YJ, Smith MA, Perry G, Shoji M, Abe K, Leone A, Grundke-Ikbal I, Wilson GL, ... ... Pappolla MA, et al. Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease. Journal of Neurochemistry. 85: 1101-8. PMID 12753069 DOI: 10.1046/J.1471-4159.2003.01654.X  0.706
2002 Bozner P, Wilson GL, Druzhyna NM, Bryant-Thomas TK, LeDoux SP, Wilson GL, Pappolla MA. Deficiency of chaperonin 60 in Down's syndrome. Journal of Alzheimer's Disease : Jad. 4: 479-86. PMID 12515899 DOI: 10.3233/Jad-2002-4604  0.374
2002 Pappolla MA, Smith MA, Bryant-Thomas T, Bazan N, Petanceska S, Perry G, Thal LJ, Sano M, Refolo LM. Cholesterol, oxidative stress, and Alzheimer's disease: expanding the horizons of pathogenesis. Free Radical Biology & Medicine. 33: 173-81. PMID 12106813 DOI: 10.1016/S0891-5849(02)00841-9  0.681
2002 Pappolla MA, Simovich MJ, Bryant-Thomas T, Chyan YJ, Poeggeler B, Dubocovich M, Bick R, Perry G, Cruz-Sanchez F, Smith MA. The neuroprotective activities of melatonin against the Alzheimer beta-protein are not mediated by melatonin membrane receptors. Journal of Pineal Research. 32: 135-42. PMID 12074096 DOI: 10.1034/J.1600-079X.2002.1O838.X  0.662
2001 Poeggeler B, Miravalle L, Zagorski MG, Wisniewski T, Chyan YJ, Zhang Y, Shao H, Bryant-Thomas T, Vidal R, Frangione B, Ghiso J, Pappolla MA. Melatonin reverses the profibrillogenic activity of apolipoprotein E4 on the Alzheimer amyloid Abeta peptide. Biochemistry. 40: 14995-5001. PMID 11732920 DOI: 10.1021/Bi0114269  0.641
2001 Pappolla MA, Omar RA, Chyan YJ, Ghiso J, Hsiao K, Bozner P, Perry G, Smith MA, Cruz-Sanchez F. Induction of NADPH cytochrome P450 reductase by the Alzheimer beta-protein. Amyloid as a "foreign body". Journal of Neurochemistry. 78: 121-8. PMID 11432979 DOI: 10.1046/J.1471-4159.2001.00379.X  0.697
2000 Nunomura A, Perry G, Pappolla MA, Friedland RP, Hirai K, Chiba S, Smith MA. Neuronal oxidative stress precedes amyloid-beta deposition in Down syndrome. Journal of Neuropathology and Experimental Neurology. 59: 1011-7. PMID 11089579 DOI: 10.1093/Jnen/59.11.1011  0.771
2000 Refolo LM, Malester B, LaFrancois J, Bryant-Thomas T, Wang R, Tint GS, Sambamurti K, Duff K, Pappolla MA. Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model. Neurobiology of Disease. 7: 321-31. PMID 10964604 DOI: 10.1006/Nbdi.2000.0304  0.682
2000 Pappolla MA, Chyan YJ, Poeggeler B, Frangione B, Wilson G, Ghiso J, Reiter RJ. An assessment of the antioxidant and the antiamyloidogenic properties of melatonin: implications for Alzheimer's disease. Journal of Neural Transmission (Vienna, Austria : 1996). 107: 203-31. PMID 10847561 DOI: 10.1007/S007020050018  0.595
1999 Omar RA, Chyan YJ, Andorn AC, Poeggeler B, Robakis NK, Pappolla MA. Increased Expression but Reduced Activity of Antioxidant Enzymes in Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. 1: 139-145. PMID 12213999 DOI: 10.3233/Jad-1999-1301  0.537
1999 Pappolla MA, Chyan YJ, Poeggeler B, Bozner P, Ghiso J, LeDoux SP, Wilson GL. Alzheimer beta protein mediated oxidative damage of mitochondrial DNA: prevention by melatonin. Journal of Pineal Research. 27: 226-9. PMID 10551770 DOI: 10.1111/J.1600-079X.1999.Tb00619.X  0.497
1999 Chyan YJ, Poeggeler B, Omar RA, Chain DG, Frangione B, Ghiso J, Pappolla MA. Potent neuroprotective properties against the Alzheimer beta-amyloid by an endogenous melatonin-related indole structure, indole-3-propionic acid. The Journal of Biological Chemistry. 274: 21937-42. PMID 10419516 DOI: 10.1074/Jbc.274.31.21937  0.617
