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Sudha Chakrapani - Publications

Affiliations: 
Case Western Reserve University, Cleveland Heights, OH, United States 
Website:
http://physiology.case.edu/media/faculty_cvs/Chakrapani_CV.pdf
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50 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Kumar A, Kindig K, Rao S, Zaki AM, Basak S, Sansom MSP, Biggin PC, Chakrapani S. Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs. Nature Communications. 13: 4862. PMID 35982060 DOI: 10.1038/s41467-022-32594-5  0.388
2021 Kumar A, Basak S, Chakrapani S. Recombinant expression and purification of pentameric ligand-gated ion channels for Cryo-EM structural studies. Methods in Enzymology. 652: 81-103. PMID 34059291 DOI: 10.1016/bs.mie.2021.01.022  0.453
2021 Gibbs E, Chakrapani S. Structure, Function and Physiology of 5-Hydroxytryptamine Receptors Subtype 3. Sub-Cellular Biochemistry. 96: 373-408. PMID 33252737 DOI: 10.1007/978-3-030-58971-4_11  0.318
2020 Basak S, Kumar A, Ramsey S, Gibbs E, Kapoor A, Filizola M, Chakrapani S. High-resolution structures of multiple 5-HTR-setron complexes reveal a novel mechanism of competitive inhibition. Elife. 9. PMID 33063666 DOI: 10.7554/eLife.57870  0.37
2020 Kumar A, Basak S, Rao S, Gicheru Y, Mayer ML, Sansom MSP, Chakrapani S. Mechanisms of activation and desensitization of full-length glycine receptor in lipid nanodiscs. Nature Communications. 11: 3752. PMID 32719334 DOI: 10.1038/S41467-020-17364-5  0.594
2020 Bean BP, Chakrapani S, Hibbs RE. Decision letter: Cryo-EM analysis of PIP2 regulation in mammalian GIRK channels Elife. DOI: 10.7554/Elife.60552.Sa1  0.503
2019 Basak S, Gicheru Y, Kapoor A, Mayer ML, Filizola M, Chakrapani S. Molecular mechanism of setron-mediated inhibition of full-length 5-HT receptor. Nature Communications. 10: 3225. PMID 31324772 DOI: 10.2210/Pdb6Np0/Pdb  0.305
2019 Chanda B, Chakrapani S. Decision letter: Structural and functional characterization of an otopetrin family proton channel Elife. DOI: 10.7554/Elife.46710.023  0.494
2018 Basak S, Gicheru Y, Rao S, Sansom MSP, Chakrapani S. Cryo-EM reveals two distinct serotonin-bound conformations of full-length 5-HT receptor. Nature. 563: 270-274. PMID 30401837 DOI: 10.2210/Pdb6Dg7/Pdb  0.431
2018 Gicheru Y, Chakrapani S. Direct visualization of ion-channel gating in a native environment. Proceedings of the National Academy of Sciences of the United States of America. 115: 10198-10200. PMID 30257939 DOI: 10.1073/pnas.1814277115  0.599
2018 Chatterjee S, Vyas R, Chalamalasetti SV, Sahu ID, Clatot J, Wan X, Lorigan GA, Deschênes I, Chakrapani S. The voltage-gated sodium channel pore exhibits conformational flexibility during slow inactivation. The Journal of General Physiology. PMID 30082431 DOI: 10.1085/Jgp.201812118  0.626
2018 Basak S, Gicheru Y, Samanta A, Molugu SK, Huang W, Fuente M, Hughes T, Taylor DJ, Nieman MT, Moiseenkova-Bell V, Chakrapani S. Cryo-EM structure of 5-HT3A receptor in its resting conformation. Nature Communications. 9: 514. PMID 29410406 DOI: 10.1038/s41467-018-02997-4  0.47
2018 Hughes TET, Lodowski DT, Huynh KW, Yazici A, Del Rosario J, Kapoor A, Basak S, Samanta A, Han X, Chakrapani S, Zhou ZH, Filizola M, Rohacs T, Han S, Moiseenkova-Bell VY. Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM. Nature Structural & Molecular Biology. 25: 53-60. PMID 29323279 DOI: 10.1038/S41594-017-0009-1  0.632
2018 Chatterjee S, Vyas R, Chalamalasetti S, Sahu ID, Clatot J, Lorigan GA, Deschenes I, Chakrapani S. Structural Dynamics of Slow-Inactivation in a Voltage-Gated Sodium Channel Biophysical Journal. 114: 38a-39a. DOI: 10.1016/J.Bpj.2017.11.262  0.606
2018 Hughes TE, Lodowski D, Huynh K, Yazici A, del Rosario J, Kapoor A, Basak S, Samanta A, Chakrapani S, Zhou ZH, Filizola M, Rohacs T, Han S, Moiseenkova-Bell V. Mechanism of TRPV5 Modulation and Gating as Revealed by Cryo-EM Biophysical Journal. 114: 396a. DOI: 10.1016/J.Bpj.2017.11.2193  0.421
