Fritjof Helmchen - Publications

Affiliations: 
Brain Research Institute Universität Zürich, Zürich, ZH, Switzerland 
Area:
neural circuits

127 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Brandalise F, Carta S, Leone R, Helmchen F, Holtmaat A, Gerber U. Dendritic Branch-constrained N-Methyl-d-Aspartate Receptor-mediated Spikes Drive Synaptic Plasticity in Hippocampal CA3 Pyramidal Cells. Neuroscience. PMID 34634424 DOI: 10.1016/j.neuroscience.2021.10.002  0.796
2021 Rupprecht P, Carta S, Hoffmann A, Echizen M, Blot A, Kwan AC, Dan Y, Hofer SB, Kitamura K, Helmchen F, Friedrich RW. A database and deep learning toolbox for noise-optimized, generalized spike inference from calcium imaging. Nature Neuroscience. PMID 34341584 DOI: 10.1038/s41593-021-00895-5  0.8
2021 Schoenfeld G, Carta S, Rupprecht P, Ayaz A, Helmchen F. Calcium Imaging of CA3 Pyramidal Neuron Populations in Adult Mouse Hippocampus. Eneuro. 8. PMID 34330817 DOI: 10.1523/ENEURO.0023-21.2021  0.825
2020 Kastli R, Vighagen R, van der Bourg A, Argunsah AÖ, Iqbal A, Voigt FF, Kirschenbaum D, Aguzzi A, Helmchen F, Karayannis T. Developmental divergence of sensory stimulus representation in cortical interneurons. Nature Communications. 11: 5729. PMID 33184269 DOI: 10.1038/s41467-020-19427-z  0.816
2020 Gallero-Salas Y, Han S, Sych Y, Voigt FF, Laurenczy B, Gilad A, Helmchen F. Sensory and Behavioral Components of Neocortical Signal Flow in Discrimination Tasks with Short-Term Memory. Neuron. PMID 33159842 DOI: 10.1016/j.neuron.2020.10.017  0.796
2020 Banerjee A, Parente G, Teutsch J, Lewis C, Voigt FF, Helmchen F. Value-guided remapping of sensory cortex by lateral orbitofrontal cortex. Nature. PMID 32884146 DOI: 10.1038/S41586-020-2704-Z  0.805
2020 Renz AF, Lee J, Tybrandt K, Brzezinski M, Lorenzo DA, Cerra Cheraka M, Lee J, Helmchen F, Vörös J, Lewis CM. Opto-E-Dura: A Soft, Stretchable ECoG Array for Multimodal, Multiscale Neuroscience. Advanced Healthcare Materials. e2000814. PMID 32691992 DOI: 10.1002/Adhm.202000814  0.772
2020 Markicevic M, Fulcher BD, Lewis C, Helmchen F, Rudin M, Zerbi V, Wenderoth N. Cortical Excitation:Inhibition Imbalance Causes Abnormal Brain Network Dynamics as Observed in Neurodevelopmental Disorders. Cerebral Cortex (New York, N.Y. : 1991). PMID 32313923 DOI: 10.1093/Cercor/Bhaa084  0.58
2020 Gilad A, Helmchen F. Spatiotemporal refinement of signal flow through association cortex during learning. Nature Communications. 11: 1744. PMID 32269226 DOI: 10.1038/s41467-020-15534-z  0.301
2019 Omlor W, Wahl AS, Sipilä P, Lütcke H, Laurenczy B, Chen IW, Sumanovski LT, van 't Hoff M, Bethge P, Voigt FF, Schwab ME, Helmchen F. Context-dependent limb movement encoding in neuronal populations of motor cortex. Nature Communications. 10: 4812. PMID 31645554 DOI: 10.1038/S41467-019-12670-Z  0.78
2019 Voigt FF, Kirschenbaum D, Platonova E, Pagès S, Campbell RAA, Kastli R, Schaettin M, Egolf L, van der Bourg A, Bethge P, Haenraets K, Frézel N, Topilko T, Perin P, Hillier D, ... ... Helmchen F, et al. The mesoSPIM initiative: open-source light-sheet microscopes for imaging cleared tissue. Nature Methods. PMID 31527839 DOI: 10.1038/S41592-019-0554-0  0.77
2019 Mohan H, de Haan R, Broersen R, Pieneman AW, Helmchen F, Staiger JF, Mansvelder HD, de Kock CPJ. Functional architecture and encoding of tactile sensorimotor behavior in rat posterior parietal cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31332000 DOI: 10.1523/Jneurosci.0693-19.2019  0.6
2019 Ayaz A, Stäuble A, Hamada M, Wulf MA, Saleem AB, Helmchen F. Layer-specific integration of locomotion and sensory information in mouse barrel cortex. Nature Communications. 10: 2585. PMID 31197148 DOI: 10.1038/s41467-019-10564-8  0.668
