Jonathon Howard - Publications

Affiliations: 
1989-2001 Physiology & Biophysics University of Washington, Seattle, Seattle, WA 
 2000-2013 Max Planck Institute for Cell Biology and Genetics, Dresden, Dresden, Sachsen, Germany 
 2013- Molecular Biophysics & Biochemistry Yale University, New Haven, CT 
Area:
Motor Proteins, Cytoskeleton
Website:
https://medicine.yale.edu/mbb/faculty/jonathon_howard.profile

70 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Mahamdeh M, Simmert S, Luchniak A, Schäffer E, Howard J. Label-free high-speed wide-field imaging of single microtubules using interference reflection microscopy. Journal of Microscopy. PMID 30044498 DOI: 10.1111/jmi.12744  0.76
2016 Coombes C, Yamamoto A, McClellan M, Reid TA, Plooster M, Luxton GW, Alper J, Howard J, Gardner MK. Mechanism of microtubule lumen entry for the α-tubulin acetyltransferase enzyme αTAT1. Proceedings of the National Academy of Sciences of the United States of America. PMID 27803321 DOI: 10.1073/pnas.1605397113  1
2016 Pécréaux J, Redemann S, Alayan Z, Mercat B, Pastezeur S, Garzon-Coral C, Hyman AA, Howard J. The Mitotic Spindle in the One-Cell C. elegans Embryo Is Positioned with High Precision and Stability. Biophysical Journal. 111: 1773-1784. PMID 27760363 DOI: 10.1016/j.bpj.2016.09.007  0.44
2016 Garzon-Coral C, Fantana HA, Howard J. A force-generating machinery maintains the spindle at the cell center during mitosis. Science (New York, N.Y.). 352: 1124-7. PMID 27230381 DOI: 10.1126/science.aad9745  1
2016 Sartori P, Geyer VF, Scholich A, Jülicher F, Howard J. Dynamic curvature regulation accounts for the symmetric and asymmetric beats of Chlamydomonas flagella. Elife. 5. PMID 27166516 DOI: 10.7554/eLife.13258  1
2016 Battle C, Broedersz CP, Fakhri N, Geyer VF, Howard J, Schmidt CF, MacKintosh FC. Broken detailed balance at mesoscopic scales in active biological systems. Science (New York, N.Y.). 352: 604-7. PMID 27126047 DOI: 10.1126/science.aac8167  1
2016 Xiao X, Geyer VF, Bowne-Anderson H, Howard J, Sbalzarini IF. Automatic optimal filament segmentation with sub-pixel accuracy using generalized linear models and B-spline level-sets. Medical Image Analysis. 32: 157-172. PMID 27104582 DOI: 10.1016/j.media.2016.03.007  1
2016 Borisy G, Heald R, Howard J, Janke C, Musacchio A, Nogales E. Microtubules: 50 years on from the discovery of tubulin. Nature Reviews. Molecular Cell Biology. 17: 322-8. PMID 27103327 DOI: 10.1038/nrm.2016.45  1
2016 Geyer VF, Sartori P, Friedrich BM, Jülicher F, Howard J. Independent Control of the Static and Dynamic Components of the Chlamydomonas Flagellar Beat. Current Biology : Cb. PMID 27040779 DOI: 10.1016/j.cub.2016.02.053  1
2016 Carrillo Oesterreich F, Herzel L, Straube K, Hujer K, Howard J, Neugebauer KM. Splicing of Nascent RNA Coincides with Intron Exit from RNA Polymerase II. Cell. PMID 27020755 DOI: 10.1016/j.cell.2016.02.045  1
2015 Bowne-Anderson H, Hibbel A, Howard J. Regulation of Microtubule Growth and Catastrophe: Unifying Theory and Experiment. Trends in Cell Biology. PMID 26616192 DOI: 10.1016/j.tcb.2015.08.009  1
2015 Hibbel A, Bogdanova A, Mahamdeh M, Jannasch A, Storch M, Schäffer E, Liakopoulos D, Howard J. Kinesin Kip2 enhances microtubule growth in vitro through length-dependent feedback on polymerization and catastrophe. Elife. 4. PMID 26576948 DOI: 10.7554/eLife.10542  1