1999 Nunomura A, Perry G, Pappolla MA, Wade R, Hirai K, Chiba S, Smith MA. RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 1959-64. PMID 10066249  0.722
1999 Poeggeler B, Pappolla MA, Hardeland R, Rassoulpour A, Hodgkins PS, Guidetti P, Schwarcz R. Indole-3-propionate: a potent hydroxyl radical scavenger in rat brain. Brain Research. 815: 382-8. PMID 9878843 DOI: 10.1016/S0006-8993(98)01027-0  0.309
1999 Nunomura A, Perry G, Pappolla MA, Wade R, Hirai K, Chiba S, Smith MA. RNA Oxidation Is a Prominent Feature of Vulnerable Neurons in Alzheimer’s Disease The Journal of Neuroscience. 19: 1959-1964. DOI: 10.1523/JNEUROSCI.19-06-01959.1999  0.708
1999 Pappolla MA, Chvan Y, Bozner P, Poeggeler B, Frangione B, Hsiao K, Omai RA, Perry G, Smith MA, Ghiso J. INDUCTION OF NAPH CYTOCHROME P450 REDUCTASE BY AMYLOID β PROTEIN Journal of Neuropathology and Experimental Neurology. 58: 531. DOI: 10.1097/00005072-199905000-00099  0.332
1998 Smith MA, Hirai K, Hsiao K, Pappolla MA, Harris PL, Siedlak SL, Tabaton M, Perry G. Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress. Journal of Neurochemistry. 70: 2212-5. PMID 9572310 DOI: 10.1046/J.1471-4159.1998.70052212.X  0.779
1998 Pappolla MA, Chyan YJ, Omar RA, Hsiao K, Perry G, Smith MA, Bozner P. Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: a chronic oxidative paradigm for testing antioxidant therapies in vivo. The American Journal of Pathology. 152: 871-7. PMID 9546346  0.588
1998 Pappolla M, Bozner P, Soto C, Shao H, Robakis NK, Zagorski M, Frangione B, Ghiso J. Inhibition of Alzheimer beta-fibrillogenesis by melatonin. The Journal of Biological Chemistry. 273: 7185-8. PMID 9516407 DOI: 10.1074/Jbc.273.13.7185  0.73
1997 Bozner P, Grishko V, LeDoux SP, Wilson GL, Chyan YC, Pappolla MA. The amyloid beta protein induces oxidative damage of mitochondrial DNA. Journal of Neuropathology and Experimental Neurology. 56: 1356-62. PMID 9413284 DOI: 10.1097/00005072-199712000-00010  0.425
1997 Pappolla MA, Sos M, Omar RA, Bick RJ, Hickson-Bick DL, Reiter RJ, Efthimiopoulos S, Robakis NK. Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 1683-90. PMID 9030627 DOI: 10.1523/Jneurosci.17-05-01683.1997  0.701
1997 Pappolla MA, Sos M, Omar RA, Bick RJ, Hickson-Bick DLM, Reiter RJ, Efthimiopoulos S, Robakis NK. Melatonin Prevents Death of Neuroblastoma Cells Exposed to the Alzheimer Amyloid Peptide The Journal of Neuroscience. 17: 1683-1690. DOI: 10.1523/JNEUROSCI.17-05-01683.1997  0.584
1997 Pappolla MA, Solo C, Bozner P, Franuione B, Ghiso J. MELATONIN PREVENTS FORMATION OF β-SHEETS AND FIBRILS OF P-AMYLOID. A NEW THERAPY FOR AD? Journal of Neuropathology and Experimental Neurology. 56: 575. DOI: 10.1097/00005072-199705000-00028  0.384
1997 Bozner L, Wilson G, Ledoux S, Chvan J, Pappolla MA. OXIDATIVE DAMAGE OF MITOCHODRIAL DNA IN PC 12 CELLS FOLLOWING EXPOSURE TO AN AMYLOID (3-PROTEIN Journal of Neuropathology and Experimental Neurology. 56: 574. DOI: 10.1097/00005072-199705000-00027  0.357
1996 Pappolla MA, Sos M, Omar RA, Sambamurti K. The heat shock/oxidative stress connection. Relevance to Alzheimer disease. Molecular and Chemical Neuropathology / Sponsored by the International Society For Neurochemistry and the World Federation of Neurology and Research Groups On Neurochemistry and Cerebrospinal Fluid. 28: 21-34. PMID 8871938 DOI: 10.1007/BF02815201  0.663
