William H. Klein - Publications

Affiliations: 
M.D. Anderson Cancer Center, Houston, TX, United States 

139 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Zullo JM, Drake D, Aron L, O'Hern P, Dhamne SC, Davidsohn N, Mao CA, Klein WH, Rotenberg A, Bennett DA, Church GM, Colaiácovo MP, Yankner BA. Regulation of lifespan by neural excitation and REST. Nature. 574: 359-364. PMID 31619788 DOI: 10.1038/s41586-019-1647-8  0.4
2019 Kiyama T, Long Y, Chen CK, Whitaker CM, Shay A, Wu H, Badea TC, Mohsenin A, Parker-Thornburg J, Klein WH, Mills SL, Massey SC, Mao CA. Essential Roles of Tbr1 in the Formation and Maintenance of the Orientation-Selective J-RGCs and a Group of OFF-Sustained RGCs in Mouse. Cell Reports. 27: 900-915.e5. PMID 30995485 DOI: 10.1016/j.celrep.2019.03.077  0.4
2018 Kiyama T, Chen CK, Wang SW, Pan P, Ju Z, Wang J, Takada S, Klein WH, Mao CA. Essential roles of mitochondrial biogenesis regulator Nrf1 in retinal development and homeostasis. Molecular Neurodegeneration. 13: 56. PMID 30333037 DOI: 10.1186/s13024-018-0287-z  0.4
2017 Zhang Q, Zagozewski J, Cheng S, Dixit R, Zhang S, de Melo J, Mu X, Klein WH, Brown NL, Wigle JT, Schuurmans C, Eisenstat DD. Regulation of Brn3b by Dlx1 and Dlx2 is required for retinal ganglion cell differentiation in the vertebrate retina. Development (Cambridge, England). PMID 28356311 DOI: 10.1242/dev.142042  1
2016 Mao CA, Agca C, Mocko-Strand JA, Wang J, Ullrich-Lüter E, Pan P, Wang SW, Arnone MI, Frishman LJ, Klein WH. Substituting mouse transcription factor Pou4f2 with a sea urchin orthologue restores retinal ganglion cell development. Proceedings. Biological Sciences / the Royal Society. 283. PMID 26962139 DOI: 10.1098/rspb.2015.2978  1
2015 Martinet V, Tonon S, Torres D, Azouz A, Nguyen M, Kohler A, Flamand V, Mao CA, Klein WH, Leo O, Goriely S. Type I interferons regulate eomesodermin expression and the development of unconventional memory CD8(+) T cells. Nature Communications. 6: 7089. PMID 25953241 DOI: 10.1038/ncomms8089  1
2014 Joyal JS, Nim S, Zhu T, Sitaras N, Rivera JC, Shao Z, Sapieha P, Hamel D, Sanchez M, Zaniolo K, St-Louis M, Ouellette J, Montoya-Zavala M, Zabeida A, Picard E, ... ... Klein W, et al. Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis. Nature Medicine. 20: 1165-73. PMID 25216639 DOI: 10.1038/nm.3669  1
2014 Gao Z, Mao CA, Pan P, Mu X, Klein WH. Transcriptome of Atoh7 retinal progenitor cells identifies new Atoh7-dependent regulatory genes for retinal ganglion cell formation. Developmental Neurobiology. 74: 1123-40. PMID 24799426 DOI: 10.1002/dneu.22188  1
2013 Ehrman LA, Mu X, Waclaw RR, Yoshida Y, Vorhees CV, Klein WH, Campbell K. The LIM homeobox gene Isl1 is required for the correct development of the striatonigral pathway in the mouse. Proceedings of the National Academy of Sciences of the United States of America. 110: E4026-35. PMID 24082127 DOI: 10.1073/pnas.1308275110  1
2013 Nowotschin S, Costello I, Piliszek A, Kwon GS, Mao CA, Klein WH, Robertson EJ, Hadjantonakis AK. The T-box transcription factor Eomesodermin is essential for AVE induction in the mouse embryo. Genes & Development. 27: 997-1002. PMID 23651855 DOI: 10.1101/gad.215152.113  1
2013 Wang J, Sun Z, Zhang Z, Saadi I, Wang J, Li X, Gao S, Engle JJ, Kuburas A, Fu X, Yu W, Klein WH, Russo AF, Amendt BA. Protein inhibitors of activated STAT (Pias1 and Piasy) differentially regulate pituitary homeobox 2 (PITX2) transcriptional activity. The Journal of Biological Chemistry. 288: 12580-95. PMID 23515314 DOI: 10.1074/jbc.M112.374561  1
2013 Mao CA, Cho JH, Wang J, Gao Z, Pan P, Tsai WW, Frishman LJ, Klein WH. Reprogramming amacrine and photoreceptor progenitors into retinal ganglion cells by replacing Neurod1 with Atoh7. Development (Cambridge, England). 140: 541-51. PMID 23293286 DOI: 10.1242/dev.085886  1
2013 Mandal NA, Tran JT, Saadi A, Rahman AK, Huynh TP, Klein WH, Cho JH. Expression and localization of CERKL in the mammalian retina, its response to light-stress, and relationship with NeuroD1 gene. Experimental Eye Research. 106: 24-33. PMID 23142158 DOI: 10.1016/j.exer.2012.10.014  1
2012 Cho JH, Mao CA, Klein WH. Adult mice transplanted with embryonic retinal progenitor cells: new approach for repairing damaged optic nerves. Molecular Vision. 18: 2658-72. PMID 23170059  1
