Bodo Laube - Publications

MPI for Brain Research, Frankfurt am Main, Hessen, Germany 

74 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Bernhard M, Laube B. Thermophoretic analysis of ligand-specific conformational states of the inhibitory glycine receptor embedded in copolymer nanodiscs. Scientific Reports. 10: 16569. PMID 33024136 DOI: 10.1038/s41598-020-73157-2  0.56
2019 Bernhard M, Diefenbach M, Biesalski M, Laube B. Electrical sensing of phosphonates by functional coupling of phosphonate binding protein PhnD to solid-state nanopores. Acs Sensors. PMID 31829017 DOI: 10.1021/acssensors.9b02097  0.56
2017 Bledsoe D, Tamer C, Mesic I, Madry C, Klein BG, Laube B, Costa BM. Positive Modulatory Interactions of NMDA Receptor GluN1/2B Ligand Binding Domains Attenuate Antagonists Activity. Frontiers in Pharmacology. 8: 229. PMID 28536523 DOI: 10.3389/fphar.2017.00229  0.8
2016 Lemke JR, Geider K, Helbig KL, Heyne HO, Schütz H, Hentschel J, Courage C, Depienne C, Nava C, Heron D, Møller RS, Hjalgrim H, Lal D, Neubauer BA, Nürnberg P, ... ... Laube B, et al. Delineating the GRIN1 phenotypic spectrum: A distinct genetic NMDA receptor encephalopathy. Neurology. PMID 27164704 DOI: 10.1212/WNL.0000000000002740  1
2016 Mesic I, Madry C, Geider K, Bernhard M, Betz H, Laube B. The N-terminal Domain of the GluN3A Subunit determines the Efficacy of Glycine-activated NMDA Receptors. Neuropharmacology. PMID 26777280 DOI: 10.1016/j.neuropharm.2016.01.014  1
2015 Lynagh T, Beech RN, Lalande MJ, Keller K, Cromer BA, Wolstenholme AJ, Laube B. Molecular basis for convergent evolution of glutamate recognition by pentameric ligand-gated ion channels. Scientific Reports. 5: 8558. PMID 25708000 DOI: 10.1038/srep08558  1
2014 Lynagh T, Cromer BA, Dufour V, Laube B. Comparative pharmacology of flatworm and roundworm glutamate-gated chloride channels: Implications for potential anthelmintics. International Journal For Parasitology. Drugs and Drug Resistance. 4: 244-55. PMID 25516835 DOI: 10.1016/j.ijpddr.2014.07.004  1
2014 Lynagh T, Laube B. Opposing effects of the anesthetic propofol at pentameric ligand-gated ion channels mediated by a common site. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 2155-9. PMID 24501356 DOI: 10.1523/JNEUROSCI.4307-13.2014  1
2014 Lemke JR, Hendrickx R, Geider K, Laube B, Schwake M, Harvey RJ, James VM, Pepler A, Steiner I, Hörtnagel K, Neidhardt J, Ruf S, Wolff M, Bartholdi D, Caraballo R, et al. GRIN2B mutations in West syndrome and intellectual disability with focal epilepsy. Annals of Neurology. 75: 147-54. PMID 24272827 DOI: 10.1002/ana.24073  1
2013 Lynagh T, Kunz A, Laube B. Propofol modulation of α1 glycine receptors does not require a structural transition at adjacent subunits that is crucial to agonist-induced activation. Acs Chemical Neuroscience. 4: 1469-78. PMID 23992940 DOI: 10.1021/cn400134p  1
2013 Lemke JR, Lal D, Reinthaler EM, Steiner I, Nothnagel M, Alber M, Geider K, Laube B, Schwake M, Finsterwalder K, Franke A, Schilhabel M, Jähn JA, Muhle H, Boor R, et al. Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes. Nature Genetics. 45: 1067-72. PMID 23933819 DOI: 10.1038/ng.2728  1
