Dimitri Krainc - Publications

Affiliations: 
Northwestern University, Evanston, IL 
Area:
Cell Biology, Disease, Molecular Neuroscience, Neurobiology of Disease

44 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

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Year Citation  Score
2021 Kim S, Wong YC, Gao F, Krainc D. Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson's disease. Nature Communications. 12: 1807. PMID 33753743 DOI: 10.1038/s41467-021-22113-3  0.52
2021 Charif M, Wong YC, Kim S, Guichet A, Vignal C, Zanlonghi X, Bensaid P, Procaccio V, Bonneau D, Amati-Bonneau P, Reynier P, Krainc D, Lenaers G. Dominant mutations in MIEF1 affect mitochondrial dynamics and cause a singular late onset optic neuropathy. Molecular Neurodegeneration. 16: 12. PMID 33632269 DOI: 10.1186/s13024-021-00431-w  0.52
2021 Burbulla LF, Mc Donald JM, Valdez C, Gao F, Bigio EH, Krainc D. Modeling Brain Pathology of Niemann-Pick Disease Type C Using Patient-Derived Neurons. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 33438272 DOI: 10.1002/mds.28463  0.52
2020 Minakaki G, Krainc D, Burbulla LF. The Convergence of Alpha-Synuclein, Mitochondrial, and Lysosomal Pathways in Vulnerability of Midbrain Dopaminergic Neurons in Parkinson's Disease. Frontiers in Cell and Developmental Biology. 8: 580634. PMID 33381501 DOI: 10.3389/fcell.2020.580634  0.36
2020 Godbe JM, Freeman R, Burbulla LF, Lewis J, Krainc D, Stupp SI. Gelator length precisely tunes supramolecular hydrogel stiffness and neuronal phenotype in 3D culture. Acs Biomaterials Science & Engineering. 6: 1196-1207. PMID 33094153 DOI: 10.1021/acsbiomaterials.9b01585  0.36
2020 Boussaad I, Obermaier CD, Hanss Z, Bobbili DR, Bolognin S, Glaab E, Wołyńska K, Weisschuh N, De Conti L, May C, Giesert F, Grossmann D, Lambert A, Kirchen S, Biryukov M, ... ... Krainc D, et al. A patient-based model of RNA mis-splicing uncovers treatment targets in Parkinson's disease. Science Translational Medicine. 12. PMID 32908004 DOI: 10.1126/scitranslmed.aau3960  0.4
2020 Peng W, Wong YC, Krainc D. Mitochondria-lysosome contacts regulate mitochondrial Ca dynamics via lysosomal TRPML1. Proceedings of the National Academy of Sciences of the United States of America. PMID 32703809 DOI: 10.1073/pnas.2003236117  0.52
2020 Graves SM, Xie Z, Stout KA, Zampese E, Burbulla LF, Shih JC, Kondapalli J, Patriarchi T, Tian L, Brichta L, Greengard P, Krainc D, Schumacker PT, Surmeier DJ. Author Correction: Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain. Nature Neuroscience. PMID 31911656 DOI: 10.1038/s41593-019-0583-0  0.36
2020 Marotta N, Kim S, Krainc D. Organoid and pluripotent stem cells in Parkinson's disease modeling: an expert view on their value to drug discovery. Expert Opinion On Drug Discovery. 1-15. PMID 31899983 DOI: 10.1080/17460441.2020.1703671  0.52
2019 Graves SM, Xie Z, Stout KA, Zampese E, Burbulla LF, Shih JC, Kondapalli J, Patriarchi T, Tian L, Brichta L, Greengard P, Krainc D, Schumacker PT, Surmeier DJ. Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain. Nature Neuroscience. PMID 31844313 DOI: 10.1038/s41593-019-0556-3  0.36
2019 Burbulla LF, Jeon S, Zheng J, Song P, Silverman RB, Krainc D. A modulator of wild-type glucocerebrosidase improves pathogenic phenotypes in dopaminergic neuronal models of Parkinson's disease. Science Translational Medicine. 11. PMID 31619543 DOI: 10.1126/scitranslmed.aau6870  0.36
2019 Wong YC, Luk K, Purtell K, Burke Nanni S, Stoessl AJ, Trudeau LE, Yue Z, Krainc D, Oertel W, Obeso JA, Volpicelli-Daley LA. Neuronal vulnerability in Parkinson disease: Should the focus be on axons and synaptic terminals? Movement Disorders : Official Journal of the Movement Disorder Society. PMID 31483900 DOI: 10.1002/mds.27823  0.52
2019 Burbulla LF, Krainc D. The role of dopamine in the pathogenesis of GBA1-linked Parkinson's disease. Neurobiology of Disease. 132: 104545. PMID 31351996 DOI: 10.1016/j.nbd.2019.104545  0.36
