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Josephine Lai - Publications

Affiliations: 
University of Arizona, Tucson, AZ 
Area:
Pain
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169 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Lee YS, Remesic M, Ramos-Colon C, Hall SM, Kuzmin A, Rankin D, Porreca F, Lai J, Hruby VJ. Cyclic non-opioid dynorphin A analogues for the bradykinin receptors. Bioorganic & Medicinal Chemistry Letters. PMID 27756562 DOI: 10.1016/J.Bmcl.2016.10.010  0.563
2016 Hall SM, LeBaron L, Ramos-Colon CN, Qu C, Xie JY, Porreca F, Lai J, Lee YS, Hruby VJ. Discovery of Stable Non-opioid Dynorphin A Analogues Interacting at the Bradykinin Receptors for the Treatment of Neuropathic Pain. Acs Chemical Neuroscience. PMID 27619237 DOI: 10.1021/Acschemneuro.6B00258  0.558
2016 Lee YS, Kupp R, Remesic M, Ramos-Colon C, Hall SM, Chan C, Rankin D, Lai J, Porreca F, Hruby VJ. Various modifications of the amphipathic dynorphin A phamacophore for rat brain bradykinin receptors. Chemical Biology & Drug Design. PMID 27203574 DOI: 10.1111/Cbdd.12789  0.509
2015 Deekonda S, Rankin D, Davis P, Lai J, Vanderah TW, Porecca F, Hruby VJ. Design synthesis and structure-activity relationship of 5-substituted (tetrahydronaphthalen-2yl)methyl with N-phenyl-N-(piperidin-2-yl)propionamide derivatives as opioid ligands. Bioorganic & Medicinal Chemistry. PMID 26712115 DOI: 10.1016/J.Bmc.2015.11.030  0.661
2015 Deekonda S, Cole J, Sunna S, Rankin D, Largent-Milnes TM, Davis P, BassiriRad NM, Lai J, Vanderah TW, Porecca F, Hruby VJ. Enkephalin analogues with N-phenyl-N-(piperidin-2-ylmethyl)propionamide derivatives: Synthesis and biological evaluations. Bioorganic & Medicinal Chemistry Letters. PMID 26611918 DOI: 10.1016/J.Bmcl.2015.10.081  0.664
2015 Deekonda S, Wugalter L, Rankin D, Largent-Milnes TM, Davis P, Wang Y, Bassirirad NM, Lai J, Kulkarni V, Vanderah TW, Porreca F, Hruby VJ. Design and synthesis of novel bivalent ligands (MOR and DOR) by conjugation of enkephalin analogues with 4-anilidopiperidine derivatives. Bioorganic & Medicinal Chemistry Letters. PMID 26323872 DOI: 10.1016/J.Bmcl.2015.07.064  0.683
2015 Deekonda S, Rankin D, Davis P, Lai J, Porreca F, Hruby VJ. Design, synthesis and biological evaluation of multifunctional ligands targeting opioid and bradykinin 2 receptors. Bioorganic & Medicinal Chemistry Letters. 25: 4148-52. PMID 26316468 DOI: 10.1016/J.Bmcl.2015.08.014  0.521
2015 Deekonda S, Wugalter L, Kulkarni V, Rankin D, Largent-Milnes TM, Davis P, Bassirirad NM, Lai J, Vanderah TW, Porreca F, Hruby VJ. Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands. Bioorganic & Medicinal Chemistry. 23: 6185-94. PMID 26299827 DOI: 10.1016/J.Bmc.2015.07.071  0.687
2015 Lee YS, Hall SM, Ramos-Colon C, Remesic M, Rankin D, Vanderah TW, Porreca F, Lai J, Hruby VJ. Blockade of non-opioid excitatory effects of spinal dynorphin A at bradykinin receptors. Receptors & Clinical Investigation. 2. PMID 26221618 DOI: 10.14800/Rci.517  0.751
2015 Nair P, Yamamoto T, Cowell S, Kulkarni V, Moye S, Navratilova E, Davis P, Ma SW, Vanderah TW, Lai J, Porreca F, Hruby VJ. Discovery of tripeptide-derived multifunctional ligands possessing delta/mu opioid receptor agonist and neurokinin 1 receptor antagonist activities. Bioorganic & Medicinal Chemistry Letters. 25: 3716-20. PMID 26212775 DOI: 10.1016/J.Bmcl.2015.06.030  0.791
2015 Mehr-un-Nisa, Munawar MA, Lee YS, Rankin D, Munir J, Lai J, Khan MA, Hruby VJ. Design, synthesis, and biological evaluation of a series of bifunctional ligands of opioids/SSRIs. Bioorganic & Medicinal Chemistry. 23: 1251-9. PMID 25703306 DOI: 10.1016/J.Bmc.2015.01.047  0.558
2015 Guillemyn K, Kleczkowska P, Lesniak A, Dyniewicz J, Van der Poorten O, Van den Eynde I, Keresztes A, Varga E, Lai J, Porreca F, Chung NN, Lemieux C, Mika J, Rojewska E, Makuch W, et al. Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist - neurokinin-1 antagonist peptidomimetics. European Journal of Medicinal Chemistry. 92: 64-77. PMID 25544687 DOI: 10.1016/j.ejmech.2014.12.033  0.572
2015 Lee YS, Hall SM, Ramos-Colon C, Remesic M, LeBaron L, Nguyen A, Rankin D, Porreca F, Lai J, Hruby VJ. Modification of amphipathic non-opioid dynorphin A analogues for rat brain bradykinin receptors. Bioorganic & Medicinal Chemistry Letters. 25: 30-3. PMID 25434001 DOI: 10.1016/J.Bmcl.2014.11.026  0.5
2015 Deekonda S, Rankin D, Davis P, Lai J, Porreca F, Hruby VJ. Design, synthesis and biological evaluation of multifunctional ligands targeting opioid and bradykinin 2 receptors Bioorganic and Medicinal Chemistry Letters. DOI: 10.1016/j.bmcl.2015.08.014  0.379
2015 Deekonda S, Wugalter L, Kulkarni V, Rankin D, Largent-Milnes TM, Davis P, Bassirirad NM, Lai J, Vanderah TW, Porreca F, Hruby VJ. Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands Bioorganic and Medicinal Chemistry. 23: 6185-6194. DOI: 10.1016/j.bmc.2015.07.071  0.592
2014 Lee YS, Rankin D, Hall SM, Ramos-Colon C, Ortiz JJ, Kupp R, Porreca F, Lai J, Hruby VJ. Structure-activity relationships of non-opioid [des-Arg(7)]-dynorphin A analogues for bradykinin receptors. Bioorganic & Medicinal Chemistry Letters. 24: 4976-9. PMID 25282551 DOI: 10.1016/J.Bmcl.2014.09.033  0.489
2014 Bannister K, Lee YS, Goncalves L, Porreca F, Lai J, Dickenson AH. Neuropathic plasticity in the opioid and non-opioid actions of dynorphin A fragments and their interactions with bradykinin B2 receptors on neuronal activity in the rat spinal cord. Neuropharmacology. 85: 375-83. PMID 24937046 DOI: 10.1016/J.Neuropharm.2014.06.005  0.636
2014 Lee YS, Muthu D, Hall SM, Ramos-Colon C, Rankin D, Hu J, Sandweiss AJ, De Felice M, Xie JY, Vanderah TW, Porreca F, Lai J, Hruby VJ. Discovery of amphipathic dynorphin A analogues to inhibit the neuroexcitatory effects of dynorphin A through bradykinin receptors in the spinal cord. Journal of the American Chemical Society. 136: 6608-16. PMID 24742335 DOI: 10.1021/Ja501677Q  0.671
