Tsung-Yu Chen - Publications

University of California, Davis, Davis, CA 

57 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Nguyen DM, Chen TY. Structure and Function of Calcium-Activated Chloride Channels and Phospholipid Scramblases in the TMEM16 Family. Handbook of Experimental Pharmacology. PMID 35792944 DOI: 10.1007/164_2022_595  0.375
2022 Kwon HC, Fairclough RH, Chen TY. Biophysical and Pharmacological Insights to CLC Chloride Channels. Handbook of Experimental Pharmacology. PMID 35768555 DOI: 10.1007/164_2022_594  0.443
2021 Fu SJ, Hu MC, Hsiao CT, Cheng AT, Chen TY, Jeng CJ, Tang CY. Regulation of ClC-2 Chloride Channel Proteostasis by Molecular Chaperones: Correction of Leukodystrophy-Associated Defect. International Journal of Molecular Sciences. 22. PMID 34070744 DOI: 10.3390/ijms22115859  0.369
2021 Nguyen DM, Kwon HC, Chen TY. Divalent Cation Modulation of Ion Permeation in TMEM16 Proteins. International Journal of Molecular Sciences. 22. PMID 33672260 DOI: 10.3390/ijms22042209  0.34
2020 Kwon HC, Yu Y, Fairclough RH, Chen TY. Proton-dependent inhibition, inverted voltage activation, and slow gating of CLC-0 Chloride Channel. Plos One. 15: e0240704. PMID 33362212 DOI: 10.1371/journal.pone.0240704  0.538
2020 Fu SJ, Hu MC, Peng YJ, Fang HY, Hsiao CT, Chen TY, Jeng CJ, Tang CY. CUL4-DDB1-CRBN E3 Ubiquitin Ligase Regulates Proteostasis of ClC-2 Chloride Channels: Implication for Aldosteronism and Leukodystrophy. Cells. 9. PMID 32466489 DOI: 10.3390/cells9061332  0.447
2020 Nguyen DM, Chen LS, Jeng G, Yu WP, Chen TY. Cobalt ion interaction with TMEM16A calcium-activated chloride channel: Inhibition and potentiation. Plos One. 15: e0231812. PMID 32302365 DOI: 10.1371/Journal.Pone.0231812  0.628
2020 Jeng CJ, Fu SJ, You CY, Peng YJ, Hsiao CT, Chen TY, Tang CY. Defective Gating and Proteostasis of Human ClC-1 Chloride Channel: Molecular Pathophysiology of Myotonia Congenita. Frontiers in Neurology. 11: 76. PMID 32117034 DOI: 10.3389/fneur.2020.00076  0.46
2019 Nguyen DM, Chen LS, Yu WP, Chen TY. Comparison of ion transport determinants between a TMEM16 chloride channel and phospholipid scramblase. The Journal of General Physiology. PMID 30670476 DOI: 10.1085/jgp.201812270  0.65
2018 Peng YJ, Lee YC, Fu SJ, Chien YC, Liao YF, Chen TY, Jeng CJ, Tang CY. FKBP8 Enhances Protein Stability of the CLC-1 Chloride Channel at the Plasma Membrane. International Journal of Molecular Sciences. 19. PMID 30487393 DOI: 10.3390/ijms19123783  0.395
2018 Nguyen DM, Chen LS, Yu W, Chen T. Comparing Ion Transport between a Chloride Channel and a Phospholipid Scramblase in the TMEM16 Family Biophysical Journal. 114. DOI: 10.1016/J.Bpj.2017.11.733  0.633
2017 O'Halloran DM, Altshuler-Keylin S, Zhang XD, He C, Morales-Phan C, Yu Y, Kaye JA, Brueggemann C, Chen TY, L'Etoile ND. Contribution of the cyclic nucleotide gated channel subunit, CNG-3, to olfactory plasticity in Caenorhabditis elegans. Scientific Reports. 7: 169. PMID 28279024 DOI: 10.1038/S41598-017-00126-7  0.375
2016 Jeng G, Aggarwal M, Yu WP, Chen TY. Independent activation of distinct pores in dimeric TMEM16A channels. The Journal of General Physiology. 148: 393-404. PMID 27799319 DOI: 10.1085/jgp.201611651  0.695
