Ann-Charlotte Granholm - Publications

MUSC, Santa Clara, Villa Clara, Cuba 
aging, dopamine, neurodegeneration

210 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Alldred MJ, Martini AC, Patterson D, Hendrix J, Granholm AC. Aging with Down Syndrome-Where Are We Now and Where Are We Going? Journal of Clinical Medicine. 10. PMID 34682809 DOI: 10.3390/jcm10204687  1
2021 Ledreux A, Thomas S, Hamlett ED, Trautman C, Gilmore A, Rickman Hager E, Paredes DA, Margittai M, Fortea J, Granholm AC. Small Neuron-Derived Extracellular Vesicles from Individuals with Down Syndrome Propagate Tau Pathology in the Wildtype Mouse Brain. Journal of Clinical Medicine. 10. PMID 34501378 DOI: 10.3390/jcm10173931  1
2021 Granholm AC, Ledreux A. Biomarkers show value of studying dementia in Down syndrome. Nature Reviews. Neurology. PMID 34465922 DOI: 10.1038/s41582-021-00558-w  1
2021 Hendrix JA, Amon A, Abbeduto L, Agiovlasitis S, Alsaied T, Anderson HA, Bain LJ, Baumer N, Bhattacharyya A, Bogunovic D, Botteron KN, Capone G, Chandan P, Chase I, Chicoine B, ... ... Granholm AC, et al. Opportunities, barriers, and recommendations in down syndrome research. Translational Science of Rare Diseases. 5: 99-129. PMID 34268067 DOI: 10.3233/trd-200090  1
2021 Haytural H, Jordà-Siquier T, Winblad B, Mulle C, Tjernberg LO, Granholm AC, Frykman S, Barthet G. Distinctive alteration of presynaptic proteins in the outer molecular layer of the dentate gyrus in Alzheimer's disease. Brain Communications. 3: fcab079. PMID 34013204 DOI: 10.1093/braincomms/fcab079  1
2021 Grossberg AN, Koza LA, Ledreux A, Prusmack C, Krishnamurthy HK, Jayaraman V, Granholm AC, Linseman DA. A multiplex chemiluminescent immunoassay for serological profiling of COVID-19-positive symptomatic and asymptomatic patients. Nature Communications. 12: 740. PMID 33531472 DOI: 10.1038/s41467-021-21040-7  1
2020 Mason SJ, Davidson BS, Lehto M, Ledreux A, Granholm AC, Gorgens KA. A Cohort Study of the Temporal Stability of ImPACT Scores Among NCAA Division I Collegiate Athletes: Clinical Implications of Test-Retest Reliability for Enhancing Student Athlete Safety. Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists. PMID 32853329 DOI: 10.1093/Arclin/Acaa047  1
2020 Ledreux A, Pryhoda MK, Gorgens K, Shelburne K, Gilmore A, Linseman DA, Fleming H, Koza LA, Campbell J, Wolff A, Kelly JP, Margittai M, Davidson BS, Granholm AC. Assessment of Long-Term Effects of Sports-Related Concussions: Biological Mechanisms and Exosomal Biomarkers. Frontiers in Neuroscience. 14: 761. PMID 32848549 DOI: 10.3389/Fnins.2020.00761  1
2020 Pryhoda MK, Shelburne KB, Gorgens K, Ledreux A, Granholm AC, Davidson BS. Centre of pressure velocity shows impairments in NCAA Division I athletes six months post-concussion during standing balance. Journal of Sports Sciences. 1-11. PMID 32715955 DOI: 10.1080/02640414.2020.1795561  1
2020 Snyder HM, Bain LJ, Brickman AM, Carrillo MC, Esbensen AJ, Espinosa JM, Fernandez F, Fortea J, Hartley SL, Head E, Hendrix J, Kishnani PS, Lai F, Lao P, Lemere C, ... ... Granholm AC, et al. Further understanding the connection between Alzheimer's disease and Down syndrome. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 32544310 DOI: 10.1002/Alz.12112  1
2020 Hamlett ED, Hjorth E, Ledreux A, Gilmore A, Schultzberg M, Granholm AC. RvE1 treatment prevents memory loss and neuroinflammation in the Ts65Dn mouse model of Down syndrome. Glia. PMID 31944407 DOI: 10.1002/glia.23779  1
2020 Goetzl EJ, Yaffe K, Peltz CB, Ledreux A, Gorgens K, Davidson B, Granholm AC, Mustapic M, Kapogiannis D, Tweedie D, Greig NH. Traumatic brain injury increases plasma astrocyte-derived exosome levels of neurotoxic complement proteins. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 31916313 DOI: 10.1096/Fj.201902842R  1
2020 Emre C, Hjorth E, Bharani K, Carroll S, Granholm AC, Schultzberg M. Receptors for pro-resolving mediators are increased in Alzheimer's disease brain. Brain Pathology (Zurich, Switzerland). PMID 31912564 DOI: 10.1111/Bpa.12812  1
2020 Ledreux A, Pryhoda MK, Gorgens K, Shelburne K, Gilmore A, Linseman DA, Fleming H, Koza LA, Campbell J, Wolff A, Kelly JP, Margittai M, Davidson BS, Granholm A. Assessment of Long-Term Effects of Sports-Related Concussions: Biological Mechanisms and Exosomal Biomarkers Frontiers in Neuroscience. 14. DOI: 10.3389/fnins.2020.00761  0.01
2020 Hamlett ED, Carroll SL, Granholm A. The role of calbindin‐D28k in a mouse model of Down syndrome‐related Alzheimer's disease Alzheimer's & Dementia. 16. DOI: 10.1002/alz.042295  0.01
2020 Sandberg AA, Johnson A, Fudge D, Melgar S, Hicks C, Patterson D, Vacano G, Margittai M, Weismiller H, Harvey S, Hernandez L, Caviedes P, Ledreux A, Qin Y, Granholm A, et al. AB42 and polyamines: Elucidating a potential mechanism of amyloid‐mediated apoptosis and aggregation Alzheimer's & Dementia. 16. DOI: 10.1002/alz.039915  0.01
2019 Bharani KL, Ledreux A, Gilmore A, Carroll SL, Granholm AC. Serum pro-BDNF levels correlate with phospho-tau staining in Alzheimer's disease. Neurobiology of Aging. PMID 31882186 DOI: 10.1016/J.Neurobiolaging.2019.11.010  1
2019 Haytural H, Mermelekas G, Emre C, Nigam SM, Carroll SL, Winblad B, Bogdanovic N, Barthet G, Granholm AC, Orre LM, Tjernberg LO, Frykman S. The proteome of the dentate terminal zone of the perforant path indicates presynaptic impairment in Alzheimer disease. Molecular & Cellular Proteomics : McP. PMID 31699905 DOI: 10.1074/Mcp.Ra119.001737  1
2019 Hamlett ED, Ledreux A, Gilmore A, Vazey EM, Aston-Jones G, Boger HA, Paredes D, Granholm AE. Inhibitory designer receptors aggravate memory loss in a mouse model of down syndrome. Neurobiology of Disease. 134: 104616. PMID 31678403 DOI: 10.1016/J.Nbd.2019.104616  1
2019 Ledreux A, Hkansson K, Carlsson R, Kidane M, Columbo L, Terjestam Y, Ryan E, Tusch E, Winblad B, Daffner K, Granholm AC, Mohammed AKH. Differential Effects of Physical Exercise, Cognitive Training, and Mindfulness Practice on Serum BDNF Levels in Healthy Older Adults: A Randomized Controlled Intervention Study. Journal of Alzheimer's Disease : Jad. PMID 31498125 DOI: 10.3233/Jad-190756  1
2019 Hamlett ED, LaRosa A, Mufson EJ, Fortea J, Ledreux A, Granholm AC. Exosome release and cargo in Down syndrome. Developmental Neurobiology. PMID 31347291 DOI: 10.1002/dneu.22712  1
2019 Goetzl EJ, Ledreux A, Granholm AC, Elahi FM, Goetzl L, Hiramoto J, Kapogiannis D. Neuron-Derived Exosome Proteins May Contribute to Progression From Repetitive Mild Traumatic Brain Injuries to Chronic Traumatic Encephalopathy. Frontiers in Neuroscience. 13: 452. PMID 31133789 DOI: 10.3389/fnins.2019.00452  1
2017 Bharani KL, Derex R, Granholm AC, Ledreux A. A noradrenergic lesion aggravates the effects of systemic inflammation on the hippocampus of aged rats. Plos One. 12: e0189821. PMID 29261743 DOI: 10.1371/Journal.Pone.0189821  1
2017 Buhusi M, Etheredge C, Granholm AC, Buhusi CV. Increased Hippocampal ProBDNF Contributes to Memory Impairments in Aged Mice. Frontiers in Aging Neuroscience. 9: 284. PMID 28912711 DOI: 10.3389/Fnagi.2017.00284  1
