Hans A. Kretzschmar - Publications

Affiliations: 
Neuropathology Georg-August-Universität Göttingen, Göttingen, Niedersachsen, Germany 
Area:
neurodegeneration, prions, neuropathology

304 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Wagner M, Steinbacher J, Kraus TF, Michalakis S, Hackner B, Pfaffeneder T, Perera A, Müller M, Giese A, Kretzschmar HA, Carell T. Age-Dependent Levels of 5-Methyl-, 5-Hydroxymethyl-, and 5-Formylcytosine in Human and Mouse Brain Tissues. Angewandte Chemie (International Ed. in English). PMID 26137924 DOI: 10.1002/anie.201502722  0.32
2015 Kouri N, Ross OA, Dombroski B, Younkin CS, Serie DJ, Soto-Ortolaza A, Baker M, Finch NC, Yoon H, Kim J, Fujioka S, McLean CA, Ghetti B, Spina S, Cantwell LB, ... ... Kretzschmar HA, et al. Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy. Nature Communications. 6: 7247. PMID 26077951 DOI: 10.1038/ncomms8247  0.32
2015 Krasnianski A, Heinemann U, Ponto C, Kortt J, Kallenberg K, Varges D, Schulz-Schaeffer WJ, Kretzschmar HA, Zerr I. Clinical findings and diagnosis in genetic prion diseases in Germany. European Journal of Epidemiology. PMID 26076917 DOI: 10.1007/s10654-015-0049-y  0.32
2015 Suchorska B, Jansen NL, Linn J, Kretzschmar H, Janssen H, Eigenbrod S, Simon M, Pöpperl G, Kreth FW, la Fougere C, Weller M, Tonn JC. Biological tumor volume in 18FET-PET before radiochemotherapy correlates with survival in GBM. Neurology. 84: 710-9. PMID 25609769 DOI: 10.1212/WNL.0000000000001262  0.32
2015 Schulte EC, Fukumori A, Mollenhauer B, Hor H, Arzberger T, Perneczky R, Kurz A, Diehl-Schmid J, Hüll M, Lichtner P, Eckstein G, Zimprich A, Haubenberger D, Pirker W, Brücke T, ... ... Kretzschmar HA, et al. Rare variants in β-Amyloid precursor protein (APP) and Parkinson's disease. European Journal of Human Genetics : Ejhg. PMID 25604855 DOI: 10.1038/ejhg.2014.300  0.32
2015 Durrenberger PF, Fernando FS, Kashefi SN, Bonnert TP, Seilhean D, Nait-Oumesmar B, Schmitt A, Gebicke-Haerter PJ, Falkai P, Grünblatt E, Palkovits M, Arzberger T, Kretzschmar H, Dexter DT, Reynolds R. Common mechanisms in neurodegeneration and neuroinflammation: a BrainNet Europe gene expression microarray study. Journal of Neural Transmission (Vienna, Austria : 1996). 122: 1055-68. PMID 25119539 DOI: 10.1007/s00702-014-1293-0  0.32
2015 Pöschl J, Berger F, Kretzschmar H, Schüller U. A 59-Year-Old Man with Two Cerebellar Lesions and Disturbed Cerebellar Morphology Brain Pathology. 25: 790-791. DOI: 10.1111/bpa.12322  0.32
2014 Slattery CF, Beck JA, Harper L, Adamson G, Abdi Z, Uphill J, Campbell T, Druyeh R, Mahoney CJ, Rohrer JD, Kenny J, Lowe J, Leung KK, Barnes J, Clegg SL, ... ... Kretzschmar H, et al. R47H TREM2 variant increases risk of typical early-onset Alzheimer's disease but not of prion or frontotemporal dementia. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: 602-608.e4. PMID 25160042 DOI: 10.1016/j.jalz.2014.05.1751  0.32
2014 Krasnianski A, Kaune J, Jung K, Kretzschmar HA, Zerr I. First symptom and initial diagnosis in sporadic CJD patients in Germany. Journal of Neurology. 261: 1811-7. PMID 25022936 DOI: 10.1007/s00415-014-7410-z  0.32
2014 Banzhaf-Strathmann J, Benito E, May S, Arzberger T, Tahirovic S, Kretzschmar H, Fischer A, Edbauer D. MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease. The Embo Journal. 33: 1667-80. PMID 25001178 DOI: 10.15252/embj.201387576  0.32
2014 Levin J, Tiedt S, Arzberger T, Biskup S, Schuberth M, Stenglein-Krapf G, Kreth FW, Högen T, la Fougère C, Linn J, van der Knaap MS, Giese A, Kretzschmar HA, Danek A. Diffuse leukoencephalopathy with spheroids: biopsy findings and a novel mutation. Clinical Neurology and Neurosurgery. 122: 113-5. PMID 24908228 DOI: 10.1016/j.clineuro.2014.04.022  0.32
2014 Tian C, Liu D, Xiang W, Kretzschmar HA, Sun QL, Gao C, Xu Y, Wang H, Fan XY, Meng G, Li W, Dong XP. Analyses of the similarity and difference of global gene expression profiles in cortex regions of three neurodegenerative diseases: sporadic Creutzfeldt-Jakob disease (sCJD), fatal familial insomnia (FFI), and Alzheimer's disease (AD). Molecular Neurobiology. 50: 473-81. PMID 24902808 DOI: 10.1007/s12035-014-8758-x  0.32
2014 Eigenbrod S, Trabold R, Brucker D, Erös C, Egensperger R, La Fougere C, Göbel W, Rühm A, Kretzschmar HA, Tonn JC, Herms J, Giese A, Kreth FW. Molecular stereotactic biopsy technique improves diagnostic accuracy and enables personalized treatment strategies in glioma patients. Acta Neurochirurgica. 156: 1427-40. PMID 24792966 DOI: 10.1007/s00701-014-2073-1  0.32
2014 Schuberth M, Levin J, Sawalhe D, Schwarzkopf R, von Baumgarten L, Ertl-Wagner B, Rominger A, Arzberger T, Kretzschmar HA, Froböse T, Diehl-Schmid J, Biskup S, Danek A. [Hereditary diffuse leukencephalopathy with spheroids: a microgliopathy due to CSF1 receptor impairment]. Der Nervenarzt. 85: 465-70. PMID 24706185 DOI: 10.1007/s00115-014-4052-4  0.32
2014 Götzl JK, Mori K, Damme M, Fellerer K, Tahirovic S, Kleinberger G, Janssens J, van der Zee J, Lang CM, Kremmer E, Martin JJ, Engelborghs S, Kretzschmar HA, Arzberger T, Van Broeckhoven C, et al. Common pathobiochemical hallmarks of progranulin-associated frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis. Acta Neuropathologica. 127: 845-60. PMID 24619111 DOI: 10.1007/s00401-014-1262-6  0.32
2014 Leidel F, Eiden M, Geissen M, Hirschberger T, Tavan P, Giese A, Kretzschmar HA, Schätzl H, Groschup MH. Piperazine derivatives inhibit PrP/PrP(res) propagation in vitro and in vivo. Biochemical and Biophysical Research Communications. 445: 23-9. PMID 24502948 DOI: 10.1016/j.bbrc.2014.01.122  0.32
2014 Rachinger W, Eigenbrod S, Dützmann S, Simon M, Feigl GC, Kremenevskaja N, Kretzschmar H, Zausinger S, Kreth FW, Thon N, Tonn JC. Male sex as a risk factor for the clinical course of skull base chordomas. Journal of Neurosurgery. 120: 1313-20. PMID 24405075 DOI: 10.3171/2013.11.JNS131137  0.32
2014 Sellmann C, Villarín Pildaín L, Schmitt A, Leonardi-Essmann F, Durrenberger PF, Spanagel R, Arzberger T, Kretzschmar H, Zink M, Gruber O, Herrera-Marschitz M, Reynolds R, Falkai P, Gebicke-Haerter PJ, Matthäus F. Gene expression in superior temporal cortex of schizophrenia patients. European Archives of Psychiatry and Clinical Neuroscience. 264: 297-309. PMID 24287731 DOI: 10.1007/s00406-013-0473-5  0.32
2014 Krasnianski A, Sanchez Juan P, Ponto C, Bartl M, Heinemann U, Varges D, Schulz-Schaeffer WJ, Kretzschmar HA, Zerr I. A proposal of new diagnostic pathway for fatal familial insomnia. Journal of Neurology, Neurosurgery, and Psychiatry. 85: 654-9. PMID 24249784 DOI: 10.1136/jnnp-2013-305978  0.32
2014 Craggs LJ, Yamamoto Y, Ihara M, Fenwick R, Burke M, Oakley AE, Roeber S, Duering M, Kretzschmar H, Kalaria RN. White matter pathology and disconnection in the frontal lobe in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Neuropathology and Applied Neurobiology. 40: 591-602. PMID 23844775 DOI: 10.1111/nan.12073  0.32
2013 Shi S, Mitteregger-Kretzschmar G, Giese A, Kretzschmar HA. Establishing quantitative real-time quaking-induced conversion (qRT-QuIC) for highly sensitive detection and quantification of PrPSc in prion-infected tissues. Acta Neuropathologica Communications. 1: 44. PMID 24252329 DOI: 10.1186/2051-5960-1-44  0.32
2013 Mori K, Arzberger T, Grässer FA, Gijselinck I, May S, Rentzsch K, Weng SM, Schludi MH, van der Zee J, Cruts M, Van Broeckhoven C, Kremmer E, Kretzschmar HA, Haass C, Edbauer D. Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins. Acta Neuropathologica. 126: 881-93. PMID 24132570 DOI: 10.1007/s00401-013-1189-3  0.32
2013 Mackenzie IR, Arzberger T, Kremmer E, Troost D, Lorenzl S, Mori K, Weng SM, Haass C, Kretzschmar HA, Edbauer D, Neumann M. Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations. Acta Neuropathologica. 126: 859-79. PMID 24096617 DOI: 10.1007/s00401-013-1181-y  0.32
2013 Kastrup O, Göricke S, Kretzschmar H, Wauschkuhn B, Diener HC. Progressive multifocal leukoencephalopathy of the brainstem in an immunocompetent patient - JC and BK polyoma-virus coinfection? A case report and review of the literature Clinical Neurology and Neurosurgery. 115: 2390-2392. PMID 24094671 DOI: 10.1016/j.clineuro.2013.08.021  0.32
2013 Samarasekera N, Al-Shahi Salman R, Huitinga I, Klioueva N, McLean CA, Kretzschmar H, Smith C, Ironside JW. Brain banking for neurological disorders. The Lancet. Neurology. 12: 1096-105. PMID 24074724 DOI: 10.1016/S1474-4422(13)70202-3  0.32
2013 Bernhardt A, de Boni L, Kretzschmar HA, Tintelnot K. [Molecular biological identification of fungal pathogens in FFPE tissue from cases of cephalic mycosis]. Der Pathologe. 34: 540-7. PMID 24043212 DOI: 10.1007/s00292-013-1833-7  0.32
2013 Saverioni D, Notari S, Capellari S, Poggiolini I, Giese A, Kretzschmar HA, Parchi P. Analyses of protease resistance and aggregation state of abnormal prion protein across the spectrum of human prions. The Journal of Biological Chemistry. 288: 27972-85. PMID 23897825 DOI: 10.1074/jbc.M113.477547  0.32
2013 Wagner J, Ryazanov S, Leonov A, Levin J, Shi S, Schmidt F, Prix C, Pan-Montojo F, Bertsch U, Mitteregger-Kretzschmar G, Geissen M, Eiden M, Leidel F, Hirschberger T, Deeg AA, ... ... Kretzschmar H, et al. Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease. Acta Neuropathologica. 125: 795-813. PMID 23604588 DOI: 10.1007/s00401-013-1114-9  0.32
2013 Ahlfeld J, Favaro R, Pagella P, Kretzschmar HA, Nicolis S, Schüller U. Sox2 requirement in sonic hedgehog-associated medulloblastoma. Cancer Research. 73: 3796-807. PMID 23596255 DOI: 10.1158/0008-5472.CAN-13-0238  0.32
2013 Kretzschmar H, Tatzelt J. Prion disease: A tale of folds and strains Brain Pathology. 23: 321-332. PMID 23587138 DOI: 10.1111/bpa.12045  0.32
2013 Steinacker P, Weidehaas K, Cepek L, Feneberg E, Kretzschmar HA, Otto M. Influence of the blood-CSF-barrier function on S100B in neurodegenerative diseases. Acta Neurologica Scandinavica. 128: 249-56. PMID 23510454 DOI: 10.1111/ane.12113  0.32
2013 Schelzke G, Stoeck K, Eigenbrod S, Grasbon-Frodl E, Raddatz LM, Ponto C, Kretzschmar HA, Zerr I. Report about four novel mutations in the prion protein gene. Dementia and Geriatric Cognitive Disorders. 35: 229-37. PMID 23467330 DOI: 10.1159/000345991  0.32
2013 Respondek G, Roeber S, Kretzschmar H, Troakes C, Al-Sarraj S, Gelpi E, Gaig C, Chiu WZ, van Swieten JC, Oertel WH, Höglinger GU. Accuracy of the National Institute for Neurological Disorders and Stroke/Society for Progressive Supranuclear Palsy and neuroprotection and natural history in Parkinson plus syndromes criteria for the diagnosis of progressive supranuclear palsy. Movement Disorders : Official Journal of the Movement Disorder Society. 28: 504-9. PMID 23436751 DOI: 10.1002/mds.25327  0.32
2013 Plate A, Benninghoff J, Jansen GH, Wlasich E, Eigenbrod S, Drzezga A, Jansen NL, Kretzschmar HA, Bötzel K, Rujescu D, Danek A. Atypical parkinsonism due to a D202N Gerstmann-Sträussler-Scheinker prion protein mutation: first in vivo diagnosed case. Movement Disorders : Official Journal of the Movement Disorder Society. 28: 241-4. PMID 23436635 DOI: 10.1002/mds.25188  0.32
2013 Tian C, Liu D, Sun QL, Chen C, Xu Y, Wang H, Xiang W, Kretzschmar HA, Li W, Chen C, Shi Q, Gao C, Zhang J, Zhang BY, Han J, et al. Comparative analysis of gene expression profiles between cortex and thalamus in Chinese fatal familial insomnia patients. Molecular Neurobiology. 48: 36-48. PMID 23430483 DOI: 10.1007/s12035-013-8426-6  0.32
