Anumantha G. Kanthasamy - Publications

Affiliations: 
Neuroscience Iowa State University, Ames, IA, United States 
Area:
Neuroscience, Toxicology

119 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Schlichtmann BW, Kondru N, Hepker MM, Kanthasamy AG, Anantharam V, John M, Ban B, Mallapragada SK, Narasimhan B. Enzyme Immunoassay-Based Platform for Accurate Detection of Serum Pathological α-Synuclein in Parkinson's Disease Patients. Acs Chemical Neuroscience. PMID 33196164 DOI: 10.1021/acschemneuro.0c00461  0.96
2020 Manne S, Kondru N, Jin H, Serrano GE, Anantharam V, Kanthasamy A, Adler CH, Beach TG, Kanthasamy AG. Blinded RT-QuIC Analysis of α-Synuclein Biomarker in Skin Tissue from Parkinson's Disease Patients. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 32960470 DOI: 10.1002/mds.28242  0.96
2020 Samidurai M, Tarale P, Janarthanam C, Estrada CG, Gordon R, Zenitsky G, Jin H, Anantharam V, Kanthasamy AG, Kanthasamy A. Tumor Necrosis Factor-Like Weak Inducer of Apoptosis (TWEAK) Enhances Activation of STAT3/NLRC4 Inflammasome Signaling Axis through PKCδ in Astrocytes: Implications for Parkinson's Disease. Cells. 9. PMID 32759670 DOI: 10.3390/cells9081831  0.96
2020 Sarkar S, Nguyen HM, Malovic E, Luo J, Langley M, Palanisamy BN, Singh N, Manne S, Neal M, Gabrielle M, Abdalla A, Anantharam P, Rokad D, Panicker N, Singh V, ... ... Kanthasamy AG, et al. Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson's disease. The Journal of Clinical Investigation. PMID 32597830 DOI: 10.1172/JCI136174  0.96
2020 Saminathan H, Charli A, Luo J, Panicker N, Gordon R, Hostetter JM, Jin H, Anantharam V, Kanthasamy AG, Kanthasamy A. Fyn kinase mediates pro-inflammatory response in a mouse model of endotoxemia: Relevance to translational research. European Journal of Pharmacology. 173259. PMID 32565338 DOI: 10.1016/j.ejphar.2020.173259  0.96
2020 Kondru N, Manne S, Kokemuller R, Greenlee J, Greenlee MHW, Nichols T, Kong Q, Anantharam V, Kanthasamy A, Halbur P, Kanthasamy AG. An Ex Vivo Brain Slice Culture Model of Chronic Wasting Disease: Implications for Disease Pathogenesis and Therapeutic Development. Scientific Reports. 10: 7640. PMID 32376941 DOI: 10.1038/s41598-020-64456-9  0.96
2020 Harper MM, Rudd D, Meyer KJ, Kanthasamy AG, Anantharam V, Pieper AA, Vázquez-Rosa E, Shin MK, Chaubey K, Koh Y, Evans LP, Bassuk AG, Anderson MG, Dutca L, Kudva IT, et al. Identification of chronic brain protein changes and protein targets of serum auto-antibodies after blast-mediated traumatic brain injury. Heliyon. 6: e03374. PMID 32099918 DOI: 10.1016/j.heliyon.2020.e03374  0.96
2020 Sarkar S, Dammer EB, Malovic E, Olsen AL, Raza SA, Gao T, Xiao H, Oliver DL, Duong D, Joers V, Seyfried N, Huang M, Kukar T, Tansey MG, Kanthasamy AG, et al. Molecular Signatures of Neuroinflammation Induced by αSynuclein Aggregates in Microglial Cells. Frontiers in Immunology. 11: 33. PMID 32082315 DOI: 10.3389/fimmu.2020.00033  0.68
2019 Manne S, Kondru N, Jin H, Anantharam V, Huang X, Kanthasamy A, Kanthasamy AG. α-Synuclein real-time quaking-induced conversion in the submandibular glands of Parkinson's disease patients. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 31758740 DOI: 10.1002/mds.27907  0.96
2019 Ghaisas S, Langley MR, Palanisamy BN, Dutta S, Narayanaswamy K, Plummer PJ, Sarkar S, Ay M, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. MitoPark Transgenic Mouse Model Recapitulates the Gastrointestinal Dysfunction and Gut-Microbiome Changes of Parkinson's Disease. Neurotoxicology. PMID 31505196 DOI: 10.1016/j.neuro.2019.09.004  0.96
2019 Panicker N, Kanthasamy A, Kanthasamy AG. Fyn amplifies NLRP3 inflammasome signaling in Parkinson's disease. Aging. PMID 31454793 DOI: 10.18632/aging.102210  0.76
2019 Harischandra DS, Rokad D, Ghaisas S, Verma S, Robertson A, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Enhanced differentiation of human dopaminergic neuronal cell model for preclinical translational research in Parkinson's disease. Biochimica Et Biophysica Acta. Molecular Basis of Disease. 165533. PMID 31442530 DOI: 10.1016/j.bbadis.2019.165533  0.96
2019 Harischandra DS, Ghaisas S, Zenitsky G, Jin H, Kanthasamy A, Anantharam V, Kanthasamy AG. Manganese-Induced Neurotoxicity: New Insights Into the Triad of Protein Misfolding, Mitochondrial Impairment, and Neuroinflammation. Frontiers in Neuroscience. 13: 654. PMID 31293375 DOI: 10.3389/fnins.2019.00654  0.96
2019 Richardson JR, Fitsanakis V, Westerink RHS, Kanthasamy AG. Neurotoxicity of pesticides. Acta Neuropathologica. PMID 31197504 DOI: 10.1007/s00401-019-02033-9  0.44