2017 Hamlett ED, Ledreux A, Potter H, Chial HJ, Patterson D, Espinosa JM, Bettcher BM, Granholm AC. EXOSOMAL BIOMARKERS IN DOWN SYNDROME AND ALZHEIMER'S DISEASE. Free Radical Biology & Medicine. PMID 28882786 DOI: 10.1016/J.Freeradbiomed.2017.08.028  1
2016 Hamlett ED, Goetzl EJ, Ledreux A, Vasilevko V, Boger HA, LaRosa A, Clark D, Carroll SL, Carmona Iragui M, Fortea J, Mufson EJ, Sabbagh M, Mohammed AH, Hartley D, Doran E, ... ... Granholm AC, et al. Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 27755974 DOI: 10.1016/j.jalz.2016.08.012  1
2016 Håkansson K, Ledreux A, Daffner K, Terjestam Y, Bergman P, Carlsson R, Kivipelto M, Winblad B, Granholm AC, Mohammed AK. BDNF Responses in Healthy Older Persons to 35 Minutes of Physical Exercise, Cognitive Training, and Mindfulness: Associations with Working Memory Function. Journal of Alzheimer's Disease : Jad. PMID 27716670 DOI: 10.3233/Jad-160593  1
2016 Ledreux A, Wang X, Schultzberg M, Granholm AC, Freeman LR. Detrimental effects of a high fat/high cholesterol diet on memory and hippocampal markers in aged rats. Behavioural Brain Research. PMID 27343935 DOI: 10.1016/j.bbr.2016.06.012  1
2016 Rosenberger DS, Falangola MF, Ledreux A, Nie X, Suhre WM, Boger HA, Granholm AC. MEMORY AND HIPPOCAMPAL ARCHITECTURE FOLLOWING SHORT-TERM MIDAZOLAM IN WESTERN DIET-TREATED RATS. Neuroscience Letters. PMID 27080429 DOI: 10.1016/j.neulet.2016.04.021  1
2015 Spratt EG, Granholm AC, Carpenter LA, Boger HA, Papa CE, Logan S, Chaudhary H, Boatwright SW, Brady KT. Pilot Study and Review: Physiological Differences in BDNF, a Potential Biomarker in Males and Females with Autistic Disorder. International Neuropsychiatric Disease Journal. 3: 19-26. PMID 26866045 DOI: 10.9734/INDJ/2015/12118  1
2015 Zhu M, Wang X, Hjorth E, Colas RA, Schroeder L, Granholm AC, Serhan CN, Schultzberg M. Pro-Resolving Lipid Mediators Improve Neuronal Survival and Increase Aβ42 Phagocytosis. Molecular Neurobiology. PMID 26650044 DOI: 10.1007/S12035-015-9544-0  1
2015 Ledreux A, Boger HA, Hinson VK, Cantwell K, Granholm AC. BDNF levels are increased by aminoindan and rasagiline in a double lesion model of Parkinson׳s disease. Brain Research. PMID 26607251 DOI: 10.1016/j.brainres.2015.11.028  1
2015 Hamlett E, Boger HA, Ledreux A, Kelley CM, Mufson EJ, Falangola MF, Guilfoyle DN, Nixon RA, Patterson D, Duval N, Granholm AE. Cognitive Impairment, Neuroimaging, and Alzheimer Neuropathology in Mouse Models of Down Syndrome. Current Alzheimer Research. PMID 26391050 DOI: 10.2174/1567205012666150921095505  1
2015 Keren NI, Taheri S, Vazey EM, Morgan PS, Granholm AC, Aston-Jones GS, Eckert MA. Histologic validation of locus coeruleus MRI contrast in post-mortem tissue. Neuroimage. 113: 235-45. PMID 25791783 DOI: 10.1016/J.Neuroimage.2015.03.020  1
2015 Fortress AM, Hamlett ED, Vazey EM, Aston-Jones G, Cass WA, Boger HA, Granholm AC. Designer receptors enhance memory in a mouse model of Down syndrome. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 1343-53. PMID 25632113 DOI: 10.1523/Jneurosci.2658-14.2015  1
2015 Nie X, Hamlett ED, Granholm AC, Hui ES, Helpern JA, Jensen JH, Boger HA, Collins HR, Falangola MF. Evidence of altered age-related brain cytoarchitecture in mouse models of down syndrome: a diffusional kurtosis imaging study. Magnetic Resonance Imaging. 33: 437-47. PMID 25527393 DOI: 10.1016/J.Mri.2014.12.008  1
2015 Hartley D, Blumenthal T, Carrillo M, DiPaolo G, Esralew L, Gardiner K, Granholm AC, Iqbal K, Krams M, Lemere C, Lott I, Mobley W, Ness S, Nixon R, Potter H, et al. Down syndrome and Alzheimer's disease: Common pathways, common goals. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: 700-9. PMID 25510383 DOI: 10.1016/J.Jalz.2014.10.007  1
2015 Albers MW, Gilmore GC, Kaye J, Murphy C, Wingfield A, Bennett DA, Boxer AL, Buchman AS, Cruickshanks KJ, Devanand DP, Duffy CJ, Gall CM, Gates GA, Granholm AC, Hensch T, et al. At the interface of sensory and motor dysfunctions and Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: 70-98. PMID 25022540 DOI: 10.1016/J.Jalz.2014.04.514  1
2015 Wang X, Zhu M, Hjorth E, Cortés-Toro V, Eyjolfsdottir H, Graff C, Nennesmo I, Palmblad J, Eriksdotter M, Sambamurti K, Fitzgerald JM, Serhan CN, Granholm AC, Schultzberg M. Resolution of inflammation is altered in Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: 40-50.e1-2. PMID 24530025 DOI: 10.1016/J.Jalz.2013.12.024  1
2015 Granholm AH, Olsson H, Nilsson M, Allard A, Holmgren J. The potential of digital surface models based on aerial images for automated vegetation mapping International Journal of Remote Sensing. 36: 1855-1870. DOI: 10.1080/01431161.2015.1029094  1
2014 Cunningham MA, Wirth JR, Freeman LR, Boger HA, Granholm AC, Gilkeson GS. Estrogen receptor alpha deficiency protects against development of cognitive impairment in murine lupus. Journal of Neuroinflammation. 11: 171. PMID 25510908 DOI: 10.1186/S12974-014-0171-X  1
2014 Turan TN, Rumboldt Z, Granholm AC, Columbo L, Welsh CT, Lopes-Virella MF, Spampinato MV, Brown TR. Intracranial atherosclerosis: correlation between in-vivo 3T high resolution MRI and pathology. Atherosclerosis. 237: 460-3. PMID 25463074 DOI: 10.1016/J.Atherosclerosis.2014.10.007  1
2014 Karakostas T, Granholm AC. Motion capture and associated novel measurement devices for movement function in humans and animal models. Journal of Neuroscience Methods. 231: 1-2. PMID 24930468 DOI: 10.1016/j.jneumeth.2014.05.028  1
2014 Iulita MF, Do Carmo S, Ower AK, Fortress AM, Aguilar LF, Hanna M, Wisniewski T, Granholm AC, Buhusi M, Busciglio J, Cuello AC. Nerve growth factor metabolic dysfunction in Down's syndrome brains. Brain : a Journal of Neurology. 137: 860-72. PMID 24519975 DOI: 10.1093/Brain/Awt372  1
2014 Freeman LR, Haley-Zitlin V, Rosenberger DS, Granholm AC. Damaging effects of a high-fat diet to the brain and cognition: a review of proposed mechanisms. Nutritional Neuroscience. 17: 241-51. PMID 24192577 DOI: 10.1179/1476830513Y.0000000092  1
2014 Karakostas T, Hsiang S, Boger H, Middaugh L, Granholm AC. Three-dimensional rodent motion analysis and neurodegenerative disorders. Journal of Neuroscience Methods. 231: 31-7. PMID 24129039 DOI: 10.1016/J.Jneumeth.2013.09.009  1
2014 H Turner T. Epidermal Growth Factor (EGF) is Associated with Memory and Executive Functioning in Progressed Parkinson’s Disease Journal of Alzheimer's Disease & Parkinsonism. 4. DOI: 10.4172/2161-0460.1000164  0.01
2014 Wang X, Granholm A, Fitzgerald JM, Serhan CN, Schultzberg M. P1-099: ALTERED LIPID MEDIATORS AND RECEPTORS OF RESOLUTION IN THE ENTORHINAL CORTEX OF ALZHEIMER'S DISEASE Alzheimer's & Dementia. 10: P338-P338. DOI: 10.1016/J.Jalz.2014.05.335  0.01
2013 Littrell OM, Granholm AC, Gerhardt GA, Boger HA. Glial cell-line derived neurotrophic factor (GDNF) replacement attenuates motor impairments and nigrostriatal dopamine deficits in 12-month-old mice with a partial deletion of GDNF. Pharmacology, Biochemistry, and Behavior. 104: 10-9. PMID 23290934 DOI: 10.1016/J.Pbb.2012.12.022  1
