Christian J. Pike - Publications

Affiliations: 
Neuroscience University of Southern California, Los Angeles, CA, United States 
Area:
Neuroscience

114 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Valencia-Olvera AC, Maldonado Weng J, Christensen A, LaDu MJ, Pike CJ. Role of estrogen in women's Alzheimer's disease risk as modified by APOE. Journal of Neuroendocrinology. e13209. PMID 36420620 DOI: 10.1111/jne.13209  0.357
2022 Rangan P, Lobo F, Parrella E, Rochette N, Morselli M, Stephen TL, Cremonini AL, Tagliafico L, Persia A, Caffa I, Monacelli F, Odetti P, Bonfiglio T, Nencioni A, Pigliautile M, ... ... Pike CJ, et al. Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer's models. Cell Reports. 40: 111417. PMID 36170815 DOI: 10.1016/j.celrep.2022.111417  0.334
2022 Yao M, Rosario ER, Soper JC, Pike CJ. Androgens Regulate Tau Phosphorylation Through Phosphatidylinositol 3-Kinase-Protein Kinase B-Glycogen Synthase Kinase 3β Signaling. Neuroscience. PMID 35777535 DOI: 10.1016/j.neuroscience.2022.06.034  0.652
2020 Jiang J, Young K, Pike CJ. Second to fourth digit ratio (2D:4D) is associated with dementia in women. Early Human Development. 149: 105152. PMID 32781308 DOI: 10.1016/J.Earlhumdev.2020.105152  0.341
2020 Luo J, Beam CR, Karlsson IK, Pike CJ, Reynolds CA, Gatz M. Dementia risk in women higher in same-sex than opposite-sex twins. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12049. PMID 32582836 DOI: 10.1002/Dad2.12049  0.36
2020 Christensen A, Liu J, Pike CJ. Aging Reduces Estradiol Protection Against Neural but Not Metabolic Effects of Obesity in Female 3xTg-AD Mice. Frontiers in Aging Neuroscience. 12: 113. PMID 32431604 DOI: 10.3389/Fnagi.2020.00113  0.443
2020 Christensen A, Pike CJ. Staining and Quantification of β-Amyloid Pathology in Transgenic Mouse Models of Alzheimer's Disease. Methods in Molecular Biology (Clifton, N.J.). 2144: 211-221. PMID 32410038 DOI: 10.1007/978-1-0716-0592-9_19  0.444
2019 Stephen TL, Cacciottolo M, Balu D, Morgan TE, LaDu MJ, Finch CE, Pike CJ. APOE genotype and sex affect microglial interactions with plaques in Alzheimer's disease mice. Acta Neuropathologica Communications. 7: 82. PMID 31113487 DOI: 10.1186/S40478-019-0729-Z  0.472
2019 Stephen T, Cacciottolo M, Balu D, Morgan TE, Ladu MJ, Finch CE, Pike CJ. P1-212: MICROGLIAL INTERACTIONS WITH AMYLOID PLAQUES ARE MODULATED BY SEX AND APOE GENOTYPE IN EFAD MICE Alzheimer's & Dementia. 15: P317-P317. DOI: 10.1016/J.Jalz.2019.06.767  0.377
2019 Luo J, Beam CR, Pike CJ, Gatz M. P3-549: SEX DIFFERENCES IN DEMENTIA RISK: THE EFFECTS OF PRENATAL TESTOSTERONE EXPOSURE, APOE4, AND THEIR INTERACTION Alzheimer's & Dementia. 15: P1183-P1184. DOI: 10.1016/J.Jalz.2019.06.3585  0.314
2019 Christensen A, Pike CJ. P2-192: PROTECTIVE EFFECTS OF ESTRADIOL ON METABOLIC AND NEURAL EFFECTS OF OBESITY IN FEMALE APOE3 AND APOE4 MICE AT EARLY MIDDLE AGE Alzheimer's & Dementia. 15: P650-P650. DOI: 10.1016/J.Jalz.2019.06.2599  0.34
2019 Moser VA, Sances S, Morgan TE, Finch CE, Ladu MJ, Pike CJ, Svendsen CN. TRANSCRIPTOMIC PROFILING OF MICROGLIA FROM AN ALZHEIMER'S DISEASE MOUSE MODEL AND FROM HUMAN INDUCED PLURIPOTENT STEM CELLS REVEALS EFFECTS OF THE APOE4 GENOTYPE Alzheimer's & Dementia. 15: P238-P239. DOI: 10.1016/J.Jalz.2019.06.046  0.334