2012 Zou M, Li S, Klein WH, Xiang M. Brn3a/Pou4f1 regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord. Developmental Biology. 364: 114-27. PMID 22326227 DOI: 10.1016/j.ydbio.2012.01.021  1
2011 Agca C, Elhajj MC, Klein WH, Venuti JM. Neurosensory and neuromuscular organization in tube feet of the sea urchin Strongylocentrotus purpuratus. The Journal of Comparative Neurology. 519: 3566-79. PMID 21800307 DOI: 10.1002/cne.22724  1
2011 Meadows E, Flynn JM, Klein WH. Myogenin regulates exercise capacity but is dispensable for skeletal muscle regeneration in adult mdx mice. Plos One. 6: e16184. PMID 21264243 DOI: 10.1371/journal.pone.0016184  1
2011 Mao CA, Tsai WW, Cho JH, Pan P, Barton MC, Klein WH. Neuronal transcriptional repressor REST suppresses an Atoh7-independent program for initiating retinal ganglion cell development. Developmental Biology. 349: 90-9. PMID 20969844 DOI: 10.1016/j.ydbio.2010.10.008  1
2011 Kiyama T, Mao CA, Cho JH, Fu X, Pan P, Mu X, Klein WH. Overlapping spatiotemporal patterns of regulatory gene expression are required for neuronal progenitors to specify retinal ganglion cell fate. Vision Research. 51: 251-9. PMID 20951721 DOI: 10.1016/j.visres.2010.10.016  1
2010 Flynn JM, Meadows E, Fiorotto M, Klein WH. Myogenin regulates exercise capacity and skeletal muscle metabolism in the adult mouse. Plos One. 5: e13535. PMID 21042574 DOI: 10.1371/journal.pone.0013535  1
2010 Moresi V, Williams AH, Meadows E, Flynn JM, Potthoff MJ, McAnally J, Shelton JM, Backs J, Klein WH, Richardson JA, Bassel-Duby R, Olson EN. Myogenin and class II HDACs control neurogenic muscle atrophy by inducing E3 ubiquitin ligases. Cell. 143: 35-45. PMID 20887891 DOI: 10.1016/j.cell.2010.09.004  1
2010 Sessa A, Mao CA, Colasante G, Nini A, Klein WH, Broccoli V. Tbr2-positive intermediate (basal) neuronal progenitors safeguard cerebral cortex expansion by controlling amplification of pallial glutamatergic neurons and attraction of subpallial GABAergic interneurons. Genes & Development. 24: 1816-26. PMID 20713522 DOI: 10.1101/gad.575410  1
2009 Kiyama T, Zhang J, Liang S, Liang S, Klein WH. Intragenomic evolution of a transcriptional enhancer in the genome of Strongylocentrotus purpuratus. Marine Genomics. 2: 85-98. PMID 21798176 DOI: 10.1016/j.margen.2009.03.007  1
2009 Agca C, Klein WH, Venuti JM. Reduced O2 and elevated ROS in sea urchin embryos leads to defects in ectoderm differentiation. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 238: 1777-87. PMID 19517573 DOI: 10.1002/dvdy.22001  1
2009 Fu X, Kiyama T, Li R, Russell M, Klein WH, Mu X. Epitope-tagging Math5 and Pou4f2: new tools to study retinal ganglion cell development in the mouse. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 238: 2309-17. PMID 19459208 DOI: 10.1002/dvdy.21974  1
2009 Agca C, Klein WH, Venuti JM. Respecification of ectoderm and altered Nodal expression in sea urchin embryos after cobalt and nickel treatment. Mechanisms of Development. 126: 430-42. PMID 19368800 DOI: 10.1016/j.mod.2009.01.005  1
2009 Cho JH, Mu X, Wang SW, Klein WH. Retinal ganglion cell death and optic nerve degeneration by genetic ablation in adult mice. Experimental Eye Research. 88: 542-52. PMID 19109949 DOI: 10.1016/j.exer.2008.11.021  1
2009 Tang H, Macpherson P, Marvin M, Meadows E, Klein WH, Yang XJ, Goldman D. A histone deacetylase 4/myogenin positive feedback loop coordinates denervation-dependent gene induction and suppression. Molecular Biology of the Cell. 20: 1120-31. PMID 19109424 DOI: 10.1091/mbc.E08-07-0759  1
2008 Sessa A, Mao CA, Hadjantonakis AK, Klein WH, Broccoli V. Tbr2 directs conversion of radial glia into basal precursors and guides neuronal amplification by indirect neurogenesis in the developing neocortex. Neuron. 60: 56-69. PMID 18940588 DOI: 10.1016/j.neuron.2008.09.028  1
2008 Sapieha P, Sirinyan M, Hamel D, Zaniolo K, Joyal JS, Cho JH, Honoré JC, Kermorvant-Duchemin E, Varma DR, Tremblay S, Leduc M, Rihakova L, Hardy P, Klein WH, Mu X, et al. The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis. Nature Medicine. 14: 1067-76. PMID 18836459 DOI: 10.1038/nm.1873  1
2008 Mao CA, Wang SW, Pan P, Klein WH. Rewiring the retinal ganglion cell gene regulatory network: Neurod1 promotes retinal ganglion cell fate in the absence of Math5. Development (Cambridge, England). 135: 3379-88. PMID 18787067 DOI: 10.1242/dev.024612  1