2013 Mori K, Weng SM, Arzberger T, May S, Rentzsch K, Kremmer E, Schmid B, Kretzschmar HA, Cruts M, Van Broeckhoven C, Haass C, Edbauer D. The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS. Science (New York, N.Y.). 339: 1335-8. PMID 23393093 DOI: 10.1126/science.1232927  0.32
2013 Mori K, Lammich S, Mackenzie IR, Forné I, Zilow S, Kretzschmar H, Edbauer D, Janssens J, Kleinberger G, Cruts M, Herms J, Neumann M, Van Broeckhoven C, Arzberger T, Haass C. hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations. Acta Neuropathologica. 125: 413-23. PMID 23381195 DOI: 10.1007/s00401-013-1088-7  0.32
2013 Honarnejad K, Jung CKE, Lammich S, Arzberger T, Kretzschmar H, Herms J. Involvement of presenilin holoprotein upregulation in calcium dyshomeostasis of Alzheimer's disease Journal of Cellular and Molecular Medicine. 17: 293-302. PMID 23379308 DOI: 10.1111/jcmm.12008  0.32
2013 Pöschl J, Grammel D, Dorostkar MM, Kretzschmar HA, Schüller U. Constitutive activation of β-catenin in neural progenitors results in disrupted proliferation and migration of neurons within the central nervous system. Developmental Biology. 374: 319-32. PMID 23237957 DOI: 10.1016/j.ydbio.2012.12.001  0.32
2013 Marek M, Klockgether T, Urbach H, Zerr I, Kretzschmar H, Paus S. Isolated spasticity in sporadic Creutzfeldt-Jakob disease Journal of Neurology. 260: 654-655. PMID 23161461 DOI: 10.1007/s00415-012-6746-5  0.32
2013 Sanin V, Heeß C, Kretzschmar HA, Schüller U. Recruitment of neural precursor cells from circumventricular organs of patients with cerebral ischaemia. Neuropathology and Applied Neurobiology. 39: 510-8. PMID 22985410 DOI: 10.1111/j.1365-2990.2012.01301.x  0.32
2013 Kovacs GG, Rozemuller AJ, van Swieten JC, Gelpi E, Majtenyi K, Al-Sarraj S, Troakes C, Bódi I, King A, Hortobágyi T, Esiri MM, Ansorge O, Giaccone G, Ferrer I, Arzberger T, ... ... Kretzschmar H, et al. Neuropathology of the hippocampus in FTLD-Tau with Pick bodies: a study of the BrainNet Europe Consortium. Neuropathology and Applied Neurobiology. 39: 166-78. PMID 22471883 DOI: 10.1111/j.1365-2990.2012.01272.x  0.32
2013 Breithaupt M, Romero C, Kallenberg K, Begue C, Sanchez-Juan P, Eigenbrod S, Kretzschmar H, Schelzke G, Meichtry E, Taratuto A, Zerr I. Magnetic resonance imaging in E200K and V210I mutations of the prion protein gene. Alzheimer Disease and Associated Disorders. 27: 87-90. PMID 22407223 DOI: 10.1097/WAD.0b013e31824d578a  0.32
2012 Schön C, Hoffmann NA, Ochs SM, Burgold S, Filser S, Steinbach S, Seeliger MW, Arzberger T, Goedert M, Kretzschmar HA, Schmidt B, Herms J. Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice. Plos One. 7: e53547. PMID 23300938 DOI: 10.1371/journal.pone.0053547  0.32
2012 Jesse S, Lehnert S, Jahn O, Parnetti L, Soininen H, Herukka SK, Steinacker P, Tawfik S, Tumani H, von Arnim CA, Neumann M, Kretzschmar HA, Kulaksiz H, Lenter M, Wiltfang J, et al. Differential sialylation of serpin A1 in the early diagnosis of Parkinson's disease dementia. Plos One. 7: e48783. PMID 23144969 DOI: 10.1371/journal.pone.0048783  0.32
2012 Jansen NL, Schwartz C, Graute V, Eigenbrod S, Lutz J, Egensperger R, Pöpperl G, Kretzschmar HA, Cumming P, Bartenstein P, Tonn JC, Kreth FW, la Fougère C, Thon N. Prediction of oligodendroglial histology and LOH 1p/19q using dynamic [(18)F]FET-PET imaging in intracranial WHO grade II and III gliomas. Neuro-Oncology. 14: 1473-80. PMID 23090986 DOI: 10.1093/neuonc/nos259  0.32
2012 Schankin CJ, Reifferscheid AK, Krumbholz M, Linn J, Rachinger W, Langer S, Sostak P, Arzberger T, Kretzschmar H, Straube A. Headache in patients with pituitary adenoma: clinical and paraclinical findings. Cephalalgia : An International Journal of Headache. 32: 1198-207. PMID 23059488 DOI: 10.1177/0333102412462639  0.32
2012 Bittner T, Burgold S, Dorostkar MM, Fuhrmann M, Wegenast-Braun BM, Schmidt B, Kretzschmar H, Herms J. Amyloid plaque formation precedes dendritic spine loss Acta Neuropathologica. 124: 797-807. PMID 22993126 DOI: 10.1007/s00401-012-1047-8  0.32
2012 Schmidt F, Levin J, Kamp F, Kretzschmar H, Giese A, Bötzel K. Single-channel electrophysiology reveals a distinct and uniform pore complex formed by α-synuclein oligomers in lipid membranes Plos One. 7. PMID 22880029 DOI: 10.1371/journal.pone.0042545  0.32
2012 Durrenberger PF, Fernando FS, Magliozzi R, Kashefi SN, Bonnert TP, Ferrer I, Seilhean D, Nait-Oumesmar B, Schmitt A, Gebicke-Haerter PJ, Falkai P, Grünblatt E, Palkovits M, Parchi P, Capellari S, ... ... Kretzschmar H, et al. Selection of novel reference genes for use in the human central nervous system: a BrainNet Europe Study. Acta Neuropathologica. 124: 893-903. PMID 22864814 DOI: 10.1007/s00401-012-1027-z  0.32
2012 Neumann M, Valori CF, Ansorge O, Kretzschmar HA, Munoz DG, Kusaka H, Yokota O, Ishihara K, Ang LC, Bilbao JM, Mackenzie IR. Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations. Acta Neuropathologica. 124: 705-16. PMID 22842875 DOI: 10.1007/s00401-012-1020-6  0.32
2012 Rutherford NJ, Heckman MG, Dejesus-Hernandez M, Baker MC, Soto-Ortolaza AI, Rayaprolu S, Stewart H, Finger E, Volkening K, Seeley WW, Hatanpaa KJ, Lomen-Hoerth C, Kertesz A, Bigio EH, Lippa C, ... ... Kretzschmar HA, et al. Length of normal alleles of C9ORF72 GGGGCC repeat do not influence disease phenotype. Neurobiology of Aging. 33: 2950.e5-7. PMID 22840558 DOI: 10.1016/j.neurobiolaging.2012.07.005  0.32
2012 Nübling G, Bader B, Levin J, Hildebrandt J, Kretzschmar H, Giese A. Synergistic influence of phosphorylation and metal ions on tau oligomer formation and coaggregation with α-synuclein at the single molecule level Molecular Neurodegeneration. 7. PMID 22824345 DOI: 10.1186/1750-1326-7-35  0.32
2012 Fiorino F, Eiden M, Giese A, Severino B, Esposito A, Groschup MH, Perissutti E, Magli E, Incisivo GM, Ciano A, Frecentese F, Kretzschmar HA, Wagner J, Santagada V, Caliendo G. Synthesis of benzamide derivatives and their evaluation as antiprion agents. Bioorganic & Medicinal Chemistry. 20: 5001-11. PMID 22795751 DOI: 10.1016/j.bmc.2012.06.026  0.32
2012 Parchi P, de Boni L, Saverioni D, Cohen ML, Ferrer I, Gambetti P, Gelpi E, Giaccone G, Hauw JJ, Höftberger R, Ironside JW, Jansen C, Kovacs GG, Rozemuller A, Seilhean D, ... ... Kretzschmar HA, et al. Consensus classification of human prion disease histotypes allows reliable identification of molecular subtypes: an inter-rater study among surveillance centres in Europe and USA. Acta Neuropathologica. 124: 517-29. PMID 22744790 DOI: 10.1007/s00401-012-1002-8  0.32
2012 Ottis P, Koppe K, Onisko B, Dynin I, Arzberger T, Kretzschmar H, Requena JR, Silva CJ, Huston JP, Korth C. Human and rat brain lipofuscin proteome. Proteomics. 12: 2445-54. PMID 22707227 DOI: 10.1002/pmic.201100668  0.32
2012 Alafuzoff I, Gelpi E, Al-Sarraj S, Arzberger T, Attems J, Bodi I, Bogdanovic N, Budka H, Bugiani O, Englund E, Ferrer I, Gentleman S, Giaccone G, Graeber MB, Hortobagyi T, ... ... Kretzschmar H, et al. The need to unify neuropathological assessments of vascular alterations in the ageing brain: multicentre survey by the BrainNet Europe consortium. Experimental Gerontology. 47: 825-33. PMID 22705312 DOI: 10.1016/j.exger.2012.06.001  0.32
2012 Högen T, Levin J, Schmidt F, Caruana M, Vassallo N, Kretzschmar H, Bötzel K, Kamp F, Giese A. Two different binding modes of α-synuclein to lipid vesicles depending on its aggregation state Biophysical Journal. 102: 1646-1655. PMID 22500765 DOI: 10.1016/j.bpj.2012.01.059  0.32
2012 Schmidt C, Haïk S, Satoh K, Rábano A, Martinez-Martin P, Roeber S, Brandel JP, Calero-Lara M, de Pedro-Cuesta J, Laplanche JL, Hauw JJ, Kretzschmar H, Zerr I. Rapidly progressive Alzheimer's disease: a multicenter update. Journal of Alzheimer's Disease : Jad. 30: 751-6. PMID 22460329 DOI: 10.3233/JAD-2012-120007  0.32
2012 Schmitt A, Leonardi-Essmann F, Durrenberger PF, Wichert SP, Spanagel R, Arzberger T, Kretzschmar H, Zink M, Herrera-Marschitz M, Reynolds R, Rossner MJ, Falkai P, Gebicke-Haerter PJ. Structural synaptic elements are differentially regulated in superior temporal cortex of schizophrenia patients. European Archives of Psychiatry and Clinical Neuroscience. 262: 565-77. PMID 22441714 DOI: 10.1007/s00406-012-0306-y  0.32
2012 Adam SA, Schnell O, Pöschl J, Eigenbrod S, Kretzschmar HA, Tonn JC, Schüller U. ALDH1A1 is a marker of astrocytic differentiation during brain development and correlates with better survival in glioblastoma patients. Brain Pathology (Zurich, Switzerland). 22: 788-97. PMID 22417385 DOI: 10.1111/j.1750-3639.2012.00592.x  0.32
2012 Oeckl P, Steinacker P, Lehnert S, Jesse S, Kretzschmar HA, Ludolph AC, Otto M, Ferger B. CSF concentrations of cAMP and cGMP are lower in patients with Creutzfeldt-Jakob disease but not Parkinson's disease and amyotrophic lateral sclerosis. Plos One. 7: e32664. PMID 22396786 DOI: 10.1371/journal.pone.0032664  0.32
2012 Schelzke G, Kretzschmar HA, Zerr I. Clinical aspects of common genetic Creutzfeldt-Jakob disease. European Journal of Epidemiology. 27: 147-9. PMID 22382354 DOI: 10.1007/s10654-012-9660-3  0.32
2012 Frick A, Grammel D, Schmidt F, Pöschl J, Priller M, Pagella P, von Bueren AO, Peraud A, Tonn JC, Herms J, Rutkowski S, Kretzschmar HA, Schüller U. Proper cerebellar development requires expression of β1-integrin in Bergmann glia, but not in granule neurons. Glia. 60: 820-32. PMID 22374686 DOI: 10.1002/glia.22314  0.32
2012 Martins-de-Souza D, Guest PC, Mann DM, Roeber S, Rahmoune H, Bauder C, Kretzschmar H, Volk B, Baborie A, Bahn S. Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. Journal of Proteome Research. 11: 2533-43. PMID 22360420 DOI: 10.1021/pr2012279  0.32
2012 Grammel D, Warmuth-Metz M, von Bueren AO, Kool M, Pietsch T, Kretzschmar HA, Rowitch DH, Rutkowski S, Pfister SM, Schüller U. Sonic hedgehog-associated medulloblastoma arising from the cochlear nuclei of the brainstem. Acta Neuropathologica. 123: 601-14. PMID 22349907 DOI: 10.1007/s00401-012-0961-0  0.32
2012 Kraus TF, Globisch D, Wagner M, Eigenbrod S, Widmann D, Münzel M, Müller M, Pfaffeneder T, Hackner B, Feiden W, Schüller U, Carell T, Kretzschmar HA. Low values of 5-hydroxymethylcytosine (5hmC), the "sixth base," are associated with anaplasia in human brain tumors. International Journal of Cancer. Journal International Du Cancer. 131: 1577-90. PMID 22234893 DOI: 10.1002/ijc.27429  0.32
2012 Mead S, Uphill J, Beck J, Poulter M, Campbell T, Lowe J, Adamson G, Hummerich H, Klopp N, Rückert IM, Wichmann HE, Azazi D, Plagnol V, Pako WH, Whitfield J, ... ... Kretzschmar H, et al. Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP. Human Molecular Genetics. 21: 1897-906. PMID 22210626 DOI: 10.1093/hmg/ddr607  0.32
2012 Rademakers R, Baker M, Nicholson AM, Rutherford NJ, Finch N, Soto-Ortolaza A, Lash J, Wider C, Wojtas A, DeJesus-Hernandez M, Adamson J, Kouri N, Sundal C, Shuster EA, Aasly J, ... ... Kretzschmar HA, et al. Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids. Nature Genetics. 44: 200-5. PMID 22197934 DOI: 10.1038/ng.1027  0.32
2012 Martins-de-Souza D, Guest PC, Guest FL, Bauder C, Rahmoune H, Pietsch S, Roeber S, Kretzschmar H, Mann D, Baborie A, Bahn S. Characterization of the human primary visual cortex and cerebellum proteomes using shotgun mass spectrometry-data-independent analyses. Proteomics. 12: 500-4. PMID 22162416 DOI: 10.1002/pmic.201100476  0.32