2018 Christensen A, Pike CJ. APOE genotype affects metabolic and Alzheimer-related outcomes induced by Western diet in female EFAD mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201801756R. PMID 30509127 DOI: 10.1096/Fj.201801756R  0.443
2018 Moser VA, Christensen A, Liu J, Zhou A, Yagi S, Beam CR, Galea L, Pike CJ. Effects of aging, high-fat diet, and testosterone treatment on neural and metabolic outcomes in male brown Norway rats. Neurobiology of Aging. 73: 145-160. PMID 30359877 DOI: 10.1016/J.Neurobiolaging.2018.09.016  0.359
2018 Christensen A, Pike CJ. TSPO ligand PK11195 improves Alzheimer-related outcomes in aged female 3xTg-AD mice. Neuroscience Letters. 683: 7-12. PMID 29925037 DOI: 10.1016/J.Neulet.2018.06.029  0.466
2017 Moser VA, Pike CJ. Obesity Accelerates Alzheimer-Related Pathology in APOE4 but not APOE3 Mice. Eneuro. 4. PMID 28612048 DOI: 10.1523/ENEURO.0077-17.2017  0.315
2017 Christensen A, Pike CJ. Age-dependent regulation of obesity and Alzheimer-related outcomes by hormone therapy in female 3xTg-AD mice. Plos One. 12: e0178490. PMID 28575011 DOI: 10.1371/Journal.Pone.0178490  0.438
2017 Pike CJ. Sex and the development of Alzheimer's disease. Journal of Neuroscience Research. 95: 671-680. PMID 27870425 DOI: 10.1002/Jnr.23827  0.502
2016 Uchoa MF, Alexandra Moser V, Pike CJ. Interactions between inflammation, sex steroids, and Alzheimer's disease risk factors. Frontiers in Neuroendocrinology. PMID 27651175 DOI: 10.1016/J.Yfrne.2016.09.001  0.448
2016 Cacciottolo M, Christensen A, Moser A, Liu J, Pike CJ, Smith C, LaDu MJ, Sullivan PM, Morgan TE, Dolzhenko E, Charidimou A, Wahlund LO, Wiberg MK, Shams S, Chiang GC, et al. The APOE4 allele shows opposite sex bias in microbleeds and Alzheimer's disease of humans and mice. Neurobiology of Aging. 37: 47-57. PMID 26686669 DOI: 10.1016/J.Neurobiolaging.2015.10.010  0.448
2015 Moser VA, Pike CJ. Obesity and sex interact in the regulation of Alzheimer's disease. Neuroscience and Biobehavioral Reviews. PMID 26708713 DOI: 10.1016/J.Neubiorev.2015.08.021  0.399
2015 Christensen A, Pike CJ. Menopause, obesity and inflammation: interactive risk factors for Alzheimer's disease. Frontiers in Aging Neuroscience. 7: 130. PMID 26217222 DOI: 10.3389/Fnagi.2015.00130  0.412
2015 Yin F, Yao J, Sancheti H, Feng T, Melcangi RC, Morgan TE, Finch CE, Pike CJ, Mack WJ, Cadenas E, Brinton RD. The perimenopausal aging transition in the female rat brain: decline in bioenergetic systems and synaptic plasticity. Neurobiology of Aging. 36: 2282-95. PMID 25921624 DOI: 10.1016/J.Neurobiolaging.2015.03.013  0.339
2015 Barron AM, Brown MA, Morgan TE, Pike CJ. Impact of continuous versus discontinuous progesterone on estradiol regulation of neuron viability and sprouting after entorhinal cortex lesion in female rats. Endocrinology. 156: 1091-9. PMID 25514084 DOI: 10.1210/En.2014-1216  0.348
2014 Jayaraman A, Lent-Schochet D, Pike CJ. Diet-induced obesity and low testosterone increase neuroinflammation and impair neural function. Journal of Neuroinflammation. 11: 162. PMID 25224590 DOI: 10.1186/S12974-014-0162-Y  0.581
2014 Jayaraman A, Pike CJ. Alzheimer's disease and type 2 diabetes: multiple mechanisms contribute to interactions. Current Diabetes Reports. 14: 476. PMID 24526623 DOI: 10.1007/S11892-014-0476-2  0.586
2014 Jayaraman A, Christensen A, Moser VA, Vest RS, Miller CP, Hattersley G, Pike CJ. Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats. Endocrinology. 155: 1398-406. PMID 24428527 DOI: 10.1210/En.2013-1725  0.636
