Linda R. Watkins - Publications

Affiliations: 
University of Colorado, Boulder, Boulder, CO, United States 

399 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Peng Y, Zhang X, Zhang T, Grace PM, Li H, Wang Y, Li H, Chen H, Watkins LR, Hutchinson MR, Yin H, Wang X. Lovastatin inhibits Toll-like receptor 4 signaling in microglia by targeting its co-receptor myeloid differentiation protein 2 and attenuates neuropathic pain. Brain, Behavior, and Immunity. PMID 31542403 DOI: 10.1016/j.bbi.2019.09.013  1
2019 Green-Fulgham SM, Ball JB, Kwilasz AJ, Fabisiak T, Maier SF, Watkins LR, Grace PM. Oxycodone, fentanyl, and morphine amplify established neuropathic pain in male rats. Pain. PMID 31299018 DOI: 10.1097/j.pain.0000000000001652  1
2019 Wang X, Northcutt AL, Cochran TA, Zhang X, Fabisiak TJ, Haas ME, Amat J, Li H, Rice KC, Maier S, Bachtell RK, Hutchinson MR, Watkins LR. Methamphetamine activates Toll-like receptor 4 to induce central immune signaling within the ventral tegmental area and contributes to extracellular dopamine increase in the nucleus accumbens shell. Acs Chemical Neuroscience. PMID 31282647 DOI: 10.1021/acschemneuro.9b00225  1
2019 Zhang X, Peng Y, Grace PM, Metcalf MD, Kwilasz AJ, Wang Y, Zhang T, Wu S, Selfridge BR, Portoghese PS, Rice KC, Watkins LR, Hutchinson MR, Wang X. Stereochemistry and innate immune recognition: (+)-norbinaltorphimine targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201900173RRR. PMID 31162938 DOI: 10.1096/fj.201900173RRR  1
2019 Frank MG, Annis JL, Watkins LR, Maier SF. Glucocorticoids mediate stress induction of the alarmin HMGB1 and reduction of the microglia checkpoint receptor CD200R1 in limbic brain structures. Brain, Behavior, and Immunity. PMID 31078691 DOI: 10.1016/j.bbi.2019.05.014  1
2019 Frank MG, Fonken LK, Watkins LR, Maier SF. Microglia: Neuroimmune-sensors of stress. Seminars in Cell & Developmental Biology. PMID 30638704 DOI: 10.1016/j.semcdb.2019.01.001  1
2018 Gaudet AD, Fonken LK, Ayala MT, Bateman EM, Schleicher WE, Smith EJ, D'Angelo HM, Maier SF, Watkins LR. Spinal Cord Injury in Rats Disrupts the Circadian System. Eneuro. 5. PMID 30627655 DOI: 10.1523/ENEURO.0328-18.2018  1
2018 Gaudet AD, Fonken LK, Ayala MT, D'Angelo HM, Smith EJ, Bateman EM, Schleicher WE, Maier SF, Watkins L. Spinal cord injury in rats dysregulates diurnal rhythms of fecal output and liver metabolic indicators. Journal of Neurotrauma. PMID 30501584 DOI: 10.1089/neu.2018.6101  1
2018 Kwilasz AJ, Green Fulgham SM, Ellis A, Patel HP, Duran-Malle JC, Favret J, Harvey LO, Rieger J, Maier SF, Watkins LR. A single peri-sciatic nerve administration of the adenosine 2A receptor agonist ATL313 produces long-lasting anti-allodynia and anti-inflammatory effects in male rats. Brain, Behavior, and Immunity. PMID 30453021 DOI: 10.1016/j.bbi.2018.11.011  1
2018 Daut RA, Hartsock MJ, Tomczik AC, Watkins LR, Spencer RL, Maier SF, Fonken LK. Circadian misalignment has differential effects on affective behavior following exposure to controllable or uncontrollable stress. Behavioural Brain Research. PMID 30312639 DOI: 10.1016/j.bbr.2018.10.013  1
2018 Fonken LK, Frank MG, D'Angelo HM, Heinze JD, Watkins LR, Lowry CA, Maier SF. Mycobacterium vaccae immunization protects aged rats from surgery-elicited neuroinflammation and cognitive dysfunction. Neurobiology of Aging. 71: 105-114. PMID 30118926 DOI: 10.1016/j.neurobiolaging.2018.07.012  1
2018 Frank MG, Fonken LK, Watkins LR, Maier SF, Lowry CA. Could Probiotics Be Used to Mitigate Neuroinflammation? Acs Chemical Neuroscience. PMID 30109920 DOI: 10.1021/acschemneuro.8b00386  1
2018 Frank MG, Fonken LK, Dolzani SD, Annis JL, Siebler PH, Schmidt D, Watkins LR, Maier SF, Lowry CA. Immunization with Mycobacterium vaccae induces an anti-inflammatory milieu in the CNS: Attenuation of stress-induced microglial priming, alarmins and anxiety-like behavior. Brain, Behavior, and Immunity. PMID 29807129 DOI: 10.1016/j.bbi.2018.05.020  1
2018 Anttila JE, Albert K, Wires ES, Mätlik K, Loram LC, Watkins LR, Rice KC, Wang Y, Harvey BK, Airavaara M. Post-stroke Intranasal (+)-Naloxone Delivery Reduces Microglial Activation and Improves Behavioral Recovery from Ischemic Injury. Eneuro. 5. PMID 29766045 DOI: 10.1523/ENEURO.0395-17.2018  0.92
2018 Grace PM, Strand KA, Galer EL, Maier SF, Watkins LR. MicroRNA-124 and microRNA-146a both attenuate persistent neuropathic pain induced by morphine in male rats. Brain Research. PMID 29723521 DOI: 10.1016/j.brainres.2018.04.038  1
2018 Zhang K, Baratta MV, Liu G, Frank MG, Leslie NR, Watkins LR, Maier SF, Hutchinson MR, Goldys EM. A novel platform for in vivo detection of cytokine release within discrete brain regions. Brain, Behavior, and Immunity. PMID 29678795 DOI: 10.1016/j.bbi.2018.04.011  1