2008 Meadows E, Cho JH, Flynn JM, Klein WH. Myogenin regulates a distinct genetic program in adult muscle stem cells. Developmental Biology. 322: 406-14. PMID 18721801 DOI: 10.1016/j.ydbio.2008.07.024  1
2008 Mu X, Fu X, Beremand PD, Thomas TL, Klein WH. Gene regulation logic in retinal ganglion cell development: Isl1 defines a critical branch distinct from but overlapping with Pou4f2. Proceedings of the National Academy of Sciences of the United States of America. 105: 6942-7. PMID 18460603 DOI: 10.1073/pnas.0802627105  1
2008 Mao CA, Kiyama T, Pan P, Furuta Y, Hadjantonakis AK, Klein WH. Eomesodermin, a target gene of Pou4f2, is required for retinal ganglion cell and optic nerve development in the mouse. Development (Cambridge, England). 135: 271-80. PMID 18077589 DOI: 10.1242/dev.009688  1
2007 Davie JK, Cho JH, Meadows E, Flynn JM, Knapp JR, Klein WH. Target gene selectivity of the myogenic basic helix-loop-helix transcription factor myogenin in embryonic muscle. Developmental Biology. 311: 650-64. PMID 17904117 DOI: 10.1016/j.ydbio.2007.08.014  1
2007 Kiyama T, Klein WH. SpGataE, a Strongylocentrotus purpuratus ortholog of mammalian Gata4/5/6: protein expression, interaction with putative target gene spec2a, and identification of friend of Gata factor SpFog1. Development Genes and Evolution. 217: 651-63. PMID 17710433 DOI: 10.1007/s00427-007-0174-z  1
2007 Rishniw M, Fisher PW, Doran RM, Meadows E, Klein WH, Kotlikoff MI. Smooth muscle persists in the muscularis externa of developing and adult mouse esophagus. Journal of Muscle Research and Cell Motility. 28: 153-65. PMID 17638088 DOI: 10.1007/s10974-007-9112-y  1
2007 Cho JH, Klein WH, Tsai MJ. Compensational regulation of bHLH transcription factors in the postnatal development of BETA2/NeuroD1-null retina. Mechanisms of Development. 124: 543-50. PMID 17629466 DOI: 10.1016/j.mod.2007.06.001  1
2007 Ai D, Fu X, Wang J, Lu MF, Chen L, Baldini A, Klein WH, Martin JF. Canonical Wnt signaling functions in second heart field to promote right ventricular growth. Proceedings of the National Academy of Sciences of the United States of America. 104: 9319-24. PMID 17519332 DOI: 10.1073/pnas.0701212104  1
2006 Sodergren E, Weinstock GM, Davidson EH, Cameron RA, Gibbs RA, Angerer RC, Angerer LM, Arnone MI, Burgess DR, Burke RD, Coffman JA, Dean M, Elphick MR, Ettensohn CA, ... ... Klein WH, et al. The genome of the sea urchin Strongylocentrotus purpuratus. Science (New York, N.Y.). 314: 941-52. PMID 17095691 DOI: 10.1126/science.1133609  1
2006 Burke RD, Angerer LM, Elphick MR, Humphrey GW, Yaguchi S, Kiyama T, Liang S, Mu X, Agca C, Klein WH, Brandhorst BP, Rowe M, Wilson K, Churcher AM, Taylor JS, et al. A genomic view of the sea urchin nervous system. Developmental Biology. 300: 434-60. PMID 16965768 DOI: 10.1016/j.ydbio.2006.08.007  1
2006 Fu X, Sun H, Klein WH, Mu X. Beta-catenin is essential for lamination but not neurogenesis in mouse retinal development. Developmental Biology. 299: 424-37. PMID 16959241 DOI: 10.1016/j.ydbio.2006.08.015  1
2006 Knapp JR, Davie JK, Myer A, Meadows E, Olson EN, Klein WH. Loss of myogenin in postnatal life leads to normal skeletal muscle but reduced body size. Development (Cambridge, England). 133: 601-10. PMID 16407395 DOI: 10.1242/dev.02249  1
2005 Mu X, Fu X, Sun H, Beremand PD, Thomas TL, Klein WH. A gene network downstream of transcription factor Math5 regulates retinal progenitor cell competence and ganglion cell fate. Developmental Biology. 280: 467-81. PMID 15882586 DOI: 10.1016/j.ydbio.2005.01.028  1
2005 Kiyama T, Zhang N, Dayal S, Yun Lee P, Liang S, Villinski JT, Klein WH. Strongylocentrotus purpuratus transcription factor GATA-E binds to and represses transcription at an Otx-Goosecoid cis-regulatory element within the aboral ectoderm-specific spec2a enhancer. Developmental Biology. 280: 436-47. PMID 15882584 DOI: 10.1016/j.ydbio.2005.01.021  1
2005 Villinski JT, Kiyama T, Dayal S, Zhang N, Liang S, Klein WH. Structure, expression, and transcriptional regulation of the Strongylocentrotus franciscanus spec gene family encoding intracellular calcium-binding proteins. Development Genes and Evolution. 215: 410-22. PMID 15871032 DOI: 10.1007/s00427-005-0489-6  1