2012 Dutertre S, Drwal M, Laube B, Betz H. Probing the pharmacological properties of distinct subunit interfaces within heteromeric glycine receptors reveals a functional ββ agonist-binding site. Journal of Neurochemistry. 122: 38-47. PMID 22486198 DOI: 10.1111/j.1471-4159.2012.07755.x  1
2012 Costa BM, Irvine MW, Fang G, Eaves RJ, Mayo-Martin MB, Laube B, Jane DE, Monaghan DT. Structure-activity relationships for allosteric NMDA receptor inhibitors based on 2-naphthoic acid. Neuropharmacology. 62: 1730-6. PMID 22155206 DOI: 10.1016/j.neuropharm.2011.11.019  1
2012 Kallenborn-Gerhardt W, Lu R, Lorenz J, Gao W, Weiland J, Del Turco D, Deller T, Laube B, Betz H, Geisslinger G, Schmidtko A. Prolonged zymosan-induced inflammatory pain hypersensitivity in mice lacking glycine receptor alpha2. Behavioural Brain Research. 226: 106-11. PMID 21924294 DOI: 10.1016/j.bbr.2011.09.002  1
2011 Pult F, Fallah G, Braam U, Detro-Dassen S, Niculescu C, Laube B, Schmalzing G. Robust post-translocational N-glycosylation at the extreme C-terminus of membrane and secreted proteins in Xenopus laevis oocytes and HEK293 cells. Glycobiology. 21: 1147-60. PMID 21303814 DOI: 10.1093/glycob/cwr013  1
2010 Endele S, Rosenberger G, Geider K, Popp B, Tamer C, Stefanova I, Milh M, Kortüm F, Fritsch A, Pientka FK, Hellenbroich Y, Kalscheuer VM, Kohlhase J, Moog U, Rappold G, ... ... Laube B, et al. Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes. Nature Genetics. 42: 1021-6. PMID 20890276 DOI: 10.1038/ng.677  1
2010 Madry C, Betz H, Geiger JR, Laube B. Potentiation of Glycine-Gated NR1/NR3A NMDA Receptors Relieves Ca-Dependent Outward Rectification. Frontiers in Molecular Neuroscience. 3: 6. PMID 20407581 DOI: 10.3389/fnmol.2010.00006  1
2010 Haeger S, Kuzmin D, Detro-Dassen S, Lang N, Kilb M, Tsetlin V, Betz H, Laube B, Schmalzing G. An intramembrane aromatic network determines pentameric assembly of Cys-loop receptors. Nature Structural & Molecular Biology. 17: 90-8. PMID 20023641 DOI: 10.1038/nsmb.1721  1
2009 Maksay G, Laube B, Schemm R, Grudzinska J, Drwal M, Betz H. Different binding modes of tropeines mediating inhibition and potentiation of alpha1 glycine receptors. Journal of Neurochemistry. 109: 1725-32. PMID 19383091 DOI: 10.1111/j.1471-4159.2009.06083.x  1
2009 Schumann T, Grudzinska J, Kuzmin D, Betz H, Laube B. Binding-site mutations in the alpha1 subunit of the inhibitory glycine receptor convert the inhibitory metal ion Cu2+ into a positive modulator. Neuropharmacology. 56: 310-7. PMID 18793654 DOI: 10.1016/j.neuropharm.2008.08.024  1
2008 Madry C, Betz H, Geiger JR, Laube B. Supralinear potentiation of NR1/NR3A excitatory glycine receptors by Zn2+ and NR1 antagonist. Proceedings of the National Academy of Sciences of the United States of America. 105: 12563-8. PMID 18711142 DOI: 10.1073/pnas.0805624105  1
2008 Grudzinska J, Schumann T, Schemm R, Betz H, Laube B. Mutations within the agonist-binding site convert the homomeric alpha1 glycine receptor into a Zn2+-activated chloride channel. Channels (Austin, Tex.). 2: 13-8. PMID 18690053 DOI: 10.4161/chan.2.1.5931  1
2008 Schüler T, Mesic I, Madry C, Bartholomäus I, Laube B. Formation of NR1/NR2 and NR1/NR3 heterodimers constitutes the initial step in N-methyl-D-aspartate receptor assembly. The Journal of Biological Chemistry. 283: 37-46. PMID 17959602 DOI: 10.1074/jbc.M703539200  1