2014 Jayaraman A, Pike CJ. Differential effects of synthetic progestagens on neuron survival and estrogen neuroprotection in cultured neurons. Molecular and Cellular Endocrinology. 384: 52-60. PMID 24424444 DOI: 10.1016/J.Mce.2014.01.003  0.602
2013 Barron AM, Rosario ER, Elteriefi R, Pike CJ. Sex-specific effects of high fat diet on indices of metabolic syndrome in 3xTg-AD mice: implications for Alzheimer's disease. Plos One. 8: e78554. PMID 24205258 DOI: 10.1016/J.Jalz.2010.08.067  0.663
2013 Barron AM, Garcia-Segura LM, Caruso D, Jayaraman A, Lee JW, Melcangi RC, Pike CJ. Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 8891-7. PMID 23678130 DOI: 10.1523/Jneurosci.1350-13.2013  0.627
2013 Caruso D, Barron AM, Brown MA, Abbiati F, Carrero P, Pike CJ, Garcia-Segura LM, Melcangi RC. Age-related changes in neuroactive steroid levels in 3xTg-AD mice. Neurobiology of Aging. 34: 1080-9. PMID 23122920 DOI: 10.1016/J.Neurobiolaging.2012.10.007  0.492
2013 Vest RS, Pike CJ. Gender, sex steroid hormones, and Alzheimer's disease. Hormones and Behavior. 63: 301-7. PMID 22554955 DOI: 10.1016/J.Yhbeh.2012.04.006  0.53
2013 Jayaraman A, Lent D, Pike C. P2-025: Diet-induced obesity and low testosterone interact to increase neuroinflammation and reduce neuron survival Alzheimer's & Dementia. 9: P353-P353. DOI: 10.1016/J.Jalz.2013.05.667  0.538
2013 Lee J, Rosario E, Jayaraman A, Pike C. P2-024: Obesity and low testosterone interact to increase vulnerability to Alzheimer's disease pathogenesis Alzheimer's & Dementia. 9: P353-P353. DOI: 10.1016/J.Jalz.2013.05.666  0.737
2013 Jayaraman A, Christensen A, Vest R, Miller C, Hattersley G, Pike C. P3-033: Neuroprotective effects of the selective androgen receptor modulator RAD140 in cultured neurons and kainate lesioned rats Alzheimer's & Dementia. 9: P561-P561. DOI: 10.1016/J.Jalz.2013.05.1102  0.561
2013 Barron A, Jayaraman A, Lee J, Hojo Y, Higuchi M, Pike C, Kawato S. O4-10-05: Ligand for translocator protein increases hippocampal expression of glial beta-amyloid scavenger receptors and reduces beta-amyloid in male mice and rats Alzheimer's & Dementia. 9: P703-P703. DOI: 10.1016/J.Jalz.2013.04.393  0.605
2012 Jayaraman A, Carroll JC, Morgan TE, Lin S, Zhao L, Arimoto JM, Murphy MP, Beckett TL, Finch CE, Brinton RD, Pike CJ. 17β-estradiol and progesterone regulate expression of β-amyloid clearance factors in primary neuron cultures and female rat brain. Endocrinology. 153: 5467-79. PMID 22962256 DOI: 10.1210/En.2012-1464  0.744
2012 Rosario ER, Carroll JC, Pike CJ. Evaluation of the effects of testosterone and luteinizing hormone on regulation of β-amyloid in male 3xTg-AD mice. Brain Research. 1466: 137-45. PMID 22587890 DOI: 10.1016/J.Brainres.2012.05.011  0.783
2012 Aras R, Barron AM, Pike CJ. Caspase activation contributes to astrogliosis. Brain Research. 1450: 102-15. PMID 22436850 DOI: 10.1016/J.Brainres.2012.02.056  0.764
2012 Zhao L, Morgan TE, Mao Z, Lin S, Cadenas E, Finch CE, Pike CJ, Mack WJ, Brinton RD. Continuous versus cyclic progesterone exposure differentially regulates hippocampal gene expression and functional profiles. Plos One. 7: e31267. PMID 22393359 DOI: 10.1371/Journal.Pone.0031267  0.359
2012 Barron AM, Pike CJ. Sex hormones, aging, and Alzheimer's disease. Frontiers in Bioscience (Elite Edition). 4: 976-97. PMID 22201929 DOI: 10.2741/434  0.486