2013 Lee YS, Qu HC, Davis P, Ma SW, Vardanyan R, Lai J, Porreca F, Hruby VJ. Chiral Effect of a Phe Residue in Position 3 of the Dmt(1)-L(or D)-Tic(2) Analogues on Opioid Functional Activities. Acs Medicinal Chemistry Letters. 4: 656-659. PMID 24648867 DOI: 10.1021/Ml400115N  0.513
2013 Nair P, Yamamoto T, Largent-Milnes TM, Cowell S, Kulkarni V, Moye S, Navratilova E, Davis P, Ma SW, Vanderah TW, Lai J, Porreca F, Hruby VJ. Truncation of the peptide sequence in bifunctional ligands with mu and delta opioid receptor agonist and neurokinin 1 receptor antagonist activities. Bioorganic & Medicinal Chemistry Letters. 23: 4975-8. PMID 23899615 DOI: 10.1016/J.Bmcl.2013.06.065  0.787
2013 Petrov RR, Lee YS, Vardanyan RS, Liu L, Ma SW, Davis P, Lai J, Porreca F, Vanderah TW, Hruby VJ. Effect of anchoring 4-anilidopiperidines to opioid peptides. Bioorganic & Medicinal Chemistry Letters. 23: 3434-7. PMID 23623418 DOI: 10.1016/J.Bmcl.2013.03.065  0.662
2013 Mollica A, Pinnen F, Costante R, Locatelli M, Stefanucci A, Pieretti S, Davis P, Lai J, Rankin D, Porreca F, Hruby VJ. Biological active analogues of the opioid peptide biphalin: mixed α/β(3)-peptides. Journal of Medicinal Chemistry. 56: 3419-23. PMID 23547584 DOI: 10.1021/Jm301456C  0.461
2012 Mollica A, Pinnen F, Stefanucci A, Mannina L, Sobolev AP, Lucente G, Davis P, Lai J, Ma SW, Porreca F, Hruby VJ. cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues: part 2. Journal of Medicinal Chemistry. 55: 8477-82. PMID 22966938 DOI: 10.1021/jm300947s  0.31
2012 Mollica A, Pinnen F, Stefanucci A, Feliciani F, Campestre C, Mannina L, Sobolev AP, Lucente G, Davis P, Lai J, Ma SW, Porreca F, Hruby VJ. The cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues. Journal of Medicinal Chemistry. 55: 3027-35. PMID 22394120 DOI: 10.1021/Jm201402V  0.439
2012 Marshall TM, Herman DS, Largent-Milnes TM, Badghisi H, Zuber K, Holt SC, Lai J, Porreca F, Vanderah TW. Activation of descending pain-facilitatory pathways from the rostral ventromedial medulla by cholecystokinin elicits release of prostaglandin-Eâ‚‚ in the spinal cord. Pain. 153: 86-94. PMID 22030324 DOI: 10.1016/J.Pain.2011.09.021  0.626
2011 Vardanyan R, Kumirov VK, Nichol GS, Davis P, Liktor-Busa E, Rankin D, Varga E, Vanderah T, Porreca F, Lai J, Hruby VJ. Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands. Bioorganic & Medicinal Chemistry. 19: 6135-42. PMID 21925887 DOI: 10.1016/J.Bmc.2011.08.027  0.639
2011 De Felice M, Sanoja R, Wang R, Vera-Portocarrero L, Oyarzo J, King T, Ossipov MH, Vanderah TW, Lai J, Dussor GO, Fields HL, Price TJ, Porreca F. Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain. Pain. 152: 2701-9. PMID 21745713 DOI: 10.1016/J.Pain.2011.06.008  0.652
2011 King T, Qu C, Okun A, Mercado R, Ren J, Brion T, Lai J, Porreca F. Contribution of afferent pathways to nerve injury-induced spontaneous pain and evoked hypersensitivity. Pain. 152: 1997-2005. PMID 21620567 DOI: 10.1016/J.Pain.2011.04.020  0.442
2011 Hanlon KE, Herman DS, Agnes RS, Largent-Milnes TM, Kumarasinghe IR, Ma SW, Guo W, Lee YS, Ossipov MH, Hruby VJ, Lai J, Porreca F, Vanderah TW. Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain. Brain Research. 1395: 1-11. PMID 21550594 DOI: 10.1016/J.Brainres.2011.04.024  0.716
2011 Qu C, King T, Okun A, Lai J, Fields HL, Porreca F. Lesion of the rostral anterior cingulate cortex eliminates the aversiveness of spontaneous neuropathic pain following partial or complete axotomy. Pain. 152: 1641-8. PMID 21474245 DOI: 10.1016/J.Pain.2011.03.002  0.418
2011 Ballet S, Feytens D, Buysse K, Chung NN, Lemieux C, Tumati S, Keresztes A, Van Duppen J, Lai J, Varga E, Porreca F, Schiller PW, Vanden Broeck J, Tourwé D. Design of novel neurokinin 1 receptor antagonists based on conformationally constrained aromatic amino acids and discovery of a potent chimeric opioid agonist-neurokinin 1 receptor antagonist. Journal of Medicinal Chemistry. 54: 2467-76. PMID 21413804 DOI: 10.1021/jm1016285  0.55
2011 Yamamoto T, Nair P, Largent-Milnes TM, Jacobsen NE, Davis P, Ma SW, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies. Journal of Medicinal Chemistry. 54: 2029-38. PMID 21366266 DOI: 10.1021/Jm101023R  0.739
2011 Vera-Portocarrero LP, Ossipov MH, Lai J, King T, Porreca F. Descending facilitatory pathways from the rostroventromedial medulla mediate naloxone-precipitated withdrawal in morphine-dependent rats. The Journal of Pain : Official Journal of the American Pain Society. 12: 667-76. PMID 21354865 DOI: 10.1016/J.Jpain.2010.12.007  0.57
2011 Lee YS, Kulkarani V, Cowell SM, Ma SW, Davis P, Hanlon KE, Vanderah TW, Lai J, Porreca F, Vardanyan R, Hruby VJ. Development of potent μ and δ opioid agonists with high lipophilicity. Journal of Medicinal Chemistry. 54: 382-6. PMID 21128594 DOI: 10.1021/Jm100982D  0.688
2011 Mollica A, Pinnen F, Feliciani F, Stefanucci A, Lucente G, Davis P, Porreca F, Ma SW, Lai J, Hruby VJ. New potent biphalin analogues containing p-fluoro-L-phenylalanine at the 4,4' positions and non-hydrazine linkers. Amino Acids. 40: 1503-11. PMID 20924622 DOI: 10.1007/S00726-010-0760-7  0.314
2011 Ballet S, Frankiewicz L, Guillemyn K, van den Eynde I, Chung NN, Keresztes A, Van Duppen J, Lai J, Varga E, Porreca F, Schiller PW, Vanden Broeck J, Tourwé D. Evaluation of constrained amino acids in the design of neurokinin 1 receptor- and bifunctional opioid – neurokinin 1 receptor ligands Pharmacological Reports. 63: 229. DOI: 10.1016/S1734-1140(11)70448-0  0.49
2010 Largent-Milnes TM, Yamamoto T, Nair P, Moulton JW, Hruby VJ, Lai J, Porreca F, Vanderah TW. Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance. British Journal of Pharmacology. 161: 986-1001. PMID 20977451 DOI: 10.1111/J.1476-5381.2010.00824.X  0.733
2010 Giordano C, Sansone A, Masi A, Lucente G, Punzi P, Mollica A, Pinnen F, Feliciani F, Cacciatore I, Davis P, Lai J, Ma SW, Porreca F, Hruby V. Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2. European Journal of Medicinal Chemistry. 45: 4594-600. PMID 20692738 DOI: 10.1016/J.Ejmech.2010.07.022  0.51