2014 Gardner MK, Charlebois BD, Jánosi IM, Howard J, Hunt AJ, Odde DJ. Rapid Microtubule Self-Assembly Kinetics. Cell. 159: 215. PMID 28934602 DOI: 10.1016/j.cell.2014.09.017  1
2014 Alper JD, Decker F, Agana B, Howard J. The motility of axonemal dynein is regulated by the tubulin code. Biophysical Journal. 107: 2872-80. PMID 25658008  0.44
2014 Podolski M, Mahamdeh M, Howard J. Stu2, the budding yeast XMAP215/Dis1 homolog, promotes assembly of yeast microtubules by increasing growth rate and decreasing catastrophe frequency. The Journal of Biological Chemistry. 289: 28087-93. PMID 25172511 DOI: 10.1074/jbc.M114.584300  0.36
2013 Howard J, McIntosh JR, Odde DJ. A brief scientific biography of Prof. Alan J. Hunt. Cellular and Molecular Bioengineering. 6: 356-360. PMID 24683426 DOI: 10.1007/s12195-013-0301-z  1
2013 Geyer VF, Jülicher F, Howard J, Friedrich BM. Cell-body rocking is a dominant mechanism for flagellar synchronization in a swimming alga. Proceedings of the National Academy of Sciences of the United States of America. 110: 18058-63. PMID 24145440 DOI: 10.1073/pnas.1300895110  1
2013 Takeshita N, Mania D, Herrero S, Ishitsuka Y, Nienhaus GU, Podolski M, Howard J, Fischer R. The cell-end marker TeaA and the microtubule polymerase AlpA contribute to microtubule guidance at the hyphal tip cortex of Aspergillus nidulans to provide polarity maintenance. Journal of Cell Science. 126: 5400-11. PMID 24101725 DOI: 10.1242/jcs.129841  0.36
2013 Reber SB, Baumgart J, Widlund PO, Pozniakovsky A, Howard J, Hyman AA, Jülicher F. XMAP215 activity sets spindle length by controlling the total mass of spindle microtubules. Nature Cell Biology. 15: 1116-22. PMID 23974040 DOI: 10.1038/ncb2834  1
2013 Jannasch A, Bormuth V, Storch M, Howard J, Schäffer E. Kinesin-8 is a low-force motor protein with a weakly bound slip state. Biophysical Journal. 104: 2456-64. PMID 23746518 DOI: 10.1016/j.bpj.2013.02.040  0.76
2013 Zanic M, Widlund PO, Hyman AA, Howard J. Synergy between XMAP215 and EB1 increases microtubule growth rates to physiological levels. Nature Cell Biology. 15: 688-93. PMID 23666085 DOI: 10.1038/ncb2744  1
2013 Alper JD, Tovar M, Howard J. Displacement-weighted velocity analysis of gliding assays reveals that Chlamydomonas axonemal dynein preferentially moves conspecific microtubules. Biophysical Journal. 104: 1989-98. PMID 23663842 DOI: 10.1016/j.bpj.2013.03.041  1
2013 Bowne-Anderson H, Zanic M, Kauer M, Howard J. Microtubule dynamic instability: a new model with coupled GTP hydrolysis and multistep catastrophe. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 35: 452-61. PMID 23532586 DOI: 10.1002/bies.201200131  1
2013 Alper J, Geyer V, Mukundan V, Howard J. Reconstitution of flagellar sliding. Methods in Enzymology. 524: 343-69. PMID 23498749 DOI: 10.1016/B978-0-12-397945-2.00019-6  1
2013 Gardner MK, Zanic M, Howard J. Microtubule catastrophe and rescue. Current Opinion in Cell Biology. 25: 14-22. PMID 23092753 DOI: 10.1016/j.ceb.2012.09.006  1
2012 Leduc C, Padberg-Gehle K, Varga V, Helbing D, Diez S, Howard J. [How to avoid the formation of molecular motors traffic jam during intracellular transport]. MéDecine Sciences : M/S. 28: 1064-6. PMID 23290405 DOI: 10.1051/medsci/20122812015  1
2012 Segal M, Soifer I, Petzold H, Howard J, Elbaum M, Reiner O. Ndel1-derived peptides modulate bidirectional transport of injected beads in the squid giant axon. Biology Open. 1: 220-31. PMID 23213412 DOI: 10.1242/bio.2012307  1