2013 Tatters AO, Flewelling LJ, Fu F, Granholm AA, Hutchins DA. High CO2 promotes the production of paralytic shellfish poisoning toxins by Alexandrium catenella from Southern California waters Harmful Algae. 30: 37-43. DOI: 10.1016/j.hal.2013.08.007  1
2012 Zhang Y, Granholm AC, Huh K, Shan L, Diaz-Ruiz O, Malik N, Olson L, Hoffer BJ, Lupica CR, Hoffman AF, Bäckman CM. PTEN deletion enhances survival, neurite outgrowth and function of dopamine neuron grafts to MitoPark mice. Brain : a Journal of Neurology. 135: 2736-49. PMID 22961549 DOI: 10.1093/Brain/Aws196  1
2012 Lockrow JP, Fortress AM, Granholm AC. Age-related neurodegeneration and memory loss in down syndrome. Current Gerontology and Geriatrics Research. 2012: 463909. PMID 22545043 DOI: 10.1155/2012/463909  1
2012 Freeman LR, Granholm AC. Vascular changes in rat hippocampus following a high saturated fat and cholesterol diet. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 32: 643-53. PMID 22108721 DOI: 10.1038/jcbfm.2011.168  1
2012 Littrell OM, Pomerleau F, Huettl P, Surgener S, McGinty JF, Middaugh LD, Granholm AC, Gerhardt GA, Boger HA. Enhanced dopamine transporter activity in middle-aged Gdnf heterozygous mice. Neurobiology of Aging. 33: 427.e1-14. PMID 21144620 DOI: 10.1016/J.Neurobiolaging.2010.10.013  1
2012 M Vazey E. Norepinephrine in Neurodegeneration: A Coerulean Target Journal of Alzheimer's Disease & Parkinsonism. 2. DOI: 10.4172/2161-0460.1000E114  0.01
2012 Granholm A. Alzheimer’s Disease and Down Syndrome: Developing a National Tissue Repository Journal of Alzheimer's Disease & Parkinsonism. 2. DOI: 10.4172/2161-0460.1000E108  0.01
2012 Nordkvist K, Granholm AH, Holmgren J, Olsson H, Nilsson M. Combining optical satellite data and airborne laser scanner data for vegetation classification Remote Sensing Letters. 3: 393-401. DOI: 10.1080/01431161.2011.606240  1
2012 Alanis M, Umphlet C, Boger H, Granholm A. 426: Adolescent cognitive and anxiety behavior in offspring following in utero exposure to increased trans unsaturated fatty acids through maternal diet American Journal of Obstetrics and Gynecology. 206: S197. DOI: 10.1016/J.AJOG.2011.10.444  0.01
2011 Wiley MK, Granholm AC, Bachman D, Wieland D, Roberts E, Hardin R, Dever-Bumba M, Eleazer GP. Use of seniors as mentors to medical students: a collaboration between the University of South Carolina School of Medicine and the Medical University of South Carolina. Journal of the South Carolina Medical Association (1975). 107: 8-12. PMID 22057643  1
2011 Fortress AM, Buhusi M, Helke KL, Granholm AC. Cholinergic Degeneration and Alterations in the TrkA and p75NTR Balance as a Result of Pro-NGF Injection into Aged Rats. Journal of Aging Research. 2011: 460543. PMID 21785728 DOI: 10.4061/2011/460543  1
2011 Freeman LR, Haley-Zitlin V, Stevens C, Granholm AC. Diet-induced effects on neuronal and glial elements in the middle-aged rat hippocampus. Nutritional Neuroscience. 14: 32-44. PMID 21535919 DOI: 10.1179/174313211X12966635733358  1
2011 Freeman LR, Small BJ, Bickford PC, Umphlet C, Granholm AC. A high-fat/high-cholesterol diet inhibits growth of fetal hippocampal transplants via increased inflammation. Cell Transplantation. 20: 1499-514. PMID 21396159 DOI: 10.3727/096368910X557281  1
2011 Lockrow J, Boger H, Gerhardt G, Aston-Jones G, Bachman D, Granholm AC. A noradrenergic lesion exacerbates neurodegeneration in a Down syndrome mouse model. Journal of Alzheimer's Disease : Jad. 23: 471-89. PMID 21098982 DOI: 10.3233/JAD-2010-101218  1
2011 Granholm AC, Zaman V, Godbee J, Smith M, Ramadan R, Umphlet C, Randall P, Bhat NR, Rohrer B, Middaugh LD, Boger HA. Prenatal LPS increases inflammation in the substantia nigra of Gdnf heterozygous mice. Brain Pathology (Zurich, Switzerland). 21: 330-48. PMID 20969653 DOI: 10.1111/J.1750-3639.2010.00457.X  1
2011 Boger HA, Mannangatti P, Samuvel DJ, Saylor AJ, Bender TS, McGinty JF, Fortress AM, Zaman V, Huang P, Middaugh LD, Randall PK, Jayanthi LD, Rohrer B, Helke KL, Granholm AC, et al. Effects of brain-derived neurotrophic factor on dopaminergic function and motor behavior during aging. Genes, Brain, and Behavior. 10: 186-98. PMID 20860702 DOI: 10.1111/J.1601-183X.2010.00654.X  1
2011 Lockrow J, Boger H, Bimonte-Nelson H, Granholm AC. Effects of long-term memantine on memory and neuropathology in Ts65Dn mice, a model for Down syndrome. Behavioural Brain Research. 221: 610-22. PMID 20363261 DOI: 10.1016/j.bbr.2010.03.036  1
2010 Granholm AC. Why do we need to use animal models to study cognition and aging? Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 1621-2. PMID 20551899 DOI: 10.1038/npp.2010.45  1
2010 Willis LM, Freeman L, Bickford PC, Quintero EM, Umphlet CD, Moore AB, Goetzl L, Granholm AC. Blueberry supplementation attenuates microglial activation in hippocampal intraocular grafts to aged hosts. Glia. 58: 679-90. PMID 20014277 DOI: 10.1002/glia.20954  1
2010 Boger HA, Granholm AC, McGinty JF, Middaugh LD. A dual-hit animal model for age-related parkinsonism. Progress in Neurobiology. 90: 217-29. PMID 19853012 DOI: 10.1016/J.Pneurobio.2009.10.013  1
2010 Granholm AC, Skirboll L, Schultzberg M. Chemical signaling in the nervous system in health and disease: Nils-Ake Hillarp's legacy. Progress in Neurobiology. 90: 71-4. PMID 19850101 DOI: 10.1016/j.pneurobio.2009.10.006  1
2010 Granholm AE, Freeman L. P4-036: Long-term Treatment With a High-fat Diet Causes Memory Loss and Breached Blood-brain Barrier in Aged Rats. Alzheimer's & Dementia. 6: e31-e31. DOI: 10.1016/j.jalz.2010.08.096  0.01
2010 Flewelling LJ, Adams DH, Naar JP, Atwood KE, Granholm AA, O'Dea SN, Landsberg JH. Brevetoxins in sharks and rays (Chondrichthyes, Elasmobranchii) from Florida coastal waters Marine Biology. 157: 1937-1953. DOI: 10.1007/s00227-010-1463-z  1
2009 Lockrow J, Prakasam A, Huang P, Bimonte-Nelson H, Sambamurti K, Granholm AC. Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model. Experimental Neurology. 216: 278-89. PMID 19135442 DOI: 10.1016/J.Expneurol.2008.11.021  1
2009 Boger HA, Middaugh LD, Granholm AC, McGinty JF. Minocycline restores striatal tyrosine hydroxylase in GDNF heterozygous mice but not in methamphetamine-treated mice. Neurobiology of Disease. 33: 459-66. PMID 19110059 DOI: 10.1016/J.Nbd.2008.11.013  1
2008 Granholm AC, Boger H, Emborg ME. Mood, memory and movement: an age-related neurodegenerative complex? Current Aging Science. 1: 133-9. PMID 20021382 DOI: 10.2174/1874609810801020133  1
2008 Zaman V, Boger HA, Granholm AC, Rohrer B, Moore A, Buhusi M, Gerhardt GA, Hoffer BJ, Middaugh LD. The nigrostriatal dopamine system of aging GFRalpha-1 heterozygous mice: neurochemistry, morphology and behavior. The European Journal of Neuroscience. 28: 1557-68. PMID 18973577 DOI: 10.1111/J.1460-9568.2008.06456.X  1
2008 Boger HA, Middaugh LD, Zaman V, Hoffer B, Granholm AC. Differential effects of the dopamine neurotoxin MPTP in animals with a partial deletion of the GDNF receptor, GFR alpha1, gene. Brain Research. 1241: 18-28. PMID 18822276 DOI: 10.1016/J.Brainres.2008.09.011  1