2010 Yamamoto T, Nair P, Jacobsen NE, Kulkarni V, Davis P, Ma SW, Navratilova E, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillamines. Journal of Medicinal Chemistry. 53: 5491-501. PMID 20617791 DOI: 10.1021/Jm100157M  0.834
2010 Vardanyan M, Melemedjian OK, Price TJ, Ossipov MH, Lai J, Roberts E, Boos TL, Deschamps JR, Jacobson AE, Rice KC, Porreca F. Reversal of pancreatitis-induced pain by an orally available, small molecule interleukin-6 receptor antagonist. Pain. 151: 257-65. PMID 20599324 DOI: 10.1016/J.Pain.2010.05.022  0.724
2010 Lee YS, Fernandes S, Kulkarani V, Mayorov A, Davis P, Ma SW, Brown K, Gillies RJ, Lai J, Porreca F, Hruby VJ. Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of pain. Bioorganic & Medicinal Chemistry Letters. 20: 4080-4. PMID 20547453 DOI: 10.1016/J.Bmcl.2010.05.078  0.549
2010 Chen Q, Vera-Portocarrero LP, Ossipov MH, Vardanyan M, Lai J, Porreca F. Attenuation of persistent experimental pancreatitis pain by a bradykinin b2 receptor antagonist. Pancreas. 39: 1220-5. PMID 20531238 DOI: 10.1097/Mpa.0B013E3181Df1C90  0.458
2010 Torino D, Mollica A, Pinnen F, Feliciani F, Lucente G, Fabrizi G, Portalone G, Davis P, Lai J, Ma SW, Porreca F, Hruby VJ. Synthesis and evaluation of new endomorphin-2 analogues containing (Z)-alpha,beta-didehydrophenylalanine (Delta(Z)Phe) residues. Journal of Medicinal Chemistry. 53: 4550-4. PMID 20476738 DOI: 10.1021/Jm1001343  0.45
2010 De Felice M, Ossipov MH, Wang R, Lai J, Chichorro J, Meng I, Dodick DW, Vanderah TW, Dussor G, Porreca F. Triptan-induced latent sensitization: a possible basis for medication overuse headache. Annals of Neurology. 67: 325-37. PMID 20373344 DOI: 10.1002/Ana.21897  0.559
2010 King T, Vera-Portocarrero L, Gutierrez T, Vanderah TW, Dussor G, Lai J, Fields HL, Porreca F. Erratum: Corrigendum: Unmasking the tonic-aversive state in neuropathic pain Nature Neuroscience. 13: 1033-1033. DOI: 10.1038/Nn0810-1033B  0.586
2009 Yamamoto T, Nair P, Jacobsen NE, Vagner J, Kulkarni V, Davis P, Ma SW, Navratilova E, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists. Journal of Medicinal Chemistry. 52: 5164-75. PMID 20560643 DOI: 10.1021/Jm900473P  0.794
2009 King T, Vera-Portocarrero L, Gutierrez T, Vanderah TW, Dussor G, Lai J, Fields HL, Porreca F. Unmasking the tonic-aversive state in neuropathic pain. Nature Neuroscience. 12: 1364-6. PMID 19783992 DOI: 10.1038/Nn.2407  0.594
2009 Yamamoto T, Nair P, Ma SW, Davis P, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety. Bioorganic & Medicinal Chemistry. 17: 7337-43. PMID 19762245 DOI: 10.1016/J.Bmc.2009.08.035  0.746
2009 Torino D, Mollica A, Pinnen F, Lucente G, Feliciani F, Davis P, Lai J, Ma SW, Porreca F, Hruby VJ. Synthesis and evaluation of new endomorphin analogues modified at the Pro(2) residue. Bioorganic & Medicinal Chemistry Letters. 19: 4115-8. PMID 19560919 DOI: 10.1016/J.Bmcl.2009.06.008  0.361
2009 Vardanyan R, Vijay G, Nichol GS, Liu L, Kumarasinghe I, Davis P, Vanderah T, Porreca F, Lai J, Hruby VJ. Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain. Bioorganic & Medicinal Chemistry. 17: 5044-53. PMID 19540763 DOI: 10.1016/J.Bmc.2009.05.065  0.697
2009 Nair P, Yamamoto T, Kulkarni V, Moye S, Navratilova E, Davis P, Largent T, Ma SW, Yamamura HI, Vanderah T, Lai J, Porreca F, Hruby VJ. Novel bifunctional peptides as opioid agonists and NK-1 antagonists. Advances in Experimental Medicine and Biology. 611: 537-8. PMID 19400302 DOI: 10.1007/978-0-387-73657-0_235  0.834
2009 Lee Y, Petrov R, Kulkarni V, Min BJ, Ma SW, Davis P, Oyarzo J, Vanderah T, Lai J, Porreca F, Vardanyan R, Hruby VJ. Development of mu/delta opioid ligands: enkephalin analogues containing 4-anilidopiperidine moiety. Advances in Experimental Medicine and Biology. 611: 517-8. PMID 19400292 DOI: 10.1007/978-0-387-73657-0_225  0.666
2009 Edelmayer RM, Vanderah TW, Majuta L, Zhang ET, Fioravanti B, De Felice M, Chichorro JG, Ossipov MH, King T, Lai J, Kori SH, Nelsen AC, Cannon KE, Heinricher MM, Porreca F. Medullary pain facilitating neurons mediate allodynia in headache-related pain. Annals of Neurology. 65: 184-93. PMID 19259966 DOI: 10.1002/Ana.21537  0.642
2009 Zhang W, Gardell S, Zhang D, Xie JY, Agnes RS, Badghisi H, Hruby VJ, Rance N, Ossipov MH, Vanderah TW, Porreca F, Lai J. Neuropathic pain is maintained by brainstem neurons co-expressing opioid and cholecystokinin receptors. Brain : a Journal of Neurology. 132: 778-87. PMID 19050032 DOI: 10.1093/Brain/Awn330  0.815
2009 Vardanyan A, Wang R, Vanderah TW, Ossipov MH, Lai J, Porreca F, King T. TRPV1 receptor in expression of opioid-induced hyperalgesia. The Journal of Pain : Official Journal of the American Pain Society. 10: 243-52. PMID 18774343 DOI: 10.1016/J.Jpain.2008.07.004  0.724
2008 Fioravanti B, De Felice M, Stucky CL, Medler KA, Luo MC, Gardell LR, Ibrahim M, Malan TP, Yamamura HI, Ossipov MH, King T, Lai J, Porreca F, Vanderah TW. Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious chemical stimulation of TRPV1: antinociceptive actions of CB1 inverse agonists. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 11593-602. PMID 18987195 DOI: 10.1523/Jneurosci.3322-08.2008  0.714
2008 Luo MC, Chen Q, Ossipov MH, Rankin DR, Porreca F, Lai J. Spinal dynorphin and bradykinin receptors maintain inflammatory hyperalgesia. The Journal of Pain : Official Journal of the American Pain Society. 9: 1096-105. PMID 18976961 DOI: 10.1016/J.Jpain.2008.06.005  0.514
2008 Yamamoto T, Nair P, Jacobsen NE, Davis P, Ma SW, Navratilova E, Moye S, Lai J, Yamamura HI, Vanderah TW, Porreca F, Hruby VJ. The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists. Journal of Medicinal Chemistry. 51: 6334-47. PMID 18821747 DOI: 10.1021/Jm800389V  0.798
2008 Agnes RS, Ying J, Kövér KE, Lee YS, Davis P, Ma SW, Badghisi H, Porreca F, Lai J, Hruby VJ. Structure-activity relationships of bifunctional cyclic disulfide peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. Peptides. 29: 1413-23. PMID 18502541 DOI: 10.1016/J.Peptides.2008.03.022  0.589
2008 Lai J, Luo MC, Chen Q, Porreca F. Pronociceptive actions of dynorphin via bradykinin receptors. Neuroscience Letters. 437: 175-9. PMID 18450375 DOI: 10.1016/J.Neulet.2008.03.088  0.608