2008 Maksay G, Bíró T, Laube B, Nemes P. Hyperekplexia mutation R271L of alpha1 glycine receptors potentiates allosteric interactions of nortropeines, propofol and glycine with [3H]strychnine binding. Neurochemistry International. 52: 235-40. PMID 17655979 DOI: 10.1016/j.neuint.2007.06.009  0.8
2007 Madry C, Mesic I, Betz H, Laube B. The N-terminal domains of both NR1 and NR2 subunits determine allosteric Zn2+ inhibition and glycine affinity of N-methyl-D-aspartate receptors. Molecular Pharmacology. 72: 1535-44. PMID 17878266 DOI: 10.1124/mol.107.040071  1
2007 Papadopoulos T, Korte M, Eulenburg V, Kubota H, Retiounskaia M, Harvey RJ, Harvey K, O'Sullivan GA, Laube B, Hülsmann S, Geiger JR, Betz H. Impaired GABAergic transmission and altered hippocampal synaptic plasticity in collybistin-deficient mice. The Embo Journal. 26: 3888-99. PMID 17690689 DOI: 10.1038/sj.emboj.7601819  1
2007 Madry C, Mesic I, Bartholomäus I, Nicke A, Betz H, Laube B. Principal role of NR3 subunits in NR1/NR3 excitatory glycine receptor function. Biochemical and Biophysical Research Communications. 354: 102-8. PMID 17214961 DOI: 10.1016/j.bbrc.2006.12.153  1
2007 Maier W, Schemm R, Grewer C, Laube B. Disruption of interdomain interactions in the glutamate binding pocket affects differentially agonist affinity and efficacy of N-methyl-D-aspartate receptor activation. The Journal of Biological Chemistry. 282: 1863-72. PMID 17105731 DOI: 10.1074/jbc.M608156200  1
2006 Hirzel K, Müller U, Latal AT, Hülsmann S, Grudzinska J, Seeliger MW, Betz H, Laube B. Hyperekplexia phenotype of glycine receptor alpha1 subunit mutant mice identifies Zn(2+) as an essential endogenous modulator of glycinergic neurotransmission. Neuron. 52: 679-90. PMID 17114051 DOI: 10.1016/j.neuron.2006.09.035  1
2006 Betz H, Laube B. Glycine receptors: recent insights into their structural organization and functional diversity. Journal of Neurochemistry. 97: 1600-10. PMID 16805771 DOI: 10.1111/j.1471-4159.2006.03908.x  1
2005 Kondratskaya EL, Betz H, Krishtal OA, Laube B. The beta subunit increases the ginkgolide B sensitivity of inhibitory glycine receptors. Neuropharmacology. 49: 945-51. PMID 16125206 DOI: 10.1016/j.neuropharm.2005.07.001  1
2005 Chandra T, Maier W, König HG, Hirzel K, Kögel D, Schüler T, Chandra A, Demirhan I, Laube B. Molecular interactions of the type 1 human immunodeficiency virus transregulatory protein Tat with N-methyl-d-aspartate receptor subunits. Neuroscience. 134: 145-53. PMID 15964699 DOI: 10.1016/j.neuroscience.2005.02.049  1
2005 Grudzinska J, Schemm R, Haeger S, Nicke A, Schmalzing G, Betz H, Laube B. The beta subunit determines the ligand binding properties of synaptic glycine receptors. Neuron. 45: 727-39. PMID 15748848 DOI: 10.1016/j.neuron.2005.01.028  1
2005 Maier W, Corrie JE, Papageorgiou G, Laube B, Grewer C. Comparative analysis of inhibitory effects of caged ligands for the NMDA receptor. Journal of Neuroscience Methods. 142: 1-9. PMID 15652611 DOI: 10.1016/j.jneumeth.2004.07.006  1
2004 Laube B, Schemm R, Betz H. Molecular determinants of ligand discrimination in the glutamate-binding pocket of the NMDA receptor. Neuropharmacology. 47: 994-1007. PMID 15555634 DOI: 10.1016/j.neuropharm.2004.07.041  1
2004 O'Shea SM, Becker L, Weiher H, Betz H, Laube B. Propofol restores the function of "hyperekplexic" mutant glycine receptors in Xenopus oocytes and mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 2322-7. PMID 14999083 DOI: 10.1523/JNEUROSCI.4675-03.2004  1