2012 Sanchez-Juan P, Bishop MT, Aulchenko YS, Brandel JP, Rivadeneira F, Struchalin M, Lambert JC, Amouyel P, Combarros O, Sainz J, Carracedo A, Uitterlinden AG, Hofman A, Zerr I, Kretzschmar HA, et al. Genome-wide study links MTMR7 gene to variant Creutzfeldt-Jakob risk. Neurobiology of Aging. 33: 1487.e21-8. PMID 22137330 DOI: 10.1016/j.neurobiolaging.2011.10.011  0.32
2012 Hokkanen S, Feldmann HM, Ding H, Jung CKE, Bojarski L, ller IRM, Schüller U, Kretzschmar H, Wolf E, Herms J. Lack of pur-alpha alters postnatal brain development and causes megalencephaly Human Molecular Genetics. 21: 473-484. PMID 22010047 DOI: 10.1093/hmg/ddr476  0.32
2012 Thon N, Eigenbrod S, Kreth S, Lutz J, Tonn JC, Kretzschmar H, Peraud A, Kreth FW. IDH1 mutations in grade II astrocytomas are associated with unfavorable progression-free survival and prolonged postrecurrence survival Cancer. 118: 452-460. PMID 21717448 DOI: 10.1002/cncr.26298  0.32
2012 Bartels S, de Boni L, Kretzschmar HA, Heckmann JG. Lethal encephalitis caused by the Toscana virus in an elderly patient. Journal of Neurology. 259: 175-7. PMID 21656341 DOI: 10.1007/s00415-011-6121-y  0.32
2012 Schnell O, Romagna A, Jaehnert I, Albrecht V, Eigenbrod S, Juerchott K, Kretzschmar H, Tonn JC, Schichor C. Krüppel-like factor 8 (KLF8) is expressed in gliomas of different WHO grades and is essential for tumor cell proliferation Plos One. 7. DOI: 10.1371/journal.pone.0030429  0.32
2011 Levin J, Högen T, Hillmer AS, Bader B, Schmidt F, Kamp F, Kretzschmar HA, Bötzel K, Giese A. Generation of ferric iron links oxidative stress to α-synuclein oligomer formation. Journal of Parkinson's Disease. 1: 205-16. PMID 23934922 DOI: 10.3233/JPD-2011-11040  0.32
2011 Niyazi M, Zehentmayr F, Niemöller OM, Eigenbrod S, Kretzschmar H, Osthoff KS, Tonn JC, Atkinson M, Mörtl S, Belka C. MiRNA expression patterns predict survival in glioblastoma Radiation Oncology. 6. PMID 22074483 DOI: 10.1186/1748-717X-6-153  0.32
2011 Roos KL, Gerdes LA, Kurz K, Kretzschmar H, Kümpfel T, Parisi JE, Keegan BM. An enhancing brainstem lesion in a patient with a history of worldwide travel. Neurology. 77: 1756-60. PMID 22067962 DOI: 10.1212/WNL.0b013e318236eec2  0.32
2011 de Boni L, Tierling S, Roeber S, Walter J, Giese A, Kretzschmar HA. Next-generation sequencing reveals regional differences of the α-synuclein methylation state independent of Lewy body disease. Neuromolecular Medicine. 13: 310-20. PMID 22042430 DOI: 10.1007/s12017-011-8163-9  0.32
2011 Eigenbrod S, Roeber S, Thon N, Giese A, Krieger A, Grasbon-Frodl E, Egensperger R, Tonn JC, Kreth FW, Kretzschmar HA. α-Internexin in the diagnosis of oligodendroglial tumors and association with 1p/19q status. Journal of Neuropathology and Experimental Neurology. 70: 970-8. PMID 22002423 DOI: 10.1097/NEN.0b013e3182333ef5  0.32
2011 Hartig MB, Iuso A, Haack T, Kmiec T, Jurkiewicz E, Heim K, Roeber S, Tarabin V, Dusi S, Krajewska-Walasek M, Jozwiak S, Hempel M, Winkelmann J, Elstner M, Oexle K, ... ... Kretzschmar H, et al. Absence of an orphan mitochondrial protein, C19orf12, causes a distinct clinical subtype of neurodegeneration with brain iron accumulation American Journal of Human Genetics. 89: 543-550. PMID 21981780 DOI: 10.1016/j.ajhg.2011.09.007  0.32
2011 Priller M, Pöschl J, Abrão L, von Bueren AO, Cho YJ, Rutkowski S, Kretzschmar HA, Schüller U. Expression of FoxM1 is required for the proliferation of medulloblastoma cells and indicates worse survival of patients. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 6791-801. PMID 21918172 DOI: 10.1158/1078-0432.CCR-11-1214  0.32
2011 Neumann M, Bentmann E, Dormann D, Jawaid A, DeJesus-Hernandez M, Ansorge O, Roeber S, Kretzschmar HA, Munoz DG, Kusaka H, Yokota O, Ang LC, Bilbao J, Rademakers R, Haass C, et al. FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations. Brain : a Journal of Neurology. 134: 2595-609. PMID 21856723 DOI: 10.1093/brain/awr201  0.32
2011 Otto M, Ludolph AC, Landwehrmeyer B, Förstl H, Diehl-Schmid J, Neumann M, Kretzschmar HA, Schroeter M, Kornhuber J, Danek A. [German consortium for frontotemporal lobar degeneration]. Der Nervenarzt. 82: 1002-5. PMID 21805118 DOI: 10.1007/s00115-011-3261-3  0.32
2011 Geissen M, Leidel F, Eiden M, Hirschberger T, Fast C, Bertsch U, Tavan P, Giese A, Kretzschmar H, Schatzl HM, Groschup MH. From High-Throughput Cell Culture Screening to Mouse Model: Identification of New Inhibitor Classes against Prion Disease Chemmedchem. 6: 1928-1937. PMID 21755599 DOI: 10.1002/cmdc.201100119  0.32
2011 Leidel F, Eiden M, Geissen M, Kretzschmar HA, Giese A, Hirschberger T, Tavan P, Schätzl HM, Groschup MH. Diphenylpyrazole-derived compounds increase survival time of mice after prion infection. Antimicrobial Agents and Chemotherapy. 55: 4774-81. PMID 21746938 DOI: 10.1128/AAC.00151-11  0.32
2011 Bader B, Nübling G, Mehle A, Nobile S, Kretzschmar H, Giese A. Single particle analysis of tau oligomer formation induced by metal ions and organic solvents Biochemical and Biophysical Research Communications. 411: 190-196. PMID 21726531 DOI: 10.1016/j.bbrc.2011.06.135  0.32
2011 Lorenz A, Deutschmann M, Ahlfeld J, Prix C, Koch A, Smits R, Fodde R, Kretzschmar HA, Schüller U. Severe alterations of cerebellar cortical development after constitutive activation of Wnt signaling in granule neuron precursors. Molecular and Cellular Biology. 31: 3326-38. PMID 21690300 DOI: 10.1128/MCB.05718-11  0.32
2011 Höglinger GU, Melhem NM, Dickson DW, Sleiman PM, Wang LS, Klei L, Rademakers R, de Silva R, Litvan I, Riley DE, van Swieten JC, Heutink P, Wszolek ZK, Uitti RJ, Vandrovcova J, et al. Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. Nature Genetics. 43: 699-705. PMID 21685912 DOI: 10.1038/ng.859  0.32
2011 Pöschl J, Lorenz A, Hartmann W, von Bueren AO, Kool M, Li S, Peraud A, Tonn JC, Herms J, Xiang M, Rutkowski S, Kretzschmar HA, Schüller U. Expression of BARHL1 in medulloblastoma is associated with prolonged survival in mice and humans. Oncogene. 30: 4721-30. PMID 21602885 DOI: 10.1038/onc.2011.173  0.32
2011 Tranulis MA, Benestad SL, Baron T, Kretzschmar H. Atypical prion diseases in humans and animals Topics in Current Chemistry. 305: 23-50. PMID 21598097 DOI: 10.1007/128_2011_161  0.32
2011 Ottis P, Bader V, Trossbach SV, Kretzschmar H, Michel M, Leliveld SR, Korth C. Convergence of two independent mental disease genes on the protein level: recruitment of dysbindin to cell-invasive disrupted-in-schizophrenia 1 aggresomes. Biological Psychiatry. 70: 604-10. PMID 21531389 DOI: 10.1016/j.biopsych.2011.03.027  0.32
2011 Resenberger UK, Harmeier A, Woerner AC, Goodman JL, Müller V, Krishnan R, Vabulas RM, Kretzschmar HA, Lindquist S, Hartl FU, Multhaup G, Winklhofer KF, Tatzelt J. The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication. The Embo Journal. 30: 2057-70. PMID 21441896 DOI: 10.1038/emboj.2011.86  0.32
2011 Giaccone G, Arzberger T, Alafuzoff I, Al-Sarraj S, Budka H, Duyckaerts C, Falkai P, Ferrer I, Ironside JW, Kovács GG, Meyronet D, Parchi P, Patsouris E, Revesz T, Riederer P, ... ... Kretzschmar H, et al. New lexicon and criteria for the diagnosis of Alzheimer's disease. The Lancet. Neurology. 10: 298-9; author reply . PMID 21435593 DOI: 10.1016/S1474-4422(11)70055-2  0.32
2011 Kreth S, Thon N, Eigenbrod S, Lutz J, Ledderose C, Egensperger R, Tonn JC, Kretzschmar HA, Hinske LC, Kreth FW. O-methylguanine-DNA methyltransferase (MGMT) mRNA expression predicts outcome in malignant glioma independent of MGMT promoter methylation. Plos One. 6: e17156. PMID 21365007 DOI: 10.1371/journal.pone.0017156  0.32
2011 Mollenhauer B, Esselmann H, Trenkwalder C, Schulz-Schaeffer W, Kretzschmar H, Otto M, Wiltfang J, Bibl M. CSF amyloid-β peptides in neuropathologically diagnosed dementia with Lewy bodies and Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 24: 383-91. PMID 21297274 DOI: 10.3233/JAD-2011-101551  0.32
2011 Eigenbrod S, Frick P, Giese A, Schelzke G, Zerr I, Kretzschmar HA. Comprehensive neuropathologic analysis of genetic prion disease associated with the E196K mutation in PRNP reveals phenotypic heterogeneity. Journal of Neuropathology and Experimental Neurology. 70: 192-200. PMID 21293298 DOI: 10.1097/NEN.0b013e31820cd8a4  0.32
2011 Kunz M, Thon N, Eigenbrod S, Hartmann C, Egensperger R, Herms J, Geisler J, la Fougere C, Lutz J, Linn J, Kreth S, von Deimling A, Tonn JC, Kretzschmar HA, Pöpperl G, et al. Hot spots in dynamic (18)FET-PET delineate malignant tumor parts within suspected WHO grade II gliomas. Neuro-Oncology. 13: 307-16. PMID 21292686 DOI: 10.1093/neuonc/noq196  0.32
2011 Schelzke G, Eigenbrod S, Romero C, Varges D, Breithaupt M, Taratuto AL, Kretzschmar HA, Zerr I. Genetic prion disease with codon 196 PRNP mutation: clinical and pathological findings. Neurobiology of Aging. 32: 756.e1-9. PMID 21232818 DOI: 10.1016/j.neurobiolaging.2010.11.023  0.32
2011 Mollenhauer B, Esselmann H, Roeber S, Schulz-Schaeffer WJ, Trenkwalder C, Bibl M, Steinacker P, Kretzschmar HA, Wiltfang J, Otto M. Different CSF β-amyloid processing in Alzheimer's and Creutzfeldt-Jakob disease. Journal of Neural Transmission (Vienna, Austria : 1996). 118: 691-7. PMID 21210287 DOI: 10.1007/s00702-010-0543-z  0.32
2011 Schmitt A, Leonardi-Essmann F, Durrenberger PF, Parlapani E, Schneider-Axmann T, Spanagel R, Arzberger T, Kretzschmar H, Herrera-Marschitz M, Gruber O, Reynolds R, Falkai P, Gebicke-Haerter PJ. Regulation of immune-modulatory genes in left superior temporal cortex of schizophrenia patients: a genome-wide microarray study. The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry. 12: 201-15. PMID 21091092 DOI: 10.3109/15622975.2010.530690  0.32
2011 Mackenzie IR, Munoz DG, Kusaka H, Yokota O, Ishihara K, Roeber S, Kretzschmar HA, Cairns NJ, Neumann M. Distinct pathological subtypes of FTLD-FUS. Acta Neuropathologica. 121: 207-18. PMID 21052700 DOI: 10.1007/s00401-010-0764-0  0.32
2011 Thon N, Eigenbrod S, Grasbon-Frodl EM, Lutz J, Kreth S, Popperl G, Belka C, Kretzschmar HA, Tonn JC, Kreth FW. Predominant influence of MGMT methylation in non-resectable glioblastoma after radiotherapy plus temozolomide. Journal of Neurology, Neurosurgery, and Psychiatry. 82: 441-6. PMID 20861061 DOI: 10.1136/jnnp.2010.214593  0.32
2010 Tang Y, Xiang W, Terry L, Kretzschmar HA, Windl O. Transcriptional analysis implicates endoplasmic reticulum stress in bovine spongiform encephalopathy. Plos One. 5: e14207. PMID 21151970 DOI: 10.1371/journal.pone.0014207  0.32
2010 Steinacker P, Klafki H, Lehnert S, Jesse S, Arnim CA, Tumani H, Pabst A, Kretzschmar HA, Wiltfang J, Otto M. ERK2 is increased in cerebrospinal fluid of Creutzfeldt-Jakob disease patients. Journal of Alzheimer's Disease : Jad. 22: 119-28. PMID 20847405 DOI: 10.3233/JAD-2010-100030  0.32
2010 Schmitt A, Westner IM, Reznicek L, Michels W, Mitteregger G, Kretzschmar HA. Automated decontamination of surface-adherent prions. The Journal of Hospital Infection. 76: 74-9. PMID 20554350 DOI: 10.1016/j.jhin.2010.03.022  0.32
2010 Kreth S, Heyn J, Grau S, Kretzschmar HA, Egensperger R, Kreth FW. Identification of valid endogenous control genes for determining gene expression in human glioma. Neuro-Oncology. 12: 570-9. PMID 20511187 DOI: 10.1093/neuonc/nop072  0.32