2018 Grace PM, Galer EL, Strand KA, Corrigan K, Berkelhammer D, Maier SF, Watkins LR. Repeated Morphine Prolongs Postoperative Pain in Male Rats. Anesthesia and Analgesia. PMID 29596097 DOI: 10.1213/ANE.0000000000003345  1
2018 Grace PM, Wang X, Strand KA, Baratta MV, Zhang Y, Galer EL, Yin H, Maier SF, Watkins LR. DREADDed microglia in pain: Implications for spinal inflammatory signaling in male rats. Experimental Neurology. PMID 29530713 DOI: 10.1016/j.expneurol.2018.03.005  1
2018 Fonken LK, Frank MG, Gaudet AD, D'Angelo HM, Daut RA, Hampson EC, Ayala MT, Watkins LR, Maier SF. Neuroinflammatory priming to stress is differentially regulated in male and female rats. Brain, Behavior, and Immunity. PMID 29524458 DOI: 10.1016/j.bbi.2018.03.005  1
2018 Zhang X, Cui F, Chen H, Zhang T, Yang K, Wang Y, Jiang Z, Rice KC, Watkins LR, Hutchinson MR, Li Y, Peng Y, Wang X. Dissecting the Innate Immune Recognition of Opioid Inactive Isomer (+)-Naltrexone Derived Toll-like Receptor 4 (TLR4) Antagonists. Journal of Chemical Information and Modeling. PMID 29518316 DOI: 10.1021/acs.jcim.7b00717  1
2018 Kwilasz AJ, Ellis A, Wieseler J, Loram L, Favret J, McFadden A, Springer K, Falci S, Rieger J, Maier SF, Watkins LR. Sustained Reversal of Central Neuropathic Pain Induced by a Single Intrathecal Injection of Adenosine A2A Receptor Agonists. Brain, Behavior, and Immunity. PMID 29366930 DOI: 10.1016/j.bbi.2018.01.005  1
2018 Baratta MV, Leslie NR, Fallon IP, Dolzani SD, Chun LE, Tamalunas AM, Watkins LR, Maier SF. Behavioral and neural sequelae of stressor exposure are not modulated by controllability in females. The European Journal of Neuroscience. PMID 29359831 DOI: 10.1111/ejn.13833  1
2017 Frank MG, Fonken LK, Annis JL, Watkins LR, Maier SF. Stress disinhibits microglia via down-regulation of CD200R: a mechanism of neuroinflammatory priming. Brain, Behavior, and Immunity. PMID 29104062 DOI: 10.1016/j.bbi.2017.11.001  1
2017 Lacagnina MJ, Watkins LR, Grace PM. Toll-like receptors and their role in persistent pain. Pharmacology & Therapeutics. PMID 28987324 DOI: 10.1016/j.pharmthera.2017.10.006  1
2017 Grace PM, Strand KA, Galer EL, Rice KC, Maier SF, Watkins LR. Protraction of neuropathic pain by morphine is mediated by spinal damage associated molecular patterns (DAMPs) in male rats. Brain, Behavior, and Immunity. PMID 28860068 DOI: 10.1016/j.bbi.2017.08.018  1
2017 Brown KT, Levis SC, O'Neill CE, Northcutt AL, Fabisiak TJ, Watkins LR, Bachtell RK. Innate Immune Signaling in the Ventral Tegmental Area Contributes to Drug-Primed Reinstatement of Cocaine Seeking. Brain, Behavior, and Immunity. PMID 28813640 DOI: 10.1016/j.bbi.2017.08.012  0.52
2017 Gaudet AD, Fonken LK, Watkins LR, Nelson RJ, Popovich PG. MicroRNAs: Roles in Regulating Neuroinflammation. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 1073858417721150. PMID 28737113 DOI: 10.1177/1073858417721150  0.6
2017 Spencer SJ, D'Angelo H, Soch A, Watkins LR, Maier SF, Barrientos RM. High-fat diet and aging interact to produce neuroinflammation and impair hippocampal- and amygdalar-dependent memory. Neurobiology of Aging. 58: 88-101. PMID 28719855 DOI: 10.1016/j.neurobiolaging.2017.06.014  1
2017 Gaudet AD, Ayala MT, Schleicher WE, Smith EJ, Bateman EM, Maier SF, Watkins LR. Exploring acute-to-chronic neuropathic pain in rats after contusion spinal cord injury. Experimental Neurology. PMID 28552717 DOI: 10.1016/j.expneurol.2017.05.011  1
2017 Lacagnina MJ, Kopec AM, Cox SS, Hanamsagar R, Wells C, Slade S, Grace PM, Watkins LR, Levin ED, Bilbo SD. Opioid Self-Administration is Attenuated by Early-Life Experience and Gene Therapy for Anti-Inflammatory IL-10 in the Nucleus Accumbens of Male Rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 28436446 DOI: 10.1038/npp.2017.82  1
2017 Wieseler J, Ellis A, McFadden A, Stone K, Brown K, Cady S, Bastos LF, Sprunger D, Rezvani N, Johnson K, Rice KC, Maier SF, Watkins LR. Supradural inflammatory soup in awake and freely moving rats induces facial allodynia that is blocked by putative immune modulators. Brain Research. PMID 28322750 DOI: 10.1016/j.brainres.2017.03.011  1
2016 Lewis SS, Grace PM, Hutchinson MR, Maier SF, Watkins LR. Constriction of the buccal branch of the facial nerve produces unilateral craniofacial allodynia. Brain, Behavior, and Immunity. PMID 27993689 DOI: 10.1016/j.bbi.2016.12.004  1
2016 Frank MG, Weber MD, Watkins LR, Maier SF. Stress-induced neuroinflammatory priming: A liability factor in the etiology of psychiatric disorders. Neurobiology of Stress. 4: 62-70. PMID 27981190 DOI: 10.1016/j.ynstr.2015.12.004  1
2016 Barrientos RM, Kitt MM, D'Angelo HM, Watkins LR, Rudy JW, Maier SF. Stable, long-term, spatial memory in young and aged rats achieved with a one day Morris water maze training protocol. Learning & Memory (Cold Spring Harbor, N.Y.). 23: 699-702. PMID 27918274 DOI: 10.1101/lm.043489.116  1
