Rodrigo A. Cunha, PhD - Publications

Center for Neuroscience and Cell Biology University of Coimbra, Coimbra, Coimbra, Portugal 

255 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Lopes CR, Gonçalves FQ, Olaio S, Tomé AR, Cunha RA, Lopes JP. Adenosine A Receptors Shut Down Adenosine A Receptor-Mediated Presynaptic Inhibition to Promote Implementation of Hippocampal Long-Term Potentiation. Biomolecules. 13. PMID 37189461 DOI: 10.3390/biom13040715  0.328
2023 Gonçalves FQ, Valada P, Matos M, Cunha RA, Tomé AR. Feedback facilitation by adenosine A receptors of ATP release from mouse hippocampal nerve terminals. Purinergic Signalling. PMID 36997740 DOI: 10.1007/s11302-023-09937-y  0.316
2023 Lopes CR, Oliveira A, Gaspar I, Rodrigues MS, Santos J, Szabó E, Silva HB, Tomé ÂR, Canas PM, Agostinho P, Carvalho RA, Cunha RA, Simões AP, Lopes JP, Ferreira SG. Effects of Chronic Caffeine Consumption on Synaptic Function, Metabolism and Adenosine Modulation in Different Brain Areas. Biomolecules. 13. PMID 36671491 DOI: 10.3390/biom13010106  0.596
2022 Gonçalves FQ, Matheus FC, Silva HB, Real JI, Rial D, Rodrigues RJ, Oses JP, Silva AC, Gonçalves N, Prediger RD, Tomé ÂR, Cunha RA. Increased ATP Release and Higher Impact of Adenosine A Receptors on Corticostriatal Plasticity in a Rat Model of Presymptomatic Parkinson's Disease. Molecular Neurobiology. PMID 36547848 DOI: 10.1007/s12035-022-03162-1  0.302
2022 Valada P, Hinz S, Vielmuth C, Lopes CR, Cunha RA, Müller CE, Lopes JP. The impact of inosine on hippocampal synaptic transmission and plasticity involves the release of adenosine through equilibrative nucleoside transporters rather than the direct activation of adenosine receptors. Purinergic Signalling. PMID 36156760 DOI: 10.1007/s11302-022-09899-7  0.398
2022 Valada P, Alçada-Morais S, Cunha RA, Lopes JP. Thebromine Targets Adenosine Receptors to Control Hippocampal Neuronal Function and Damage. International Journal of Molecular Sciences. 23. PMID 36142422 DOI: 10.3390/ijms231810510  0.324
2022 Madeira D, Dias L, Santos P, Cunha RA, Agostinho P, Canas PM. Adenosine A receptors blockade attenuates dexamethasone-induced alterations in cultured astrocytes. Purinergic Signalling. PMID 35476241 DOI: 10.1007/s11302-022-09864-4  0.314
2022 Rodrigues MS, Ferreira SG, Quiroz C, Earley CJ, García-Borreguero D, Cunha RA, Ciruela F, Köfalvi A, Ferré S. Brain Iron Deficiency Changes the Stoichiometry of Adenosine Receptor Subtypes in Cortico-Striatal Terminals: Implications for Restless Legs Syndrome. Molecules (Basel, Switzerland). 27. PMID 35268590 DOI: 10.3390/molecules27051489  0.636
2021 Dias L, Lopes CR, Gonçalves FQ, Nunes A, Pochmann D, Machado NJ, Tomé AR, Agostinho P, Cunha RA. Crosstalk Between ATP-P and Adenosine A Receptors Controlling Neuroinflammation in Rats Subject to Repeated Restraint Stress. Frontiers in Cellular Neuroscience. 15: 639322. PMID 33732112 DOI: 10.3389/fncel.2021.639322  0.3
2020 Lopes CR, Lourenço VS, Tomé ÂR, Cunha RA, Canas PM. Use of knockout mice to explore CNS effects of adenosine. Biochemical Pharmacology. 114367. PMID 33333075 DOI: 10.1016/j.bcp.2020.114367  0.359
2020 Lopes CR, Lourenço VS, Tomé ÂR, Cunha RA, Canas PM. Use of knockout mice to explore CNS effects of adenosine. Biochemical Pharmacology. 114367. PMID 33333075 DOI: 10.1016/j.bcp.2020.114367  0.359
2020 Fonteles AA, Neves JCS, Menezes APF, Pereira JF, Silva ATA, Cunha RA, Andrade GM. ATP Signaling Controlling Dyskinesia Through P2X7 Receptors. Frontiers in Molecular Neuroscience. 13: 111. PMID 32848592 DOI: 10.3389/fnmol.2020.00111  0.394
2020 Rodrigues MS, Ferreira C, Dias C, Pliássova A, Souza L, Ledo A, Laranjinha J, Cunha RA, Köfalvi A. An optimized spectrophotometric assay reveals increased activity of enzymes involved in 2-arachidonoyl glycerol turnover in the cerebral cortex of a rat model of Alzheimer's disease. The European Journal of Neuroscience. PMID 32813905 DOI: 10.1111/Ejn.14944  0.321
2020 Aguiar AS, Speck AE, Canas PM, Cunha RA. Neuronal adenosine A receptors signal ergogenic effects of caffeine. Scientific Reports. 10: 13414. PMID 32770138 DOI: 10.1038/s41598-020-69660-1  0.333
2020 França AP, Schamne MG, de Souza BS, da Luz Scheffer D, Bernardelli AK, Corrêa T, de Souza Izídio G, Latini A, da Silva-Santos JE, Canas PM, Cunha RA, Prediger RD. Caffeine Consumption plus Physical Exercise Improves Behavioral Impairments and Stimulates Neuroplasticity in Spontaneously Hypertensive Rats (SHR): an Animal Model of Attention Deficit Hyperactivity Disorder. Molecular Neurobiology. PMID 32621279 DOI: 10.1007/s12035-020-02002-4  0.314
2020 Pedro JR, Moura LIF, Valério-Fernandes Â, Baptista FI, Gaspar JM, Pinheiro BS, Lemos C, Kaufmann FN, Morgado C, Silva-Santos CSD, Tavares I, Ferreira SG, Carvalho E, Ambrósio AF, Cunha RA, et al. Transient Gain of Function of Cannabinoid CB Receptors in the Control of Frontocortical Glucose Consumption in a Rat Model of Type-1 Diabetes. Brain Research Bulletin. PMID 32428627 DOI: 10.1016/j.brainresbull.2020.05.004  0.372
2020 Chen JF, Cunha RA. The belated US FDA approval of the adenosine A receptor antagonist istradefylline for treatment of Parkinson's disease. Purinergic Signalling. PMID 32236790 DOI: 10.1007/s11302-020-09694-2  0.306
2020 Köfalvi A, Moreno E, Cordomí A, Cai NS, Fernández-Dueñas V, Ferreira SG, Guixà-González R, Sánchez-Soto M, Yano H, Casadó-Anguera V, Cunha RA, Sebastião AM, Ciruela F, Pardo L, Casadó V, et al. Control of glutamate release by complexes of adenosine and cannabinoid receptors. Bmc Biology. 18: 9. PMID 31973708 DOI: 10.1186/S12915-020-0739-0  0.665
2020 Gonçalves N, Machado N, Simões A, Cunha R. Selective Down-Regulation of Neuronal A2A Receptors in the Basolateral Amygdala Prevents Behavioural Modifications Induced by Repeated Stress Biological Psychiatry. 87: S220. DOI: 10.1016/j.biopsych.2020.02.571  0.361
2019 Cunha RA. Overactivity of neuronal adenosine A2A receptors accelerates neurodegeneration. Brain : a Journal of Neurology. 142: 3323-3324. PMID 31665752 DOI: 10.1093/brain/awz335  0.396
2019 Gonçalves FQ, Lopes JP, Silva HB, Lemos C, Silva AC, Gonçalves N, Tomé ÂR, Ferreira SG, Canas PM, Rial D, Agostinho P, Cunha RA. Synaptic and memory dysfunction in a β-amyloid model of early Alzheimer's disease depends on increased formation of ATP-derived extracellular adenosine. Neurobiology of Disease. 104570. PMID 31394204 DOI: 10.1016/j.nbd.2019.104570  0.384
2019 Morato X, Cunha RA, Ciruela F. G protein-coupled receptor 37 (GPR37) emerges as an important modulator of adenosinergic transmission in the striatum. Neural Regeneration Research. 14: 1912-1914. PMID 31290447 DOI: 10.4103/1673-5374.259610  0.344
2019 Reis SL, Silva HB, Almeida M, Cunha RA, Simões AP, Canas PM. Adenosine A and A receptors differently control synaptic plasticity in the mouse dorsal and ventral hippocampus. Journal of Neurochemistry. PMID 31274188 DOI: 10.1111/jnc.14816  0.423
2019 Carmo M, Gonçalves FQ, Canas PM, Oses JP, Fernandes FD, Duarte FV, Palmeira CM, Tomé AR, Agostinho P, Andrade GM, Cunha RA. ENHANCED ATP RELEASE AND CD73-MEDIATED ADENOSINE FORMATION SUSTAIN ADENOSINE A RECEPTOR OVER-ACTIVATION IN A RAT MODEL OF PARKINSON'S DISEASE. British Journal of Pharmacology. PMID 31220343 DOI: 10.1111/bph.14771  0.363
2019 Lopes JP, Pliássova A, Cunha RA. The physiological effects of caffeine on synaptic transmission and plasticity in the mouse hippocampus selectively depend on adenosine A and A receptors. Biochemical Pharmacology. 166: 313-321. PMID 31199895 DOI: 10.1016/j.bcp.2019.06.008  0.426
2019 Lopes JP, Cunha RA. What is the extracellular calcium concentration within brain synapses?: An Editorial for 'Ionized calcium in human cerebrospinal fluid and its influence on intrinsic and synaptic excitability of hippocampal pyramidal neurons in the rat' on doi:10.1111/jnc.14693. Journal of Neurochemistry. PMID 31062363 DOI: 10.1111/jnc.14696  0.341
2019 Cunha RA. Signaling by adenosine receptors--Homeostatic or allostatic control? Plos Biology. 17: e3000213. PMID 30951527 DOI: 10.1371/journal.pbio.3000213  0.375
2019 Leffa DT, Ferreira SG, Machado NJ, Souza CM, da Rosa F, de Carvalho C, Kincheski GC, Takahashi RN, Porciúncula LO, Souza DO, Cunha RA, Pandolfo P. Caffeine and cannabinoid receptors modulate impulsive behavior in an animal model of Attentional Deficit and Hyperactivity Disorder. The European Journal of Neuroscience. PMID 30667546 DOI: 10.1111/Ejn.14348  0.367
2018 Duarte JMN, Skoug C, Silva HB, Carvalho RA, Gruetter R, Cunha RA. Impact of Caffeine Consumption on Type 2 Diabetes-Induced Spatial Memory Impairment and Neurochemical Alterations in the Hippocampus. Frontiers in Neuroscience. 12: 1015. PMID 30686981 DOI: 10.3389/Fnins.2018.01015  0.675
2018 Canas PM, Porciúncula LO, Simões AP, Augusto E, Silva HB, Machado NJ, Gonçalves N, Alfaro TM, Gonçalves FQ, Araújo IM, Real JI, Coelho JE, Andrade GM, Almeida RD, Chen JF, ... ... Cunha RA, et al. Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions. Eneuro. 5. PMID 30627646 DOI: 10.1523/ENEURO.0385-18.2018  0.332