2008 Granholm AC, Bimonte-Nelson HA, Moore AB, Nelson ME, Freeman LR, Sambamurti K. Effects of a saturated fat and high cholesterol diet on memory and hippocampal morphology in the middle-aged rat. Journal of Alzheimer's Disease : Jad. 14: 133-45. PMID 18560126 DOI: 10.3233/Jad-2008-14202  1
2008 Liu Y, Qin L, Wilson B, Wu X, Qian L, Granholm AC, Crews FT, Hong JS. Endotoxin induces a delayed loss of TH-IR neurons in substantia nigra and motor behavioral deficits. Neurotoxicology. 29: 864-70. PMID 18471886 DOI: 10.1016/j.neuro.2008.02.014  1
2008 Willis LM, Small BJ, Bickford PC, Umphlet CD, Moore AB, Granholm AC. Dietary blueberry supplementation affects growth but not vascularization of neural transplants. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 28: 1150-64. PMID 18285804 DOI: 10.1038/jcbfm.2008.3  1
2008 Bimonte-Nelson HA, Granholm AC, Nelson ME, Moore AB. Patterns of neurotrophin protein levels in male and female Fischer 344 rats from adulthood to senescence: how young is "young" and how old is "old"? Experimental Aging Research. 34: 13-26. PMID 18189165 DOI: 10.1080/03610730701761908  1
2008 Huang P, Woolson RF, Granholm AC. The use of a global statistical approach for the design and data analysis of clinical trials with multiple primary outcomes Experimental Stroke. 100-108. DOI: 10.2174/978160805001710901010100  1
2007 Boger HA, Middaugh LD, Patrick KS, Ramamoorthy S, Denehy ED, Zhu H, Pacchioni AM, Granholm AC, McGinty JF. Long-term consequences of methamphetamine exposure in young adults are exacerbated in glial cell line-derived neurotrophic factor heterozygous mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 8816-25. PMID 17699663 DOI: 10.1523/Jneurosci.1067-07.2007  1
2007 Naar JP, Flewelling LJ, Lenzi A, Abbott JP, Granholm A, Jacocks HM, Gannon D, Henry M, Pierce R, Baden DG, Wolny J, Landsberg JH. Brevetoxins, like ciguatoxins, are potent ichthyotoxic neurotoxins that accumulate in fish Toxicon. 50: 707-723. PMID 17675204 DOI: 10.1016/J.Toxicon.2007.06.005  1
2007 French KL, Bimonte-Nelson HA, Granholm AC. Galantamine effects on memory, spatial cue utilization, and neurotrophic factors in aged female rats. Cell Transplantation. 16: 197-205. PMID 17503733 DOI: 10.3727/000000007783464759  1
2007 Paredes D, Granholm AC, Bickford PC. Effects of NGF and BDNF on baseline glutamate and dopamine release in the hippocampal formation of the adult rat. Brain Research. 1141: 56-64. PMID 17292337 DOI: 10.1016/j.brainres.2007.01.018  1
2007 af Bjerkén S, Boger HA, Nelson M, Hoffer BJ, Granholm AC, Strömberg I. Effects of glial cell line-derived neurotrophic factor deletion on ventral mesencephalic organotypic tissue cultures. Brain Research. 1133: 10-9. PMID 17184739 DOI: 10.1016/j.brainres.2006.11.052  1
2007 Williams B, Granholm AC, Sambamurti K. Age-dependent loss of NGF signaling in the rat basal forebrain is due to disrupted MAPK activation. Neuroscience Letters. 413: 110-4. PMID 17182181 DOI: 10.1016/J.Neulet.2006.11.040  1
2007 Granholm AC. NGF-Producing Cell Transplants for Alzheimer's Disease Cellular Transplantation. 373-384. DOI: 10.1016/B978-012369415-7/50022-3  1
2006 Williams BJ, Eriksdotter-Jonhagen M, Granholm AC. Nerve growth factor in treatment and pathogenesis of Alzheimer's disease. Progress in Neurobiology. 80: 114-28. PMID 17084014 DOI: 10.1016/j.pneurobio.2006.09.001  1
2006 Boger HA, Middaugh LD, Huang P, Zaman V, Smith AC, Hoffer BJ, Tomac AC, Granholm AC. A partial GDNF depletion leads to earlier age-related deterioration of motor function and tyrosine hydroxylase expression in the substantia nigra. Experimental Neurology. 202: 336-47. PMID 16889771 DOI: 10.1016/J.Expneurol.2006.06.006  1
2006 Bimonte-Nelson HA, Francis KR, Umphlet CD, Granholm AC. Progesterone reverses the spatial memory enhancements initiated by tonic and cyclic oestrogen therapy in middle-aged ovariectomized female rats. The European Journal of Neuroscience. 24: 229-42. PMID 16882019 DOI: 10.1111/j.1460-9568.2006.04867.x  1
2006 Quintero EM, Willis L, Singleton R, Harris N, Huang P, Bhat N, Granholm AC. Behavioral and morphological effects of minocycline in the 6-hydroxydopamine rat model of Parkinson's disease. Brain Research. 1093: 198-207. PMID 16712819 DOI: 10.1016/j.brainres.2006.03.104  1
2006 French KL, Granholm AC, Moore AB, Nelson ME, Bimonte-Nelson HA. Chronic nicotine improves working and reference memory performance and reduces hippocampal NGF in aged female rats. Behavioural Brain Research. 169: 256-62. PMID 16488025 DOI: 10.1016/j.bbr.2006.01.008  1
2006 Griffin WC, Boger HA, Granholm AC, Middaugh LD. Partial deletion of glial cell line-derived neurotrophic factor (GDNF) in mice: Effects on sucrose reward and striatal GDNF concentrations. Brain Research. 1068: 257-60. PMID 16364262 DOI: 10.1016/J.Brainres.2005.10.080  1
2005 Granholm AC, Bachman D, Mintzer J, Sambamurti K. Commentary: "Ceramide and cholesterol: possible connections between normal aging of the brain and Alzheimer's disease. Just hypotheses or molecular pathways to be identified?" by Claudio Costantini, Rekha M.K. Kolasani, Luigi Puglielli. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 1: 53-4. PMID 19595818 DOI: 10.1016/J.Jalz.2005.06.010  1
2005 Williams B, Nelson M, Granholm AC, Coultrap S, Browning M, Curtis M. Altered NGF response but not release in the aged septo-hippocampal cholinergic system. Experimental Neurology. 196: 30-40. PMID 16137678 DOI: 10.1016/J.Expneurol.2005.07.001  1
2005 Willis L, Bickford P, Zaman V, Moore A, Granholm AC. Blueberry extract enhances survival of intraocular hippocampal transplants. Cell Transplantation. 14: 213-23. PMID 15929556 DOI: 10.3727/000000005783983142  1
2005 Willis L, Quintero EM, Nelson M, Granholm ACh. Regulation of trophic factor expression by innervating target regions in intraocular double transplants. Cell Transplantation. 14: 21-9. PMID 15789659  1
2004 Bimonte-Nelson HA, Nelson ME, Granholm AC. Progesterone counteracts estrogen-induced increases in neurotrophins in the aged female rat brain. Neuroreport. 15: 2659-63. PMID 15570173 DOI: 10.1097/00001756-200412030-00021  1
2004 Hunter CL, Bachman D, Granholm AC. Minocycline prevents cholinergic loss in a mouse model of Down's syndrome. Annals of Neurology. 56: 675-88. PMID 15468085 DOI: 10.1002/ana.20250  1
2004 Bimonte-Nelson HA, Singleton RS, Williams BJ, Granholm AC. Ovarian hormones and cognition in the aged female rat: II. progesterone supplementation reverses the cognitive enhancing effects of ovariectomy. Behavioral Neuroscience. 118: 707-14. PMID 15301598 DOI: 10.1037/0735-7044.118.4.707  1
2004 Sambamurti K, Granholm AC, Kindy MS, Bhat NR, Greig NH, Lahiri DK, Mintzer JE. Cholesterol and Alzheimer's disease: clinical and experimental models suggest interactions of different genetic, dietary and environmental risk factors. Current Drug Targets. 5: 517-28. PMID 15270198 DOI: 10.2174/1389450043345335  1