2008 Vanderah TW, Largent-Milnes T, Lai J, Porreca F, Houghten RA, Menzaghi F, Wisniewski K, Stalewski J, Sueiras-Diaz J, Galyean R, Schteingart C, Junien JL, Trojnar J, Rivière PJ. Novel D-amino acid tetrapeptides produce potent antinociception by selectively acting at peripheral kappa-opioid receptors. European Journal of Pharmacology. 583: 62-72. PMID 18282565 DOI: 10.1016/J.Ejphar.2008.01.011  0.703
2008 Yamamoto T, Nair P, Vagner J, Largent-Milnes T, Davis P, Ma SW, Navratilova E, Moye S, Tumati S, Lai J, Yamamura HI, Vanderah TW, Porreca F, Hruby VJ. A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists. Journal of Medicinal Chemistry. 51: 1369-76. PMID 18266313 DOI: 10.1021/Jm070332F  0.817
2008 Lee YS, Agnes RS, Cain JP, Kulkarni V, Cai M, Salibay C, Ciano K, Petrov R, Mayorov A, Vagner J, Trivedi D, Davis P, Ma SW, Lai J, Porreca F, et al. Opioid and melanocortin receptors: do they have overlapping pharmacophores? Biopolymers. 90: 433-8. PMID 17657709 DOI: 10.1002/Bip.20814  0.555
2007 Lee YS, Petrov R, Park CK, Ma SW, Davis P, Lai J, Porreca F, Vardanyan R, Hruby VJ. Development of novel enkephalin analogues that have enhanced opioid activities at both mu and delta opioid receptors. Journal of Medicinal Chemistry. 50: 5528-32. PMID 17927164 DOI: 10.1021/Jm061465O  0.575
2007 King T, Vardanyan A, Majuta L, Melemedjian O, Nagle R, Cress AE, Vanderah TW, Lai J, Porreca F. Morphine treatment accelerates sarcoma-induced bone pain, bone loss, and spontaneous fracture in a murine model of bone cancer. Pain. 132: 154-68. PMID 17706870 DOI: 10.1016/J.Pain.2007.06.026  0.797
2007 Mollica A, Guardiani G, Davis P, Ma SW, Porreca F, Lai J, Mannina L, Sobolev AP, Hruby VJ. Synthesis of stable and potent delta/mu opioid peptides: analogues of H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-OH by ring-closing metathesis. Journal of Medicinal Chemistry. 50: 3138-42. PMID 17539621 DOI: 10.1021/Jm061048B  0.488
2007 Yamamoto T, Nair P, Davis P, Ma SW, Navratilova E, Moye S, Tumati S, Lai J, Vanderah TW, Yamamura HI, Porreca F, Hruby VJ. Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists. Journal of Medicinal Chemistry. 50: 2779-86. PMID 17516639 DOI: 10.1021/Jm061369N  0.834
2007 Lee YS, Nyberg J, Moye S, Agnes RS, Davis P, Ma SW, Lai J, Porreca F, Vardanyan R, Hruby VJ. Understanding the structural requirements of 4-anilidopiperidine analogues for biological activities at mu and delta opioid receptors. Bioorganic & Medicinal Chemistry Letters. 17: 2161-5. PMID 17329100 DOI: 10.1016/J.Bmcl.2007.01.114  0.559
2007 Lee YS, Agnes RS, Davis P, Ma SW, Badghisi H, Lai J, Porreca F, Hruby VJ. Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors. Journal of Medicinal Chemistry. 50: 165-8. PMID 17201419 DOI: 10.1021/Jm061268P  0.571
2007 Zhang ET, Ossipov MH, Zhang DQ, Lai J, Porreca F. Nerve injury-induced tactile allodynia is present in the absence of FOS labeling in retrogradely labeled post-synaptic dorsal column neurons. Pain. 129: 143-54. PMID 17156921 DOI: 10.1016/j.pain.2006.10.009  0.365
2007 Vera-Portocarrero LP, Zhang ET, King T, Ossipov MH, Vanderah TW, Lai J, Porreca F. Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways. Pain. 129: 35-45. PMID 17123731 DOI: 10.1016/J.Pain.2006.09.033  0.687
2007 Fioravanti B, Ibrahim M, Luo M, DeFelice M, Zhang W, Medler K, Stucky C, Malan T, Ossipov M, Lai J, Porreca F, Vanderah T. (641) The Journal of Pain. 8: S11. DOI: 10.1016/j.jpain.2007.02.052  0.522
2006 Ndungu JM, Cain JP, Davis P, Ma SW, Vanderah TW, Lai J, Porreca F, Hruby VJ. Synthesis of constrained analogues of cholecystokinin/opioid chimeric peptides. Tetrahedron Letters. 47: 2233-2236. PMID 17203138 DOI: 10.1016/J.Tetlet.2006.01.096  0.651
2006 Lai J, Luo MC, Chen Q, Ma S, Gardell LR, Ossipov MH, Porreca F. Dynorphin A activates bradykinin receptors to maintain neuropathic pain. Nature Neuroscience. 9: 1534-40. PMID 17115041 DOI: 10.1038/Nn1804  0.59
2006 Hruby VJ, Porreca F, Yamamura HI, Tollin G, Agnes RS, Lee YS, Cai M, Alves I, Cowell S, Varga E, Davis P, Salamon Z, Roeske W, Vanderah T, Lai J. New paradigms and tools in drug design for pain and addiction. The Aaps Journal. 8: E450-60. PMID 17025262 DOI: 10.1208/Aapsj080353  0.736
2006 Petrov RR, Vardanyan RS, Lee YS, Ma SW, Davis P, Begay LJ, Lai JY, Porreca F, Hruby VJ. Synthesis and evaluation of 3-aminopropionyl substituted fentanyl analogues for opioid activity. Bioorganic & Medicinal Chemistry Letters. 16: 4946-50. PMID 16828552 DOI: 10.1016/J.Bmcl.2006.06.040  0.441
2006 Agnes RS, Lee YS, Davis P, Ma SW, Badghisi H, Porreca F, Lai J, Hruby VJ. Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. Journal of Medicinal Chemistry. 49: 2868-75. PMID 16686530 DOI: 10.1021/Jm050921Q  0.59
2006 Vera-Portocarrero LP, Zhang ET, Ossipov MH, Xie JY, King T, Lai J, Porreca F. Descending facilitation from the rostral ventromedial medulla maintains nerve injury-induced central sensitization. Neuroscience. 140: 1311-20. PMID 16650614 DOI: 10.1016/J.Neuroscience.2006.03.016  0.378
2006 Ibrahim MM, Rude ML, Stagg NJ, Mata HP, Lai J, Vanderah TW, Porreca F, Buckley NE, Makriyannis A, Malan TP. CB2 cannabinoid receptor mediation of antinociception. Pain. 122: 36-42. PMID 16563625 DOI: 10.1016/J.Pain.2005.12.018  0.677
2006 Lee YS, Agnes RS, Badghisi H, Davis P, Ma SW, Lai J, Porreca F, Hruby VJ. Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists. Journal of Medicinal Chemistry. 49: 1773-80. PMID 16509592 DOI: 10.1021/Jm050851N  0.557
2006 Gardell LR, King T, Ossipov MH, Rice KC, Lai J, Vanderah TW, Porreca F. Opioid receptor-mediated hyperalgesia and antinociceptive tolerance induced by sustained opiate delivery. Neuroscience Letters. 396: 44-9. PMID 16343768 DOI: 10.1016/J.Neulet.2005.11.009  0.699
2006 Mollica A, Davis P, Ma SW, Porreca F, Lai J, Hruby VJ. Synthesis and biological activity of the first cyclic biphalin analogues. Bioorganic & Medicinal Chemistry Letters. 16: 367-72. PMID 16275086 DOI: 10.1016/J.Bmcl.2005.09.080  0.35