2018 Leffa DT, Pandolfo P, Gonçalves N, Machado NJ, de Souza CM, Real JI, Silva AC, Silva HB, Köfalvi A, Cunha RA, Ferreira SG. Adenosine A Receptors in the Rat Prelimbic Medial Prefrontal Cortex Control Delay-Based Cost-Benefit Decision Making. Frontiers in Molecular Neuroscience. 11: 475. PMID 30618621 DOI: 10.3389/fnmol.2018.00475  0.341
2018 Morató X, Gonçalves FQ, Lopes JP, Jauregui O, Soler C, Fernández-Dueñas V, Cunha RA, Ciruela F. Chronic adenosine A receptor blockade induces locomotor sensitization and potentiates striatal LTD in GPR37 deficient mice. Journal of Neurochemistry. PMID 30578680 DOI: 10.1111/Jnc.14653  0.397
2018 Rodrigues RJ, Marques JM, Cunha RA. Purinergic signalling and brain development. Seminars in Cell & Developmental Biology. PMID 30529149 DOI: 10.1016/j.semcdb.2018.12.001  0.386
2018 Duarte JM, Gaspar R, Caetano L, Patrício P, Soares-Cunha C, Mateus-Pinheiro A, Alves ND, Santos AR, Ferreira SG, Sardinha V, Oliveira JF, Fontes-Ribeiro C, Sousa N, Cunha RA, Ambrósio AF, et al. Region-specific control of microglia by adenosine A receptors: uncoupling anxiety and associated cognitive deficits in female rats. Glia. PMID 30461068 DOI: 10.1002/Glia.23476  0.332
2018 Moreira-Silva D, Carrettiero DC, Oliveira ASA, Rodrigues S, Dos Santos-Lopes J, Canas PM, Cunha RA, Almeida MC, Ferreira TL. Anandamide Effects in a Streptozotocin-Induced Alzheimer's Disease-Like Sporadic Dementia in Rats. Frontiers in Neuroscience. 12: 653. PMID 30333717 DOI: 10.3389/fnins.2018.00653  0.376
2018 Dobrachinski F, Gerbatin RR, Sartori G, Golombieski RM, Antoniazzi A, Nogueira CW, Royes LF, Fighera MR, Porciúncula LO, Cunha RA, Soares FAA. Guanosine Attenuates Behavioral Deficits After Traumatic Brain Injury by Modulation of Adenosinergic Receptors. Molecular Neurobiology. PMID 30105669 DOI: 10.1007/s12035-018-1296-1  0.399
2018 Morató X, Luján R, Gonçalves N, Watanabe M, Altafaj X, Carvalho AL, Fernández-Dueñas V, Cunha RA, Ciruela F. Metabotropic glutamate type 5 receptor requires contactin-associated protein 1 to control memory formation. Human Molecular Genetics. PMID 30010864 DOI: 10.1093/Hmg/Ddy264  0.411
2018 Temido-Ferreira M, Ferreira DG, Batalha VL, Marques-Morgado I, Coelho JE, Pereira P, Gomes R, Pinto A, Carvalho S, Canas PM, Cuvelier L, Buée-Scherrer V, Faivre E, Baqi Y, Müller CE, ... ... Cunha RA, et al. Age-related shift in LTD is dependent on neuronal adenosine A receptors interplay with mGluR5 and NMDA receptors. Molecular Psychiatry. PMID 29950682 DOI: 10.1038/S41380-018-0110-9  0.441
2018 Silva AC, Lemos C, Gonçalves FQ, Pliássova AV, Machado NJ, Silva HB, Canas PM, Cunha RA, Lopes JP, Agostinho P. Blockade of adenosine A receptors recovers early deficits of memory and plasticity in the triple transgenic mouse model of Alzheimer's disease. Neurobiology of Disease. PMID 29859867 DOI: 10.1016/j.nbd.2018.05.024  0.405
2018 Kerkhofs A, Canas PM, Timmerman AJ, Heistek TS, Real JI, Xavier C, Cunha RA, Mansvelder HD, Ferreira SG. Adenosine AReceptors Control Glutamatergic Synaptic Plasticity in Fast Spiking Interneurons of the Prefrontal Cortex. Frontiers in Pharmacology. 9: 133. PMID 29615897 DOI: 10.3389/fphar.2018.00133  0.367
2018 Real JI, Simões AP, Cunha RA, Ferreira SG, Rial D. Adenosine Areceptors modulate the dopamine Dreceptor-mediated inhibition of synaptic transmission in the mouse prefrontal cortex. The European Journal of Neuroscience. PMID 29570875 DOI: 10.1111/ejn.13912  0.42
2018 Simões AP, Silva CG, Marques JM, Pochmann D, Porciúncula LO, Ferreira S, Oses JP, Beleza RO, Real JI, Köfalvi A, Bahr BA, Lerma J, Cunha RA, Rodrigues RJ. Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation. Cell Death & Disease. 9: 297. PMID 29463792 DOI: 10.1038/s41419-018-0351-1  0.412
2018 Rodrigues-Neves AC, Aires ID, Vindeirinho J, Boia R, Madeira MH, Gonçalves FQ, Cunha RA, Santos PF, Ambrósio AF, Santiago AR. Elevated Pressure Changes the Purinergic System of Microglial Cells. Frontiers in Pharmacology. 9: 16. PMID 29416510 DOI: 10.3389/fphar.2018.00016  0.383
2018 Duarte J, Gaspar R, Caetano L, Patrício P, Cunha C, Mateus-Pinheiro A, Alves N, Santos A, Ferreira S, Sardinha V, Oliveira J, Sousa N, Cunha R, Ambrósio F, Rodrigues A, et al. Brain region-specific control of microglia by adenosine A2A-adenosine receptors: uncoupling anxiety and cognition in female rodents European Neuropsychopharmacology. 28. DOI: 10.1016/J.Euroneuro.2017.12.058  0.308
2017 Henriques V, Gonçalves N, Agostinho P, Cunha RA. Astrocytic A2A receptors: Novel targets to manage brain disorders: . Porto Biomedical Journal. 2: 178-179. PMID 32258622 DOI: 10.1016/j.pbj.2017.07.011  0.325
2017 Kerkhofs A, Xavier AC, da Silva BS, Canas PM, Idema S, Baayen JC, Ferreira SG, Cunha RA, Mansvelder HD. Caffeine Controls Glutamatergic Synaptic Transmission and Pyramidal Neuron Excitability in Human Neocortex. Frontiers in Pharmacology. 8: 899. PMID 29354052 DOI: 10.3389/fphar.2017.00899  0.392
2017 Boia R, Elvas F, Madeira MH, Aires ID, Rodrigues-Neves AC, Tralhão P, Szabó EC, Baqi Y, Müller CE, Tomé ÂR, Cunha RA, Ambrósio AF, Santiago AR. Treatment with A2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage. Cell Death & Disease. 8: e3065. PMID 28981089 DOI: 10.1038/Cddis.2017.451  0.352
2017 Amorim JA, Canas PM, Tomé AR, Rolo AP, Agostinho P, Palmeira CM, Cunha RA. Mitochondria in Excitatory and Inhibitory Synapses have Similar Susceptibility to Amyloid-β Peptides Modeling Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 28869472 DOI: 10.3233/JAD-170356  0.342
2017 Morató X, Luján R, López-Cano M, Gandía J, Stagljar I, Watanabe M, Cunha RA, Fernández-Dueñas V, Ciruela F. The Parkinson's disease-associated GPR37 receptor interacts with striatal adenosine A2A receptor controlling its cell surface expression and function in vivo. Scientific Reports. 7: 9452. PMID 28842709 DOI: 10.1038/S41598-017-10147-X  0.445
2017 Morató X, López-Cano M, Canas PM, Cunha RA, Ciruela F. Brain Membrane Fractionation: An Ex Vivo Approach to Assess Subsynaptic Protein Localization. Journal of Visualized Experiments : Jove. PMID 28570537 DOI: 10.3791/55661  0.317
2017 Alfaro TM, Rodrigues DI, Tomé ÂR, Cunha RA, Cordeiro CR. Adenosine A2A receptors are up-regulated and control the activation of human alveolar macrophages. Pulmonary Pharmacology & Therapeutics. PMID 28499635 DOI: 10.1016/j.pupt.2017.04.009  0.3
2017 Santos VV, Stark R, Rial D, Silva HB, Bayliss JA, Lemus MB, Davies JS, Cunha RA, Prediger RD, Andrews ZB. Acyl ghrelin improves cognition, synaptic plasticity deficits and neuroinflammation following amyloid beta (Aβ1-40) administration in mice. Journal of Neuroendocrinology. PMID 28380673 DOI: 10.1111/Jne.12476  0.308
2016 Gonçalves N, Simões AT, Prediger RS, Hirai H, Cunha RA, Pereira de Almeida L. Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia. Annals of Neurology. PMID 28032667 DOI: 10.1002/Ana.24867  0.341
2016 Rial D, Morató X, Real JI, Gonçalves FQ, Stagljar I, Pereira FC, Fernández-Dueñas V, Cunha RA, Ciruela F. Parkinson's disease-associated GPR37 receptor regulates cocaine-mediated synaptic depression in corticostriatal synapses. Neuroscience Letters. PMID 28007645 DOI: 10.1016/J.Neulet.2016.12.040  0.334
2016 Duarte FV, Amorim JA, Varela AT, Teodoro JS, Gomes AP, Cunha RA, Palmeira CM, Rolo AP. Adenosine receptors: regulatory players in the preservation of mitochondrial function induced by ischemic preconditioning of rat liver. Purinergic Signalling. PMID 27848069 DOI: 10.1007/s11302-016-9548-x  0.331
2016 Fonseca R, Carvalho RA, Lemos C, Sequeira AC, Pita IR, Carvalho F, Silva CD, Prediger RD, Jarak I, Cunha RA, Fontes Ribeiro CA, Köfalvi A, Pereira FC. Methamphetamine Induces Anhedonic-Like Behavior and Impairs Frontal Cortical Energetics in Mice. Cns Neuroscience & Therapeutics. PMID 27762079 DOI: 10.1111/Cns.12649  0.533
2016 Caetano L, Pinheiro H, Patrício P, Mateus-Pinheiro A, Alves ND, Coimbra B, Baptista FI, Henriques SN, Cunha C, Santos AR, Ferreira SG, Sardinha VM, Oliveira JF, Ambrósio AF, Sousa N, ... Cunha RA, et al. Adenosine A2A receptor regulation of microglia morphological remodeling-gender bias in physiology and in a model of chronic anxiety. Molecular Psychiatry. PMID 27725661 DOI: 10.1038/Mp.2016.173  0.329
2016 Rodrigues L, Miranda IM, Andrade GM, Mota M, Cortes L, Rodrigues AG, Cunha RA, Gonçalves T. Blunted dynamics of adenosine A2A receptors is associated with increased susceptibility to Candida albicans infection in the elderly. Oncotarget. PMID 27590517 DOI: 10.18632/oncotarget.11760  0.328
2016 Cunha RA. How does adenosine control neuronal dysfunction and neurodegeneration? Journal of Neurochemistry. PMID 27365148 DOI: 10.1111/jnc.13724  0.409
2016 Viana da Silva S, Haberl MG, Zhang P, Bethge P, Lemos C, Gonçalves N, Gorlewicz A, Malezieux M, Gonçalves FQ, Grosjean N, Blanchet C, Frick A, Nägerl UV, Cunha RA, Mulle C. Early synaptic deficits in the APP/PS1 mouse model of Alzheimer's disease involve neuronal adenosine A2A receptors. Nature Communications. 7: 11915. PMID 27312972 DOI: 10.1038/Ncomms11915  0.401
2016 Simões AP, Machado NJ, Gonçalves N, Kaster MP, Simões AT, Nunes A, de Almeida LP, Goosens KA, Rial D, Cunha RA. Adenosine A2A Receptors in the Amygdala Control Synaptic Plasticity and Contextual Fear Memory. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27312408 DOI: 10.1038/Npp.2016.98  0.385