2004 Hunter CL, Quintero EM, Gilstrap L, Bhat NR, Granholm AC. Minocycline protects basal forebrain cholinergic neurons from mu p75-saporin immunotoxic lesioning. The European Journal of Neuroscience. 19: 3305-16. PMID 15217386 DOI: 10.1111/j.0953-816X.2004.03439.x  1
2004 Hunter CL, Bimonte-Nelson HA, Nelson M, Eckman CB, Granholm AC. Behavioral and neurobiological markers of Alzheimer's disease in Ts65Dn mice: effects of estrogen. Neurobiology of Aging. 25: 873-84. PMID 15212841 DOI: 10.1016/j.neurobiolaging.2003.10.010  1
2004 Quintero EM, Willis LM, Zaman V, Lee J, Boger HA, Tomac A, Hoffer BJ, Strömberg I, Granholm AC. Glial cell line-derived neurotrophic factor is essential for neuronal survival in the locus coeruleus-hippocampal noradrenergic pathway. Neuroscience. 124: 137-46. PMID 14960346 DOI: 10.1016/j.neuroscience.2003.11.001  1
2003 Granholm AC, Sanders L, Seo H, Lin L, Ford K, Isacson O. Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome. Hippocampus. 13: 905-14. PMID 14750653 DOI: 10.1002/hipo.10130  1
2003 Bimonte-Nelson HA, Singleton RS, Hunter CL, Price KL, Moore AB, Granholm AC. Ovarian hormones and cognition in the aged female rat: I. Long-term, but not short-term, ovariectomy enhances spatial performance. Behavioral Neuroscience. 117: 1395-406. PMID 14674857 DOI: 10.1037/0735-7044.117.6.1395  1
2003 Veng LM, Granholm AC, Rose GM. Age-related sex differences in spatial learning and basal forebrain cholinergic neurons in F344 rats. Physiology & Behavior. 80: 27-36. PMID 14568305 DOI: 10.1016/S0031-9384(03)00219-1  1
2003 Zaman V, Li Z, Middaugh L, Ramamoorthy S, Rohrer B, Nelson ME, Tomac AC, Hoffer BJ, Gerhardt GA, Granholm ACh. The noradrenergic system of aged GDNF heterozygous mice. Cell Transplantation. 12: 291-303. PMID 12797383  1
2003 Bimonte-Nelson HA, Singleton RS, Nelson ME, Eckman CB, Barber J, Scott TY, Granholm AC. Testosterone, but not nonaromatizable dihydrotestosterone, improves working memory and alters nerve growth factor levels in aged male rats. Experimental Neurology. 181: 301-12. PMID 12782002 DOI: 10.1016/S0014-4886(03)00061-X  1
2003 Hunter CL, Isacson O, Nelson M, Bimonte-Nelson H, Seo H, Lin L, Ford K, Kindy MS, Granholm AC. Regional alterations in amyloid precursor protein and nerve growth factor across age in a mouse model of Down's syndrome. Neuroscience Research. 45: 437-45. PMID 12657457 DOI: 10.1016/S0168-0102(03)00005-1  1
2003 Albeck D, Mesches MH, Juthberg S, Browning M, Bickford PC, Rose GM, Granholm AC. Exogenous NGF restores endogenous NGF distribution in the brain of the cognitively impaired aged rat. Brain Research. 967: 306-10. PMID 12650994 DOI: 10.1016/S0006-8993(03)02272-8  1
2003 Bimonte-Nelson HA, Hunter CL, Nelson ME, Granholm AC. Frontal cortex BDNF levels correlate with working memory in an animal model of Down syndrome. Behavioural Brain Research. 139: 47-57. PMID 12642175 DOI: 10.1016/S0166-4328(02)00082-7  1
2003 Hunter CL, Bimonte HA, Granholm AC. Behavioral comparison of 4 and 6 month-old Ts65Dn mice: age-related impairments in working and reference memory. Behavioural Brain Research. 138: 121-31. PMID 12527443 DOI: 10.1016/S0166-4328(02)00275-9  1
2003 Bimonte HA, Nelson ME, Granholm AC. Age-related deficits as working memory load increases: relationships with growth factors. Neurobiology of Aging. 24: 37-48. PMID 12493549 DOI: 10.1016/S0197-4580(02)00015-5  1
2002 Granholm AC, Ford KA, Hyde LA, Bimonte HA, Hunter CL, Nelson M, Albeck D, Sanders LA, Mufson EJ, Crnic LS. Estrogen restores cognition and cholinergic phenotype in an animal model of Down syndrome. Physiology & Behavior. 77: 371-85. PMID 12419414 DOI: 10.1016/S0031-9384(02)00884-3  1
2002 Bimonte HA, Granholm AC, Seo H, Isacson O. Spatial memory testing decreases hippocampal amyloid precursor protein in young, but not aged, female rats. Neuroscience Letters. 328: 50-4. PMID 12123857 DOI: 10.1016/S0304-3940(02)00442-1  1
2002 Pham TM, Winblad B, Granholm AC, Mohammed AH. Environmental influences on brain neurotrophins in rats. Pharmacology, Biochemistry, and Behavior. 73: 167-75. PMID 12076736 DOI: 10.1016/S0091-3057(02)00783-9  1
2002 McGrath J, Lintz E, Hoffer BJ, Gerhardt GA, Quintero EM, Granholm AC. Adeno-associated viral delivery of GDNF promotes recovery of dopaminergic phenotype following a unilateral 6-hydroxydopamine lesion. Cell Transplantation. 11: 215-27. PMID 12075987 DOI: 10.3727/096020198389988  1
2002 Isacson O, Seo H, Lin L, Albeck D, Granholm AC. Alzheimer's disease and Down's syndrome: roles of APP, trophic factors and ACh. Trends in Neurosciences. 25: 79-84. PMID 11814559 DOI: 10.1016/S0166-2236(02)02037-4  1
2001 Bickford PC, Bowenkamp K, Taglialatela G, Hoertig G, Granholm AC. GDNF improves cerebellar Purkinje neuron function in aged F344 rats. Microscopy Research and Technique. 54: 309-16. PMID 11514987 DOI: 10.1002/Jemt.1143  1
2001 Granholm AC, Helt C, Srivastava N, Backman C, Gerhardt GA. Effects of age and GDNF on noradrenergic innervation of the hippocampal formation: studies from intraocular grafts. Microscopy Research and Technique. 54: 298-308. PMID 11514986 DOI: 10.1002/jemt.1142  1
2001 Helt CE, Hoernig GR, Albeck DS, Gerhardt GA, Ickes B, Reyland ME, Quissell DO, Strömberg I, Granholm AC. Neuroprotection of grafted neurons with a GDNF/caspase inhibitor cocktail. Experimental Neurology. 170: 258-69. PMID 11476591 DOI: 10.1006/Exnr.2001.7709  1
2001 Palmer MR, Granholm AC, van Horne CG, Giardina KE, Freund RK, Moorhead JW, Gerhardt GA. Intranigral transplantation of solid tissue ventral mesencephalon or striatal grafts induces behavioral recovery in 6-OHDA-lesioned rats. Brain Research. 890: 86-99. PMID 11164771 DOI: 10.1016/S0006-8993(00)03084-5  1
2001 Granholm AC, Strömberg I. Introduction: Factors influencing neurite outgrowth and regeneration Microscopy Research and Technique. 54: 271-272. DOI: 10.1002/jemt.1139  1
2000 Granholm AC. Oestrogen and nerve growth factor - neuroprotection and repair in Alzheimer's disease. Expert Opinion On Investigational Drugs. 9: 685-94. PMID 11060702 DOI: 10.1517/13543784.9.4.685  1
2000 Zuch CL, Nordstroem VK, Briedrick LA, Hoernig GR, Granholm AC, Bickford PC. Time course of degenerative alterations in nigral dopaminergic neurons following a 6-hydroxydopamine lesion. The Journal of Comparative Neurology. 427: 440-54. PMID 11054705 DOI: 10.1002/1096-9861(20001120)427:3<440::AID-CNE10>3.0.CO;2-7  1
2000 Ickes BR, Pham TM, Sanders LA, Albeck DS, Mohammed AH, Granholm AC. Long-term environmental enrichment leads to regional increases in neurotrophin levels in rat brain. Experimental Neurology. 164: 45-52. PMID 10877914 DOI: 10.1006/exnr.2000.7415  1
2000 Granholm AC, Reyland M, Albeck D, Sanders L, Gerhardt G, Hoernig G, Shen L, Westphal H, Hoffer B. Glial cell line-derived neurotrophic factor is essential for postnatal survival of midbrain dopamine neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 3182-90. PMID 10777782 DOI: 10.1523/Jneurosci.20-09-03182.2000  1