2011 Rosario ER, Chang L, Head EH, Stanczyk FZ, Pike CJ. Brain levels of sex steroid hormones in men and women during normal aging and in Alzheimer's disease. Neurobiology of Aging. 32: 604-13. PMID 19428144 DOI: 10.1016/J.Neurobiolaging.2009.04.008  0.695
2010 Aguirre C, Jayaraman A, Pike C, Baudry M. Progesterone inhibits estrogen-mediated neuroprotection against excitotoxicity by down-regulating estrogen receptor-β. Journal of Neurochemistry. 115: 1277-87. PMID 20977477 DOI: 10.1111/J.1471-4159.2010.07038.X  0.583
2010 Carroll JC, Rosario ER, Kreimer S, Villamagna A, Gentzschein E, Stanczyk FZ, Pike CJ. Sex differences in β-amyloid accumulation in 3xTg-AD mice: role of neonatal sex steroid hormone exposure. Brain Research. 1366: 233-45. PMID 20934413 DOI: 10.1016/J.Brainres.2010.10.009  0.779
2010 Rosario ER, Carroll J, Pike CJ. Testosterone regulation of Alzheimer-like neuropathology in male 3xTg-AD mice involves both estrogen and androgen pathways. Brain Research. 1359: 281-90. PMID 20807511 DOI: 10.1016/J.Brainres.2010.08.068  0.799
2010 Nguyen TV, Jayaraman A, Quaglino A, Pike CJ. Androgens selectively protect against apoptosis in hippocampal neurones. Journal of Neuroendocrinology. 22: 1013-22. PMID 20561156 DOI: 10.1111/J.1365-2826.2010.02044.X  0.729
2010 Carroll JC, Rosario ER, Villamagna A, Pike CJ. Continuous and cyclic progesterone differentially interact with estradiol in the regulation of Alzheimer-like pathology in female 3xTransgenic-Alzheimer's disease mice. Endocrinology. 151: 2713-22. PMID 20410196 DOI: 10.1210/En.2009-1487  0.795
2009 Rosario ER, Chang L, Beckett TL, Carroll JC, Paul Murphy M, Stanczyk FZ, Pike CJ. Age-related changes in serum and brain levels of androgens in male Brown Norway rats. Neuroreport. 20: 1534-7. PMID 19829160 DOI: 10.1097/Wnr.0B013E328331F968  0.767
2009 Nguyen TV, Yao M, Pike CJ. Dihydrotestosterone activates CREB signaling in cultured hippocampal neurons. Brain Research. 1298: 1-12. PMID 19729001 DOI: 10.1016/J.Brainres.2009.08.066  0.651
2009 Pike CJ, Carroll JC, Rosario ER, Barron AM. Protective actions of sex steroid hormones in Alzheimer's disease. Frontiers in Neuroendocrinology. 30: 239-58. PMID 19427328 DOI: 10.1016/J.Yfrne.2009.04.015  0.804
2009 Jayaraman A, Pike CJ. Progesterone attenuates oestrogen neuroprotection via downregulation of oestrogen receptor expression in cultured neurones. Journal of Neuroendocrinology. 21: 77-81. PMID 19094096 DOI: 10.1111/J.1365-2826.2008.01801.X  0.609
2009 Pike CJ, Rosario ER. Testosterone regulates Alzheimer's disease pathogenesis Hormones, Cognition and Dementia: State of the Art and Emergent Therapeutic Strategies. 242-249. DOI: 10.1017/CBO9780511635700.026  0.688
2009 Pike CJ, Carroll JC. Progesterone regulation of neuroprotective estrogen actions Hormones, Cognition and Dementia: State of the Art and Emergent Therapeutic Strategies. 101-109. DOI: 10.1017/CBO9780511635700.012  0.63
2009 Rosario ER, Carroll JC, Brown MA, Barron AM, Pike CJ. P4-333: Dietary induction of type 2 diabetes increases AD-like pathology in male 3xTg-AD mice Alzheimer's & Dementia. 5: e28-e29. DOI: 10.1016/j.jalz.2009.07.112  0.742
2009 Rosario ER, Carroll JC, Brown MA, Barron AM, Pike CJ. P4-034: Dietary induction of type 2 diabetes increases Alzheimer-like pathology in male 3xTg-AD mice Alzheimer's & Dementia. 5: P441-P441. DOI: 10.1016/J.Jalz.2009.04.904  0.755