2016 Grace PM, Gaudet AD, Staikopoulos V, Maier SF, Hutchinson MR, Salvemini D, Watkins LR. Nitroxidative Signaling Mechanisms in Pathological Pain. Trends in Neurosciences. PMID 27842920 DOI: 10.1016/j.tins.2016.10.003  1
2016 Dolzani SD, Baratta MV, Amat J, Agster KL, Saddoris MP, Watkins LR, Maier SF. Activation of a Habenulo-Raphe Circuit Is Critical for the Behavioral and Neurochemical Consequences of Uncontrollable Stress in the Male Rat. Eneuro. 3. PMID 27785462 DOI: 10.1523/ENEURO.0229-16.2016  1
2016 Das N, Dewan V, Grace PM, Gunn RJ, Tamura R, Tzarum N, Watkins LR, Wilson IA, Yin H. HMGB1 Activates Proinflammatory Signaling via TLR5 Leading to Allodynia. Cell Reports. 17: 1128-1140. PMID 27760316 DOI: 10.1016/j.celrep.2016.09.076  1
2016 Dodds KN, Beckett EA, Evans SF, Grace PM, Watkins LR, Hutchinson MR. Glial contributions to visceral pain: implications for disease etiology and the female predominance of persistent pain. Translational Psychiatry. 6: e888. PMID 27622932 DOI: 10.1038/tp.2016.168  1
2016 Sobesky JL, D'Angelo HM, Weber MD, Anderson ND, Frank MG, Watkins LR, Maier SF, Barrientos RM. Glucocorticoids Mediate Short-Term High-Fat Diet Induction of Neuroinflammatory Priming, the NLRP3 Inflammasome, and the Danger Signal HMGB1. Eneuro. 3. PMID 27595136 DOI: 10.1523/ENEURO.0113-16.2016  1
2016 Fonken LK, Kitt MM, Gaudet AD, Barrientos RM, Watkins LR, Maier SF. Diminished circadian rhythms in hippocampal microglia may contribute to age-related neuroinflammatory sensitization. Neurobiology of Aging. 47: 102-112. PMID 27568094 DOI: 10.1016/j.neurobiolaging.2016.07.019  1
2016 Ellis A, Grace PM, Wieseler J, Favret J, Springer K, Skarda B, Hutchinson MR, Falci S, Rice KC, Maier SF, Watkins LR. Morphine amplifies mechanical allodynia via TLR4 in a rat model of spinal cord injury. Brain, Behavior, and Immunity. PMID 27519154 DOI: 10.1016/j.bbi.2016.08.004  1
2016 Fonken LK, Frank MG, Kitt MM, D'Angelo HM, Norden DM, Weber MD, Barrientos RM, Godbout JP, Watkins LR, Maier SF. The Alarmin HMGB1 Mediates Age-Induced Neuroinflammatory Priming. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 7946-56. PMID 27466339 DOI: 10.1523/JNEUROSCI.1161-16.2016  1
2016 Grace PM, Fabisiak TJ, Green-Fulgham SM, Anderson ND, Strand KA, Kwilasz AJ, Galer EL, Walker FR, Greenwood BN, Maier SF, Fleshner M, Watkins LR. Prior voluntary wheel running attenuates neuropathic pain. Pain. PMID 27355182 DOI: 10.1097/j.pain.0000000000000607  1
2016 Grace PM, Strand KA, Galer EL, Urban DJ, Wang X, Baratta MV, Fabisiak TJ, Anderson ND, Cheng K, Greene LI, Berkelhammer D, Zhang Y, Ellis AL, Yin HH, Campeau S, ... ... Watkins LR, et al. Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation. Proceedings of the National Academy of Sciences of the United States of America. PMID 27247388 DOI: 10.1073/pnas.1602070113  1
2016 Grace PM, Loram LC, Christianson JP, Strand KA, Flyer-Adams JG, Penzkover KR, Forsayeth JR, Dam AV, Mahoney MJ, Maier SF, Chavez RA, Watkins LR. Behavioral assessment of neuropathic pain, fatigue, and anxiety in experimental autoimmune encephalomyelitis (EAE) and attenuation by interleukin-10 gene therapy. Brain, Behavior, and Immunity. PMID 27189037 DOI: 10.1016/j.bbi.2016.05.012  1
2016 Fonken LK, Weber MD, Daut RA, Kitt MM, Frank MG, Watkins LR, Maier SF. Stress-induced neuroinflammatory priming is time of day dependent. Psychoneuroendocrinology. 66: 82-90. PMID 26799851 DOI: 10.1016/j.psyneuen.2016.01.006  0.84
2016 Amat J, Dolzani SD, Tilden S, Christianson JP, Kubala KH, Bartholomay K, Sperr K, Ciancio N, Watkins LR, Maier SF. Previous Ketamine Produces an Enduring Blockade of Neurochemical and Behavioral Effects of Uncontrollable Stress. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 153-61. PMID 26740657 DOI: 10.1523/JNEUROSCI.3114-15.2016  0.84
2015 Jacobsen JH, Hutchinson MR, Mustafa S. Drug addiction: targeting dynamic neuroimmune receptor interactions as a potential therapeutic strategy. Current Opinion in Pharmacology. 26: 131-137. PMID 26657076 DOI: 10.1016/j.coph.2015.10.010  1
2015 Wang X, Zhang Y, Peng Y, Hutchinson MR, Rice KC, Yin H, Watkins LR. Pharmacological characterization of the opioid inactive isomers (+)-naltrexone and (+)-naloxone as Toll-like receptor 4 antagonists. British Journal of Pharmacology. PMID 26603732 DOI: 10.1111/bph.13394  1
2015 Frank MG, Weber MD, Fonken LK, Hershman SA, Watkins LR, Maier SF. The redox state of the alarmin HMGB1 is a pivotal factor in neuroinflammatory and microglial priming: a role for the NLRP3 inflammasome. Brain, Behavior, and Immunity. PMID 26482581 DOI: 10.1016/j.bbi.2015.10.009  0.84
2015 Frank MG, Adhikary S, Sobesky JL, Weber MD, Watkins LR, Maier SF. The danger-associated molecular pattern HMGB1 mediates the neuroinflammatory effects of methamphetamine. Brain, Behavior, and Immunity. PMID 26254235 DOI: 10.1016/j.bbi.2015.08.001  0.84