2017 Basak S, Schmandt N, Gicheru Y, Chakrapani S. Crystal structure and dynamics of a lipid-induced potential desensitized-state of a pentameric ligand-gated channel. Elife. 6. PMID 28262093 DOI: 10.7554/eLife.23886  0.632
2017 Basak S, Schmandt N, Gicheru Y, Chakrapani S. Author response: Crystal structure and dynamics of a lipid-induced potential desensitized-state of a pentameric ligand-gated channel Elife. DOI: 10.7554/Elife.23886.033  0.52
2017 Gicheru YW, Basak S, Chakrapani S. Structural Mechanisms Underlying PUFA Modulation in Pentameric Ligand Gated Ion Channels Biophysical Journal. 112: 320a. DOI: 10.1016/J.BPJ.2016.11.1737  0.6
2016 Basak S, Chatterjee S, Chakrapani S. Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels. Journal of Visualized Experiments : Jove. PMID 27403967 DOI: 10.3791/54127  0.551
2016 Basak S, Schmandt N, Chakrapani S. Molecular Insights into Allosteric Modulation of GLIC Gating by Membrane Lipids Biophysical Journal. 110: 456a-457a. DOI: 10.1016/J.BPJ.2015.11.2446  0.579
2016 Chakrapani S. Mechanisms of Gating and Modulation in Pentameric Ligand Gated Channels Biophysical Journal. 110: 9a. DOI: 10.1016/J.BPJ.2015.11.100  0.574
2015 Schmandt N, Velisetty P, Chalamalasetti SV, Stein RA, Bonner R, Talley L, Parker MD, Mchaourab HS, Yee VC, Lodowski DT, Chakrapani S. A chimeric prokaryotic pentameric ligand-gated channel reveals distinct pathways of activation. The Journal of General Physiology. 146: 323-40. PMID 26415570 DOI: 10.1085/Jgp.201511478  0.667
2015 Chakrapani S. EPR Studies of Gating Mechanisms in Ion Channels. Methods in Enzymology. 557: 279-306. PMID 25950970 DOI: 10.1016/bs.mie.2014.12.030  0.622
2015 Schmandt N, Lodowski DT, Yee V, Chakrapani S. An ELIC-GLIC Chimera Reveals Distinct Pathways of Activation in the Cys-Loop Family of Receptors Biophysical Journal. 108: 192a. DOI: 10.1016/J.Bpj.2014.11.1060  0.606
2014 Huynh KW, Cohen MR, Chakrapani S, Holdaway HA, Stewart PL, Moiseenkova-Bell VY. Structural insight into the assembly of TRPV channels. Structure (London, England : 1993). 22: 260-8. PMID 24373766 DOI: 10.1016/j.str.2013.11.008  0.569
2014 Velisetty P, Chalamalasetti SV, Chakrapani S. Structural basis for allosteric coupling at the membrane-protein interface in Gloeobacter violaceus ligand-gated ion channel (GLIC). The Journal of Biological Chemistry. 289: 3013-25. PMID 24338475 DOI: 10.1074/jbc.M113.523050  0.584
2014 Velisetty P, Chalamalasetti SV, Chakrapani S. Structural Basis for Allosteric Coupling at the Membrane-Protein Interface in GLIC Biophysical Journal. 106: 641a-642a. DOI: 10.1016/J.BPJ.2013.11.3552  0.503
2013 Ostmeyer J, Chakrapani S, Pan AC, Perozo E, Roux B. Recovery from slow inactivation in K+ channels is controlled by water molecules. Nature. 501: 121-4. PMID 23892782 DOI: 10.1038/Nature12395  0.744
2013 Velisetty P, Chalamalasetti SV, Chakrapani S. Conformational Transitions Underlying Pore Opening and Desensitization in Membrane-Embedded GLIC Biophysical Journal. 104: 542a. DOI: 10.1016/J.BPJ.2012.11.3003  0.524
2013 Moiseenkova-Bell VY, Cvetkov TL, Wang L, Huynh KW, Fernandez-Ballester G, Chakrapani S, Ferrer-Montiel A, Chance MR. Structural Insights into the Dynamics of the TRPA1 Activation Mechanism Biophysical Journal. 104: 377a-378a. DOI: 10.1016/J.Bpj.2012.11.2103  0.642
2013 Ostmeyer JL, Chakrapani S, Perozo E, Roux B. Rate of Recovery from Slow Inactivation in K+ Channels Controlled by Buried Water Molecules Biophysical Journal. 104: 25a-26a. DOI: 10.1016/J.Bpj.2012.11.174  0.726
2012 Velisetty P, Chalamalasetti SV, Chakrapani S. Conformational transitions underlying pore opening and desensitization in membrane-embedded Gloeobacter violaceus ligand-gated ion channel (GLIC). The Journal of Biological Chemistry. 287: 36864-72. PMID 22977232 DOI: 10.1074/jbc.M112.401067  0.563
2012 Velisetty P, Chakrapani S. Desensitization mechanism in prokaryotic ligand-gated ion channel. The Journal of Biological Chemistry. 287: 18467-77. PMID 22474322 DOI: 10.1074/jbc.M112.348045  0.655
