Ann-Charlotte Granholm - Publications

Affiliations: 
MUSC, Santa Clara, Villa Clara, Cuba 
Area:
aging, dopamine, neurodegeneration

141 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Aldecoa I, Barroeta I, Carroll SL, Fortea J, Gilmore A, Ginsberg SD, Guzman SJ, Hamlett ED, Head E, Perez SE, Potter H, Molina-Porcel L, Raha-Chowdhury R, Wisniewski T, Yong WH, ... ... Granholm AC, et al. Down Syndrome Biobank Consortium: A perspective. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 38270275 DOI: 10.1002/alz.13692  0.539
2023 Colvett I, Gilmore A, Guzman S, Ledreux A, Quintero JE, Ginjupally DR, Gurwell JA, Slevin JT, Guduru Z, Gerhardt GA, van Horne CG, Granholm AC. Recipient Reaction and Composition of Autologous Sural Nerve Tissue Grafts into the Human Brain. Journal of Clinical Medicine. 12. PMID 37834764 DOI: 10.3390/jcm12196121  0.477
2021 Ledreux A, Thomas S, Hamlett ED, Trautman C, Gilmore A, Rickman Hager E, Paredes DA, Margittai M, Fortea J, Granholm AC. Small Neuron-Derived Extracellular Vesicles from Individuals with Down Syndrome Propagate Tau Pathology in the Wildtype Mouse Brain. Journal of Clinical Medicine. 10. PMID 34501378 DOI: 10.3390/jcm10173931  0.301
2020 Hamlett ED, Hjorth E, Ledreux A, Gilmore A, Schultzberg M, Granholm AC. RvE1 treatment prevents memory loss and neuroinflammation in the Ts65Dn mouse model of Down syndrome. Glia. PMID 31944407 DOI: 10.1002/glia.23779  0.301
2020 Emre C, Hjorth E, Bharani K, Carroll S, Granholm AC, Schultzberg M. Receptors for pro-resolving mediators are increased in Alzheimer's disease brain. Brain Pathology (Zurich, Switzerland). PMID 31912564 DOI: 10.1111/Bpa.12812  0.79
2019 Bharani KL, Ledreux A, Gilmore A, Carroll SL, Granholm AC. Serum pro-BDNF levels correlate with phospho-tau staining in Alzheimer's disease. Neurobiology of Aging. PMID 31882186 DOI: 10.1016/J.Neurobiolaging.2019.11.010  0.792
2019 Haytural H, Mermelekas G, Emre C, Nigam SM, Carroll SL, Winblad B, Bogdanovic N, Barthet G, Granholm AC, Orre LM, Tjernberg LO, Frykman S. The proteome of the dentate terminal zone of the perforant path indicates presynaptic impairment in Alzheimer disease. Molecular & Cellular Proteomics : McP. PMID 31699905 DOI: 10.1074/Mcp.Ra119.001737  0.515
2019 Hamlett ED, Ledreux A, Gilmore A, Vazey EM, Aston-Jones G, Boger HA, Paredes D, Granholm AE. Inhibitory designer receptors aggravate memory loss in a mouse model of down syndrome. Neurobiology of Disease. 134: 104616. PMID 31678403 DOI: 10.1016/J.Nbd.2019.104616  0.814
2017 Bharani KL, Derex R, Granholm AC, Ledreux A. A noradrenergic lesion aggravates the effects of systemic inflammation on the hippocampus of aged rats. Plos One. 12: e0189821. PMID 29261743 DOI: 10.1371/Journal.Pone.0189821  0.792
2017 Buhusi M, Etheredge C, Granholm AC, Buhusi CV. Increased Hippocampal ProBDNF Contributes to Memory Impairments in Aged Mice. Frontiers in Aging Neuroscience. 9: 284. PMID 28912711 DOI: 10.3389/Fnagi.2017.00284  0.431
2016 Hamlett ED, Goetzl EJ, Ledreux A, Vasilevko V, Boger HA, LaRosa A, Clark D, Carroll SL, Carmona Iragui M, Fortea J, Mufson EJ, Sabbagh M, Mohammed AH, Hartley D, Doran E, ... ... Granholm AC, et al. Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 27755974 DOI: 10.1016/j.jalz.2016.08.012  0.781
2016 Ledreux A, Wang X, Schultzberg M, Granholm AC, Freeman LR. Detrimental effects of a high fat/high cholesterol diet on memory and hippocampal markers in aged rats. Behavioural Brain Research. PMID 27343935 DOI: 10.1016/j.bbr.2016.06.012  0.664
2016 Rosenberger DS, Falangola MF, Ledreux A, Nie X, Suhre WM, Boger HA, Granholm AC. MEMORY AND HIPPOCAMPAL ARCHITECTURE FOLLOWING SHORT-TERM MIDAZOLAM IN WESTERN DIET-TREATED RATS. Neuroscience Letters. PMID 27080429 DOI: 10.1016/j.neulet.2016.04.021  0.8
2015 Spratt EG, Granholm AC, Carpenter LA, Boger HA, Papa CE, Logan S, Chaudhary H, Boatwright SW, Brady KT. Pilot Study and Review: Physiological Differences in BDNF, a Potential Biomarker in Males and Females with Autistic Disorder. International Neuropsychiatric Disease Journal. 3: 19-26. PMID 26866045 DOI: 10.9734/INDJ/2015/12118  0.79
2015 Zhu M, Wang X, Hjorth E, Colas RA, Schroeder L, Granholm AC, Serhan CN, Schultzberg M. Pro-Resolving Lipid Mediators Improve Neuronal Survival and Increase Aβ42 Phagocytosis. Molecular Neurobiology. PMID 26650044 DOI: 10.1007/S12035-015-9544-0  0.336
2015 Ledreux A, Boger HA, Hinson VK, Cantwell K, Granholm AC. BDNF levels are increased by aminoindan and rasagiline in a double lesion model of Parkinson׳s disease. Brain Research. PMID 26607251 DOI: 10.1016/j.brainres.2015.11.028  0.798
2015 Hamlett E, Boger HA, Ledreux A, Kelley CM, Mufson EJ, Falangola MF, Guilfoyle DN, Nixon RA, Patterson D, Duval N, Granholm AE. Cognitive Impairment, Neuroimaging, and Alzheimer Neuropathology in Mouse Models of Down Syndrome. Current Alzheimer Research. PMID 26391050 DOI: 10.2174/1567205012666150921095505  0.794