2015 Frank MG, Watkins LR, Maier SF. The permissive role of glucocorticoids in neuroinflammatory priming: mechanisms and insights. Current Opinion in Endocrinology, Diabetes, and Obesity. 22: 300-5. PMID 26087336 DOI: 10.1097/MED.0000000000000168  0.84
2015 Bachtell R, Hutchinson MR, Wang X, Rice KC, Maier SF, Watkins LR. Targeting the Toll of Drug Abuse: The Translational Potential of Toll-Like Receptor 4. Cns & Neurological Disorders Drug Targets. 14: 692-9. PMID 26022268  1
2015 Selfridge BR, Wang X, Zhang Y, Yin H, Grace PM, Watkins LR, Jacobson AE, Rice KC. Structure-Activity Relationships of (+)-Naltrexone-Inspired Toll-like Receptor 4 (TLR4) Antagonists. Journal of Medicinal Chemistry. 58: 5038-52. PMID 26010811 DOI: 10.1021/acs.jmedchem.5b00426  0.84
2015 Grace PM, Maier SF, Watkins LR. Opioid-induced central immune signaling: implications for opioid analgesia. Headache. 55: 475-89. PMID 25833219 DOI: 10.1111/head.12552  1
2015 Frank MG, Weber MD, Watkins LR, Maier SF. Stress sounds the alarmin: The role of the danger-associated molecular pattern HMGB1 in stress-induced neuroinflammatory priming. Brain, Behavior, and Immunity. 48: 1-7. PMID 25816800 DOI: 10.1016/j.bbi.2015.03.010  0.84
2015 Grace PM, Shimizu K, Strand KA, Rice KC, Deng G, Watkins LR, Herson PS. (+)-Naltrexone is neuroprotective and promotes alternative activation in the mouse hippocampus after cardiac arrest/cardiopulmonary resuscitation. Brain, Behavior, and Immunity. 48: 115-22. PMID 25774010 DOI: 10.1016/j.bbi.2015.03.005  0.84
2015 Barrientos RM, Kitt MM, Watkins LR, Maier SF. Neuroinflammation in the normal aging hippocampus. Neuroscience. PMID 25772789 DOI: 10.1016/j.neuroscience.2015.03.007  0.84
2015 Loram LC, Strand KA, Taylor FR, Sloane E, Van Dam AM, Rieger J, Maier SF, Watkins LR. Adenosine 2A receptor agonism: A single intrathecal administration attenuates motor paralysis in experimental autoimmune encephalopathy in rats. Brain, Behavior, and Immunity. 46: 50-4. PMID 25653191 DOI: 10.1016/j.bbi.2015.01.014  0.84
2015 Northcutt AL, Hutchinson MR, Wang X, Baratta MV, Hiranita T, Cochran TA, Pomrenze MB, Galer EL, Kopajtic TA, Li CM, Amat J, Larson G, Cooper DC, Huang Y, O'Neill CE, ... ... Watkins LR, et al. DAT isn't all that: cocaine reward and reinforcement require Toll-like receptor 4 signaling. Molecular Psychiatry. PMID 25644383 DOI: 10.1038/mp.2014.177  1
2015 Griggs RB, Donahue RR, Morgenweck J, Grace PM, Sutton A, Watkins LR, Taylor BK. Pioglitazone rapidly reduces neuropathic pain through astrocyte and nongenomic PPARγ mechanisms. Pain. 156: 469-82. PMID 25599238 DOI: 10.1097/01.j.pain.0000460333.79127.be  1
2015 Weber MD, Frank MG, Tracey KJ, Watkins LR, Maier SF. Stress induces the danger-associated molecular pattern HMGB-1 in the hippocampus of male Sprague Dawley rats: a priming stimulus of microglia and the NLRP3 inflammasome. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 316-24. PMID 25568124 DOI: 10.1523/JNEUROSCI.3561-14.2015  0.84
2015 Barrientos RM, Thompson VM, Kitt MM, Amat J, Hale MW, Frank MG, Crysdale NY, Stamper CE, Hennessey PA, Watkins LR, Spencer RL, Lowry CA, Maier SF. Greater glucocorticoid receptor activation in hippocampus of aged rats sensitizes microglia. Neurobiology of Aging. 36: 1483-95. PMID 25559333 DOI: 10.1016/j.neurobiolaging.2014.12.003  1
2015 Corrigan F, Wu Y, Tuke J, Coller JK, Rice KC, Diener KR, Hayball JD, Watkins LR, Somogyi AA, Hutchinson MR. Alcohol-induced sedation and synergistic interactions between alcohol and morphine: a key mechanistic role for Toll-like receptors and MyD88-dependent signaling. Brain, Behavior, and Immunity. 45: 245-52. PMID 25542736 DOI: 10.1016/j.bbi.2014.12.019  0.84
2015 Kwilasz AJ, Grace PM, Serbedzija P, Maier SF, Watkins LR. The therapeutic potential of interleukin-10 in neuroimmune diseases. Neuropharmacology. 96: 55-69. PMID 25446571 DOI: 10.1016/j.neuropharm.2014.10.020  1
2015 Fonken LK, Frank MG, Kitt MM, Barrientos RM, Watkins LR, Maier SF. Microglia inflammatory responses are controlled by an intrinsic circadian clock. Brain, Behavior, and Immunity. 45: 171-9. PMID 25433170 DOI: 10.1016/j.bbi.2014.11.009  0.84
2015 Lewis SS, Hutchinson MR, Frick MM, Zhang Y, Maier SF, Sammakia T, Rice KC, Watkins LR. Select steroid hormone glucuronide metabolites can cause toll-like receptor 4 activation and enhanced pain. Brain, Behavior, and Immunity. 44: 128-36. PMID 25218902 DOI: 10.1016/j.bbi.2014.09.004  0.84
2015 Barrientos RM, Thompson VM, Arnold TH, Frank MG, Watkins LR, Maier SF. The role of hepatic and splenic macrophages in E. coli-induced memory impairments in aged rats. Brain, Behavior, and Immunity. 43: 60-7. PMID 25043992 DOI: 10.1016/j.bbi.2014.07.004  1