2012 Widlund PO, Podolski M, Reber S, Alper J, Storch M, Hyman AA, Howard J, Drechsel DN. One-step purification of assembly-competent tubulin from diverse eukaryotic sources. Molecular Biology of the Cell. 23: 4393-401. PMID 22993214 DOI: 10.1091/mbc.E12-06-0444  1
2012 Senthilan PR, Piepenbrock D, Ovezmyradov G, Nadrowski B, Bechstedt S, Pauls S, Winkler M, Möbius W, Howard J, Göpfert MC. Drosophila auditory organ genes and genetic hearing defects. Cell. 150: 1042-54. PMID 22939627 DOI: 10.1016/j.cell.2012.06.043  1
2012 Bormuth V, Nitzsche B, Ruhnow F, Mitra A, Storch M, Rammner B, Howard J, Diez S. The highly processive kinesin-8, Kip3, switches microtubule protofilaments with a bias toward the left. Biophysical Journal. 103: L4-6. PMID 22828351 DOI: 10.1016/j.bpj.2012.05.024  0.76
2012 Leduc C, Padberg-Gehle K, Varga V, Helbing D, Diez S, Howard J. Molecular crowding creates traffic jams of kinesin motors on microtubules. Proceedings of the National Academy of Sciences of the United States of America. 109: 6100-5. PMID 22431622 DOI: 10.1073/pnas.1107281109  1
2012 Tropini C, Roth EA, Zanic M, Gardner MK, Howard J. Islands containing slowly hydrolyzable GTP analogs promote microtubule rescues. Plos One. 7: e30103. PMID 22272281 DOI: 10.1371/journal.pone.0030103  1
2011 Gardner MK, Zanic M, Gell C, Bormuth V, Howard J. Depolymerizing kinesins Kip3 and MCAK shape cellular microtubule architecture by differential control of catastrophe. Cell. 147: 1092-103. PMID 22118464 DOI: 10.1016/j.cell.2011.10.037  1
2011 Mayr MI, Storch M, Howard J, Mayer TU. A non-motor microtubule binding site is essential for the high processivity and mitotic function of kinesin-8 Kif18A. Plos One. 6: e27471. PMID 22102900 DOI: 10.1371/journal.pone.0027471  0.36
2011 Alper J, Howard J. Hybrid four-headed myosin motor engineered with antagonistic motor domains. Proceedings of the National Academy of Sciences of the United States of America. 108: 15663-4. PMID 21900606 DOI: 10.1073/pnas.1112017108  1
2011 Gardner MK, Charlebois BD, Jánosi IM, Howard J, Hunt AJ, Odde DJ. Rapid microtubule self-assembly kinetics. Cell. 146: 582-92. PMID 21854983 DOI: 10.1016/j.cell.2011.06.053  1
2011 Bormuth V, Zörgibel F, Schäffer E, Howard J. Functional surface attachment in a sandwich geometry of GFP-labeled motor proteins. Methods in Molecular Biology (Clifton, N.J.). 778: 11-8. PMID 21809197 DOI: 10.1007/978-1-61779-261-8_2  0.76
2011 Gell C, Friel CT, Borgonovo B, Drechsel DN, Hyman AA, Howard J. Purification of tubulin from porcine brain. Methods in Molecular Biology (Clifton, N.J.). 777: 15-28. PMID 21773918 DOI: 10.1007/978-1-61779-252-6_2  1
2011 Howard J, Grill SW, Bois JS. Turing's next steps: the mechanochemical basis of morphogenesis. Nature Reviews. Molecular Cell Biology. 12: 392-8. PMID 21602907 DOI: 10.1038/nrm3120  1
2011 Widlund PO, Stear JH, Pozniakovsky A, Zanic M, Reber S, Brouhard GJ, Hyman AA, Howard J. XMAP215 polymerase activity is built by combining multiple tubulin-binding TOG domains and a basic lattice-binding region. Proceedings of the National Academy of Sciences of the United States of America. 108: 2741-6. PMID 21282620 DOI: 10.1073/pnas.1016498108  1