2009 Carroll JC, Rosario ER, Villamagna A, Gentzschein E, Stanczyk FZ, Pike CJ. P2-248: Continuous and cyclic progesterone differentially affect estrogen regulation of Alzheimer-like pathology in female 3xTg-AD mice Alzheimer's & Dementia. 5: P333-P333. DOI: 10.1016/J.Jalz.2009.04.561  0.782
2008 Carroll JC, Rosario ER, Pike CJ. Progesterone blocks estrogen neuroprotection from kainate in middle-aged female rats. Neuroscience Letters. 445: 229-32. PMID 18790007 DOI: 10.1016/J.Neulet.2008.09.010  0.761
2008 Brinton RD, Thompson RF, Foy MR, Baudry M, Wang J, Finch CE, Morgan TE, Pike CJ, Mack WJ, Stanczyk FZ, Nilsen J. Progesterone receptors: form and function in brain. Frontiers in Neuroendocrinology. 29: 313-39. PMID 18374402 DOI: 10.1016/J.Yfrne.2008.02.001  0.357
2008 Yao M, Nguyen TV, Rosario ER, Ramsden M, Pike CJ. Androgens regulate neprilysin expression: role in reducing beta-amyloid levels. Journal of Neurochemistry. 105: 2477-88. PMID 18346198 DOI: 10.1111/J.1471-4159.2008.05341.X  0.793
2008 Carroll JC, Pike CJ. Selective estrogen receptor modulators differentially regulate Alzheimer-like changes in female 3xTg-AD mice. Endocrinology. 149: 2607-11. PMID 18276750 DOI: 10.1210/En.2007-1346  0.696
2008 Pike CJ, Nguyen TV, Ramsden M, Yao M, Murphy MP, Rosario ER. Androgen cell signaling pathways involved in neuroprotective actions. Hormones and Behavior. 53: 693-705. PMID 18222446 DOI: 10.1016/J.Yhbeh.2007.11.006  0.802
2008 Rosario ER, Pike CJ. Androgen regulation of beta-amyloid protein and the risk of Alzheimer's disease. Brain Research Reviews. 57: 444-53. PMID 17658612 DOI: 10.1016/J.Brainresrev.2007.04.012  0.741
2008 Rosario ER, Carroll JC, Chang L, Stanczyk FZ, Pike CJ. O4-02-07: Androgens but not leuprolide protect against Abeta accumulation in male triple transgenic mice Alzheimer's & Dementia. 4: T188-T188. DOI: 10.1016/J.Jalz.2008.05.515  0.757
2008 Carroll JC, Pike CJ. P1-435: Selective estrogen receptor modulators differentially regulate Alzheimer-like neuropathology in female triple transgenic mice Alzheimer's & Dementia. 4: T347-T347. DOI: 10.1016/J.Jalz.2008.05.1017  0.65
2007 Carroll JC, Rosario ER, Chang L, Stanczyk FZ, Oddo S, LaFerla FM, Pike CJ. Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 13357-65. PMID 18045930 DOI: 10.1523/Jneurosci.2718-07.2007  0.802
2007 Nguyen TV, Yao M, Pike CJ. Flutamide and cyproterone acetate exert agonist effects: induction of androgen receptor-dependent neuroprotection. Endocrinology. 148: 2936-43. PMID 17347309 DOI: 10.1210/En.2006-1469  0.665
2007 Yao M, Nguyen TV, Pike CJ. Estrogen regulates Bcl-w and Bim expression: role in protection against beta-amyloid peptide-induced neuronal death. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 1422-33. PMID 17287517 DOI: 10.1523/Jneurosci.2382-06.2007  0.703
2007 Chen MJ, Nguyen TV, Pike CJ, Russo-Neustadt AA. Norepinephrine induces BDNF and activates the PI-3K and MAPK cascades in embryonic hippocampal neurons Cellular Signalling. 19: 114-128. PMID 16876982 DOI: 10.1016/J.Cellsig.2006.05.028  0.64
2006 Rosario ER, Carroll JC, Oddo S, LaFerla FM, Pike CJ. Androgens regulate the development of neuropathology in a triple transgenic mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 13384-9. PMID 17182789 DOI: 10.1523/Jneurosci.2514-06.2006  0.793