2015 Frank MG, Weber MD, Watkins LR, Maier SF. Stress-induced neuroinflammatory priming: A liability factor in the etiology of psychiatric disorders Neurobiology of Stress. DOI: 10.1016/j.ynstr.2015.12.004  1
2015 Bachtell R, Hutchinson MR, Wang X, Rice KC, Maier SF, Watkins LR. Targeting the toll of drug abuse: The translational potential of toll-like receptor 4 Cns and Neurological Disorders - Drug Targets. 14: 692-698.  0.84
2014 Christianson JP, Flyer-Adams JG, Drugan RC, Amat J, Daut RA, Foilb AR, Watkins LR, Maier SF. Learned stressor resistance requires extracellular signal-regulated kinase in the prefrontal cortex. Frontiers in Behavioral Neuroscience. 8: 348. PMID 25324750 DOI: 10.3389/fnbeh.2014.00348  1
2014 Grace PM, Ramos KM, Rodgers KM, Wang X, Hutchinson MR, Lewis MT, Morgan KN, Kroll JL, Taylor FR, Strand KA, Zhang Y, Berkelhammer D, Huey MG, Greene LI, Cochran TA, ... ... Watkins LR, et al. Activation of adult rat CNS endothelial cells by opioid-induced toll-like receptor 4 (TLR4) signaling induces proinflammatory, biochemical, morphological, and behavioral sequelae. Neuroscience. 280: 299-317. PMID 25241065 DOI: 10.1016/j.neuroscience.2014.09.020  1
2014 Jacobsen JH, Watkins LR, Hutchinson MR. Discovery of a novel site of opioid action at the innate immune pattern-recognition receptor TLR4 and its role in addiction. International Review of Neurobiology. 118: 129-63. PMID 25175864 DOI: 10.1016/B978-0-12-801284-0.00006-3  1
2014 Watkins LR, Wang X, Mustafa S, Hutchinson MR. In vivo veritas: (+)-Naltrexone's actions define translational importance: A letter in response to Skolnick et al. 'Translational potential of naloxone and naltrexone as TLR4 antagonists'. Trends in Pharmacological Sciences. 35: 432-3. PMID 25109571 DOI: 10.1016/j.tips.2014.07.002  0.84
2014 Zwicker JD, Zhang Y, Ren J, Hutchinson MR, Rice KC, Watkins LR, Greer JJ, Funk GD. Glial TLR4 signaling does not contribute to opioid-induced depression of respiration. Journal of Applied Physiology (Bethesda, Md. : 1985). 117: 857-68. PMID 25103966 DOI: 10.1152/japplphysiol.00534.2014  1
2014 Sobesky JL, Barrientos RM, De May HS, Thompson BM, Weber MD, Watkins LR, Maier SF. High-fat diet consumption disrupts memory and primes elevations in hippocampal IL-1β, an effect that can be prevented with dietary reversal or IL-1 receptor antagonism. Brain, Behavior, and Immunity. 42: 22-32. PMID 24998196 DOI: 10.1016/j.bbi.2014.06.017  1
2014 Amat J, Christianson JP, Aleksejev RM, Kim J, Richeson KR, Watkins LR, Maier SF. Control over a stressor involves the posterior dorsal striatum and the act/outcome circuit. The European Journal of Neuroscience. 40: 2352-8. PMID 24862585 DOI: 10.1111/ejn.12609  1
2014 Watkins LR, Hutchinson MR. A concern on comparing 'apples' and 'oranges' when differences between microglia used in human and rodent studies go far, far beyond simply species: comment on Smith and Dragunow. Trends in Neurosciences. 37: 189-90. PMID 24612510 DOI: 10.1016/j.tins.2014.02.004  1
2014 Grace PM, Hutchinson MR, Maier SF, Watkins LR. Pathological pain and the neuroimmune interface. Nature Reviews. Immunology. 14: 217-31. PMID 24577438 DOI: 10.1038/nri3621  1
2014 Frank MG, Hershman SA, Weber MD, Watkins LR, Maier SF. Chronic exposure to exogenous glucocorticoids primes microglia to pro-inflammatory stimuli and induces NLRP3 mRNA in the hippocampus. Psychoneuroendocrinology. 40: 191-200. PMID 24485491 DOI: 10.1016/j.psyneuen.2013.11.006  1
2014 Ellis A, Wieseler J, Favret J, Johnson KW, Rice KC, Maier SF, Falci S, Watkins LR. Systemic administration of propentofylline, ibudilast, and (+)-naltrexone each reverses mechanical allodynia in a novel rat model of central neuropathic pain. The Journal of Pain : Official Journal of the American Pain Society. 15: 407-21. PMID 24412802 DOI: 10.1016/j.jpain.2013.12.007  1
2014 Grace PM, Strand KA, Maier SF, Watkins LR. Suppression of voluntary wheel running in rats is dependent on the site of inflammation: evidence for voluntary running as a measure of hind paw-evoked pain. The Journal of Pain : Official Journal of the American Pain Society. 15: 121-8. PMID 24287315 DOI: 10.1016/j.jpain.2013.10.001  1
2014 Rodgers KM, Deming YK, Bercum FM, Chumachenko SY, Wieseler JL, Johnson KW, Watkins LR, Barth DS. Reversal of established traumatic brain injury-induced, anxiety-like behavior in rats after delayed, post-injury neuroimmune suppression. Journal of Neurotrauma. 31: 487-97. PMID 24041015 DOI: 10.1089/neu.2013.3090  1
2014 Hutchinson MR, Watkins LR. Why is neuroimmunopharmacology crucial for the future of addiction research? Neuropharmacology. 76: 218-27. PMID 23764149 DOI: 10.1016/j.neuropharm.2013.05.039  1
