Shyh-Dar Li, Ph.D. - Publications

Affiliations: 
2008 Pharmaceutical Sciences University of North Carolina, Chapel Hill, Chapel Hill, NC 

70 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Swetha KL, Maravajjala KS, Li SD, Singh MS, Roy A. Breaking the niche: multidimensional nanotherapeutics for tumor microenvironment modulation. Drug Delivery and Translational Research. PMID 35697894 DOI: 10.1007/s13346-022-01194-7  0.371
2022 Nguyen A, Rouhollahi E, Böttger R, Ong CY, Chao PH, Wu J, Chen Y, Li SD. Interplay between the linker and polymer molecular weight of a self-assembling prodrug on the pharmacokinetics and therapeutic efficacy. Biomaterials Science. PMID 35544350 DOI: 10.1039/d1bm01947c  0.306
2020 Nguyen A, Ando H, Böttger R, DurgaRao Viswanadham KK, Rouhollahi E, Ishida T, Li SD. Utilization of click chemistry to study the effect of poly(ethylene)glycol molecular weight on the self-assembly of PEGylated gambogic acid nanoparticles for the treatment of rheumatoid arthritis. Biomaterials Science. PMID 32700691 DOI: 10.1039/D0Bm00711K  0.386
2020 Böttger R, Pauli G, Chao PH, Al-Fayez N, Hohenwarter L, Li SD. Lipid-based nanoparticle technologies for liver targeting. Advanced Drug Delivery Reviews. PMID 32574575 DOI: 10.1016/J.Addr.2020.06.017  0.381
2019 Pauli G, Tang WL, Li SD. Development and Characterization of the Solvent-Assisted Active Loading Technology (SALT) for Liposomal Loading of Poorly Water-Soluble Compounds. Pharmaceutics. 11. PMID 31505795 DOI: 10.3390/Pharmaceutics11090465  0.321
2019 Zhang W, Böttger R, Qin Z, Kulkarni JA, Vogler J, Cullis PR, Li SD. Phospholipid-Free Small Unilamellar Vesicles for Drug Targeting to Cells in the Liver. Small (Weinheim An Der Bergstrasse, Germany). e1901782. PMID 31490617 DOI: 10.1002/Smll.201901782  0.39
2019 Hamano N, Böttger R, Lee SE, Yang Y, Kulkarni JA, Ip S, Cullis PR, Li SD. A robust microfluidic technology and a new lipid composition for fabrication of curcumin-loaded liposomes: Effect on the anticancer activity and safety of cisplatin. Molecular Pharmaceutics. PMID 31381352 DOI: 10.1021/Acs.Molpharmaceut.9B00583  0.424
2018 Mahjub R, Jatana S, Lee SE, Qin Z, Pauli G, Soleimani M, Madadi S, Li SD. Recent advances in applying nanotechnologies for cancer immunotherapy. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 30223043 DOI: 10.1016/J.Jconrel.2018.09.010  0.414
2018 Agrawal M, Saraf S, Saraf S, Antimisiaris SG, Hamano N, Li SD, Chougule M, Shoyele SA, Gupta U, Ajazuddin, Alexander A. Recent advancements in the field of nanotechnology for the delivery of anti-Alzheimer drug in the brain region. Expert Opinion On Drug Delivery. PMID 29733231 DOI: 10.1080/17425247.2018.1471058  0.336
2018 Tang WL, Tang WH, Li SD. Cancer theranostic applications of lipid-based nanoparticles. Drug Discovery Today. PMID 29660478 DOI: 10.1016/J.Drudis.2018.04.007  0.368
2018 Tang WL, Tang WH, Szeitz A, Kulkarni J, Cullis P, Li SD. Systemic study of solvent-assisted active loading of gambogic acid into liposomes and its formulation optimization for improved delivery. Biomaterials. 166: 13-26. PMID 29529479 DOI: 10.1016/J.Biomaterials.2018.03.004  0.397
2018 Li SD. A celebration of Professor Leaf Huang's contribution to the field of drug delivery and his lifetime achievement award. Journal of Drug Targeting. 1-3. PMID 29455560 DOI: 10.1080/1061186X.2018.1440924  0.312
2018 Ho L, Bokharaei M, Li SD. Current update of a thermosensitive liposomes composed of DPPC and Brij78. Journal of Drug Targeting. 1-41. PMID 29325469 DOI: 10.1080/1061186X.2017.1419361  0.426