2012 Velisetty P, Chakrapani S. Characterization of Gating Mechanisms in Prokaryotic Pentameric Ligand-Gated Ion Channels Biophysical Journal. 102: 114a. DOI: 10.1016/J.BPJ.2011.11.641  0.69
2011 Cordero-Morales JF, Jogini V, Chakrapani S, Perozo E. A multipoint hydrogen-bond network underlying KcsA C-type inactivation. Biophysical Journal. 100: 2387-93. PMID 21575572 DOI: 10.1016/J.Bpj.2011.01.073  0.821
2011 Chakrapani S, Cordero-Morales JF, Jogini V, Pan AC, Cortes DM, Roux B, Perozo E. On the structural basis of modal gating behavior in K(+) channels. Nature Structural & Molecular Biology. 18: 67-74. PMID 21186363 DOI: 10.1038/Nsmb.1968  0.833
2010 Cuello LG, Jogini V, Cortes DM, Pan AC, Gagnon DG, Dalmas O, Cordero-Morales JF, Chakrapani S, Roux B, Perozo E. Structural basis for the coupling between activation and inactivation gates in K(+) channels. Nature. 466: 272-5. PMID 20613845 DOI: 10.1038/Nature09136  0.793
2010 Chakrapani S, Sompornpisut P, Intharathep P, Roux B, Perozo E. The activated state of a sodium channel voltage sensor in a membrane environment. Proceedings of the National Academy of Sciences of the United States of America. 107: 5435-40. PMID 20207950 DOI: 10.1073/Pnas.0914109107  0.818
2010 Pan AC, Chakrapani S, Jogini V, Cuello LG, Cortes DM, Perozo E, Roux B. The Importance of Ion Binding for Potassium Channel Inactivation and Recovery Biophysical Journal. 98: 621a. DOI: 10.1016/J.Bpj.2009.12.3400  0.827
2010 Chakrapani S, Jogini V, Perozo E. Effect of Altered Ion Occupancy on Permeation and Inactivation Gating in K+ Channel Biophysical Journal. 98: 520a. DOI: 10.1016/J.BPJ.2009.12.2828  0.839
2009 Chakrapani S, Jogini V, Cuello LG, Cortes M, Perozo E. On the Structure-Function correlates of Ion Occupancy and modulation of C-type Inactivation Biophysical Journal. 96: 657a. DOI: 10.1016/J.Bpj.2008.12.3471  0.837
2009 Cuello LG, Chakrapani S, Cortes DM, Dalmas O, Perozo E. Influence Of The Kcsa C-terminal Domain In The Coupling Between Activation And Inactivation Gates Biophysical Journal. 96: 657a. DOI: 10.1016/J.Bpj.2008.12.3470  0.836
2009 Cuello LG, Jogini V, Cortes DM, Pan AC, Gagnon DG, Cordero-Morales JF, Chakrapani S, Roux B, Perozo E. Structural Basis For The Coupling Between Activation And Inactivation Gating In Potassium Channels Biophysical Journal. 96: 381a. DOI: 10.1016/J.Bpj.2008.12.2852  0.825
2008 Chakrapani S, Cuello LG, Cortes DM, Perozo E. Structural dynamics of an isolated voltage-sensor domain in a lipid bilayer. Structure (London, England : 1993). 16: 398-409. PMID 18334215 DOI: 10.1016/J.Str.2007.12.015  0.783
2007 Chakrapani S, Cordero-Morales JF, Perozo E. A quantitative description of KcsA gating II: single-channel currents. The Journal of General Physiology. 130: 479-96. PMID 17938231 DOI: 10.1085/Jgp.200709844  0.811
2007 Chakrapani S, Cordero-Morales JF, Perozo E. A quantitative description of KcsA gating I: macroscopic currents. The Journal of General Physiology. 130: 465-78. PMID 17938230 DOI: 10.1085/Jgp.200709843  0.828
2007 Chakrapani S, Perozo E. How to gate an ion channel: lessons from MthK. Nature Structural & Molecular Biology. 14: 180-2. PMID 17334406 DOI: 10.1038/nsmb0307-180  0.752
2005 Chakrapani S, Auerbach A. A speed limit for conformational change of an allosteric membrane protein. Proceedings of the National Academy of Sciences of the United States of America. 102: 87-92. PMID 15618401 DOI: 10.1073/pnas.0406777102  0.684
2004 Chakrapani S, Bailey TD, Auerbach A. Gating dynamics of the acetylcholine receptor extracellular domain. The Journal of General Physiology. 123: 341-56. PMID 15051806 DOI: 10.1085/jgp.200309004  0.618
2003 Chakrapani S, Bailey TD, Auerbach A. The role of loop 5 in acetylcholine receptor channel gating. The Journal of General Physiology. 122: 521-39. PMID 14557402 DOI: 10.1085/jgp.200308885  0.643
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