2019 Sych Y, Chernysheva M, Sumanovski LT, Helmchen F. High-density multi-fiber photometry for studying large-scale brain circuit dynamics. Nature Methods. PMID 31086339 DOI: 10.1038/s41592-019-0400-4  0.356
2019 van der Bourg A, Yang JW, Stüttgen MC, Reyes-Puerta V, Helmchen F, Luhmann HJ. Temporal Refinement of Sensory-Evoked Activity across Layers in Developing Mouse Barrel Cortex. The European Journal of Neuroscience. PMID 30941846 DOI: 10.1111/ejn.14413  0.798
2019 Rocha MD, Düring DN, Bethge P, Voigt FF, Hildebrand S, Helmchen F, Pfeifer A, Hahnloser RHR, Gahr M. Tissue Clearing and Light Sheet Microscopy: Imaging the Unsectioned Adult Zebra Finch Brain at Cellular Resolution. Frontiers in Neuroanatomy. 13: 13. PMID 30837847 DOI: 10.3389/Fnana.2019.00013  0.32
2018 Gilad A, Gallero-Salas Y, Groos D, Helmchen F. Behavioral Strategy Determines Frontal or Posterior Location of Short-Term Memory in Neocortex. Neuron. 99: 814-828.e7. PMID 30100254 DOI: 10.1016/j.neuron.2018.07.029  0.367
2018 Mohan H, Gallero-Salas Y, Carta S, Sacramento J, Laurenczy B, Sumanovski LT, de Kock CPJ, Helmchen F, Sachidhanandam S. Sensory representation of an auditory cued tactile stimulus in the posterior parietal cortex of the mouse. Scientific Reports. 8: 7739. PMID 29773806 DOI: 10.1038/S41598-018-25891-X  0.813
2018 Schlegel F, Sych Y, Schroeter A, Stobart J, Weber B, Helmchen F, Rudin M. Fiber-optic implant for simultaneous fluorescence-based calcium recordings and BOLD fMRI in mice. Nature Protocols. 13: 840-855. PMID 29599439 DOI: 10.1038/nprot.2018.003  0.393
2018 Pilz GA, Bottes S, Betizeau M, Jörg DJ, Carta S, Simons BD, Helmchen F, Jessberger S. Live imaging of neurogenesis in the adult mouse hippocampus. Science (New York, N.Y.). 359: 658-662. PMID 29439238 DOI: 10.1126/Science.Aao5056  0.382
2018 Moeys DP, Corradi F, Li C, Bamford SA, Longinotti L, Voigt FF, Berry S, Taverni G, Helmchen F, Delbruck T. A Sensitive Dynamic and Active Pixel Vision Sensor for Color or Neural Imaging Applications. Ieee Transactions On Biomedical Circuits and Systems. 12: 123-136. PMID 29377801 DOI: 10.1109/TBCAS.2017.2759783  0.305
2017 Muir DR, Molina-Luna P, Roth MM, Helmchen F, Kampa BM. Specific excitatory connectivity for feature integration in mouse primary visual cortex. Plos Computational Biology. 13: e1005888. PMID 29240769 DOI: 10.1371/Journal.Pcbi.1005888  0.775
2017 Wahl AS, Büchler U, Brändli A, Brattoli B, Musall S, Kasper H, Ineichen BV, Helmchen F, Ommer B, Schwab ME. Optogenetically stimulating intact rat corticospinal tract post-stroke restores motor control through regionalized functional circuit formation. Nature Communications. 8: 1187. PMID 29084962 DOI: 10.1038/S41467-017-01090-6  0.794
2017 Helmchen F, Gilad A, Chen JL. Neocortical Dynamics during Whisker-based Sensory Discrimination in Head-Restrained Mice. Neuroscience. PMID 28919043 DOI: 10.1016/J.Neuroscience.2017.09.003  0.553
2017 Voigt FF, Emaury F, Bethge P, Waldburger D, Link SM, Carta S, van der Bourg A, Helmchen F, Keller U. Multiphoton in vivo imaging with a femtosecond semiconductor disk laser. Biomedical Optics Express. 8: 3213-3231. PMID 28717563 DOI: 10.1364/Boe.8.003213  0.772
2017 Bethge P, Carta S, Lorenzo DA, Egolf L, Goniotaki D, Madisen L, Voigt FF, Chen JL, Schneider B, Ohkura M, Nakai J, Zeng H, Aguzzi A, Helmchen F. An R-CaMP1.07 reporter mouse for cell-type-specific expression of a sensitive red fluorescent calcium indicator. Plos One. 12: e0179460. PMID 28640817 DOI: 10.1371/Journal.Pone.0179460  0.794
2017 Keller AJ, Houlton R, Kampa BM, Lesica NA, Mrsic-Flogel TD, Keller GB, Helmchen F. Stimulus relevance modulates contrast adaptation in visual cortex. Elife. 6. PMID 28130922 DOI: 10.7554/Elife.21589  0.775
2016 Brandalise F, Carta S, Helmchen F, Lisman J, Gerber U. Dendritic NMDA spikes are necessary for timing-dependent associative LTP in CA3 pyramidal cells. Nature Communications. 7: 13480. PMID 27848967 DOI: 10.1038/Ncomms13480  0.789