2017 Chih-Chun C, Yang Y, Gao DY, Cheng HT, Hoang B, Chao PH, Chen LH, Bteich J, Chiang T, Liu JY, Li SD, Chen Y. Docetaxel-carboxymethylcellulose nanoparticles ameliorate CCl4-induced hepatic fibrosis in Mice. Journal of Drug Targeting. 1-27. PMID 29251522 DOI: 10.1080/1061186X.2017.1419358  0.507
2017 Hoang B, Ernsting MJ, Tang WS, Bteich J, Undzys E, Kiyota T, Li SD. Cabazitaxel-Conjugated Nanoparticles for Docetaxel-Resistant and Bone Metastatic Prostate Cancer. Cancer Letters. PMID 28965854 DOI: 10.1016/J.Canlet.2017.09.029  0.355
2017 Roy A, Zhao Y, Yang Y, Szeitz A, Klassen T, Li SD. Selective targeting and therapy of metastatic and multidrug resistant tumors using a long circulating podophyllotoxin nanoparticle. Biomaterials. 137: 11-22. PMID 28528299 DOI: 10.1016/J.Biomaterials.2017.05.019  0.459
2017 Tang WL, Tang WS, Chen WC, Diako C, Ross CF, Li SD. Development of a Rapidly Dissolvable Oral Pediatric Formulation for Mefloquine Using Liposomes. Molecular Pharmaceutics. PMID 28460165 DOI: 10.1021/Acs.Molpharmaceut.7B00077  0.347
2017 Yang Y, Roy A, Zhao Y, Undzys E, Li SD. Comparison of tumor penetration of podophyllotoxin-carboxymethylcellulose conjugates with various chemical compositions in tumor spheroid culture and in vivo solid tumor. Bioconjugate Chemistry. PMID 28437080 DOI: 10.1021/Acs.Bioconjchem.7B00165  0.45
2017 Hysi E, Wirtzfeld LA, May JP, Undzys E, Li SD, Kolios MC. Photoacoustic signal characterization of cancer treatment response: Correlation with changes in tumor oxygenation. Photoacoustics. 5: 25-35. PMID 28393017 DOI: 10.1016/J.Pacs.2017.03.003  0.336
2016 Yang Y, Bteich J, Li SD. Current Update of a Carboxymethylcellulose-PEG Conjugate Platform for Delivery of Insoluble Cytotoxic Agents to Tumors. The Aaps Journal. PMID 27873118 DOI: 10.1208/S12248-016-0014-Z  0.468
2016 May JP, Hysi E, Wirtzfeld LA, Undzys E, Li SD, Kolios MC. Photoacoustic Imaging of Cancer Treatment Response: Early Detection of Therapeutic Effect from Thermosensitive Liposomes. Plos One. 11: e0165345. PMID 27788199 DOI: 10.1371/Journal.Pone.0165345  0.371
2016 Hu B, Zhang K, Li S, Li H, Yan Z, Huang L, Wu J, Han X, Jiang W, Mulatibieke T, Zheng L, Wan R, Wang X, Hu G. HIC1 attenuates invasion and metastasis by inhibiting the IL-6/STAT3 signalling pathway in human pancreatic cancer. Cancer Letters. PMID 27085461 DOI: 10.1016/j.canlet.2016.04.013  0.368
2016 Roy A, Li SD. Modifying the tumor microenvironment using nanoparticle therapeutics. Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology. PMID 27038329 DOI: 10.1002/Wnan.1406  0.439
2016 Li S, Fang C, Zhang J, Liu B, Wei Z, Fan X, Sui Z, Tan Q. Catanionic lipid nanosystems improve pharmacokinetics and anti-lung cancer activity of curcumin. Nanomedicine : Nanotechnology, Biology, and Medicine. PMID 26995093 DOI: 10.1016/j.nano.2016.02.007  0.309
2016 Tang WL, Chen WC, Roy A, Undzys E, Li SD. A Simple and Improved Active Loading Method to Efficiently Encapsulate Staurosporine into Lipid-Based Nanoparticles for Enhanced Therapy of Multidrug Resistant Cancer. Pharmaceutical Research. PMID 26758590 DOI: 10.1007/S11095-015-1854-4  0.44
2016 Bteich J, Hoang B, Undzys E, Mohammed M, Su AL, Ou K, Emerson D, Sokoll K, Li S, Trikha M, Lowman H, Ernsting MJ. Abstract 1342: A production-scalable cabazitaxel cellulose nanoparticle exhibits significant efficacy in a bone model of docetaxel-resistant prostate cancer Cancer Research. 76: 1342-1342. DOI: 10.1158/1538-7445.Am2016-1342  0.324
2016 Hysi E, May JP, Wirtzfeld L, Undzys E, Li S, Kolios MC. Monitoring cancer treatment response using photoacoustic and ultrasound spectral analysis in combination with oxygenation measurements (Conference Presentation) Proceedings of Spie. 9708: 970824. DOI: 10.1117/12.2213596  0.314