2016 George J, Cunha RA, Mulle C, Amédée T. Microglia-derived purines modulate mossy fibre synaptic transmission and plasticity through P2X4 and A1 receptors. The European Journal of Neuroscience. 43: 1366-78. PMID 27199162 DOI: 10.1111/Ejn.13191  0.461
2016 Pliássova A, Canas PM, Xavier AC, da Silva BS, Cunha RA, Agostinho P. Age-Related Changes in the Synaptic Density of Amyloid-β Protein Precursor and Secretases in the Human Cerebral Cortex. Journal of Alzheimer's Disease : Jad. PMID 27104908 DOI: 10.3233/JAD-160213  0.319
2016 Köfalvi A, Lemos C, Martín-Moreno AM, Pinheiro BS, García-García L, Pozo MA, Valério-Fernandes Â, Beleza RO, Agostinho P, Rodrigues RJ, Pasquaré SJ, Cunha RA, de Ceballos ML. Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer's disease. Neuropharmacology. PMID 26976670 DOI: 10.1016/j.neuropharm.2016.03.015  0.373
2016 Machado NJ, Simões AP, Silva HB, Ardais AP, Kaster MP, Garção P, Rodrigues DI, Pochmann D, Santos AI, Araújo IM, Porciúncula LO, Tomé ÂR, Köfalvi A, Vaugeois JM, Agostinho P, ... ... Cunha RA, et al. Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses. Molecular Neurobiology. PMID 26860412 DOI: 10.1007/S12035-016-9774-9  0.378
2016 Rodrigues RJ, Almeida T, Díaz-Hernández M, Marques JM, Franco R, Solsona C, Miras-Portugal MT, Ciruela F, Cunha RA. Presynaptic P2X1-3 and α3-containing Nicotinic Receptors Assemble Into Functionally Interacting Ion Channels in the Rat Hippocampus. Neuropharmacology. PMID 26801076 DOI: 10.1016/J.Neuropharm.2016.01.022  0.425
2016 Ardais AP, Rocha AS, Borges MF, Fioreze GT, Sallaberry C, Mioranzza S, Nunes F, Pagnussat N, Botton PH, Cunha RA, Porciúncula LO. Caffeine exposure during rat brain development causes memory impairment in a sex selective manner that is offset by caffeine consumption throughout life. Behavioural Brain Research. PMID 26774980 DOI: 10.1016/j.bbr.2016.01.026  0.346
2016 Lemos C, Rial D, Gonçalves FQ, Pires J, Silva HB, Matheus FC, da Silva AC, Marques JM, Rodrigues RJ, Jarak I, Prediger RD, Reis F, Carvalho RA, Pereira FC, Cunha RA. High sucrose consumption induces memory impairment in rats associated with electrophysiological modifications but not with metabolic changes in the hippocampus. Neuroscience. 315: 196-205. PMID 26704636 DOI: 10.1016/J.Neuroscience.2015.12.018  0.604
2015 Rial D, Lemos C, Pinheiro H, Duarte JM, Gonçalves FQ, Real JI, Prediger RD, Gonçalves N, Gomes CA, Canas PM, Agostinho P, Cunha RA. Depression as a Glial-Based Synaptic Dysfunction. Frontiers in Cellular Neuroscience. 9: 521. PMID 26834566 DOI: 10.3389/fncel.2015.00521  0.336
2015 Duarte JM, Cunha RA, Carvalho RA. Adenosine A1 receptors control the metabolic recovery after hypoxia in rat hippocampal slices. Journal of Neurochemistry. PMID 26709861 DOI: 10.1111/Jnc.13512  0.744
2015 Matheus FC, Rial D, Real JI, Lemos C, Ben J, Guaita GO, Pita IR, Sequeira AC, Pereira FC, Walz R, Takahashi RN, Bertoglio LJ, Cunha CD, Cunha RA, Prediger RD. Decreased synaptic plasticity in the medial prefrontal cortex underlies short-term memory deficits in 6-OHDA-lesioned rats. Behavioural Brain Research. PMID 26707254 DOI: 10.1016/J.Bbr.2015.12.011  0.323
2015 Madeira MH, Boia R, Elvas F, Martins T, Cunha RA, Ambrósio AF, Santiago AR. Selective A2A receptor antagonist prevents microglia-mediated neuroinflammation and protects retinal ganglion cells from high intraocular pressure-induced transient ischemic injury. Translational Research : the Journal of Laboratory and Clinical Medicine. PMID 26685039 DOI: 10.1016/j.trsl.2015.11.005  0.378
2015 Ferreira DG, Batalha VL, Vicente Miranda H, Coelho JE, Gomes R, Gonçalves FQ, Real JI, Rino J, Albino-Teixeira A, Cunha RA, Outeiro TF, Lopes LV. Adenosine A2A Receptors Modulate α-Synuclein Aggregation and Toxicity. Cerebral Cortex (New York, N.Y. : 1991). PMID 26534909 DOI: 10.1093/Cercor/Bhv268  0.409
2015 Pliássova A, Lopes JP, Lemos C, Oliveira CR, Cunha RA, Agostinho P. The Association of Amyloid-β Protein Precursor With α- and β-Secretases in Mouse Cerebral Cortex Synapses Is Altered in Early Alzheimer's Disease. Molecular Neurobiology. PMID 26497029 DOI: 10.1007/s12035-015-9491-9  0.307
2015 Lemos C, Pinheiro BS, Beleza RO, Marques JM, Rodrigues RJ, Cunha RA, Rial D, Köfalvi A. Adenosine A2B receptor activation stimulates glucose uptake in the mouse forebrain. Purinergic Signalling. PMID 26446689 DOI: 10.1007/s11302-015-9474-3  0.4
2015 Bitencourt RM, Alpár A, Cinquina V, Ferreira SG, Pinheiro BS, Lemos C, Ledent C, Takahashi RN, Sialana FJ, Lubec G, Cunha RA, Harkany T, Köfalvi A. Lack of presynaptic interaction between glucocorticoid and CB1 cannabinoid receptors in GABA- and glutamatergic terminals in the frontal cortex of laboratory rodents. Neurochemistry International. PMID 26196379 DOI: 10.1016/J.Neuint.2015.07.014  0.43
2015 Kaster MP, Machado NJ, Silva HB, Nunes A, Ardais AP, Santana M, Baqi Y, Müller CE, Rodrigues AL, Porciúncula LO, Chen JF, Tomé ÂR, Agostinho P, Canas PM, Cunha RA. Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress. Proceedings of the National Academy of Sciences of the United States of America. 112: 7833-8. PMID 26056314 DOI: 10.1073/Pnas.1423088112  0.421
2015 Madeira MH, Elvas F, Boia R, Gonçalves FQ, Cunha RA, Ambrósio AF, Santiago AR. Adenosine A2AR blockade prevents neuroinflammation-induced death of retinal ganglion cells caused by elevated pressure. Journal of Neuroinflammation. 12: 115. PMID 26054642 DOI: 10.1186/s12974-015-0333-5  0.338
2015 Rodrigues RJ, Tomé AR, Cunha RA. ATP as a multi-target danger signal in the brain. Frontiers in Neuroscience. 9: 148. PMID 25972780 DOI: 10.3389/fnins.2015.00148  0.43
2015 Pagnussat N, Almeida AS, Marques DM, Nunes F, Chenet GC, Botton PH, Mioranzza S, Loss CM, Cunha RA, Porciúncula LO. Adenosine A2 A receptors are necessary and sufficient to trigger memory impairment in adult mice. British Journal of Pharmacology. PMID 25939452 DOI: 10.1111/bph.13180  0.434
2015 Li W, Silva HB, Real J, Wang YM, Rial D, Li P, Payen MP, Zhou Y, Muller CE, Tomé AR, Cunha RA, Chen JF. Inactivation of adenosine A2A receptors reverses working memory deficits at early stages of Huntington's disease models. Neurobiology of Disease. 79: 70-80. PMID 25892655 DOI: 10.1016/J.Nbd.2015.03.030  0.37
2015 Matos M, Shen HY, Augusto E, Wang Y, Wei CJ, Wang YT, Agostinho P, Boison D, Cunha RA, Chen JF. Deletion of Adenosine A2A Receptors from Astrocytes Disrupts Glutamate Homeostasis Leading to Psychomotor and Cognitive Impairment: Relevance to Schizophrenia. Biological Psychiatry. PMID 25869810 DOI: 10.1016/J.Biopsych.2015.02.026  0.351
2015 George J, Gonçalves FQ, Cristóvão G, Rodrigues L, Meyer Fernandes JR, Gonçalves T, Cunha RA, Gomes CA. Different danger signals differently impact on microglial proliferation through alterations of ATP release and extracellular metabolism. Glia. 63: 1636-45. PMID 25847308 DOI: 10.1002/glia.22833  0.354
2015 Lopes JP, Morató X, Souza C, Pinhal C, Machado NJ, Canas PM, Silva HB, Stagljar I, Gandía J, Fernández-Dueñas V, Luján R, Cunha RA, Ciruela F. The role of parkinson's disease-associated receptor GPR37 in the hippocampus: functional interplay with the adenosinergic system. Journal of Neurochemistry. 134: 135-46. PMID 25824528 DOI: 10.1111/Jnc.13109  0.463
2015 Gonçalves FQ, Pires J, Pliassova A, Beleza R, Lemos C, Marques JM, Rodrigues RJ, Canas PM, Köfalvi A, Cunha RA, Rial D. Adenosine A2b receptors control A1 receptor-mediated inhibition of synaptic transmission in the mouse hippocampus. The European Journal of Neuroscience. 41: 878-88. PMID 25704806 DOI: 10.1111/ejn.12851  0.404
2015 Li P, Rial D, Canas PM, Yoo JH, Li W, Zhou X, Wang Y, van Westen GJ, Payen MP, Augusto E, Gonçalves N, Tomé AR, Li Z, Wu Z, Hou X, ... ... Cunha RA, et al. Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory. Molecular Psychiatry. PMID 25687775 DOI: 10.1038/mp.2014.182  0.365
2015 Ribeiro PO, Antunes LM, Nunes CS, Silva HB, Cunha RA, Tomé ÂR. The Effects of Different Concentrations of the α2-Adrenoceptor Agonist Medetomidine on Basal Excitatory Synaptic Transmission and Synaptic Plasticity in Hippocampal Slices of Adult Mice. Anesthesia and Analgesia. 120: 1130-7. PMID 25658314 DOI: 10.1213/ANE.0000000000000636  0.357
2015 Tyebji S, Saavedra A, Canas PM, Pliassova A, Delgado-García JM, Alberch J, Cunha RA, Gruart A, Pérez-Navarro E. Hyperactivation of D1 and A2A receptors contributes to cognitive dysfunction in Huntington's disease. Neurobiology of Disease. 74: 41-57. PMID 25449908 DOI: 10.1016/J.Nbd.2014.11.004  0.396
2015 Ferreira SG, Gonçalves FQ, Marques JM, Tomé ÂR, Rodrigues RJ, Nunes-Correia I, Ledent C, Harkany T, Venance L, Cunha RA, Köfalvi A. Presynaptic adenosine A2A receptors dampen cannabinoid CB1 receptor-mediated inhibition of corticostriatal glutamatergic transmission. British Journal of Pharmacology. 172: 1074-86. PMID 25296982 DOI: 10.1111/Bph.12970  0.468
2015 De Leeuw S, Kerkhofs A, Ferreira S, Cunha R, Mansvelder H. P.1.b.031 The adenosine 1 receptor modulates basal synaptic activity in the pre-frontal cortex European Neuropsychopharmacology. 25: S194-S195. DOI: 10.1016/S0924-977X(15)30193-0  0.391