2016 van der Bourg A, Yang JW, Reyes-Puerta V, Laurenczy B, Wieckhorst M, Stüttgen MC, Luhmann HJ, Helmchen F. Layer-Specific Refinement of Sensory Coding in Developing Mouse Barrel Cortex. Cerebral Cortex (New York, N.Y. : 1991). PMID 27620976 DOI: 10.1093/Cercor/Bhw280  0.804
2016 Pilz GA, Carta S, Stäuble A, Ayaz A, Jessberger S, Helmchen F. Functional Imaging of Dentate Granule Cells in the Adult Mouse Hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 7407-14. PMID 27413151 DOI: 10.1523/Jneurosci.3065-15.2016  0.658
2016 Chen JL, Voigt FF, Javadzadeh M, Krueppel R, Helmchen F. Long-Range population dynamics of anatomically defined neocortical networks. Elife. 5. PMID 27218452 DOI: 10.7554/Elife.14679  0.82
2016 Leitner FC, Melzer S, Lütcke H, Pinna R, Seeburg PH, Helmchen F, Monyer H. Spatially segregated feedforward and feedback neurons support differential odor processing in the lateral entorhinal cortex. Nature Neuroscience. PMID 27182817 DOI: 10.1038/Nn.4303  0.41
2016 Keller AJ, Houlton R, Kampa BM, Lesica NA, Mrsic-Flogel TD, Keller GB, Helmchen F. Author response: Stimulus relevance modulates contrast adaptation in visual cortex Elife. DOI: 10.7554/Elife.21589.012  0.758
2016 Chen JL, Voigt FF, Javadzadeh M, Krueppel R, Helmchen F. Author response: Long-range population dynamics of anatomically defined neocortical networks Elife. DOI: 10.7554/Elife.14679.024  0.767
2015 Chen IW, Helmchen F, Lütcke H. Specific Early and Late Oddball-Evoked Responses in Excitatory and Inhibitory Neurons of Mouse Auditory Cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 12560-73. PMID 26354921 DOI: 10.1523/Jneurosci.2240-15.2015  0.616
2015 Muir DR, Roth MM, Helmchen F, Kampa BM. Model-based analysis of pattern motion processing in mouse primary visual cortex. Frontiers in Neural Circuits. 9: 38. PMID 26300738 DOI: 10.3389/Fncir.2015.00038  0.813
2015 Chen JL, Margolis DJ, Stankov A, Sumanovski LT, Schneider BL, Helmchen F. Pathway-specific reorganization of projection neurons in somatosensory cortex during learning. Nature Neuroscience. PMID 26098757 DOI: 10.1038/Nn.4046  0.644
2015 Mayrhofer JM, Haiss F, Helmchen F, Weber B. Sparse, reliable, and long-term stable representation of periodic whisker deflections in the mouse barrel cortex. Neuroimage. 115: 52-63. PMID 25934471 DOI: 10.1016/j.neuroimage.2015.04.045  0.788
2015 Madisen L, Garner AR, Shimaoka D, Chuong AS, Klapoetke NC, Li L, van der Bourg A, Niino Y, Egolf L, Monetti C, Gu H, Mills M, Cheng A, Tasic B, Nguyen TN, ... ... Helmchen F, et al. Transgenic mice for intersectional targeting of neural sensors and effectors with high specificity and performance. Neuron. 85: 942-58. PMID 25741722 DOI: 10.1016/J.Neuron.2015.02.022  0.785
2015 Helmchen F, Tank DW. A single-compartment model of calcium dynamics in nerve terminals and dendrites. Cold Spring Harbor Protocols. 2015: 155-67. PMID 25646507 DOI: 10.1101/pdb.top085910  0.612
2015 Muir DR, Roth MM, Helmchen F, Kampa BM. Model-based analysis of pattern motion processing in mouse primary visual cortex Frontiers in Neural Circuits. 9. DOI: 10.3389/fncir.2015.00038  0.771
2015 Helmchen F, Voigt FF, Chen JL. In vivo calcium imaging of information processing in mouse neocortex during behavior Optics and the Brain, Brain 2015. DOI: 10.1364/Ntm.2015.Jt1B.1  0.572
2015 Voigt FF, Chen JL, Krüppel R, Helmchen F. A modular two-photon microscope for simultaneous imaging of distant cortical areas in vivo Progress in Biomedical Optics and Imaging - Proceedings of Spie. 9329. DOI: 10.1117/12.2076388  0.583
2015 Mayrhofer JM, Haiss F, Helmchen F, Weber B. Sparse, reliable, and long-term stable representation of periodic whisker deflections in the mouse barrel cortex Neuroimage. 115: 52-63. DOI: 10.1016/j.neuroimage.2015.04.045  0.699