2019 Wong YC, Peng W, Krainc D. Lysosomal Regulation of Inter-mitochondrial Contact Fate and Motility in Charcot-Marie-Tooth Type 2. Developmental Cell. PMID 31231042 DOI: 10.1016/j.devcel.2019.05.033  0.52
2019 Tsunemi T, Perez-Rosello T, Ishiguro Y, Yoroisaka A, Jeon S, Hamada K, Krishna Vangipuram Suresh M, Wong YC, Xie Z, Akamatsu W, Mazzulli JR, Surmeier DJ, Hattori N, Krainc D. Increased lysosomal exocytosis induced by lysosomal Ca channel agonists protects human dopaminergic neurons from α-synuclein toxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31097622 DOI: 10.1523/JNEUROSCI.3085-18.2019  0.52
2019 Wong YC, Kim S, Peng W, Krainc D. Regulation and Function of Mitochondria-Lysosome Membrane Contact Sites in Cellular Homeostasis. Trends in Cell Biology. PMID 30898429 DOI: 10.1016/j.tcb.2019.02.004  0.52
2019 Zheng J, Jeon S, Jiang W, Burbulla LF, Ysselstein D, Oevel K, Krainc D, Silverman RB. Correction to Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase. Journal of Medicinal Chemistry. PMID 30793892 DOI: 10.1021/acs.jmedchem.9b00284  0.36
2019 Zheng J, Jeon S, Jiang W, Burbulla LF, Ysselstein D, Oevel K, Krainc D, Silverman RB. Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase. Journal of Medicinal Chemistry. PMID 30645117 DOI: 10.1021/acs.jmedchem.8b01294  0.36
2018 Nguyen M, Wong YC, Ysselstein D, Severino A, Krainc D. Synaptic, Mitochondrial, and Lysosomal Dysfunction in Parkinson's Disease. Trends in Neurosciences. PMID 30509690 DOI: 10.1016/j.tins.2018.11.001  0.52
2018 Seibler P, Burbulla LF, Dulovic M, Zittel S, Heine J, Schmidt T, Rudolph F, Westenberger A, Rakovic A, Münchau A, Krainc D, Klein C. Iron overload is accompanied by mitochondrial and lysosomal dysfunction in WDR45 mutant cells. Brain : a Journal of Neurology. PMID 30169597 DOI: 10.1093/brain/awy230  0.4
2018 Kim MJ, Jeon S, Burbulla LF, Krainc D. Acid ceramidase inhibition ameliorates α-synuclein accumulation upon loss of GBA1 function. Human Molecular Genetics. PMID 29579237 DOI: 10.1093/hmg/ddy105  0.36
2018 Wong YC, Ysselstein D, Krainc D. Mitochondria-lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis. Nature. PMID 29364868 DOI: 10.1038/nature25486  0.52
2017 Valdez C, Wong YC, Schwake M, Bu G, Wszolek ZK, Krainc D. Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients. Human Molecular Genetics. PMID 29036611 DOI: 10.1093/hmg/ddx364  0.52
2017 Shamir R, Klein C, Amar D, Vollstedt EJ, Bonin M, Usenovic M, Wong YC, Maver A, Poths S, Safer H, Corvol JC, Lesage S, Lavi O, Deuschl G, Kuhlenbaeumer G, ... ... Krainc D, et al. Analysis of blood-based gene expression in idiopathic Parkinson disease. Neurology. PMID 28916538 DOI: 10.1212/WNL.0000000000004516  0.52
2017 Burbulla LF, Song P, Mazzulli JR, Zampese E, Wong YC, Jeon S, Santos DP, Blanz J, Obermaier CD, Strojny C, Savas JN, Kiskinis E, Zhuang X, Krüger R, Surmeier DJ, ... Krainc D, et al. Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease. Science (New York, N.Y.). PMID 28882997 DOI: 10.1126/science.aam9080  0.52
2017 Wong YC, Krainc D. α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies. Nature Medicine. 23: 1-13. PMID 28170377 DOI: 10.1038/nm.4269  0.52
2017 Kim MJ, Deng HX, Wong YC, Siddique T, Krainc D. The Parkinson's disease-linked protein TMEM230 is required for Rab8a-mediated secretory vesicle trafficking and retromer trafficking. Human Molecular Genetics. PMID 28115417 DOI: 10.1093/hmg/ddw413  0.52
2016 Wong YC, Krainc D. Lysosomal trafficking defects link Parkinson's disease with Gaucher's disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 27619775 DOI: 10.1002/mds.26802  0.52
2016 Hsieh CH, Shaltouki A, Gonzalez AE, Bettencourt da Cruz A, Burbulla LF, St Lawrence E, Schüle B, Krainc D, Palmer TD, Wang X. Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson's Disease. Cell Stem Cell. PMID 27618216 DOI: 10.1016/j.stem.2016.08.002  0.36