2016 Peng YJ, Huang JJ, Wu HH, Hsieh HY, Wu CY, Chen SC, Chen TY, Tang CY. Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β. Scientific Reports. 6: 32444. PMID 27580824 DOI: 10.1038/srep32444  0.391
2016 Pedersen TH, Riisager A, de Paoli FV, Chen TY, Nielsen OB. Role of physiological ClC-1 Cl- ion channel regulation for the excitability and function of working skeletal muscle. The Journal of General Physiology. 147: 291-308. PMID 27022190 DOI: 10.1085/jgp.201611582  0.384
2016 Riisager A, de Paoli FV, Yu WP, Pedersen TH, Chen TY, Nielsen OB. Protein kinase C dependent regulation of ClC-1 channels in active human muscle and its effect on fast and slow gating. The Journal of Physiology. PMID 26857341 DOI: 10.1113/JP271556  0.594
2016 Jeng G, Aggarwal M, Yu W, Chen T. Activating Individual Subunits of TMEM16A Calcium-Activated Chloride Channels Biophysical Journal. 110. DOI: 10.1016/J.Bpj.2015.11.1571  0.697
2015 Yu Y, Tsai MF, Yu WP, Chen TY. Modulation of the slow/common gating of CLC channels by intracellular cadmium. The Journal of General Physiology. 146: 495-508. PMID 26621774 DOI: 10.1085/jgp.201511413  0.754
2015 Chen YA, Peng YJ, Hu MC, Huang JJ, Chien YC, Wu JT, Chen TY, Tang CY. The Cullin 4A/B-DDB1-Cereblon E3 Ubiquitin Ligase Complex Mediates the Degradation of CLC-1 Chloride Channels. Scientific Reports. 5: 10667. PMID 26021757 DOI: 10.1038/srep10667  0.526
2015 Yu Y, Chen TY. Purified human brain calmodulin does not alter the bicarbonate permeability of the ANO1/TMEM16A channel. The Journal of General Physiology. 145: 79-81. PMID 25548138 DOI: 10.1085/jgp.201411294  0.463
2014 Yu Y, Kuan AS, Chen TY. Calcium-calmodulin does not alter the anion permeability of the mouse TMEM16A calcium-activated chloride channel. The Journal of General Physiology. 144: 115-24. PMID 24981232 DOI: 10.1085/jgp.201411179  0.584
2014 Ni YL, Kuan AS, Chen TY. Activation and inhibition of TMEM16A calcium-activated chloride channels. Plos One. 9: e86734. PMID 24489780 DOI: 10.1371/journal.pone.0086734  0.618
2014 Kuan A, Ni Y, Chen T. Electrophysiological Properties of TMEM16A Calcium-Activated Chloride Channels Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.838  0.602
2013 Lee TT, Zhang XD, Chuang CC, Chen JJ, Chen YA, Chen SC, Chen TY, Tang CY. Myotonia congenita mutation enhances the degradation of human CLC-1 chloride channels. Plos One. 8: e55930. PMID 23424641 DOI: 10.1371/journal.pone.0055930  0.528
2012 Chen TY. Single myotonia mutation strikes multiple mechanisms of a chloride channel. The Journal of Physiology. 590: 3407. PMID 22855049 DOI: 10.1113/jphysiol.2012.238337  0.464
2012 Richman DP, Yu Y, Lee TT, Tseng PY, Yu WP, Maselli RA, Tang CY, Chen TY. Dominantly inherited myotonia congenita resulting from a mutation that increases open probability of the muscle chloride channel CLC-1. Neuromolecular Medicine. 14: 328-37. PMID 22790975 DOI: 10.1007/S12017-012-8190-1  0.68
2012 Bennetts B, Yu Y, Chen TY, Parker MW. Intracellular β-nicotinamide adenine dinucleotide inhibits the skeletal muscle ClC-1 chloride channel. The Journal of Biological Chemistry. 287: 25808-20. PMID 22689570 DOI: 10.1074/jbc.M111.327551  0.574