2014 Musall S, von der Behrens W, Mayrhofer JM, Weber B, Helmchen F, Haiss F. Tactile frequency discrimination is enhanced by circumventing neocortical adaptation. Nature Neuroscience. 17: 1567-73. PMID 25242306 DOI: 10.1038/Nn.3821  0.786
2014 Wahl AS, Omlor W, Rubio JC, Chen JL, Zheng H, Schröter A, Gullo M, Weinmann O, Kobayashi K, Helmchen F, Ommer B, Schwab ME. Neuronal repair. Asynchronous therapy restores motor control by rewiring of the rat corticospinal tract after stroke. Science (New York, N.Y.). 344: 1250-5. PMID 24926013 DOI: 10.1126/Science.1253050  0.474
2014 Grewe BF, Helmchen F. High-speed two-photon calcium imaging of neuronal population activity using acousto-optic deflectors. Cold Spring Harbor Protocols. 2014: 618-29. PMID 24890212 DOI: 10.1101/pdb.prot081778  0.757
2014 Margolis DJ, Lütcke H, Helmchen F. Microcircuit dynamics of map plasticity in barrel cortex. Current Opinion in Neurobiology. 24: 76-81. PMID 24492082 DOI: 10.1016/J.Conb.2013.08.019  0.572
2014 Grewe BF, Helmchen F, Kampa BM. Two-photon imaging of neuronal network dynamics in neocortex Neuromethods. 85: 133-150. DOI: 10.1007/978-1-62703-785-3_9  0.811
2014 Margolis DJ, Lütcke H, Helmchen F, Weber B, Haiss F. Chronic two-photon imaging of neural activity in the anesthetized and awake behaving rodent Neuromethods. 85: 151-173. DOI: 10.1007/978-1-62703-785-3_10  0.758
2013 Lütcke H, Gerhard F, Zenke F, Gerstner W, Helmchen F. Inference of neuronal network spike dynamics and topology from calcium imaging data. Frontiers in Neural Circuits. 7: 201. PMID 24399936 DOI: 10.3389/Fncir.2013.00201  0.416
2013 Graber MH, Helmchen F, Hahnloser RH. Activity in a premotor cortical nucleus of zebra finches is locally organized and exhibits auditory selectivity in neurons but not in glia. Plos One. 8: e81177. PMID 24312533 DOI: 10.1371/journal.pone.0081177  0.46
2013 Devor A, Bandettini PA, Boas DA, Bower JM, Buxton RB, Cohen LB, Dale AM, Einevoll GT, Fox PT, Franceschini MA, Friston KJ, Fujimoto JG, Geyer MA, Greenberg JH, Halgren E, ... ... Helmchen F, et al. The challenge of connecting the dots in the B.R.A.I.N. Neuron. 80: 270-4. PMID 24139032 DOI: 10.1016/J.Neuron.2013.09.008  0.762
2013 Helmchen F, Denk W, Kerr JN. Miniaturization of two-photon microscopy for imaging in freely moving animals. Cold Spring Harbor Protocols. 2013: 904-13. PMID 24086055 DOI: 10.1101/pdb.top078147  0.816
2013 Chen JL, Pfäffli OA, Voigt FF, Margolis DJ, Helmchen F. Online correction of licking-induced brain motion during two-photon imaging with a tunable lens. The Journal of Physiology. 591: 4689-98. PMID 23940380 DOI: 10.1113/Jphysiol.2013.259804  0.668
2013 Chen JL, Carta S, Soldado-Magraner J, Schneider BL, Helmchen F. Behaviour-dependent recruitment of long-range projection neurons in somatosensory cortex. Nature. 499: 336-40. PMID 23792559 DOI: 10.1038/Nature12236  0.579
2013 Lütcke H, Margolis DJ, Helmchen F. Steady or changing? Long-term monitoring of neuronal population activity. Trends in Neurosciences. 36: 375-84. PMID 23608298 DOI: 10.1016/J.Tins.2013.03.008  0.573
2013 Langer D, van 't Hoff M, Keller AJ, Nagaraja C, Pfäffli OA, Göldi M, Kasper H, Helmchen F. HelioScan: a software framework for controlling in vivo microscopy setups with high hardware flexibility, functional diversity and extendibility. Journal of Neuroscience Methods. 215: 38-52. PMID 23416135 DOI: 10.1016/J.Jneumeth.2013.02.006  0.789
2013 Feldmeyer D, Brecht M, Helmchen F, Petersen CC, Poulet JF, Staiger JF, Luhmann HJ, Schwarz C. Barrel cortex function. Progress in Neurobiology. 103: 3-27. PMID 23195880 DOI: 10.1016/J.Pneurobio.2012.11.002  0.592