2010 Rémi J, Pfefferkorn T, König FB, Lassmann H, Brück W, Holtmannspötter M, Straube A, Kretzschmar HA, Schüller U. A 76-year-old woman with paraplegia. Brain Pathology (Zurich, Switzerland). 20: 507-10. PMID 20438471 DOI: 10.1111/j.1750-3639.2009.00362.x  0.32
2010 Van Deerlin VM, Sleiman PM, Martinez-Lage M, Chen-Plotkin A, Wang LS, Graff-Radford NR, Dickson DW, Rademakers R, Boeve BF, Grossman M, Arnold SE, Mann DM, Pickering-Brown SM, Seelaar H, Heutink P, ... ... Kretzschmar HA, et al. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nature Genetics. 42: 234-9. PMID 20154673 DOI: 10.1038/ng.536  0.32
2010 Steinacker P, Rist W, Swiatek-de-Lange M, Lehnert S, Jesse S, Pabst A, Tumani H, von Arnim CA, Mitrova E, Kretzschmar HA, Lenter M, Wiltfang J, Otto M. Ubiquitin as potential cerebrospinal fluid marker of Creutzfeldt-Jakob disease. Proteomics. 10: 81-9. PMID 19882659 DOI: 10.1002/pmic.200900246  0.32
2009 Thon N, Eigenbrod S, Grasbon-Frodl EM, Ruiter M, Mehrkens JH, Kreth S, Tonn JC, Kretzschmar HA, Kreth FW. Novel molecular stereotactic biopsy procedures reveal intratumoral homogeneity of loss of heterozygosity of 1p/19q and TP53 mutations in World Health Organization grade II gliomas. Journal of Neuropathology and Experimental Neurology. 68: 1219-28. PMID 19816195 DOI: 10.1097/NEN.0b013e3181bee1f1  0.32
2009 Bittner T, Fuhrmann M, Burgold S, Jung CK, Volbracht C, Steiner H, Mitteregger G, Kretzschmar HA, Haass C, Herms J. Gamma-secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 10405-9. PMID 19692615 DOI: 10.1523/JNEUROSCI.2288-09.2009  0.32
2009 Neumann M, Rademakers R, Roeber S, Baker M, Kretzschmar HA, Mackenzie IR. A new subtype of frontotemporal lobar degeneration with FUS pathology. Brain : a Journal of Neurology. 132: 2922-31. PMID 19674978 DOI: 10.1093/brain/awp214  0.32
2009 Neumann M, Roeber S, Kretzschmar HA, Rademakers R, Baker M, Mackenzie IR. Abundant FUS-immunoreactive pathology in neuronal intermediate filament inclusion disease. Acta Neuropathologica. 118: 605-16. PMID 19669651 DOI: 10.1007/s00401-009-0581-5  0.32
2009 Jahn K, Arbusow V, Zingler VC, Strupp M, Kretzschmar HA, Brandt T. Bilateral vestibular failure as an early sign in Creutzfeldt-Jakob disease. Annals of the New York Academy of Sciences. 1164: 390-3. PMID 19645934 DOI: 10.1111/j.1749-6632.2008.03741.x  0.32
2009 Mitteregger G, Korte S, Shakarami M, Herms J, Kretzschmar HA. Role of copper and manganese in prion disease progression. Brain Research. 1292: 155-64. PMID 19635464 DOI: 10.1016/j.brainres.2009.07.051  0.32
2009 Tang Y, Xiang W, Hawkins SA, Kretzschmar HA, Windl O. Transcriptional changes in the brains of cattle orally infected with the bovine spongiform encephalopathy agent precede detection of infectivity. Journal of Virology. 83: 9464-73. PMID 19587050 DOI: 10.1128/JVI.00352-09  0.32
2009 Jesse S, Steinacker P, Cepek L, von Arnim CA, Tumani H, Lehnert S, Kretzschmar HA, Baier M, Otto M. Glial fibrillary acidic protein and protein S-100B: different concentration pattern of glial proteins in cerebrospinal fluid of patients with Alzheimer's disease and Creutzfeldt-Jakob disease. Journal of Alzheimer's Disease : Jad. 17: 541-51. PMID 19433893 DOI: 10.3233/JAD-2009-1075  0.32
2009 Wolschner C, Giese A, Kretzschmar HA, Huber R, Moroder L, Budisa N. Design of anti- and pro-aggregation variants to assess the effects of methionine oxidation in human prion protein. Proceedings of the National Academy of Sciences of the United States of America. 106: 7756-61. PMID 19416900 DOI: 10.1073/pnas.0902688106  0.32
2009 Schnell O, Krebs B, Carlsen J, Miederer I, Goetz C, Goldbrunner RH, Wester HJ, Haubner R, Pöpperl G, Holtmannspötter M, Kretzschmar HA, Kessler H, Tonn JC, Schwaiger M, Beer AJ. Imaging of integrin alpha(v)beta(3) expression in patients with malignant glioma by [18F] Galacto-RGD positron emission tomography. Neuro-Oncology. 11: 861-70. PMID 19401596 DOI: 10.1215/15228517-2009-024  0.32
2009 Pflanz H, Vana K, Mitteregger G, Renner-Müller I, Pace C, Küchenhoff H, Kretzschmar HA, Wolf E, Weiss S. Scrapie-infected transgenic mice expressing a laminin receptor decoy mutant reveal a prolonged incubation time associated with low levels of PrPres. Journal of Molecular Biology. 388: 721-9. PMID 19324055 DOI: 10.1016/j.jmb.2009.03.045  0.32
2009 Meissner B, Kallenberg K, Sanchez-Juan P, Ramljak S, Krasnianski A, Heinemann U, Eigenbrod S, Gelpi E, Barsic B, Kretzschmar HA, Schulz-Schaeffer WJ, Knauth M, Zerr I. MRI and clinical syndrome in dura mater-related Creutzfeldt-Jakob disease. Journal of Neurology. 256: 355-63. PMID 19159063 DOI: 10.1007/s00415-009-0026-z  0.32
2009 Neumann M, Kwong LK, Lee EB, Kremmer E, Flatley A, Xu Y, Forman MS, Troost D, Kretzschmar HA, Trojanowski JQ, Lee VM. Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies. Acta Neuropathologica. 117: 137-49. PMID 19125255 DOI: 10.1007/s00401-008-0477-9  0.32
2009 Pflanz H, Vana K, Mitteregger G, Pace C, Messow D, Sedlaczek C, Nikles D, Kretzschmar HA, Weiss SF. Microinjection of lentiviral vectors expressing small interfering RNAs directed against laminin receptor precursor mRNA prolongs the pre-clinical phase in scrapie-infected mice. The Journal of General Virology. 90: 269-74. PMID 19088298 DOI: 10.1099/vir.0.004168-0  0.32
2009 Parchi P, Notari S, Weber P, Schimmel H, Budka H, Ferrer I, Haik S, Hauw JJ, Head MW, Ironside JW, Limido L, Rodriguez A, Ströbel T, Tagliavini F, Kretzschmar HA. Inter-laboratory assessment of PrPSc typing in creutzfeldt-jakob disease: a Western blot study within the NeuroPrion Consortium. Brain Pathology (Zurich, Switzerland). 19: 384-91. PMID 18624793 DOI: 10.1111/j.1750-3639.2008.00187.x  0.32
2009 Gmitterová K, Heinemann U, Bodemer M, Krasnianski A, Meissner B, Kretzschmar HA, Zerr I. 14-3-3 CSF levels in sporadic Creutzfeldt-Jakob disease differ across molecular subtypes. Neurobiology of Aging. 30: 1842-50. PMID 18328602 DOI: 10.1016/j.neurobiolaging.2008.01.007  0.32
2009 Priller C, Mitteregger G, Paluch S, Vassallo N, Staufenbiel M, Kretzschmar HA, Jucker M, Herms J. Excitatory synaptic transmission is depressed in cultured hippocampal neurons of APP/PS1 mice. Neurobiology of Aging. 30: 1227-37. PMID 18077058 DOI: 10.1016/j.neurobiolaging.2007.10.016  0.32
2009 Krasnianski A, von Ahsen N, Heinemann U, Meissner B, Schulz-Schaeffer WJ, Kretzschmar HA, Armstrong VW, Zerr I. Increased frequency of positive family history of dementia in sporadic CJD. Neurobiology of Aging. 30: 615-21. PMID 17822808 DOI: 10.1016/j.neurobiolaging.2007.07.014  0.32
2008 Steinacker P, Hendrich C, Sperfeld AD, Jesse S, von Arnim CA, Lehnert S, Pabst A, Uttner I, Tumani H, Lee VM, Trojanowski JQ, Kretzschmar HA, Ludolph A, Neumann M, Otto M. TDP-43 in cerebrospinal fluid of patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Archives of Neurology. 65: 1481-7. PMID 19001167 DOI: 10.1001/archneur.65.11.1481  0.32
2008 Heinemann U, Krasnianski A, Meissner B, Kallenberg K, Kretzschmar HA, Schulz-Schaeffer W, Zerr I. Brain biopsy in patients with suspected Creutzfeldt-Jakob disease. Journal of Neurosurgery. 109: 735-41. PMID 18826363 DOI: 10.3171/JNS/2008/109/10/0735  0.32
2008 Brechlin P, Jahn O, Steinacker P, Cepek L, Kratzin H, Lehnert S, Jesse S, Mollenhauer B, Kretzschmar HA, Wiltfang J, Otto M. Cerebrospinal fluid-optimized two-dimensional difference gel electrophoresis (2-D DIGE) facilitates the differential diagnosis of Creutzfeldt-Jakob disease. Proteomics. 8: 4357-66. PMID 18814332 DOI: 10.1002/pmic.200800375  0.32
2008 Kühnlein P, Sperfeld AD, Vanmassenhove B, Van Deerlin V, Lee VM, Trojanowski JQ, Kretzschmar HA, Ludolph AC, Neumann M. Two German kindreds with familial amyotrophic lateral sclerosis due to TARDBP mutations. Archives of Neurology. 65: 1185-9. PMID 18779421 DOI: 10.1001/archneur.65.9.1185  0.32
2008 Neumann M, Kretzschmar HA. [Molecular neuropathology of Non-Alzheimer dementia]. Der Pathologe. 29: 434-41. PMID 18773209 DOI: 10.1007/s00292-008-1063-6  0.32
2008 Notari S, Strammiello R, Capellari S, Giese A, Cescatti M, Grassi J, Ghetti B, Langeveld JP, Zou WQ, Gambetti P, Kretzschmar HA, Parchi P. Characterization of truncated forms of abnormal prion protein in Creutzfeldt-Jakob disease. The Journal of Biological Chemistry. 283: 30557-65. PMID 18753138 DOI: 10.1074/jbc.M801877200  0.32
2008 Krasnianski A, Kallenberg K, Collie DA, Meissner B, Schulz-Schaeffer WJ, Heinemann U, Varges D, Summers DM, Kretzschmar HA, Talbot T, Will RG, Zerr I. MRI in the classical MM1 and the atypical MV2 subtypes of sporadic CJD: an inter-observer agreement study. European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies. 15: 762-71. PMID 18684308 DOI: 10.1111/j.1468-1331.2008.02209.x  0.32
2008 Zuber C, Mitteregger G, Schuhmann N, Rey C, Knackmuss S, Rupprecht W, Reusch U, Pace C, Little M, Kretzschmar HA, Hallek M, Büning H, Weiss S. Delivery of single-chain antibodies (scFvs) directed against the 37/67 kDa laminin receptor into mice via recombinant adeno-associated viral vectors for prion disease gene therapy. The Journal of General Virology. 89: 2055-61. PMID 18632978 DOI: 10.1099/vir.0.83670-0  0.32
2008 Mollenhauer B, Cullen V, Kahn I, Krastins B, Outeiro TF, Pepivani I, Ng J, Schulz-Schaeffer W, Kretzschmar HA, McLean PJ, Trenkwalder C, Sarracino DA, Vonsattel JP, Locascio JJ, El-Agnaf OM, et al. Direct quantification of CSF alpha-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration. Experimental Neurology. 213: 315-25. PMID 18625222 DOI: 10.1016/j.expneurol.2008.06.004  0.32
2008 Mittelbronn M, Capper D, Bader B, Schittenhelm J, Haybaeck J, Weber P, Meyermann R, Kretzschmar HA, Wietholter H. Severe hypoxia and multiple infarctions resembling Creutzfeldt-Jakob disease. Folia Neuropathologica / Association of Polish Neuropathologists and Medical Research Centre, Polish Academy of Sciences. 46: 149-53. PMID 18587709  0.32
2008 Crecelius AC, Helmstetter D, Strangmann J, Mitteregger G, Fröhlich T, Arnold GJ, Kretzschmar HA. The brain proteome profile is highly conserved between Prnp-/- and Prnp+/+ mice. Neuroreport. 19: 1027-31. PMID 18580573 DOI: 10.1097/WNR.0b013e3283046157  0.32
2008 Roeber S, Mackenzie IR, Kretzschmar HA, Neumann M. TDP-43-negative FTLD-U is a significant new clinico-pathological subtype of FTLD. Acta Neuropathologica. 116: 147-57. PMID 18536926 DOI: 10.1007/s00401-008-0395-x  0.32
2008 Uryu K, Nakashima-Yasuda H, Forman MS, Kwong LK, Clark CM, Grossman M, Miller BL, Kretzschmar HA, Lee VM, Trojanowski JQ, Neumann M. Concomitant TAR-DNA-binding protein 43 pathology is present in Alzheimer disease and corticobasal degeneration but not in other tauopathies. Journal of Neuropathology and Experimental Neurology. 67: 555-64. PMID 18520774 DOI: 10.1097/NEN.0b013e31817713b5  0.32
2008 Schmalzbauer R, Eigenbrod S, Winoto-Morbach S, Xiang W, Schütze S, Bertsch U, Kretzschmar HA. Evidence for an association of prion protein and sphingolipid-mediated signaling. Journal of Neurochemistry. 106: 1459-70. PMID 18498440 DOI: 10.1111/j.1471-4159.2008.05498.x  0.32
2008 Roeber S, Grasbon-Frodl EM, Windl O, Krebs B, Xiang W, Vollmert C, Illig T, Schröter A, Arzberger T, Weber P, Zerr I, Kretzschmar HA. Evidence for a pathogenic role of different mutations at codon 188 of PRNP. Plos One. 3: e2147. PMID 18478114 DOI: 10.1371/journal.pone.0002147  0.32
2008 Heinemann U, Krasnianski A, Meissner B, Grasbon-Frodl EM, Kretzschmar HA, Zerr I. Novel PRNP mutation in a patient with a slow progressive dementia syndrome. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research. 14: CS41-43. PMID 18443555  0.32
