Anumantha G. Kanthasamy - Publications

Affiliations: 
Neuroscience Iowa State University, Ames, IA, United States 
Area:
Neuroscience, Toxicology

167 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Huang M, Bargues-Carot A, Riaz Z, Wickham H, Zenitsky G, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Impact of Environmental Risk Factors on Mitochondrial Dysfunction, Neuroinflammation, Protein Misfolding, and Oxidative Stress in the Etiopathogenesis of Parkinson's Disease. International Journal of Molecular Sciences. 23. PMID 36142718 DOI: 10.3390/ijms231810808  0.334
2022 Palanisamy BN, Sarkar S, Malovic E, Samidurai M, Charli A, Zenitsky G, Jin H, Anantharam V, Kanthasamy A, Kanthasamy A. Environmental Neurotoxic Pesticide Exposure Induces Gut Inflammation and Enteric Neuronal Degeneration by Impairing Enteric Glial Mitochondrial Function in Pesticide Models of Parkinson's Disease: Potential Relevance to Gut-Brain Axis Inflammation in Parkinson's Disease Pathogenesis. The International Journal of Biochemistry & Cell Biology. 106225. PMID 35550926 DOI: 10.1016/j.biocel.2022.106225  0.78
2021 Huang M, Lou D, Charli A, Kong D, Jin H, Zenitsky G, Anantharam V, Kanthasamy A, Wang Z, Kanthasamy AG. Mitochondrial dysfunction-induced H3K27 hyperacetylation perturbs enhancers in Parkinson's disease. Jci Insight. 6. PMID 34494552 DOI: 10.1172/jci.insight.138088  0.371
2021 Ghaisas S, Harischandra DS, Palanisamy B, Proctor A, Jin H, Dutta S, Sarkar S, Langley M, Zenitsky G, Anantharam V, Kanthasamy A, Phillips GJ, Kanthasamy A. Chronic Manganese Exposure and the Enteric Nervous System: An and Mouse Study. Environmental Health Perspectives. 129: 87005. PMID 34410835 DOI: 10.1289/EHP7877  0.777
2021 Schlichtmann BW, Kalyanaraman B, Schlichtmann RL, Panthani MG, Anantharam V, Kanthasamy AG, Mallapragada SK, Narasimhan B. Functionalized polyanhydride nanoparticles for improved treatment of mitochondrial dysfunction. Journal of Biomedical Materials Research. Part B, Applied Biomaterials. PMID 34312984 DOI: 10.1002/jbm.b.34922  0.314
2021 Samidurai M, Palanisamy BN, Bargues-Carot A, Hepker M, Kondru N, Manne S, Zenitsky G, Jin H, Anantharam V, Kanthasamy AG, Kanthasamy A. PKC Delta Activation Promotes Endoplasmic Reticulum Stress (ERS) and NLR Family Pyrin Domain-Containing 3 (NLRP3) Inflammasome Activation Subsequent to Asynuclein-Induced Microglial Activation: Involvement of Thioredoxin-Interacting Protein (TXNIP)/Thioredoxin (Trx) Redoxisome Pathway. Frontiers in Aging Neuroscience. 13: 661505. PMID 34276337 DOI: 10.3389/fnagi.2021.661505  0.437
2021 Saminathan H, Ghosh A, Zhang D, Song C, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Fyn Kinase-Mediated PKCδ Y311 Phosphorylation Induces Dopaminergic Degeneration in Cell Culture and Animal Models: Implications for the Identification of a New Pharmacological Target for Parkinson's Disease. Frontiers in Pharmacology. 12: 631375. PMID 33995031 DOI: 10.3389/fphar.2021.631375  0.847
2020 Manne S, Kondru N, Jin H, Serrano GE, Anantharam V, Kanthasamy A, Adler CH, Beach TG, Kanthasamy AG. Blinded RT-QuIC Analysis of α-Synuclein Biomarker in Skin Tissue from Parkinson's Disease Patients. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 32960470 DOI: 10.1002/Mds.28242  0.364
2020 Samidurai M, Tarale P, Janarthanam C, Estrada CG, Gordon R, Zenitsky G, Jin H, Anantharam V, Kanthasamy AG, Kanthasamy A. Tumor Necrosis Factor-Like Weak Inducer of Apoptosis (TWEAK) Enhances Activation of STAT3/NLRC4 Inflammasome Signaling Axis through PKCδ in Astrocytes: Implications for Parkinson's Disease. Cells. 9. PMID 32759670 DOI: 10.3390/Cells9081831  0.538
2020 Sarkar S, Nguyen HM, Malovic E, Luo J, Langley M, Palanisamy BN, Singh N, Manne S, Neal M, Gabrielle M, Abdalla A, Anantharam P, Rokad D, Panicker N, Singh V, ... ... Kanthasamy AG, et al. Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson's disease. The Journal of Clinical Investigation. PMID 32597830 DOI: 10.1172/Jci136174  0.818
2020 Saminathan H, Charli A, Luo J, Panicker N, Gordon R, Hostetter JM, Jin H, Anantharam V, Kanthasamy AG, Kanthasamy A. Fyn kinase mediates pro-inflammatory response in a mouse model of endotoxemia: Relevance to translational research. European Journal of Pharmacology. 173259. PMID 32565338 DOI: 10.1016/J.Ejphar.2020.173259  0.798
2020 Kondru N, Manne S, Kokemuller R, Greenlee J, Greenlee MHW, Nichols T, Kong Q, Anantharam V, Kanthasamy A, Halbur P, Kanthasamy AG. An Ex Vivo Brain Slice Culture Model of Chronic Wasting Disease: Implications for Disease Pathogenesis and Therapeutic Development. Scientific Reports. 10: 7640. PMID 32376941 DOI: 10.1038/S41598-020-64456-9  0.343
2020 Sarkar S, Dammer EB, Malovic E, Olsen AL, Raza SA, Gao T, Xiao H, Oliver DL, Duong D, Joers V, Seyfried N, Huang M, Kukar T, Tansey MG, Kanthasamy AG, et al. Molecular Signatures of Neuroinflammation Induced by αSynuclein Aggregates in Microglial Cells. Frontiers in Immunology. 11: 33. PMID 32082315 DOI: 10.1096/Fasebj.2020.34.S1.00630  0.791
2019 Manne S, Kondru N, Jin H, Anantharam V, Huang X, Kanthasamy A, Kanthasamy AG. α-Synuclein real-time quaking-induced conversion in the submandibular glands of Parkinson's disease patients. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 31758740 DOI: 10.1002/Mds.27907  0.406
2019 Ghaisas S, Langley MR, Palanisamy BN, Dutta S, Narayanaswamy K, Plummer PJ, Sarkar S, Ay M, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. MitoPark Transgenic Mouse Model Recapitulates the Gastrointestinal Dysfunction and Gut-Microbiome Changes of Parkinson's Disease. Neurotoxicology. PMID 31505196 DOI: 10.1016/J.Neuro.2019.09.004  0.77
2019 Panicker N, Kanthasamy A, Kanthasamy AG. Fyn amplifies NLRP3 inflammasome signaling in Parkinson's disease. Aging. PMID 31454793 DOI: 10.18632/aging.102210  0.688
2019 Harischandra DS, Rokad D, Ghaisas S, Verma S, Robertson A, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Enhanced differentiation of human dopaminergic neuronal cell model for preclinical translational research in Parkinson's disease. Biochimica Et Biophysica Acta. Molecular Basis of Disease. 165533. PMID 31442530 DOI: 10.1016/J.Bbadis.2019.165533  0.779