2015 May J, Undzys E, Roy A, Li SD. Synthesis of a gemcitabine pro-drug for remote loading into liposomes and improved therapeutic effect. Bioconjugate Chemistry. PMID 26673036 DOI: 10.1021/Acs.Bioconjchem.5B00619  0.375
2015 Li S, Chen SJ, Chen Y. An ab initio investigation on the ground electronic state of chlorine monoxide and its singly charged cation and anion. Spectrochimica Acta. Part a, Molecular and Biomolecular Spectroscopy. 152: 453-460. PMID 26247329 DOI: 10.1016/j.saa.2015.07.100  0.448
2015 Zhao Y, May JP, Chen IW, Undzys E, Li SD. A Study of Liposomal Formulations to Improve the Delivery of Aquated Cisplatin to a Multidrug Resistant Tumor. Pharmaceutical Research. 32: 3261-8. PMID 25964047 DOI: 10.1007/S11095-015-1702-6  0.405
2015 Hoang B, Ernsting MJ, Roy A, Murakami M, Undzys E, Li SD. Docetaxel-carboxymethylcellulose nanoparticles target cells via a SPARC and albumin dependent mechanism. Biomaterials. 59: 66-76. PMID 25956852 DOI: 10.1016/J.Biomaterials.2015.04.032  0.431
2015 Roy A, Ernsting MJ, Undzys E, Li SD. A highly tumor-targeted nanoparticle of podophyllotoxin penetrated tumor core and regressed multidrug resistant tumors. Biomaterials. 52: 335-46. PMID 25818440 DOI: 10.1016/J.Biomaterials.2015.02.041  0.449
2015 Ernsting MJ, Hoang B, Lohse I, Undzys E, Cao P, Do T, Gill B, Pintilie M, Hedley D, Li SD. Targeting of metastasis-promoting tumor-associated fibroblasts and modulation of pancreatic tumor-associated stroma with a carboxymethylcellulose-docetaxel nanoparticle. Journal of Controlled Release : Official Journal of the Controlled Release Society. 206: 122-30. PMID 25804872 DOI: 10.1016/J.Jconrel.2015.03.023  0.437
2015 Hysi E, May JP, Writzfeld L, Undyzs E, Li SD, Kolios MC. Probing the in vivo changes in oxygen saturation with photoacoustic imaging as a non-invasive means of assessing treatment progression Progress in Biomedical Optics and Imaging - Proceedings of Spie. 9323. DOI: 10.1117/12.2080372  0.382
2014 Hoang B, Ernsting MJ, Murakami M, Undzys E, Li SD. Docetaxel-carboxymethylcellulose nanoparticles display enhanced anti-tumor activity in murine models of castration-resistant prostate cancer. International Journal of Pharmaceutics. 471: 224-33. PMID 24853460 DOI: 10.1016/J.Ijpharm.2014.05.021  0.412
2014 Roy A, Bhattacharyya M, Ernsting MJ, May JP, Li SD. Recent progress in the development of polysaccharide conjugates of docetaxel and paclitaxel. Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology. 6: 349-68. PMID 24652678 DOI: 10.1002/Wnan.1264  0.339
2014 Roy A, Murakami M, Ernsting MJ, Hoang B, Undzys E, Li SD. Carboxymethylcellulose-based and docetaxel-loaded nanoparticles circumvent P-glycoprotein-mediated multidrug resistance. Molecular Pharmaceutics. 11: 2592-9. PMID 24564177 DOI: 10.1021/Mp400643P  0.413
2014 May JP, Hysi E, Wirtzfeld L, Undzys E, Kolios MC, Li S. Abstract LB-165: Early detection of the therapeutic effect in tumors treated with a thermosensitive liposome (TSL) using noninvasive ultrasound and photoacoustic imaging Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Lb-165  0.423
2014 Ernsting M, Murakami M, Undzys E, Li S. Abstract 4486: Stromal depletion by a docetaxel nanoparticle for enhanced therapy of breast and pancreatic cancer Cancer Research. 74: 4486-4486. DOI: 10.1158/1538-7445.Am2014-4486  0.447
2013 May JP, Ernsting MJ, Undzys E, Li SD. Thermosensitive liposomes for the delivery of gemcitabine and oxaliplatin to tumors. Molecular Pharmaceutics. 10: 4499-508. PMID 24152292 DOI: 10.1021/Mp400321E  0.424