2008 Schnell O, Krebs B, Wagner E, Romagna A, Beer AJ, Grau SJ, Thon N, Goetz C, Kretzschmar HA, Tonn JC, Goldbrunner RH. Expression of integrin alphavbeta3 in gliomas correlates with tumor grade and is not restricted to tumor vasculature. Brain Pathology (Zurich, Switzerland). 18: 378-86. PMID 18394009 DOI: 10.1111/j.1750-3639.2008.00137.x  0.32
2008 Krasnianski A, Bartl M, Sanchez Juan PJ, Heinemann U, Meissner B, Varges D, Schulze-Sturm U, Kretzschmar HA, Schulz-Schaeffer WJ, Zerr I. Fatal familial insomnia: Clinical features and early identification. Annals of Neurology. 63: 658-61. PMID 18360821 DOI: 10.1002/ana.21358  0.32
2008 Crecelius A, Götz A, Arzberger T, Fröhlich T, Arnold GJ, Ferrer I, Kretzschmar HA. Assessing quantitative post-mortem changes in the gray matter of the human frontal cortex proteome by 2-D DIGE. Proteomics. 8: 1276-91. PMID 18283663 DOI: 10.1002/pmic.200700728  0.32
2008 Friedrich M, Körte R, Portero C, Arzberger T, Kretzschmar HA, Zerr I, Nacimiento W. [Fatal familial insomnia--a rare differential diagnosis in dementia]. Fortschritte Der Neurologie-Psychiatrie. 76: 36-40. PMID 18189221 DOI: 10.1055/s-2007-996169  0.32
2008 Schüller U, Ruiter M, Herms J, Kretzschmar HA, Grasbon-Frodl E. Absence of mutations in the AKT1 oncogene in glioblastomas and medulloblastomas. Acta Neuropathologica. 115: 367-8. PMID 18172656 DOI: 10.1007/s00401-007-0334-2  0.32
2008 Krasnianski A, von Ahsen N, Heinemann U, Meissner B, Kretzschmar HA, Armstrong VW, Zerr I. ApoE distribution and family history in genetic prion diseases in Germany. Journal of Molecular Neuroscience : Mn. 34: 45-50. PMID 18157657 DOI: 10.1007/s12031-007-9001-2  0.32
2008 Zuber C, Knackmuss S, Rey C, Reusch U, Röttgen P, Fröhlich T, Arnold GJ, Pace C, Mitteregger G, Kretzschmar HA, Little M, Weiss S. Single chain Fv antibodies directed against the 37 kDa/67 kDa laminin receptor as therapeutic tools in prion diseases. Molecular Immunology. 45: 144-51. PMID 17576014 DOI: 10.1016/j.molimm.2007.04.030  0.32
2008 Bader B, Arzberger T, Heinsen H, Dobson-Stone C, Kretzschmar HA, Danek A. Neuropathology of chorea-acanthocytosis Neuroacanthocytosis Syndromes Ii. 187-195. DOI: 10.1007/978-3-540-71693-8_15  0.32
2007 Zuber C, Mitteregger G, Pace C, Zerr I, Kretzschmar HA, Weiss S. Anti-LRP/LR antibody W3 hampers peripheral PrPSc propagation in scrapie infected mice. Prion. 1: 207-12. PMID 19164931  0.32
2007 Paludi D, Thellung S, Chiovitti K, Corsaro A, Villa V, Russo C, Ianieri A, Bertsch U, Kretzschmar HA, Aceto A, Florio T. Different structural stability and toxicity of PrP(ARR) and PrP(ARQ) sheep prion protein variants. Journal of Neurochemistry. 103: 2291-300. PMID 17919292 DOI: 10.1111/j.1471-4159.2007.04934.x  0.32
2007 Notari S, Capellari S, Langeveld J, Giese A, Strammiello R, Gambetti P, Kretzschmar HA, Parchi P. A refined method for molecular typing reveals that co-occurrence of PrP(Sc) types in Creutzfeldt-Jakob disease is not the rule. Laboratory Investigation; a Journal of Technical Methods and Pathology. 87: 1103-12. PMID 17893675 DOI: 10.1038/labinvest.3700676  0.32
2007 Pöpperl G, Kreth FW, Mehrkens JH, Herms J, Seelos K, Koch W, Gildehaus FJ, Kretzschmar HA, Tonn JC, Tatsch K. FET PET for the evaluation of untreated gliomas: correlation of FET uptake and uptake kinetics with tumour grading. European Journal of Nuclear Medicine and Molecular Imaging. 34: 1933-42. PMID 17763848 DOI: 10.1007/s00259-007-0534-y  0.32
2007 Hamid R, Kilger E, Willem M, Vassallo N, Kostka M, Bornhövd C, Reichert AS, Kretzschmar HA, Haass C, Herms J. Amyloid precursor protein intracellular domain modulates cellular calcium homeostasis and ATP content. Journal of Neurochemistry. 102: 1264-75. PMID 17763532 DOI: 10.1111/j.1471-4159.2007.04627.x  0.32
2007 Grasbon-Frodl EM, Kreth FW, Ruiter M, Schnell O, Bise K, Felsberg J, Reifenberger G, Tonn JC, Kretzschmar HA. Intratumoral homogeneity of MGMT promoter hypermethylation as demonstrated in serial stereotactic specimens from anaplastic astrocytomas and glioblastomas. International Journal of Cancer. Journal International Du Cancer. 121: 2458-64. PMID 17691113 DOI: 10.1002/ijc.23020  0.32
2007 Mollenhauer B, Steinacker P, Bahn E, Bibl M, Brechlin P, Schlossmacher MG, Locascio JJ, Wiltfang J, Kretzschmar HA, Poser S, Trenkwalder C, Otto M. Serum heart-type fatty acid-binding protein and cerebrospinal fluid tau: marker candidates for dementia with Lewy bodies. Neuro-Degenerative Diseases. 4: 366-75. PMID 17622779 DOI: 10.1159/000105157  0.32
2007 Cairns NJ, Neumann M, Bigio EH, Holm IE, Troost D, Hatanpaa KJ, Foong C, White CL, Schneider JA, Kretzschmar HA, Carter D, Taylor-Reinwald L, Paulsmeyer K, Strider J, Gitcho M, et al. TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions. The American Journal of Pathology. 171: 227-40. PMID 17591968 DOI: 10.2353/ajpath.2007.070182  0.32
2007 Krebs B, Bader B, Klehmet J, Grasbon-Frodl E, Oertel WH, Zerr I, Stricker S, Zschenderlein R, Kretzschmar HA. A novel subtype of Creutzfeldt-Jakob disease characterized by a small 6 kDa PrP fragment. Acta Neuropathologica. 114: 195-9. PMID 17576581 DOI: 10.1007/s00401-007-0242-5  0.32
2007 Tschampa HJ, Kallenberg K, Kretzschmar HA, Meissner B, Knauth M, Urbach H, Zerr I. Pattern of cortical changes in sporadic Creutzfeldt-Jakob disease. Ajnr. American Journal of Neuroradiology. 28: 1114-8. PMID 17569970 DOI: 10.3174/ajnr.A0496  0.32
2007 Heinemann U, Krasnianski A, Meissner B, Gloeckner SF, Kretzschmar HA, Zerr I. Molecular subtype-specific clinical diagnosis of prion diseases. Veterinary Microbiology. 123: 328-35. PMID 17513070 DOI: 10.1016/j.vetmic.2007.04.002  0.32
2007 Weber P, Giese A, Piening N, Mitteregger G, Thomzig A, Beekes M, Kretzschmar HA. Generation of genuine prion infectivity by serial PMCA. Veterinary Microbiology. 123: 346-57. PMID 17493773 DOI: 10.1016/j.vetmic.2007.04.004  0.32
2007 Weiss A, Del Pino P, Bertsch U, Renner C, Mentler M, Grantner K, Moroder L, Kretzschmar HA, Parak FG. The configuration of the Cu(2+) binding region in full-length human prion protein compared with the isolated octapeptide. Veterinary Microbiology. 123: 358-66. PMID 17482774 DOI: 10.1016/j.vetmic.2007.04.008  0.32
2007 Heinemann U, Krasnianski A, Meissner B, Varges D, Kallenberg K, Schulz-Schaeffer WJ, Steinhoff BJ, Grasbon-Frodl EM, Kretzschmar HA, Zerr I. Creutzfeldt-Jakob disease in Germany: a prospective 12-year surveillance. Brain : a Journal of Neurology. 130: 1350-9. PMID 17472986 DOI: 10.1093/brain/awm063  0.32
2007 Mackenzie IR, Bigio EH, Ince PG, Geser F, Neumann M, Cairns NJ, Kwong LK, Forman MS, Ravits J, Stewart H, Eisen A, McClusky L, Kretzschmar HA, Monoranu CM, Highley JR, et al. Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations. Annals of Neurology. 61: 427-34. PMID 17469116 DOI: 10.1002/ana.21147  0.32
2007 Xiang W, Hummel M, Mitteregger G, Pace C, Windl O, Mansmann U, Kretzschmar HA. Transcriptome analysis reveals altered cholesterol metabolism during the neurodegeneration in mouse scrapie model. Journal of Neurochemistry. 102: 834-47. PMID 17437544 DOI: 10.1111/j.1471-4159.2007.04566.x  0.32
2007 Neumann M, Igaz LM, Kwong LK, Nakashima-Yasuda H, Kolb SJ, Dreyfuss G, Kretzschmar HA, Trojanowski JQ, Lee VM. Absence of heterogeneous nuclear ribonucleoproteins and survival motor neuron protein in TDP-43 positive inclusions in frontotemporal lobar degeneration. Acta Neuropathologica. 113: 543-8. PMID 17415574 DOI: 10.1007/s00401-007-0221-x  0.32
2007 Mitteregger G, Vosko M, Krebs B, Xiang W, Kohlmannsperger V, Nölting S, Hamann GF, Kretzschmar HA. The role of the octarepeat region in neuroprotective function of the cellular prion protein. Brain Pathology (Zurich, Switzerland). 17: 174-83. PMID 17388948 DOI: 10.1111/j.1750-3639.2007.00061.x  0.32
2007 Neumann M, Kwong LK, Truax AC, Vanmassenhove B, Kretzschmar HA, Van Deerlin VM, Clark CM, Grossman M, Miller BL, Trojanowski JQ, Lee VM. TDP-43-positive white matter pathology in frontotemporal lobar degeneration with ubiquitin-positive inclusions. Journal of Neuropathology and Experimental Neurology. 66: 177-83. PMID 17356379 DOI: 10.1097/01.jnen.0000248554.45456.58  0.32
2007 Neumann M, Mackenzie IR, Cairns NJ, Boyer PJ, Markesbery WR, Smith CD, Taylor JP, Kretzschmar HA, Kimonis VE, Forman MS. TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations. Journal of Neuropathology and Experimental Neurology. 66: 152-7. PMID 17279000 DOI: 10.1097/nen.0b013e31803020b9  0.32
2007 Sostak P, Theil D, Stepp H, Roeber S, Kretzschmar HA, Straube A. Detection of bone marrow-derived cells expressing a neural phenotype in the human brain. Journal of Neuropathology and Experimental Neurology. 66: 110-6. PMID 17278995 DOI: 10.1097/nen.0b013e3180301be8  0.32
2007 Krebs B, Wiebelitz A, Balitzki-Korte B, Vassallo N, Paluch S, Mitteregger G, Onodera T, Kretzschmar HA, Herms J. Cellular prion protein modulates the intracellular calcium response to hydrogen peroxide. Journal of Neurochemistry. 100: 358-67. PMID 17241158 DOI: 10.1111/j.1471-4159.2006.04256.x  0.32
2007 del Pino P, Weiss A, Bertsch U, Renner C, Mentler M, Grantner K, Fiorino F, Meyer-Klaucke W, Moroder L, Kretzschmar HA, Parak FG. The configuration of the Cu2+ binding region in full-length human prion protein. European Biophysics Journal : Ebj. 36: 239-52. PMID 17225136 DOI: 10.1007/s00249-006-0124-0  0.32
2007 Schiffer NW, Broadley SA, Hirschberger T, Tavan P, Kretzschmar HA, Giese A, Haass C, Hartl FU, Schmid B. Identification of anti-prion compounds as efficient inhibitors of polyglutamine protein aggregation in a zebrafish model. The Journal of Biological Chemistry. 282: 9195-203. PMID 17170113 DOI: 10.1074/jbc.M607865200  0.32
2007 Priller C, Dewachter I, Vassallo N, Paluch S, Pace C, Kretzschmar HA, Van Leuven F, Herms J. Mutant presenilin 1 alters synaptic transmission in cultured hippocampal neurons. The Journal of Biological Chemistry. 282: 1119-27. PMID 17088253 DOI: 10.1074/jbc.M605066200  0.32
2007 Cepek L, Brechlin P, Steinacker P, Mollenhauer B, Klingebiel E, Bibl M, Kretzschmar HA, Wiltfang J, Otto M. Proteomic analysis of the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease. Dementia and Geriatric Cognitive Disorders. 23: 22-8. PMID 17068393 DOI: 10.1159/000096589  0.32
2007 Freichel C, Neumann M, Ballard T, Müller V, Woolley M, Ozmen L, Borroni E, Kretzschmar HA, Haass C, Spooren W, Kahle PJ. Age-dependent cognitive decline and amygdala pathology in alpha-synuclein transgenic mice. Neurobiology of Aging. 28: 1421-35. PMID 16872721 DOI: 10.1016/j.neurobiolaging.2006.06.013  0.32
2006 Vollmert C, Windl O, Xiang W, Rosenberger A, Zerr I, Wichmann HE, Bickeböller H, Illig T, Kretzschmar HA. Significant association of a M129V independent polymorphism in the 5' UTR of the PRNP gene with sporadic Creutzfeldt-Jakob disease in a large German case-control study. Journal of Medical Genetics. 43: e53. PMID 17047093 DOI: 10.1136/jmg.2006.040931  0.32
2006 Weber P, Giese A, Piening N, Mitteregger G, Thomzig A, Beekes M, Kretzschmar HA. Cell-free formation of misfolded prion protein with authentic prion infectivity. Proceedings of the National Academy of Sciences of the United States of America. 103: 15818-23. PMID 17030802 DOI: 10.1073/pnas.0605608103  0.32