2019 Harischandra DS, Ghaisas S, Zenitsky G, Jin H, Kanthasamy A, Anantharam V, Kanthasamy AG. Manganese-Induced Neurotoxicity: New Insights Into the Triad of Protein Misfolding, Mitochondrial Impairment, and Neuroinflammation. Frontiers in Neuroscience. 13: 654. PMID 31293375 DOI: 10.3389/Fnins.2019.00654  0.798
2019 Ambrosini YM, Borcherding D, Kanthasamy A, Kim HJ, Willette AA, Jergens A, Allenspach K, Mochel JP. The Gut-Brain Axis in Neurodegenerative Diseases and Relevance of the Canine Model: A Review. Frontiers in Aging Neuroscience. 11: 130. PMID 31275138 DOI: 10.3389/Fnagi.2019.00130  0.345
2019 Richardson JR, Fitsanakis V, Westerink RHS, Kanthasamy AG. Neurotoxicity of pesticides. Acta Neuropathologica. PMID 31197504 DOI: 10.1007/S00401-019-02033-9  0.548
2019 Rokad D, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Exosomes as Mediators of Chemical-Induced Toxicity. Current Environmental Health Reports. PMID 31102182 DOI: 10.1007/S40572-019-00233-9  0.365
2019 Panicker N, Sarkar S, Harischandra DS, Neal M, Kam TI, Jin H, Saminathan H, Langley M, Charli A, Samidurai M, Rokad D, Ghaisas S, Pletnikova O, Dawson VL, Dawson TM, ... ... Kanthasamy AG, ... ... Kanthasamy A, et al. Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia. The Journal of Experimental Medicine. PMID 31036561 DOI: 10.1084/Jem.20182191  0.822
2019 Xu Q, Kanthasamy AG, Reddy MB. Epigallocatechin Gallate Protects against TNFα- or HO- Induced Apoptosis by Modulating Iron Related Proteins in a Cell Culture Model. International Journal For Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition. 1-8. PMID 30961459 DOI: 10.1024/0300-9831/A000493  0.469
2019 Luo J, Padhi P, Jin H, Anantharam V, Zenitsky G, Wang Q, Willette AA, Kanthasamy A, Kanthasamy AG. Utilization of the CRISPR-Cas9 Gene Editing System to Dissect Neuroinflammatory and Neuropharmacological Mechanisms in Parkinson's Disease. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. PMID 30879240 DOI: 10.1007/S11481-019-09844-3  0.457
2019 Harischandra DS, Rokad D, Neal ML, Ghaisas S, Manne S, Sarkar S, Panicker N, Zenitsky G, Jin H, Lewis M, Huang X, Anantharam V, Kanthasamy A, Kanthasamy AG. Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein. Science Signaling. 12. PMID 30862700 DOI: 10.1126/Scisignal.Aau4543  0.819
2019 Massey N, Puttachary S, Mahadev-Bhat S, Kanthasamy AG, Charavaryamath C. HMGB1-RAGE Signaling Plays a Role in Organic Dust-Induced Microglial Activation and Neuroinflammation. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 30859215 DOI: 10.1093/Toxsci/Kfz071  0.401
2019 Song C, Charli A, Luo J, Riaz Z, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Mechanistic Interplay between Autophagy and Apoptotic Signaling in Endosulfan-induced Dopaminergic Neurotoxicity: Relevance to the Adverse Outcome Pathway in Pesticide Neurotoxicity. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 30796443 DOI: 10.1093/Toxsci/Kfz049  0.822
2019 Manne S, Kondru N, Hepker M, Jin H, Anantharam V, Lewis M, Huang X, Kanthasamy A, Kanthasamy AG. Ultrasensitive Detection of Aggregated α-Synuclein in Glial Cells, Human Cerebrospinal Fluid, and Brain Tissue Using the RT-QuIC Assay: New High-Throughput Neuroimmune Biomarker Assay for Parkinsonian Disorders. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. PMID 30706414 DOI: 10.1007/S11481-019-09835-4  0.411
2019 Kanthasamy A, Jin H, Charli A, Vellareddy A, Kanthasamy A. Environmental neurotoxicant-induced dopaminergic neurodegeneration: a potential link to impaired neuroinflammatory mechanisms. Pharmacology & Therapeutics. PMID 30677475 DOI: 10.1016/J.Pharmthera.2019.01.001  0.515
2019 Sarkar S, Rokad D, Malovic E, Luo J, Harischandra DS, Jin H, Anantharam V, Huang X, Lewis M, Kanthasamy A, Kanthasamy AG. Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells. Science Signaling. 12. PMID 30622196 DOI: 10.1126/Scisignal.Aat9900  0.813
2019 Le ST, Klinedinst BS, Pappas C, Cerna J, Frizell B, Anatharam V, Kanthasamy A, Willette AA. P2-441: Mitochondrial Bioenergetics And Alzheimer'S Disease: Pyruvate Kinase And Associations With Neural And Cognitive Outcomes Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.2848  0.317
2018 Frederick NM, Shah PV, Didonna A, Langley MR, Kanthasamy AG, Opal P. Loss of the dystonia gene Thap1 leads to transcriptional deficits that converge on common pathogenic pathways in dystonic syndromes. Human Molecular Genetics. PMID 30590536 DOI: 10.1093/Hmg/Ddy433  0.319
2018 Gordon R, Albornoz EA, Christie DC, Langley MR, Kumar V, Mantovani S, Robertson AAB, Butler MS, Rowe DB, O'Neill LA, Kanthasamy AG, Schroder K, Cooper MA, Woodruff TM. Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice. Science Translational Medicine. 10. PMID 30381407 DOI: 10.1126/Scitranslmed.Aah4066  0.513
2018 Neal M, Luo J, Harischandra DS, Gordon R, Sarkar S, Jin H, Anantharam V, Désaubry L, Kanthasamy A, Kanthasamy A. Prokineticin-2 promotes chemotaxis and alternative A2 reactivity of astrocytes. Glia. PMID 30277602 DOI: 10.1002/Glia.23467  0.806
2018 Mammadova N, Summers CM, Kokemuller RD, He Q, Ding S, Baron T, Yu C, Valentine RJ, Sakaguchi DS, Kanthasamy AG, Greenlee JJ, Heather West Greenlee M. Accelerated accumulation of retinal α-synuclein (pSer129) and tau, neuroinflammation and autophagic dysregulation in a seeded mouse model of Parkinson's disease. Neurobiology of Disease. PMID 30218757 DOI: 10.1016/J.Nbd.2018.09.013  0.377
2018 Singh N, Lawana V, Luo J, Phong P, Abdalla A, Palanisamy B, Rokad D, Sarkar S, Jin H, Anantharam V, Kanthasamy AG, Kanthasamy A. Organophosphate pesticide chlorpyrifos impairs STAT1 signaling to induce dopaminergic neurotoxicity: Implications for mitochondria mediated oxidative stress signaling events. Neurobiology of Disease. PMID 29859868 DOI: 10.1016/J.Nbd.2018.05.019  0.801
2018 Sarkar S, Malovic E, Sarda D, Lawana V, Rokad D, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Characterization and comparative analysis of a new mouse microglial cell model for studying neuroinflammatory mechanisms during neurotoxic insults. Neurotoxicology. PMID 29775624 DOI: 10.1016/J.Neuro.2018.05.002  0.777
2018 Zhong X, Luo J, Rastogi P, Kanthasamy AG, Jiles DC, Fellow I. Transcranial magnetic stimulation promotes the proliferation of dopaminergic neuronal cells in vitro Aip Advances. 8: 56709. DOI: 10.1063/1.5007677  0.323
2018 Gordon R, Albornoz E, Kanthasamy A, Woodruff T. C5aR1 is required for α-synuclein mediated NLRP3 inflammasome activation in microglia: Implications for Parkinson's disease Molecular Immunology. 102: 229-229. DOI: 10.1016/J.Molimm.2018.06.247  0.412