2013 Loram LC, Taylor FR, Strand KA, Harrison JA, Rzasalynn R, Sholar P, Rieger J, Maier SF, Watkins LR. Intrathecal injection of adenosine 2A receptor agonists reversed neuropathic allodynia through protein kinase (PK)A/PKC signaling. Brain, Behavior, and Immunity. 33: 112-22. PMID 23811314 DOI: 10.1016/j.bbi.2013.06.004  1
2013 Wang X, Grace PM, Pham MN, Cheng K, Strand KA, Smith C, Li J, Watkins LR, Yin H. Rifampin inhibits Toll-like receptor 4 signaling by targeting myeloid differentiation protein 2 and attenuates neuropathic pain. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 2713-22. PMID 23568774 DOI: 10.1096/fj.12-222992  1
2013 Bastos LF, Godin AM, Zhang Y, Jarussophon S, Ferreira BC, Machado RR, Maier SF, Konishi Y, de Freitas RP, Fiebich BL, Watkins LR, Coelho MM, Moraes MF. A minocycline derivative reduces nerve injury-induced allodynia, LPS-induced prostaglandin E2 microglial production and signaling via toll-like receptors 2 and 4. Neuroscience Letters. 543: 157-62. PMID 23523650 DOI: 10.1016/j.neulet.2013.03.014  1
2013 Weber MD, Frank MG, Sobesky JL, Watkins LR, Maier SF. Blocking toll-like receptor 2 and 4 signaling during a stressor prevents stress-induced priming of neuroinflammatory responses to a subsequent immune challenge. Brain, Behavior, and Immunity. 32: 112-21. PMID 23500798 DOI: 10.1016/j.bbi.2013.03.004  1
2013 Frank MG, Watkins LR, Maier SF. Stress-induced glucocorticoids as a neuroendocrine alarm signal of danger. Brain, Behavior, and Immunity. 33: 1-6. PMID 23459026 DOI: 10.1016/j.bbi.2013.02.004  1
2013 Theberge FR, Li X, Kambhampati S, Pickens CL, St Laurent R, Bossert JM, Baumann MH, Hutchinson MR, Rice KC, Watkins LR, Shaham Y. Effect of chronic delivery of the Toll-like receptor 4 antagonist (+)-naltrexone on incubation of heroin craving. Biological Psychiatry. 73: 729-37. PMID 23384483 DOI: 10.1016/j.biopsych.2012.12.019  1
2013 Christianson JP, Drugan RC, Flyer JG, Watkins LR, Maier SF. Anxiogenic effects of brief swim stress are sensitive to stress history. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 44: 17-22. PMID 23357538 DOI: 10.1016/j.pnpbp.2013.01.011  1
2013 Lewis SS, Hutchinson MR, Zhang Y, Hund DK, Maier SF, Rice KC, Watkins LR. Glucuronic acid and the ethanol metabolite ethyl-glucuronide cause toll-like receptor 4 activation and enhanced pain. Brain, Behavior, and Immunity. 30: 24-32. PMID 23348028 DOI: 10.1016/j.bbi.2013.01.005  1
2012 Loram LC, Taylor FR, Strand KA, Maier SF, Speake JD, Jordan KG, James JW, Wene SP, Pritchard RC, Green H, Van Dyke K, Mazarov A, Letchworth SR, Watkins LR. Systemic administration of an alpha-7 nicotinic acetylcholine agonist reverses neuropathic pain in male Sprague Dawley rats. The Journal of Pain : Official Journal of the American Pain Society. 13: 1162-71. PMID 23182225 DOI: 10.1016/j.jpain.2012.08.009  1
2012 Wang X, Fiorini Z, Smith C, Zhang Y, Li J, Watkins LR, Yin H. Repositioning antimicrobial agent pentamidine as a disruptor of the lateral interactions of transmembrane domain 5 of EBV latent membrane protein 1. Plos One. 7: e47703. PMID 23094078 DOI: 10.1371/journal.pone.0047703  1
2012 Barrientos RM, Hein AM, Frank MG, Watkins LR, Maier SF. Intracisternal interleukin-1 receptor antagonist prevents postoperative cognitive decline and neuroinflammatory response in aged rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 14641-8. PMID 23077050 DOI: 10.1523/JNEUROSCI.2173-12.2012  1
2012 Loram LC, Grace PM, Strand KA, Taylor FR, Ellis A, Berkelhammer D, Bowlin M, Skarda B, Maier SF, Watkins LR. Prior exposure to repeated morphine potentiates mechanical allodynia induced by peripheral inflammation and neuropathy. Brain, Behavior, and Immunity. 26: 1256-64. PMID 22902523 DOI: 10.1016/j.bbi.2012.08.003  1
2012 Hutchinson MR, Northcutt AL, Hiranita T, Wang X, Lewis SS, Thomas J, van Steeg K, Kopajtic TA, Loram LC, Sfregola C, Galer E, Miles NE, Bland ST, Amat J, Rozeske RR, ... ... Watkins LR, et al. Opioid activation of toll-like receptor 4 contributes to drug reinforcement. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 11187-200. PMID 22895704 DOI: 10.1523/JNEUROSCI.0684-12.2012  1
2012 Frank MG, Barrientos RM, Thompson BM, Weber MD, Watkins LR, Maier SF. IL-1RA injected intra-cisterna magna confers extended prophylaxis against lipopolysaccharide-induced neuroinflammatory and sickness responses. Journal of Neuroimmunology. 252: 33-9. PMID 22871632 DOI: 10.1016/j.jneuroim.2012.07.010  1
2012 Kubala KH, Christianson JP, Kaufman RD, Watkins LR, Maier SF. Short- and long-term consequences of stressor controllability in adolescent rats. Behavioural Brain Research. 234: 278-84. PMID 22771417 DOI: 10.1016/j.bbr.2012.06.027  1
2012 Grace PM, Hurley D, Barratt DT, Tsykin A, Watkins LR, Rolan PE, Hutchinson MR. Harnessing pain heterogeneity and RNA transcriptome to identify blood-based pain biomarkers: a novel correlational study design and bioinformatics approach in a graded chronic constriction injury model. Journal of Neurochemistry. 122: 976-94. PMID 22697386 DOI: 10.1111/j.1471-4159.2012.07833.x  1