2012 Yu T, Wang XQ, Sang JP, Pan CX, Zou XW, Chen TY, Zou X. Influences of mutations on the electrostatic binding free energies of chloride ions in Escherichia coli ClC. The Journal of Physical Chemistry. B. 116: 6431-8. PMID 22612693 DOI: 10.1021/jp300430f  0.412
2012 Yu Y, Yu W, Chen T. Inhibition of a Dimer Interface Mutant of CLC-0 by Intracellular Cadmium Ion Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.1823  0.712
2011 Tang CY, Chen TY. Physiology and pathophysiology of CLC-1: mechanisms of a chloride channel disease, myotonia. Journal of Biomedicine & Biotechnology. 2011: 685328. PMID 22187529 DOI: 10.1155/2011/685328  0.577
2011 Tseng PY, Yu WP, Liu HY, Zhang XD, Zou X, Chen TY. Binding of ATP to the CBS domains in the C-terminal region of CLC-1. The Journal of General Physiology. 137: 357-68. PMID 21444658 DOI: 10.1085/jgp.201010495  0.537
2010 Wang XQ, Yu T, Sang JP, Zou XW, Chen TY, Bolser D, Zou X. A three-state multi-ion kinetic model for conduction properties of ClC-0 chloride channel. Biophysical Journal. 99: 464-71. PMID 20643064 DOI: 10.1016/j.bpj.2010.04.047  0.435
2010 Zhang XD, Yu WP, Chen TY. Accessibility of the CLC-0 pore to charged methanethiosulfonate reagents. Biophysical Journal. 98: 377-85. PMID 20141750 DOI: 10.1016/j.bpj.2009.09.066  0.558
2010 Tseng P, Chen T. Analysis of the CLC-1 ATP Binding Site by Structure-Guided Mutagenesis Biophysical Journal. 98: 320a. DOI: 10.1016/J.Bpj.2009.12.1739  0.506
2010 Zhang X, Yu W, Chen T. The Preference of the CLC-0 Pore for Charged Methanethiosulfonate Reagents Biophysical Journal. 98. DOI: 10.1016/J.Bpj.2009.12.1733  0.602
2009 Zhang XD, Chen TY. Amphiphilic blockers punch through a mutant CLC-0 pore. The Journal of General Physiology. 133: 59-68. PMID 19088382 DOI: 10.1085/jgp.200810005  0.392
2009 Zhang XD, Tseng PY, Yu WP, Chen TY. Blocking pore-open mutants of CLC-0 by amphiphilic blockers. The Journal of General Physiology. 133: 43-58. PMID 19088381 DOI: 10.1085/jgp.200810004  0.67
2008 Zhang XD, Tseng PY, Chen TY. ATP inhibition of CLC-1 is controlled by oxidation and reduction. The Journal of General Physiology. 132: 421-8. PMID 18824589 DOI: 10.1085/jgp.200810023  0.408
2008 Chen TY, Hwang TC. CLC-0 and CFTR: chloride channels evolved from transporters. Physiological Reviews. 88: 351-87. PMID 18391167 DOI: 10.1152/physrev.00058.2006  0.521
2007 Tseng PY, Bennetts B, Chen TY. Cytoplasmic ATP inhibition of CLC-1 is enhanced by low pH. The Journal of General Physiology. 130: 217-21. PMID 17664348 DOI: 10.1085/jgp.200709817  0.511
2006 Bykova EA, Zhang XD, Chen TY, Zheng J. Large movement in the C terminus of CLC-0 chloride channel during slow gating. Nature Structural & Molecular Biology. 13: 1115-9. PMID 17115052 DOI: 10.1038/nsmb1176  0.484
2006 Chen TY, Takeuchi H, Kurahashi T. Odorant inhibition of the olfactory cyclic nucleotide-gated channel with a native molecular assembly. The Journal of General Physiology. 128: 365-71. PMID 16940558 DOI: 10.1085/Jgp.200609577  0.617