2003 Gomeza J, Ohno K, Hülsmann S, Armsen W, Eulenburg V, Richter DW, Laube B, Betz H. Deletion of the mouse glycine transporter 2 results in a hyperekplexia phenotype and postnatal lethality. Neuron. 40: 797-806. PMID 14622583 DOI: 10.1016/S0896-6273(03)00673-1  1
2003 Ortinau S, Laube B, Zimmermann H. ATP inhibits NMDA receptors after heterologous expression and in cultured hippocampal neurons and attenuates NMDA-mediated neurotoxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 4996-5003. PMID 12832522  1
2003 Foucaud B, Laube B, Schemm R, Kreimeyer A, Goeldner M, Betz H. Structural model of the N-methyl-D-aspartate receptor glycine site probed by site-directed chemical coupling. The Journal of Biological Chemistry. 278: 24011-7. PMID 12697759 DOI: 10.1074/jbc.M300219200  1
2003 Sadtler S, Laube B, Lashub A, Nicke A, Betz H, Schmalzing G. A basic cluster determines topology of the cytoplasmic M3-M4 loop of the glycine receptor alpha1 subunit. The Journal of Biological Chemistry. 278: 16782-90. PMID 12611885 DOI: 10.1074/jbc.M213077200  1
2002 Perret P, Laube B, Schemm R, Betz H, Goeldner M, Foucaud B. Affinity labeling of cysteine-mutants evidences contact residues in modeled receptor binding sites. Journal of Receptor and Signal Transduction Research. 22: 345-56. PMID 12503626 DOI: 10.1081/RRS-120014606  1
2002 Laube B, Maksay G, Schemm R, Betz H. Modulation of glycine receptor function: a novel approach for therapeutic intervention at inhibitory synapses? Trends in Pharmacological Sciences. 23: 519-27. PMID 12413807 DOI: 10.1016/S0165-6147(02)02138-7  1
2002 Laube B. Potentiation of inhibitory glycinergic neurotransmission by Zn2+: a synergistic interplay between presynaptic P2X2 and postsynaptic glycine receptors. The European Journal of Neuroscience. 16: 1025-36. PMID 12383231 DOI: 10.1046/j.1460-9568.2002.02170.x  1
2002 Maksay G, Bíró T, Laube B. Hyperekplexia mutation of glycine receptors: decreased gating efficacy with altered binding thermodynamics. Biochemical Pharmacology. 64: 285-8. PMID 12123749 DOI: 10.1016/S0006-2952(02)01111-5  1
2001 Wittekindt B, Malany S, Schemm R, Otvos L, Maccecchini ML, Laube B, Betz H. Point mutations identify the glutamate binding pocket of the N-methyl-D-aspartate receptor as major site of conantokin-G inhibition. Neuropharmacology. 41: 753-61. PMID 11640930 DOI: 10.1016/S0028-3908(01)00112-5  1
2001 Büttner C, Sadtler S, Leyendecker A, Laube B, Griffon N, Betz H, Schmalzing G. Ubiquitination precedes internalization and proteolytic cleavage of plasma membrane-bound glycine receptors. The Journal of Biological Chemistry. 276: 42978-85. PMID 11560918 DOI: 10.1074/jbc.M102121200  1
2001 Maksay G, Laube B, Betz H. Subunit-specific modulation of glycine receptors by neurosteroids. Neuropharmacology. 41: 369-76. PMID 11522328 DOI: 10.1016/S0028-3908(01)00071-5  1
2000 Harvey RJ, Schmieden V, Von Holst A, Laube B, Rohrer H, Betz H. Glycine receptors containing the alpha4 subunit in the embryonic sympathetic nervous system, spinal cord and male genital ridge. The European Journal of Neuroscience. 12: 994-1001. PMID 10762330 DOI: 10.1046/j.1460-9568.2000.00993.x  1