2012 Helmreich DL, Tylee D, Christianson JP, Kubala KH, Govindarajan ST, O'Neill WE, Becoats K, Watkins L, Maier SF. Active behavioral coping alters the behavioral but not the endocrine response to stress. Psychoneuroendocrinology. 37: 1941-8. PMID 22578266 DOI: 10.1016/j.psyneuen.2012.04.005  1
2012 Hughes JP, Chessell I, Malamut R, Perkins M, Bačkonja M, Baron R, Farrar JT, Field MJ, Gereau RW, Gilron I, McMahon SB, Porreca F, Rappaport BA, Rice F, Richman LK, ... ... Watkins LR, et al. Understanding chronic inflammatory and neuropathic pain. Annals of the New York Academy of Sciences. 1255: 30-44. PMID 22564068 DOI: 10.1111/j.1749-6632.2012.06561.x  1
2012 Lewis SS, Loram LC, Hutchinson MR, Li CM, Zhang Y, Maier SF, Huang Y, Rice KC, Watkins LR. (+)-naloxone, an opioid-inactive toll-like receptor 4 signaling inhibitor, reverses multiple models of chronic neuropathic pain in rats. The Journal of Pain : Official Journal of the American Pain Society. 13: 498-506. PMID 22520687 DOI: 10.1016/j.jpain.2012.02.005  1
2012 Loram LC, Sholar PW, Taylor FR, Wiesler JL, Babb JA, Strand KA, Berkelhammer D, Day HE, Maier SF, Watkins LR. Sex and estradiol influence glial pro-inflammatory responses to lipopolysaccharide in rats. Psychoneuroendocrinology. 37: 1688-99. PMID 22497984 DOI: 10.1016/j.psyneuen.2012.02.018  1
2012 Wang X, Loram LC, Ramos K, de Jesus AJ, Thomas J, Cheng K, Reddy A, Somogyi AA, Hutchinson MR, Watkins LR, Yin H. Morphine activates neuroinflammation in a manner parallel to endotoxin. Proceedings of the National Academy of Sciences of the United States of America. 109: 6325-30. PMID 22474354 DOI: 10.1073/pnas.1200130109  1
2012 Rodgers KM, Bercum FM, McCallum DL, Rudy JW, Frey LC, Johnson KW, Watkins LR, Barth DS. Acute neuroimmune modulation attenuates the development of anxiety-like freezing behavior in an animal model of traumatic brain injury. Journal of Neurotrauma. 29: 1886-97. PMID 22435644 DOI: 10.1089/neu.2011.2273  1
2012 Barrientos RM, Frank MG, Watkins LR, Maier SF. Aging-related changes in neuroimmune-endocrine function: implications for hippocampal-dependent cognition. Hormones and Behavior. 62: 219-27. PMID 22370243 DOI: 10.1016/j.yhbeh.2012.02.010  1
2012 Wieseler J, Ellis A, Maier SF, Watkins LR, Falci S. Unilateral T13 and L1 dorsal root avulsion: methods for a novel model of central neuropathic pain. Methods in Molecular Biology (Clifton, N.J.). 851: 171-83. PMID 22351090 DOI: 10.1007/978-1-61779-561-9_12  1
2012 Wieseler J, Sprunger D, Ellis A, Maier SF, Watkins LR. Indwelling supradural catheters for induction of facial allodynia: surgical procedures, application of inflammatory stimuli, and behavioral testing. Methods in Molecular Biology (Clifton, N.J.). 851: 99-107. PMID 22351084 DOI: 10.1007/978-1-61779-561-9_6  1
2012 Bastos LF, de Oliveira AC, Watkins LR, Moraes MF, Coelho MM. Tetracyclines and pain. Naunyn-Schmiedeberg's Archives of Pharmacology. 385: 225-41. PMID 22282331 DOI: 10.1007/s00210-012-0727-1  1
2012 Watkins LR, Hutchinson MR, Johnson KW. Commentary on Landry et al.: "Propentofylline, a CNS glial modulator, does not decrease pain in post-herpetic neuralgia patients: in vitro evidence for differential responses in human and rodent microglia and macrophages". Experimental Neurology. 234: 351-3. PMID 22269389 DOI: 10.1016/j.expneurol.2012.01.006  1
2012 Bastos LF, Medeiros DC, Vieira RP, Watkins LR, Coelho MM, Moraes MF. Intraneural dexamethasone applied simultaneously to rat sciatic nerve constriction delays the development of hyperalgesia and allodynia. Neuroscience Letters. 510: 20-3. PMID 22240103 DOI: 10.1016/j.neulet.2011.12.062  1
2012 Rozeske RR, Der-Avakian A, Watkins LR, Maier SF. Activation of the medial prefrontal cortex by escapable stress is necessary for protection against subsequent inescapable stress-induced potentiation of morphine conditioned place preference. The European Journal of Neuroscience. 35: 160-5. PMID 22118376 DOI: 10.1111/j.1460-9568.2011.07929.x  1
2012 Frank MG, Thompson BM, Watkins LR, Maier SF. Glucocorticoids mediate stress-induced priming of microglial pro-inflammatory responses. Brain, Behavior, and Immunity. 26: 337-45. PMID 22041296 DOI: 10.1016/j.bbi.2011.10.005  1
2012 Nicotra L, Loram LC, Watkins LR, Hutchinson MR. Toll-like receptors in chronic pain. Experimental Neurology. 234: 316-29. PMID 22001158 DOI: 10.1016/j.expneurol.2011.09.038  1
2012 Wu Y, Lousberg EL, Moldenhauer LM, Hayball JD, Coller JK, Rice KC, Watkins LR, Somogyi AA, Hutchinson MR. Inhibiting the TLR4-MyD88 signalling cascade by genetic or pharmacological strategies reduces acute alcohol-induced sedation and motor impairment in mice. British Journal of Pharmacology. 165: 1319-29. PMID 21955045 DOI: 10.1111/j.1476-5381.2011.01572.x  1