2019 Rokad D, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Exosomes as Mediators of Chemical-Induced Toxicity. Current Environmental Health Reports. PMID 31102182 DOI: 10.1007/s40572-019-00233-9  0.96
2019 Panicker N, Sarkar S, Harischandra DS, Neal M, Kam TI, Jin H, Saminathan H, Langley M, Charli A, Samidurai M, Rokad D, Ghaisas S, Pletnikova O, Dawson VL, Dawson TM, ... ... Kanthasamy AG, ... ... Kanthasamy A, et al. Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia. The Journal of Experimental Medicine. PMID 31036561 DOI: 10.1084/jem.20182191  0.96
2019 Xu Q, Kanthasamy AG, Reddy MB. Epigallocatechin Gallate Protects against TNFα- or HO- Induced Apoptosis by Modulating Iron Related Proteins in a Cell Culture Model. International Journal For Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition. 1-8. PMID 30961459 DOI: 10.1024/0300-9831/a000493  0.6
2019 Luo J, Padhi P, Jin H, Anantharam V, Zenitsky G, Wang Q, Willette AA, Kanthasamy A, Kanthasamy AG. Utilization of the CRISPR-Cas9 Gene Editing System to Dissect Neuroinflammatory and Neuropharmacological Mechanisms in Parkinson's Disease. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. PMID 30879240 DOI: 10.1007/s11481-019-09844-3  0.96
2019 Harischandra DS, Rokad D, Neal ML, Ghaisas S, Manne S, Sarkar S, Panicker N, Zenitsky G, Jin H, Lewis M, Huang X, Anantharam V, Kanthasamy A, Kanthasamy AG. Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein. Science Signaling. 12. PMID 30862700 DOI: 10.1126/scisignal.aau4543  0.96
2019 Song C, Charli A, Luo J, Riaz Z, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Mechanistic Interplay between Autophagy and Apoptotic Signaling in Endosulfan-induced Dopaminergic Neurotoxicity: Relevance to the Adverse Outcome Pathway in Pesticide Neurotoxicity. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 30796443 DOI: 10.1093/toxsci/kfz049  0.96
2019 Manne S, Kondru N, Hepker M, Jin H, Anantharam V, Lewis M, Huang X, Kanthasamy A, Kanthasamy AG. Ultrasensitive Detection of Aggregated α-Synuclein in Glial Cells, Human Cerebrospinal Fluid, and Brain Tissue Using the RT-QuIC Assay: New High-Throughput Neuroimmune Biomarker Assay for Parkinsonian Disorders. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. PMID 30706414 DOI: 10.1007/s11481-019-09835-4  0.96
2019 Sarkar S, Rokad D, Malovic E, Luo J, Harischandra DS, Jin H, Anantharam V, Huang X, Lewis M, Kanthasamy A, Kanthasamy AG. Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells. Science Signaling. 12. PMID 30622196 DOI: 10.1126/scisignal.aat9900  0.96
2018 Gordon R, Albornoz EA, Christie DC, Langley MR, Kumar V, Mantovani S, Robertson AAB, Butler MS, Rowe DB, O'Neill LA, Kanthasamy AG, Schroder K, Cooper MA, Woodruff TM. Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice. Science Translational Medicine. 10. PMID 30381407 DOI: 10.1126/scitranslmed.aah4066  0.44
2018 Brenza TM, Schlichtmann BW, Bhargavan B, Vela Ramirez JE, Nelson RD, Panthani MG, McMillan JM, Kalyanaraman B, Gendelman HE, Anantharam V, Kanthasamy AG, Mallapragada SK, Narasimhan B, Kanmogne GD. Biodegradable polyanhydride-based nanomedicines for blood to brain drug delivery. Journal of Biomedical Materials Research. Part A. PMID 30369055 DOI: 10.1002/jbm.a.36477  0.96
2018 Singh N, Lawana V, Luo J, Phong P, Abdalla A, Palanisamy B, Rokad D, Sarkar S, Jin H, Anantharam V, Kanthasamy AG, Kanthasamy A. Organophosphate pesticide chlorpyrifos impairs STAT1 signaling to induce dopaminergic neurotoxicity: Implications for mitochondria mediated oxidative stress signaling events. Neurobiology of Disease. PMID 29859868 DOI: 10.1016/j.nbd.2018.05.019  0.96
2018 Sarkar S, Malovic E, Sarda D, Lawana V, Rokad D, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Characterization and comparative analysis of a new mouse microglial cell model for studying neuroinflammatory mechanisms during neurotoxic insults. Neurotoxicology. PMID 29775624 DOI: 10.1016/j.neuro.2018.05.002  0.96
2017 Crowe TP, Greenlee MHW, Kanthasamy AG, Hsu WH. Mechanism of intranasal drug delivery directly to the brain. Life Sciences. PMID 29277310 DOI: 10.1016/j.lfs.2017.12.025  0.48
2017 Anantharam P, Whitley EM, Mahama B, Kim DS, Sarkar S, Santana C, Chan A, Kanthasamy AG, Kanthasamy A, Boss GR, Rumbeiha WK. Cobinamide is effective for treatment of hydrogen sulfide-induced neurological sequelae in a mouse model. Annals of the New York Academy of Sciences. 1408: 61-78. PMID 29239480 DOI: 10.1111/nyas.13559  0.4