2010 Redemann S, Pecreaux J, Goehring NW, Khairy K, Stelzer EH, Hyman AA, Howard J. Membrane invaginations reveal cortical sites that pull on mitotic spindles in one-cell C. elegans embryos. Plos One. 5: e12301. PMID 20808841 DOI: 10.1371/journal.pone.0012301  1
2010 Nitzsche B, Bormuth V, Bräuer C, Howard J, Ionov L, Kerssemakers J, Korten T, Leduc C, Ruhnow F, Diez S. Studying kinesin motors by optical 3D-nanometry in gliding motility assays. Methods in Cell Biology. 95: 247-71. PMID 20466139 DOI: 10.1016/S0091-679X(10)95014-0  0.76
2010 Gell C, Bormuth V, Brouhard GJ, Cohen DN, Diez S, Friel CT, Helenius J, Nitzsche B, Petzold H, Ribbe J, Schäffer E, Stear JH, Trushko A, Varga V, Widlund PO, ... ... Howard J, et al. Microtubule dynamics reconstituted in vitro and imaged by single-molecule fluorescence microscopy. Methods in Cell Biology. 95: 221-45. PMID 20466138 DOI: 10.1016/S0091-679X(10)95013-9  1
2009 Zanic M, Stear JH, Hyman AA, Howard J. EB1 recognizes the nucleotide state of tubulin in the microtubule lattice. Plos One. 4: e7585. PMID 19851462 DOI: 10.1371/journal.pone.0007585  1
2009 Varga V, Leduc C, Bormuth V, Diez S, Howard J. Kinesin-8 motors act cooperatively to mediate length-dependent microtubule depolymerization. Cell. 138: 1174-83. PMID 19766569 DOI: 10.1016/j.cell.2009.07.032  1
2009 Bormuth V, Varga V, Howard J, Schäffer E. Protein friction limits diffusive and directed movements of kinesin motors on microtubules. Science (New York, N.Y.). 325: 870-3. PMID 19679813 DOI: 10.1126/science.1174923  1
2009 Howard J, Hyman AA. Growth, fluctuation and switching at microtubule plus ends. Nature Reviews. Molecular Cell Biology. 10: 569-74. PMID 19513082 DOI: 10.1038/nrm2713  1
2008 Bechstedt S, Howard J. Hearing mechanics: a fly in your ear. Current Biology : Cb. 18: R869-70. PMID 18812084 DOI: 10.1016/j.cub.2008.07.069  0.52
2008 Crevenna AH, Madathil S, Cohen DN, Wagenbach M, Fahmy K, Howard J. Secondary structure and compliance of a predicted flexible domain in kinesin-1 necessary for cooperation of motors. Biophysical Journal. 95: 5216-27. PMID 18775962 DOI: 10.1529/biophysj.108.132449  1
2008 Bormuth V, Jannasch A, Ander M, van Kats CM, van Blaaderen A, Howard J, Schäffer E. Optical trapping of coated microspheres. Optics Express. 16: 13831-44. PMID 18772994  0.76
2008 Brouhard GJ, Stear JH, Noetzel TL, Al-Bassam J, Kinoshita K, Harrison SC, Howard J, Hyman AA. XMAP215 is a processive microtubule polymerase. Cell. 132: 79-88. PMID 18191222 DOI: 10.1016/j.cell.2007.11.043  1
2007 Bechstedt S, Howard J. Models of hair cell mechanotransduction. Current Topics in Membranes. 59: 399-424. PMID 25168144 DOI: 10.1016/S1063-5823(06)59015-5  0.52
2007 Elie-Caille C, Severin F, Helenius J, Howard J, Muller DJ, Hyman AA. Straight GDP-tubulin protofilaments form in the presence of taxol. Current Biology : Cb. 17: 1765-70. PMID 17919908 DOI: 10.1016/j.cub.2007.08.063  0.44
2007 Bormuth V, Howard J, Schäffer E. LED illumination for video-enhanced DIC imaging of single microtubules. Journal of Microscopy. 226: 1-5. PMID 17381703 DOI: 10.1111/j.1365-2818.2007.01756.x  0.76
2007 Schäffer E, Nørrelykke SF, Howard J. Surface forces and drag coefficients of microspheres near a plane surface measured with optical tweezers. Langmuir : the Acs Journal of Surfaces and Colloids. 23: 3654-65. PMID 17326669 DOI: 10.1021/la0622368  0.76