2006 Rosario ER, Ramsden M, Pike CJ. Progestins inhibit the neuroprotective effects of estrogen in rat hippocampus. Brain Research. 1099: 206-10. PMID 16793026 DOI: 10.1016/J.Brainres.2006.03.127  0.654
2006 Pike CJ, Rosario ER, Nguyen TV. Androgens, aging, and Alzheimer's disease. Endocrine. 29: 233-41. PMID 16785599 DOI: 10.1385/Endo:29:2:233  0.806
2006 Cordey M, Pike CJ. Conventional protein kinase C isoforms mediate neuroprotection induced by phorbol ester and estrogen. Journal of Neurochemistry. 96: 204-17. PMID 16336227 DOI: 10.1111/J.1471-4159.2005.03545.X  0.801
2006 Rosario ER, Carroll JC, Chang L, Stanczyk F, Oddo S, LaFerla F, Pike CJ. P1-252: Androgens regulate development of neuropathology in a mouse model of Alzheimer's disease Alzheimer's & Dementia. 2: S170-S170. DOI: 10.1016/J.Jalz.2006.05.629  0.747
2005 Nguyen TV, Yao M, Pike CJ. Androgens activate mitogen-activated protein kinase signaling: role in neuroprotection. Journal of Neurochemistry. 94: 1639-51. PMID 16011741 DOI: 10.1111/J.1471-4159.2005.03318.X  0.676
2005 Cordey M, Pike CJ. Neuroprotective properties of selective estrogen receptor agonists in cultured neurons. Brain Research. 1045: 217-23. PMID 15910780 DOI: 10.1016/J.Brainres.2005.03.032  0.799
2005 Cordey M, Gundimeda U, Gopalakrishna R, Pike CJ. The synthetic estrogen 4-estren-3 alpha,17 beta-diol (estren) induces estrogen-like neuroprotection. Neurobiology of Disease. 19: 331-9. PMID 15837589 DOI: 10.1016/J.Nbd.2005.01.011  0.804
2005 Yao M, Nguyen TV, Pike CJ. Beta-amyloid-induced neuronal apoptosis involves c-Jun N-terminal kinase-dependent downregulation of Bcl-w. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 1149-58. PMID 15689551 DOI: 10.1523/Jneurosci.4736-04.2005  0.685
2005 Pike CJ, Rosario ER, Stanczyk FZ. Dementia and Testosterone Levels in Men—Reply Jama. 293: 551-552. DOI: 10.1001/Jama.293.5.552-A  0.633
2004 Rosario ER, Chang L, Stanczyk FZ, Pike CJ. Age-related testosterone depletion and the development of Alzheimer disease. Jama. 292: 1431-2. PMID 15383512 DOI: 10.1001/Jama.292.12.1431-B  0.664
2003 Ramsden M, Shin TM, Pike CJ. Androgens modulate neuronal vulnerability to kainate lesion. Neuroscience. 122: 573-8. PMID 14622899 DOI: 10.1016/J.Neuroscience.2003.08.048  0.372
2003 Ramsden M, Nyborg AC, Murphy MP, Chang L, Stanczyk FZ, Golde TE, Pike CJ. Androgens modulate beta-amyloid levels in male rat brain. Journal of Neurochemistry. 87: 1052-5. PMID 14622134 DOI: 10.1046/J.1471-4159.2003.02114.X  0.481
2003 Ramsden M, Berchtold NC, Patrick Kesslak J, Cotman CW, Pike CJ. Exercise increases the vulnerability of rat hippocampal neurons to kainate lesion. Brain Research. 971: 239-44. PMID 12706240 DOI: 10.1016/S0006-8993(03)02365-5  0.304
2003 Cordey M, Gundimeda U, Gopalakrishna R, Pike CJ. Estrogen activates protein kinase C in neurons: role in neuroprotection. Journal of Neurochemistry. 84: 1340-8. PMID 12614334 DOI: 10.1046/J.1471-4159.2003.01631.X  0.812
2002 Soreghan B, Pike C, Kayed R, Tian W, Milton S, Cotman C, Glabe CG. The influence of the carboxyl terminus of the Alzheimer Abeta peptide on its conformation, aggregation, and neurotoxic properties. Neuromolecular Medicine. 1: 81-94. PMID 12025818 DOI: 10.1385/Nmm:1:1:81  0.375