2005 Mu X, Fu X, Sun H, Liang S, Maeda H, Frishman LJ, Klein WH. Ganglion cells are required for normal progenitor- cell proliferation but not cell-fate determination or patterning in the developing mouse retina. Current Biology : Cb. 15: 525-30. PMID 15797020 DOI: 10.1016/j.cub.2005.01.043  1
2005 Martin SE, Mu X, Klein WH. Identification of an N-terminal transcriptional activation domain within Brn3b/POU4f2. Differentiation; Research in Biological Diversity. 73: 18-27. PMID 15733064 DOI: 10.1111/j.1432-0436.2005.07301004.x  1
2004 Liang S, Zhao S, Mu X, Thomas T, Klein WH. Novel retinal genes discovered by mining the mouse embryonic RetinalExpress database. Molecular Vision. 10: 773-86. PMID 15496829  1
2004 Dayal S, Kiyama T, Villinski JT, Zhang N, Liang S, Klein WH. Creation of cis-regulatory elements during sea urchin evolution by co-option and optimization of a repetitive sequence adjacent to the spec2a gene. Developmental Biology. 273: 436-53. PMID 15328024 DOI: 10.1016/j.ydbio.2004.06.011  1
2004 Wikramanayake AH, Peterson R, Chen J, Huang L, Bince JM, McClay DR, Klein WH. Nuclear beta-catenin-dependent Wnt8 signaling in vegetal cells of the early sea urchin embryo regulates gastrulation and differentiation of endoderm and mesodermal cell lineages. Genesis (New York, N.Y. : 2000). 39: 194-205. PMID 15282746 DOI: 10.1002/gene.20045  1
2004 Ohtoshi A, Wang SW, Maeda H, Saszik SM, Frishman LJ, Klein WH, Behringer RR. Regulation of retinal cone bipolar cell differentiation and photopic vision by the CVC homeobox gene Vsx1. Current Biology : Cb. 14: 530-6. PMID 15043821 DOI: 10.1016/j.cub.2004.02.027  1
2004 Mu X, Klein WH. A gene regulatory hierarchy for retinal ganglion cell specification and differentiation. Seminars in Cell & Developmental Biology. 15: 115-23. PMID 15036214 DOI: 10.1016/j.semcdb.2003.09.009  1
2004 Mu X, Beremand PD, Zhao S, Pershad R, Sun H, Scarpa A, Liang S, Thomas TL, Klein WH. Discrete gene sets depend on POU domain transcription factor Brn3b/Brn-3.2/POU4f2 for their expression in the mouse embryonic retina. Development (Cambridge, England). 131: 1197-210. PMID 14973295 DOI: 10.1242/dev.01010  1
2004 Klein WH, Mu X. Developmental biology of the retina Seminars in Cell and Developmental Biology. 15: 51. DOI: 10.1016/j.semcdb.2003.09.010  1
2002 Wang SW, Mu X, Bowers WJ, Klein WH. Retinal ganglion cell differentiation in cultured mouse retinal explants. Methods (San Diego, Calif.). 28: 448-56. PMID 12507463 DOI: 10.1016/S1046-2023(02)00264-5  1
2002 Li X, Bhattacharya C, Dayal S, Maity S, Klein WH. Ectoderm gene activation in sea urchin embryos mediated by the CCAAT-binding factor. Differentiation; Research in Biological Diversity. 70: 109-19. PMID 12076338 DOI: 10.1046/j.1432-0436.2002.700206.x  1
2002 Brandhorst BP, Klein WH. Molecular patterning along the sea urchin animal-vegetal axis. International Review of Cytology. 213: 183-232. PMID 11837893 DOI: 10.1016/S0074-7696(02)13015-4  1
2002 Wang SW, Mu X, Bowers WJ, Kim DS, Plas DJ, Crair MC, Federoff HJ, Gan L, Klein WH. Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth. Development (Cambridge, England). 129: 467-77. PMID 11807038  1
2002 Klein WH, Wang SW. Development of the vertebrate retina Methods. 28: 385-386. DOI: 10.1016/S1046-2023(02)00256-6  1
2001 Mu X, Zhao S, Pershad R, Hsieh TF, Scarpa A, Wang SW, White RA, Beremand PD, Thomas TL, Gan L, Klein WH. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Nucleic Acids Research. 29: 4983-93. PMID 11812828  1
2001 Angerer LM, Oleksyn DW, Levine AM, Li X, Klein WH, Angerer RC. Sea urchin goosecoid function links fate specification along the animal-vegetal and oral-aboral embryonic axes. Development (Cambridge, England). 128: 4393-404. PMID 11714666  1
2001 Sumariwalla VM, Klein WH. Similar myogenic functions for myogenin and MRF4 but not MyoD in differentiated murine embryonic stem cells. Genesis (New York, N.Y. : 2000). 30: 239-49. PMID 11536430 DOI: 10.1002/gene.1070  1
2001 Yuh CH, Li X, Davidson EH, Klein WH. Correct Expression of spec2a in the sea urchin embryo requires both Otx and other cis-regulatory elements. Developmental Biology. 232: 424-38. PMID 11401403 DOI: 10.1006/dbio.2001.0207  1
2001 Myer A, Olson EN, Klein WH. MyoD cannot compensate for the absence of myogenin during skeletal muscle differentiation in murine embryonic stem cells. Developmental Biology. 229: 340-50. PMID 11203698 DOI: 10.1006/dbio.2000.9985  1