2013 Johannssen HC, Helmchen F. Two-photon imaging of spinal cord cellular networks. Experimental Neurology. 242: 18-26. PMID 22849822 DOI: 10.1016/j.expneurol.2012.07.014  0.365
2013 Helmchen F, Hübener M. Neuronale Netzwerke im Rampenlicht: Mit leuchtenden Proteinen zelluläre Aktivitätsmuster entschlüsseln E-Neuroforum. 19. DOI: 10.1515/nf-2013-0203  0.457
2013 Helmchen F, Hübener M. Neuronal networks in the spotlight E-Neuroforum. 19. DOI: 10.1007/s13295-013-0042-4  0.464
2012 Margolis DJ, Lütcke H, Schulz K, Haiss F, Weber B, Kügler S, Hasan MT, Helmchen F. Reorganization of cortical population activity imaged throughout long-term sensory deprivation. Nature Neuroscience. 15: 1539-46. PMID 23086335 DOI: 10.1038/Nn.3240  0.811
2012 Roth MM, Helmchen F, Kampa BM. Distinct functional properties of primary and posteromedial visual area of mouse neocortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 9716-26. PMID 22787057 DOI: 10.1523/JNEUROSCI.0110-12.2012  0.787
2012 Coiret G, Ster J, Grewe B, Wendling F, Helmchen F, Gerber U, Benquet P. Neuron to astrocyte communication via cannabinoid receptors is necessary for sustained epileptiform activity in rat hippocampus. Plos One. 7: e37320. PMID 22615976 DOI: 10.1371/Journal.Pone.0037320  0.788
2012 Schulz K, Sydekum E, Krueppel R, Engelbrecht CJ, Schlegel F, Schröter A, Rudin M, Helmchen F. Simultaneous BOLD fMRI and fiber-optic calcium recording in rat neocortex. Nature Methods. 9: 597-602. PMID 22561989 DOI: 10.1038/Nmeth.2013  0.812
2012 Farinelli M, Heitz FD, Grewe BF, Tyagarajan SK, Helmchen F, Mansuy IM. Selective regulation of NR2B by protein phosphatase-1 for the control of the NMDA receptor in neuroprotection. Plos One. 7: e34047. PMID 22479519 DOI: 10.1371/Journal.Pone.0034047  0.704
2012 Nimmerjahn A, Helmchen F. In vivo labeling of cortical astrocytes with sulforhodamine 101 (SR101). Cold Spring Harbor Protocols. 2012: 326-34. PMID 22383644 DOI: 10.1101/Pdb.Prot068155  0.788
2012 Langer D, Helmchen F. Post hoc immunostaining of GABAergic neuronal subtypes following in vivo two-photon calcium imaging in mouse neocortex. PflüGers Archiv : European Journal of Physiology. 463: 339-54. PMID 22134770 DOI: 10.1007/S00424-011-1048-9  0.667
2012 Minderer M, Liu W, Sumanovski LT, Kügler S, Helmchen F, Margolis DJ. Chronic imaging of cortical sensory map dynamics using a genetically encoded calcium indicator. The Journal of Physiology. 590: 99-107. PMID 22083602 DOI: 10.1113/Jphysiol.2011.219014  0.743
2011 Kampa BM, Roth MM, Göbel W, Helmchen F. Representation of visual scenes by local neuronal populations in layer 2/3 of mouse visual cortex. Frontiers in Neural Circuits. 5: 18. PMID 22180739 DOI: 10.3389/fncir.2011.00018  0.795
2011 Kampa BM, Göbel W, Helmchen F. Measuring neuronal population activity using 3D laser scanning. Cold Spring Harbor Protocols. 2011: 1340-9. PMID 22046041 DOI: 10.1101/pdb.prot066597  0.756
2011 Helmchen F. Calibration of fluorescent calcium indicators. Cold Spring Harbor Protocols. 2011: 923-30. PMID 21807862 DOI: 10.1101/pdb.top120  0.337
2011 Grewe BF, Voigt FF, van 't Hoff M, Helmchen F. Fast two-layer two-photon imaging of neuronal cell populations using an electrically tunable lens. Biomedical Optics Express. 2: 2035-46. PMID 21750778 DOI: 10.1364/BOE.2.002035  0.82
2011 Ster J, Mateos JM, Grewe BF, Coiret G, Corti C, Corsi M, Helmchen F, Gerber U. Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors. Proceedings of the National Academy of Sciences of the United States of America. 108: 9993-7. PMID 21628565 DOI: 10.1073/Pnas.1100548108  0.785
2011 Lütcke H, Helmchen F. Two-photon imaging and analysis of neural network dynamics Reports On Progress in Physics. 74. DOI: 10.1088/0034-4885/74/8/086602  0.449