2014 Rial D, Castro AA, Machado N, Garção P, Gonçalves FQ, Silva HB, Tomé AR, Köfalvi A, Corti O, Raisman-Vozari R, Cunha RA, Prediger RD. Behavioral phenotyping of Parkin-deficient mice: looking for early preclinical features of Parkinson's disease. Plos One. 9: e114216. PMID 25486126 DOI: 10.1371/journal.pone.0114216  0.309
2014 Zappettini S, Grilli M, Olivero G, Chen J, Padolecchia C, Pittaluga A, Tomé AR, Cunha RA, Marchi M. Nicotinic α7 receptor activation selectively potentiates the function of NMDA receptors in glutamatergic terminals of the nucleus accumbens. Frontiers in Cellular Neuroscience. 8: 332. PMID 25360085 DOI: 10.3389/fncel.2014.00332  0.39
2014 Ribeiro PO, Silva HB, Tomé AR, Cunha RA, Antunes LM. Hippocampal long-term potentiation in adult mice after recovery from ketamine anesthesia. Lab Animal. 43: 353-7. PMID 25238524 DOI: 10.1038/laban.571  0.311
2014 Rial D, Lara DR, Cunha RA. The adenosine neuromodulation system in schizophrenia. International Review of Neurobiology. 119: 395-449. PMID 25175974 DOI: 10.1016/B978-0-12-801022-8.00016-7  0.409
2014 Santiago AR, Baptista FI, Santos PF, Cristóvão G, Ambrósio AF, Cunha RA, Gomes CA. Role of microglia adenosine A(2A) receptors in retinal and brain neurodegenerative diseases. Mediators of Inflammation. 2014: 465694. PMID 25132733 DOI: 10.1155/2014/465694  0.388
2014 Coelho JE, Alves P, Canas PM, Valadas JS, Shmidt T, Batalha VL, Ferreira DG, Ribeiro JA, Bader M, Cunha RA, do Couto FS, Lopes LV. Overexpression of Adenosine A2A Receptors in Rats: Effects on Depression, Locomotion, and Anxiety. Frontiers in Psychiatry. 5: 67. PMID 24982640 DOI: 10.3389/fpsyt.2014.00067  0.355
2014 Rial D, Pandolfo P, Bitencourt RM, Pamplona FA, Moreira KM, Hipolide D, Dombrowski PA, Da Cunha C, Walz R, Cunha RA, Takahashi RN, Prediger RD. Cellular prion protein (PrP(C)) modulates ethanol-induced behavioral adaptive changes in mice. Behavioural Brain Research. 271: 325-32. PMID 24975422 DOI: 10.1016/J.Bbr.2014.05.067  0.353
2014 Rial D, Pamplona FA, Moreira EL, Moreira KM, Hipolide D, Rodrigues DI, Dombrowski PA, Da Cunha C, Agostinho P, Takahashi RN, Walz R, Cunha RA, Prediger RD. Cellular prion protein is present in dopaminergic neurons and modulates the dopaminergic system. The European Journal of Neuroscience. 40: 2479-86. PMID 24766164 DOI: 10.1111/Ejn.12600  0.329
2014 Ardais AP, Borges MF, Rocha AS, Sallaberry C, Cunha RA, Porciúncula LO. Caffeine triggers behavioral and neurochemical alterations in adolescent rats. Neuroscience. 270: 27-39. PMID 24726984 DOI: 10.1016/j.neuroscience.2014.04.003  0.359
2014 Ribeiro PO, Tomé AR, Silva HB, Cunha RA, Antunes LM. Clinically relevant concentrations of ketamine mainly affect long-term potentiation rather than basal excitatory synaptic transmission and do not change paired-pulse facilitation in mouse hippocampal slices. Brain Research. 1560: 10-7. PMID 24637258 DOI: 10.1016/j.brainres.2014.03.004  0.34
2014 Garção P, Oliveira CR, Cunha RA, Agostinho P. Subsynaptic localization of nicotinic acetylcholine receptor subunits: a comparative study in the mouse and rat striatum. Neuroscience Letters. 566: 106-10. PMID 24607281 DOI: 10.1016/j.neulet.2014.02.018  0.405
2014 Rodrigues DI, Gutierres J, Pliássova A, Oliveira CR, Cunha RA, Agostinho P. Synaptic and sub-synaptic localization of amyloid-β protein precursor in the rat hippocampus. Journal of Alzheimer's Disease : Jad. 40: 981-92. PMID 24531160 DOI: 10.3233/JAD-132030  0.351
2014 Carmo MR, Menezes AP, Nunes AC, Pliássova A, Rolo AP, Palmeira CM, Cunha RA, Canas PM, Andrade GM. The P2X7 receptor antagonist Brilliant Blue G attenuates contralateral rotations in a rat model of Parkinsonism through a combined control of synaptotoxicity, neurotoxicity and gliosis. Neuropharmacology. 81: 142-52. PMID 24508709 DOI: 10.1016/j.neuropharm.2014.01.045  0.381
2014 Salamone A, Zappettini S, Grilli M, Olivero G, Agostinho P, Tomé AR, Chen J, Pittaluga A, Cunha RA, Marchi M. Prolonged nicotine exposure down-regulates presynaptic NMDA receptors in dopaminergic terminals of the rat nucleus accumbens. Neuropharmacology. 79: 488-97. PMID 24373903 DOI: 10.1016/j.neuropharm.2013.12.014  0.408
2014 Carmo MR, Simões AP, Fonteles AA, Souza CM, Cunha RA, Andrade GM. ATP P2Y1 receptors control cognitive deficits and neurotoxicity but not glial modifications induced by brain ischemia in mice. The European Journal of Neuroscience. 39: 614-22. PMID 24304101 DOI: 10.1111/ejn.12435  0.392
2014 Canas PM, Simões AP, Rodrigues RJ, Cunha RA. Predominant loss of glutamatergic terminal markers in a β-amyloid peptide model of Alzheimer's disease. Neuropharmacology. 76: 51-6. PMID 24029236 DOI: 10.1016/j.neuropharm.2013.08.026  0.327
2014 Wei CJ, Augusto E, Gomes CA, Singer P, Wang Y, Boison D, Cunha RA, Yee BK, Chen JF. Regulation of fear responses by striatal and extrastriatal adenosine A2A receptors in forebrain. Biological Psychiatry. 75: 855-63. PMID 23820821 DOI: 10.1016/J.Biopsych.2013.05.003  0.416
2014 Saavedra A, Tyebji S, Canas P, Pliassova A, Delgado-Garcia J, Alberch J, Cunha R, Gruart A, Perez-Navarro E. M16 D1R and A2AR Blockade Normalises PKA Activity and Improves Hippocampal-dependent Cognitive Dysfunction but not Motor Deficits in Huntington's Disease Journal of Neurology, Neurosurgery & Psychiatry. 85: A99-A100. DOI: 10.1136/Jnnp-2014-309032.288  0.356
2013 Shen HY, Canas PM, Garcia-Sanz P, Lan JQ, Boison D, Moratalla R, Cunha RA, Chen JF. Adenosine Aâ‚‚A receptors in striatal glutamatergic terminals and GABAergic neurons oppositely modulate psychostimulant action and DARPP-32 phosphorylation. Plos One. 8: e80902. PMID 24312250 DOI: 10.1371/Journal.Pone.0080902  0.39
2013 Matos M, Augusto E, Agostinho P, Cunha RA, Chen JF. Antagonistic interaction between adenosine A2A receptors and Na+/K+-ATPase-α2 controlling glutamate uptake in astrocytes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 18492-502. PMID 24259572 DOI: 10.1523/Jneurosci.1828-13.2013  0.371
2013 Silva CG, Métin C, Fazeli W, Machado NJ, Darmopil S, Launay PS, Ghestem A, Nesa MP, Bassot E, Szabó E, Baqi Y, Müller CE, Tomé AR, Ivanov A, Isbrandt D, ... ... Cunha RA, et al. Adenosine receptor antagonists including caffeine alter fetal brain development in mice. Science Translational Medicine. 5: 197ra104. PMID 23926202 DOI: 10.1126/Scitranslmed.3006258  0.422
2013 Soares E, Prediger RD, Nunes S, Castro AA, Viana SD, Lemos C, De Souza CM, Agostinho P, Cunha RA, Carvalho E, Fontes Ribeiro CA, Reis F, Pereira FC. Spatial memory impairments in a prediabetic rat model. Neuroscience. 250: 565-77. PMID 23912035 DOI: 10.1016/j.neuroscience.2013.07.055  0.409
2013 Augusto E, Matos M, Sévigny J, El-Tayeb A, Bynoe MS, Müller CE, Cunha RA, Chen JF. Ecto-5'-nucleotidase (CD73)-mediated formation of adenosine is critical for the striatal adenosine A2A receptor functions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 11390-9. PMID 23843511 DOI: 10.1523/Jneurosci.5817-12.2013  0.327
2013 Garção P, Szabó EC, Wopereis S, Castro AA, Tomé ÂR, Prediger RD, Cunha RA, Agostinho P, Köfalvi A. Functional interaction between pre-synaptic α6β2-containing nicotinic and adenosine A2A receptors in the control of dopamine release in the rat striatum. British Journal of Pharmacology. 169: 1600-11. PMID 23638679 DOI: 10.1111/bph.12234  0.394
2013 Gonçalves N, Simões AT, Cunha RA, de Almeida LP. Caffeine and adenosine A(2A) receptor inactivation decrease striatal neuropathology in a lentiviral-based model of Machado-Joseph disease. Annals of Neurology. 73: 655-66. PMID 23625556 DOI: 10.1002/ana.23866  0.404
2013 Gomes C, Ferreira R, George J, Sanches R, Rodrigues DI, Gonçalves N, Cunha RA. Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A2A receptor-dependent manner: A2A receptor blockade prevents BDNF release and proliferation of microglia. Journal of Neuroinflammation. 10: 16. PMID 23363775 DOI: 10.1186/1742-2094-10-16  0.347
2013 Espinosa J, Rocha A, Nunes F, Costa MS, Schein V, Kazlauckas V, Kalinine E, Souza DO, Cunha RA, Porciúncula LO. Caffeine consumption prevents memory impairment, neuronal damage, and adenosine A2A receptors upregulation in the hippocampus of a rat model of sporadic dementia. Journal of Alzheimer's Disease : Jad. 34: 509-18. PMID 23241554 DOI: 10.3233/JAD-111982  0.437
2013 Pandolfo P, Machado NJ, Köfalvi A, Takahashi RN, Cunha RA. Caffeine regulates frontocorticostriatal dopamine transporter density and improves attention and cognitive deficits in an animal model of attention deficit hyperactivity disorder. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 23: 317-28. PMID 22561003 DOI: 10.1016/J.Euroneuro.2012.04.011  0.334
2013 Marchi M, Salamone A, Zappettini S, Grilli M, Olivero G, Chen J, Cunha R, Pittaluga A. In vitro exposure to nicotine modulate the function of presynaptic NMDA receptors present on dopaminergic terminals in rat Nucleus Accumbens Biochemical Pharmacology. 86: 1228. DOI: 10.1016/j.bcp.2013.08.039  0.386