2001 Wang SW, Kim BS, Ding K, Wang H, Sun D, Johnson RL, Klein WH, Gan L. Requirement for math5 in the development of retinal ganglion cells. Genes & Development. 15: 24-9. PMID 11156601 DOI: 10.1101/gad.855301  1
2000 Wang SW, Gan L, Martin SE, Klein WH. Abnormal polarization and axon outgrowth in retinal ganglion cells lacking the POU-domain transcription factor Brn-3b. Molecular and Cellular Neurosciences. 16: 141-56. PMID 10924257 DOI: 10.1006/mcne.2000.0860  1
2000 Vivian JL, Olson EN, Klein WH. Thoracic skeletal defects in myogenin- and MRF4-deficient mice correlate with early defects in myotome and intercostal musculature. Developmental Biology. 224: 29-41. PMID 10898959 DOI: 10.1006/dbio.2000.9788  1
2000 Valdez MR, Richardson JA, Klein WH, Olson EN. Failure of Myf5 to support myogenic differentiation without myogenin, MyoD, and MRF4. Developmental Biology. 219: 287-98. PMID 10694423 DOI: 10.1006/dbio.2000.9621  1
2000 Huang L, Li X, El-Hodiri HM, Dayal S, Wikramanayake AH, Klein WH. Involvement of Tcf/Lef in establishing cell types along the animal-vegetal axis of sea urchins. Development Genes and Evolution. 210: 73-81. PMID 10664150  1
1999 Wagner DS, Gan L, Klein WH. Identification of a differentially expressed RNA helicase by gene trapping. Biochemical and Biophysical Research Communications. 262: 677-84. PMID 10471385 DOI: 10.1006/bbrc.1999.1208  1
1999 Li X, Wikramanayake AH, Klein WH. Requirement of SpOtx in cell fate decisions in the sea urchin embryo and possible role as a mediator of beta-catenin signaling. Developmental Biology. 212: 425-39. PMID 10433832 DOI: 10.1006/dbio.1999.9360  1
1999 Vivian JL, Klein WH, Hasty P. Temporal, spatial and tissue-specific expression of a myogenin-lacZ transgene targeted to the Hprt locus in mice. Biotechniques. 27: 154-62. PMID 10407678  1
1999 Klein WH, Li X. Function and evolution of Otx proteins. Biochemical and Biophysical Research Communications. 258: 229-33. PMID 10375352 DOI: 10.1006/bbrc.1999.0449  1
1999 Gan L, Wang SW, Huang Z, Klein WH. POU domain factor Brn-3b is essential for retinal ganglion cell differentiation and survival but not for initial cell fate specification. Developmental Biology. 210: 469-80. PMID 10357904 DOI: 10.1006/dbio.1999.9280  1
1999 Vivian JL, Gan L, Olson EN, Klein WH. A hypomorphic myogenin allele reveals distinct myogenin expression levels required for viability, skeletal muscle development, and sternum formation. Developmental Biology. 208: 44-55. PMID 10075840 DOI: 10.1006/dbio.1998.9182  1
1998 Wagner DS, Gan L, Klein WH. Expression of a gene trap reporter construct in a subset of cells in embryonic sites of hematopoiesis: evidence for alternative rRNA production in hematopoietic cells. Biochemical and Biophysical Research Communications. 250: 674-81. PMID 9784405 DOI: 10.1006/bbrc.1998.9309  1
1998 Olson EN, Klein WH. Muscle minus myoD. Developmental Biology. 202: 153-6. PMID 9769168 DOI: 10.1006/dbio.1998.9020  1
1998 Lin X, Gan L, Klein WH, Wells D. Expression and functional analysis of mouse EXT1, a homolog of the human multiple exostoses type 1 gene. Biochemical and Biophysical Research Communications. 248: 738-43. PMID 9703997 DOI: 10.1006/bbrc.1998.9050  1
1998 Wikramanayake AH, Huang L, Klein WH. beta-Catenin is essential for patterning the maternally specified animal-vegetal axis in the sea urchin embryo. Proceedings of the National Academy of Sciences of the United States of America. 95: 9343-8. PMID 9689082 DOI: 10.1073/pnas.95.16.9343  1
1998 Rawls A, Valdez MR, Zhang W, Richardson J, Klein WH, Olson EN. Overlapping functions of the myogenic bHLH genes MRF4 and MyoD revealed in double mutant mice. Development (Cambridge, England). 125: 2349-58. PMID 9609818  1
1997 Xiang M, Gan L, Li D, Zhou L, Chen ZY, Wagner D, O'Malley BW, Klein W, Nathans J. Role of the Brn-3 family of POU-domain genes in the development of the auditory/vestibular, somatosensory, and visual systems. Cold Spring Harbor Symposia On Quantitative Biology. 62: 325-36. PMID 9598366  1
1997 Xiang M, Gan L, Li D, Chen ZY, Zhou L, O'Malley BW, Klein W, Nathans J. Essential role of POU-domain factor Brn-3c in auditory and vestibular hair cell development. Proceedings of the National Academy of Sciences of the United States of America. 94: 9445-50. PMID 9256502 DOI: 10.1073/pnas.94.17.9445  1