2000 Granholm AC, Sanders LA, Crnic LS. Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndrome. Experimental Neurology. 161: 647-63. PMID 10686084 DOI: 10.1006/exnr.1999.7289  1
1999 Granholm AC, Emerich D. Fifth Annual Meeting of the American Society for Neural Transplantation and Repair. Cell Transplantation. 8: 7-9. PMID 28153075 DOI: 10.1177/096368979900800110  0.01
1999 Pham TM, Ickes B, Albeck D, Söderström S, Granholm AC, Mohammed AH. Changes in brain nerve growth factor levels and nerve growth factor receptors in rats exposed to environmental enrichment for one year. Neuroscience. 94: 279-86. PMID 10613518 DOI: 10.1016/S0306-4522(99)00316-4  1
1999 Henry S, Pfenninger KH, Mott JL, Granholm AC. Anatomical distribution of glycoprotein 93 (gp93) on nerve fibers during rat brain development. Cell and Tissue Research. 297: 67-79. PMID 10398884 DOI: 10.1007/S004410051334  1
1999 Albeck DS, Bäckman C, Veng L, Friden P, Rose GM, Granholm A. Acute application of NGF increases the firing rate of aged rat basal forebrain neurons. The European Journal of Neuroscience. 11: 2291-304. PMID 10383618 DOI: 10.1046/j.1460-9568.1999.00644.x  1
1999 Granholm AC, Sanders LA, Ickes B, Albeck D, Hoffer BJ, Young DA, Kaplan PL. Effects of osteogenic protein-1 (OP-1) treatment on fetal spinal cord transplants to the anterior chamber of the eye. Cell Transplantation. 8: 75-85. PMID 10338277  1
1999 Granholm AC. Fifth Annual Meeting of the American Society for Neural Transplantation and Repair: Introduction Cell Transplantation. 8: 7-9.  1
1998 Nagy JI, Price ML, Staines WA, Lynn BD, Granholm AC. The hyaluronan receptor RHAMM in noradrenergic fibers contributes to axon growth capacity of locus coeruleus neurons in an intraocular transplant model. Neuroscience. 86: 241-55. PMID 9692758 DOI: 10.1016/S0306-4522(98)00017-7  1
1998 Granholm AC, Albeck D, Bäckman C, Curtis M, Ebendal T, Friden P, Henry M, Hoffer B, Kordower J, Rose GM, Söderström S, Bartus RT. A non-invasive system for delivering neural growth factors across the blood-brain barrier: a review. Reviews in the Neurosciences. 9: 31-55. PMID 9683326 DOI: 10.1515/Revneuro.1998.9.1.31  1
1998 Granholm AC, Henry S, Herbert MA, Eken S, Gerhardt GA, van Horne C. Kidney cografts enhance fiber outgrowth from ventral mesencephalic grafts to the 6-OHDA-lesioned striatum, and improve behavioral recovery. Cell Transplantation. 7: 197-212. PMID 9588601 DOI: 10.1016/S0963-6897(97)00168-1  1
1997 Bäckman C, Rose GM, Bartus RT, Hoffer BJ, Mufson EJ, Granholm AC. Carrier mediated delivery of NGF: alterations in basal forebrain neurons in aged rats revealed using antibodies against low and high affinity NGF receptors. The Journal of Comparative Neurology. 387: 1-11. PMID 9331167 DOI: 10.1002/(Sici)1096-9861(19971013)387:1<1::Aid-Cne1>3.0.Co;2-5  1
1997 Granholm AC, Mott JL, Bowenkamp K, Eken S, Henry S, Hoffer BJ, Lapchak PA, Palmer MR, van Horne C, Gerhardt GA. Glial cell line-derived neurotrophic factor improves survival of ventral mesencephalic grafts to the 6-hydroxydopamine lesioned striatum. Experimental Brain Research. 116: 29-38. PMID 9305812 DOI: 10.1007/Pl00005741  1
1997 Albeck DS, Hoffer BJ, Quissell D, Sanders LA, Zerbe G, Granholm AC. A non-invasive transport system for GDNF across the blood-brain barrier. Neuroreport. 8: 2293-8. PMID 9243628 DOI: 10.1097/00001756-199707070-00039  1
1997 Srivastava N, Granholm AC, Gerhardt GA. Collateral sprouting of central noradrenergic neurons during aging: histochemical and neurochemical studies in intraocular triple transplants. Experimental Neurology. 145: 524-35. PMID 9217088 DOI: 10.1006/exnr.1997.6485  1
1997 Granholm AC, Srivastava N, Mott JL, Henry S, Henry M, Westphal H, Pichel JG, Shen L, Hoffer BJ. Morphological alterations in the peripheral and central nervous systems of mice lacking glial cell line-derived neurotrophic factor (GDNF): immunohistochemical studies. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 1168-78. PMID 8994069  1
1997 Curtis M, Granholm AC, Mufson EJ, Bartus RT. Administration of an anti-transferrin receptor antibody-NGF conjugate causes upregulation of trkA immunoreactivity in brain Faseb Journal. 11: A430.  1
1996 Pichel JG, Shen L, Sheng HZ, Granholm AC, Drago J, Grinberg A, Lee EJ, Huang SP, Saarma M, Hoffer BJ, Sariola H, Westphal H. GDNF is required for kidney development and enteric innervation. Cold Spring Harbor Symposia On Quantitative Biology. 61: 445-57. PMID 9246473  1
1996 Bowenkamp KE, David D, Lapchak PL, Henry MA, Granholm AC, Hoffer BJ, Mahalik TJ. 6-hydroxydopamine induces the loss of the dopaminergic phenotype in substantia nigra neurons of the rat. A possible mechanism for restoration of the nigrostriatal circuit mediated by glial cell line-derived neurotrophic factor. Experimental Brain Research. 111: 1-7. PMID 8891630 DOI: 10.1007/BF00229549  1
1996 Price ML, Hoffer BJ, Granholm AC. Effects of GDNF on fetal septal forebrain transplants in oculo. Experimental Neurology. 141: 181-9. PMID 8812151 DOI: 10.1006/exnr.1996.0152  1
1996 Bäckman C, Rose GM, Hoffer BJ, Henry MA, Bartus RT, Friden P, Granholm AC. Systemic administration of a nerve growth factor conjugate reverses age-related cognitive dysfunction and prevents cholinergic neuron atrophy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 5437-42. PMID 8757256 DOI: 10.1523/Jneurosci.16-17-05437.1996  1
1996 Granholm AC, Curtis M, Diamond DM, Branch BJ, Heman KL, Rose GM. Development of an intact blood-brain barrier in brain tissue transplants is dependent on the site of transplantation. Cell Transplantation. 5: 305-14. PMID 8689041 DOI: 10.1016/0963-6897(95)02037-3  1
1996 Granholm AC. Second annual meeting of the American Society for Neural Transplantation. Cell Transplantation. 5: 127-30. PMID 8689026 DOI: 10.1016/S0963-6897(96)90023-8  1
1996 Pichel JG, Shen L, Sheng HZ, Granholm AC, Drago J, Grinberg A, Lee EJ, Huang SP, Saarma M, Hoffer BJ, Sariola H, Westphal H. Defects in enteric innervation and kidney development in mice lacking GDNF. Nature. 382: 73-6. PMID 8657307 DOI: 10.1038/382073a0  1
1995 Curtis M, Bergman H, Price ML, Srivastava N, Granholm AC. Hypothalamic tissue stimulates hippocampal pyramidal neuron survival during development: evidence from intraocular double transplants. Hippocampus. 5: 584-94. PMID 8646284 DOI: 10.1002/hipo.450050609  0.64
1995 Granholm AC, Price ML, Owen MD. Tyrosine hydroxylase in the cerebral ganglia of the American cockroach (Periplaneta americana L.): an immunohistochemical study. Cell and Tissue Research. 282: 49-57. PMID 8581926 DOI: 10.1007/BF00319132  1
1995 Granholm AC, Bergman H, Dudek E, Browning M. Synapsin I in intraocular hippocampal transplants during maturation and aging: effects of brainstem cografts. Cell Transplantation. 4: 3-12. PMID 7728331 DOI: 10.1016/0963-6897(94)E0011-7  1
1995 Bäckman C, Biddle PT, Ebendal T, Friden PM, Gerhardt GA, Henry MA, Mackerlova L, Söderström S, Strömberg I, Walus L. Effects of transferrin receptor antibody-NGF conjugate on young and aged septal transplants in oculo. Experimental Neurology. 132: 1-15. PMID 7720818 DOI: 10.1016/0014-4886(95)90037-3  1