2012 Simões AP, Duarte JA, Agasse F, Canas PM, Tomé AR, Agostinho P, Cunha RA. Blockade of adenosine A2A receptors prevents interleukin-1β-induced exacerbation of neuronal toxicity through a p38 mitogen-activated protein kinase pathway. Journal of Neuroinflammation. 9: 204. PMID 22901528 DOI: 10.1186/1742-2094-9-204  0.349
2012 Matos M, Augusto E, Machado NJ, dos Santos-Rodrigues A, Cunha RA, Agostinho P. Astrocytic adenosine A2A receptors control the amyloid-β peptide-induced decrease of glutamate uptake. Journal of Alzheimer's Disease : Jad. 31: 555-67. PMID 22647260 DOI: 10.3233/JAD-2012-120469  0.409
2012 Duarte JM, Agostinho PM, Carvalho RA, Cunha RA. Caffeine consumption prevents diabetes-induced memory impairment and synaptotoxicity in the hippocampus of NONcZNO10/LTJ mice. Plos One. 7: e21899. PMID 22514596 DOI: 10.1371/Journal.Pone.0021899  0.723
2012 Matos M, Augusto E, Santos-Rodrigues AD, Schwarzschild MA, Chen JF, Cunha RA, Agostinho P. Adenosine A2A receptors modulate glutamate uptake in cultured astrocytes and gliosomes. Glia. 60: 702-16. PMID 22298379 DOI: 10.1002/Glia.22290  0.413
2012 Duarte JM, Ferreira SG, Carvalho RA, Cunha RA, Köfalvi A. CB₁ receptor activation inhibits neuronal and astrocytic intermediary metabolism in the rat hippocampus. Neurochemistry International. 60: 1-8. PMID 22085448 DOI: 10.1016/J.Neuint.2011.10.019  0.728
2011 Costenla AR, Diógenes MJ, Canas PM, Rodrigues RJ, Nogueira C, Maroco J, Agostinho PM, Ribeiro JA, Cunha RA, de Mendonça A. Enhanced role of adenosine A(2A) receptors in the modulation of LTP in the rat hippocampus upon ageing. The European Journal of Neuroscience. 34: 12-21. PMID 21615561 DOI: 10.1111/j.1460-9568.2011.07719.x  0.37
2011 Musante V, Summa M, Cunha RA, Raiteri M, Pittaluga A. Pre-synaptic glycine GlyT1 transporter--NMDA receptor interaction: relevance to NMDA autoreceptor activation in the presence of Mg2+ ions. Journal of Neurochemistry. 117: 516-27. PMID 21348870 DOI: 10.1111/j.1471-4159.2011.07223.x  0.373
2011 Pandolfo P, Silveirinha V, dos Santos-Rodrigues A, Venance L, Ledent C, Takahashi RN, Cunha RA, Köfalvi A. Cannabinoids inhibit the synaptic uptake of adenosine and dopamine in the rat and mouse striatum. European Journal of Pharmacology. 655: 38-45. PMID 21266173 DOI: 10.1016/J.Ejphar.2011.01.013  0.442
2011 Rebola N, Simões AP, Canas PM, Tomé AR, Andrade GM, Barry CE, Agostinho PM, Lynch MA, Cunha RA. Adenosine A2A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction. Journal of Neurochemistry. 117: 100-11. PMID 21235574 DOI: 10.1111/j.1471-4159.2011.07178.x  0.385
2011 Gomes CV, Kaster MP, Tomé AR, Agostinho PM, Cunha RA. Adenosine receptors and brain diseases: neuroprotection and neurodegeneration. Biochimica Et Biophysica Acta. 1808: 1380-99. PMID 21145878 DOI: 10.1016/J.Bbamem.2010.12.001  0.457
2011 Martire A, Tebano MT, Chiodi V, Ferreira SG, Cunha RA, Köfalvi A, Popoli P. Pre-synaptic adenosine A2A receptors control cannabinoid CB1 receptor-mediated inhibition of striatal glutamatergic neurotransmission. Journal of Neurochemistry. 116: 273-80. PMID 21062287 DOI: 10.1111/j.1471-4159.2010.07101.x  0.457
2010 Gaspar JM, Baptista FI, Galvão J, Castilho AF, Cunha RA, Ambrósio AF. Diabetes differentially affects the content of exocytotic proteins in hippocampal and retinal nerve terminals. Neuroscience. 169: 1589-600. PMID 20600668 DOI: 10.1016/j.neuroscience.2010.06.021  0.336
2010 de Mendonça A, Cunha RA. Therapeutic opportunities for caffeine in Alzheimer's disease and other neurodegenerative disorders. Journal of Alzheimer's Disease : Jad. 20: S1-2. PMID 20448305 DOI: 10.3233/JAD-2010-01420  0.319
2010 Cunha RA, Agostinho PM. Chronic caffeine consumption prevents memory disturbance in different animal models of memory decline. Journal of Alzheimer's Disease : Jad. 20: S95-116. PMID 20182043 DOI: 10.3233/JAD-2010-1408  0.371
2010 Costenla AR, Cunha RA, de Mendonça A. Caffeine, adenosine receptors, and synaptic plasticity. Journal of Alzheimer's Disease : Jad. 20: S25-34. PMID 20182030 DOI: 10.3233/JAD-2010-091384  0.498
2010 Cognato GP, Agostinho PM, Hockemeyer J, Müller CE, Souza DO, Cunha RA. Caffeine and an adenosine A(2A) receptor antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life. Journal of Neurochemistry. 112: 453-62. PMID 19878534 DOI: 10.1111/J.1471-4159.2009.06465.X  0.433
2010 Tomé ÂR, Silva H, Cunha RA. Role of The Purinergic Neuromodulation System in Epilepsy The Open Neuroscience Journal. 4: 64-83. DOI: 10.2174/1874082001004010064  0.379
2009 Canas PM, Porciúncula LO, Cunha GM, Silva CG, Machado NJ, Oliveira JM, Oliveira CR, Cunha RA. Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38 mitogen-activated protein kinase pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 14741-51. PMID 19940169 DOI: 10.1523/JNEUROSCI.3728-09.2009  0.419
2009 Quiroz C, Luján R, Uchigashima M, Simoes AP, Lerner TN, Borycz J, Kachroo A, Canas PM, Orru M, Schwarzschild MA, Rosin DL, Kreitzer AC, Cunha RA, Watanabe M, Ferré S. Key modulatory role of presynaptic adenosine A2A receptors in cortical neurotransmission to the striatal direct pathway. Thescientificworldjournal. 9: 1321-44. PMID 19936569 DOI: 10.1100/Tsw.2009.143  0.669
2009 Duarte JM, Carvalho RA, Cunha RA, Gruetter R. Caffeine consumption attenuates neurochemical modifications in the hippocampus of streptozotocin-induced diabetic rats. Journal of Neurochemistry. 111: 368-79. PMID 19694901 DOI: 10.1111/J.1471-4159.2009.06349.X  0.755
2009 Velloso NA, Dalmolin GD, Gomes GM, Rubin MA, Canas PM, Cunha RA, Mello CF. Spermine improves recognition memory deficit in a rodent model of Huntington's disease. Neurobiology of Learning and Memory. 92: 574-80. PMID 19632348 DOI: 10.1016/j.nlm.2009.07.006  0.315
2009 Gomes CA, Simões PF, Canas PM, Quiroz C, Sebastião AM, Ferré S, Cunha RA, Ribeiro JA. GDNF control of the glutamatergic cortico-striatal pathway requires tonic activation of adenosine A receptors. Journal of Neurochemistry. 108: 1208-19. PMID 19141075 DOI: 10.1111/J.1471-4159.2009.05876.X  0.498
2009 Ferreira SG, Lomaglio T, Avelino A, Cruz F, Oliveira CR, Cunha RA, Köfalvi A. N-acyldopamines control striatal input terminals via novel ligand-gated cation channels. Neuropharmacology. 56: 676-83. PMID 19101577 DOI: 10.1016/j.neuropharm.2008.12.001  0.381
2009 Canas PM, Duarte JM, Rodrigues RJ, Köfalvi A, Cunha RA. Modification upon aging of the density of presynaptic modulation systems in the hippocampus. Neurobiology of Aging. 30: 1877-84. PMID 18304697 DOI: 10.1016/j.neurobiolaging.2008.01.003  0.677
2008 Cunha RA, Ferré S, Vaugeois JM, Chen JF. Potential therapeutic interest of adenosine A2A receptors in psychiatric disorders. Current Pharmaceutical Design. 14: 1512-24. PMID 18537674 DOI: 10.2174/138161208784480090  0.466
2008 Ferré S, Quiroz C, Woods AS, Cunha R, Popoli P, Ciruela F, Lluis C, Franco R, Azdad K, Schiffmann SN. An update on adenosine A2A-dopamine D2 receptor interactions: implications for the function of G protein-coupled receptors. Current Pharmaceutical Design. 14: 1468-74. PMID 18537670 DOI: 10.2174/138161208784480108  0.419
2008 Donato R, Rodrigues RJ, Takahashi M, Tsai MC, Soto D, Miyagi K, Villafuertes RG, Cunha RA, Edwards FA. GABA release by basket cells onto Purkinje cells, in rat cerebellar slices, is directly controlled by presynaptic purinergic receptors, modulating Ca2+ influx. Cell Calcium. 44: 521-32. PMID 18468677 DOI: 10.1016/j.ceca.2008.03.006  0.453
2008 Silva AM, Rodrigues RJ, Tomé AR, Cunha RA, Misler S, Rosário LM, Santos RM. Electrophysiological and immunocytochemical evidence for P2X purinergic receptors in pancreatic beta cells. Pancreas. 36: 279-83. PMID 18362842 DOI: 10.1097/Mpa.0B013E31815A8473  0.331
2008 Shen HY, Coelho JE, Ohtsuka N, Canas PM, Day YJ, Huang QY, Rebola N, Yu L, Boison D, Cunha RA, Linden J, Tsien JZ, Chen JF. A critical role of the adenosine A2A receptor in extrastriatal neurons in modulating psychomotor activity as revealed by opposite phenotypes of striatum and forebrain A2A receptor knock-outs. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 2970-5. PMID 18354001 DOI: 10.1523/Jneurosci.5255-07.2008  0.387
2008 Yu L, Shen HY, Coelho JE, Araújo IM, Huang QY, Day YJ, Rebola N, Canas PM, Rapp EK, Ferrara J, Taylor D, Müller CE, Linden J, Cunha RA, Chen JF. Adenosine A2A receptor antagonists exert motor and neuroprotective effects by distinct cellular mechanisms. Annals of Neurology. 63: 338-46. PMID 18300283 DOI: 10.1002/Ana.21313  0.398
2008 Cunha GM, Canas PM, Melo CS, Hockemeyer J, Müller CE, Oliveira CR, Cunha RA. Adenosine A2A receptor blockade prevents memory dysfunction caused by beta-amyloid peptides but not by scopolamine or MK-801. Experimental Neurology. 210: 776-81. PMID 18191838 DOI: 10.1016/J.Expneurol.2007.11.013  0.408
2008 Rebola N, Lujan R, Cunha RA, Mulle C. Adenosine A2A receptors are essential for long-term potentiation of NMDA-EPSCs at hippocampal mossy fiber synapses. Neuron. 57: 121-34. PMID 18184569 DOI: 10.1016/J.Neuron.2007.11.023  0.414
2008 Cunha RA. Different cellular sources and different roles of adenosine: A1 receptor-mediated inhibition through astrocytic-driven volume transmission and synapse-restricted A2A receptor-mediated facilitation of plasticity. Neurochemistry International. 52: 65-72. PMID 17664029 DOI: 10.1016/j.neuint.2007.06.026  0.492