2017 Sharma S, Carlson S, Puttachary S, Sarkar S, Showman L, Putra M, Kanthasamy AG, Thippeswamy T. Role of the Fyn-PKCδ signaling in SE-induced neuroinflammation and epileptogenesis in experimental models of temporal lobe epilepsy. Neurobiology of Disease. 110: 102-121. PMID 29197620 DOI: 10.1016/j.nbd.2017.11.008  0.4
2017 Manne S, Kondru N, Nichols T, Lehmkuhl A, Thomsen B, Main R, Halbur P, Dutta S, Kanthasamy AG. Ante-mortem detection of chronic wasting disease in recto-anal mucosa-associated lymphoid tissues from elk (Cervus elaphus nelsoni) using real-time quaking-induced conversion (RT-QuIC) assay: A blinded collaborative study. Prion. 1-16. PMID 29098931 DOI: 10.1080/19336896.2017.1368936  0.6
2017 Sarkar S, Malovic E, Harishchandra DS, Ghaisas S, Panicker N, Charli A, Palanisamy BN, Rokad D, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease. Npj Parkinson's Disease. 3: 30. PMID 29057315 DOI: 10.1038/s41531-017-0032-2  0.96
2017 Ngwa HA, Ay M, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Neurotoxicity of Vanadium. Advances in Neurobiology. 18: 287-301. PMID 28889273 DOI: 10.1007/978-3-319-60189-2_14  0.96
2017 Xu Q, Langley M, Kanthasamy AG, Reddy MB. Epigallocatechin Gallate Has a Neurorescue Effect in a Mouse Model of Parkinson Disease. The Journal of Nutrition. PMID 28835392 DOI: 10.3945/jn.117.255034  0.6
2017 Mammadova N, Ghaisas S, Zenitsky G, Sakaguchi DS, Kanthasamy AG, Greenlee JJ, West Greenlee MH. Lasting Retinal Injury in a Mouse Model of Blast-Induced Trauma. The American Journal of Pathology. PMID 28606756 DOI: 10.1016/j.ajpath.2017.03.005  0.76
2017 Sarkar S, Malovic E, Harischandra DS, Ngwa HA, Ghosh A, Hogan C, Rokad D, Zenitsky G, Jin H, Anantharam V, Kanthasamy AG, Kanthasamy A. Manganese exposure induces neuroinflammation by impairing mitochondrial dynamics in astrocytes. Neurotoxicology. PMID 28539244 DOI: 10.1016/j.neuro.2017.05.009  0.96
2017 Harischandra DS, Ghaisas S, Rokad D, Kanthasamy AG. Exosomes in Toxicology: Relevance to Chemical Exposure and Pathogenesis of Environmentally Linked Diseases. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 28505322 DOI: 10.1093/toxsci/kfx074  0.76
2017 Lawana V, Singh N, Sarkar S, Charli A, Jin H, Anantharam V, Kanthasamy AG, Kanthasamy A. Involvement of c-Abl Kinase in Microglial Activation of NLRP3 Inflammasome and Impairment in Autolysosomal System. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. PMID 28466394 DOI: 10.1007/s11481-017-9746-5  0.96
2017 Harischandra DS, Ghaisas S, Rokad D, Zamanian M, Jin H, Anantharam V, Kimber M, Kanthasamy A, Kanthasamy A. Environmental Neurotoxicant Manganese Regulates Exosome-mediated Extracellular miRNAs in Cell Culture Model of Parkinson's Disease: Relevance to α-Synuclein Misfolding in Metal Neurotoxicity. Neurotoxicology. PMID 28450057 DOI: 10.1016/j.neuro.2017.04.007  0.96
2017 Sarkar S, Malovic E, Plante B, Zenitsky G, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility. Journal of Visualized Experiments : Jove. PMID 28447995 DOI: 10.3791/55364  0.96
2017 Ay M, Luo J, Langley M, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Molecular Mechanisms Underlying Protective Effects of Quercetin Against Mitochondrial Dysfunction and Progressive Dopaminergic Neurodegeneration in Cell Culture and MitoPark Transgenic Mouse Models of Parkinson's Disease. Journal of Neurochemistry. PMID 28376279 DOI: 10.1111/jnc.14033  0.96
2017 Langley M, Ghosh A, Charli A, Sarkar S, Ay M, Luo J, Zielonka J, Brenza T, Bennett B, Jin H, Ghaisas S, Schlichtmann B, Kim D, Anantharam V, Kanthasamy A, ... ... Kanthasamy AG, et al. Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice. Antioxidants & Redox Signaling. PMID 28375739 DOI: 10.1089/ars.2016.6905  0.96
2016 Rokad D, Ghaisas S, Harischandra DS, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Role of Neurotoxicants and Traumatic Brain Injury in α-Synuclein Protein Misfolding and Aggregation. Brain Research Bulletin. PMID 27993598 DOI: 10.1016/j.brainresbull.2016.12.003  0.96
2016 Brenza TM, Ghaisas S, Ramirez JE, Harischandra D, Anantharam V, Kalyanaraman B, Kanthasamy AG, Narasimhan B. Neuronal Protection against Oxidative Insult by Polyanhydride Nanoparticle-based Mitochondria-targeted Antioxidant Therapy. Nanomedicine : Nanotechnology, Biology, and Medicine. PMID 27771430 DOI: 10.1016/j.nano.2016.10.004  0.96
2016 Gordon R, Neal ML, Luo J, Langley MR, Harischandra DS, Panicker N, Charli A, Jin H, Anantharam V, Woodruff TM, Zhou QY, Kanthasamy AG, Kanthasamy A. Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration. Nature Communications. 7: 12932. PMID 27703142 DOI: 10.1038/ncomms12932  0.76