2015 Fortress AM, Hamlett ED, Vazey EM, Aston-Jones G, Cass WA, Boger HA, Granholm AC. Designer receptors enhance memory in a mouse model of Down syndrome. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 1343-53. PMID 25632113 DOI: 10.1523/Jneurosci.2658-14.2015  0.813
2015 Nie X, Hamlett ED, Granholm AC, Hui ES, Helpern JA, Jensen JH, Boger HA, Collins HR, Falangola MF. Evidence of altered age-related brain cytoarchitecture in mouse models of down syndrome: a diffusional kurtosis imaging study. Magnetic Resonance Imaging. 33: 437-47. PMID 25527393 DOI: 10.1016/J.Mri.2014.12.008  0.812
2014 Cunningham MA, Wirth JR, Freeman LR, Boger HA, Granholm AC, Gilkeson GS. Estrogen receptor alpha deficiency protects against development of cognitive impairment in murine lupus. Journal of Neuroinflammation. 11: 171. PMID 25510908 DOI: 10.1186/S12974-014-0171-X  0.804
2014 Iulita MF, Do Carmo S, Ower AK, Fortress AM, Aguilar LF, Hanna M, Wisniewski T, Granholm AC, Buhusi M, Busciglio J, Cuello AC. Nerve growth factor metabolic dysfunction in Down's syndrome brains. Brain : a Journal of Neurology. 137: 860-72. PMID 24519975 DOI: 10.1093/Brain/Awt372  0.767
2014 Freeman LR, Haley-Zitlin V, Rosenberger DS, Granholm AC. Damaging effects of a high-fat diet to the brain and cognition: a review of proposed mechanisms. Nutritional Neuroscience. 17: 241-51. PMID 24192577 DOI: 10.1179/1476830513Y.0000000092  0.57
2014 Karakostas T, Hsiang S, Boger H, Middaugh L, Granholm AC. Three-dimensional rodent motion analysis and neurodegenerative disorders. Journal of Neuroscience Methods. 231: 31-7. PMID 24129039 DOI: 10.1016/J.Jneumeth.2013.09.009  0.768
2013 Littrell OM, Granholm AC, Gerhardt GA, Boger HA. Glial cell-line derived neurotrophic factor (GDNF) replacement attenuates motor impairments and nigrostriatal dopamine deficits in 12-month-old mice with a partial deletion of GDNF. Pharmacology, Biochemistry, and Behavior. 104: 10-9. PMID 23290934 DOI: 10.1016/J.Pbb.2012.12.022  0.822
2012 Zhang Y, Granholm AC, Huh K, Shan L, Diaz-Ruiz O, Malik N, Olson L, Hoffer BJ, Lupica CR, Hoffman AF, Bäckman CM. PTEN deletion enhances survival, neurite outgrowth and function of dopamine neuron grafts to MitoPark mice. Brain : a Journal of Neurology. 135: 2736-49. PMID 22961549 DOI: 10.1093/Brain/Aws196  0.81
2012 Lockrow JP, Fortress AM, Granholm AC. Age-related neurodegeneration and memory loss in down syndrome. Current Gerontology and Geriatrics Research. 2012: 463909. PMID 22545043 DOI: 10.1155/2012/463909  0.801
2012 Freeman LR, Granholm AC. Vascular changes in rat hippocampus following a high saturated fat and cholesterol diet. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 32: 643-53. PMID 22108721 DOI: 10.1038/jcbfm.2011.168  0.616
2012 Littrell OM, Pomerleau F, Huettl P, Surgener S, McGinty JF, Middaugh LD, Granholm AC, Gerhardt GA, Boger HA. Enhanced dopamine transporter activity in middle-aged Gdnf heterozygous mice. Neurobiology of Aging. 33: 427.e1-14. PMID 21144620 DOI: 10.1016/J.Neurobiolaging.2010.10.013  0.809
2012 Alanis M, Umphlet C, Boger H, Granholm A. 426: Adolescent cognitive and anxiety behavior in offspring following in utero exposure to increased trans unsaturated fatty acids through maternal diet American Journal of Obstetrics and Gynecology. 206: S197. DOI: 10.1016/J.AJOG.2011.10.444  0.759
2011 Fortress AM, Buhusi M, Helke KL, Granholm AC. Cholinergic Degeneration and Alterations in the TrkA and p75NTR Balance as a Result of Pro-NGF Injection into Aged Rats. Journal of Aging Research. 2011: 460543. PMID 21785728 DOI: 10.4061/2011/460543  0.758
2011 Freeman LR, Haley-Zitlin V, Stevens C, Granholm AC. Diet-induced effects on neuronal and glial elements in the middle-aged rat hippocampus. Nutritional Neuroscience. 14: 32-44. PMID 21535919 DOI: 10.1179/174313211X12966635733358  0.607
2011 Freeman LR, Small BJ, Bickford PC, Umphlet C, Granholm AC. A high-fat/high-cholesterol diet inhibits growth of fetal hippocampal transplants via increased inflammation. Cell Transplantation. 20: 1499-514. PMID 21396159 DOI: 10.3727/096368910X557281  0.7
2011 Lockrow J, Boger H, Gerhardt G, Aston-Jones G, Bachman D, Granholm AC. A noradrenergic lesion exacerbates neurodegeneration in a Down syndrome mouse model. Journal of Alzheimer's Disease : Jad. 23: 471-89. PMID 21098982 DOI: 10.3233/JAD-2010-101218  0.818
2011 Granholm AC, Zaman V, Godbee J, Smith M, Ramadan R, Umphlet C, Randall P, Bhat NR, Rohrer B, Middaugh LD, Boger HA. Prenatal LPS increases inflammation in the substantia nigra of Gdnf heterozygous mice. Brain Pathology (Zurich, Switzerland). 21: 330-48. PMID 20969653 DOI: 10.1111/J.1750-3639.2010.00457.X  0.821
2011 Boger HA, Mannangatti P, Samuvel DJ, Saylor AJ, Bender TS, McGinty JF, Fortress AM, Zaman V, Huang P, Middaugh LD, Randall PK, Jayanthi LD, Rohrer B, Helke KL, Granholm AC, et al. Effects of brain-derived neurotrophic factor on dopaminergic function and motor behavior during aging. Genes, Brain, and Behavior. 10: 186-98. PMID 20860702 DOI: 10.1111/J.1601-183X.2010.00654.X  0.814