2017 Anantharam P, Whitley EM, Mahama B, Kim DS, Sarkar S, Santana C, Chan A, Kanthasamy AG, Kanthasamy A, Boss GR, Rumbeiha WK. Cobinamide is effective for treatment of hydrogen sulfide-induced neurological sequelae in a mouse model. Annals of the New York Academy of Sciences. 1408: 61-78. PMID 29239480 DOI: 10.1111/Nyas.13559  0.721
2017 Sharma S, Carlson S, Puttachary S, Sarkar S, Showman L, Putra M, Kanthasamy AG, Thippeswamy T. Role of the Fyn-PKCδ signaling in SE-induced neuroinflammation and epileptogenesis in experimental models of temporal lobe epilepsy. Neurobiology of Disease. 110: 102-121. PMID 29197620 DOI: 10.1016/J.Nbd.2017.11.008  0.731
2017 Manne S, Kondru N, Nichols T, Lehmkuhl A, Thomsen B, Main R, Halbur P, Dutta S, Kanthasamy AG. Ante-mortem detection of chronic wasting disease in recto-anal mucosa-associated lymphoid tissues from elk (Cervus elaphus nelsoni) using real-time quaking-induced conversion (RT-QuIC) assay: A blinded collaborative study. Prion. 1-16. PMID 29098931 DOI: 10.1080/19336896.2017.1368936  0.308
2017 Sarkar S, Malovic E, Harishchandra DS, Ghaisas S, Panicker N, Charli A, Palanisamy BN, Rokad D, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease. Npj Parkinson's Disease. 3: 30. PMID 29057315 DOI: 10.1038/S41531-017-0032-2  0.828
2017 Xu Q, Langley M, Kanthasamy AG, Reddy MB. Epigallocatechin Gallate Has a Neurorescue Effect in a Mouse Model of Parkinson Disease. The Journal of Nutrition. PMID 28835392 DOI: 10.3945/Jn.117.255034  0.419
2017 R LM, Shivani G, Muhammet A, Jie L, N PB, Huajun J, Vellareddy A, Kanthasamy A, Kanthasamy AG. Manganese exposure exacerbates progressive motor deficits and neurodegeneration in the MitoPark mouse model of Parkinson's disease: Relevance to gene and environment interactions in metal neurotoxicity. Neurotoxicology. PMID 28595911 DOI: 10.1016/J.Neuro.2017.06.002  0.499
2017 Sarkar S, Malovic E, Harischandra DS, Ngwa HA, Ghosh A, Hogan C, Rokad D, Zenitsky G, Jin H, Anantharam V, Kanthasamy AG, Kanthasamy A. Manganese exposure induces neuroinflammation by impairing mitochondrial dynamics in astrocytes. Neurotoxicology. PMID 28539244 DOI: 10.1016/J.Neuro.2017.05.009  0.803
2017 Harischandra DS, Ghaisas S, Rokad D, Kanthasamy AG. Exosomes in Toxicology: Relevance to Chemical Exposure and Pathogenesis of Environmentally Linked Diseases. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 28505322 DOI: 10.1093/Toxsci/Kfx074  0.761
2017 Lawana V, Singh N, Sarkar S, Charli A, Jin H, Anantharam V, Kanthasamy AG, Kanthasamy A. Involvement of c-Abl Kinase in Microglial Activation of NLRP3 Inflammasome and Impairment in Autolysosomal System. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. PMID 28466394 DOI: 10.1007/S11481-017-9746-5  0.774
2017 Harischandra DS, Ghaisas S, Rokad D, Zamanian M, Jin H, Anantharam V, Kimber M, Kanthasamy A, Kanthasamy A. Environmental Neurotoxicant Manganese Regulates Exosome-mediated Extracellular miRNAs in Cell Culture Model of Parkinson's Disease: Relevance to α-Synuclein Misfolding in Metal Neurotoxicity. Neurotoxicology. PMID 28450057 DOI: 10.1016/J.Neuro.2017.04.007  0.782
2017 Sarkar S, Malovic E, Plante B, Zenitsky G, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility. Journal of Visualized Experiments : Jove. PMID 28447995 DOI: 10.3791/55364  0.736
2017 Ay M, Luo J, Langley M, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Molecular Mechanisms Underlying Protective Effects of Quercetin Against Mitochondrial Dysfunction and Progressive Dopaminergic Neurodegeneration in Cell Culture and MitoPark Transgenic Mouse Models of Parkinson's Disease. Journal of Neurochemistry. PMID 28376279 DOI: 10.1111/Jnc.14033  0.573
2017 Langley M, Ghosh A, Charli A, Sarkar S, Ay M, Luo J, Zielonka J, Brenza T, Bennett B, Jin H, Ghaisas S, Schlichtmann B, Kim D, Anantharam V, Kanthasamy A, ... ... Kanthasamy AG, et al. Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice. Antioxidants & Redox Signaling. PMID 28375739 DOI: 10.1089/Ars.2016.6905  0.837
2017 Kondru N, Manne S, Greenlee J, West Greenlee H, Anantharam V, Halbur P, Kanthasamy A, Kanthasamy A. Integrated Organotypic Slice Cultures and RT-QuIC (OSCAR) Assay: Implications for Translational Discovery in Protein Misfolding Diseases. Scientific Reports. 7: 43155. PMID 28233859 DOI: 10.1038/Srep43155  0.345
2016 Rokad D, Ghaisas S, Harischandra DS, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Role of Neurotoxicants and Traumatic Brain Injury in α-Synuclein Protein Misfolding and Aggregation. Brain Research Bulletin. PMID 27993598 DOI: 10.1016/J.Brainresbull.2016.12.003  0.775
2016 Brenza TM, Ghaisas S, Ramirez JE, Harischandra D, Anantharam V, Kalyanaraman B, Kanthasamy AG, Narasimhan B. Neuronal Protection against Oxidative Insult by Polyanhydride Nanoparticle-based Mitochondria-targeted Antioxidant Therapy. Nanomedicine : Nanotechnology, Biology, and Medicine. PMID 27771430 DOI: 10.1016/J.Nano.2016.10.004  0.775
2016 Gordon R, Neal ML, Luo J, Langley MR, Harischandra DS, Panicker N, Charli A, Jin H, Anantharam V, Woodruff TM, Zhou QY, Kanthasamy AG, Kanthasamy A. Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration. Nature Communications. 7: 12932. PMID 27703142 DOI: 10.1038/Ncomms12932  0.839
2016 Zhou QY, Burton KJ, Neal ML, Qiao Y, Kanthasamy AG, Sun Y, Xu X, Ma Y, Li X. Differential arousal regulation by prokineticin 2 signaling in the nocturnal mouse and the diurnal monkey. Molecular Brain. 9: 78. PMID 27535380 DOI: 10.1186/S13041-016-0255-X  0.533
2016 West Greenlee MH, Lind M, Kokemueller R, Mammadova N, Kondru N, Manne S, Smith J, Kanthasamy A, Greenlee J. Temporal Resolution of Misfolded Prion Protein Transport, Accumulation, Glial Activation, and Neuronal Death in the Retinas of Mice Inoculated with Scrapie. The American Journal of Pathology. PMID 27521336 DOI: 10.1016/J.Ajpath.2016.05.018  0.368
2016 Yen CF, Harischandra DS, Kanthasamy A, Sivasankar S. Copper-induced structural conversion templates prion protein oligomerization and neurotoxicity. Science Advances. 2: e1600014. PMID 27419232 DOI: 10.1126/Sciadv.1600014  0.747
2016 Xu Q, Kanthasamy AG, Jin H, Reddy MB. Hepcidin Plays a Key Role in 6-OHDA Induced Iron Overload and Apoptotic Cell Death in a Cell Culture Model of Parkinson's Disease. Parkinson's Disease. 2016: 8684130. PMID 27298749 DOI: 10.1155/2016/8684130  0.449
