Keisuke Hirai, PhD, Osaka University - Publications

Affiliations: 
Takeda Chemical Industries 
Area:
Neurodegenerative diseases

29 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Swarup V, Hinz FI, Rexach JE, Noguchi KI, Toyoshiba H, Oda A, Hirai K, Sarkar A, Seyfried NT, Cheng C, Haggarty SJ, Grossman M, Van Deerlin VM, Trojanowski JQ, et al. Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia. Nature Medicine. PMID 30510257 DOI: 10.1038/S41591-018-0223-3  0.329
2013 Ishigaki H, Itou H, Takeshima T, Kawai M, Hirai K, Shirai A, Horita A, Saitou I. [Henoch-Schönlein purpura developed after radical cystectomy]. Hinyokika Kiyo. Acta Urologica Japonica. 59: 663-7. PMID 24262708  0.36
2010 Fukumoto H, Takahashi H, Tarui N, Matsui J, Tomita T, Hirode M, Sagayama M, Maeda R, Kawamoto M, Hirai K, Terauchi J, Sakura Y, Kakihana M, Kato K, Iwatsubo T, et al. A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 11157-66. PMID 20720123 DOI: 10.1523/JNEUROSCI.2884-10.2010  0.313
2006 Nunomura A, Honda K, Takeda A, Hirai K, Zhu X, Smith MA, Perry G. Oxidative damage to RNA in neurodegenerative diseases. Journal of Biomedicine & Biotechnology. 2006: 82323. PMID 17047315 DOI: 10.1155/Jbb/2006/82323  0.813
2006 Zhu X, Perry G, Moreira PI, Aliev G, Cash AD, Hirai K, Smith MA. Mitochondrial abnormalities and oxidative imbalance in Alzheimer disease. Journal of Alzheimer's Disease : Jad. 9: 147-53. PMID 16873962 DOI: 10.3233/JAD-2006-9207  0.811
2003 Tateyama M, Takeda A, Onodera Y, Matsuzaki M, Hasegawa T, Nunomura A, Hirai K, Perry G, Smith MA, Itoyama Y. Oxidative stress and predominant Abeta42(43) deposition in myopathies with rimmed vacuoles. Acta Neuropathologica. 105: 581-5. PMID 12734664 DOI: 10.1007/S00401-003-0685-2  0.736
2002 Perry G, Nunomura A, Cash AD, Taddeo MA, Hirai K, Aliev G, Avila J, Wataya T, Shimohama S, Atwood CS, Smith MA. Reactive oxygen: its sources and significance in Alzheimer disease. Journal of Neural Transmission. Supplementum. 69-75. PMID 12456052 DOI: 10.1007/978-3-7091-6139-5_7  0.752
2002 Perry G, Nunomura A, Hirai K, Zhu X, Pérez M, Avila J, Castellani RJ, Atwood CS, Aliev G, Sayre LM, Takeda A, Smith MA. Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases? Free Radical Biology & Medicine. 33: 1475-9. PMID 12446204 DOI: 10.1016/S0891-5849(02)01113-9  0.834
2002 Castellani R, Hirai K, Aliev G, Drew KL, Nunomura A, Takeda A, Cash AD, Obrenovich ME, Perry G, Smith MA. Role of mitochondrial dysfunction in Alzheimer's disease. Journal of Neuroscience Research. 70: 357-60. PMID 12391597 DOI: 10.1002/Jnr.10389  0.804
2002 Kawanaka Y, Kobayashi K, Kusuda S, Tatsumi T, Murota M, Nishiyama T, Hisaichi K, Fujii A, Hirai K, Naka M, Komeno M, Nakai H, Toda M. Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. Part 1: synthesis and biological evaluation of dihydropyridin-2-imines. Bioorganic & Medicinal Chemistry Letters. 12: 2291-4. PMID 12161118 DOI: 10.1016/S0960-894X(02)00455-9  0.325
2002 Smith MA, Drew KL, Nunomura A, Takeda A, Hirai K, Zhu X, Atwood CS, Raina AK, Rottkamp CA, Sayre LM, Friedland RP, Perry G. Amyloid-beta, tau alterations and mitochondrial dysfunction in Alzheimer disease: the chickens or the eggs? Neurochemistry International. 40: 527-31. PMID 11850109 DOI: 10.1016/S0197-0186(01)00123-1  0.809
2002 Kawanaka Y, Kobayashi K, Kusuda S, Tatsumi T, Murota M, Nishiyama T, Hisaichi K, Fujii A, Hirai K, Naka M, Komeno M, Nakai H, Toda M. One Step Synthesis of Dihydropyridin-2-imines: Inhibitors of Inducible Nitric Oxide Synthase Synlett. 2002: 1233-1236. DOI: 10.1055/S-2002-32982  0.331
2001 Nunomura A, Perry G, Aliev G, Hirai K, Takeda A, Balraj EK, Jones PK, Ghanbari H, Wataya T, Shimohama S, Chiba S, Atwood CS, Petersen RB, Smith MA. Oxidative damage is the earliest event in Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 60: 759-67. PMID 11487050 DOI: 10.1093/Jnen/60.8.759  0.832