2011 Lockrow J, Boger H, Bimonte-Nelson H, Granholm AC. Effects of long-term memantine on memory and neuropathology in Ts65Dn mice, a model for Down syndrome. Behavioural Brain Research. 221: 610-22. PMID 20363261 DOI: 10.1016/j.bbr.2010.03.036  0.806
2010 Granholm AC. Why do we need to use animal models to study cognition and aging? Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 1621-2. PMID 20551899 DOI: 10.1038/npp.2010.45  0.348
2010 Willis LM, Freeman L, Bickford PC, Quintero EM, Umphlet CD, Moore AB, Goetzl L, Granholm AC. Blueberry supplementation attenuates microglial activation in hippocampal intraocular grafts to aged hosts. Glia. 58: 679-90. PMID 20014277 DOI: 10.1002/glia.20954  0.799
2010 Boger HA, Granholm AC, McGinty JF, Middaugh LD. A dual-hit animal model for age-related parkinsonism. Progress in Neurobiology. 90: 217-29. PMID 19853012 DOI: 10.1016/J.Pneurobio.2009.10.013  0.819
2010 Granholm AE, Freeman L. P4-036: Long-term Treatment With a High-fat Diet Causes Memory Loss and Breached Blood-brain Barrier in Aged Rats. Alzheimer's & Dementia. 6: e31-e31. DOI: 10.1016/j.jalz.2010.08.096  0.609
2009 Lockrow J, Prakasam A, Huang P, Bimonte-Nelson H, Sambamurti K, Granholm AC. Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model. Experimental Neurology. 216: 278-89. PMID 19135442 DOI: 10.1016/J.Expneurol.2008.11.021  0.799
2009 Boger HA, Middaugh LD, Granholm AC, McGinty JF. Minocycline restores striatal tyrosine hydroxylase in GDNF heterozygous mice but not in methamphetamine-treated mice. Neurobiology of Disease. 33: 459-66. PMID 19110059 DOI: 10.1016/J.Nbd.2008.11.013  0.806
2008 Granholm AC, Boger H, Emborg ME. Mood, memory and movement: an age-related neurodegenerative complex? Current Aging Science. 1: 133-9. PMID 20021382 DOI: 10.2174/1874609810801020133  0.792
2008 Zaman V, Boger HA, Granholm AC, Rohrer B, Moore A, Buhusi M, Gerhardt GA, Hoffer BJ, Middaugh LD. The nigrostriatal dopamine system of aging GFRalpha-1 heterozygous mice: neurochemistry, morphology and behavior. The European Journal of Neuroscience. 28: 1557-68. PMID 18973577 DOI: 10.1111/J.1460-9568.2008.06456.X  0.816
2008 Boger HA, Middaugh LD, Zaman V, Hoffer B, Granholm AC. Differential effects of the dopamine neurotoxin MPTP in animals with a partial deletion of the GDNF receptor, GFR alpha1, gene. Brain Research. 1241: 18-28. PMID 18822276 DOI: 10.1016/J.Brainres.2008.09.011  0.806
2008 Granholm AC, Bimonte-Nelson HA, Moore AB, Nelson ME, Freeman LR, Sambamurti K. Effects of a saturated fat and high cholesterol diet on memory and hippocampal morphology in the middle-aged rat. Journal of Alzheimer's Disease : Jad. 14: 133-45. PMID 18560126 DOI: 10.3233/Jad-2008-14202  0.738
2008 Willis LM, Small BJ, Bickford PC, Umphlet CD, Moore AB, Granholm AC. Dietary blueberry supplementation affects growth but not vascularization of neural transplants. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 28: 1150-64. PMID 18285804 DOI: 10.1038/jcbfm.2008.3  0.691
2008 Bimonte-Nelson HA, Granholm AC, Nelson ME, Moore AB. Patterns of neurotrophin protein levels in male and female Fischer 344 rats from adulthood to senescence: how young is "young" and how old is "old"? Experimental Aging Research. 34: 13-26. PMID 18189165 DOI: 10.1080/03610730701761908  0.61
2007 Boger HA, Middaugh LD, Patrick KS, Ramamoorthy S, Denehy ED, Zhu H, Pacchioni AM, Granholm AC, McGinty JF. Long-term consequences of methamphetamine exposure in young adults are exacerbated in glial cell line-derived neurotrophic factor heterozygous mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 8816-25. PMID 17699663 DOI: 10.1523/Jneurosci.1067-07.2007  0.816
2007 French KL, Bimonte-Nelson HA, Granholm AC. Galantamine effects on memory, spatial cue utilization, and neurotrophic factors in aged female rats. Cell Transplantation. 16: 197-205. PMID 17503733 DOI: 10.3727/000000007783464759  0.615
2007 Paredes D, Granholm AC, Bickford PC. Effects of NGF and BDNF on baseline glutamate and dopamine release in the hippocampal formation of the adult rat. Brain Research. 1141: 56-64. PMID 17292337 DOI: 10.1016/j.brainres.2007.01.018  0.54
2007 af Bjerkén S, Boger HA, Nelson M, Hoffer BJ, Granholm AC, Strömberg I. Effects of glial cell line-derived neurotrophic factor deletion on ventral mesencephalic organotypic tissue cultures. Brain Research. 1133: 10-9. PMID 17184739 DOI: 10.1016/j.brainres.2006.11.052  0.795
2007 Williams B, Granholm AC, Sambamurti K. Age-dependent loss of NGF signaling in the rat basal forebrain is due to disrupted MAPK activation. Neuroscience Letters. 413: 110-4. PMID 17182181 DOI: 10.1016/J.Neulet.2006.11.040  0.609
2006 Williams BJ, Eriksdotter-Jonhagen M, Granholm AC. Nerve growth factor in treatment and pathogenesis of Alzheimer's disease. Progress in Neurobiology. 80: 114-28. PMID 17084014 DOI: 10.1016/j.pneurobio.2006.09.001  0.56