2010 Ruchty M, Helmchen F, Wehner R, Kleineidam CJ. Representation of thermal information in the antennal lobe of leaf-cutting ants. Frontiers in Behavioral Neuroscience. 4: 174. PMID 21120133 DOI: 10.3389/fnbeh.2010.00174  0.371
2010 Johannssen HC, Helmchen F. In vivo Ca2+ imaging of dorsal horn neuronal populations in mouse spinal cord. The Journal of Physiology. 588: 3397-402. PMID 20660563 DOI: 10.1113/jphysiol.2010.191833  0.339
2010 Lütcke H, Murayama M, Hahn T, Margolis DJ, Astori S, Zum Alten Borgloh SM, Göbel W, Yang Y, Tang W, Kügler S, Sprengel R, Nagai T, Miyawaki A, Larkum ME, Helmchen F, et al. Optical recording of neuronal activity with a genetically-encoded calcium indicator in anesthetized and freely moving mice. Frontiers in Neural Circuits. 4: 9. PMID 20461230 DOI: 10.3389/Fncir.2010.00009  0.813
2010 Engelbrecht CJ, Voigt F, Helmchen F. Miniaturized selective plane illumination microscopy for high-contrast in vivo fluorescence imaging. Optics Letters. 35: 1413-5. PMID 20436587 DOI: 10.1364/OL.35.001413  0.764
2010 Grewe BF, Langer D, Kasper H, Kampa BM, Helmchen F. High-speed in vivo calcium imaging reveals neuronal network activity with near-millisecond precision. Nature Methods. 7: 399-405. PMID 20400966 DOI: 10.1038/Nmeth.1453  0.837
2010 Lee CM, Engelbrecht CJ, Soper TD, Helmchen F, Seibel EJ. Scanning fiber endoscopy with highly flexible, 1 mm catheterscopes for wide-field, full-color imaging. Journal of Biophotonics. 3: 385-407. PMID 20336702 DOI: 10.1002/Jbio.200900087  0.745
2010 Göbel W, Kampa BM, Helmchen F. In vivo imaging of cellular network signaling Handbook of Cell Signaling, 2/E. 3: 2753-2757. DOI: 10.1016/B978-0-12-374145-5.00321-1  0.703
2009 Grewe BF, Helmchen F. Optical probing of neuronal ensemble activity. Current Opinion in Neurobiology. 19: 520-9. PMID 19854041 DOI: 10.1016/j.conb.2009.09.003  0.76
2009 Engelbrecht CJ, Göbel W, Helmchen F. Enhanced fluorescence signal in nonlinear microscopy through supplementary fiber-optic light collection. Optics Express. 17: 6421-35. PMID 19365467 DOI: 10.1364/OE.17.006421  0.75
2009 Hoogland TM, Kuhn B, Göbel W, Huang W, Nakai J, Helmchen F, Flint J, Wang SS. Radially expanding transglial calcium waves in the intact cerebellum. Proceedings of the National Academy of Sciences of the United States of America. 106: 3496-501. PMID 19211787 DOI: 10.1073/Pnas.0809269106  0.766
2008 Helmchen F, Kleinfeld D. Chapter 10. In vivo measurements of blood flow and glial cell function with two-photon laser-scanning microscopy. Methods in Enzymology. 444: 231-54. PMID 19007667 DOI: 10.1016/S0076-6879(08)02810-3  0.359
2008 Helmchen F, Petersen CC. New views into the brain of mice on the move. Nature Methods. 5: 925-6. PMID 18974733 DOI: 10.1038/Nmeth1108-925  0.32
2008 Engelbrecht CJ, Johnston RS, Seibel EJ, Helmchen F. Ultra-compact fiber-optic two-photon microscope for functional fluorescence imaging in vivo. Optics Express. 16: 5556-64. PMID 18542658 DOI: 10.1364/Oe.16.005556  0.772
2007 Göbel W, Helmchen F. In vivo calcium imaging of neural network function. Physiology (Bethesda, Md.). 22: 358-65. PMID 18073408 DOI: 10.1152/physiol.00032.2007  0.387
2007 Kerr JN, de Kock CP, Greenberg DS, Bruno RM, Sakmann B, Helmchen F. Spatial organization of neuronal population responses in layer 2/3 of rat barrel cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 13316-28. PMID 18045926 DOI: 10.1523/JNEUROSCI.2210-07.2007  0.807
2007 Göbel W, Helmchen F. New angles on neuronal dendrites in vivo. Journal of Neurophysiology. 98: 3770-9. PMID 17898141 DOI: 10.1152/jn.00850.2007  0.452
2007 Larkum ME, Waters J, Sakmann B, Helmchen F. Dendritic spikes in apical dendrites of neocortical layer 2/3 pyramidal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 8999-9008. PMID 17715337 DOI: 10.1523/JNEUROSCI.1717-07.2007  0.806