2016 Zhou QY, Burton KJ, Neal ML, Qiao Y, Kanthasamy AG, Sun Y, Xu X, Ma Y, Li X. Differential arousal regulation by prokineticin 2 signaling in the nocturnal mouse and the diurnal monkey. Molecular Brain. 9: 78. PMID 27535380 DOI: 10.1186/s13041-016-0255-x  0.96
2016 Xu Q, Kanthasamy AG, Jin H, Reddy MB. Hepcidin Plays a Key Role in 6-OHDA Induced Iron Overload and Apoptotic Cell Death in a Cell Culture Model of Parkinson's Disease. Parkinson's Disease. 2016: 8684130. PMID 27298749 DOI: 10.1155/2016/8684130  0.68
2016 Gordon R, Singh N, Lawana V, Ghosh A, Harischandra DS, Jin H, Hogan C, Sarkar S, Rokad D, Panicker N, Anantharam V, Kanthasamy AG, Kanthasamy A. Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease. Neurobiology of Disease. PMID 27151770 DOI: 10.1016/j.nbd.2016.04.008  0.76
2016 Kim DS, Jin H, Anantharam V, Gordon R, Kanthasamy A, Kanthasamy AG. p73 gene in Dopaminergic Neurons is Highly Susceptible to Manganese Neurotoxicity. Neurotoxicology. PMID 27107493 DOI: 10.1016/j.neuro.2016.04.012  0.8
2016 Ghosh A, Langley MR, Harischandra DS, Neal ML, Jin H, Anantharam V, Joseph J, Brenza T, Narasimhan B, Kanthasamy A, Kalyanaraman B, Kanthasamy AG. Mitoapocynin Treatment Protects Against Neuroinflammation and Dopaminergic Neurodegeneration in a Preclinical Animal Model of Parkinson's Disease. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. PMID 26838361 DOI: 10.1007/s11481-016-9650-4  0.8
2015 Chen D, Kanthasamy AG, Reddy MB. EGCG Protects against 6-OHDA-Induced Neurotoxicity in a Cell Culture Model. Parkinson's Disease. 2015: 843906. PMID 26770869 DOI: 10.1155/2015/843906  0.6
2015 Ross KA, Brenza TM, Binnebose AM, Phanse Y, Kanthasamy AG, Gendelman HE, Salem AK, Bartholomay LC, Bellaire BH, Narasimhan B. Nano-enabled delivery of diverse payloads across complex biological barriers. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 26315817 DOI: 10.1016/j.jconrel.2015.08.039  0.96
2015 Ay M, Jin H, Harischandra DS, Asaithambi A, Kanthasamy A, Anantharam V, Kanthasamy AG. Molecular cloning, epigenetic regulation, and functional characterization of Prkd1 gene promoter in dopaminergic cell culture models of Parkinson's disease. Journal of Neurochemistry. PMID 26230914 DOI: 10.1111/jnc.13261  0.8
2015 Panicker N, Saminathan H, Jin H, Neal M, Harischandra DS, Gordon R, Kanthasamy K, Lawana V, Sarkar S, Luo J, Anantharam V, Kanthasamy AG, Kanthasamy A. Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 10058-77. PMID 26157004 DOI: 10.1523/JNEUROSCI.0302-15.2015  0.76
2015 Charli A, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Alterations in mitochondrial dynamics induced by tebufenpyrad and pyridaben in a dopaminergic neuronal cell culture model. Neurotoxicology. PMID 26141520 DOI: 10.1016/j.neuro.2015.06.007  0.8
2015 Gendelman HE, Anantharam V, Bronich T, Ghaisas S, Jin H, Kanthasamy AG, Liu X, McMillan J, Mosley RL, Narasimhan B, Mallapragada SK. Nanoneuromedicines for degenerative, inflammatory, and infectious nervous system diseases. Nanomedicine : Nanotechnology, Biology, and Medicine. 11: 751-67. PMID 25645958 DOI: 10.1016/j.nano.2014.12.014  0.96
2015 Harischandra DS, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. α-Synuclein protects against manganese neurotoxic insult during the early stages of exposure in a dopaminergic cell model of Parkinson's disease. Toxicological Sciences : An Official Journal of the Society of Toxicology. 143: 454-68. PMID 25416158 DOI: 10.1093/toxsci/kfu247  0.8
2014 Faburay B, Tark D, Kanthasamy AG, Richt JA. In vitro amplification of scrapie and chronic wasting disease PrP(res) using baculovirus-expressed recombinant PrP as substrate. Prion. 8: 393-403. PMID 25495764 DOI: 10.4161/19336896.2014.983753  0.56
2014 Jin H, Kanthasamy A, Harischandra DS, Kondru N, Ghosh A, Panicker N, Anantharam V, Rana A, Kanthasamy AG. Histone hyperacetylation up-regulates protein kinase Cδ in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of neurodegeneration in Parkinson disease. The Journal of Biological Chemistry. 289: 34743-67. PMID 25342743 DOI: 10.1074/jbc.M114.576702  0.8
2014 Dranka BP, Gifford A, McAllister D, Zielonka J, Joseph J, O'Hara CL, Stucky CL, Kanthasamy AG, Kalyanaraman B. A novel mitochondrially-targeted apocynin derivative prevents hyposmia and loss of motor function in the leucine-rich repeat kinase 2 (LRRK2(R1441G)) transgenic mouse model of Parkinson's disease. Neuroscience Letters. 583: 159-64. PMID 25263790 DOI: 10.1016/j.neulet.2014.09.042  0.96