2016 Gordon R, Singh N, Lawana V, Ghosh A, Harischandra DS, Jin H, Hogan C, Sarkar S, Rokad D, Panicker N, Anantharam V, Kanthasamy AG, Kanthasamy A. Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease. Neurobiology of Disease. PMID 27151770 DOI: 10.1016/J.Nbd.2016.04.008  0.84
2016 Kim DS, Jin H, Anantharam V, Gordon R, Kanthasamy A, Kanthasamy AG. p73 gene in Dopaminergic Neurons is Highly Susceptible to Manganese Neurotoxicity. Neurotoxicology. PMID 27107493 DOI: 10.1016/J.Neuro.2016.04.012  0.413
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin J, Abeliovich H, Arozena AA, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Kanthasamy AG, et al. Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 Autophagy. 12: 443-443. PMID 26902590 DOI: 10.1080/15548627.2016.1147886  0.742
2016 Ghosh A, Langley MR, Harischandra DS, Neal ML, Jin H, Anantharam V, Joseph J, Brenza T, Narasimhan B, Kanthasamy A, Kalyanaraman B, Kanthasamy AG. Mitoapocynin Treatment Protects Against Neuroinflammation and Dopaminergic Neurodegeneration in a Preclinical Animal Model of Parkinson's Disease. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. PMID 26838361 DOI: 10.1007/S11481-016-9650-4  0.854
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Kanthasamy AG, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356  0.778
2016 Gordon R, Albornoz EA, Kumar V, Zhou K, Garin-Michaud A, Mantavani S, Kanthasamy AG, Woodruff TM. Complement C5a activates microglial NLRP3 inflammasomes and drives neurodegeneration in Parkinson's disease through C5aR1 Immunobiology. 221: 1190-1190. DOI: 10.1016/J.Imbio.2016.06.146  0.342
2016 Sivasankar S, Yen C, Harischandra DS, Kanthasamy A. Resolving the Structural Conversion, Aggregation and Neurotoxicity of Prion Proteins at the Single Molecule Level Biophysical Journal. 110: 399a. DOI: 10.1016/J.Bpj.2015.11.2154  0.743
2015 Chen D, Kanthasamy AG, Reddy MB. EGCG Protects against 6-OHDA-Induced Neurotoxicity in a Cell Culture Model. Parkinson's Disease. 2015: 843906. PMID 26770869 DOI: 10.1155/2015/843906  0.45
2015 Ghaisas S, Maher J, Kanthasamy A. Gut microbiome in health and disease: Linking the microbiome-gut-brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases. Pharmacology & Therapeutics. PMID 26627987 DOI: 10.1016/J.Pharmthera.2015.11.012  0.317
2015 Ay M, Jin H, Harischandra DS, Asaithambi A, Kanthasamy A, Anantharam V, Kanthasamy AG. Molecular cloning, epigenetic regulation, and functional characterization of Prkd1 gene promoter in dopaminergic cell culture models of Parkinson's disease. Journal of Neurochemistry. PMID 26230914 DOI: 10.1111/Jnc.13261  0.774
2015 Panicker N, Saminathan H, Jin H, Neal M, Harischandra DS, Gordon R, Kanthasamy K, Lawana V, Sarkar S, Luo J, Anantharam V, Kanthasamy AG, Kanthasamy A. Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 10058-77. PMID 26157004 DOI: 10.1523/Jneurosci.0302-15.2015  0.823
2015 Charli A, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Alterations in mitochondrial dynamics induced by tebufenpyrad and pyridaben in a dopaminergic neuronal cell culture model. Neurotoxicology. PMID 26141520 DOI: 10.1016/J.Neuro.2015.06.007  0.438
2015 Jin H, Kanthasamy A, Harischandra DS, Anantharam V, Rana A, Kanthasamy A. Targeted toxicants to dopaminergic neuronal cell death. Methods in Molecular Biology (Clifton, N.J.). 1254: 239-52. PMID 25431070 DOI: 10.1007/978-1-4939-2152-2_18  0.803
2015 Harischandra DS, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. α-Synuclein protects against manganese neurotoxic insult during the early stages of exposure in a dopaminergic cell model of Parkinson's disease. Toxicological Sciences : An Official Journal of the Society of Toxicology. 143: 454-68. PMID 25416158 DOI: 10.1093/Toxsci/Kfu247  0.778
2015 Sarkar S, Panicker N, Neal M, Jin H, Anantharam V, Kanthasamy A, Kanthasamy A. Pesticide-induced Mitochondrial Dysfunction Augments NLRP3 Inflammasome Signaling Pathway in Primary Microglia The Faseb Journal. 29. DOI: 10.1096/Fasebj.29.1_Supplement.777.5  0.823
2015 Harischandra DS, Lawana V, Rhokad D, Jin H, Anantharam V, Kanthasamy A, Kanthasamy A. Lysosomal dysfunction caused by the environmental neurotoxicant manganese increases exosome-mediated cell-to-cell transfer of α-synuclein by a prion-like mechanism Neurotoxicology and Teratology. 49: 109. DOI: 10.1016/J.Ntt.2015.04.034  0.75
2014 Faburay B, Tark D, Kanthasamy AG, Richt JA. In vitro amplification of scrapie and chronic wasting disease PrP(res) using baculovirus-expressed recombinant PrP as substrate. Prion. 8: 393-403. PMID 25495764 DOI: 10.4161/19336896.2014.983753  0.306
2014 Jin H, Kanthasamy A, Harischandra DS, Kondru N, Ghosh A, Panicker N, Anantharam V, Rana A, Kanthasamy AG. Histone hyperacetylation up-regulates protein kinase Cδ in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of neurodegeneration in Parkinson disease. The Journal of Biological Chemistry. 289: 34743-67. PMID 25342743 DOI: 10.1074/Jbc.M114.576702  0.813
2014 Dranka BP, Gifford A, McAllister D, Zielonka J, Joseph J, O'Hara CL, Stucky CL, Kanthasamy AG, Kalyanaraman B. A novel mitochondrially-targeted apocynin derivative prevents hyposmia and loss of motor function in the leucine-rich repeat kinase 2 (LRRK2(R1441G)) transgenic mouse model of Parkinson's disease. Neuroscience Letters. 583: 159-64. PMID 25263790 DOI: 10.1016/J.Neulet.2014.09.042  0.427
2014 Asaithambi A, Ay M, Jin H, Gosh A, Anantharam V, Kanthasamy A, Kanthasamy AG. Protein kinase D1 (PKD1) phosphorylation promotes dopaminergic neuronal survival during 6-OHDA-induced oxidative stress. Plos One. 9: e96947. PMID 24806360 DOI: 10.1371/Journal.Pone.0096947  0.558
2014 Harischandra DS, Kondru N, Martin DP, Kanthasamy A, Jin H, Anantharam V, Kanthasamy AG. Role of proteolytic activation of protein kinase Cδ in the pathogenesis of prion disease. Prion. 8: 143-53. PMID 24576946 DOI: 10.4161/Pri.28369  0.839
2014 Ngwa HA, Kanthasamy A, Jin H, Anantharam V, Kanthasamy AG. Vanadium exposure induces olfactory dysfunction in an animal model of metal neurotoxicity. Neurotoxicology. 43: 73-81. PMID 24362016 DOI: 10.1016/J.Neuro.2013.12.004  0.428