1995 Hudson J, Granholm AC, Gerhardt GA, Henry MA, Hoffman A, Biddle P, Leela NS, Mackerlova L, Lile JD, Collins F. Glial cell line-derived neurotrophic factor augments midbrain dopaminergic circuits in vivo. Brain Research Bulletin. 36: 425-32. PMID 7712205 DOI: 10.1016/0361-9230(94)00224-O  1
1995 Bergman H, Nagy JI, Granholm AC. Intracranial transplantation and survival of tuberomammillary histaminergic neurons. Neuroscience. 64: 61-70. PMID 7708215 DOI: 10.1016/0306-4522(94)00371-B  1
1995 Bowenkamp KE, Hoffman AF, Gerhardt GA, Henry MA, Biddle PT, Hoffer BJ, Granholm AC. Glial cell line-derived neurotrophic factor supports survival of injured midbrain dopaminergic neurons. The Journal of Comparative Neurology. 355: 479-89. PMID 7636027 DOI: 10.1002/Cne.903550402  1
1995 Bergman H, Prell GD, Lupica CR, Granholm AC. Characterization of histaminergic H3 receptors in intraocular tuberomammillary transplants containing histaminergic neurons. Experimental Neurology. 136: 12-21. PMID 7589330 DOI: 10.1006/Exnr.1995.1079  1
1994 Granholm AC, Bäckman C, Bloom F, Ebendal T, Gerhardt GA, Hoffer B, Mackerlova L, Olson L, Söderström S, Walus LR. NGF and anti-transferrin receptor antibody conjugate: short and long-term effects on survival of cholinergic neurons in intraocular septal transplants. The Journal of Pharmacology and Experimental Therapeutics. 268: 448-59. PMID 8301587  1
1994 Freedman R, Strömberg I, Nordström AL, Seiger A, Olson L, Bygdeman M, Wiesel FA, Granholm AC, Hoffer BJ. Neuronal development in embryonic brain tissue derived from schizophrenic women and grafted to animal hosts. Schizophrenia Research. 13: 259-70. PMID 7841140 DOI: 10.1016/0920-9964(94)90051-5  1
1994 Granholm A, Biddle PT, Bäckman C, Ebendal T, Gerhardt G, Hoffer B, Mackerlova L, Olson L, Söderström S, Walus L, Friden P. Peripheral Administration of Nerve Growth Factor Conjugated to an Anti-transferrin Receptor Antibody Increases Cholinergic Neuron Survival in Intraocular Forebrain Transplants Methods in Neurosciences. 21: 71-92. DOI: 10.1016/B978-0-12-185291-7.50011-4  1
1993 Friden PM, Walus LR, Watson P, Doctrow SR, Kozarich JW, Bäckman C, Bergman H, Hoffer B, Bloom F, Granholm AC. Blood-brain barrier penetration and in vivo activity of an NGF conjugate. Science (New York, N.Y.). 259: 373-7. PMID 8420006 DOI: 10.1126/Science.8420006  1
1993 Kordower JH, Mufson EJ, Granholm AC, Hoffer B, Friden PM. Delivery of trophic factors to the primate brain. Experimental Neurology. 124: 21-30. PMID 8282075 DOI: 10.1006/Exnr.1993.1169  1
1992 Palmer MR, Granholm AC. Electrophysiological effects of ethanol on hippocampal and cerebellar neurons cografted with locus coeruleus in oculo: role of the noradrenergic circuitry. The Journal of Pharmacology and Experimental Therapeutics. 260: 887-95. PMID 1738130  1
1992 Backman C, Granholm AC. Effects of ethanol on development of dorsal raphe transplants in oculo: a morphological and electrophysiological study. The Journal of Comparative Neurology. 320: 136-44. PMID 1401240 DOI: 10.1002/cne.903200110  1
1992 Granholm AC, Gerhardt GA, Bygdeman M, Strömberg I. Human fetal xenografts of brainstem tissue containing locus coeruleus neurons: functional and structural studies of intraocular grafts in athymic nude rats. Experimental Neurology. 118: 7-17. PMID 1397178 DOI: 10.1016/0014-4886(92)90017-K  1
1992 Hall M, Wang Y, Granholm AC, Stevens JO, Young D, Hoffer BJ. Comparison of fetal rabbit brain xenografts to three different strains of athymic nude rats: electrophysiological and immunohistochemical studies of intraocular grafts. Cell Transplantation. 1: 71-82. PMID 1344293  1
1992 Bergman H, Browning M, Granholm AC. Development of synapsin I and synapsin II in intraocular hippocampal transplants. Hippocampus. 2: 339-47. PMID 1308193 DOI: 10.1002/Hipo.450020402  1
1991 Gerhardt GA, Palmer MR, Granholm AC. Age-induced changes in single locus coeruleus brain transplants grown in oculo: an in vivo electrochemical study. Neurobiology of Aging. 12: 487-94. PMID 1685219 DOI: 10.1016/0197-4580(91)90078-X  1
1990 Granholm AC. Long-term effects of thyroid hormone deficiency on noradrenergic circuitry: electrophysiological changes in intraocular hippocampus-locus coeruleus double transplants. Restorative Neurology and Neuroscience. 1: 331-8. PMID 21551575 DOI: 10.3233/RNN-1990-1504  0.01
1990 Palmer MR, Eriksdotter-Nilsson M, Bygdeman M, Stieg P, Strömberg I, Olson L, Seiger A, Hoffer BJ, Granholm AC. Electrophysiologic effects of ethanol in human brain xenografts in oculo: antagonism by Ro15-4513. The Journal of Pharmacology and Experimental Therapeutics. 254: 1100-6. PMID 2395107  1
1990 Wassef M, Sotelo C, Thomasset M, Granholm AC, Leclerc N, Rafrafi J, Hawkes R. Expression of compartmentation antigen zebrin I in cerebellar transplants. The Journal of Comparative Neurology. 294: 223-34. PMID 2332530 DOI: 10.1002/Cne.902940207  1
1990 Granholm AC, Bergman H, Mackerlova L, Blomqvist A. Intraocular hypothalamic transplants containing histaminergic neurons: innervation of host iris and hippocampal cografts. Experimental Neurology. 108: 189-97. PMID 1693577 DOI: 10.1016/0014-4886(90)90123-A  1
1989 Granholm AC, Eriksdotter-Nilsson M, Strömberg I, Stieg P, Seiger A, Bygdeman M, Geffard M, Oertel W, Dahl D, Olson L. Morphological and electrophysiological studies of human hippocampal transplants in the anterior eye chamber of athymic nude rats. Experimental Neurology. 104: 162-71. PMID 2707363 DOI: 10.1016/S0014-4886(89)80010-X  1
1989 Mahalik TJ, Strömberg I, Gerhardt GA, Granholm AC, Seiger A, Bygdeman M, Olson L, Hoffer BJ, Finger TE. Human ventral mesencephalic xenografts to the catecholamine-depleted striata of athymic rats: ultrastructure and immunocytochemistry. Synapse (New York, N.Y.). 4: 19-29. PMID 2570467 DOI: 10.1002/syn.890040104  1
1989 Eriksdotter-Nilsson M, Gerhardt G, Seiger A, Olson L, Hoffer B, Granholm AC. Age-related alterations in noradrenergic input to the hippocampal formation: structural and functional studies in intraocular transplants. Brain Research. 478: 269-80. PMID 2564300 DOI: 10.1016/0006-8993(89)91507-2  1
1989 Strömberg I, Almqvist P, Bygdeman M, Finger TE, Gerhardt G, Granholm AC, Mahalik TJ, Seiger A, Olson L, Hoffer B. Human fetal mesencephalic tissue grafted to dopamine-denervated striatum of athymic rats: light- and electron-microscopical histochemistry and in vivo chronoamperometric studies. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 9: 614-24. PMID 2563765 DOI: 10.1523/Jneurosci.09-02-00614.1989  1
1989 Eriksdotter-Nilsson M, Gerhardt G, Seiger A, Hoffer B, Granholm AC. Multiple changes in noradrenergic mechanisms in the coeruleo-hippocampal pathway during aging. Structural and functional correlates in intraocular double grafts. Neurobiology of Aging. 10: 117-24. PMID 2542818 DOI: 10.1016/0197-4580(89)90020-1  1