2014 Asaithambi A, Ay M, Jin H, Gosh A, Anantharam V, Kanthasamy A, Kanthasamy AG. Protein kinase D1 (PKD1) phosphorylation promotes dopaminergic neuronal survival during 6-OHDA-induced oxidative stress. Plos One. 9: e96947. PMID 24806360 DOI: 10.1371/journal.pone.0096947  0.8
2014 Harischandra DS, Kondru N, Martin DP, Kanthasamy A, Jin H, Anantharam V, Kanthasamy AG. Role of proteolytic activation of protein kinase Cδ in the pathogenesis of prion disease. Prion. 8: 143-53. PMID 24576946 DOI: 10.4161/pri.28369  0.8
2014 Ngwa HA, Kanthasamy A, Jin H, Anantharam V, Kanthasamy AG. Vanadium exposure induces olfactory dysfunction in an animal model of metal neurotoxicity. Neurotoxicology. 43: 73-81. PMID 24362016 DOI: 10.1016/j.neuro.2013.12.004  0.8
2014 Jin H, Kanthasamy A, Ghosh A, Anantharam V, Kalyanaraman B, Kanthasamy AG. Mitochondria-targeted antioxidants for treatment of Parkinson's disease: preclinical and clinical outcomes. Biochimica Et Biophysica Acta. 1842: 1282-94. PMID 24060637 DOI: 10.1016/j.bbadis.2013.09.007  0.8
2013 Ghosh A, Saminathan H, Kanthasamy A, Anantharam V, Jin H, Sondarva G, Harischandra DS, Qian Z, Rana A, Kanthasamy AG. The peptidyl-prolyl isomerase Pin1 up-regulation and proapoptotic function in dopaminergic neurons: relevance to the pathogenesis of Parkinson disease. The Journal of Biological Chemistry. 288: 21955-71. PMID 23754278 DOI: 10.1074/jbc.M112.444224  0.8
2013 Dranka BP, Gifford A, Ghosh A, Zielonka J, Joseph J, Kanthasamy AG, Kalyanaraman B. Diapocynin prevents early Parkinson's disease symptoms in the leucine-rich repeat kinase 2 (LRRK2R¹⁴⁴¹G) transgenic mouse. Neuroscience Letters. 549: 57-62. PMID 23721786 DOI: 10.1016/j.neulet.2013.05.034  0.72
2012 Ghosh A, Kanthasamy A, Joseph J, Anantharam V, Srivastava P, Dranka BP, Kalyanaraman B, Kanthasamy AG. Anti-inflammatory and neuroprotective effects of an orally active apocynin derivative in pre-clinical models of Parkinson's disease. Journal of Neuroinflammation. 9: 241. PMID 23092448 DOI: 10.1186/1742-2094-9-241  0.76
2012 Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... ... Kanthasamy AG, ... ... Kanthasamy A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490 DOI: 10.4161/auto.19496  0.96
2012 Dranka BP, Zielonka J, Kanthasamy AG, Kalyanaraman B. Alterations in bioenergetic function induced by Parkinson's disease mimetic compounds: lack of correlation with superoxide generation. Journal of Neurochemistry. 122: 941-51. PMID 22708893 DOI: 10.1111/j.1471-4159.2012.07836.x  0.72
2012 Gordon R, Anantharam V, Kanthasamy AG, Kanthasamy A. Proteolytic activation of proapoptotic kinase protein kinase Cδ by tumor necrosis factor α death receptor signaling in dopaminergic neurons during neuroinflammation. Journal of Neuroinflammation. 9: 82. PMID 22540228 DOI: 10.1186/1742-2094-9-82  0.76
2012 Shin EJ, Duong CX, Nguyen XK, Li Z, Bing G, Bach JH, Park DH, Nakayama K, Ali SF, Kanthasamy AG, Cadet JL, Nabeshima T, Kim HC. Role of oxidative stress in methamphetamine-induced dopaminergic toxicity mediated by protein kinase Cδ. Behavioural Brain Research. 232: 98-113. PMID 22512859 DOI: 10.1016/j.bbr.2012.04.001  0.72
2012 Lin M, Chandramani-Shivalingappa P, Jin H, Ghosh A, Anantharam V, Ali S, Kanthasamy AG, Kanthasamy A. Methamphetamine-induced neurotoxicity linked to ubiquitin-proteasome system dysfunction and autophagy-related changes that can be modulated by protein kinase C delta in dopaminergic neuronal cells. Neuroscience. 210: 308-32. PMID 22445524 DOI: 10.1016/j.neuroscience.2012.03.004  0.76
2012 Wong DM, Ghosh A, Fales-Williams AJ, Haynes JS, Kanthasamy AG. Evidence of oxidative injury of the spinal cord in 2 horses with equine degenerative myeloencephalopathy. Veterinary Pathology. 49: 1049-53. PMID 22390882 DOI: 10.1177/0300985812439074  0.76
2011 Kanthasamy K, Gordon R, Jin H, Anantharam V, Ali S, Kanthasamy AG, Kanthasamy A. Neuroprotective effect of resveratrol against methamphetamine-induced dopaminergic apoptotic cell death in a cell culture model of neurotoxicity. Current Neuropharmacology. 9: 49-53. PMID 21886561 DOI: 10.2174/157015911795017353  0.76
2011 Martin DP, Anantharam V, Jin H, Witte T, Houk R, Kanthasamy A, Kanthasamy AG. Infectious prion protein alters manganese transport and neurotoxicity in a cell culture model of prion disease. Neurotoxicology. 32: 554-62. PMID 21871919 DOI: 10.1016/j.neuro.2011.07.008  0.8
2011 Afeseh Ngwa H, Kanthasamy A, Gu Y, Fang N, Anantharam V, Kanthasamy AG. Manganese nanoparticle activates mitochondrial dependent apoptotic signaling and autophagy in dopaminergic neuronal cells. Toxicology and Applied Pharmacology. 256: 227-40. PMID 21856324 DOI: 10.1016/j.taap.2011.07.018  0.8