2014 Jin H, Kanthasamy A, Ghosh A, Anantharam V, Kalyanaraman B, Kanthasamy AG. Mitochondria-targeted antioxidants for treatment of Parkinson's disease: preclinical and clinical outcomes. Biochimica Et Biophysica Acta. 1842: 1282-94. PMID 24060637 DOI: 10.1016/J.Bbadis.2013.09.007  0.752
2014 Jin H, Kanthasamy A, Anantharam V, Kanthasamy AG. Biomarkers of Parkinson's disease Biomarkers in Toxicology. 817-831. DOI: 10.1016/B978-0-12-404630-6.00049-X  0.443
2013 Rana A, Rana B, Mishra R, Sondarva G, Rangasamy V, Das S, Viswakarma N, Kanthasamy A. Mixed Lineage Kinase-c-Jun N-Terminal Kinase Axis: A Potential Therapeutic Target in Cancer. Genes & Cancer. 4: 334-41. PMID 24349631 DOI: 10.1177/1947601913485415  0.353
2013 Ghosh A, Saminathan H, Kanthasamy A, Anantharam V, Jin H, Sondarva G, Harischandra DS, Qian Z, Rana A, Kanthasamy AG. The peptidyl-prolyl isomerase Pin1 up-regulation and proapoptotic function in dopaminergic neurons: relevance to the pathogenesis of Parkinson disease. The Journal of Biological Chemistry. 288: 21955-71. PMID 23754278 DOI: 10.1074/Jbc.M112.444224  0.836
2013 Dranka BP, Gifford A, Ghosh A, Zielonka J, Joseph J, Kanthasamy AG, Kalyanaraman B. Diapocynin prevents early Parkinson's disease symptoms in the leucine-rich repeat kinase 2 (LRRK2R¹⁴⁴¹G) transgenic mouse. Neuroscience Letters. 549: 57-62. PMID 23721786 DOI: 10.1016/J.Neulet.2013.05.034  0.78
2012 Ghosh A, Kanthasamy A, Joseph J, Anantharam V, Srivastava P, Dranka BP, Kalyanaraman B, Kanthasamy AG. Anti-inflammatory and neuroprotective effects of an orally active apocynin derivative in pre-clinical models of Parkinson's disease. Journal of Neuroinflammation. 9: 241. PMID 23092448 DOI: 10.1186/1742-2094-9-241  0.803
2012 Chandramani Shivalingappa P, Jin H, Anantharam V, Kanthasamy A, Kanthasamy A. N-Acetyl Cysteine Protects against Methamphetamine-Induced Dopaminergic Neurodegeneration via Modulation of Redox Status and Autophagy in Dopaminergic Cells. Parkinson's Disease. 2012: 424285. PMID 23056996 DOI: 10.1155/2012/424285  0.473
2012 Kanthasamy AG, Choi C, Jin H, Harischandra DS, Anantharam V, Kanthasamy A. Effect of divalent metals on the neuronal proteasomal system, prion protein ubiquitination and aggregation. Toxicology Letters. 214: 288-95. PMID 22995398 DOI: 10.1016/J.Toxlet.2012.09.008  0.805
2012 Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... ... Kanthasamy AG, ... ... Kanthasamy A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490 DOI: 10.4161/Auto.19496  0.302
2012 Dranka BP, Zielonka J, Kanthasamy AG, Kalyanaraman B. Alterations in bioenergetic function induced by Parkinson's disease mimetic compounds: lack of correlation with superoxide generation. Journal of Neurochemistry. 122: 941-51. PMID 22708893 DOI: 10.1111/J.1471-4159.2012.07836.X  0.497
2012 Rangasamy V, Mishra R, Sondarva G, Das S, Lee TH, Bakowska JC, Tzivion G, Malter JS, Rana B, Lu KP, Kanthasamy A, Rana A. Mixed-lineage kinase 3 phosphorylates prolyl-isomerase Pin1 to regulate its nuclear translocation and cellular function. Proceedings of the National Academy of Sciences of the United States of America. 109: 8149-54. PMID 22566623 DOI: 10.1073/Pnas.1200804109  0.365
2012 Gordon R, Anantharam V, Kanthasamy AG, Kanthasamy A. Proteolytic activation of proapoptotic kinase protein kinase Cδ by tumor necrosis factor α death receptor signaling in dopaminergic neurons during neuroinflammation. Journal of Neuroinflammation. 9: 82. PMID 22540228 DOI: 10.1186/1742-2094-9-82  0.539
2012 Shin EJ, Duong CX, Nguyen XK, Li Z, Bing G, Bach JH, Park DH, Nakayama K, Ali SF, Kanthasamy AG, Cadet JL, Nabeshima T, Kim HC. Role of oxidative stress in methamphetamine-induced dopaminergic toxicity mediated by protein kinase Cδ. Behavioural Brain Research. 232: 98-113. PMID 22512859 DOI: 10.1016/J.Bbr.2012.04.001  0.428
2012 Lin M, Chandramani-Shivalingappa P, Jin H, Ghosh A, Anantharam V, Ali S, Kanthasamy AG, Kanthasamy A. Methamphetamine-induced neurotoxicity linked to ubiquitin-proteasome system dysfunction and autophagy-related changes that can be modulated by protein kinase C delta in dopaminergic neuronal cells. Neuroscience. 210: 308-32. PMID 22445524 DOI: 10.1016/J.Neuroscience.2012.03.004  0.792
2012 Wong DM, Ghosh A, Fales-Williams AJ, Haynes JS, Kanthasamy AG. Evidence of oxidative injury of the spinal cord in 2 horses with equine degenerative myeloencephalopathy. Veterinary Pathology. 49: 1049-53. PMID 22390882 DOI: 10.1177/0300985812439074  0.673
2012 Kanthasamy A, Jin H, Anantharam V, Sondarva G, Rangasamy V, Rana A, Kanthasamy A. Emerging neurotoxic mechanisms in environmental factors-induced neurodegeneration. Neurotoxicology. 33: 833-7. PMID 22342404 DOI: 10.1016/J.Neuro.2012.01.011  0.492
2012 Dranka BP, Gifford A, Ghosh A, Kanthasamy AG, Kalyanaraman B. The NADPH Oxidase Inhibitor Diapocynin Prevents Parkinson’s Disease Symptoms in the Leucine-Rich Repeat Kinase 2 (LRRK2R1441G) Transgenic Mouse Free Radical Biology and Medicine. 53: S64. DOI: 10.1016/J.Freeradbiomed.2012.10.194  0.726
2011 Kanthasamy K, Gordon R, Jin H, Anantharam V, Ali S, Kanthasamy AG, Kanthasamy A. Neuroprotective effect of resveratrol against methamphetamine-induced dopaminergic apoptotic cell death in a cell culture model of neurotoxicity. Current Neuropharmacology. 9: 49-53. PMID 21886561 DOI: 10.2174/157015911795017353  0.487
2011 Martin DP, Anantharam V, Jin H, Witte T, Houk R, Kanthasamy A, Kanthasamy AG. Infectious prion protein alters manganese transport and neurotoxicity in a cell culture model of prion disease. Neurotoxicology. 32: 554-62. PMID 21871919 DOI: 10.1016/J.Neuro.2011.07.008  0.674
2011 Afeseh Ngwa H, Kanthasamy A, Gu Y, Fang N, Anantharam V, Kanthasamy AG. Manganese nanoparticle activates mitochondrial dependent apoptotic signaling and autophagy in dopaminergic neuronal cells. Toxicology and Applied Pharmacology. 256: 227-40. PMID 21856324 DOI: 10.1016/J.Taap.2011.07.018  0.786
2011 Latchoumycandane C, Anantharam V, Jin H, Kanthasamy A, Kanthasamy A. Dopaminergic neurotoxicant 6-OHDA induces oxidative damage through proteolytic activation of PKCδ in cell culture and animal models of Parkinson's disease. Toxicology and Applied Pharmacology. 256: 314-23. PMID 21846476 DOI: 10.1016/J.Taap.2011.07.021  0.584
2011 Sun F, Kanthasamy AG, Kanthasamy A. Measurement of proteasomal dysfunction in cell models of dopaminergic degeneration. Methods in Molecular Biology (Clifton, N.J.). 758: 293-305. PMID 21815074 DOI: 10.1007/978-1-61779-170-3_20  0.836