2006 Dogrul A, Ossipov M, Lai J, Porreca F. P.1.c.049 Descending serotonergic pathways play an inhibitory or facilitatory role in spinal pain processing by 5-HT7 or 5-HT3 receptors in acute and chronic pain European Neuropsychopharmacology. 16: S249-S250. DOI: 10.1016/S0924-977X(06)70217-6  0.368
2006 Vardanyan A, King T, Melemedjian O, Majuta L, Lai J, Porreca F. (330/631) The Journal of Pain. 7: S8. DOI: 10.1016/J.Jpain.2006.01.435  0.443
2006 Ibrahim M, Rude M, Stagg N, Mata H, Lai J, Vanderah T, Porreca F, Buckley N, Makriyannis A, Malan T. CB2 cannabinoid receptor mediation of antinociception Acute Pain. 8: 142. DOI: 10.1016/j.acpain.2006.08.026  0.618
2005 Dogrul A, Bilsky EJ, Ossipov MH, Lai J, Porreca F. Spinal L-type calcium channel blockade abolishes opioid-induced sensory hypersensitivity and antinociceptive tolerance. Anesthesia and Analgesia. 101: 1730-5. PMID 16301251 DOI: 10.1213/01.ANE.0000184253.49849.B0  0.407
2005 King T, Ossipov MH, Vanderah TW, Porreca F, Lai J. Is paradoxical pain induced by sustained opioid exposure an underlying mechanism of opioid antinociceptive tolerance? Neuro-Signals. 14: 194-205. PMID 16215302 DOI: 10.1159/000087658  0.723
2005 Luo MC, Zhang DQ, Ma SW, Huang YY, Shuster SJ, Porreca F, Lai J. An efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons. Molecular Pain. 1: 29. PMID 16191203 DOI: 10.1186/1744-8069-1-29  0.423
2005 Svensson CI, Hua XY, Powell HC, Lai J, Porreca F, Yaksh TL. Prostaglandin E2 release evoked by intrathecal dynorphin is dependent on spinal p38 mitogen activated protein kinase. Neuropeptides. 39: 485-94. PMID 16176831 DOI: 10.1016/J.Npep.2005.08.002  0.43
2005 King T, Gardell LR, Wang R, Vardanyan A, Ossipov MH, Malan TP, Vanderah TW, Hunt SP, Hruby VJ, Lai J, Porreca F. Role of NK-1 neurotransmission in opioid-induced hyperalgesia. Pain. 116: 276-88. PMID 15964684 DOI: 10.1016/J.Pain.2005.04.014  0.693
2005 Mollica A, Davis P, Ma SW, Lai J, Porreca F, Hruby VJ. Synthesis and biological evaluation of new biphalin analogues with non-hydrazine linkers. Bioorganic & Medicinal Chemistry Letters. 15: 2471-5. PMID 15863299 DOI: 10.1016/J.Bmcl.2005.03.067  0.425
2005 Ossipov MH, Lai J, King T, Vanderah TW, Porreca F. Underlying mechanisms of pronociceptive consequences of prolonged morphine exposure. Biopolymers. 80: 319-24. PMID 15795927 DOI: 10.1002/Bip.20254  0.682
2005 Ibrahim MM, Porreca F, Lai J, Albrecht PJ, Rice FL, Khodorova A, Davar G, Makriyannis A, Vanderah TW, Mata HP, Malan TP. CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids. Proceedings of the National Academy of Sciences of the United States of America. 102: 3093-8. PMID 15705714 DOI: 10.1073/Pnas.0409888102  0.709
2005 Xie JY, Herman DS, Stiller CO, Gardell LR, Ossipov MH, Lai J, Porreca F, Vanderah TW. Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 409-16. PMID 15647484 DOI: 10.1523/Jneurosci.4054-04.2005  0.709
2005 Vera-Portocarrero L, King T, Vanderah T, Lai J, Porreca F. Ablation of NK-1 expressing cells in the spinal dorsal horn prevents the development of opioid-induced hyperalgesia and antinociceptive tolerance The Journal of Pain. 6: S17. DOI: 10.1016/J.Jpain.2005.01.065  0.662
2004 Ossipov MH, Lai J, King T, Vanderah TW, Malan TP, Hruby VJ, Porreca F. Antinociceptive and nociceptive actions of opioids. Journal of Neurobiology. 61: 126-48. PMID 15362157 DOI: 10.1002/Neu.20091  0.671
2004 Chen Q, King T, Vanderah TW, Ossipov MH, Malan TP, Lai J, Porreca F. Differential blockade of nerve injury-induced thermal and tactile hypersensitivity by systemically administered brain-penetrating and peripherally restricted local anesthetics. The Journal of Pain : Official Journal of the American Pain Society. 5: 281-9. PMID 15219260 DOI: 10.1016/J.Jpain.2004.05.002  0.571
2004 Quartilho A, Mata HP, Ibrahim MM, Vanderah TW, Ossipov MH, Lai J, Porreca F, Malan TP. Production of paradoxical sensory hypersensitivity by alpha 2-adrenoreceptor agonists. Anesthesiology. 100: 1538-44. PMID 15166576 DOI: 10.1097/00000542-200406000-00029  0.662
2004 Vanderah TW, Schteingart CD, Trojnar J, Junien JL, Lai J, Riviere PJ. FE200041 (D-Phe-D-Phe-D-Nle-D-Arg-NH2): A peripheral efficacious kappa opioid agonist with unprecedented selectivity. The Journal of Pharmacology and Experimental Therapeutics. 310: 326-33. PMID 14993260 DOI: 10.1124/jpet.104.065391  0.711
2004 Koetzner L, Hua XY, Lai J, Porreca F, Yaksh T. Nonopioid actions of intrathecal dynorphin evoke spinal excitatory amino acid and prostaglandin E2 release mediated by cyclooxygenase-1 and -2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 1451-8. PMID 14960618 DOI: 10.1523/JNEUROSCI.1517-03.2004  0.353
2004 Gardell LR, Ibrahim M, Wang R, Wang Z, Ossipov MH, Malan TP, Porreca F, Lai J. Mouse strains that lack spinal dynorphin upregulation after peripheral nerve injury do not develop neuropathic pain. Neuroscience. 123: 43-52. PMID 14667440 DOI: 10.1016/J.Neuroscience.2003.08.021  0.407
2004 Wang R, Guo W, Ossipov M, Vanderah T, Porreca F, Lai J. Erratum to “glial cell line-derived neurotrophic factor normalizes neurochemical changes in injured dorsal root ganglion neurons and prevents the expression of experimental neuropathic pain” Neuroscience. 126: 247. DOI: 10.1016/J.Neuroscience.2004.03.032  0.531
2003 Wang R, Guo W, Ossipov MH, Vanderah TW, Porreca F, Lai J. Glial cell line-derived neurotrophic factor normalizes neurochemical changes in injured dorsal root ganglion neurons and prevents the expression of experimental neuropathic pain. Neuroscience. 121: 815-24. PMID 14568039 DOI: 10.1016/S0306-4522(03)00491-3  0.636
2003 Gardell LR, Wang R, Ehrenfels C, Ossipov MH, Rossomando AJ, Miller S, Buckley C, Cai AK, Tse A, Foley SF, Gong B, Walus L, Carmillo P, Worley D, Huang C, ... ... Lai J, et al. Multiple actions of systemic artemin in experimental neuropathy. Nature Medicine. 9: 1383-9. PMID 14528299 DOI: 10.1038/Nm944  0.604