1997 Li X, Chuang CK, Mao CA, Angerer LM, Klein WH. Two Otx proteins generated from multiple transcripts of a single gene in Strongylocentrotus purpuratus. Developmental Biology. 187: 253-66. PMID 9242422 DOI: 10.1006/dbio.1997.8610  1
1997 Myer A, Wagner DS, Vivian JL, Olson EN, Klein WH. Wild-type myoblasts rescue the ability of myogenin-null myoblasts to fuse in vivo. Developmental Biology. 185: 127-38. PMID 9187078 DOI: 10.1006/dbio.1997.8565  1
1997 Wikramanayake AH, Klein WH. Multiple signaling events specify ectoderm and pattern the oral-aboral axis in the sea urchin embryo. Development (Cambridge, England). 124: 13-20. PMID 9006063  1
1997 Klein WH, Mao CA, Gan L, Chuang CK, Wikramanayake AH. Manipulating cell fates in the sea urchin embryo Invertebrate Reproduction and Development. 31: 21-29.  1
1996 Wang W, Wikramanayake AH, Gonzalez-Rimbau M, Vlahou A, Flytzanis CN, Klein WH. Very early and transient vegetal-plate expression of SpKrox1, a Krüppel/Krox gene from Stronglyocentrotus purpuratus. Mechanisms of Development. 60: 185-95. PMID 9025071 DOI: 10.1016/S0925-4773(96)00614-4  1
1996 Chuang CK, Wikramanayake AH, Mao CA, Li X, Klein WH. Transient appearance of Strongylocentrotus purpuratus Otx in micromere nuclei: cytoplasmic retention of SpOtx possibly mediated through an alpha-actinin interaction. Developmental Genetics. 19: 231-7. PMID 8952065 DOI: 10.1002/(SICI)1520-6408(1996)19:3<231::AID-DVG6>3.0.CO;2-A  1
1996 Xiang M, Gan L, Zhou L, Klein WH, Nathans J. Targeted deletion of the mouse POU domain gene Brn-3a causes selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling. Proceedings of the National Academy of Sciences of the United States of America. 93: 11950-5. PMID 8876243 DOI: 10.1073/pnas.93.21.11950  1
1996 Brennan TJ, Olson EN, Klein WH, Winslow JW. Extensive motor neuron survival in the absence of secondary skeletal muscle fiber formation. Journal of Neuroscience Research. 45: 57-68. PMID 8811512 DOI: 10.1002/(SICI)1097-4547(19960701)45:1<57::AID-JNR5>3.0.CO;2-G  1
1996 Wang W, Klein WH. A G/C-rich DNA-regulatory element controls positive expression of the sea urchin Lytechinus pictus aboral ectoderm-specific LpS1 gene. Dna and Cell Biology. 15: 133-45. PMID 8634141  1
1996 Gan L, Xiang M, Zhou L, Wagner DS, Klein WH, Nathans J. POU domain factor Brn-3b is required for the development of a large set of retinal ganglion cells. Proceedings of the National Academy of Sciences of the United States of America. 93: 3920-5. PMID 8632990 DOI: 10.1073/pnas.93.9.3920  1
1996 Mao CA, Wikramanayake AH, Gan L, Chuang CK, Summers RG, Klein WH. Altering cell fates in sea urchin embryos by overexpressing SpOtx, an orthodenticle-related protein. Development (Cambridge, England). 122: 1489-98. PMID 8625836  1
1995 Gan L, Mao CA, Wikramanayake A, Angerer LM, Angerer RC, Klein WH. An orthodenticle-related protein from Strongylocentrotus purpuratus. Developmental Biology. 167: 517-28. PMID 7875376 DOI: 10.1006/dbio.1995.1046  1
1995 Cheng TC, Tseng BS, Merlie JP, Klein WH, Olson EN. Activation of the myogenin promoter during mouse embryogenesis in the absence of positive autoregulation. Proceedings of the National Academy of Sciences of the United States of America. 92: 561-5. PMID 7831329 DOI: 10.1073/pnas.92.2.561  1
1995 Wikramanayake AH, Brandhorst BP, Klein WH. Autonomous and non-autonomous differentiation of ectoderm in different sea urchin species. Development (Cambridge, England). 121: 1497-505. PMID 7789279  1
1995 Rawls A, Morris JH, Rudnicki M, Braun T, Arnold HH, Klein WH, Olson EN. Myogenin's functions do not overlap with those of MyoD or Myf-5 during mouse embryogenesis. Developmental Biology. 172: 37-50. PMID 7589813 DOI: 10.1006/dbio.1995.0004  1
1995 Venuti JM, Morris JH, Vivian JL, Olson EN, Klein WH. Myogenin is required for late but not early aspects of myogenesis during mouse development. The Journal of Cell Biology. 128: 563-76. PMID 7532173 DOI: 10.1083/jcb.128.4.563  1
1994 Olson EN, Klein WH. bHLH factors in muscle development: dead lines and commitments, what to leave in and what to leave out. Genes & Development. 8: 1-8. PMID 8288123  1
1994 Mao CA, Gan L, Klein WH. Multiple Otx binding sites required for expression of the Strongylocentrotus purpuratus Spec2a gene. Developmental Biology. 165: 229-42. PMID 8088441 DOI: 10.1006/dbio.1994.1249  1