2011 Saminathan H, Asaithambi A, Anantharam V, Kanthasamy AG, Kanthasamy A. Environmental neurotoxic pesticide dieldrin activates a non receptor tyrosine kinase to promote PKCδ-mediated dopaminergic apoptosis in a dopaminergic neuronal cell model. Neurotoxicology. 32: 567-77. PMID 21801747 DOI: 10.1016/J.Neuro.2011.06.009  0.835
2011 Song C, Kanthasamy A, Jin H, Anantharam V, Kanthasamy AG. Paraquat induces epigenetic changes by promoting histone acetylation in cell culture models of dopaminergic degeneration. Neurotoxicology. 32: 586-95. PMID 21777615 DOI: 10.1016/J.Neuro.2011.05.018  0.787
2011 Asaithambi A, Kanthasamy A, Saminathan H, Anantharam V, Kanthasamy AG. Protein kinase D1 (PKD1) activation mediates a compensatory protective response during early stages of oxidative stress-induced neuronal degeneration. Molecular Neurodegeneration. 6: 43. PMID 21696630 DOI: 10.1186/1750-1326-6-43  0.839
2011 Shin EJ, Duong CX, Nguyen TX, Bing G, Bach JH, Park DH, Nakayama K, Ali SF, Kanthasamy AG, Cadet JL, Nabeshima T, Kim HC. PKCδ inhibition enhances tyrosine hydroxylase phosphorylation in mice after methamphetamine treatment. Neurochemistry International. 59: 39-50. PMID 21672585 DOI: 10.1016/J.Neuint.2011.03.022  0.39
2011 Jin H, Kanthasamy A, Anantharam V, Rana A, Kanthasamy AG. Transcriptional regulation of pro-apoptotic protein kinase Cdelta: implications for oxidative stress-induced neuronal cell death. The Journal of Biological Chemistry. 286: 19840-59. PMID 21467032 DOI: 10.1074/Jbc.M110.203687  0.417
2011 Xu Q, Kanthasamy AG, Reddy MB. Phytic Acid Protects against 6-Hydroxydopamine-Induced Dopaminergic Neuron Apoptosis in Normal and Iron Excess Conditions in a Cell Culture Model. Parkinson's Disease. 2011: 431068. PMID 21331377 DOI: 10.4061/2011/431068  0.416
2011 Zhang D, Kanthasamy A, Anantharam V, Kanthasamy A. Effects of manganese on tyrosine hydroxylase (TH) activity and TH-phosphorylation in a dopaminergic neural cell line. Toxicology and Applied Pharmacology. 254: 65-71. PMID 21310168 DOI: 10.1016/J.Taap.2010.03.023  0.657
2011 Jin H, Kanthasamy A, Ghosh A, Yang Y, Anantharam V, Kanthasamy AG. α-Synuclein negatively regulates protein kinase Cδ expression to suppress apoptosis in dopaminergic neurons by reducing p300 histone acetyltransferase activity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 2035-51. PMID 21307242 DOI: 10.1523/Jneurosci.5634-10.2011  0.817
2011 Gordon R, Hogan CE, Neal ML, Anantharam V, Kanthasamy AG, Kanthasamy A. A simple magnetic separation method for high-yield isolation of pure primary microglia. Journal of Neuroscience Methods. 194: 287-96. PMID 21074565 DOI: 10.1016/J.Jneumeth.2010.11.001  0.564
2011 Kanthasamy AG, Ghosh A, Kanthasamy A, Joseph J, Anantharam V, Kalyanaraman B. Anti-neuroinflammatory Effect of a Novel Compound Mito-apocynin in a Mouse Model of Parkinson's Disease Free Radical Biology and Medicine. 51: S89. DOI: 10.1016/J.Freeradbiomed.2011.10.409  0.731
2010 Ghosh A, Chandran K, Kalivendi SV, Joseph J, Antholine WE, Hillard CJ, Kanthasamy A, Kanthasamy A, Kalyanaraman B. Neuroprotection by a mitochondria-targeted drug in a Parkinson's disease model. Free Radical Biology & Medicine. 49: 1674-84. PMID 20828611 DOI: 10.1016/J.Freeradbiomed.2010.08.028  0.793
2010 Choi CJ, Anantharam V, Martin DP, Nicholson EM, Richt JA, Kanthasamy A, Kanthasamy AG. Manganese upregulates cellular prion protein and contributes to altered stabilization and proteolysis: relevance to role of metals in pathogenesis of prion disease. Toxicological Sciences : An Official Journal of the Society of Toxicology. 115: 535-46. PMID 20176619 DOI: 10.1093/Toxsci/Kfq049  0.748
2010 Song C, Kanthasamy A, Anantharam V, Sun F, Kanthasamy AG. Environmental neurotoxic pesticide increases histone acetylation to promote apoptosis in dopaminergic neuronal cells: relevance to epigenetic mechanisms of neurodegeneration. Molecular Pharmacology. 77: 621-32. PMID 20097775 DOI: 10.1124/Mol.109.062174  0.83
2010 Kanthasamy A, Jin H, Mehrotra S, Mishra R, Kanthasamy A, Rana A. Novel cell death signaling pathways in neurotoxicity models of dopaminergic degeneration: relevance to oxidative stress and neuroinflammation in Parkinson's disease. Neurotoxicology. 31: 555-61. PMID 20005250 DOI: 10.1016/J.Neuro.2009.12.003  0.533
2010 Mishra R, Sondarva G, Kanthasamy A, Rana B, Rana A. Abstract 5065: Phosphorylation of Peptidyl prolyl isomerase 1 by Mixed Lineage Kinase 3 promotes breast cancer pathogenesis Cancer Research. 70: 5065-5065. DOI: 10.1158/1538-7445.Am10-5065  0.319
2010 Kanthasamy AG, Ghosh A, Joseph J, Hogan C, Anantharam V, Kanthasamy A, Kalyanaraman B. Novel NOX2 Inhibitor Suppresses Neuroinflammation in Experimental Models of Parkinson's Disease: A New Translational Strategy in Neuroprotection Free Radical Biology and Medicine. 49: S186. DOI: 10.1016/J.Freeradbiomed.2010.10.532  0.746
2010 Dranka BP, Zielonka J, Kanthasamy AG, Kalyanaraman B. Bioenergetic Remodeling Induced by 1-methyl-4-phenylpyridinium (MPP+) in Dopaminergic N27 cells: Implications for Parkinson’s Disease Free Radical Biology and Medicine. 49: S154-S155. DOI: 10.1016/J.Freeradbiomed.2010.10.434  0.389
2009 Ortiz-Ortiz MA, Morán JM, Bravosanpedro JM, González-Polo RA, Niso-Santano M, Anantharam V, Kanthasamy AG, Soler G, Fuentes JM. Curcumin enhances paraquat-induced apoptosis of N27 mesencephalic cells via the generation of reactive oxygen species. Neurotoxicology. 30: 1008-18. PMID 19660496 DOI: 10.1016/J.Neuro.2009.07.016  0.477
2009 Afeseh Ngwa H, Kanthasamy A, Anantharam V, Song C, Witte T, Houk R, Kanthasamy AG. Vanadium induces dopaminergic neurotoxicity via protein kinase Cdelta dependent oxidative signaling mechanisms: relevance to etiopathogenesis of Parkinson's disease. Toxicology and Applied Pharmacology. 240: 273-85. PMID 19646462 DOI: 10.1016/J.Taap.2009.07.025  0.841
2009 Sun F, Kanthasamy A, Anantharam V, Kanthasamy AG. Mitochondrial accumulation of polyubiquitinated proteins and differential regulation of apoptosis by polyubiquitination sites Lys-48 and -63. Journal of Cellular and Molecular Medicine. 13: 1632-43. PMID 19432818 DOI: 10.1111/J.1582-4934.2009.00775.X  0.844