2007 Helmchen F, Nevian T. Little strokes fill big oaks: a simple in vivo stain of brain cells. Neuron. 53: 771-3. PMID 17359911 DOI: 10.1016/j.neuron.2007.03.001  0.777
2007 Nevian T, Helmchen F. Calcium indicator loading of neurons using single-cell electroporation. PflüGers Archiv : European Journal of Physiology. 454: 675-88. PMID 17334778 DOI: 10.1007/s00424-007-0234-2  0.763
2007 Göbel W, Kampa BM, Helmchen F. Imaging cellular network dynamics in three dimensions using fast 3D laser scanning. Nature Methods. 4: 73-9. PMID 17143280 DOI: 10.1038/nmeth989  0.747
2006 Waters J, Helmchen F. Background synaptic activity is sparse in neocortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 8267-77. PMID 16899721 DOI: 10.1523/JNEUROSCI.2152-06.2006  0.541
2006 Helmchen F, Denk W. Erratum: Corrigendum: Deep tissue two-photon microscopy Nature Methods. 3: 235-235. DOI: 10.1038/NMETH0306-235  0.624
2005 Helmchen F, Denk W. Deep tissue two-photon microscopy. Nature Methods. 2: 932-40. PMID 16299478 DOI: 10.1038/nmeth818  0.667
2005 Kerr JN, Greenberg D, Helmchen F. Imaging input and output of neocortical networks in vivo. Proceedings of the National Academy of Sciences of the United States of America. 102: 14063-8. PMID 16157876 DOI: 10.1073/pnas.0506029102  0.825
2005 Sullivan MR, Nimmerjahn A, Sarkisov DV, Helmchen F, Wang SS. In vivo calcium imaging of circuit activity in cerebellar cortex. Journal of Neurophysiology. 94: 1636-44. PMID 16079125 DOI: 10.1152/Jn.01013.2004  0.816
2005 Nimmerjahn A, Kirchhoff F, Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science (New York, N.Y.). 308: 1314-8. PMID 15831717 DOI: 10.1515/Nf-2005-0304  0.778
2005 Broser PJ, Schulte R, Roth A, Helmchen F, Waters J, Lang S, Sakmann B, Wittum G. Nonlinear anisotropic diffusion filtering of three-dimensional image data from 2-photon microscopy Proceedings of Spie - the International Society For Optical Engineering. 5672: 44-69. DOI: 10.1117/12.593376  0.657
2004 Nimmerjahn A, Kirchhoff F, Kerr JN, Helmchen F. Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo. Nature Methods. 1: 31-7. PMID 15782150 DOI: 10.1038/Nmeth706  0.806
2004 Dittgen T, Nimmerjahn A, Komai S, Licznerski P, Waters J, Margrie TW, Helmchen F, Denk W, Brecht M, Osten P. Lentivirus-based genetic manipulations of cortical neurons and their optical and electrophysiological monitoring in vivo. Proceedings of the National Academy of Sciences of the United States of America. 101: 18206-11. PMID 15608064 DOI: 10.1073/Pnas.0407976101  0.816
2004 Waters J, Helmchen F. Boosting of action potential backpropagation by neocortical network activity in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 11127-36. PMID 15590929 DOI: 10.1523/JNEUROSCI.2933-04.2004  0.559
2004 Göbel W, Kerr JN, Nimmerjahn A, Helmchen F. Miniaturized two-photon microscope based on a flexible coherent fiber bundle and a gradient-index lens objective. Optics Letters. 29: 2521-3. PMID 15584281 DOI: 10.1364/Ol.29.002521  0.773
2004 Broser PJ, Schulte R, Lang S, Roth A, Helmchen F, Waters J, Sakmann B, Wittum G. Nonlinear anisotropic diffusion filtering of three-dimensional image data from two-photon microscopy. Journal of Biomedical Optics. 9: 1253-64. PMID 15574067 DOI: 10.1117/1.1806832  0.806
2004 Brecht M, Fee MS, Garaschuk O, Helmchen F, Margrie TW, Svoboda K, Osten P. Novel approaches to monitor and manipulate single neurons in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 9223-7. PMID 15496655 DOI: 10.1523/JNEUROSCI.3344-04.2004  0.767
2004 Göbel W, Nimmerjahn A, Helmchen F. Distortion-free delivery of nanojoule femtosecond pulses from a Ti:sapphire laser through a hollow-core photonic crystal fiber. Optics Letters. 29: 1285-7. PMID 15209273 DOI: 10.1364/Ol.29.001285  0.766