1996 Omar R, Smith M, Perry G, Pappolla M. IMUNOHISTOCHEMICAL EVIDENCE OF OXIDATIVE STRESS IN PARKINSONʼS DISEASE (PD) Journal of Neuropathology and Experimental Neurology. 55: 634. DOI: 10.1097/00005072-199605000-00127  0.57
1996 Pappolla M, Sos M, Reiter R, Sambamurti K, Omar R, Robakis N, Efthimiopoulos S. 589 Melatonin prevents oxidative damage and heat-shock protein induction in cultured cells exposed to the Alzheimer's amyloid beta protein (Aβ) Neurobiology of Aging. 17: S146-S147. DOI: 10.1016/S0197-4580(96)80591-4  0.802
1995 Pappolla MA, Sambamurti K, Efthimiopoulos S, Refolo L, Omar RA, Robakis NK. Heat-shock induces abnormalities in the cellular distribution of amyloid precursor protein (APP) and APP fusion proteins. Neuroscience Letters. 192: 105-8. PMID 7675314 DOI: 10.1016/0304-3940(95)11627-9  0.78
1995 Refolo LM, Sambamurti K, Efthimiopoulos S, Pappolla MA, Robakis NK. Evidence that secretase cleavage of cell surface Alzheimer amyloid precursor occurs after normal endocytic internalization. Journal of Neuroscience Research. 40: 694-706. PMID 7602619 DOI: 10.1002/Jnr.490400515  0.774
1995 Ogburn J, Sambamurti K, Wisniewski T, Franuione B, Dudley A, Pappolla M. COLLOID INCLUSIONS OF PARKINSONʼS DISEASE Journal of Neuropathology and Experimental Neurology. 54: 445. DOI: 10.1097/00005072-199505000-00152  0.571
1994 Robakis NK, Pappolla MA. Oxygen-free radicals and amyloidosis in Alzheimer's disease: is there a connection? Neurobiology of Aging. 15: 457-9; discussion 47. PMID 7969722 DOI: 10.1016/0197-4580(94)90077-9  0.537
1992 Sambamurti K, Shioi J, Anderson JP, Pappolla MA, Robakis NK. Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells. Journal of Neuroscience Research. 33: 319-29. PMID 1453494 DOI: 10.1002/jnr.490330216  0.725
1992 Pappolla MA, Omar RA, Sambamurti K, Anderson JP, Robakis NK. The genesis of the senile plaque. Further evidence in support of its neuronal origin. The American Journal of Pathology. 141: 1151-9. PMID 1443049  0.485
1992 Pappolla MA, Omar RA, Kim KS, Robakis NK. Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's disease. The American Journal of Pathology. 140: 621-8. PMID 1372157  0.485
1992 Sambamurti K, Refolo LM, Shioi J, Pappolla MA, Robakis NK. The Alzheimer's amyloid precursor is cleaved intracellularly in the trans-Golgi network or in a post-Golgi compartment. Annals of the New York Academy of Sciences. 674: 118-28. PMID 1283818 DOI: 10.1111/j.1749-6632.1992.tb27481.x  0.728
1987 Pappolla M, Penton R, Weiss HS, Miller CH, Sahenk Z, Autilio-Gambetti L, Gambetti P. Carbon disulfide axonopathy. Another experimental model characterized by acceleration of neurofilament transport and distinct changes of axonal size. Brain Research. 424: 272-80. PMID 2445451 DOI: 10.1016/0006-8993(87)91471-5  0.506
1986 Pappolla MA, Chou SM. UNILATERAL RHIZOTOMY PREVENTS AXONAL BALLOONING OF MOTONEURONS IN IDPN INTOXICATION Journal of Neuropathology and Experimental Neurology. 45: 352. DOI: 10.1097/00005072-198605000-00113  0.485
1984 Pappolla M, Monaco S, Weiss H, Miller C, Sahenk Z, Autillo-Gambetti L, Gambetti P. 38 Slow Axonal Transport In Carbon Disulfide (Cs2) Giant Axonopathy Journal of Neuropathology and Experimental Neurology. 43: 305. DOI: 10.1097/00005072-198405000-00047  0.506
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