2003 Dogrul A, Gardell LR, Ossipov MH, Tulunay FC, Lai J, Porreca F. Reversal of experimental neuropathic pain by T-type calcium channel blockers. Pain. 105: 159-68. PMID 14499432 DOI: 10.1016/S0304-3959(03)00177-5  0.371
2003 Gardell LR, Vanderah TW, Gardell SE, Wang R, Ossipov MH, Lai J, Porreca F. Enhanced evoked excitatory transmitter release in experimental neuropathy requires descending facilitation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 8370-9. PMID 12967999 DOI: 10.1523/Jneurosci.23-23-08370.2003  0.787
2003 Ibrahim MM, Deng H, Zvonok A, Cockayne DA, Kwan J, Mata HP, Vanderah TW, Lai J, Porreca F, Makriyannis A, Malan TP. Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS. Proceedings of the National Academy of Sciences of the United States of America. 100: 10529-33. PMID 12917492 DOI: 10.1073/Pnas.1834309100  0.7
2003 Lai J, Hunter JC, Porreca F. The role of voltage-gated sodium channels in neuropathic pain. Current Opinion in Neurobiology. 13: 291-7. PMID 12850213 DOI: 10.1016/S0959-4388(03)00074-6  0.357
2003 Ossipov MH, Lai J, Vanderah TW, Porreca F. Induction of pain facilitation by sustained opioid exposure: relationship to opioid antinociceptive tolerance. Life Sciences. 73: 783-800. PMID 12801599 DOI: 10.1016/S0024-3205(03)00410-7  0.708
2003 Hruby VJ, Agnes RS, Davis P, Ma SW, Lee YS, Vanderah TW, Lai J, Porreca F. Design of novel peptide ligands which have opioid agonist activity and CCK antagonist activity for the treatment of pain. Life Sciences. 73: 699-704. PMID 12801591 DOI: 10.1016/S0024-3205(03)00390-4  0.695
2003 Malan TP, Ibrahim MM, Lai J, Vanderah TW, Makriyannis A, Porreca F. CB2 cannabinoid receptor agonists: pain relief without psychoactive effects? Current Opinion in Pharmacology. 3: 62-7. PMID 12550743 DOI: 10.1016/S1471-4892(02)00004-8  0.685
2003 Gold MS, Weinreich D, Kim CS, Wang R, Treanor J, Porreca F, Lai J. Redistribution of Na(V)1.8 in uninjured axons enables neuropathic pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 158-66. PMID 12514212 DOI: 10.1523/Jneurosci.23-01-00158.2003  0.375
2002 Gardell LR, Ossipov MH, Vanderah TW, Lai J, Porreca F. Dynorphin-independent spinal cannabinoid antinociception. Pain. 100: 243-8. PMID 12467995 DOI: 10.1016/S0304-3959(02)00173-2  0.711
2002 Dogrul A, Gardell LR, Ma S, Ossipov MH, Porreca F, Lai J. 'Knock-down' of spinal CB1 receptors produces abnormal pain and elevates spinal dynorphin content in mice. Pain. 100: 203-9. PMID 12435473 DOI: 10.1016/S0304-3959(02)00302-0  0.48
2002 Ossipov MH, Zhang ET, Carvajal C, Gardell L, Quirion R, Dumont Y, Lai J, Porreca F. Selective mediation of nerve injury-induced tactile hypersensitivity by neuropeptide Y. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 9858-67. PMID 12427842 DOI: 10.1523/Jneurosci.22-22-09858.2002  0.339
2002 Gardell LR, Wang R, Burgess SE, Ossipov MH, Vanderah TW, Malan TP, Lai J, Porreca F. Sustained morphine exposure induces a spinal dynorphin-dependent enhancement of excitatory transmitter release from primary afferent fibers. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 6747-55. PMID 12151554 DOI: 10.1523/Jneurosci.22-15-06747.2002  0.681
2002 Gardell LR, Burgess SE, Dogrul A, Ossipov MH, Malan TP, Lai J, Porreca F. Pronociceptive effects of spinal dynorphin promote cannabinoid-induced pain and antinociceptive tolerance. Pain. 98: 79-88. PMID 12098619 DOI: 10.1016/S0304-3959(01)00475-4  0.509
2002 Burgess SE, Gardell LR, Ossipov MH, Malan TP, Vanderah TW, Lai J, Porreca F. Time-dependent descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 5129-36. PMID 12077208 DOI: 10.1523/Jneurosci.22-12-05129.2002  0.648
2002 Lai J, Gold MS, Kim CS, Bian D, Ossipov MH, Hunter JC, Porreca F. Inhibition of neuropathic pain by decreased expression of the tetrodotoxin-resistant sodium channel, NaV1.8. Pain. 95: 143-52. PMID 11790477 DOI: 10.1016/S0304-3959(01)00391-8  0.411
2001 Ibrahim MM, Mata HP, Chawla M, Lai J, Porreca F, Malan TP. Allodynia and hyperalgesia produced by specific inhibition of spinal c-fos expression: lack of correlation with dynorphin content. The Journal of Pain : Official Journal of the American Pain Society. 2: 241-9. PMID 14622822 DOI: 10.1054/Jpai.2001.23135  0.363
2001 Rasband MN, Park EW, Vanderah TW, Lai J, Porreca F, Trimmer JS. Distinct potassium channels on pain-sensing neurons. Proceedings of the National Academy of Sciences of the United States of America. 98: 13373-8. PMID 11698689 DOI: 10.1073/Pnas.231376298  0.555
2001 Porreca F, Burgess SE, Gardell LR, Vanderah TW, Malan TP, Ossipov MH, Lappi DA, Lai J. Inhibition of neuropathic pain by selective ablation of brainstem medullary cells expressing the mu-opioid receptor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 5281-8. PMID 11438603 DOI: 10.1523/Jneurosci.21-14-05281.2001  0.741
2001 Vanderah TW, Ossipov MH, Lai J, Malan TP, Porreca F. Mechanisms of opioid-induced pain and antinociceptive tolerance: descending facilitation and spinal dynorphin. Pain. 92: 5-9. PMID 11323121 DOI: 10.1016/S0304-3959(01)00311-6  0.7
2001 Wang Z, Gardell LR, Ossipov MH, Vanderah TW, Brennan MB, Hochgeschwender U, Hruby VJ, Malan TP, Lai J, Porreca F. Pronociceptive actions of dynorphin maintain chronic neuropathic pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 1779-86. PMID 11222667 DOI: 10.1523/Jneurosci.21-05-01779.2001  0.633
2001 Sun H, Ren K, Zhong CM, Ossipov MH, Malan TP, Lai J, Porreca F. Nerve injury-induced tactile allodynia is mediated via ascending spinal dorsal column projections. Pain. 90: 105-11. PMID 11166976 DOI: 10.1016/S0304-3959(00)00392-4  0.362
2001 Xu H, Hashimoto A, Rice KC, Jacobson AE, Thomas JB, Carroll FI, Lai J, Rothman RB. Opioid peptide receptor studies. 14. Stereochemistry determines agonist efficacy and intrinsic efficacy in the [(35)S]GTP-gamma-S functional binding assay. Synapse (New York, N.Y.). 39: 64-9. PMID 11071711 DOI: 10.1002/1098-2396(20010101)39:1<64::Aid-Syn9>3.0.Co;2-J  0.483