1993 Hasty P, Bradley A, Morris JH, Edmondson DG, Venuti JM, Olson EN, Klein WH. Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene. Nature. 364: 501-6. PMID 8393145 DOI: 10.1038/364501a0  1
1993 Venuti JM, Gan L, Kozlowski MT, Klein WH. Developmental potential of muscle cell progenitors and the myogenic factor SUM-1 in the sea urchin embryo. Mechanisms of Development. 41: 3-14. PMID 8389581 DOI: 10.1016/0925-4773(93)90051-X  1
1993 Gan L, Klein WH. A positive cis-regulatory element with a bicoid target site lies within the sea urchin Spec2a enhancer. Developmental Biology. 157: 119-32. PMID 8097732 DOI: 10.1006/dbio.1993.1117  1
1992 Sirito M, Walker S, Lin Q, Kozlowski MT, Klein WH, Sawadogo M. Members of the USF family of helix-loop-helix proteins bind DNA as homo- as well as heterodimers. Gene Expression. 2: 231-40. PMID 1450663  1
1991 Venuti JM, Goldberg L, Chakraborty T, Olson EN, Klein WH. A myogenic factor from sea urchin embryos capable of programming muscle differentiation in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 88: 6219-23. PMID 2068103  1
1991 Xiang MQ, Ge T, Tomlinson CR, Klein WH. Structure and promoter activity of the LpS1 genes of Lytechinus pictus. Duplicated exons account for LpS1 proteins with eight calcium binding domains. The Journal of Biological Chemistry. 266: 10524-33. PMID 2037596  1
1991 Pevny L, Simon MC, Robertson E, Klein WH, Tsai SF, D'Agati V, Orkin SH, Costantini F. Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature. 349: 257-60. PMID 1987478 DOI: 10.1038/349257a0  1
1991 Xiang M, Lu SY, Musso M, Karsenty G, Klein WH. A G-string positive cis-regulatory element in the LpS1 promoter binds two distinct nuclear factors distributed non-uniformly in Lytechinus pictus embryos. Development (Cambridge, England). 113: 1345-55. PMID 1811948  1
1991 Kozlowski MT, Gan L, Venuti JM, Sawadogo M, Klein WH. Sea urchin USF: a helix-loop-helix protein active in embryonic ectoderm cells. Developmental Biology. 148: 625-30. PMID 1743406 DOI: 10.1016/0012-1606(91)90280-G  1
1990 Eldon ED, Montpetit IC, Nguyen T, Decker G, Valdizan MC, Klein WH, Brandhorst BP. Localization of the sea urchin Spec3 protein to cilia and Golgi complexes of embryonic ectoderm cells. Genes & Development. 4: 111-22. PMID 2407617  1
1990 Gan L, Zhang W, Klein WH. Repetitive DNA sequences linked to the sea urchin spec genes contain transcriptional enhancer-like elements. Developmental Biology. 139: 186-96. PMID 2328835 DOI: 10.1016/0012-1606(90)90287-S  1
1990 Tomlinson CR, Klein WH. Temporal and spatial transcriptional regulation of the aboral ectoderm-specific Spec genes during sea urchin embryogenesis. Molecular Reproduction and Development. 25: 328-38. PMID 2328125 DOI: 10.1002/mrd.1080250404  1
1990 Tomlinson CR, Kozlowski MT, Klein WH. Ectoderm nuclei from sea urchin embryos contain a Spec-DNA binding protein similar to the vertebrate transcription factor USF. Development (Cambridge, England). 110: 259-72. PMID 2081463  1
1990 Gan L, Wessel GM, Klein WH. Regulatory elements from the related spec genes of Strongylocentrotus purpuratus yield different spatial patterns with a lacZ reporter gene. Developmental Biology. 142: 346-59. PMID 1701736 DOI: 10.1016/0012-1606(90)90355-M  1
1990 Wessel GM, Zhang W, Klein WH. Myosin heavy chain accumulates in dissimilar cell types of the macromere lineage in the sea urchin embryo. Developmental Biology. 140: 447-54. PMID 1695586 DOI: 10.1016/0012-1606(90)90093-X  1
1989 Wessel GM, Zhang W, Tomlinson CR, Lennarz WJ, Klein WH. Transcription of the Spec 1-like gene of Lytechinus is selectively inhibited in response to disruption of the extracellular matrix. Development (Cambridge, England). 106: 355-65. PMID 2591320  1
1989 Wessel GM, Goldberg L, Lennarz WJ, Klein WH. Gastrulation in the sea urchin is accompanied by the accumulation of an endoderm-specific mRNA. Developmental Biology. 136: 526-36. PMID 2583374 DOI: 10.1016/0012-1606(89)90278-9  1
1988 Xiang MQ, Bédard PA, Wessel G, Filion M, Brandhorst BP, Klein WH. Tandem duplication and divergence of a sea urchin protein belonging to the troponin C superfamily. The Journal of Biological Chemistry. 263: 17173-80. PMID 3182842  1
1988 Hardin PE, Angerer LM, Hardin SH, Angerer RC, Klein WH. Spec2 genes of Strongylocentrotus purpuratus. Structure and differential expression in embryonic aboral ectoderm cells. Journal of Molecular Biology. 202: 417-31. PMID 3172223 DOI: 10.1016/0022-2836(88)90275-6  1