2001 Hirai K, Aliev G, Nunomura A, Fujioka H, Russell RL, Atwood CS, Johnson AB, Kress Y, Vinters HV, Tabaton M, Shimohama S, Cash AD, Siedlak SL, Harris PL, Jones PK, et al. Mitochondrial abnormalities in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 3017-23. PMID 11312286  0.836
2001 Hirai K, Aliev G, Nunomura A, Fujioka H, Russell RL, Atwood CS, Johnson AB, Kress Y, Vinters HV, Tabaton M, Shimohama S, Cash AD, Siedlak SL, Harris PLR, Jones PK, et al. Mitochondrial Abnormalities in Alzheimer's Disease The Journal of Neuroscience. 21: 3017-3023. DOI: 10.1523/Jneurosci.21-09-03017.2001  0.84
2000 Nunomura A, Perry G, Pappolla MA, Friedland RP, Hirai K, Chiba S, Smith MA. Neuronal oxidative stress precedes amyloid-beta deposition in Down syndrome. Journal of Neuropathology and Experimental Neurology. 59: 1011-7. PMID 11089579 DOI: 10.1093/Jnen/59.11.1011  0.799
2000 Rottkamp CA, Nunomura A, Hirai K, Sayre LM, Perry G, Smith MA. Will antioxidants fulfill their expectations for the treatment of Alzheimer disease? Mechanisms of Ageing and Development. 116: 169-79. PMID 10996017 DOI: 10.1016/S0047-6374(00)00124-X  0.778
2000 Perry G, Nunomura A, Hirai K, Takeda A, Aliev G, Smith MA. Oxidative damage in Alzheimer's disease: the metabolic dimension. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 18: 417-21. PMID 10817925 DOI: 10.1016/S0736-5748(00)00006-X  0.826
2000 Perry G, Hirai K, Aliev G, Nunomura A, Siedlak SL, Smith MA. Mitochondrial abnormalities in Alzheimer disease Neurobiology of Aging. 21: 213. DOI: 10.1016/S0197-4580(00)83289-3  0.778
1999 Nunomura A, Perry G, Hirai K, Aliev G, Takeda A, Chiba S, Smith MA. Neuronal RNA oxidation in Alzheimer's disease and Down's syndrome. Annals of the New York Academy of Sciences. 893: 362-4. PMID 10672267 DOI: 10.1111/J.1749-6632.1999.Tb07855.X  0.819
1999 Nunomura A, Perry G, Pappolla MA, Wade R, Hirai K, Chiba S, Smith MA. RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 1959-64. PMID 10066249  0.803
1999 Nunomura A, Perry G, Pappolla MA, Wade R, Hirai K, Chiba S, Smith MA. RNA Oxidation Is a Prominent Feature of Vulnerable Neurons in Alzheimer’s Disease The Journal of Neuroscience. 19: 1959-1964. DOI: 10.1523/JNEUROSCI.19-06-01959.1999  0.805
1999 Smith MA, Hirai K, Nunomura A, Perry G. Mitochondrial abnormalities: A primary basis for oxidative damage in Alzheimer's disease Drug Development Research. 46: 26-33. DOI: 10.1002/(SICI)1098-2299(199901)46:1<26::AID-DDR5>3.0.CO;2-8  0.803
1999 Smith MA, Hirai K, Nunomura A, Perry G. Mitochondrial abnormalities: A primary basis for oxidative damage in Alzheimer's disease Drug Development Research. 46: 26-33.  0.725
1998 Perry G, Castellani RJ, Hirai K, Smith MA. Reactive Oxygen Species Mediate Cellular Damage in Alzheimer Disease. Journal of Alzheimer's Disease : Jad. 1: 45-55. PMID 12214011 DOI: 10.3233/JAD-1998-1103  0.809
1998 Hirai K, Hayako H, Kato K, Miyamoto M. Idebenone protects hippocampal neurons against amyloid β-peptide- induced neurotoxicity in rat primary cultures Naunyn-Schmiedeberg's Archives of Pharmacology. 358: 582-585. PMID 9840428 DOI: 10.1007/Pl00005296  0.377
1998 Smith MA, Hirai K, Hsiao K, Pappolla MA, Harris PL, Siedlak SL, Tabaton M, Perry G. Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress. Journal of Neurochemistry. 70: 2212-5. PMID 9572310 DOI: 10.1046/J.1471-4159.1998.70052212.X  0.82
1998 Wade R, Hirai K, Perry G, A M. ACCUMULATION OF 8-HYDROXY-GUANOSINE IN NEURONAL CYTOPLASM INDICATES MITOCHONDRIAL DAMAGE AND RADICAL PRODUCTION ARE EARLY FEATURES OF ALZHEIMER DISEASE Journal of Neuropathology and Experimental Neurology. 57: 511. DOI: 10.1097/00005072-199805000-00186  0.675
1998 Hirai K, Smith MA, Wade R, Perry G. VULNERABLE NEURONS IN ALZHEIMER DISEASE ACCUMULATE MITOCHONDRIAL DNA WITH THE COMMON 5KB DELETION Journal of Neuropathology and Experimental Neurology. 57: 511. DOI: 10.1097/00005072-199805000-00185  0.658
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