2006 Zhang XD, Li Y, Yu WP, Chen TY. Roles of K149, G352, and H401 in the channel functions of ClC-0: testing the predictions from theoretical calculations. The Journal of General Physiology. 127: 435-47. PMID 16567465 DOI: 10.1085/jgp.200509460  0.719
2005 Li Y, Yu WP, Lin CW, Chen TY. Oxidation and reduction control of the inactivation gating of Torpedo ClC-0 chloride channels. Biophysical Journal. 88: 3936-45. PMID 15778445 DOI: 10.1529/biophysj.104.055012  0.734
2005 Chen TY. Structure and function of clc channels. Annual Review of Physiology. 67: 809-39. PMID 15709979 DOI: 10.1146/annurev.physiol.67.032003.153012  0.578
2003 Chen TY, Chen MF, Lin CW. Electrostatic control and chloride regulation of the fast gating of ClC-0 chloride channels. The Journal of General Physiology. 122: 641-51. PMID 14581587 DOI: 10.1085/jgp.200308846  0.719
2003 Lin CW, Chen TY. Probing the pore of ClC-0 by substituted cysteine accessibility method using methane thiosulfonate reagents. The Journal of General Physiology. 122: 147-59. PMID 12885876 DOI: 10.1085/jgp.200308845  0.722
2003 Chen MF, Chen TY. Side-chain charge effects and conductance determinants in the pore of ClC-0 chloride channels. The Journal of General Physiology. 122: 133-45. PMID 12885875 DOI: 10.1085/jgp.200308844  0.585
2003 Chen TY. Coupling gating with ion permeation in ClC channels. Science's Stke : Signal Transduction Knowledge Environment. 2003: pe23. PMID 12824475 DOI: 10.1126/stke.2003.188.pe23  0.617
2001 Chen MF, Chen TY. Different fast-gate regulation by external Cl- and H+ of the muscle-type ClC chloride channels Journal of General Physiology. 118: 23-32. PMID 11429442 DOI: 10.1085/jgp.118.1.23  0.469
2000 Lin CW, Chen TY. Cysteine modification of a putative pore residue in ClC-0: implication for the pore stoichiometry of ClC chloride channels. The Journal of General Physiology. 116: 535-46. PMID 11004203 DOI: 10.1085/jgp.116.4.535  0.631
1999 Lin YW, Lin CW, Chen TY. Elimination of the slow gating of ClC-0 chloride channel by a point mutation. The Journal of General Physiology. 114: 1-12. PMID 10398688 DOI: 10.1085/JGP.114.1.1  0.617
1998 Chen TY. Extracellular zinc ion inhibits ClC-0 chloride channels by facilitating slow gating Journal of General Physiology. 112: 715-726. PMID 9834141 DOI: 10.1085/jgp.112.6.715  0.538
1996 Chen TY, Miller C. Nonequilibrium gating and voltage dependence of the ClC-0 Cl- channel. The Journal of General Physiology. 108: 237-50. PMID 8894974 DOI: 10.1085/Jgp.108.4.237  0.647
1994 Yellen G, Sodickson D, Chen TY, Jurman ME. An engineered cysteine in the external mouth of a K+ channel allows inactivation to be modulated by metal binding. Biophysical Journal. 66: 1068-75. PMID 8038379 DOI: 10.1016/S0006-3495(94)80888-4  0.721
1994 Chen TY, Yau KW. Direct modulation by Ca(2+)-calmodulin of cyclic nucleotide-activated channel of rat olfactory receptor neurons. Nature. 368: 545-8. PMID 7511217 DOI: 10.1038/368545a0  0.635
1990 Chiu TH, Chen TY, Ho CL, Chiang ST. Electrophysiological effects of dermorphin on locus coeruleus neurons of rat Neuropharmacology. 29: 747-755. PMID 1980348 DOI: 10.1016/0028-3908(90)90128-E  0.309
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