2006 Boger HA, Middaugh LD, Huang P, Zaman V, Smith AC, Hoffer BJ, Tomac AC, Granholm AC. A partial GDNF depletion leads to earlier age-related deterioration of motor function and tyrosine hydroxylase expression in the substantia nigra. Experimental Neurology. 202: 336-47. PMID 16889771 DOI: 10.1016/J.Expneurol.2006.06.006  0.818
2006 Bimonte-Nelson HA, Francis KR, Umphlet CD, Granholm AC. Progesterone reverses the spatial memory enhancements initiated by tonic and cyclic oestrogen therapy in middle-aged ovariectomized female rats. The European Journal of Neuroscience. 24: 229-42. PMID 16882019 DOI: 10.1111/j.1460-9568.2006.04867.x  0.632
2006 Quintero EM, Willis L, Singleton R, Harris N, Huang P, Bhat N, Granholm AC. Behavioral and morphological effects of minocycline in the 6-hydroxydopamine rat model of Parkinson's disease. Brain Research. 1093: 198-207. PMID 16712819 DOI: 10.1016/j.brainres.2006.03.104  0.477
2006 French KL, Granholm AC, Moore AB, Nelson ME, Bimonte-Nelson HA. Chronic nicotine improves working and reference memory performance and reduces hippocampal NGF in aged female rats. Behavioural Brain Research. 169: 256-62. PMID 16488025 DOI: 10.1016/j.bbr.2006.01.008  0.605
2006 Griffin WC, Boger HA, Granholm AC, Middaugh LD. Partial deletion of glial cell line-derived neurotrophic factor (GDNF) in mice: Effects on sucrose reward and striatal GDNF concentrations. Brain Research. 1068: 257-60. PMID 16364262 DOI: 10.1016/J.Brainres.2005.10.080  0.793
2005 Granholm AC, Bachman D, Mintzer J, Sambamurti K. Commentary: "Ceramide and cholesterol: possible connections between normal aging of the brain and Alzheimer's disease. Just hypotheses or molecular pathways to be identified?" by Claudio Costantini, Rekha M.K. Kolasani, Luigi Puglielli. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 1: 53-4. PMID 19595818 DOI: 10.1016/J.Jalz.2005.06.010  0.307
2005 Williams B, Nelson M, Granholm AC, Coultrap S, Browning M, Curtis M. Altered NGF response but not release in the aged septo-hippocampal cholinergic system. Experimental Neurology. 196: 30-40. PMID 16137678 DOI: 10.1016/J.Expneurol.2005.07.001  0.694
2005 Willis L, Bickford P, Zaman V, Moore A, Granholm AC. Blueberry extract enhances survival of intraocular hippocampal transplants. Cell Transplantation. 14: 213-23. PMID 15929556 DOI: 10.3727/000000005783983142  0.708
2005 Willis L, Quintero EM, Nelson M, Granholm ACh. Regulation of trophic factor expression by innervating target regions in intraocular double transplants. Cell Transplantation. 14: 21-9. PMID 15789659  0.543
2004 Bimonte-Nelson HA, Nelson ME, Granholm AC. Progesterone counteracts estrogen-induced increases in neurotrophins in the aged female rat brain. Neuroreport. 15: 2659-63. PMID 15570173 DOI: 10.1097/00001756-200412030-00021  0.62
2004 Hunter CL, Bachman D, Granholm AC. Minocycline prevents cholinergic loss in a mouse model of Down's syndrome. Annals of Neurology. 56: 675-88. PMID 15468085 DOI: 10.1002/ana.20250  0.579
2004 Bimonte-Nelson HA, Singleton RS, Williams BJ, Granholm AC. Ovarian hormones and cognition in the aged female rat: II. progesterone supplementation reverses the cognitive enhancing effects of ovariectomy. Behavioral Neuroscience. 118: 707-14. PMID 15301598 DOI: 10.1037/0735-7044.118.4.707  0.687
2004 Hunter CL, Quintero EM, Gilstrap L, Bhat NR, Granholm AC. Minocycline protects basal forebrain cholinergic neurons from mu p75-saporin immunotoxic lesioning. The European Journal of Neuroscience. 19: 3305-16. PMID 15217386 DOI: 10.1111/j.0953-816X.2004.03439.x  0.559
2004 Hunter CL, Bimonte-Nelson HA, Nelson M, Eckman CB, Granholm AC. Behavioral and neurobiological markers of Alzheimer's disease in Ts65Dn mice: effects of estrogen. Neurobiology of Aging. 25: 873-84. PMID 15212841 DOI: 10.1016/j.neurobiolaging.2003.10.010  0.7
2004 Quintero EM, Willis LM, Zaman V, Lee J, Boger HA, Tomac A, Hoffer BJ, Strömberg I, Granholm AC. Glial cell line-derived neurotrophic factor is essential for neuronal survival in the locus coeruleus-hippocampal noradrenergic pathway. Neuroscience. 124: 137-46. PMID 14960346 DOI: 10.1016/j.neuroscience.2003.11.001  0.817
2003 Granholm AC, Sanders L, Seo H, Lin L, Ford K, Isacson O. Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome. Hippocampus. 13: 905-14. PMID 14750653 DOI: 10.1002/hipo.10130  0.45
2003 Bimonte-Nelson HA, Singleton RS, Hunter CL, Price KL, Moore AB, Granholm AC. Ovarian hormones and cognition in the aged female rat: I. Long-term, but not short-term, ovariectomy enhances spatial performance. Behavioral Neuroscience. 117: 1395-406. PMID 14674857 DOI: 10.1037/0735-7044.117.6.1395  0.678
2003 Zaman V, Li Z, Middaugh L, Ramamoorthy S, Rohrer B, Nelson ME, Tomac AC, Hoffer BJ, Gerhardt GA, Granholm ACh. The noradrenergic system of aged GDNF heterozygous mice. Cell Transplantation. 12: 291-303. PMID 12797383  0.737