2006 Neumann M, Sampathu DM, Kwong LK, Truax AC, Micsenyi MC, Chou TT, Bruce J, Schuck T, Grossman M, Clark CM, McCluskey LF, Miller BL, Masliah E, Mackenzie IR, Feldman H, ... ... Kretzschmar HA, et al. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science (New York, N.Y.). 314: 130-3. PMID 17023659 DOI: 10.1126/science.1134108  0.32
2006 Boesenberg-Grosse C, Schulz-Schaeffer WJ, Bodemer M, Ciesielczyk B, Meissner B, Krasnianski A, Bartl M, Heinemann U, Varges D, Eigenbrod S, Kretzschmar HA, Green A, Zerr I. Brain-derived proteins in the CSF: do they correlate with brain pathology in CJD? Bmc Neurology. 6: 35. PMID 16989662 DOI: 10.1186/1471-2377-6-35  0.32
2006 Fröhlich T, Helmstetter D, Zobawa M, Crecelius AC, Arzberger T, Kretzschmar HA, Arnold GJ. Analysis of the HUPO Brain Proteome reference samples using 2-D DIGE and 2-D LC-MS/MS. Proteomics. 6: 4950-66. PMID 16927427 DOI: 10.1002/pmic.200600079  0.32
2006 Roeber S, Bäzner H, Hennerici M, Porstmann R, Kretzschmar HA. Neurodegeneration with features of NIFID and ALS--extended clinical and neuropathological spectrum. Brain Pathology (Zurich, Switzerland). 16: 228-34. PMID 16911480 DOI: 10.1111/j.1750-3639.2006.00013.x  0.32
2006 Priller C, Bauer T, Mitteregger G, Krebs B, Kretzschmar HA, Herms J. Synapse formation and function is modulated by the amyloid precursor protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 7212-21. PMID 16822978 DOI: 10.1523/JNEUROSCI.1450-06.2006  0.32
2006 Krasnianski A, Meissner B, Schulz-Schaeffer W, Kallenberg K, Bartl M, Heinemann U, Varges D, Kretzschmar HA, Zerr I. Clinical features and diagnosis of the MM2 cortical subtype of sporadic Creutzfeldt-Jakob disease. Archives of Neurology. 63: 876-80. PMID 16769870 DOI: 10.1001/archneur.63.6.876  0.32
2006 Krasnianski A, Schulz-Schaeffer WJ, Kallenberg K, Meissner B, Collie DA, Roeber S, Bartl M, Heinemann U, Varges D, Kretzschmar HA, Zerr I. Clinical findings and diagnostic tests in the MV2 subtype of sporadic CJD. Brain : a Journal of Neurology. 129: 2288-96. PMID 16720682 DOI: 10.1093/brain/awl123  0.32
2006 Barnewitz K, Maringer M, Mitteregger G, Giese A, Bertsch U, Kretzschmar HA. Unaltered prion protein cleavage in plasminogen-deficient mice. Neuroreport. 17: 527-30. PMID 16543819 DOI: 10.1097/01.wnr.0000209003.55728.ac  0.32
2006 Pöpperl G, Kreth FW, Herms J, Koch W, Mehrkens JH, Gildehaus FJ, Kretzschmar HA, Tonn JC, Tatsch K. Analysis of 18F-FET PET for grading of recurrent gliomas: is evaluation of uptake kinetics superior to standard methods? Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 47: 393-403. PMID 16513607  0.32
2006 Piening N, Nonno R, Di Bari M, Walter S, Windl O, Agrimi U, Kretzschmar HA, Bertsch U. Conversion efficiency of bank vole prion protein in vitro is determined by residues 155 and 170, but does not correlate with the high susceptibility of bank voles to sheep scrapie in vivo. The Journal of Biological Chemistry. 281: 9373-84. PMID 16455657 DOI: 10.1074/jbc.M512239200  0.32
2006 Krebs B, Kohlmannsperger V, Nölting S, Schmalzbauer R, Kretzschmar HA. A method to perform Western blots of microscopic areas of histological sections. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 54: 559-65. PMID 16399998 DOI: 10.1369/jhc.5A6818.2006  0.32
2006 Krebs B, Dorner-Ciossek C, Schmalzbauer R, Vassallo N, Herms J, Kretzschmar HA. Prion protein induced signaling cascades in monocytes. Biochemical and Biophysical Research Communications. 340: 13-22. PMID 16343423 DOI: 10.1016/j.bbrc.2005.11.158  0.32
2005 Windl O, Buchholz M, Neubauer A, Schulz-Schaeffer W, Groschup M, Walter S, Arendt S, Neumann M, Voss AK, Kretzschmar HA. Breaking an absolute species barrier: transgenic mice expressing the mink PrP gene are susceptible to transmissible mink encephalopathy. Journal of Virology. 79: 14971-5. PMID 16282497 DOI: 10.1128/JVI.79.23.14971-14975.2005  0.32
2005 Giese A, Buchholz M, Herms J, Kretzschmar HA. Mouse brain synaptosomes accumulate copper-67 efficiently by two distinct processes independent of cellular prion protein. Journal of Molecular Neuroscience : Mn. 27: 347-54. PMID 16280605 DOI: 10.1385/JMN:27:3:347  0.32
2005 Meissner B, Westner IM, Kallenberg K, Krasnianski A, Bartl M, Varges D, Bösenberg C, Kretzschmar HA, Knauth M, Schulz-Schaeffer WJ, Zerr I. Sporadic Creutzfeldt-Jakob disease: clinical and diagnostic characteristics of the rare VV1 type. Neurology. 65: 1544-50. PMID 16221949 DOI: 10.1212/01.wnl.0000184674.32924.c9  0.32
2005 Kovács GG, Puopolo M, Ladogana A, Pocchiari M, Budka H, van Duijn C, Collins SJ, Boyd A, Giulivi A, Coulthart M, Delasnerie-Laupretre N, Brandel JP, Zerr I, Kretzschmar HA, de Pedro-Cuesta J, et al. Genetic prion disease: the EUROCJD experience. Human Genetics. 118: 166-74. PMID 16187142 DOI: 10.1007/s00439-005-0020-1  0.32
2005 Ludlam CA, Mannucci PM, Powderly WG, Roca CA, Astermark J, Auerswald G, Garcia Barrios M, Chistolini A, Dolan G, Gringeri A, Hermans C, Laurian Y, Lopez RP, Peerlinck K, Pollmann H, ... ... Kretzschmar HA, et al. Addressing current challenges in haemophilia care: Consensus recommendations of a European Interdisciplinary Working Group Haemophilia. 11: 433-437. PMID 16128884 DOI: 10.1111/j.1365-2516.2005.01130.x  0.32
2005 Xiang W, Windl O, Westner IM, Neumann M, Zerr I, Lederer RM, Kretzschmar HA. Cerebral gene expression profiles in sporadic Creutzfeldt-Jakob disease. Annals of Neurology. 58: 242-57. PMID 16049922 DOI: 10.1002/ana.20551  0.32
2005 Boesenberg C, Schulz-Schaeffer WJ, Meissner B, Kallenberg K, Bartl M, Heinemann U, Krasnianski A, Stoeck K, Varges D, Windl O, Kretzschmar HA, Zerr I. Clinical course in young patients with sporadic Creutzfeldt-Jakob disease. Annals of Neurology. 58: 533-43. PMID 16037975 DOI: 10.1002/ana.20568  0.32
2005 Neumann M, Mittelbronn M, Simon P, Vanmassenhove B, de Silva R, Lees A, Klapp J, Meyermann R, Kretzschmar HA. A new family with frontotemporal dementia with intronic 10+3 splice site mutation in the tau gene: neuropathology and molecular effects. Neuropathology and Applied Neurobiology. 31: 362-73. PMID 16008820 DOI: 10.1111/j.1365-2990.2005.00629.x  0.32
2005 Sarafoff NI, Bieschke J, Giese A, Weber P, Bertsch U, Kretzschmar HA. Automated PrPres amplification using indirect sonication. Journal of Biochemical and Biophysical Methods. 63: 213-21. PMID 15967508 DOI: 10.1016/j.jbbm.2005.05.004  0.32
2005 Tschampa HJ, Kallenberg K, Urbach H, Meissner B, Nicolay C, Kretzschmar HA, Knauth M, Zerr I. MRI in the diagnosis of sporadic Creutzfeldt-Jakob disease: a study on inter-observer agreement. Brain : a Journal of Neurology. 128: 2026-33. PMID 15958503 DOI: 10.1093/brain/awh575  0.32
2005 Mollenhauer B, Bibl M, Trenkwalder C, Stiens G, Cepek L, Steinacker P, Ciesielczyk B, Neubert K, Wiltfang J, Kretzschmar HA, Poser S, Otto M. Follow-up investigations in cerebrospinal fluid of patients with dementia with Lewy bodies and Alzheimer's disease. Journal of Neural Transmission (Vienna, Austria : 1996). 112: 933-48. PMID 15937638 DOI: 10.1007/s00702-004-0235-7  0.32
2005 Bertsch U, Winklhofer KF, Hirschberger T, Bieschke J, Weber P, Hartl FU, Tavan P, Tatzelt J, Kretzschmar HA, Giese A. Systematic identification of antiprion drugs by high-throughput screening based on scanning for intensely fluorescent targets. Journal of Virology. 79: 7785-91. PMID 15919931 DOI: 10.1128/JVI.79.12.7785-7791.2005  0.32
2005 Vassallo N, Herms J, Behrens C, Krebs B, Saeki K, Onodera T, Windl O, Kretzschmar HA. Activation of phosphatidylinositol 3-kinase by cellular prion protein and its role in cell survival. Biochemical and Biophysical Research Communications. 332: 75-82. PMID 15896301 DOI: 10.1016/j.bbrc.2005.04.099  0.32
2005 Cepek L, Steinacker P, Mollenhauer B, Wiese B, Ciesielczyk B, Bibl M, Wiltfang J, Zerr I, Schulz-Schaeffer W, Kretzschmar HA, Poser S, Otto M. Follow-up investigations of tau protein and S-100B levels in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease. Dementia and Geriatric Cognitive Disorders. 19: 376-82. PMID 15802913 DOI: 10.1159/000084708  0.32
2005 Zingler VC, Strupp M, Jahn K, Glaser M, Herberger S, Kretzschmar HA, Brandt T. Upbeat nystagmus as the initial clinical sign of Creutzfeldt-Jakob disease. Annals of Neurology. 57: 607-8. PMID 15786473 DOI: 10.1002/ana.20435  0.32
2005 Krebs B, Lederer RM, Windl O, Grasbon-Frodl EM, Zerr I, Kretzschmar HA. Creutzfeldt-Jakob disease associated with an R148H mutation of the prion protein gene. Neurogenetics. 6: 97-100. PMID 15776279 DOI: 10.1007/s10048-004-0208-x  0.32
2005 Neumann M, Diekmann S, Bertsch U, Vanmassenhove B, Bogerts B, Kretzschmar HA. Novel G335V mutation in the tau gene associated with early onset familial frontotemporal dementia. Neurogenetics. 6: 91-5. PMID 15765246 DOI: 10.1007/s10048-005-0210-y  0.32
2005 Roeber S, Krebs B, Neumann M, Windl O, Zerr I, Grasbon-Frodl EM, Kretzschmar HA. Creutzfeldt-Jakob disease in a patient with an R208H mutation of the prion protein gene (PRNP) and a 17-kDa prion protein fragment. Acta Neuropathologica. 109: 443-8. PMID 15739100 DOI: 10.1007/s00401-004-0978-0  0.32
2005 Bleich S, Otto M, Zerr I, Kropp S, Kretzschmar HA, Wiltfang J. Creutzfeldt-Jakob disease and homocysteine levels in plasma and cerebrospinal fluid. Gerontology. 51: 142-4. PMID 15711082 DOI: 10.1159/000082200  0.32
2005 Jacobi C, Arlt S, Reiber H, Westner I, Kretzschmar HA, Poser S, Zerr I. Immunoglobulins and virus-specific antibodies in patients with Creutzfeldt-Jakob disease. Acta Neurologica Scandinavica. 111: 185-90. PMID 15691288 DOI: 10.1111/j.1600-0404.2005.00330.x  0.32
2005 Stork M, Giese A, Kretzschmar HA, Tavan P. Molecular dynamics simulations indicate a possible role of parallel beta-helices in seeded aggregation of poly-Gln. Biophysical Journal. 88: 2442-51. PMID 15665127 DOI: 10.1529/biophysj.104.052415  0.32
2005 Schankin CJ, Birnbaum T, Linn J, Brüning R, Kretzschmar HA, Straube A, Krebs B. A fatal encephalitis. Lancet. 365: 358. PMID 15664235 DOI: 10.1016/S0140-6736(05)17794-0  0.32
2005 Mollenhauer B, Cepek L, Bibl M, Wiltfang J, Schulz-Schaeffer WJ, Ciesielczyk B, Neumann M, Steinacker P, Kretzschmar HA, Poser S, Trenkwalder C, Otto M. Tau protein, Abeta42 and S-100B protein in cerebrospinal fluid of patients with dementia with Lewy bodies. Dementia and Geriatric Cognitive Disorders. 19: 164-70. PMID 15637452 DOI: 10.1159/000083178  0.32
2005 Albrecht R, Krebs B, Reusche E, Nagel M, Lencer R, Kretzschmar HA. Signs of rapidly progressive dementia in a case of intravascular lymphomatosis. European Archives of Psychiatry and Clinical Neuroscience. 255: 232-5. PMID 15565300 DOI: 10.1007/s00406-004-0551-9  0.32
2005 Hampel H, Haslinger A, Scheloske M, Padberg F, Fischer P, Unger J, Teipel SJ, Neumann M, Rosenberg C, Oshida R, Hulette C, Pongratz D, Ewers M, Kretzschmar HA, Möller HJ. Pattern of interleukin-6 receptor complex immunoreactivity between cortical regions of rapid autopsy normal and Alzheimer's disease brain. European Archives of Psychiatry and Clinical Neuroscience. 255: 269-78. PMID 15565298 DOI: 10.1007/s00406-004-0558-2  0.32
2005 Mentler M, Weiss A, Grantner K, del Pino P, Deluca D, Fiori S, Renner C, Klaucke WM, Moroder L, Bertsch U, Kretzschmar HA, Tavan P, Parak FG. A new method to determine the structure of the metal environment in metalloproteins: investigation of the prion protein octapeptide repeat Cu(2+) complex. European Biophysics Journal : Ebj. 34: 97-112. PMID 15452673 DOI: 10.1007/s00249-004-0434-z  0.32