2013 Ernsting MJ, Murakami M, Roy A, Li SD. Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles. Journal of Controlled Release : Official Journal of the Controlled Release Society. 172: 782-94. PMID 24075927 DOI: 10.1016/J.Jconrel.2013.09.013  0.462
2013 Murakami M, Ernsting MJ, Undzys E, Holwell N, Foltz WD, Li SD. Docetaxel conjugate nanoparticles that target α-smooth muscle actin-expressing stromal cells suppress breast cancer metastasis. Cancer Research. 73: 4862-71. PMID 23907638 DOI: 10.1158/0008-5472.Can-13-0062  0.447
2013 May JP, Li SD. Hyperthermia-induced drug targeting. Expert Opinion On Drug Delivery. 10: 511-27. PMID 23289519 DOI: 10.1517/17425247.2013.758631  0.401
2013 Chen WC, May JP, Li SD. Immune responses of therapeutic lipid nanoparticles Nanotechnology Reviews. 2: 201-213. DOI: 10.1515/Ntrev-2012-0040  0.353
2012 Ernsting MJ, Murakami M, Undzys E, Aman A, Press B, Li SD. A docetaxel-carboxymethylcellulose nanoparticle outperforms the approved taxane nanoformulation, Abraxane, in mouse tumor models with significant control of metastases. Journal of Controlled Release : Official Journal of the Controlled Release Society. 162: 575-81. PMID 22967490 DOI: 10.1016/J.Jconrel.2012.07.043  0.466
2012 Tagami T, May JP, Ernsting MJ, Li SD. A thermosensitive liposome prepared with a Cu²⁺ gradient demonstrates improved pharmacokinetics, drug delivery and antitumor efficacy. Journal of Controlled Release : Official Journal of the Controlled Release Society. 161: 142-9. PMID 22504351 DOI: 10.1016/J.Jconrel.2012.03.023  0.387
2012 Ernsting MJ, Foltz WD, Undzys E, Tagami T, Li SD. Tumor-targeted drug delivery using MR-contrasted docetaxel - carboxymethylcellulose nanoparticles. Biomaterials. 33: 3931-41. PMID 22369962 DOI: 10.1016/J.Biomaterials.2012.02.019  0.442
2012 Ernsting MJ, Tang WL, MacCallum NW, Li SD. Preclinical pharmacokinetic, biodistribution, and anti-cancer efficacy studies of a docetaxel-carboxymethylcellulose nanoparticle in mouse models. Biomaterials. 33: 1445-54. PMID 22079003 DOI: 10.1016/J.Biomaterials.2011.10.061  0.423
2012 Chen WC, Zhang AX, Li SD. Limitations and niches of the active targeting approach for nanoparticle drug delivery European Journal of Nanomedicine. 4: 89-93. DOI: 10.1515/Ejnm-2012-0010  0.457
2011 Ernsting MJ, Tang WL, MacCallum N, Li SD. Synthetic modification of carboxymethylcellulose and use thereof to prepare a nanoparticle forming conjugate of docetaxel for enhanced cytotoxicity against cancer cells. Bioconjugate Chemistry. 22: 2474-86. PMID 22014112 DOI: 10.1021/Bc200284B  0.439
2011 Tagami T, Foltz WD, Ernsting MJ, Lee CM, Tannock IF, May JP, Li SD. MRI monitoring of intratumoral drug delivery and prediction of the therapeutic effect with a multifunctional thermosensitive liposome. Biomaterials. 32: 6570-8. PMID 21641639 DOI: 10.1016/J.Biomaterials.2011.05.029  0.401
2011 Tagami T, Ernsting MJ, Li SD. Optimization of a novel and improved thermosensitive liposome formulated with DPPC and a Brij surfactant using a robust in vitro system. Journal of Controlled Release : Official Journal of the Controlled Release Society. 154: 290-7. PMID 21640149 DOI: 10.1016/J.Jconrel.2011.05.020  0.348
2011 Tagami T, Ernsting MJ, Li SD. Efficient tumor regression by a single and low dose treatment with a novel and enhanced formulation of thermosensitive liposomal doxorubicin. Journal of Controlled Release : Official Journal of the Controlled Release Society. 152: 303-9. PMID 21338635 DOI: 10.1016/J.Jconrel.2011.02.009  0.454