2003 Bimonte-Nelson HA, Singleton RS, Nelson ME, Eckman CB, Barber J, Scott TY, Granholm AC. Testosterone, but not nonaromatizable dihydrotestosterone, improves working memory and alters nerve growth factor levels in aged male rats. Experimental Neurology. 181: 301-12. PMID 12782002 DOI: 10.1016/S0014-4886(03)00061-X  0.623
2003 Hunter CL, Isacson O, Nelson M, Bimonte-Nelson H, Seo H, Lin L, Ford K, Kindy MS, Granholm AC. Regional alterations in amyloid precursor protein and nerve growth factor across age in a mouse model of Down's syndrome. Neuroscience Research. 45: 437-45. PMID 12657457 DOI: 10.1016/S0168-0102(03)00005-1  0.733
2003 Albeck D, Mesches MH, Juthberg S, Browning M, Bickford PC, Rose GM, Granholm AC. Exogenous NGF restores endogenous NGF distribution in the brain of the cognitively impaired aged rat. Brain Research. 967: 306-10. PMID 12650994 DOI: 10.1016/S0006-8993(03)02272-8  0.789
2003 Bimonte-Nelson HA, Hunter CL, Nelson ME, Granholm AC. Frontal cortex BDNF levels correlate with working memory in an animal model of Down syndrome. Behavioural Brain Research. 139: 47-57. PMID 12642175 DOI: 10.1016/S0166-4328(02)00082-7  0.707
2003 Hunter CL, Bimonte HA, Granholm AC. Behavioral comparison of 4 and 6 month-old Ts65Dn mice: age-related impairments in working and reference memory. Behavioural Brain Research. 138: 121-31. PMID 12527443 DOI: 10.1016/S0166-4328(02)00275-9  0.527
2002 Granholm AC, Ford KA, Hyde LA, Bimonte HA, Hunter CL, Nelson M, Albeck D, Sanders LA, Mufson EJ, Crnic LS. Estrogen restores cognition and cholinergic phenotype in an animal model of Down syndrome. Physiology & Behavior. 77: 371-85. PMID 12419414 DOI: 10.1016/S0031-9384(02)00884-3  0.777
2002 McGrath J, Lintz E, Hoffer BJ, Gerhardt GA, Quintero EM, Granholm AC. Adeno-associated viral delivery of GDNF promotes recovery of dopaminergic phenotype following a unilateral 6-hydroxydopamine lesion. Cell Transplantation. 11: 215-27. PMID 12075987 DOI: 10.3727/096020198389988  0.7
2002 Isacson O, Seo H, Lin L, Albeck D, Granholm AC. Alzheimer's disease and Down's syndrome: roles of APP, trophic factors and ACh. Trends in Neurosciences. 25: 79-84. PMID 11814559 DOI: 10.1016/S0166-2236(02)02037-4  0.715
2001 Bickford PC, Bowenkamp K, Taglialatela G, Hoertig G, Granholm AC. GDNF improves cerebellar Purkinje neuron function in aged F344 rats. Microscopy Research and Technique. 54: 309-16. PMID 11514987 DOI: 10.1002/Jemt.1143  0.591
2001 Granholm AC, Helt C, Srivastava N, Backman C, Gerhardt GA. Effects of age and GDNF on noradrenergic innervation of the hippocampal formation: studies from intraocular grafts. Microscopy Research and Technique. 54: 298-308. PMID 11514986 DOI: 10.1002/jemt.1142  0.753
2001 Helt CE, Hoernig GR, Albeck DS, Gerhardt GA, Ickes B, Reyland ME, Quissell DO, Strömberg I, Granholm AC. Neuroprotection of grafted neurons with a GDNF/caspase inhibitor cocktail. Experimental Neurology. 170: 258-69. PMID 11476591 DOI: 10.1006/Exnr.2001.7709  0.779
2001 Palmer MR, Granholm AC, van Horne CG, Giardina KE, Freund RK, Moorhead JW, Gerhardt GA. Intranigral transplantation of solid tissue ventral mesencephalon or striatal grafts induces behavioral recovery in 6-OHDA-lesioned rats. Brain Research. 890: 86-99. PMID 11164771 DOI: 10.1016/S0006-8993(00)03084-5  0.502
2001 Granholm AC, Strömberg I. Introduction: Factors influencing neurite outgrowth and regeneration Microscopy Research and Technique. 54: 271-272. DOI: 10.1002/jemt.1139  0.769
2000 Zuch CL, Nordstroem VK, Briedrick LA, Hoernig GR, Granholm AC, Bickford PC. Time course of degenerative alterations in nigral dopaminergic neurons following a 6-hydroxydopamine lesion. The Journal of Comparative Neurology. 427: 440-54. PMID 11054705 DOI: 10.1002/1096-9861(20001120)427:3<440::AID-CNE10>3.0.CO;2-7  0.584
2000 Ickes BR, Pham TM, Sanders LA, Albeck DS, Mohammed AH, Granholm AC. Long-term environmental enrichment leads to regional increases in neurotrophin levels in rat brain. Experimental Neurology. 164: 45-52. PMID 10877914 DOI: 10.1006/exnr.2000.7415  0.727
2000 Granholm AC, Reyland M, Albeck D, Sanders L, Gerhardt G, Hoernig G, Shen L, Westphal H, Hoffer B. Glial cell line-derived neurotrophic factor is essential for postnatal survival of midbrain dopamine neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 3182-90. PMID 10777782 DOI: 10.1523/Jneurosci.20-09-03182.2000  0.73
2000 Granholm AC, Sanders LA, Crnic LS. Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndrome. Experimental Neurology. 161: 647-63. PMID 10686084 DOI: 10.1006/exnr.1999.7289  0.341
1999 Pham TM, Ickes B, Albeck D, Söderström S, Granholm AC, Mohammed AH. Changes in brain nerve growth factor levels and nerve growth factor receptors in rats exposed to environmental enrichment for one year. Neuroscience. 94: 279-86. PMID 10613518 DOI: 10.1016/S0306-4522(99)00316-4  0.712
1999 Albeck DS, Bäckman C, Veng L, Friden P, Rose GM, Granholm A. Acute application of NGF increases the firing rate of aged rat basal forebrain neurons. The European Journal of Neuroscience. 11: 2291-304. PMID 10383618 DOI: 10.1046/j.1460-9568.1999.00644.x  0.827