2008 Carvour M, Song C, Kaul S, Anantharam V, Kanthasamy A, Kanthasamy A. Chronic low-dose oxidative stress induces caspase-3-dependent PKCdelta proteolytic activation and apoptosis in a cell culture model of dopaminergic neurodegeneration. Annals of the New York Academy of Sciences. 1139: 197-205. PMID 18991865 DOI: 10.1196/Annals.1432.020  0.814
2008 Kanthasamy AG, Kitazawa M, Yang Y, Anantharam V, Kanthasamy A. Environmental neurotoxin dieldrin induces apoptosis via caspase-3-dependent proteolytic activation of protein kinase C delta (PKCdelta): Implications for neurodegeneration in Parkinson's disease. Molecular Brain. 1: 12. PMID 18945348 DOI: 10.1186/1756-6606-1-12  0.773
2008 Anantharam V, Kanthasamy A, Choi CJ, Martin DP, Latchoumycandane C, Richt JA, Kanthasamy AG. Opposing roles of prion protein in oxidative stress- and ER stress-induced apoptotic signaling. Free Radical Biology & Medicine. 45: 1530-41. PMID 18835352 DOI: 10.1016/J.Freeradbiomed.2008.08.028  0.77
2008 Sun F, Kanthasamy A, Song C, Yang Y, Anantharam V, Kanthasamy AG. Proteasome inhibitor-induced apoptosis is mediated by positive feedback amplification of PKCdelta proteolytic activation and mitochondrial translocation. Journal of Cellular and Molecular Medicine. 12: 2467-81. PMID 18298651 DOI: 10.1111/J.1582-4934.2008.00293.X  0.834
2008 Xu Q, Kanthasamy AG, Reddy MB. Neuroprotective effect of the natural iron chelator, phytic acid in a cell culture model of Parkinson's disease. Toxicology. 245: 101-8. PMID 18255213 DOI: 10.1016/J.Tox.2007.12.017  0.427
2008 Reddy MB, Xu Q, Zhou Y, Kanthasamy AG. Neuroprotective Effect of Green Tea Polyphenol, EGCG in Animal Model of Parkinson's Disease The Faseb Journal. 22: 677-677. DOI: 10.1096/Fasebj.22.2_Supplement.677  0.381
2008 Kanthasamy A, Kitazawa M, Kaul S, Anantharam SV, Kanthasamy AG. A novel oxidative stress dependent apoptotic pathway in pesticide-induced dopaminergic degeneration in PD models Journal of Neurochemistry. 81: 76-76. DOI: 10.1046/J.1471-4159.81.S1.44_3.X  0.718
2007 Anantharam V, Kaul S, Song C, Kanthasamy A, Kanthasamy AG. Pharmacological inhibition of neuronal NADPH oxidase protects against 1-methyl-4-phenylpyridinium (MPP+)-induced oxidative stress and apoptosis in mesencephalic dopaminergic neuronal cells. Neurotoxicology. 28: 988-97. PMID 17904225 DOI: 10.1016/J.Neuro.2007.08.008  0.838
2007 Zhang D, Anantharam V, Kanthasamy A, Kanthasamy AG. Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease. The Journal of Pharmacology and Experimental Therapeutics. 322: 913-22. PMID 17565007 DOI: 10.1124/Jpet.107.124669  0.718
2007 Sun F, Kanthasamy A, Anantharam V, Kanthasamy AG. Environmental neurotoxic chemicals-induced ubiquitin proteasome system dysfunction in the pathogenesis and progression of Parkinson's disease. Pharmacology & Therapeutics. 114: 327-44. PMID 17521740 DOI: 10.1016/J.Pharmthera.2007.04.001  0.842
2007 Zhang D, Kanthasamy A, Yang Y, Anantharam V, Kanthasamy A. Protein kinase C delta negatively regulates tyrosine hydroxylase activity and dopamine synthesis by enhancing protein phosphatase-2A activity in dopaminergic neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 5349-62. PMID 17507557 DOI: 10.1523/Jneurosci.4107-06.2007  0.709
2007 Choi CJ, Anantharam V, Saetveit NJ, Houk RS, Kanthasamy A, Kanthasamy AG. Normal cellular prion protein protects against manganese-induced oxidative stress and apoptotic cell death. Toxicological Sciences : An Official Journal of the Society of Toxicology. 98: 495-509. PMID 17483122 DOI: 10.1093/Toxsci/Kfm099  0.67
2007 Anantharam V, Lehrmann E, Kanthasamy A, Yang Y, Banerjee P, Becker KG, Freed WJ, Kanthasamy AG. Microarray analysis of oxidative stress regulated genes in mesencephalic dopaminergic neuronal cells: relevance to oxidative damage in Parkinson's disease. Neurochemistry International. 50: 834-47. PMID 17397968 DOI: 10.1016/J.Neuint.2007.02.003  0.655
2006 Kanthasamy A, Anantharam V, Ali SF, Kanthasamy AG. Methamphetamine induces autophagy and apoptosis in a mesencephalic dopaminergic neuronal culture model: role of cathepsin-D in methamphetamine-induced apoptotic cell death. Annals of the New York Academy of Sciences. 1074: 234-44. PMID 17105920 DOI: 10.1196/Annals.1369.022  0.474
2006 Kanthasamy AG, Anantharam V, Zhang D, Latchoumycandane C, Jin H, Kaul S, Kanthasamy A. A novel peptide inhibitor targeted to caspase-3 cleavage site of a proapoptotic kinase protein kinase C delta (PKCdelta) protects against dopaminergic neuronal degeneration in Parkinson's disease models. Free Radical Biology & Medicine. 41: 1578-89. PMID 17045926 DOI: 10.1016/J.Freeradbiomed.2006.08.016  0.76
2006 Sun F, Anantharam V, Zhang D, Latchoumycandane C, Kanthasamy A, Kanthasamy AG. Proteasome inhibitor MG-132 induces dopaminergic degeneration in cell culture and animal models. Neurotoxicology. 27: 807-15. PMID 16870259 DOI: 10.1016/J.Neuro.2006.06.006  0.832
2006 Choi CJ, Kanthasamy A, Anantharam V, Kanthasamy AG. Interaction of metals with prion protein: possible role of divalent cations in the pathogenesis of prion diseases. Neurotoxicology. 27: 777-87. PMID 16860868 DOI: 10.1016/J.Neuro.2006.06.004  0.625
2005 Kanthasamy AG, Kitazawa M, Kanthasamy A, Anantharam V. Dieldrin-induced neurotoxicity: relevance to Parkinson's disease pathogenesis. Neurotoxicology. 26: 701-19. PMID 16112328 DOI: 10.1016/J.Neuro.2004.07.010  0.667
2005 Sun F, Anantharam V, Latchoumycandane C, Kanthasamy A, Kanthasamy AG. Dieldrin induces ubiquitin-proteasome dysfunction in alpha-synuclein overexpressing dopaminergic neuronal cells and enhances susceptibility to apoptotic cell death. The Journal of Pharmacology and Experimental Therapeutics. 315: 69-79. PMID 15987830 DOI: 10.1124/Jpet.105.084632  0.823
2005 Kaul S, Anantharam V, Kanthasamy A, Kanthasamy AG. Wild-type alpha-synuclein interacts with pro-apoptotic proteins PKCdelta and BAD to protect dopaminergic neuronal cells against MPP+-induced apoptotic cell death. Brain Research. Molecular Brain Research. 139: 137-52. PMID 15978696 DOI: 10.1016/J.Molbrainres.2005.05.022  0.61
2005 Kaul S, Anantharam V, Yang Y, Choi CJ, Kanthasamy A, Kanthasamy AG. Tyrosine phosphorylation regulates the proteolytic activation of protein kinase Cdelta in dopaminergic neuronal cells. The Journal of Biological Chemistry. 280: 28721-30. PMID 15961393 DOI: 10.1074/Jbc.M501092200  0.812