2004 Neumann M, Müller V, Kretzschmar HA, Haass C, Kahle PJ. Regional distribution of proteinase K-resistant alpha-synuclein correlates with Lewy body disease stage. Journal of Neuropathology and Experimental Neurology. 63: 1225-35. PMID 15624759  0.32
2004 Klünemann HH, Rogaeva E, Neumann M, Kretzschmar HA, Kandel M, Toulina A, Sato C, Salehi-Rad S, Pfister K, Klein HE, St George-Hyslop PH. Novel PS1 mutation in a Bavarian kindred with familial Alzheimer disease. Alzheimer Disease and Associated Disorders. 18: 256-8. PMID 15592140  0.32
2004 Grasbon-Frodl E, Lorenz H, Mann U, Nitsch RM, Windl O, Kretzschmar HA. Loss of glycosylation associated with the T183A mutation in human prion disease. Acta Neuropathologica. 108: 476-84. PMID 15558291 DOI: 10.1007/s00401-004-0913-4  0.32
2004 Steinacker P, Mollenhauer B, Bibl M, Cepek L, Esselmann H, Brechlin P, Lewczuk P, Poser S, Kretzschmar HA, Wiltfang J, Trenkwalder C, Otto M. Heart fatty acid binding protein as a potential diagnostic marker for neurodegenerative diseases. Neuroscience Letters. 370: 36-9. PMID 15489013 DOI: 10.1016/j.neulet.2004.07.061  0.32
2004 Schüller U, Schober F, Kretzschmar HA, Herms J. Bcl-2 expression inversely correlates with tumour cell differentiation in medulloblastoma. Neuropathology and Applied Neurobiology. 30: 513-21. PMID 15488027 DOI: 10.1111/j.1365-2990.2004.00553.x  0.32
2004 Grasbon-Frodl E, Schmalzbauer R, Weber P, Krebs B, Windl O, Zerr I, Kretzschmar HA. A novel three extra-repeat insertion in the prion protein gene (PRNP) in a patient with Creutzfeldt-Jakob disease. Neurogenetics. 5: 249-50. PMID 15480878 DOI: 10.1007/s10048-004-0196-x  0.32
2004 Xiang W, Windl O, Wünsch G, Dugas M, Kohlmann A, Dierkes N, Westner IM, Kretzschmar HA. Identification of differentially expressed genes in scrapie-infected mouse brains by using global gene expression technology. Journal of Virology. 78: 11051-60. PMID 15452225 DOI: 10.1128/JVI.78.20.11051-11060.2004  0.32
2004 Steinhoff BJ, Zerr I, Glatting M, Schulz-Schaeffer W, Poser S, Kretzschmar HA. Diagnostic value of periodic complexes in Creutzfeldt-Jakob disease. Annals of Neurology. 56: 702-8. PMID 15449324 DOI: 10.1002/ana.20261  0.32
2004 Pocchiari M, Puopolo M, Croes EA, Budka H, Gelpi E, Collins S, Lewis V, Sutcliffe T, Guilivi A, Delasnerie-Laupretre N, Brandel JP, Alperovitch A, Zerr I, Poser S, Kretzschmar HA, et al. Predictors of survival in sporadic Creutzfeldt-Jakob disease and other human transmissible spongiform encephalopathies. Brain : a Journal of Neurology. 127: 2348-59. PMID 15361416 DOI: 10.1093/brain/awh249  0.32
2004 Meissner B, Körtner K, Bartl M, Jastrow U, Mollenhauer B, Schröter A, Finkenstaedt M, Windl O, Poser S, Kretzschmar HA, Zerr I. Sporadic Creutzfeldt-Jakob disease: magnetic resonance imaging and clinical findings. Neurology. 63: 450-6. PMID 15314808  0.32
2004 Harder A, Gregor A, Wirth T, Kreuz F, Schulz-Schaeffer WJ, Windl O, Plotkin M, Amthauer H, Neukirch K, Kretzschmar HA, Kuhlmann T, Braas R, Hahne HH, Jendroska K. Early age of onset in fatal familial insomnia. Two novel cases and review of the literature. Journal of Neurology. 251: 715-24. PMID 15311348 DOI: 10.1007/s00415-004-0409-0  0.32
2004 Petzold GC, Westner I, Bohner G, Einhäupl KM, Kretzschmar HA, Valdueza JM. False-positive pulvinar sign on MRI in sporadic Creutzfeldt-Jakob disease. Neurology. 62: 1235-6. PMID 15079042  0.32
2004 Otto M, Cepek L, Ratzka P, Doehlinger S, Boekhoff I, Wiltfang J, Irle E, Pergande G, Ellers-Lenz B, Windl O, Kretzschmar HA, Poser S, Prange H. Efficacy of flupirtine on cognitive function in patients with CJD: A double-blind study. Neurology. 62: 714-8. PMID 15007119  0.32
2004 Neumann M, Müller V, Görner K, Kretzschmar HA, Haass C, Kahle PJ. Pathological properties of the Parkinson's disease-associated protein DJ-1 in alpha-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick's disease. Acta Neuropathologica. 107: 489-96. PMID 14991385 DOI: 10.1007/s00401-004-0834-2  0.32
2004 Notari S, Capellari S, Giese A, Westner I, Baruzzi A, Ghetti B, Gambetti P, Kretzschmar HA, Parchi P. Effects of different experimental conditions on the PrPSc core generated by protease digestion: implications for strain typing and molecular classification of CJD. The Journal of Biological Chemistry. 279: 16797-804. PMID 14754888 DOI: 10.1074/jbc.M313220200  0.32
2004 Schmidt H, Otto M, Niedmann P, Cepek L, Schröter A, Kretzschmar HA, Poser S. CSF lactate dehydrogenase activity in patients with Creutzfeldt-Jakob disease exceeds that in other dementias. Dementia and Geriatric Cognitive Disorders. 17: 204-6. PMID 14739545 DOI: 10.1159/000076357  0.32
2004 Neumann M, Kretzschmar HA. Pathology and biochemistry of frontotemporal dementias | Pathologie und biochemie der frontotemporalen demenzen Nervenheilkunde. 23: 73-79.  0.32
2003 Korte S, Vassallo N, Kramer ML, Kretzschmar HA, Herms J. Modulation of L-type voltage-gated calcium channels by recombinant prion protein. Journal of Neurochemistry. 87: 1037-42. PMID 14622132 DOI: 10.1046/j.1471-4159.2003.02080.x  0.32
2003 Kretzschmar HA, Sethi S, Földvári Z, Windl O, Querner V, Zerr I, Poser S. Latrogenic Creutzfeldt-Jakob disease with florid plaques. Brain Pathology (Zurich, Switzerland). 13: 245-9. PMID 12946015  0.32
2003 Wiltfang J, Esselmann H, Smirnov A, Bibl M, Cepek L, Steinacker P, Mollenhauer B, Buerger K, Hampel H, Paul S, Neumann M, Maler M, Zerr I, Kornhuber J, Kretzschmar HA, et al. Beta-amyloid peptides in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease. Annals of Neurology. 54: 263-7. PMID 12891683 DOI: 10.1002/ana.10661  0.32
2003 Ratzka P, Döhlinger S, Cepek L, Steinacker P, Arlt S, Jacobi C, Schröter A, Wiltfang J, Prange H, Kretzschmar HA, Poser S, Otto M. Different binding pattern of antibodies to prion protein on lymphocytes from patients with sporadic Creutzfeldt-Jakob disease. Neuroscience Letters. 343: 29-32. PMID 12749990 DOI: 10.1016/S0304-3940(03)00315-X  0.32
2002 Neumann M, Kahle PJ, Giasson BI, Ozmen L, Borroni E, Spooren W, Müller V, Odoy S, Fujiwara H, Hasegawa M, Iwatsubo T, Trojanowski JQ, Kretzschmar HA, Haass C. Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies. The Journal of Clinical Investigation. 110: 1429-39. PMID 12438441 DOI: 10.1172/JCI15777  0.32
2002 Tschampa HJ, Herms JW, Schulz-Schaeffer WJ, Maruschak B, Windl O, Jastrow U, Zerr I, Steinhoff BJ, Poser S, Kretzschmar HA. Clinical findings in sporadic Creutzfeldt-Jakob disease correlate with thalamic pathology. Brain : a Journal of Neurology. 125: 2558-66. PMID 12390980  0.32
2002 Kahle PJ, Neumann M, Ozmen L, Muller V, Jacobsen H, Spooren W, Fuss B, Mallon B, Macklin WB, Fujiwara H, Hasegawa M, Iwatsubo T, Kretzschmar HA, Haass C. Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes. Embo Reports. 3: 583-8. PMID 12034752 DOI: 10.1093/embo-reports/kvf109  0.32
2002 Mollenhauer B, Zerr I, Ruge D, Krause G, Mehnert WH, Kretzschmar HA, Poser S. [Epidemiology and clinical symptomatology of Creutzfeldt-Jakob disease]. Deutsche Medizinische Wochenschrift (1946). 127: 312-7. PMID 11845386 DOI: 10.1055/s-2002-20150  0.32
2002 Otto M, Wiltfang J, Cepek L, Neumann M, Mollenhauer B, Steinacker P, Ciesielczyk B, Schulz-Schaeffer W, Kretzschmar HA, Poser S. Tau protein and 14-3-3 protein in the differential diagnosis of Creutzfeldt-Jakob disease. Neurology. 58: 192-7. PMID 11805244  0.32
2001 Schröder B, Franz B, Hempfling P, Selbert M, Jürgens T, Kretzschmar HA, Bodemer M, Poser S, Zerr I. Polymorphisms within the prion-like protein gene (Prnd) and their implications in human prion diseases, Alzheimer's disease and other neurological disorders. Human Genetics. 109: 319-25. PMID 11702213 DOI: 10.1007/s004390100591  0.32
2001 Neumann M, Schulz-Schaeffer W, Crowther RA, Smith MJ, Spillantini MG, Goedert M, Kretzschmar HA. Pick's disease associated with the novel Tau gene mutation K369I. Annals of Neurology. 50: 503-13. PMID 11601501 DOI: 10.1002/ana.1223  0.32
2001 Ratzka P, Schröter A, Cepek L, Henkel K, Wiltfang J, Kretzschmar HA, Prange H, Poser S, Otto M. Unaltered apoptotic behaviour of mononuclear cells from patients with sporadic Creutzfeldt-Jakob disease. Journal of Neurology. 248: 690-4. PMID 11569898  0.32
2001 Tschampa HJ, Neumann M, Zerr I, Henkel K, Schröter A, Schulz-Schaeffer WJ, Steinhoff BJ, Kretzschmar HA, Poser S. Patients with Alzheimer's disease and dementia with Lewy bodies mistaken for Creutzfeldt-Jakob disease. Journal of Neurology, Neurosurgery, and Psychiatry. 71: 33-9. PMID 11413259 DOI: 10.1136/jnnp.71.1.33  0.32
2001 Herms JW, Tings T, Dunker S, Kretzschmar HA. Prion protein affects Ca2+-activated K+ currents in cerebellar purkinje cells. Neurobiology of Disease. 8: 324-30. PMID 11300727 DOI: 10.1006/nbdi.2000.0369  0.32
2001 Papós M, Pekrun A, Herms JW, Behr TM, Meller J, Rustenbeck HH, Kretzschmar HA, Becker W. Somatostatin receptor scintigraphy in the management of cerebral malignant ectomesenchymoma: a case report. Pediatric Radiology. 31: 169-72. PMID 11297080 DOI: 10.1007/s002470000404  0.32
2001 Tschampa HJ, Schulz-Schaeffer W, Wiltfang J, Poser S, Otto M, Neumann M, Kretzschmar HA. Decreased CSF amyloid beta42 and normal tau levels in dementia with Lewy bodies. Neurology. 56: 576. PMID 11222819  0.32
2001 Augustin I, Korte S, Rickmann M, Kretzschmar HA, Südhof TC, Herms JW, Brose N. The cerebellum-specific Munc13 isoform Munc13-3 regulates cerebellar synaptic transmission and motor learning in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 10-7. PMID 11150314  0.32
2000 Post K, Brown DR, Groschup M, Kretzschmar HA, Riesner D. Neurotoxicity but not infectivity of prion proteins can be induced reversibly in vitro. Archives of Virology. Supplementum. 265-73. PMID 11214930  0.32
2000 Kretzschmar HA, Tings T, Madlung A, Giese A, Herms J. Function of PrP(C) as a copper-binding protein at the synapse. Archives of Virology. Supplementum. 239-49. PMID 11214928  0.32
2000 Giese A, Bieschke J, Eigen M, Kretzschmar HA. Putting prions into focus: application of single molecule detection to the diagnosis of prion diseases. Archives of Virology. Supplementum. 161-71. PMID 11214919  0.32
2000 Poser S, Zerr I, Schroeter A, Otto M, Giese A, Steinhoff BJ, Kretzschmar HA. Clinical and differential diagnosis of Creutzfeldt-Jakob disease. Archives of Virology. Supplementum. 153-9. PMID 11214918  0.32
2000 Herms J, Neidt I, Lüscher B, Sommer A, Schürmann P, Schröder T, Bergmann M, Wilken B, Probst-Cousin S, Hernáiz-Driever P, Behnke J, Hanefeld F, Pietsch T, Kretzschmar HA. C-MYC expression in medulloblastoma and its prognostic value. International Journal of Cancer. Journal International Du Cancer. 89: 395-402. PMID 11008200 DOI: 10.1002/1097-0215(20000920)89:5<395::AID-IJC1>3.0.CO;2-V  0.32
2000 Herms JW, Korte S, Gall S, Schneider I, Dunker S, Kretzschmar HA. Altered intracellular calcium homeostasis in cerebellar granule cells of prion protein-deficient mice. Journal of Neurochemistry. 75: 1487-92. PMID 10987828 DOI: 10.1046/j.1471-4159.2000.0751487.x  0.32
2000 Bleich S, Kropp S, Degner D, Zerr I, Pilz J, Gleiter CH, Otto M, Rüther E, Kretzschmar HA, Wiltfang J, Kornhuber J, Poser S. Creutzfeldt-Jakob disease and oxidative stress. Acta Neurologica Scandinavica. 101: 332-4. PMID 10987323 DOI: 10.1034/j.1600-0404.2000.9s290A.x  0.32