1999 Granholm AC, Sanders LA, Ickes B, Albeck D, Hoffer BJ, Young DA, Kaplan PL. Effects of osteogenic protein-1 (OP-1) treatment on fetal spinal cord transplants to the anterior chamber of the eye. Cell Transplantation. 8: 75-85. PMID 10338277  0.776
1998 Granholm AC, Henry S, Hebert MA, Eken S, Gerhard GA, Vanhorne C. KIDNEY COGRAFTS ENHANCE FIBER OUTGROWTH FROM VENTRAL MESENCEPHALIC GRAFTS TO THE 6-OHDA-LESIONED STRIATUM, AND IMPROVE BEHAVIORAL RECOVERY. Cell Transplantation. 7: 197-212. PMID 28234072  0.334
1998 Granholm AC, Albeck D, Bäckman C, Curtis M, Ebendal T, Friden P, Henry M, Hoffer B, Kordower J, Rose GM, Söderström S, Bartus RT. A non-invasive system for delivering neural growth factors across the blood-brain barrier: a review. Reviews in the Neurosciences. 9: 31-55. PMID 9683326 DOI: 10.1515/Revneuro.1998.9.1.31  0.825
1998 Granholm AC, Henry S, Herbert MA, Eken S, Gerhardt GA, van Horne C. Kidney cografts enhance fiber outgrowth from ventral mesencephalic grafts to the 6-OHDA-lesioned striatum, and improve behavioral recovery. Cell Transplantation. 7: 197-212. PMID 9588601 DOI: 10.1016/S0963-6897(97)00168-1  0.546
1997 Bäckman C, Rose GM, Bartus RT, Hoffer BJ, Mufson EJ, Granholm AC. Carrier mediated delivery of NGF: alterations in basal forebrain neurons in aged rats revealed using antibodies against low and high affinity NGF receptors. The Journal of Comparative Neurology. 387: 1-11. PMID 9331167 DOI: 10.1002/(Sici)1096-9861(19971013)387:1<1::Aid-Cne1>3.0.Co;2-5  0.777
1997 Granholm AC, Mott JL, Bowenkamp K, Eken S, Henry S, Hoffer BJ, Lapchak PA, Palmer MR, van Horne C, Gerhardt GA. Glial cell line-derived neurotrophic factor improves survival of ventral mesencephalic grafts to the 6-hydroxydopamine lesioned striatum. Experimental Brain Research. 116: 29-38. PMID 9305812 DOI: 10.1007/Pl00005741  0.711
1997 Albeck DS, Hoffer BJ, Quissell D, Sanders LA, Zerbe G, Granholm AC. A non-invasive transport system for GDNF across the blood-brain barrier. Neuroreport. 8: 2293-8. PMID 9243628 DOI: 10.1097/00001756-199707070-00039  0.77
1997 Srivastava N, Granholm AC, Gerhardt GA. Collateral sprouting of central noradrenergic neurons during aging: histochemical and neurochemical studies in intraocular triple transplants. Experimental Neurology. 145: 524-35. PMID 9217088 DOI: 10.1006/exnr.1997.6485  0.589
1997 Granholm AC, Srivastava N, Mott JL, Henry S, Henry M, Westphal H, Pichel JG, Shen L, Hoffer BJ. Morphological alterations in the peripheral and central nervous systems of mice lacking glial cell line-derived neurotrophic factor (GDNF): immunohistochemical studies. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 1168-78. PMID 8994069  0.651
1996 Granholm AE, Curtis M, Diamond DM, Branch BJ, Heman KL, Rose GM. DEVELOPMENT OF AN INTACT BLOOD-BRAIN BARRIER IN BRAIN TISSUE TRANSPLANTS IS DEPENDENT ON THE SITE OF TRANSPLANTATION. Cell Transplantation. 5: 305-314. PMID 28148381  0.481
1996 Pichel JG, Shen L, Sheng HZ, Granholm AC, Drago J, Grinberg A, Lee EJ, Huang SP, Saarma M, Hoffer BJ, Sariola H, Westphal H. GDNF is required for kidney development and enteric innervation. Cold Spring Harbor Symposia On Quantitative Biology. 61: 445-57. PMID 9246473  0.531
1996 Bowenkamp KE, David D, Lapchak PL, Henry MA, Granholm AC, Hoffer BJ, Mahalik TJ. 6-hydroxydopamine induces the loss of the dopaminergic phenotype in substantia nigra neurons of the rat. A possible mechanism for restoration of the nigrostriatal circuit mediated by glial cell line-derived neurotrophic factor. Experimental Brain Research. 111: 1-7. PMID 8891630 DOI: 10.1007/BF00229549  0.639
1996 Price ML, Hoffer BJ, Granholm AC. Effects of GDNF on fetal septal forebrain transplants in oculo. Experimental Neurology. 141: 181-9. PMID 8812151 DOI: 10.1006/exnr.1996.0152  0.644
1996 Bäckman C, Rose GM, Hoffer BJ, Henry MA, Bartus RT, Friden P, Granholm AC. Systemic administration of a nerve growth factor conjugate reverses age-related cognitive dysfunction and prevents cholinergic neuron atrophy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 5437-42. PMID 8757256 DOI: 10.1523/Jneurosci.16-17-05437.1996  0.783
1996 Granholm AC, Curtis M, Diamond DM, Branch BJ, Heman KL, Rose GM. Development of an intact blood-brain barrier in brain tissue transplants is dependent on the site of transplantation. Cell Transplantation. 5: 305-14. PMID 8689041 DOI: 10.1016/0963-6897(95)02037-3  0.481
1996 Pichel JG, Shen L, Sheng HZ, Granholm AC, Drago J, Grinberg A, Lee EJ, Huang SP, Saarma M, Hoffer BJ, Sariola H, Westphal H. Defects in enteric innervation and kidney development in mice lacking GDNF. Nature. 382: 73-6. PMID 8657307 DOI: 10.1038/382073a0  0.634
1995 Curtis M, Bergman H, Price ML, Srivastava N, Granholm AC. Hypothalamic tissue stimulates hippocampal pyramidal neuron survival during development: evidence from intraocular double transplants. Hippocampus. 5: 584-94. PMID 8646284 DOI: 10.1002/hipo.450050609  0.506