2005 Latchoumycandane C, Anantharam V, Kitazawa M, Yang Y, Kanthasamy A, Kanthasamy AG. Protein kinase Cdelta is a key downstream mediator of manganese-induced apoptosis in dopaminergic neuronal cells. The Journal of Pharmacology and Experimental Therapeutics. 313: 46-55. PMID 15608081 DOI: 10.1124/Jpet.104.078469  0.754
2005 Kitazawa M, Anantharam V, Yang Y, Hirata Y, Kanthasamy A, Kanthasamy AG. Activation of protein kinase C delta by proteolytic cleavage contributes to manganese-induced apoptosis in dopaminergic cells: protective role of Bcl-2. Biochemical Pharmacology. 69: 133-46. PMID 15588722 DOI: 10.1016/J.Bcp.2004.08.035  0.737
2004 Anantharam V, Kitazawa M, Latchoumycandane C, Kanthasamy A, Kanthasamy AG. Blockade of PKCdelta proteolytic activation by loss of function mutants rescues mesencephalic dopaminergic neurons from methylcyclopentadienyl manganese tricarbonyl (MMT)-induced apoptotic cell death. Annals of the New York Academy of Sciences. 1035: 271-89. PMID 15681813 DOI: 10.1196/Annals.1332.017  0.693
2004 Kitazawa M, Anantharam V, Kanthasamy A, Kanthasamy AG. Dieldrin promotes proteolytic cleavage of poly(ADP-ribose) polymerase and apoptosis in dopaminergic cells: protective effect of mitochondrial anti-apoptotic protein Bcl-2. Neurotoxicology. 25: 589-98. PMID 15183012 DOI: 10.1016/J.Neuro.2003.09.014  0.641
2004 Yang Y, Kaul S, Zhang D, Anantharam V, Kanthasamy AG. Suppression of caspase-3-dependent proteolytic activation of protein kinase C delta by small interfering RNA prevents MPP+-induced dopaminergic degeneration. Molecular and Cellular Neurosciences. 25: 406-21. PMID 15033169 DOI: 10.1016/J.Mcn.2003.11.011  0.805
2003 Kanthasamy AG, Kitazawa M, Kaul S, Yang Y, Lahiri DK, Anantharam V, Kanthasamy A. Proteolytic activation of proapoptotic kinase PKCdelta is regulated by overexpression of Bcl-2: implications for oxidative stress and environmental factors in Parkinson's disease. Annals of the New York Academy of Sciences. 1010: 683-6. PMID 15033812 DOI: 10.1196/Annals.1299.125  0.809
2003 Kanthasamy AG, Kitazawa M, Kanthasamy A, Anantharam V. Role of proteolytic activation of protein kinase Cdelta in oxidative stress-induced apoptosis. Antioxidants & Redox Signaling. 5: 609-20. PMID 14580317 DOI: 10.1089/152308603770310275  0.654
2003 Kaul S, Kanthasamy A, Kitazawa M, Anantharam V, Kanthasamy AG. Caspase-3 dependent proteolytic activation of protein kinase C delta mediates and regulates 1-methyl-4-phenylpyridinium (MPP+)-induced apoptotic cell death in dopaminergic cells: relevance to oxidative stress in dopaminergic degeneration. The European Journal of Neuroscience. 18: 1387-401. PMID 14511319 DOI: 10.1046/J.1460-9568.2003.02864.X  0.731
2003 Kitazawa M, Anantharam V, Kanthasamy AG. Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cdelta in dopaminergic cells: relevance to oxidative stress and dopaminergic degeneration. Neuroscience. 119: 945-64. PMID 12831855 DOI: 10.1016/S0306-4522(03)00226-4  0.619
2003 Madhavan L, Freed WJ, Anantharam V, Kanthasamy AG. 5-hydroxytryptamine 1A receptor activation protects against N-methyl-D-aspartate-induced apoptotic cell death in striatal and mesencephalic cultures. The Journal of Pharmacology and Experimental Therapeutics. 304: 913-23. PMID 12604665 DOI: 10.1124/Jpet.102.044370  0.43
2002 Kitazawa M, Wagner JR, Kirby ML, Anantharam V, Kanthasamy AG. Oxidative stress and mitochondrial-mediated apoptosis in dopaminergic cells exposed to methylcyclopentadienyl manganese tricarbonyl. The Journal of Pharmacology and Experimental Therapeutics. 302: 26-35. PMID 12065696 DOI: 10.1124/Jpet.302.1.26  0.646
2002 Anantharam V, Kitazawa M, Wagner J, Kaul S, Kanthasamy AG. Caspase-3-dependent proteolytic cleavage of protein kinase Cdelta is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 1738-51. PMID 11880503 DOI: 10.1523/Jneurosci.22-05-01738.2002  0.723
2001 Kitazawa M, Anantharam V, Kanthasamy AG. Dieldrin-induced oxidative stress and neurochemical changes contribute to apoptopic cell death in dopaminergic cells. Free Radical Biology & Medicine. 31: 1473-85. PMID 11728820 DOI: 10.1016/S0891-5849(01)00726-2  0.652
2000 Kanthasamy AG, Nguyen BQ, Truong DD. Animal model of posthypoxic myoclonus: II. Neurochemical, pathologic, and pharmacologic characterization. Movement Disorders : Official Journal of the Movement Disorder Society. 15: 31-8. PMID 10755270 DOI: 10.1002/Mds.870150707  0.319
1997 Kanthasamy AG, Ardelt B, Malave A, Mills EM, Powley TL, Borowitz JL, Isom GE. Reactive oxygen species generated by cyanide mediate toxicity in rat pheochromocytoma cells. Toxicology Letters. 93: 47-54. PMID 9381482 DOI: 10.1016/S0378-4274(97)00068-4  0.403
1997 Kanthasamy AG, Kanthasamy A, Matsumoto RR, Vu TQ, Truong DD. Neuroprotective effects of the strychnine-insensitive glycine site NMDA antagonist (R)-HA-966 in an experimental model of Parkinson's disease. Brain Research. 759: 1-8. PMID 9219856 DOI: 10.1016/S0006-8993(96)01192-4  0.41
1995 Kanthasamy AG, Matsumoto RR, Gunasekar PG, Trunong DD. Excitoprotective effect of felbamate in cultured cortical neurons. Brain Research. 705: 97-104. PMID 8821739 DOI: 10.1016/0006-8993(95)01147-1  0.342
1995 Gunasekar PG, Kanthasamy AG, Borowitz JL, Isom GE. Monitoring intracellular nitric oxide formation by dichlorofluorescin in neuronal cells Journal of Neuroscience Methods. 61: 15-21. PMID 8618413 DOI: 10.1016/0165-0270(95)00018-P  0.333
1995 Pavlaković G, Kane MD, Eyer CL, Kanthasamy A, Isom GE. Activation of protein kinase C by trimethyltin: relevance to neurotoxicity. Journal of Neurochemistry. 65: 2338-43. PMID 7595523 DOI: 10.1046/J.1471-4159.1995.65052338.X  0.422
1994 Borowitz JL, Rathinavelu A, Kanthasamy A, Wilsbacher J, Isom GE. Accumulation of Labeled Cyanide in Neuronal Tissue Toxicology and Applied Pharmacology. 129: 80-85. PMID 7974498 DOI: 10.1006/Taap.1994.1230  0.327
1994 Kanthasamy AG, Borowitz JL, Pavlakovic G, Isom GE. Dopaminergic neurotoxicity of cyanide: Neurochemical, histological, and behavioral characterization Toxicology and Applied Pharmacology. 126: 156-163. PMID 7910421 DOI: 10.1006/Taap.1994.1102  0.363
1993 Borowitz JL, Kanthasamy AG, Mitchell PJ, Isom GE. Use of PC12 Cells as a Neurotoxicological Screen: Characterization of Anticyanide Compounds Toxicological Sciences. 20: 133-140. PMID 8095480 DOI: 10.1006/Faat.1993.1018  0.307
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