2011 Sun F, Kanthasamy AG, Kanthasamy A. Measurement of proteasomal dysfunction in cell models of dopaminergic degeneration. Methods in Molecular Biology (Clifton, N.J.). 758: 293-305. PMID 21815074 DOI: 10.1007/978-1-61779-170-3_20  0.8
2011 Saminathan H, Asaithambi A, Anantharam V, Kanthasamy AG, Kanthasamy A. Environmental neurotoxic pesticide dieldrin activates a non receptor tyrosine kinase to promote PKCδ-mediated dopaminergic apoptosis in a dopaminergic neuronal cell model. Neurotoxicology. 32: 567-77. PMID 21801747 DOI: 10.1016/j.neuro.2011.06.009  0.76
2011 Song C, Kanthasamy A, Jin H, Anantharam V, Kanthasamy AG. Paraquat induces epigenetic changes by promoting histone acetylation in cell culture models of dopaminergic degeneration. Neurotoxicology. 32: 586-95. PMID 21777615 DOI: 10.1016/j.neuro.2011.05.018  0.72
2011 Asaithambi A, Kanthasamy A, Saminathan H, Anantharam V, Kanthasamy AG. Protein kinase D1 (PKD1) activation mediates a compensatory protective response during early stages of oxidative stress-induced neuronal degeneration. Molecular Neurodegeneration. 6: 43. PMID 21696630 DOI: 10.1186/1750-1326-6-43  0.76
2011 Shin EJ, Duong CX, Nguyen TX, Bing G, Bach JH, Park DH, Nakayama K, Ali SF, Kanthasamy AG, Cadet JL, Nabeshima T, Kim HC. PKCδ inhibition enhances tyrosine hydroxylase phosphorylation in mice after methamphetamine treatment. Neurochemistry International. 59: 39-50. PMID 21672585 DOI: 10.1016/j.neuint.2011.03.022  0.72
2011 Jin H, Kanthasamy A, Anantharam V, Rana A, Kanthasamy AG. Transcriptional regulation of pro-apoptotic protein kinase Cdelta: implications for oxidative stress-induced neuronal cell death. The Journal of Biological Chemistry. 286: 19840-59. PMID 21467032 DOI: 10.1074/jbc.M110.203687  0.8
2011 Xu Q, Kanthasamy AG, Reddy MB. Phytic Acid Protects against 6-Hydroxydopamine-Induced Dopaminergic Neuron Apoptosis in Normal and Iron Excess Conditions in a Cell Culture Model. Parkinson's Disease. 2011: 431068. PMID 21331377 DOI: 10.4061/2011/431068  0.6
2011 Jin H, Kanthasamy A, Ghosh A, Yang Y, Anantharam V, Kanthasamy AG. α-Synuclein negatively regulates protein kinase Cδ expression to suppress apoptosis in dopaminergic neurons by reducing p300 histone acetyltransferase activity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 2035-51. PMID 21307242 DOI: 10.1523/JNEUROSCI.5634-10.2011  0.8
2011 Gordon R, Hogan CE, Neal ML, Anantharam V, Kanthasamy AG, Kanthasamy A. A simple magnetic separation method for high-yield isolation of pure primary microglia. Journal of Neuroscience Methods. 194: 287-96. PMID 21074565 DOI: 10.1016/j.jneumeth.2010.11.001  0.76
2010 Choi CJ, Anantharam V, Martin DP, Nicholson EM, Richt JA, Kanthasamy A, Kanthasamy AG. Manganese upregulates cellular prion protein and contributes to altered stabilization and proteolysis: relevance to role of metals in pathogenesis of prion disease. Toxicological Sciences : An Official Journal of the Society of Toxicology. 115: 535-46. PMID 20176619 DOI: 10.1093/toxsci/kfq049  0.8
2010 Song C, Kanthasamy A, Anantharam V, Sun F, Kanthasamy AG. Environmental neurotoxic pesticide increases histone acetylation to promote apoptosis in dopaminergic neuronal cells: relevance to epigenetic mechanisms of neurodegeneration. Molecular Pharmacology. 77: 621-32. PMID 20097775 DOI: 10.1124/mol.109.062174  0.8
2009 Ortiz-Ortiz MA, Morán JM, Bravosanpedro JM, González-Polo RA, Niso-Santano M, Anantharam V, Kanthasamy AG, Soler G, Fuentes JM. Curcumin enhances paraquat-induced apoptosis of N27 mesencephalic cells via the generation of reactive oxygen species. Neurotoxicology. 30: 1008-18. PMID 19660496 DOI: 10.1016/j.neuro.2009.07.016  0.72
2009 Afeseh Ngwa H, Kanthasamy A, Anantharam V, Song C, Witte T, Houk R, Kanthasamy AG. Vanadium induces dopaminergic neurotoxicity via protein kinase Cdelta dependent oxidative signaling mechanisms: relevance to etiopathogenesis of Parkinson's disease. Toxicology and Applied Pharmacology. 240: 273-85. PMID 19646462 DOI: 10.1016/j.taap.2009.07.025  0.8
2009 Sun F, Kanthasamy A, Anantharam V, Kanthasamy AG. Mitochondrial accumulation of polyubiquitinated proteins and differential regulation of apoptosis by polyubiquitination sites Lys-48 and -63. Journal of Cellular and Molecular Medicine. 13: 1632-43. PMID 19432818 DOI: 10.1111/j.1582-4934.2009.00775.x  0.8