2008 Rodrigues RJ, Canas PM, Lopes LV, Oliveira CR, Cunha RA. Modification of adenosine modulation of acetylcholine release in the hippocampus of aged rats. Neurobiology of Aging. 29: 1597-601. PMID 17481781 DOI: 10.1016/j.neurobiolaging.2007.03.025  0.423
2007 Ferré S, Ciruela F, Quiroz C, Luján R, Popoli P, Cunha RA, Agnati LF, Fuxe K, Woods AS, Lluis C, Franco R. Adenosine receptor heteromers and their integrative role in striatal function. Thescientificworldjournal. 7: 74-85. PMID 17982579 DOI: 10.1100/Tsw.2007.211  0.455
2007 Duarte JM, Oses JP, Rodrigues RJ, Cunha RA. Modification of purinergic signaling in the hippocampus of streptozotocin-induced diabetic rats. Neuroscience. 149: 382-91. PMID 17869435 DOI: 10.1016/j.neuroscience.2007.08.005  0.415
2007 Schiffmann SN, Fisone G, Moresco R, Cunha RA, Ferré S. Adenosine A2A receptors and basal ganglia physiology. Progress in Neurobiology. 83: 277-92. PMID 17646043 DOI: 10.1016/J.Pneurobio.2007.05.001  0.478
2007 Silva CG, Porciúncula LO, Canas PM, Oliveira CR, Cunha RA. Blockade of adenosine A(2A) receptors prevents staurosporine-induced apoptosis of rat hippocampal neurons. Neurobiology of Disease. 27: 182-9. PMID 17596953 DOI: 10.1016/j.nbd.2007.04.018  0.428
2007 Köfalvi A, Pereira MF, Rebola N, Rodrigues RJ, Oliveira CR, Cunha RA. Anandamide and NADA bi-directionally modulate presynaptic Ca2+ levels and transmitter release in the hippocampus. British Journal of Pharmacology. 151: 551-63. PMID 17435795 DOI: 10.1038/sj.bjp.0707252  0.381
2007 Rebola N, Sachidhanandam S, Perrais D, Cunha RA, Mulle C. Short-term plasticity of kainate receptor-mediated EPSCs induced by NMDA receptors at hippocampal mossy fiber synapses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 3987-93. PMID 17428973 DOI: 10.1523/Jneurosci.5182-06.2007  0.423
2007 Borycz J, Pereira MF, Melani A, Rodrigues RJ, Köfalvi A, Panlilio L, Pedata F, Goldberg SR, Cunha RA, Ferré S. Differential glutamate-dependent and glutamate-independent adenosine A1 receptor-mediated modulation of dopamine release in different striatal compartments. Journal of Neurochemistry. 101: 355-63. PMID 17254024 DOI: 10.1111/j.1471-4159.2006.04386.x  0.638
2007 Duarte JM, Nogueira C, Mackie K, Oliveira CR, Cunha RA, Köfalvi A. Increase of cannabinoid CB1 receptor density in the hippocampus of streptozotocin-induced diabetic rats. Experimental Neurology. 204: 479-84. PMID 17222407 DOI: 10.1016/j.expneurol.2006.11.013  0.683
2007 Duarte JM, Cunha RA, Carvalho RA. Different metabolism of glutamatergic and GABAergic compartments in superfused hippocampal slices characterized by nuclear magnetic resonance spectroscopy. Neuroscience. 144: 1305-13. PMID 17197104 DOI: 10.1016/J.Neuroscience.2006.11.027  0.549
2007 Dall'Igna OP, Fett P, Gomes MW, Souza DO, Cunha RA, Lara DR. Caffeine and adenosine A(2a) receptor antagonists prevent beta-amyloid (25-35)-induced cognitive deficits in mice. Experimental Neurology. 203: 241-5. PMID 17007839 DOI: 10.1016/j.expneurol.2006.08.008  0.414
2007 Duarte JN, Carvalho RA, Cunha RA. Caffeine consumption prevents hippocampal alterations in type 2 diabetic mice Journal of Neurochemistry. 102: 215. DOI: 10.1111/J.0022-3042.2007.04729.X  0.536
2006 Rodrigues RJ, Almeida T, de Mendonça A, Cunha RA. Interaction between P2X and nicotinic acetylcholine receptors in glutamate nerve terminals of the rat hippocampus. Journal of Molecular Neuroscience : Mn. 30: 173-6. PMID 17192669 DOI: 10.1385/JMN:30:1:173  0.344
2006 Ciruela F, Ferré S, Casadó V, Cortés A, Cunha RA, Lluis C, Franco R. Heterodimeric adenosine receptors: a device to regulate neurotransmitter release. Cellular and Molecular Life Sciences : Cmls. 63: 2427-31. PMID 17058035 DOI: 10.1007/S00018-006-6216-2  0.446
2006 Degroot A, Köfalvi A, Wade MR, Davis RJ, Rodrigues RJ, Rebola N, Cunha RA, Nomikos GG. CB1 receptor antagonism increases hippocampal acetylcholine release: site and mechanism of action. Molecular Pharmacology. 70: 1236-45. PMID 16855179 DOI: 10.1124/mol.106.024661  0.461
2006 Cunha GM, Canas PM, Oliveira CR, Cunha RA. Increased density and synapto-protective effect of adenosine A2A receptors upon sub-chronic restraint stress. Neuroscience. 141: 1775-81. PMID 16797134 DOI: 10.1016/j.neuroscience.2006.05.024  0.448
2006 Köfalvi A, Oliveira CR, Cunha RA. Lack of evidence for functional TRPV1 vanilloid receptors in rat hippocampal nerve terminals. Neuroscience Letters. 403: 151-6. PMID 16672175 DOI: 10.1016/j.neulet.2006.04.030  0.387
2006 Ciruela F, Casadó V, Rodrigues RJ, Luján R, Burgueño J, Canals M, Borycz J, Rebola N, Goldberg SR, Mallol J, Cortés A, Canela EI, López-Giménez JF, Milligan G, Lluis C, ... Cunha RA, et al. Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 2080-7. PMID 16481441 DOI: 10.1523/Jneurosci.3574-05.2006  0.474
2006 Pereira DB, Rebola N, Rodrigues RJ, Cunha RA, Carvalho AP, Duarte CB. Trkb receptors modulation of glutamate release is limited to a subset of nerve terminals in the adult rat hippocampus. Journal of Neuroscience Research. 83: 832-44. PMID 16477614 DOI: 10.1002/Jnr.20784  0.411
2006 Coelho JE, Rebola N, Fragata I, Ribeiro JA, de Mendonça A, Cunha RA. Hypoxia-induced desensitization and internalization of adenosine A1 receptors in the rat hippocampus. Neuroscience. 138: 1195-203. PMID 16442739 DOI: 10.1016/j.neuroscience.2005.12.012  0.484
2006 Duarte JM, Oliveira CR, Ambrósio AF, Cunha RA. Modification of adenosine A1 and A2A receptor density in the hippocampus of streptozotocin-induced diabetic rats. Neurochemistry International. 48: 144-50. PMID 16256246 DOI: 10.1016/j.neuint.2005.08.008  0.712
2005 Cunha RA. Neuroprotection by adenosine in the brain: From A(1) receptor activation to A (2A) receptor blockade. Purinergic Signalling. 1: 111-34. PMID 18404497 DOI: 10.1007/s11302-005-0649-1  0.413
2005 Ferré S, Borycz J, Goldberg SR, Hope BT, Morales M, Lluis C, Franco R, Ciruela F, Cunha R. Role of adenosine in the control of homosynaptic plasticity in striatal excitatory synapses. Journal of Integrative Neuroscience. 4: 445-64. PMID 16385640 DOI: 10.1142/S0219635205000987  0.368
2005 Tebano MT, Martire A, Rebola N, Pepponi R, Domenici MR, Grò MC, Schwarzschild MA, Chen JF, Cunha RA, Popoli P. Adenosine A2A receptors and metabotropic glutamate 5 receptors are co-localized and functionally interact in the hippocampus: a possible key mechanism in the modulation of N-methyl-D-aspartate effects. Journal of Neurochemistry. 95: 1188-200. PMID 16271052 DOI: 10.1111/J.1471-4159.2005.03455.X  0.486
2005 Rebola N, Rodrigues RJ, Oliveira CR, Cunha RA. Different roles of adenosine A1, A2A and A3 receptors in controlling kainate-induced toxicity in cortical cultured neurons. Neurochemistry International. 47: 317-25. PMID 16011860 DOI: 10.1016/j.neuint.2005.05.009  0.465
2005 Rodrigues RJ, Almeida T, Richardson PJ, Oliveira CR, Cunha RA. Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y1, P2Y2, and/or P2Y4 receptors in the rat hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 6286-95. PMID 16000618 DOI: 10.1523/JNEUROSCI.0628-05.2005  0.474
2005 Rebola N, Porciúncula LO, Lopes LV, Oliveira CR, Soares-da-Silva P, Cunha RA. Long-term effect of convulsive behavior on the density of adenosine A1 and A 2A receptors in the rat cerebral cortex. Epilepsia. 46: 159-65. PMID 15987272 DOI: 10.1111/j.1528-1167.2005.01026.x  0.432
2005 Rebola N, Rodrigues RJ, Lopes LV, Richardson PJ, Oliveira CR, Cunha RA. Adenosine A1 and A2A receptors are co-expressed in pyramidal neurons and co-localized in glutamatergic nerve terminals of the rat hippocampus. Neuroscience. 133: 79-83. PMID 15893632 DOI: 10.1016/j.neuroscience.2005.01.054  0.476
2005 Rebola N, Canas PM, Oliveira CR, Cunha RA. Different synaptic and subsynaptic localization of adenosine A2A receptors in the hippocampus and striatum of the rat. Neuroscience. 132: 893-903. PMID 15857695 DOI: 10.1016/j.neuroscience.2005.01.014  0.485
2005 Pinto-Duarte A, Coelho JE, Cunha RA, Ribeiro JA, Sebastião AM. Adenosine A2A receptors control the extracellular levels of adenosine through modulation of nucleoside transporters activity in the rat hippocampus. Journal of Neurochemistry. 93: 595-604. PMID 15836618 DOI: 10.1111/J.1471-4159.2005.03071.X  0.487
2005 Fredholm BB, Chen JF, Cunha RA, Svenningsson P, Vaugeois JM. Adenosine and brain function. International Review of Neurobiology. 63: 191-270. PMID 15797469 DOI: 10.1016/S0074-7742(05)63007-3  0.663
2005 Köfalvi A, Rodrigues RJ, Ledent C, Mackie K, Vizi ES, Cunha RA, Sperlágh B. Involvement of cannabinoid receptors in the regulation of neurotransmitter release in the rodent striatum: a combined immunochemical and pharmacological analysis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 2874-84. PMID 15772347 DOI: 10.1523/Jneurosci.4232-04.2005  0.437
2005 Rodrigues RJ, Alfaro TM, Rebola N, Oliveira CR, Cunha RA. Co-localization and functional interaction between adenosine A(2A) and metabotropic group 5 receptors in glutamatergic nerve terminals of the rat striatum. Journal of Neurochemistry. 92: 433-41. PMID 15659214 DOI: 10.1111/j.1471-4159.2004.02887.x  0.472