2004 Kim J, Dittgen T, Nimmerjahn A, Waters J, Pawlak V, Helmchen F, Schlesinger S, Seeburg PH, Osten P. Sindbis vector SINrep(nsP2S726): a tool for rapid heterologous expression with attenuated cytotoxicity in neurons. Journal of Neuroscience Methods. 133: 81-90. PMID 14757348 DOI: 10.1016/J.Jneumeth.2003.09.029  0.787
2004 Helmchen F, Göbel W, Nimmerjahn A. Fiber-optic two-photon-excited fluorescence microscopy Frontiers in Optics. DOI: 10.1364/Fio.2004.Fwf4  0.775
2003 Waters J, Larkum M, Sakmann B, Helmchen F. Supralinear Ca2+ influx into dendritic tufts of layer 2/3 neocortical pyramidal neurons in vitro and in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 8558-67. PMID 13679425 DOI: 10.1523/Jneurosci.23-24-08558.2003  0.805
2002 Helmchen F, Denk W. New developments in multiphoton microscopy. Current Opinion in Neurobiology. 12: 593-601. PMID 12367641 DOI: 10.1016/S0959-4388(02)00362-8  0.683
2002 Helmchen F, Waters J. Ca2+ imaging in the mammalian brain in vivo. European Journal of Pharmacology. 447: 119-29. PMID 12151004 DOI: 10.1016/S0014-2999(02)01836-8  0.542
2002 Helmchen F, Tank DW, Denk W. Enhanced two-photon excitation through optical fiber by single-mode propagation in a large core. Applied Optics. 41: 2930-4. PMID 12027181 DOI: 10.1364/Ao.41.002930  0.722
2001 Helmchen F, Fee MS, Tank DW, Denk W. A miniature head-mounted two-photon microscope. high-resolution brain imaging in freely moving animals. Neuron. 31: 903-12. PMID 11580892 DOI: 10.1016/S0896-6273(01)00421-4  0.777
1999 Helmchen F, Svoboda K, Denk W, Tank DW. In vivo dendritic calcium dynamics in deep-layer cortical pyramidal neurons. Nature Neuroscience. 2: 989-96. PMID 10526338 DOI: 10.1038/14788  0.803
1999 Svoboda K, Helmchen F, Denk W, Tank DW. Spread of dendritic excitation in layer 2/3 pyramidal neurons in rat barrel cortex in vivo. Nature Neuroscience. 2: 65-73. PMID 10195182 DOI: 10.1038/4569  0.804
1998 Kleinfeld D, Mitra PP, Helmchen F, Denk W. Fluctuations and stimulus-induced changes in blood flow observed in individual capillaries in layers 2 through 4 of rat neocortex. Proceedings of the National Academy of Sciences of the United States of America. 95: 15741-6. PMID 9861040 DOI: 10.1073/pnas.95.26.15741  0.666
1998 Bollmann JH, Helmchen F, Borst JG, Sakmann B. Postsynaptic Ca2+ influx mediated by three different pathways during synaptic transmission at a calyx-type synapse. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 10409-19. PMID 9852578 DOI: 10.1523/Jneurosci.18-24-10409.1998  0.772
1998 Borst JG, Helmchen F. Calcium influx during an action potential. Methods in Enzymology. 293: 352-71. PMID 9711618 DOI: 10.1016/S0076-6879(98)93023-3  0.609
1998 Markram H, Roth A, Helmchen F. Competitive calcium binding: implications for dendritic calcium signaling. Journal of Computational Neuroscience. 5: 331-48. PMID 9663555 DOI: 10.1023/A:1008891229546  0.753
1997 Helmchen F, Borst JG, Sakmann B. Calcium dynamics associated with a single action potential in a CNS presynaptic terminal. Biophysical Journal. 72: 1458-71. PMID 9138591 DOI: 10.1016/S0006-3495(97)78792-7  0.736
1996 Helmchen F, Imoto K, Sakmann B. Ca2+ buffering and action potential-evoked Ca2+ signaling in dendrites of pyramidal neurons. Biophysical Journal. 70: 1069-81. PMID 8789126 DOI: 10.1016/S0006-3495(96)79653-4  0.661
1995 Borst JG, Helmchen F, Sakmann B. Pre- and postsynaptic whole-cell recordings in the medial nucleus of the trapezoid body of the rat. The Journal of Physiology. 489: 825-40. PMID 8788946 DOI: 10.1113/jphysiol.1995.sp021095  0.735
1995 Schiller J, Helmchen F, Sakmann B. Spatial profile of dendritic calcium transients evoked by action potentials in rat neocortical pyramidal neurones. The Journal of Physiology. 487: 583-600. PMID 8544123 DOI: 10.1113/Jphysiol.1995.Sp020902  0.739
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