1995 Hudson J, Granholm AC, Gerhardt GA, Henry MA, Hoffman A, Biddle P, Leela NS, Mackerlova L, Lile JD, Collins F. Glial cell line-derived neurotrophic factor augments midbrain dopaminergic circuits in vivo. Brain Research Bulletin. 36: 425-32. PMID 7712205 DOI: 10.1016/0361-9230(94)00224-O  0.528
1995 Bergman H, Nagy JI, Granholm AC. Intracranial transplantation and survival of tuberomammillary histaminergic neurons. Neuroscience. 64: 61-70. PMID 7708215 DOI: 10.1016/0306-4522(94)00371-B  0.302
1995 Bowenkamp KE, Hoffman AF, Gerhardt GA, Henry MA, Biddle PT, Hoffer BJ, Granholm AC. Glial cell line-derived neurotrophic factor supports survival of injured midbrain dopaminergic neurons. The Journal of Comparative Neurology. 355: 479-89. PMID 7636027 DOI: 10.1002/Cne.903550402  0.708
1994 Granholm AC, Bäckman C, Bloom F, Ebendal T, Gerhardt GA, Hoffer B, Mackerlova L, Olson L, Söderström S, Walus LR. NGF and anti-transferrin receptor antibody conjugate: short and long-term effects on survival of cholinergic neurons in intraocular septal transplants. The Journal of Pharmacology and Experimental Therapeutics. 268: 448-59. PMID 8301587  0.766
1994 Freedman R, Strömberg I, Nordström AL, Seiger A, Olson L, Bygdeman M, Wiesel FA, Granholm AC, Hoffer BJ. Neuronal development in embryonic brain tissue derived from schizophrenic women and grafted to animal hosts. Schizophrenia Research. 13: 259-70. PMID 7841140 DOI: 10.1016/0920-9964(94)90051-5  0.65
1994 Granholm A, Biddle PT, Bäckman C, Ebendal T, Gerhardt G, Hoffer B, Mackerlova L, Olson L, Söderström S, Walus L, Friden P. Peripheral Administration of Nerve Growth Factor Conjugated to an Anti-transferrin Receptor Antibody Increases Cholinergic Neuron Survival in Intraocular Forebrain Transplants Methods in Neurosciences. 21: 71-92. DOI: 10.1016/B978-0-12-185291-7.50011-4  0.777
1993 Friden PM, Walus LR, Watson P, Doctrow SR, Kozarich JW, Bäckman C, Bergman H, Hoffer B, Bloom F, Granholm AC. Blood-brain barrier penetration and in vivo activity of an NGF conjugate. Science (New York, N.Y.). 259: 373-7. PMID 8420006 DOI: 10.1126/Science.8420006  0.74
1992 Backman C, Granholm AC. Effects of ethanol on development of dorsal raphe transplants in oculo: a morphological and electrophysiological study. The Journal of Comparative Neurology. 320: 136-44. PMID 1401240 DOI: 10.1002/cne.903200110  0.64
1992 Granholm AC, Gerhardt GA, Bygdeman M, Strömberg I. Human fetal xenografts of brainstem tissue containing locus coeruleus neurons: functional and structural studies of intraocular grafts in athymic nude rats. Experimental Neurology. 118: 7-17. PMID 1397178 DOI: 10.1016/0014-4886(92)90017-K  0.516
1992 Hall M, Wang Y, Granholm AC, Stevens JO, Young D, Hoffer BJ. Comparison of fetal rabbit brain xenografts to three different strains of athymic nude rats: electrophysiological and immunohistochemical studies of intraocular grafts. Cell Transplantation. 1: 71-82. PMID 1344293  0.634
1991 Gerhardt GA, Palmer MR, Granholm AC. Age-induced changes in single locus coeruleus brain transplants grown in oculo: an in vivo electrochemical study. Neurobiology of Aging. 12: 487-94. PMID 1685219 DOI: 10.1016/0197-4580(91)90078-X  0.581
1990 Palmer MR, Eriksdotter-Nilsson M, Bygdeman M, Stieg P, Strömberg I, Olson L, Seiger A, Hoffer BJ, Granholm AC. Electrophysiologic effects of ethanol in human brain xenografts in oculo: antagonism by Ro15-4513. The Journal of Pharmacology and Experimental Therapeutics. 254: 1100-6. PMID 2395107  0.666
1990 Granholm AC, Bergman H, Mackerlova L, Blomqvist A. Intraocular hypothalamic transplants containing histaminergic neurons: innervation of host iris and hippocampal cografts. Experimental Neurology. 108: 189-97. PMID 1693577 DOI: 10.1016/0014-4886(90)90123-A  0.376
1989 Granholm AC, Eriksdotter-Nilsson M, Strömberg I, Stieg P, Seiger A, Bygdeman M, Geffard M, Oertel W, Dahl D, Olson L. Morphological and electrophysiological studies of human hippocampal transplants in the anterior eye chamber of athymic nude rats. Experimental Neurology. 104: 162-71. PMID 2707363 DOI: 10.1016/S0014-4886(89)80010-X  0.46
1989 Mahalik TJ, Strömberg I, Gerhardt GA, Granholm AC, Seiger A, Bygdeman M, Olson L, Hoffer BJ, Finger TE. Human ventral mesencephalic xenografts to the catecholamine-depleted striata of athymic rats: ultrastructure and immunocytochemistry. Synapse (New York, N.Y.). 4: 19-29. PMID 2570467 DOI: 10.1002/syn.890040104  0.796
1989 Eriksdotter-Nilsson M, Gerhardt G, Seiger A, Olson L, Hoffer B, Granholm AC. Age-related alterations in noradrenergic input to the hippocampal formation: structural and functional studies in intraocular transplants. Brain Research. 478: 269-80. PMID 2564300 DOI: 10.1016/0006-8993(89)91507-2  0.582