2007 Howard J, Hyman AA. Microtubule polymerases and depolymerases. Current Opinion in Cell Biology. 19: 31-5. PMID 17184986 DOI: 10.1016/j.ceb.2006.12.009  0.44
2006 Pecreaux J, Röper JC, Kruse K, Jülicher F, Hyman AA, Grill SW, Howard J. Spindle oscillations during asymmetric cell division require a threshold number of active cortical force generators. Current Biology : Cb. 16: 2111-22. PMID 17084695 DOI: 10.1016/j.cub.2006.09.030  0.44
2006 Varga V, Helenius J, Tanaka K, Hyman AA, Tanaka TU, Howard J. Yeast kinesin-8 depolymerizes microtubules in a length-dependent manner. Nature Cell Biology. 8: 957-62. PMID 16906145 DOI: 10.1038/ncb1462  1
2005 Poole K, Khairy K, Friedrichs J, Franz C, Cisneros DA, Howard J, Mueller D. Molecular-scale topographic cues induce the orientation and directional movement of fibroblasts on two-dimensional collagen surfaces. Journal of Molecular Biology. 349: 380-6. PMID 15890202 DOI: 10.1016/j.jmb.2005.03.064  1
2004 Jiang F, Khairy K, Poole K, Howard J, Müller DJ. Creating nanoscopic collagen matrices using atomic force microscopy. Microscopy Research and Technique. 64: 435-40. PMID 15549696 DOI: 10.1002/jemt.20101  1
2004 Lawrence CJ, Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA, Goldstein LS, Goodson HV, Hirokawa N, Howard J, Malmberg RL, McIntosh JR, Miki H, Mitchison TJ, Okada Y, et al. A standardized kinesin nomenclature. The Journal of Cell Biology. 167: 19-22. PMID 15479732 DOI: 10.1083/jcb.200408113  1
2004 Haeberle H, Fujiwara M, Chuang J, Medina MM, Panditrao MV, Bechstedt S, Howard J, Lumpkin EA. Molecular profiling reveals synaptic release machinery in Merkel cells. Proceedings of the National Academy of Sciences of the United States of America. 101: 14503-8. PMID 15448211 DOI: 10.1073/pnas.0406308101  1
2004 Sawhney RK, Howard J. Molecular dissection of the fibroblast-traction machinery. Cell Motility and the Cytoskeleton. 58: 175-85. PMID 15146536 DOI: 10.1002/cm.20004  1
2004 Howard J, Bechstedt S. Hypothesis: a helix of ankyrin repeats of the NOMPC-TRP ion channel is the gating spring of mechanoreceptors. Current Biology : Cb. 14: R224-6. PMID 15043829 DOI: 10.1016/j.cub.2004.02.050  0.52
2003 Grill SW, Howard J, Schäffer E, Stelzer EH, Hyman AA. The distribution of active force generators controls mitotic spindle position. Science (New York, N.Y.). 301: 518-21. PMID 12881570 DOI: 10.1126/science.1086560  0.76
2002 Sawhney RK, Howard J. Slow local movements of collagen fibers by fibroblasts drive the rapid global self-organization of collagen gels. The Journal of Cell Biology. 157: 1083-91. PMID 12058022 DOI: 10.1083/jcb.200203069  1
2002 Vinh DB, Kern JW, Hancock WO, Howard J, Davis TN. Reconstitution and characterization of budding yeast gamma-tubulin complex. Molecular Biology of the Cell. 13: 1144-57. PMID 11950928 DOI: 10.1091/mbc.02-01-0607  1
1994 Hunt AJ, Gittes F, Howard J. The force exerted by a single kinesin molecule against a viscous load. Biophysical Journal. 67: 766-81. PMID 7948690 DOI: 10.1016/S0006-3495(94)80537-5  1
1993 Hunt AJ, Howard J. Kinesin swivels to permit microtubule movement in any direction. Proceedings of the National Academy of Sciences of the United States of America. 90: 11653-7. PMID 8265603  1
1993 Howard J, Hunt AJ, Baek S. Assay of microtubule movement driven by single kinesin molecules. Methods in Cell Biology. 39: 137-47. PMID 8246794  1
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