2000 Wittekindt B, Betz H, Laube B. Subunit-dependent inhibition of recombinant rodent N-methyl-D-aspartate receptors by a HIV-1 glycoprotein 120 derived peptide. Neuroscience Letters. 280: 151-4. PMID 10686400 DOI: 10.1016/S0304-3940(00)00775-8  1
2000 Laube B, Kuhse J, Betz H. Kinetic and mutational analysis of Zn2+ modulation of recombinant human inhibitory glycine receptors. The Journal of Physiology. 522: 215-30. PMID 10639099  1
1999 Kreimeyer A, Laube B, Sturgess M, Goeldner M, Foucaud B. Evaluation and biological properties of reactive ligands for the mapping of the glycine site on the N-methyl-D-aspartate (NMDA) receptor. Journal of Medicinal Chemistry. 42: 4394-404. PMID 10543883 DOI: 10.1021/jm9910730  1
1999 Kneussel M, Brandstätter JH, Laube B, Stahl S, Müller U, Betz H. Loss of postsynaptic GABA(A) receptor clustering in gephyrin-deficient mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 9289-97. PMID 10531433  1
1999 Maksay G, Laube B, Betz H. Selective blocking effects of tropisetron and atropine on recombinant glycine receptors. Journal of Neurochemistry. 73: 802-6. PMID 10428078 DOI: 10.1046/j.1471-4159.1999.0730802.x  1
1999 Betz H, Kuhse J, Schmieden V, Laube B, Kirsch J, Harvey RJ. Structure and functions of inhibitory and excitatory glycine receptors. Annals of the New York Academy of Sciences. 868: 667-76. PMID 10414351 DOI: 10.1111/j.1749-6632.1999.tb11343.x  1
1999 Kreimeyer A, Laube B, Sturgess M, Goeldner M, Foucaud B. Reactive affinity probes for the mapping of the glycine-binding site of the NMDA receptor NR1 subunit. Journal of Receptor and Signal Transduction Research. 19: 547-57. PMID 10071784 DOI: 10.3109/10799899909036671  1
1999 Kins S, Kuhse J, Laube B, Betz H, Kirsch J. Incorporation of a gephyrin-binding motif targets NMDA receptors to gephyrin-rich domains in HEK 293 cells. The European Journal of Neuroscience. 11: 740-4. PMID 10051776  0.56
1999 Laube B, Betz H. Purification and heterologous expression of inhibitory glycine receptors. Methods in Enzymology. 294: 260-73. PMID 9916232 DOI: 10.1016/S0076-6879(99)94016-8  1
1998 Ivanovic A, Reiländer H, Laube B, Kuhse J. Expression and initial characterization of a soluble glycine binding domain of the N-methyl-D-aspartate receptor NR1 subunit. The Journal of Biological Chemistry. 273: 19933-7. PMID 9685327 DOI: 10.1074/jbc.273.32.19933  1
1998 Nikolic Z, Laube B, Weber RG, Lichter P, Kioschis P, Poustka A, Mülhardt C, Becker CM. The human glycine receptor subunit alpha3. Glra3 gene structure, chromosomal localization, and functional characterization of alternative transcripts. The Journal of Biological Chemistry. 273: 19708-14. PMID 9677400 DOI: 10.1074/jbc.273.31.19708  1
1998 Honer M, Benke D, Laube B, Kuhse J, Heckendorn R, Allgeier H, Angst C, Monyer H, Seeburg PH, Betz H, Mohler H. Differentiation of glycine antagonist sites of N-methyl-D-aspartate receptor subtypes. Preferential interaction of CGP 61594 with NR1/2B receptors. The Journal of Biological Chemistry. 273: 11158-63. PMID 9556603 DOI: 10.1074/jbc.273.18.11158  1
1998 Laube B, Kuhse J, Betz H. Evidence for a tetrameric structure of recombinant NMDA receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 2954-61. PMID 9526012  1