2004 Halldner L, Lopes LV, Daré E, Lindström K, Johansson B, Ledent C, Cunha RA, Fredholm BB. Binding of adenosine receptor ligands to brain of adenosine receptor knock-out mice: evidence that CGS 21680 binds to A1 receptors in hippocampus. Naunyn-Schmiedeberg's Archives of Pharmacology. 370: 270-8. PMID 15378230 DOI: 10.1007/s00210-004-0970-1  0.575
2004 Alfaro TM, Vigia E, Oliveira CR, Cunha RA. Effect of free radicals on adenosine A(2A) and dopamine D2 receptors in the striatum of young adult and aged rats. Neurochemistry International. 45: 733-8. PMID 15234116 DOI: 10.1016/j.neuint.2004.02.003  0.425
2004 Lopes LV, Halldner L, Rebola N, Johansson B, Ledent C, Chen JF, Fredholm BB, Cunha RA. Binding of the prototypical adenosine A(2A) receptor agonist CGS 21680 to the cerebral cortex of adenosine A(1) and A(2A) receptor knockout mice. British Journal of Pharmacology. 141: 1006-14. PMID 14993095 DOI: 10.1038/sj.bjp.0705692  0.576
2004 Cunha RA, Ribeiro JA, Malva JO. Presynaptic kainate receptors modulating glutamatergic transmission in the rat hippocampus are inhibited by arachidonic acid. Neurochemistry International. 44: 371-9. PMID 14643755 DOI: 10.1016/S0197-0186(03)00167-0  0.488
2003 Almeida T, Rodrigues RJ, de Mendonça A, Ribeiro JA, Cunha RA. Purinergic P2 receptors trigger adenosine release leading to adenosine A2A receptor activation and facilitation of long-term potentiation in rat hippocampal slices. Neuroscience. 122: 111-21. PMID 14596853 DOI: 10.1016/S0306-4522(03)00523-2  0.448
2003 Malva JO, Silva AP, Cunha RA. Presynaptic modulation controlling neuronal excitability and epileptogenesis: role of kainate, adenosine and neuropeptide Y receptors. Neurochemical Research. 28: 1501-15. PMID 14570395 DOI: 10.1023/A:1025618324593  0.431
2003 Lopes LV, Rebola N, Pinheiro PC, Richardson PJ, Oliveira CR, Cunha RA. Adenosine A3 receptors are located in neurons of the rat hippocampus. Neuroreport. 14: 1645-8. PMID 14502093 DOI: 10.1097/01.wnr.0000088406.04452.44  0.457
2003 Rebola N, Pinheiro PC, Oliveira CR, Malva JO, Cunha RA. Subcellular localization of adenosine A(1) receptors in nerve terminals and synapses of the rat hippocampus. Brain Research. 987: 49-58. PMID 14499945 DOI: 10.1016/S0006-8993(03)03247-5  0.464
2003 Rebola N, Coelho JE, Costenla AR, Lopes LV, Parada A, Oliveira CR, Soares-da-Silva P, de Mendonça A, Cunha RA. Decrease of adenosine A1 receptor density and of adenosine neuromodulation in the hippocampus of kindled rats. The European Journal of Neuroscience. 18: 820-8. PMID 12925008 DOI: 10.1046/j.1460-9568.2003.02815.x  0.494
2003 Rebola N, Sebastião AM, de Mendonca A, Oliveira CR, Ribeiro JA, Cunha RA. Enhanced adenosine A2A receptor facilitation of synaptic transmission in the hippocampus of aged rats. Journal of Neurophysiology. 90: 1295-303. PMID 12904509 DOI: 10.1152/Jn.00896.2002  0.487
2003 Cunha RA. Heteroexchange of purines in the hippocampus: mixing-up or messing-up ATP and adenosine. British Journal of Pharmacology. 139: 473-4. PMID 12788806 DOI: 10.1038/sj.bjp.0705286  0.376
2003 Dall'Igna OP, Porciúncula LO, Souza DO, Cunha RA, Lara DR, Dall'lgna OP. Neuroprotection by caffeine and adenosine A2A receptor blockade of beta-amyloid neurotoxicity. British Journal of Pharmacology. 138: 1207-9. PMID 12711619 DOI: 10.1038/sj.bjp.0705185  0.465
2003 Magalhães-Cardoso MT, Pereira MF, Oliveira L, Ribeiro JA, Cunha RA, Correia-de-Sá P. Ecto-AMP deaminase blunts the ATP-derived adenosine A2A receptor facilitation of acetylcholine release at rat motor nerve endings. The Journal of Physiology. 549: 399-408. PMID 12679375 DOI: 10.1113/jphysiol.2003.040410  0.403
2003 Almeida CG, de Mendonça A, Cunha RA, Ribeiro JA. Adenosine promotes neuronal recovery from reactive oxygen species induced lesion in rat hippocampal slices. Neuroscience Letters. 339: 127-30. PMID 12614911 DOI: 10.1016/S0304-3940(02)01478-7  0.447
2003 Santos DA, Salgado AI, Cunha RA. ATP is released from nerve terminals and from activated muscle fibres on stimulation of the rat phrenic nerve. Neuroscience Letters. 338: 225-8. PMID 12581837 DOI: 10.1016/S0304-3940(02)01419-2  0.368
2003 Fredholm BB, Cunha RA, Svenningsson P. Pharmacology of adenosine A2A receptors and therapeutic applications. Current Topics in Medicinal Chemistry. 3: 413-26. PMID 12570759 DOI: 10.2174/1568026033392200  0.668
2003 Pinheiro PS, Rodrigues RJ, Silva AP, Cunha RA, Oliveira CR, Malva JO. Solubilization and immunological identification of presynaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in the rat hippocampus. Neuroscience Letters. 336: 97-100. PMID 12499049 DOI: 10.1016/S0304-3940(02)01217-X  0.443
2003 Lopes LV, Rebola N, Costenla AR, Halldner L, Jacobson MA, Oliveira CR, Richardson PJ, Fredholm BB, Ribeiro JA, Cunha RA. Adenosine A3 receptors in the rat hippocampus: Lack of interaction with A1 receptors Drug Development Research. 58: 428-438. DOI: 10.1002/ddr.10188  0.611
2002 Rebola N, Oliveira CR, Cunha RA. Transducing system operated by adenosine A(2A) receptors to facilitate acetylcholine release in the rat hippocampus. European Journal of Pharmacology. 454: 31-8. PMID 12409002 DOI: 10.1016/S0014-2999(02)02475-5  0.476
2002 Cunha RA, Coelho JE, Costenla AR, Lopes LV, Parada A, de Mendonça A, Sebastião AM, Ribeiro JA. Effects of carbamazepine and novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives on synaptic transmission in rat hippocampal slices. Pharmacology & Toxicology. 90: 208-13. PMID 12076316 DOI: 10.1034/J.1600-0773.2002.900407.X  0.402
2002 Lopes LV, Cunha RA, Kull B, Fredholm BB, Ribeiro JA. Adenosine A(2A) receptor facilitation of hippocampal synaptic transmission is dependent on tonic A(1) receptor inhibition. Neuroscience. 112: 319-29. PMID 12044450 DOI: 10.1016/S0306-4522(02)00080-5  0.627
2002 Díaz-Hernández M, Pereira MF, Pintor J, Cunha RA, Ribeiro JA, Miras-Portugal MT. Modulation of the rat hippocampal dinucleotide receptor by adenosine receptor activation. The Journal of Pharmacology and Experimental Therapeutics. 301: 441-50. PMID 11961042 DOI: 10.1124/jpet.301.2.441  0.476
2002 de Brito MT, Canto A, Correia JH, Cunha RA, Marques MC. Adenosine A(2A) receptors in portal hypertension: their role in the abnormal response to adenosine of the cranial mesenteric artery in rabbits. British Journal of Pharmacology. 135: 1324-30. PMID 11877342 DOI: 10.1038/sj.bjp.0704575  0.44
2001 Cunha RA. Regulation of the ecto-nucleotidase pathway in rat hippocampal nerve terminals. Neurochemical Research. 26: 979-91. PMID 11699950 DOI: 10.1023/A:1012392719601  0.407
2001 Bonifácio MJ, Sheridan RD, Parada A, Cunha RA, Patmore L, Soares-da-Silva P. Interaction of the novel anticonvulsant, BIA 2-093, with voltage-gated sodium channels: comparison with carbamazepine. Epilepsia. 42: 600-8. PMID 11380566 DOI: 10.1046/J.1528-1157.2001.43600.X  0.303
2001 Cunha RA, Constantino MD, Fonseca E, Ribeiro JA. Age-dependent decrease in adenosine A1 receptor binding sites in the rat brain. Effect of cis unsaturated free fatty acids. European Journal of Biochemistry / Febs. 268: 2939-47. PMID 11358511 DOI: 10.1046/j.1432-1327.2001.02183.x  0.445
2001 Cunha RA, Almeida T, Ribeiro JA. Parallel modification of adenosine extracellular metabolism and modulatory action in the hippocampus of aged rats. Journal of Neurochemistry. 76: 372-82. PMID 11208900 DOI: 10.1046/j.1471-4159.2001.00095.x  0.475
2001 Cunha RA. Adenosine as a neuromodulator and as a homeostatic regulator in the nervous system: different roles, different sources and different receptors. Neurochemistry International. 38: 107-25. PMID 11137880 DOI: 10.1016/S0197-0186(00)00034-6  0.485
2001 Ribeiro JA, Cunha-Reis D, Lopes LV, Coelho JE, Costenla AR, Correia-de-Sá P, Cunha RA, De Mendonça A, Sebastiao AM. Adenosine receptor interactions in the hippocampus Drug Development Research. 52: 337-345. DOI: 10.1002/Ddr.1132  0.455
2000 Cunha RA, Ribeiro JA. ATP as a presynaptic modulator. Life Sciences. 68: 119-37. PMID 11191632 DOI: 10.1016/S0024-3205(00)00923-1  0.416
2000 Sebastião AM, Cunha RA, de Mendonça A, Ribeiro JA. Modification of adenosine modulation of synaptic transmission in the hippocampus of aged rats. British Journal of Pharmacology. 131: 1629-34. PMID 11139440 DOI: 10.1038/Sj.Bjp.0703736  0.464
2000 Pereira MF, Hernández MD, Pintor J, Miras-Portugal MT, Cunha RA, Ribeiro JA. Diadenosine polyphosphates facilitate the evoked release of acetylcholine from rat hippocampal nerve terminals. Brain Research. 879: 50-4. PMID 11011005 DOI: 10.1016/S0006-8993(00)02726-8  0.465
2000 Salgado AI, Cunha RA, Ribeiro JA. Facilitation by P(2) receptor activation of acetylcholine release from rat motor nerve terminals: interaction with presynaptic nicotinic receptors. Brain Research. 877: 245-50. PMID 10986338 DOI: 10.1016/S0006-8993(00)02679-2  0.421
2000 Cunha RA, Almeida T, Ribeiro JA. Modification by arachidonic acid of extracellular adenosine metabolism and neuromodulatory action in the rat hippocampus. The Journal of Biological Chemistry. 275: 37572-81. PMID 10978314 DOI: 10.1074/jbc.M003011200  0.443
2000 Cunha RA, Ribeiro JA. Adenosine A2A receptor facilitation of synaptic transmission in the CA1 area of the rat hippocampus requires protein kinase C but not protein kinase A activation. Neuroscience Letters. 289: 127-30. PMID 10904136 DOI: 10.1016/S0304-3940(00)01295-7  0.457