1987 Hardin SH, Keast MJ, Hardin PE, Klein WH. Use of consensus oligonucleotides for detecting and isolating nucleic acids encoding calcium binding domains of the troponin C superfamily. Biochemistry. 26: 3518-23. PMID 3651394  1
1987 Hardin PE, Klein WH. Unusual sequence conservation in the 5' and 3' untranslated regions of the sea urchin spec mRNAs. Journal of Molecular Evolution. 25: 126-33. PMID 3116272 DOI: 10.1007/BF02101754  1
1987 Eldon ED, Angerer LM, Angerer RC, Klein WH. Spec3: embryonic expression of a sea urchin gene whose product is involved in ectodermal ciliogenesis. Genes & Development. 1: 1280-92. PMID 2828169  1
1987 Klein WH, Hardin SH, Brandhorst BP. [29]Spec proteins: Calcium-binding proteins in the embryonic ectoderm cells of sea urchins Methods in Enzymology. 139: 354-363. DOI: 10.1016/0076-6879(87)39098-6  1
1986 Floyd EE, Gong ZY, Brandhorst BP, Klein WH. Calmodulin gene expression during sea urchin development: persistence of a prevalent maternal protein. Developmental Biology. 113: 501-11. PMID 3753945 DOI: 10.1016/0012-1606(86)90185-5  1
1985 Hardin SH, Carpenter CD, Hardin PE, Bruskin AM, Klein WH. Structure of the Spec1 gene encoding a major calcium-binding protein in the embryonic ectoderm of the sea urchin, Strongylocentrotus purpuratus. Journal of Molecular Biology. 186: 243-55. PMID 2935638 DOI: 10.1016/0022-2836(85)90101-9  1
1984 Carpenter CD, Bruskin AM, Hardin PE, Keast MJ, Anstrom J, Tyner AL, Brandhorst BP, Klein WH. Novel proteins belonging to the troponin C superfamily are encoded by a set of mRNAs in sea urchin embryos. Cell. 36: 663-71. PMID 6697391 DOI: 10.1016/0092-8674(84)90346-5  1
1983 Forney JD, Epstein LM, Preer LB, Rudman BM, Widmayer DJ, Klein WH, Preer JR. Structure and expression of genes for surface proteins in Paramecium. Molecular and Cellular Biology. 3: 466-74. PMID 6188948  1
1982 Carpenter CD, Bruskin AM, Spain LM, Eldon ED, Klein WH. The 3' untranslated regions of two related mRNAs contain an element highly repeated in the sea urchin genome. Nucleic Acids Research. 10: 7829-42. PMID 6296792 DOI: 10.1093/nar/10.23.7829  1
1981 Wells DE, Showman RM, Klein WH, Raff RA. Delayed recruitment of maternal histone H3 mRNA in sea urchin embryos. Nature. 292: 477-8. PMID 7254343 DOI: 10.1038/292477a0  1
1981 Bruskin AM, Tyner AL, Wells DE, Showman RM, Klein WH. Accumulation in embryogenesis of five mRNAs enriched in the ectoderm of the sea urchin pluteus. Developmental Biology. 87: 308-18. PMID 6169573 DOI: 10.1016/0012-1606(81)90154-8  1
1978 Wold BJ, Klein WH, Hough-Evans BR, Britten RJ, Davidson EH. Sea urchin embryo mRNA sequences expressed in the nuclear RNA of adult tissues. Cell. 14: 941-50. PMID 688400 DOI: 10.1016/0092-8674(78)90348-3  1
1978 Klein WH, Thomas TL, Lai C, Scheller RH, Britten RJ, Davidson EH. Characteristics of individual repetitive sequence families in the sea urchin genome studied with cloned repeats. Cell. 14: 889-900. PMID 688398  0.92
1977 Galau GA, Klein WH, Britten RJ, Davidson EH. Significance of rare m RNA sequences in liver. Archives of Biochemistry and Biophysics. 179: 584-99. PMID 851359  0.92
1977 Scheller RH, Thomas TL, Lee AS, Klein WH, Niles WD, Britten RJ, Davidson EH. Clones of individual repetitive sequences from sea urchin DNA constructed with synthetic Eco RI sites. Science (New York, N.Y.). 196: 197-200. PMID 847467  1
1977 Davidson EH, Klein WH, Britten RJ. Sequence organization in animal DNA and a speculation on hnRNA as a coordinate regulatory transcript. Developmental Biology. 55: 69-84. PMID 832773  0.92
1976 Galau GA, Klein WH, Davis MM, Wold BJ, Britten RJ, Davidson EH. Structural gene sets active in embryos and adult tissues of the sea urchin. Cell. 7: 487-505. PMID 986248 DOI: 10.1016/0092-8674(76)90200-2  1
1975 Davidson EH, Hough BR, Klein WH, Britten RJ. Structural genes adjacent to interspersed repetitive DNA sequences. Cell. 4: 217-38. PMID 1122554  0.92
1974 Klein WH, Murphy W, Attardi G, Britten RJ, Davidson EH. Distribution of repetitive and nonrepetivite sequence transcripts in HeLa mRNA. Proceedings of the National Academy of Sciences of the United States of America. 71: 1785-9. PMID 4525461  0.92
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