1997 Laube B, Hirai H, Sturgess M, Betz H, Kuhse J. Molecular determinants of agonist discrimination by NMDA receptor subunits: analysis of the glutamate binding site on the NR2B subunit. Neuron. 18: 493-503. PMID 9115742 DOI: 10.1016/S0896-6273(00)81249-0  1
1996 Garcia-Guzman M, Soto F, Laube B, Stühmer W. Molecular cloning and functional expression of a novel rat heart P2X purinoceptor. Febs Letters. 388: 123-7. PMID 8690069 DOI: 10.1016/0014-5793(96)00499-1  1
1996 Hirai H, Kirsch J, Laube B, Betz H, Kuhse J. The glycine binding site of the N-methyl-D-aspartate receptor subunit NR1: identification of novel determinants of co-agonist potentiation in the extracellular M3-M4 loop region. Proceedings of the National Academy of Sciences of the United States of America. 93: 6031-6. PMID 8650214 DOI: 10.1073/pnas.93.12.6031  1
1995 Laube B, Kuhse J, Rundström N, Kirsch J, Schmieden V, Betz H. Modulation by zinc ions of native rat and recombinant human inhibitory glycine receptors. The Journal of Physiology. 483: 613-9. PMID 7776247  1
1995 Laube B, Langosch D, Betz H, Schmieden V. Hyperekplexia mutations of the glycine receptor unmask the inhibitory subsite for beta-amino-acids. Neuroreport. 6: 897-900. PMID 7542038  1
1994 Kuryatov A, Laube B, Betz H, Kuhse J. Mutational analysis of the glycine-binding site of the NMDA receptor: structural similarity with bacterial amino acid-binding proteins. Neuron. 12: 1291-300. PMID 8011339 DOI: 10.1016/0896-6273(94)90445-6  1
1994 Langosch D, Laube B, Rundström N, Schmieden V, Bormann J, Betz H. Decreased agonist affinity and chloride conductance of mutant glycine receptors associated with human hereditary hyperekplexia. The Embo Journal. 13: 4223-8. PMID 7925268  1
1994 Betz H, Kuhse J, Fischer M, Schmieden V, Laube B, Kuryatov A, Langosch D, Meyer G, Bormann J, Rundström N. Structure, diversity and synaptic localization of inhibitory glycine receptors. Journal of Physiology, Paris. 88: 243-8. PMID 7874085 DOI: 10.1016/0928-4257(94)90087-6  1
1993 Ultsch A, Schuster CM, Laube B, Betz H, Schmitt B. Glutamate receptors of Drosophila melanogaster. Primary structure of a putative NMDA receptor protein expressed in the head of the adult fly. Febs Letters. 324: 171-7. PMID 8508917 DOI: 10.1016/0014-5793(93)81387-F  1
1993 Kuhse J, Laube B, Magalei D, Betz H. Assembly of the inhibitory glycine receptor: identification of amino acid sequence motifs governing subunit stoichiometry. Neuron. 11: 1049-56. PMID 8274276 DOI: 10.1016/0896-6273(93)90218-G  1
1993 Laube B, Kuryatov A, Kuhse J, Betz H. Glycine-glutamate interactions at the NMDA receptor: role of cysteine residues. Febs Letters. 335: 331-4. PMID 7903251 DOI: 10.1016/0014-5793(93)80412-N  1
1992 Müller M, Laube B, Burda H, Bruns V. Structure and function of the cochlea in the African mole rat (Cryptomys hottentotus): evidence for a low frequency acoustic fovea. Journal of Comparative Physiology. a, Sensory, Neural, and Behavioral Physiology. 171: 469-76. PMID 1469665 DOI: 10.1007/BF00194579  1
1992 Ultsch A, Schuster CM, Laube B, Schloss P, Schmitt B, Betz H. Glutamate receptors of Drosophila melanogaster: cloning of a kainate-selective subunit expressed in the central nervous system. Proceedings of the National Academy of Sciences of the United States of America. 89: 10484-8. PMID 1359540 DOI: 10.1073/pnas.89.21.10484  1
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