1988 Hoffer BJ, Granholm AC, Stevens JO, Olson L. Catecholamine-containing grafts in parkinsonism: past and present. Clinical Research. 36: 189-95. PMID 3286096  1
1988 Hoffer B, Bickford-Wimer P, Bygdeman M, Granholm AC, Olson L, Seiger A, Stevens J, Strömberg I. Electrophysiological studies of human cerebral and cerebellar cortical tissue grafted to the anterior eye chamber of athymic rodents. Progress in Brain Research. 78: 591-7. PMID 3247454 DOI: 10.1016/S0079-6123(08)60335-0  1
1988 Bickford-Wimer PC, Granholm AC, Gerhardt GA. Cerebellar noradrenergic systems in aging: studies in situ and in in oculo grafts. Neurobiology of Aging. 9: 591-9. PMID 3211262 DOI: 10.1016/S0197-4580(88)80118-0  1
1988 Granholm AC, Gerhardt GA, Moore E, Eriksdotter-Nilsson M, Nylén P, Johnson AC, Henschen A, Shirley MA, Palmer MR, Hoffer BJ. Toluene exposure during maturation of intraocular brain tissue transplants: alterations of host and graft cerebellar Purkinje neuron function and sensitivity to norepinephrine. Toxicology and Applied Pharmacology. 96: 296-304. PMID 3194916 DOI: 10.1016/0041-008X(88)90088-9  1
1988 Strömberg I, Almqvist P, Bygdeman M, Finger TE, Gerhardt G, Granholm AC, Mahalik TJ, Seiger A, Hoffer B, Olson L. Intracerebral xenografts of human mesencephalic tissue into athymic rats: immunochemical and in vivo electrochemical studies. Proceedings of the National Academy of Sciences of the United States of America. 85: 8331-4. PMID 3186728 DOI: 10.1073/Pnas.85.21.8331  0.88
1988 Granholm AC, Palmer MR. Electrophysiological effects of norepinephrine on Purkinje neurons in intraocular cerebellar grafts: alpha- vs beta-specificity. Brain Research. 459: 256-64. PMID 3179706 DOI: 10.1016/0006-8993(88)90641-5  1
1987 Granholm AC, Gerhardt GA, Eriksdotter-Nilsson M, Bickford-Wimer PC, Palmer MR, Seiger A, Olson L, Hoffer BJ. Age-related changes in cerebellar noradrenergic pre- and postsynaptic mechanisms: intrinsic vs extrinsic determinants evaluated with brain grafts in oculo. Brain Research. 423: 71-8. PMID 3676821 DOI: 10.1016/0006-8993(87)90826-2  1
1987 Hall ME, Granholm AC, Stevens JO, Hoffer BJ. Myocardium and cortex cerebri xenografts transplanted into the anterior chamber of the eye of athymic rats: a morphologic and electrophysiologic profile. Neuroscience Letters. 75: 89-94. PMID 3554011 DOI: 10.1016/0304-3940(87)90081-4  1
1987 Bickford-Wimer P, Granholm AC, Bygdeman M, Hoffer B, Olson L, Seiger A, Strömberg I. Human fetal cerebellar and cortical tissue transplanted to the anterior eye chamber of athymic rats: electrophysiological and structural studies. Proceedings of the National Academy of Sciences of the United States of America. 84: 5957-61. PMID 3475712 DOI: 10.1073/PNAS.84.16.5957  1
1987 Olson L, Strömberg I, Bygdeman M, Granholm AC, Hoffer B, Freedman R, Seiger A. Human fetal tissues grafted to rodent hosts: structural and functional observations of brain, adrenal and heart tissues in oculo. Experimental Brain Research. 67: 163-78. PMID 3305059 DOI: 10.1007/Bf00269464  1
1986 Johansson AS, Isacsson G, Isberg A, Granholm AC. Distribution of substance P-like immunoreactive nerve fibers in temporomandibular joint soft tissues of monkey. Scandinavian Journal of Dental Research. 94: 225-32. PMID 3461542  1
1986 Granholm AC, Almqvist P, Seiger A, Olson L. Thy-1-like immunoreactivity in human brain during development. Brain Research Bulletin. 17: 107-15. PMID 2875772 DOI: 10.1016/0361-9230(86)90166-8  1
1986 Seiger A, Almqvist P, Granholm AC, Olson L. On the localization of Thy-1-like immunoreactivity in the rodent and human nervous system. Medical Biology. 64: 109-17. PMID 2875228  1
1985 Granholm AC, Dahl D, Siegel RA, Björklund H, Seiger A. Delayed development of GFA immunoreactivity in the parietal cortex during thyroid hormone deficiency. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 3: 149-56. PMID 24874596 DOI: 10.1016/0736-5748(85)90005-X  1
1985 Granholm AC, Dahl D, Björklund H, Seiger A. Delayed development of GFA immunoreactivity in intraocular cortex cerebri grafts during thyroid hormone deficiency. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 3: 33-40. PMID 24874491 DOI: 10.1016/0736-5748(85)90017-6  1
1985 Granholm AC. Effects of thyroid hormone deficiency on glial constituents in developing cerebellum of the rat. Experimental Brain Research. 59: 451-6. PMID 3896833  0.01
1985 Granholm AC, Almqvist P, Seiger A, Olson L. Distribution of Thy-1-like immunoreactivity in normal, sympathetically denervated and grafted mouse irides. Histochemistry. 82: 107-11. PMID 2860083 DOI: 10.1007/BF00708193  1
1984 Granholm AC, Siegel RA, Seiger A. Thyroid hormone dependency of the developing dorsal raphe nucleus but not the superior cervical ganglion. Evidence from intraocular grafting experiments. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 2: 337-45. PMID 24874144 DOI: 10.1016/0736-5748(84)90070-4  1
1984 Granholm AC. Histology, innervation and radiographic appearance of fetal rat tooth germs developing in oculo. Scandinavian Journal of Dental Research. 92: 381-90. PMID 6593803  1
1984 Granholm AC, Hall M, Palmer MR, Seiger A. Structural and functional impairment of adrenergic input to intraocular cerebellar grafts during thyroid hormone deficiency. Central Nervous System Trauma : Journal of the American Paralysis Association. 1: 105-15. PMID 6545679  1
1984 Ayer-Le Lievre CS, Granholm AC, Sieger A. Silver impregnation of intrinsic sensory innervation of rat iris in toto. Journal of Anatomy. 138: 309-21. PMID 6201470  0.01
1982 Granholm AC, Olson L, Seiger A. Intraocular development and adrenergic innervation of cortical and subcortical brain areas: influence of thyroid hormone deficiency. Developmental Neuroscience. 5: 436-46. PMID 7160309 DOI: 10.1159/000112704  1
1982 Seiger A, Granholm AC. Intraocular fibre growth of grafted locus coeruleus neurons: sensory denervation counteracts alterations induced by thyroid hormone deficiency. Medical Biology. 60: 159-64. PMID 7109718  1
1982 Mikoshiba K, Yokoyama M, Takamatsu K, Lysz TW, Alderson RF, Sze PY, Burrage TG, Lentz TL, Druse MJ, Unsicker K, Millar TJ, Hofmann H, Lauder JM, Zimmerman EF, Bulger JE, ... ... Granholm A, et al. Contents Vol. 5, 1982 Developmental Neuroscience. 5. DOI: 10.1159/000112720  1
1982 Mikoshiba K, Yokoyama M, Takamatsu K, Lysz TW, Alderson RF, Sze PY, Burrage TG, Lentz TL, Druse MJ, Unsicker K, Millar TJ, Hofmann H, Lauder JM, Zimmerman EF, Bulger JE, ... ... Granholm A, et al. Subject Index Vol. 5, 1982 Developmental Neuroscience. 5: 569-570. DOI: 10.1159/000112719  1
1981 Seiger A, Granholm AC. Thyroxin dependency of the developing locus coeruleus. Evidence from intraocular grafting experiments. Cell and Tissue Research. 220: 1-15. PMID 7273121  1
1981 Granholm AC, Seiger A. Thyroid hormone dependency in immature but not mature grafted locus coeruleus neurons. Evidence from intraocular innervation of iris transplants. Medical Biology. 59: 51-7. PMID 7266087  1
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