2001 Berchtold NC, Kesslak JP, Pike CJ, Adlard PA, Cotman CW. Estrogen and exercise interact to regulate brain-derived neurotrophic factor mRNA and protein expression in the hippocampus. The European Journal of Neuroscience. 14: 1992-2002. PMID 11860494 DOI: 10.1046/J.0953-816X.2001.01825.X  0.345
2001 Pike CJ. Testosterone attenuates β-amyloid toxicity in cultured hippocampal neurons Brain Research. 919: 160-165. PMID 11689174 DOI: 10.1016/S0006-8993(01)03024-4  0.446
2001 Stoltzner SE, Berchtold NC, Cotman CW, Pike CJ. Estrogen regulates bcl-x expression in rat hippocampus. Neuroreport. 12: 2797-800. PMID 11588579 DOI: 10.1097/00001756-200109170-00009  0.373
1999 Pike CJ. Estrogen modulates neuronal Bcl-x(L) expression and β-amyloid-induced apoptosis: Relevance to Alzheimer's disease Journal of Neurochemistry. 72: 1552-1563. PMID 10098861 DOI: 10.1046/J.1471-4159.1999.721552.X  0.451
1997 Pike CJ, Ramezan-Arab N, Cotman CW. Beta-amyloid neurotoxicity in vitro: evidence of oxidative stress but not protection by antioxidants. Journal of Neurochemistry. 69: 1601-11. PMID 9326289 DOI: 10.1046/J.1471-4159.1997.69041601.X  0.381
1997 Donovan FM, Pike CJ, Cotman CW, Cunningham DD. Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 5316-26. PMID 9204916 DOI: 10.1523/Jneurosci.17-14-05316.1997  0.36
1997 Cribbs DH, Pike CJ, Weinstein SL, Velazquez P, Cotman CW. All-D-enantiomers of beta-amyloid exhibit similar biological properties to all-L-beta-amyloids. The Journal of Biological Chemistry. 272: 7431-6. PMID 9054444 DOI: 10.1074/Jbc.272.11.7431  0.38
1996 Cummings BJ, Pike CJ, Shankle R, Cotman CW. Beta-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease. Neurobiology of Aging. 17: 921-33. PMID 9363804 DOI: 10.1016/S0197-4580(96)00170-4  0.368
1996 Deng G, Pike CJ, Cotman CW. Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells. Febs Letters. 397: 50-4. PMID 8941712 DOI: 10.1016/S0014-5793(96)01142-8  0.326
1996 Pike CJ, Balázs R, Cotman CW. Attenuation of beta-amyloid neurotoxicity in vitro by potassium-induced depolarization. Journal of Neurochemistry. 67: 1774-7. PMID 8858966 DOI: 10.1046/J.1471-4159.1996.67041774.X  0.406
1996 Pike CJ, Ramezan-Arab N, Miller S, Cotman CW. beta-Amyloid increases enzyme activity and protein levels of glutamine synthetase in cultured astrocytes. Experimental Neurology. 139: 167-71. PMID 8635563 DOI: 10.1006/Exnr.1996.0091  0.387
1996 Pike CJ, Vaughan PJ, Cunningham DD, Cotman CW. Thrombin attenuates neuronal cell death and modulates astrocyte reactivity induced by beta-amyloid in vitro. Journal of Neurochemistry. 66: 1374-82. PMID 8627288 DOI: 10.1046/J.1471-4159.1996.66041374.X  0.429
1996 Cummings B, Pike C, Cotman C. 722 Multiple neuropathological variables are correlated with the level of cognitive impairment in Alzheimer's disease Neurobiology of Aging. 17: S179. DOI: 10.1016/S0197-4580(96)80724-X  0.308
1995 Pike CJ, Walencewicz-Wasserman AJ, Kosmoski J, Cribbs DH, Glabe CG, Cotman CW. Structure-activity analyses of beta-amyloid peptides: contributions of the beta 25-35 region to aggregation and neurotoxicity. Journal of Neurochemistry. 64: 253-65. PMID 7798921 DOI: 10.1046/J.1471-4159.1995.64010253.X  0.37
1995 Pike CJ, Cummings BJ, Cotman CW. Early association of reactive astrocytes with senile plaques in Alzheimer's disease. Experimental Neurology. 132: 172-9. PMID 7789457 DOI: 10.1016/0014-4886(95)90022-5  0.476