2000 Dogrul A, Ossipov MH, Lai J, Malan TP, Porreca F. Peripheral and spinal antihyperalgesic activity of SIB-1757, a metabotropic glutamate receptor (mGLUR(5)) antagonist, in experimental neuropathic pain in rats. Neuroscience Letters. 292: 115-8. PMID 10998562 DOI: 10.1016/S0304-3940(00)01458-0  0.503
2000 Vanderah TW, Gardell LR, Burgess SE, Ibrahim M, Dogrul A, Zhong CM, Zhang ET, Malan TP, Ossipov MH, Lai J, Porreca F. Dynorphin promotes abnormal pain and spinal opioid antinociceptive tolerance. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 7074-9. PMID 10995854 DOI: 10.1523/Jneurosci.20-18-07074.2000  0.708
2000 Kovelowski CJ, Ossipov MH, Sun H, Lai J, Malan TP, Porreca F. Supraspinal cholecystokinin may drive tonic descending facilitation mechanisms to maintain neuropathic pain in the rat. Pain. 87: 265-73. PMID 10963906 DOI: 10.1016/S0304-3959(00)00290-6  0.485
2000 Ossipov MH, Hong Sun T, Malan P, Lai J, Porreca F. Mediation of spinal nerve injury induced tactile allodynia by descending facilitatory pathways in the dorsolateral funiculus in rats. Neuroscience Letters. 290: 129-32. PMID 10936694 DOI: 10.1016/S0304-3940(00)01338-0  0.359
2000 Ossipov MH, Lai J, Malan TP, Porreca F. Spinal and supraspinal mechanisms of neuropathic pain. Annals of the New York Academy of Sciences. 909: 12-24. PMID 10911921 DOI: 10.1111/J.1749-6632.2000.Tb06673.X  0.521
2000 Tang Q, Lynch RM, Porreca F, Lai J. Dynorphin A elicits an increase in intracellular calcium in cultured neurons via a non-opioid, non-NMDA mechanism. Journal of Neurophysiology. 83: 2610-5. PMID 10805661 DOI: 10.1152/Jn.2000.83.5.2610  0.632
2000 Malan TP, Ossipov MH, Gardell LR, Ibrahim M, Bian D, Lai J, Porreca F. Extraterritorial neuropathic pain correlates with multisegmental elevation of spinal dynorphin in nerve-injured rats. Pain. 86: 185-94. PMID 10779675 DOI: 10.1016/S0304-3959(00)00243-8  0.419
2000 Hosohata Y, Vanderah TW, Burkey TH, Ossipov MH, Kovelowski CJ, Sora I, Uhl GR, Zhang X, Rice KC, Roeske WR, Hruby VJ, Yamamura HI, Lai J, Porreca F. delta-Opioid receptor agonists produce antinociception and [35S]GTPgammaS binding in mu receptor knockout mice. European Journal of Pharmacology. 388: 241-8. PMID 10675732 DOI: 10.1016/S0014-2999(99)00897-3  0.726
2000 Lai J, Hunter JC, Ossipov MH, Porreca F. Blockade of neuropathic pain by antisense targeting of tetrodotoxin-resistant sodium channels in sensory neurons. Methods in Enzymology. 314: 201-13. PMID 10565014 DOI: 10.1016/S0076-6879(99)14104-1  0.394
1999 Kovelowski CJ, Bian D, Hruby VJ, Lai J, Ossipov MH, Porreca F. Selective opioid delta agonists elicit antinociceptive supraspinal/spinal synergy in the rat. Brain Research. 843: 12-7. PMID 10528105 DOI: 10.1016/S0006-8993(99)01803-X  0.568
1999 Romero DV, Partilla JS, Zheng Q, Heyliger SO, Ni Q, Rice KC, Lai J, Rothman RB. Opioid peptide receptor studies. 12. Buprenorphine is a potent and selective mu/kappa antagonist in the [35S]-GTP-gamma-S functional binding assay. Synapse. 34: 83-94. PMID 10502307 DOI: 10.1002/(Sici)1098-2396(199911)34:2<83::Aid-Syn1>3.0.Co;2-S  0.482
1999 Bian D, Ossipov MH, Ibrahim M, Raffa RB, Tallarida RJ, Malan TP, Lai J, Porreca F. Loss of antiallodynic and antinociceptive spinal/supraspinal morphine synergy in nerve-injured rats: restoration by MK-801 or dynorphin antiserum. Brain Research. 831: 55-63. PMID 10411983 DOI: 10.1016/S0006-8993(99)01393-1  0.478
1999 Porreca F, Lai J, Bian D, Wegert S, Ossipov MH, Eglen RM, Kassotakis L, Novakovic S, Rabert DK, Sangameswaran L, Hunter JC. A comparison of the potential role of the tetrodotoxin-insensitive sodium channels, PN3/SNS and NaN/SNS2, in rat models of chronic pain. Proceedings of the National Academy of Sciences of the United States of America. 96: 7640-4. PMID 10393873 DOI: 10.1073/pnas.96.14.7640  0.386
1999 Ossipov MH, Bian D, Malan TP, Lai J, Porreca F. Lack of involvement of capsaicin-sensitive primary afferents in nerve-ligation injury induced tactile allodynia in rats. Pain. 79: 127-33. PMID 10068158 DOI: 10.1016/S0304-3959(98)00187-0  0.348
1998 Ni Q, Xu H, Partilla JS, Rice KC, Matecka D, Calderon SN, Porreca F, Lai J, Schmidhammer H, Krassnig R, Rothman RB. Opioid peptide receptor studies. 9. Identification of a novel non-mu- non-delta-like opioid peptide binding site in rat brain. Peptides. 19: 1079-90. PMID 9700759 DOI: 10.1016/S0196-9781(98)00046-1  0.393
1998 Porreca F, Tang QB, Bian D, Riedl M, Elde R, Lai J. Spinal opioid mu receptor expression in lumbar spinal cord of rats following nerve injury. Brain Research. 795: 197-203. PMID 9622629 DOI: 10.1016/S0006-8993(98)00292-3  0.704
1998 Xu H, Lu YF, Partilla JS, Pinto J, Calderon SN, Matecka D, Rice KC, Lai J, Porreca F, Ananthan S, Rothman RB. Opioid peptide receptor studies. 8. One of the mouse brain deltaNCX binding sites is similar to the cloned mouse opioid delta receptor: further evidence for heterogeneity of delta opioid receptors. Peptides. 19: 343-50. PMID 9493867 DOI: 10.1016/S0196-9781(97)00294-5  0.495
1998 Lu YF, Xu H, Liu-Chen LY, Chen C, Partilla JS, Brine GA, Carroll FI, Rice KC, Lai J, Porreca F, Sadee W, Rothman RB. Opioid peptide receptor studies. 7. The methylfentanyl congener RTI-4614-4 and its four enantiomers bind to different domains of the rat mu opioid receptor. Synapse (New York, N.Y.). 28: 117-24. PMID 9450512 DOI: 10.1002/(Sici)1098-2396(199802)28:2<117::Aid-Syn2>3.0.Co;2-E  0.514
1997 St John PA, Ludwig CP, Lai J. Substance P receptor expression and cellular responses to substance P in prenatal rat spinal cord cells. Journal of Receptor and Signal Transduction Research. 17: 569-83. PMID 9220368 DOI: 10.3109/10799899709039150  0.335
1997 Xu H, Lu Y, Partilla JS, Brine GA, Carroll FI, Rice KC, Lai J, Porreca F, Rothman RB. Opioid Peptide Receptor Studies. 6. The 3-Methylfentanyl Congeners RTI-4614-4 and Its Enantiomers Differ in Efficacy, Potency, and Intrinsic Efficacy as Measured by Stimulation of [35S]GTP-γ-S Binding Using Cloned μ-Opioid Receptors Analgesia. 3: 35-42. DOI: 10.3727/107156997819566037  0.455