2008 Kanthasamy AG, Kitazawa M, Yang Y, Anantharam V, Kanthasamy A. Environmental neurotoxin dieldrin induces apoptosis via caspase-3-dependent proteolytic activation of protein kinase C delta (PKCdelta): Implications for neurodegeneration in Parkinson's disease. Molecular Brain. 1: 12. PMID 18945348 DOI: 10.1186/1756-6606-1-12  0.8
2008 Anantharam V, Kanthasamy A, Choi CJ, Martin DP, Latchoumycandane C, Richt JA, Kanthasamy AG. Opposing roles of prion protein in oxidative stress- and ER stress-induced apoptotic signaling. Free Radical Biology & Medicine. 45: 1530-41. PMID 18835352 DOI: 10.1016/j.freeradbiomed.2008.08.028  0.8
2008 Sun F, Kanthasamy A, Song C, Yang Y, Anantharam V, Kanthasamy AG. Proteasome inhibitor-induced apoptosis is mediated by positive feedback amplification of PKCdelta proteolytic activation and mitochondrial translocation. Journal of Cellular and Molecular Medicine. 12: 2467-81. PMID 18298651 DOI: 10.1111/j.1582-4934.2008.00293.x  0.8
2008 Xu Q, Kanthasamy AG, Reddy MB. Neuroprotective effect of the natural iron chelator, phytic acid in a cell culture model of Parkinson's disease. Toxicology. 245: 101-8. PMID 18255213 DOI: 10.1016/j.tox.2007.12.017  0.6
2007 Anantharam V, Kaul S, Song C, Kanthasamy A, Kanthasamy AG. Pharmacological inhibition of neuronal NADPH oxidase protects against 1-methyl-4-phenylpyridinium (MPP+)-induced oxidative stress and apoptosis in mesencephalic dopaminergic neuronal cells. Neurotoxicology. 28: 988-97. PMID 17904225 DOI: 10.1016/j.neuro.2007.08.008  0.8
2007 Zhang D, Anantharam V, Kanthasamy A, Kanthasamy AG. Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease. The Journal of Pharmacology and Experimental Therapeutics. 322: 913-22. PMID 17565007 DOI: 10.1124/jpet.107.124669  0.8
2007 Sun F, Kanthasamy A, Anantharam V, Kanthasamy AG. Environmental neurotoxic chemicals-induced ubiquitin proteasome system dysfunction in the pathogenesis and progression of Parkinson's disease. Pharmacology & Therapeutics. 114: 327-44. PMID 17521740 DOI: 10.1016/j.pharmthera.2007.04.001  0.8
2007 Choi CJ, Anantharam V, Saetveit NJ, Houk RS, Kanthasamy A, Kanthasamy AG. Normal cellular prion protein protects against manganese-induced oxidative stress and apoptotic cell death. Toxicological Sciences : An Official Journal of the Society of Toxicology. 98: 495-509. PMID 17483122 DOI: 10.1093/toxsci/kfm099  0.8
2007 Anantharam V, Lehrmann E, Kanthasamy A, Yang Y, Banerjee P, Becker KG, Freed WJ, Kanthasamy AG. Microarray analysis of oxidative stress regulated genes in mesencephalic dopaminergic neuronal cells: relevance to oxidative damage in Parkinson's disease. Neurochemistry International. 50: 834-47. PMID 17397968 DOI: 10.1016/j.neuint.2007.02.003  0.8
2006 Kanthasamy AG, Anantharam V, Zhang D, Latchoumycandane C, Jin H, Kaul S, Kanthasamy A. A novel peptide inhibitor targeted to caspase-3 cleavage site of a proapoptotic kinase protein kinase C delta (PKCdelta) protects against dopaminergic neuronal degeneration in Parkinson's disease models. Free Radical Biology & Medicine. 41: 1578-89. PMID 17045926 DOI: 10.1016/j.freeradbiomed.2006.08.016  0.8
2006 Sun F, Anantharam V, Zhang D, Latchoumycandane C, Kanthasamy A, Kanthasamy AG. Proteasome inhibitor MG-132 induces dopaminergic degeneration in cell culture and animal models. Neurotoxicology. 27: 807-15. PMID 16870259 DOI: 10.1016/j.neuro.2006.06.006  0.8
2006 Choi CJ, Kanthasamy A, Anantharam V, Kanthasamy AG. Interaction of metals with prion protein: possible role of divalent cations in the pathogenesis of prion diseases. Neurotoxicology. 27: 777-87. PMID 16860868 DOI: 10.1016/j.neuro.2006.06.004  0.8
2005 Kanthasamy AG, Kitazawa M, Kanthasamy A, Anantharam V. Dieldrin-induced neurotoxicity: relevance to Parkinson's disease pathogenesis. Neurotoxicology. 26: 701-19. PMID 16112328 DOI: 10.1016/j.neuro.2004.07.010  0.8
2005 Sun F, Anantharam V, Latchoumycandane C, Kanthasamy A, Kanthasamy AG. Dieldrin induces ubiquitin-proteasome dysfunction in alpha-synuclein overexpressing dopaminergic neuronal cells and enhances susceptibility to apoptotic cell death. The Journal of Pharmacology and Experimental Therapeutics. 315: 69-79. PMID 15987830 DOI: 10.1124/jpet.105.084632  0.96
2005 Kaul S, Anantharam V, Kanthasamy A, Kanthasamy AG. Wild-type alpha-synuclein interacts with pro-apoptotic proteins PKCdelta and BAD to protect dopaminergic neuronal cells against MPP+-induced apoptotic cell death. Brain Research. Molecular Brain Research. 139: 137-52. PMID 15978696 DOI: 10.1016/j.molbrainres.2005.05.022  0.8