1995 Pike CJ, Cotman CW. Calretinin-immunoreactive neurons are resistant to beta-amyloid toxicity in vitro. Brain Research. 671: 293-8. PMID 7743217 DOI: 10.1016/0006-8993(94)01354-K  0.376
1995 Vaughan PJ, Pike CJ, Cotman CW, Cunningham DD. Thrombin receptor activation protects neurons and astrocytes from cell death produced by environmental insults. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 5389-401. PMID 7623161 DOI: 10.1523/Jneurosci.15-07-05389.1995  0.369
1995 Pike CJ, Overman MJ, Cotman CW. Amino-terminal deletions enhance aggregation of beta-amyloid peptides in vitro. The Journal of Biological Chemistry. 270: 23895-8. PMID 7592576 DOI: 10.1074/Jbc.270.41.23895  0.339
1995 Anderson AJ, Pike CJ, Cotman CW. Differential induction of immediate early gene proteins in cultured neurons by beta-amyloid (A beta): association of c-Jun with A beta-induced apoptosis. Journal of Neurochemistry. 65: 1487-98. PMID 7561842 DOI: 10.1046/J.1471-4159.1995.65041487.X  0.408
1994 Weiss JH, Pike CJ, Cotman CW. Ca2+ channel blockers attenuate beta-amyloid peptide toxicity to cortical neurons in culture. Journal of Neurochemistry. 62: 372-5. PMID 8263540 DOI: 10.1046/J.1471-4159.1994.62010372.X  0.356
1994 Pike CJ, Cummings BJ, Monzavi R, Cotman CW. Beta-amyloid-induced changes in cultured astrocytes parallel reactive astrocytosis associated with senile plaques in Alzheimer's disease. Neuroscience. 63: 517-31. PMID 7891862 DOI: 10.1016/0306-4522(94)90547-9  0.44
1994 Watt JA, Pike CJ, Walencewicz-Wasserman AJ, Cotman CW. Ultrastructural analysis of beta-amyloid-induced apoptosis in cultured hippocampal neurons. Brain Research. 661: 147-56. PMID 7834365 DOI: 10.1016/0006-8993(94)91191-6  0.379
1993 Pike CJ, Burdick D, Walencewicz AJ, Glabe CG, Cotman CW. Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 1676-87. PMID 8463843 DOI: 10.1523/Jneurosci.13-04-01676.1993  0.381
1993 Loo DT, Copani A, Pike CJ, Whittemore ER, Walencewicz AJ, Cotman CW. Apoptosis is induced by beta-amyloid in cultured central nervous system neurons. Proceedings of the National Academy of Sciences of the United States of America. 90: 7951-5. PMID 8367446 DOI: 10.1073/Pnas.90.17.7951  0.428
1993 Korotzer AR, Pike CJ, Cotman CW. beta-Amyloid peptides induce degeneration of cultured rat microglia. Brain Research. 624: 121-5. PMID 8252383 DOI: 10.1016/0006-8993(93)90068-X  0.394
1993 Pike CJ, Cotman CW. Cultured GABA-immunoreactive neurons are resistant to toxicity induced by beta-amyloid. Neuroscience. 56: 269-74. PMID 8247260 DOI: 10.1016/0306-4522(93)90331-9  0.437
1992 Cotman CW, Pike CJ, Copani A. β-Amyloid neurotoxicity: A discussion of in vitro findings Neurobiology of Aging. 13: 587-590. PMID 1461347 DOI: 10.1016/0197-4580(92)90060-B  0.425
1992 Pike CJ, Cummings BJ, Cotman CW. µ-Amyloid induces neuritic dystrophy in vitro: Similarities with alzherimer pathology Neuroreport. 3: 769-772. PMID 1421135 DOI: 10.1097/00001756-199209000-00012  0.44
1991 Pike CJ, Walencewicz AJ, Glabe CG, Cotman CW. In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity. Brain Research. 563: 311-4. PMID 1786545 DOI: 10.1016/0006-8993(91)91553-D  0.384
1991 Pike CJ, Walencewicz AJ, Glabe CG, Cotman CW. Aggregation-related toxicity of synthetic beta-amyloid protein in hippocampal cultures. European Journal of Pharmacology. 207: 367-8. PMID 1783006 DOI: 10.1016/0922-4106(91)90014-9  0.36
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