1996 Bilsky EJ, Wang T, Lai J, Porreca F. Selective blockade of peripheral delta opioid agonist induced antinociception by intrathecal administration of delta receptor antisense oligodeoxynucleotide. Neuroscience Letters. 220: 155-8. PMID 8994216 DOI: 10.1016/S0304-3940(96)13262-6  0.531
1996 Lai J, Ma SW, Porreca F, Raffa RB. Tramadol, M1 metabolite and enantiomer affinities for cloned human opioid receptors expressed in transfected HN9.10 neuroblastoma cells. European Journal of Pharmacology. 316: 369-72. PMID 8982709 DOI: 10.1016/S0014-2999(96)00770-4  0.513
1996 Lai J, Riedl M, Stone LS, Arvidsson U, Bilsky EJ, Wilcox GL, Elde R, Porreca F. Immunofluorescence analysis of antisense oligodeoxynucleotide-mediated 'knock-down' of the mouse delta opioid receptor in vitro and in vivo. Neuroscience Letters. 213: 205-8. PMID 8873150 DOI: 10.1016/0304-3940(96)12883-4  0.513
1996 Zaki PA, Bilsky EJ, Vanderah TW, Lai J, Evans CJ, Porreca F. Opioid receptor types and subtypes: the delta receptor as a model. Annual Review of Pharmacology and Toxicology. 36: 379-401. PMID 8725395 DOI: 10.1146/Annurev.Pa.36.040196.002115  0.701
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1995 Cha XY, Xu H, Ni Q, Partilla JS, Rice KC, Matecka D, Calderon SN, Porreca F, Lai J, Rothman RB. Opioid peptide receptor studies. 4. Antisense oligodeoxynucleotide to the delta opioid receptor delineates opioid receptor subtypes Regulatory Peptides. 59: 247-253. PMID 8584761 DOI: 10.1016/0167-0115(95)00095-S  0.495
1995 Bian D, Nichols ML, Ossipov MH, Lai J, Porreca F. Characterization of the antiallodynic efficacy of morphine in a model of neuropathic pain in rats. Neuroreport. 6: 1981-4. PMID 8580422 DOI: 10.1097/00001756-199510010-00007  0.57
1995 Cha XY, Xu H, Rice KC, Porreca F, Lai J, Ananthan S, Rothman RB. Opioid peptide receptor studies. 1. Identification of a novel delta-opioid receptor binding site in rat brain membranes. Peptides. 16: 191-8. PMID 7784248 DOI: 10.1016/0196-9781(94)00182-0  0.436
1995 Mayfield KP, Horvath R, Lai J, Porreca F. Increased expression of opioid delta receptors by deoxy conformation heme proteins in NG108-15 cells Brain Research. 676: 358-362. PMID 7614006 DOI: 10.1016/0006-8993(95)00089-9  0.359
1995 Lai J, Crook T, Payne A, Porreca F. ANTISENSE OLIGODEOXYNUCLEOTIDE-MEDIATED REDUCTION IN THE δ OPIOID RECEPTORS: DIRECT CORRELATION BETWEEN ANTISENSE UPTAKE AND RECEPTOR “KNOCK-DOWN" Analgesia. 1: 535-538. DOI: 10.3727/107156995819564121  0.431
1995 Vanderah TW, Bernstein RN, Lai J, Porreca F. PRODUCTION OF NALTRINDOLE-SENSITIVE ANTINOCICEPTION BY A CHOLECYSTOKININ (CCK) ANTAGONIST AND THIORPHAN: EVIDENCE FOR TONIC INHIBITION OF ENKEPHALIN RELEASE BY CCK Analgesia. 1: 813-816. DOI: 10.3727/107156995819563546  0.524
1994 Lai J, Bilsky EJ, Rothman RB, Porreca F. Treatment with antisense oligodeoxynucleotide to the opioid δ receptor selectively inhibits δ<inf>2</inf>-agonist antinociception Neuroreport. 5: 1049-1052. PMID 8080957 DOI: 10.1097/00001756-199405000-00008  0.53
1994 Bilsky EJ, Bernstein RN, Pasternak GW, Hruby VJ, Patel D, Porreca F, Lai J. Selective inhibition of [D-ALA2, GLU4]deltrophin antinociception by supraspinal, but not spinal, administration of an antisense oligodeoxynucleotide to an opioid delta receptor Life Sciences. 55: PL37-PL43. PMID 8015351 DOI: 10.1016/0024-3205(94)90110-4  0.478
1994 Lai J, Rothman RB, Lentes KU, Ma SW, Doble A, Zhu RH, Porreca F. Pharmacological characterization of the cloned kappa opioid receptor as a kappa<inf>1b</inf> subtype Neuroreport. 5: 2161-2164. PMID 7865767 DOI: 10.1097/00001756-199410270-00043  0.374
1994 Vanderah TW, Lai J, Yamamura HI, Porreca F. Antisense oligodeoxynucleotide to the CCKB receptor produces naltrindole- and [Leu5]enkephalin antiserum-sensitive enhancement of morphine antinociception. Neuroreport. 5: 2601-5. PMID 7696612 DOI: 10.1097/00001756-199412000-00049  0.757
1994 Mayfield KP, Lai J, Porreca F. Selective upregulation of opioid delta receptors in NG 108-15 cells by treatment with cobalt: Possible hypoxic regulation Regulatory Peptides. 54: 183-184. DOI: 10.1016/0167-0115(94)90451-0  0.509
1994 Lai J, Bilsky EJ, Bernstein RN, Rothman RB, Pasternak GW, Porreca F. Antisense oligodeoxynucleotide to the cloned delta opioid receptor selectively inhibits supraspinal, but not spinal, antinociceptive effects of [D-Ala2, Glu4]deltorphin Regulatory Peptides. 54: 159-160. DOI: 10.1016/0167-0115(94)90439-1  0.542
1992 Wei HB, Roeske WR, Lai J, Wanibuchi F, Hidaka K, Usuda S, Yamamura HI. Pharmacological characterization of a novel muscarinic partial agonist, YM796, in transfected cells expressing the m1 or m2 muscarinic receptor gene. Life Sciences. 50: 355-63. PMID 1310135 DOI: 10.1016/0024-3205(92)90437-T  0.521
1992 Lai J, Roeske W, Yamamura HI. Structure-function correlation of muscarinic acetylfholine receptors European Neuropsychopharmacology. 2: 227-228. DOI: 10.1016/0924-977X(92)90078-M  0.525
1991 Lai J, Smith TL, Mei L, Ikeda M, Fujiwara Y, Gomez J, Halonen M, Roeske WR, Yamamura HI. The molecular properties of the M1 muscarinic receptor and its regulation of cytosolic calcium in a eukaryotic gene expression system. Advances in Experimental Medicine and Biology. 287: 313-30. PMID 1759615 DOI: 10.1007/978-1-4684-5907-4_26  0.618
1990 Lai J, Bloom JW, Yamamura HI, Roeske WR. Amplification of the rat M2 muscarinic receptor gene by the polymerase chain reaction: functional expression of the M2 muscarinic receptor. Life Sciences. 47: 1001-13. PMID 2172674 DOI: 10.1016/0024-3205(90)90472-4  0.539
1990 Henderson AK, Lai J, Buck SH, Fujiwara Y, Singh G, Yamamura MS, Nakanishi S, Roeske WR, Yamamura HI. Accelerated communication a cloned NK2 receptor mediates phosphatidylinositol hydrolysis in a transfected murine fibrolast Life Sciences. 47: PL7-PL12. DOI: 10.1016/0024-3205(90)90329-P  0.568
1990 Roeske WR, Lai J, Mei L, Bloom JW, Yamamura HI. Pharmacologic comparison of the cloned M1 and M2 muscarinic receptors of the rat expressed in murine fibroblast cells European Journal of Pharmacology. 183: 1618. DOI: 10.1016/0014-2999(90)91905-Q  0.587
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