2010 Bauman JA, Li SD, Yang A, Huang L, Kole R. Anti-tumor activity of splice-switching oligonucleotides. Nucleic Acids Research. 38: 8348-56. PMID 20719743 DOI: 10.1093/Nar/Gkq731  0.444
2010 Li SD, Huang L. Stealth nanoparticles: high density but sheddable PEG is a key for tumor targeting. Journal of Controlled Release : Official Journal of the Controlled Release Society. 145: 178-81. PMID 20338200 DOI: 10.1016/j.jconrel.2010.03.016  0.488
2010 Li SD, Howell SB. CD44-targeted microparticles for delivery of cisplatin to peritoneal metastases. Molecular Pharmaceutics. 7: 280-90. PMID 19994852 DOI: 10.1021/Mp900242F  0.345
2009 Li SD, Huang L. Nanoparticles evading the reticuloendothelial system: role of the supported bilayer. Biochimica Et Biophysica Acta. 1788: 2259-66. PMID 19595666 DOI: 10.1016/j.bbamem.2009.06.022  0.454
2008 Li SD, Huang L. Targeted delivery of siRNA by nonviral vectors: lessons learned from recent advances. Current Opinion in Investigational Drugs (London, England : 2000). 9: 1317-23. PMID 19037838  0.476
2008 Chono S, Li SD, Conwell CC, Huang L. An efficient and low immunostimulatory nanoparticle formulation for systemic siRNA delivery to the tumor. Journal of Controlled Release : Official Journal of the Controlled Release Society. 131: 64-9. PMID 18674578 DOI: 10.1016/j.jconrel.2008.07.006  0.51
2008 Li SD, Huang L. Pharmacokinetics and biodistribution of nanoparticles. Molecular Pharmaceutics. 5: 496-504. PMID 18611037 DOI: 10.1021/Mp800049W  0.476
2008 Li SD, Chono S, Huang L. Efficient oncogene silencing and metastasis inhibition via systemic delivery of siRNA. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 942-6. PMID 18388916 DOI: 10.1038/mt.2008.51  0.475
2008 Li SD, Chono S, Huang L. Efficient gene silencing in metastatic tumor by siRNA formulated in surface-modified nanoparticles. Journal of Controlled Release : Official Journal of the Controlled Release Society. 126: 77-84. PMID 18083264 DOI: 10.1016/j.jconrel.2007.11.002  0.483
2008 Li SD, Chen YC, Hackett MJ, Huang L. Tumor-targeted delivery of siRNA by self-assembled nanoparticles. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 163-9. PMID 17923843 DOI: 10.1038/Sj.Mt.6300323  0.638
2007 Li SD, Huang L. Non-viral is superior to viral gene delivery. Journal of Controlled Release : Official Journal of the Controlled Release Society. 123: 181-3. PMID 17935817 DOI: 10.1016/j.jconrel.2007.09.004  0.36
2006 Li SD, Huang L. Surface-modified LPD nanoparticles for tumor targeting. Annals of the New York Academy of Sciences. 1082: 1-8. PMID 17145918 DOI: 10.1196/annals.1348.001  0.51
2006 Li SD, Huang L. Targeted delivery of antisense oligodeoxynucleotide and small interference RNA into lung cancer cells. Molecular Pharmaceutics. 3: 579-88. PMID 17009857 DOI: 10.1021/mp060039w  0.521
2006 Li SD, Huang L. Gene therapy progress and prospects: non-viral gene therapy by systemic delivery. Gene Therapy. 13: 1313-9. PMID 16953249 DOI: 10.1038/sj.gt.3302838  0.428
2006 Li S, Huang L. 715. Targeted Delivery of Antisense Oligonucleotide and siRNA into Lung Cancer Cells Molecular Therapy. 13: S276. DOI: 10.1016/J.Ymthe.2006.08.794  0.478
1999 Whitmore M, Li S, Huang L. LPD lipopolyplex initiates a potent cytokine response and inhibits tumor growth. Gene Therapy. 6: 1867-1875. PMID 10602382 DOI: 10.1038/Sj.Gt.3301026  0.502
1997 Li S, Huang L. In vivo gene transfer via intravenous administration of cationic lipid–protamine–DNA (LPD) complexes Gene Therapy. 4: 891-900. PMID 9349425 DOI: 10.1038/Sj.Gt.3300482  0.452
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