2000 Zerr I, Schulz-Schaeffer WJ, Giese A, Bodemer M, Schröter A, Henkel K, Tschampa HJ, Windl O, Pfahlberg A, Steinhoff BJ, Gefeller O, Kretzschmar HA, Poser S. Current clinical diagnosis in Creutzfeldt-Jakob disease: identification of uncommon variants. Annals of Neurology. 48: 323-9. PMID 10976638 DOI: 10.1002/1531-8249(200009)48:3<323::AID-ANA6>3.0.CO;2-5  0.32
2000 Parchi P, Zou W, Wang W, Brown P, Capellari S, Ghetti B, Kopp N, Schulz-Schaeffer WJ, Kretzschmar HA, Head MW, Ironside JW, Gambetti P, Chen SG. Genetic influence on the structural variations of the abnormal prion protein. Proceedings of the National Academy of Sciences of the United States of America. 97: 10168-72. PMID 10963679  0.32
2000 Qin K, Yang DS, Yang Y, Chishti MA, Meng LJ, Kretzschmar HA, Yip CM, Fraser PE, Westaway D. Copper(II)-induced conformational changes and protease resistance in recombinant and cellular PrP. Effect of protein age and deamidation. The Journal of Biological Chemistry. 275: 19121-31. PMID 10858456 DOI: 10.1074/jbc.275.25.19121  0.32
2000 Dürig J, Giese A, Schulz-Schaeffer W, Rosenthal C, Schmücker U, Bieschke J, Dührsen U, Kretzschmar HA. Differential constitutive and activation-dependent expression of prion protein in human peripheral blood leucocytes. British Journal of Haematology. 108: 488-95. PMID 10759704 DOI: 10.1046/j.1365-2141.2000.01881.x  0.32
2000 Otto M, Esselmann H, Schulz-Shaeffer W, Neumann M, Schröter A, Ratzka P, Cepek L, Zerr I, Steinacker P, Windl O, Kornhuber J, Kretzschmar HA, Poser S, Wiltfang J. Decreased beta-amyloid1-42 in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease. Neurology. 54: 1099-102. PMID 10720281  0.32
1999 Windl O, Giese A, Schulz-Schaeffer W, Zerr I, Skworc K, Arendt S, Oberdieck C, Bodemer M, Poser S, Kretzschmar HA. Molecular genetics of human prion diseases in Germany. Human Genetics. 105: 244-52. PMID 10987652 DOI: 10.1007/s004390051096  0.32
1999 Skworc KH, Windl O, Schulz-Schaeffer WJ, Giese A, Bergk J, Nägele A, Vieregge P, Zerr I, Poser S, Kretzschmar HA. Familial Creutzfeldt-Jakob disease with a novel 120-bp insertion in the prion protein gene. Annals of Neurology. 46: 693-700. PMID 10970246 DOI: 10.1002/1531-8249(199911)46:5<693::AID-ANA3>3.0.CO;2-Z  0.32
1999 Bürkle A, Kretzschmar HA, Brown DR. Poly(ADP-ribose) immunostaining to detect apoptosis induced by a neurotoxic fragment of prion protein. The Histochemical Journal. 31: 711-6. PMID 10646835  0.32
1999 Harder A, Jendroska K, Kreuz F, Wirth T, Schafranka C, Karnatz N, Théallier-Janko A, Dreier J, Lohan K, Emmerich D, Cervós-Navarro J, Windl O, Kretzschmar HA, Nürnberg P, Witkowski R. Novel twelve-generation kindred of fatal familial insomnia from germany representing the entire spectrum of disease expression. American Journal of Medical Genetics. 87: 311-6. PMID 10588836 DOI: 10.1002/(SICI)1096-8628(19991203)87:4<311::AID-AJMG6>3.0.CO;2-5  0.32
1999 Wiltfang J, Otto M, Baxter HC, Bodemer M, Steinacker P, Bahn E, Zerr I, Kornhuber J, Kretzschmar HA, Poser S, Rüther E, Aitken A. Isoform pattern of 14-3-3 proteins in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease. Journal of Neurochemistry. 73: 2485-90. PMID 10582609 DOI: 10.1046/j.1471-4159.1999.0732485.x  0.32
1999 Poser S, Mollenhauer B, Kraubeta A, Zerr I, Steinhoff BJ, Schroeter A, Finkenstaedt M, Schulz-Schaeffer WJ, Kretzschmar HA, Felgenhauer K. How to improve the clinical diagnosis of Creutzfeldt-Jakob disease. Brain : a Journal of Neurology. 122: 2345-51. PMID 10581227 DOI: 10.1093/brain/122.12.2345  0.32
1999 Herms JW, von Loewenich FD, Behnke J, Markakis E, Kretzschmar HA. c-myc oncogene family expression in glioblastoma and survival. Surgical Neurology. 51: 536-42. PMID 10321885 DOI: 10.1016/S0090-3019(98)00028-7  0.32
1999 Kropp S, Zerr I, Schulz-Schaeffer WJ, Riedemann C, Bodemer M, Laske C, Kretzschmar HA, Poser S. Increase of neuron-specific enolase in patients with Creutzfeldt-Jakob disease. Neuroscience Letters. 261: 124-6. PMID 10081943 DOI: 10.1016/S0304-3940(98)00992-6  0.32
1999 Kropp S, Schulz-Schaeffer WJ, Finkenstaedt M, Riedemann C, Windl O, Steinhoff BJ, Zerr I, Kretzschmar HA, Poser S. The Heidenhain variant of Creutzfeldt-Jakob disease. Archives of Neurology. 56: 55-61. PMID 9923761 DOI: 10.1001/archneur.56.1.55  0.32
1998 Zerr I, Giese A, Windl O, Kropp S, Schulz-Schaeffer W, Riedemann C, Skworc K, Bodemer M, Kretzschmar HA, Poser S. Phenotypic variability in fatal familial insomnia (D178N-129M) genotype. Neurology. 51: 1398-405. PMID 9818868  0.32
1998 Giese A, Brown DR, Groschup MH, Feldmann C, Haist I, Kretzschmar HA. Role of microglia in neuronal cell death in prion disease. Brain Pathology (Zurich, Switzerland). 8: 449-57. PMID 9669696  0.32
1998 Brown DR, Schmidt B, Kretzschmar HA. A prion protein fragment primes type 1 astrocytes to proliferation signals from microglia. Neurobiology of Disease. 4: 410-22. PMID 9666480 DOI: 10.1006/nbdi.1998.0169  0.32
1998 Brown DR, Besinger A, Herms JW, Kretzschmar HA. Microglial expression of the prion protein. Neuroreport. 9: 1425-9. PMID 9631441  0.32
1998 Brown DR, Kretzschmar HA. The glio-toxic mechanism of alpha-aminoadipic acid on cultured astrocytes. Journal of Neurocytology. 27: 109-18. PMID 9609401  0.32
1998 Brown DR, Schmidt B, Kretzschmar HA. Prion protein fragment interacts with PrP-deficient cells. Journal of Neuroscience Research. 52: 260-7. PMID 9590434 DOI: 10.1002/(SICI)1097-4547(19980501)52:3<260::AID-JNR2>3.0.CO;2-B  0.32
1998 Brown DR, Schmidt B, Kretzschmar HA. Effects of copper on survival of prion protein knockout neurons and glia. Journal of Neurochemistry. 70: 1686-93. PMID 9523587  0.32
1998 Brown DR, Schmidt B, Groschup MH, Kretzschmar HA. Prion protein expression in muscle cells and toxicity of a prion protein fragment. European Journal of Cell Biology. 75: 29-37. PMID 9523152 DOI: 10.1016/S0171-9335(98)80043-5  0.32
1998 Otto M, Wiltfang J, Schütz E, Zerr I, Otto A, Pfahlberg A, Gefeller O, Uhr M, Giese A, Weber T, Kretzschmar HA, Poser S. Diagnosis of Creutzfeldt-Jakob disease by measurement of S100 protein in serum: prospective case-control study. Bmj (Clinical Research Ed.). 316: 577-82. PMID 9518907  0.32
1998 Zerr I, Bodemer M, Gefeller O, Otto M, Poser S, Wiltfang J, Windl O, Kretzschmar HA, Weber T. Detection of 14-3-3 protein in the cerebrospinal fluid supports the diagnosis of Creutzfeldt-Jakob disease. Annals of Neurology. 43: 32-40. PMID 9450766 DOI: 10.1002/ana.410430109  0.32
1997 Brown DR, Schmidt B, Kretzschmar HA. Effects of oxidative stress on prion protein expression in PC12 cells. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 15: 961-72. PMID 9641527  0.32
1997 Herms JW, Behnke J, Bergmann M, Christen HJ, Kolb R, Wilkening M, Markakis E, Hanefeld F, Kretzschmar HA. Potential prognostic value of C-erbB-2 expression in medulloblastomas in very young children. Journal of Pediatric Hematology/Oncology. 19: 510-5. PMID 9407936 DOI: 10.1097/00043426-199711000-00004  0.32
1997 Otto M, Stein H, Szudra A, Zerr I, Bodemer M, Gefeller O, Poser S, Kretzschmar HA, Mäder M, Weber T. S-100 protein concentration in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease. Journal of Neurology. 244: 566-70. PMID 9352454 DOI: 10.1007/s004150050145  0.32
1997 Weiss S, Proske D, Neumann M, Groschup MH, Kretzschmar HA, Famulok M, Winnacker EL. RNA aptamers specifically interact with the prion protein PrP. Journal of Virology. 71: 8790-7. PMID 9343239  0.32
1997 Poser S, Zerr I, Schulz-Schaeffer WJ, Kretzschmar HA, Felgenhauer K. [The Creutzfeld-Jakob disease. A sphinx of current neurobiology]. Deutsche Medizinische Wochenschrift (1946). 122: 1099-105. PMID 9340249 DOI: 10.1055/s-2008-1047733  0.32
1997 Herms JW, Madlung A, Brown DR, Kretzschmar HA. Increase of intracellular free Ca2+ in microglia activated by prion protein fragment. Glia. 21: 253-7. PMID 9336239 DOI: 10.1002/(SICI)1098-1136(199710)21:2<253::AID-GLIA8>3.0.CO;2-7  0.32
1997 Brown DR, Schulz-Schaeffer WJ, Schmidt B, Kretzschmar HA. Prion protein-deficient cells show altered response to oxidative stress due to decreased SOD-1 activity. Experimental Neurology. 146: 104-12. PMID 9225743 DOI: 10.1006/exnr.1997.6505  0.32
1997 Brown DR, Kretzschmar HA. Microglia and prion disease: a review. Histology and Histopathology. 12: 883-92. PMID 9225170 DOI: 10.1002/jemt.1122  1
1997 Brown DR, Herms JW, Schmidt B, Kretzschmar HA. PrP and beta-amyloid fragments activate different neurotoxic mechanisms in cultured mouse cells. The European Journal of Neuroscience. 9: 1162-9. PMID 9215699  0.32
1997 Otto M, Wiltfang J, Tumani H, Zerr I, Lantsch M, Kornhuber J, Weber T, Kretzschmar HA, Poser S. Elevated levels of tau-protein in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease. Neuroscience Letters. 225: 210-2. PMID 9147407 DOI: 10.1016/S0304-3940(97)00215-2  0.32
1997 Kretzschmar HA, Giese A, Brown DR, Herms J, Keller B, Schmidt B, Groschup M. Cell death in prion disease. Journal of Neural Transmission. Supplementum. 50: 191-210. PMID 9120419  0.32
1996 Kohlhase J, Schuh R, Dowe G, Kühnlein RP, Jäckle H, Schroeder B, Schulz-Schaeffer W, Kretzschmar HA, Köhler A, Müller U, Raab-Vetter M, Burkhardt E, Engel W, Stick R. Isolation, characterization, and organ-specific expression of two novel human zinc finger genes related to the Drosophila gene spalt. Genomics. 38: 291-8. PMID 8975705 DOI: 10.1006/geno.1996.0631  0.32
1996 Brown DR, Schmidt B, Kretzschmar HA. A neurotoxic prion protein fragment enhances proliferation of microglia but not astrocytes in culture. Glia. 18: 59-67. PMID 8891692 DOI: 10.1002/(SICI)1098-1136(199609)18:1<59::AID-GLIA6>3.0.CO;2-Z  0.32
1996 Zerr I, Bodemer M, Otto M, Poser S, Windl O, Kretzschmar HA, Gefeller O, Weber T. Diagnosis of Creutzfeldt-Jakob disease by two-dimensional gel electrophoresis of cerebrospinal fluid. Lancet. 348: 846-9. PMID 8826809 DOI: 10.1016/S0140-6736(96)08077-4  0.32
1996 Budka H, Aguzzi A, Brown P, Brucher JM, Bugiani O, Collinge J, Diringer H, Gullotta F, Haltia M, Hauw JJ, Ironside JW, Kretzschmar HA, Lantos PL, Masullo C, Pocchiari M, et al. [Consensus report: tissue handling in suspected Creutzfeldt-Jakob disease and other spongiform encephalopathies (prion diseases) in the human. European Union Biomed-1 Concerted Action]. Der Pathologe. 17: 171-5. PMID 8650149  0.32
1996 Brown DR, Schmidt B, Kretzschmar HA. Role of microglia and host prion protein in neurotoxicity of a prion protein fragment. Nature. 380: 345-7. PMID 8598929 DOI: 10.1038/380345a0  0.32
1995 Zerr I, Bodemer M, Räcker S, Grosche S, Poser S, Kretzschmar HA, Weber T. Cerebrospinal fluid concentration of neuron-specific enolase in diagnosis of Creutzfeldt-Jakob disease. Lancet. 345: 1609-10. PMID 7783539 DOI: 10.1016/S0140-6736(95)90118-3  0.32
1995 Brown DR, Kretzschmar HA. Topographical reinnervation of the toad glutaeus muscle by axons of only one spinal nerve. Neuroreport. 6: 989-93. PMID 7632906  0.32
1994 Weber T, Turner RW, Frye S, Lüke W, Kretzschmar HA, Lüer W, Hunsmann G. Progressive multifocal leukoencephalopathy diagnosed by amplification of JC virus-specific DNA from cerebrospinal fluid. Aids (London, England). 8: 49-57. PMID 8011236  0.32
1994 Brown DR, Herms J, Kretzschmar HA. Mouse cortical cells lacking cellular PrP survive in culture with a neurotoxic PrP fragment. Neuroreport. 5: 2057-60. PMID 7865744  0.32
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