2005 Kaul S, Anantharam V, Yang Y, Choi CJ, Kanthasamy A, Kanthasamy AG. Tyrosine phosphorylation regulates the proteolytic activation of protein kinase Cdelta in dopaminergic neuronal cells. The Journal of Biological Chemistry. 280: 28721-30. PMID 15961393 DOI: 10.1074/jbc.M501092200  0.8
2005 Engelman HM, Alekel DL, Hanson LN, Kanthasamy AG, Reddy MB. Blood lipid and oxidative stress responses to soy protein with isoflavones and phytic acid in postmenopausal women. The American Journal of Clinical Nutrition. 81: 590-6. PMID 15755827  0.6
2005 Latchoumycandane C, Anantharam V, Kitazawa M, Yang Y, Kanthasamy A, Kanthasamy AG. Protein kinase Cdelta is a key downstream mediator of manganese-induced apoptosis in dopaminergic neuronal cells. The Journal of Pharmacology and Experimental Therapeutics. 313: 46-55. PMID 15608081 DOI: 10.1124/jpet.104.078469  0.8
2005 Kitazawa M, Anantharam V, Yang Y, Hirata Y, Kanthasamy A, Kanthasamy AG. Activation of protein kinase C delta by proteolytic cleavage contributes to manganese-induced apoptosis in dopaminergic cells: protective role of Bcl-2. Biochemical Pharmacology. 69: 133-46. PMID 15588722 DOI: 10.1016/j.bcp.2004.08.035  0.8
2004 Anantharam V, Kitazawa M, Latchoumycandane C, Kanthasamy A, Kanthasamy AG. Blockade of PKCdelta proteolytic activation by loss of function mutants rescues mesencephalic dopaminergic neurons from methylcyclopentadienyl manganese tricarbonyl (MMT)-induced apoptotic cell death. Annals of the New York Academy of Sciences. 1035: 271-89. PMID 15681813 DOI: 10.1196/annals.1332.017  0.72
2004 Kitazawa M, Anantharam V, Kanthasamy A, Kanthasamy AG. Dieldrin promotes proteolytic cleavage of poly(ADP-ribose) polymerase and apoptosis in dopaminergic cells: protective effect of mitochondrial anti-apoptotic protein Bcl-2. Neurotoxicology. 25: 589-98. PMID 15183012 DOI: 10.1016/j.neuro.2003.09.014  0.8
2004 Yang Y, Kaul S, Zhang D, Anantharam V, Kanthasamy AG. Suppression of caspase-3-dependent proteolytic activation of protein kinase C delta by small interfering RNA prevents MPP+-induced dopaminergic degeneration. Molecular and Cellular Neurosciences. 25: 406-21. PMID 15033169 DOI: 10.1016/j.mcn.2003.11.011  0.96
2003 Kanthasamy AG, Kitazawa M, Kaul S, Yang Y, Lahiri DK, Anantharam V, Kanthasamy A. Proteolytic activation of proapoptotic kinase PKCdelta is regulated by overexpression of Bcl-2: implications for oxidative stress and environmental factors in Parkinson's disease. Annals of the New York Academy of Sciences. 1010: 683-6. PMID 15033812 DOI: 10.1196/annals.1299.125  0.72
2003 Kanthasamy AG, Kitazawa M, Kanthasamy A, Anantharam V. Role of proteolytic activation of protein kinase Cdelta in oxidative stress-induced apoptosis. Antioxidants & Redox Signaling. 5: 609-20. PMID 14580317 DOI: 10.1089/152308603770310275  0.8
2003 Kaul S, Kanthasamy A, Kitazawa M, Anantharam V, Kanthasamy AG. Caspase-3 dependent proteolytic activation of protein kinase C delta mediates and regulates 1-methyl-4-phenylpyridinium (MPP+)-induced apoptotic cell death in dopaminergic cells: relevance to oxidative stress in dopaminergic degeneration. The European Journal of Neuroscience. 18: 1387-401. PMID 14511319 DOI: 10.1046/j.1460-9568.2003.02864.x  0.8
2003 Kitazawa M, Anantharam V, Kanthasamy AG. Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cdelta in dopaminergic cells: relevance to oxidative stress and dopaminergic degeneration. Neuroscience. 119: 945-64. PMID 12831855 DOI: 10.1016/S0306-4522(03)00226-4  0.96
2003 Madhavan L, Freed WJ, Anantharam V, Kanthasamy AG. 5-hydroxytryptamine 1A receptor activation protects against N-methyl-D-aspartate-induced apoptotic cell death in striatal and mesencephalic cultures. The Journal of Pharmacology and Experimental Therapeutics. 304: 913-23. PMID 12604665 DOI: 10.1124/jpet.102.044370  0.96
2002 Kitazawa M, Wagner JR, Kirby ML, Anantharam V, Kanthasamy AG. Oxidative stress and mitochondrial-mediated apoptosis in dopaminergic cells exposed to methylcyclopentadienyl manganese tricarbonyl. The Journal of Pharmacology and Experimental Therapeutics. 302: 26-35. PMID 12065696 DOI: 10.1124/jpet.302.1.26  0.96
2002 Anantharam V, Kitazawa M, Wagner J, Kaul S, Kanthasamy AG. Caspase-3-dependent proteolytic cleavage of protein kinase Cdelta is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 1738-51. PMID 11880503  0.96
2001 Kitazawa M, Anantharam V, Kanthasamy AG. Dieldrin-induced oxidative stress and neurochemical changes contribute to apoptopic cell death in dopaminergic cells. Free Radical Biology & Medicine. 31: 1473-85. PMID 11728820 DOI: 10.1016/S0891-5849(01)00726-2  0.96
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