2000 Rego AC, Agostinho P, Melo J, Cunha RA, Oliveira CR. Adenosine A2A receptors regulate the extracellular accumulation of excitatory amino acids upon metabolic dysfunction in chick cultured retinal cells. Experimental Eye Research. 70: 577-87. PMID 10870516 DOI: 10.1006/exer.1999.0815  0.45
2000 Pereira MF, Cunha RA, Ribeiro JA. Tonic adenosine neuromodulation is preserved in motor nerve endings of aged rats. Neurochemistry International. 36: 563-6. PMID 10771114 DOI: 10.1016/S0197-0186(99)00164-3  0.441
2000 Cunha RA, Ribeiro JA. Purinergic modulation of [(3)H]GABA release from rat hippocampal nerve terminals. Neuropharmacology. 39: 1156-67. PMID 10760359 DOI: 10.1016/S0028-3908(99)00237-3  0.446
2000 Cunha RA, Malva JO, Ribeiro JA. Pertussis toxin prevents presynaptic inhibition by kainate receptors of rat hippocampal [(3)H]GABA release. Febs Letters. 469: 159-62. PMID 10713263 DOI: 10.1016/S0014-5793(00)01272-2  0.402
2000 Agostinho P, Caseiro P, Rego AC, Duarte EP, Cunha RA, Oliveira CR. Adenosine modulation of D-[3H]aspartate release in cultured retina cells exposed to oxidative stress. Neurochemistry International. 36: 255-65. PMID 10676861 DOI: 10.1016/S0197-0186(99)00113-8  0.407
2000 Cunha RA, Brendel P, Zimmermann H, Ribeiro JA. Immunologically distinct isoforms of ecto-5'-nucleotidase in nerve terminals of different areas of the rat hippocampus. Journal of Neurochemistry. 74: 334-8. PMID 10617137 DOI: 10.1046/J.1471-4159.2000.0740334.X  0.324
1999 Lopes LV, Cunha RA, Ribeiro JA. Cross talk between A(1) and A(2A) adenosine receptors in the hippocampus and cortex of young adult and old rats. Journal of Neurophysiology. 82: 3196-203. PMID 10601453 DOI: 10.1152/Jn.1999.82.6.3196  0.493
1999 Lopes LV, Cunha RA, Ribeiro JA. ZM 241385, an adenosine A(2A) receptor antagonist, inhibits hippocampal A(1) receptor responses. European Journal of Pharmacology. 383: 395-8. PMID 10594334 DOI: 10.1016/S0014-2999(99)00659-7  0.474
1999 Sebastião AM, Cunha RA, Cascalheira JF, Ribeiro JA. Adenine nucleotides as inhibitors of synaptic transmission: role of localised ectonucleotidases. Progress in Brain Research. 120: 183-92. PMID 10550997 DOI: 10.1016/S0079-6123(08)63555-4  0.439
1999 Lopes LV, Cunha RA, Ribeiro JA. Increase in the number, G protein coupling, and efficiency of facilitatory adenosine A2A receptors in the limbic cortex, but not striatum, of aged rats. Journal of Neurochemistry. 73: 1733-8. PMID 10501222 DOI: 10.1046/J.1471-4159.1999.731733.X  0.417
1999 Cunha RA, Malva JO, Ribeiro JA. Kainate receptors coupled to G(i)/G(o) proteins in the rat hippocampus. Molecular Pharmacology. 56: 429-33. PMID 10419564 DOI: 10.1124/Mol.56.2.429  0.358
1999 Cunha RA, Constantino MD, Ribeiro JA. G protein coupling of CGS 21680 binding sites in the rat hippocampus and cortex is different from that of adenosine A1 and striatal A2A receptors. Naunyn-Schmiedeberg's Archives of Pharmacology. 359: 295-302. PMID 10344528 DOI: 10.1007/Pl00005355  0.356
1999 Cunha RA, Ribeiro JA. Facilitation of GABA release by arachidonic acid in rat hippocampal synaptosomes. The European Journal of Neuroscience. 11: 2171-4. PMID 10336686 DOI: 10.1046/J.1460-9568.1999.00661.X  0.375
1999 Almeida T, Cunha RA, Ribeiro JA. Facilitation by arachidonic acid of acetylcholine release from the rat hippocampus. Brain Research. 826: 104-11. PMID 10216201 DOI: 10.1016/S0006-8993(99)01267-6  0.369
1998 Cunha RA. On slices, synaptosomes and dissociated neurones to study in vitro ageing physiology. Trends in Neurosciences. 21: 286; author reply 28. PMID 9683318 DOI: 10.1016/S0166-2236(98)01243-0  0.3
1998 Cunha RA, Sebastião AM, Ribeiro JA. Inhibition by ATP of hippocampal synaptic transmission requires localized extracellular catabolism by ecto-nucleotidases into adenosine and channeling to adenosine A1 receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 1987-95. PMID 9482785 DOI: 10.1523/Jneurosci.18-06-01987.1998  0.433
1997 Gonçalves ML, Cunha RA, Ribeiro JA. Adenosine A2A receptors facilitate 45Ca2+ uptake through class A calcium channels in rat hippocampal CA3 but not CA1 synaptosomes. Neuroscience Letters. 238: 73-7. PMID 9464658 DOI: 10.1016/S0304-3940(97)00803-3  0.336
1997 Cunha RA, Constantino MD, Ribeiro JA. ZM241385 is an antagonist of the facilitatory responses produced by the A2A adenosine receptor agonists CGS21680 and HENECA in the rat hippocampus. British Journal of Pharmacology. 122: 1279-84. PMID 9421273 DOI: 10.1038/sj.bjp.0701507  0.403
1997 Cunha RA, Constantino MD, Ribeiro JA. Inhibition of [3H] gamma-aminobutyric acid release by kainate receptor activation in rat hippocampal synaptosomes. European Journal of Pharmacology. 323: 167-72. PMID 9128835 DOI: 10.1016/S0014-2999(97)00043-5  0.406
1996 Ribeiro JA, Cunha RA, Correia-de-Sá P, Sebastião AM. Purinergic regulation of acetylcholine release. Progress in Brain Research. 109: 231-41. PMID 9009712 DOI: 10.1016/S0079-6123(08)62107-X  0.474
1996 Cunha RA, Correia-de-Sá P, Sebastião AM, Ribeiro JA. Preferential activation of excitatory adenosine receptors at rat hippocampal and neuromuscular synapses by adenosine formed from released adenine nucleotides. British Journal of Pharmacology. 119: 253-60. PMID 8886406 DOI: 10.1111/J.1476-5381.1996.Tb15979.X  0.469
1996 Cunha RA, Vizi ES, Ribeiro JA, Sebastião AM. Preferential release of ATP and its extracellular catabolism as a source of adenosine upon high- but not low-frequency stimulation of rat hippocampal slices. Journal of Neurochemistry. 67: 2180-7. PMID 8863529 DOI: 10.1046/J.1471-4159.1996.67052180.X  0.329
1996 Cunha RA, Johansson B, Constantino MD, Sebastião AM, Fredholm BB. Evidence for high-affinity binding sites for the adenosine A2A receptor agonist [3H] CGS 21680 in the rat hippocampus and cerebral cortex that are different from striatal A2A receptors. Naunyn-Schmiedeberg's Archives of Pharmacology. 353: 261-71. PMID 8692280 DOI: 10.1007/Bf00168627  0.502
1996 Ribeiro JA, Mendona Ad, Correia-de-S P, Cunha RA, Sebastio AM. Purinoceptors and synaptic plasticity Drug Development Research. 39: 353-360. DOI: 10.1002/(Sici)1098-2299(199611/12)39:3/4<353::Aid-Ddr16>3.0.Co;2-2  0.484
1995 Cunha RA, Constantino MC, Sebastião AM, Ribeiro JA. Modification of A1 and A2a adenosine receptor binding in aged striatum, hippocampus and cortex of the rat. Neuroreport. 6: 1583-8. PMID 7579154  0.304
1995 Malva JO, Ambrósio AF, Cunha RA, Ribeiro JA, Carvalho AP, Carvalho CM. A functionally active presynaptic high-affinity kainate receptor in the rat hippocampal CA3 subregion. Neuroscience Letters. 185: 83-6. PMID 7538212 DOI: 10.1016/0304-3940(94)11230-G  0.355
1995 Cunha RA, Johansson B, Fredholm BB, Ribeiro JA, Sebastião AM. Adenosine A2A receptors stimulate acetylcholine release from nerve terminals of the rat hippocampus. Neuroscience Letters. 196: 41-4. PMID 7501252 DOI: 10.1016/0304-3940(95)11833-I  0.609
1994 Cunha RA, Milusheva E, Vizi ES, Ribeiro JA, Sebastião AM. Excitatory and inhibitory effects of A1 and A2A adenosine receptor activation on the electrically evoked [3H]acetylcholine release from different areas of the rat hippocampus. Journal of Neurochemistry. 63: 207-14. PMID 8207430 DOI: 10.1046/J.1471-4159.1994.63010207.X  0.378
1994 Cunha RA, Ribeiro JA, Sebastião AM. Purinergic modulation of the evoked release of [3H]acetylcholine from the hippocampus and cerebral cortex of the rat: role of the ectonucleotidases. The European Journal of Neuroscience. 6: 33-42. PMID 8130931 DOI: 10.1111/J.1460-9568.1994.Tb00245.X  0.363
1994 Cunha RA, Johansson B, van der Ploeg I, Sebastião AM, Ribeiro JA, Fredholm BB. Evidence for functionally important adenosine A2a receptors in the rat hippocampus. Brain Research. 649: 208-16. PMID 7953635 DOI: 10.1016/0006-8993(94)91066-9  0.596
1994 Sebastião A, Cunha R, de Mendonça A, Ribeiro J. Inhibition and excitation by adenosine in the rat hippocampus Journal of Physiology-Paris. 88: 410. DOI: 10.1016/0928-4257(94)90076-0  0.333
1993 Cunha RA, Sebastião AM. Adenosine and adenine nucleotides are independently released from both the nerve terminals and the muscle fibres upon electrical stimulation of the innervated skeletal muscle of the frog. Pflã¼Gers Archiv : European Journal of Physiology. 424: 503-10. PMID 8255734 DOI: 10.1007/Bf00374914  0.306
1992 Cunha RA, Sebastião AM, Ribeiro JA. Ecto-5'-nucleotidase is associated with cholinergic nerve terminals in the hippocampus but not in the cerebral cortex of the rat. Journal of Neurochemistry. 59: 657-66. PMID 1629736 DOI: 10.1111/J.1471-4159.1992.Tb09420.X  0.336
1992 Cunha RA, Sebastião AM. ECTO-ATPase activity in cholinergic nerve terminals of the hippocampus and of the cerebral cortex of the rat Neurochemistry International. 21. DOI: 10.1016/0197-0186(92)91940-X  0.301
1991 Cunha RA, Sebastião AM. Extracellular metabolism of adenine nucleotides and adenosine in the innervated skeletal muscle of the frog. European Journal of Pharmacology. 197: 83-92. PMID 1654262 DOI: 10.1016/0014-2999(91)90368-Z  0.305
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