2016 Burbulla LF, Beaumont KG, Mrksich M, Krainc D. Human Neuron Cultures: Micropatterning Facilitates the Long-Term Growth and Analysis of iPSC-Derived Individual Human Neurons and Neuronal Networks (Adv. Healthcare Mater. 15/2016). Advanced Healthcare Materials. 5: 1893. PMID 27511952 DOI: 10.1002/adhm.201670079  0.36
2016 Mazzulli JR, Zunke F, Tsunemi T, Toker NJ, Jeon S, Burbulla LF, Patnaik S, Sidransky E, Marugan JJ, Sue CM, Krainc D. Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 7693-706. PMID 27445146 DOI: 10.1523/JNEUROSCI.0628-16.2016  0.36
2016 Deng HX, Shi Y, Yang Y, Ahmeti KB, Miller N, Huang C, Cheng L, Zhai H, Deng S, Nuytemans K, Corbett NJ, Kim MJ, Deng H, Tang B, Yang Z, ... ... Krainc D, et al. Identification of TMEM230 mutations in familial Parkinson's disease. Nature Genetics. PMID 27270108 DOI: 10.1038/ng.3589  0.36
2016 Burbulla LF, Beaumont KG, Mrksich M, Krainc D. Micropatterning Facilitates the Long-Term Growth and Analysis of iPSC-Derived Individual Human Neurons and Neuronal Networks. Advanced Healthcare Materials. PMID 27108930 DOI: 10.1002/adhm.201500900  0.36
2016 Domingo A, Amar D, Grütz K, Lee LV, Rosales R, Brüggemann N, Jamora RD, Cutiongco-Dela Paz E, Rolfs A, Dressler D, Walter U, Krainc D, Lohmann K, Shamir R, Klein C, et al. Evidence of TAF1 dysfunction in peripheral models of X-linked dystonia-parkinsonism. Cellular and Molecular Life Sciences : Cmls. PMID 26879577 DOI: 10.1007/s00018-016-2159-4  0.4
2016 Mazzulli JR, Burbulla LF, Krainc D, Ischiropoulos H. Detection of Free and Protein-Bound ortho-Quinones by Near-Infrared Fluorescence. Analytical Chemistry. 88: 2399-405. PMID 26813311 DOI: 10.1021/acs.analchem.5b04420  0.36
2016 Domingo A, Amar D, Grütz K, Lee LV, Rosales R, Brüggemann N, Jamora RD, Cutiongco-Dela Paz E, Rolfs A, Dressler D, Walter U, Krainc D, Lohmann K, Shamir R, Klein C, et al. Evidence of TAF1 dysfunction in peripheral models of X-linked dystonia-parkinsonism Cellular and Molecular Life Sciences. 1-11. DOI: 10.1007/s00018-016-2159-4  0.4
2013 Klein C, Krainc D. Glucocerebrosidase mutations: tipping point toward Parkinson disease and dementia? Jama Neurology. 70: 686-8. PMID 23588619 DOI: 10.1001/jamaneurol.2013.87  0.4
2013 Rakovic A, Shurkewitsch K, Seibler P, Grünewald A, Zanon A, Hagenah J, Krainc D, Klein C. Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: study in human primary fibroblasts and induced pluripotent stem cell-derived neurons. The Journal of Biological Chemistry. 288: 2223-37. PMID 23212910 DOI: 10.1074/jbc.M112.391680  0.4
2012 Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... ... Krainc D, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490 DOI: 10.4161/auto.19496  0.36
2012 Cooper O, Seo H, Andrabi S, Guardia-Laguarta C, Graziotto J, Sundberg M, McLean JR, Carrillo-Reid L, Xie Z, Osborn T, Hargus G, Deleidi M, Lawson T, Bogetofte H, Perez-Torres E, ... ... Krainc D, et al. Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease. Science Translational Medicine. 4: 141ra90. PMID 22764206 DOI: 10.1126/scitranslmed.3003985  0.4
2012 Klein C, Krainc D. Movement disorders in 2011: Translating new research findings into clinical practice. Nature Reviews. Neurology. 8: 65-6. PMID 22187001 DOI: 10.1038/nrneurol.2011.212  0.4
2012 Palada V, Terzić J, Mazzulli J, Bwala G, Hagenah J, Peterlin B, Hung AY, Klein C, Krainc D. Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease. Neurobiology of Aging. 33: 836.e1-3. PMID 21794955 DOI: 10.1016/j.neurobiolaging.2011.06.015  0.4
2011 Seibler P, Graziotto J, Jeong H, Simunovic F, Klein C, Krainc D. Mitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 5970-6. PMID 21508222 DOI: 10.1523/JNEUROSCI.4441-10.2011  0.4
2011 Klein C, Krainc D, Schlossmacher MG, Lang AE. Translational research in neurology and neuroscience 2011: movement disorders. Archives of Neurology. 68: 709-16. PMID 21320985 DOI: 10.1001/archneurol.2011.11  0.4
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