1989 Strömberg I, Almqvist P, Bygdeman M, Finger TE, Gerhardt G, Granholm AC, Mahalik TJ, Seiger A, Olson L, Hoffer B. Human fetal mesencephalic tissue grafted to dopamine-denervated striatum of athymic rats: light- and electron-microscopical histochemistry and in vivo chronoamperometric studies. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 9: 614-24. PMID 2563765 DOI: 10.1523/Jneurosci.09-02-00614.1989  0.797
1989 Eriksdotter-Nilsson M, Gerhardt G, Seiger A, Hoffer B, Granholm AC. Multiple changes in noradrenergic mechanisms in the coeruleo-hippocampal pathway during aging. Structural and functional correlates in intraocular double grafts. Neurobiology of Aging. 10: 117-24. PMID 2542818 DOI: 10.1016/0197-4580(89)90020-1  0.715
1988 Hoffer BJ, Granholm AC, Stevens JO, Olson L. Catecholamine-containing grafts in parkinsonism: past and present. Clinical Research. 36: 189-95. PMID 3286096  0.638
1988 Hoffer B, Bickford-Wimer P, Bygdeman M, Granholm AC, Olson L, Seiger A, Stevens J, Strömberg I. Electrophysiological studies of human cerebral and cerebellar cortical tissue grafted to the anterior eye chamber of athymic rodents. Progress in Brain Research. 78: 591-7. PMID 3247454 DOI: 10.1016/S0079-6123(08)60335-0  0.662
1988 Bickford-Wimer PC, Granholm AC, Gerhardt GA. Cerebellar noradrenergic systems in aging: studies in situ and in in oculo grafts. Neurobiology of Aging. 9: 591-9. PMID 3211262 DOI: 10.1016/S0197-4580(88)80118-0  0.502
1988 Granholm AC, Gerhardt GA, Moore E, Eriksdotter-Nilsson M, Nylén P, Johnson AC, Henschen A, Shirley MA, Palmer MR, Hoffer BJ. Toluene exposure during maturation of intraocular brain tissue transplants: alterations of host and graft cerebellar Purkinje neuron function and sensitivity to norepinephrine. Toxicology and Applied Pharmacology. 96: 296-304. PMID 3194916 DOI: 10.1016/0041-008X(88)90088-9  0.709
1988 Strömberg I, Almqvist P, Bygdeman M, Finger TE, Gerhardt G, Granholm AC, Mahalik TJ, Seiger A, Hoffer B, Olson L. Intracerebral xenografts of human mesencephalic tissue into athymic rats: immunochemical and in vivo electrochemical studies. Proceedings of the National Academy of Sciences of the United States of America. 85: 8331-4. PMID 3186728 DOI: 10.1073/Pnas.85.21.8331  0.807
1987 Granholm AC, Gerhardt GA, Eriksdotter-Nilsson M, Bickford-Wimer PC, Palmer MR, Seiger A, Olson L, Hoffer BJ. Age-related changes in cerebellar noradrenergic pre- and postsynaptic mechanisms: intrinsic vs extrinsic determinants evaluated with brain grafts in oculo. Brain Research. 423: 71-8. PMID 3676821 DOI: 10.1016/0006-8993(87)90826-2  0.735
1987 Hall ME, Granholm AC, Stevens JO, Hoffer BJ. Myocardium and cortex cerebri xenografts transplanted into the anterior chamber of the eye of athymic rats: a morphologic and electrophysiologic profile. Neuroscience Letters. 75: 89-94. PMID 3554011 DOI: 10.1016/0304-3940(87)90081-4  0.6
1987 Bickford-Wimer P, Granholm AC, Bygdeman M, Hoffer B, Olson L, Seiger A, Strömberg I. Human fetal cerebellar and cortical tissue transplanted to the anterior eye chamber of athymic rats: electrophysiological and structural studies. Proceedings of the National Academy of Sciences of the United States of America. 84: 5957-61. PMID 3475712 DOI: 10.1073/PNAS.84.16.5957  0.677
1987 Olson L, Strömberg I, Bygdeman M, Granholm AC, Hoffer B, Freedman R, Seiger A. Human fetal tissues grafted to rodent hosts: structural and functional observations of brain, adrenal and heart tissues in oculo. Experimental Brain Research. 67: 163-78. PMID 3305059 DOI: 10.1007/Bf00269464  0.479
1986 Granholm AC, Almqvist P, Seiger A, Olson L. Thy-1-like immunoreactivity in human brain during development. Brain Research Bulletin. 17: 107-15. PMID 2875772 DOI: 10.1016/0361-9230(86)90166-8  0.362
1986 Seiger A, Almqvist P, Granholm AC, Olson L. On the localization of Thy-1-like immunoreactivity in the rodent and human nervous system. Medical Biology. 64: 109-17. PMID 2875228  0.442
1985 Granholm AC, Almqvist P, Seiger A, Olson L. Distribution of Thy-1-like immunoreactivity in normal, sympathetically denervated and grafted mouse irides. Histochemistry. 82: 107-11. PMID 2860083 DOI: 10.1007/BF00708193  0.401
1982 Granholm AC, Olson L, Seiger A. Intraocular development and adrenergic innervation of cortical and subcortical brain areas: influence of thyroid hormone deficiency. Developmental Neuroscience. 5: 436-46. PMID 7160309 DOI: 10.1159/000112704  0.504
1982 Mikoshiba K, Yokoyama M, Takamatsu K, Lysz TW, Alderson RF, Sze PY, Burrage TG, Lentz TL, Druse MJ, Unsicker K, Millar TJ, Hofmann H, Lauder JM, Zimmerman EF, Bulger JE, ... ... Granholm A, et al. Contents Vol. 5, 1982 Developmental Neuroscience. 5. DOI: 10.1159/000112720  0.361
1982 Mikoshiba K, Yokoyama M, Takamatsu K, Lysz TW, Alderson RF, Sze PY, Burrage TG, Lentz TL, Druse MJ, Unsicker K, Millar TJ, Hofmann H, Lauder JM, Zimmerman EF, Bulger JE, ... ... Granholm A, et al. Subject Index Vol. 5, 1982 Developmental Neuroscience. 5: 569-570. DOI: 10.1159/000112719  0.353
Show low-probability matches.