2012 Johnston IN, Maier SF, Rudy JW, Watkins LR. Post-conditioning experience with acute or chronic inflammatory pain reduces contextual fear conditioning in the rat. Behavioural Brain Research. 226: 361-8. PMID 21920390 DOI: 10.1016/j.bbr.2011.08.048  1
2011 Rozeske RR, Evans AK, Frank MG, Watkins LR, Lowry CA, Maier SF. Uncontrollable, but not controllable, stress desensitizes 5-HT1A receptors in the dorsal raphe nucleus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 14107-15. PMID 21976495 DOI: 10.1523/JNEUROSCI.3095-11.2011  1
2011 Hains LE, Loram LC, Taylor FR, Strand KA, Wieseler JL, Barrientos RM, Young JJ, Frank MG, Sobesky J, Martin TJ, Eisenach JC, Maier SF, Johnson JD, Fleshner M, Watkins LR. Prior laparotomy or corticosterone potentiates lipopolysaccharide-induced fever and sickness behaviors. Journal of Neuroimmunology. 239: 53-60. PMID 21907418 DOI: 10.1016/j.jneuroim.2011.08.011  1
2011 Barrientos RM, Frank MG, Crysdale NY, Chapman TR, Ahrendsen JT, Day HE, Campeau S, Watkins LR, Patterson SL, Maier SF. Little exercise, big effects: reversing aging and infection-induced memory deficits, and underlying processes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 11578-86. PMID 21832188 DOI: 10.1523/JNEUROSCI.2266-11.2011  1
2011 Hutchinson MR, Shavit Y, Grace PM, Rice KC, Maier SF, Watkins LR. Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia. Pharmacological Reviews. 63: 772-810. PMID 21752874 DOI: 10.1124/pr.110.004135  1
2011 Christianson JP, Jennings JH, Ragole T, Flyer JG, Benison AM, Barth DS, Watkins LR, Maier SF. Safety signals mitigate the consequences of uncontrollable stress via a circuit involving the sensory insular cortex and bed nucleus of the stria terminalis. Biological Psychiatry. 70: 458-64. PMID 21684526 DOI: 10.1016/j.biopsych.2011.04.004  1
2011 Liu L, Ghosh N, Slivka PF, Fiorini Z, Hutchinson MR, Watkins LR, Yin H. An MD2 hot-spot-mimicking peptide that suppresses TLR4-mediated inflammatory response in vitro and in vivo. Chembiochem : a European Journal of Chemical Biology. 12: 1827-31. PMID 21678541 DOI: 10.1002/cbic.201100211  1
2011 Loram LC, Taylor FR, Strand KA, Frank MG, Sholar P, Harrison JA, Maier SF, Watkins LR. Prior exposure to glucocorticoids potentiates lipopolysaccharide induced mechanical allodynia and spinal neuroinflammation. Brain, Behavior, and Immunity. 25: 1408-15. PMID 21536123 DOI: 10.1016/j.bbi.2011.04.013  1
2011 Benison AM, Chumachenko S, Harrison JA, Maier SF, Falci SP, Watkins LR, Barth DS. Caudal granular insular cortex is sufficient and necessary for the long-term maintenance of allodynic behavior in the rat attributable to mononeuropathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 6317-28. PMID 21525272 DOI: 10.1523/JNEUROSCI.0076-11.2011  1
2011 Liu L, Coller JK, Watkins LR, Somogyi AA, Hutchinson MR. Naloxone-precipitated morphine withdrawal behavior and brain IL-1β expression: comparison of different mouse strains. Brain, Behavior, and Immunity. 25: 1223-32. PMID 21447380 DOI: 10.1016/j.bbi.2011.03.016  1
2011 Wu Y, Lousberg EL, Moldenhauer LM, Hayball JD, Robertson SA, Coller JK, Watkins LR, Somogyi AA, Hutchinson MR. Attenuation of microglial and IL-1 signaling protects mice from acute alcohol-induced sedation and/or motor impairment. Brain, Behavior, and Immunity. 25: S155-64. PMID 21276848 DOI: 10.1016/j.bbi.2011.01.012  1
2011 Rozeske RR, Greenwood BN, Fleshner M, Watkins LR, Maier SF. Voluntary wheel running produces resistance to inescapable stress-induced potentiation of morphine conditioned place preference. Behavioural Brain Research. 219: 378-81. PMID 21262267 DOI: 10.1016/j.bbr.2011.01.030  1
2011 Frank MG, Watkins LR, Maier SF. Stress- and glucocorticoid-induced priming of neuroinflammatory responses: potential mechanisms of stress-induced vulnerability to drugs of abuse. Brain, Behavior, and Immunity. 25: S21-8. PMID 21256955 DOI: 10.1016/j.bbi.2011.01.005  1
2010 Barrientos RM, Frank MG, Watkins LR, Maier SF. Memory impairments in healthy aging: Role of aging-induced microglial sensitization. Aging and Disease. 1: 212-231. PMID 21132050  1
2010 Muscoli C, Doyle T, Dagostino C, Bryant L, Chen Z, Watkins LR, Ryerse J, Bieberich E, Neumman W, Salvemini D. Counter-regulation of opioid analgesia by glial-derived bioactive sphingolipids. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 15400-8. PMID 21084596 DOI: 10.1523/JNEUROSCI.2391-10.2010  1
2010 Thompson BM, Baratta MV, Biedenkapp JC, Rudy JW, Watkins LR, Maier SF. Activation of the infralimbic cortex in a fear context enhances extinction learning. Learning & Memory (Cold Spring Harbor, N.Y.). 17: 591-9. PMID 21041382 DOI: 10.1101/lm.1920810  1
2010 Bevan DE, Martinko AJ, Loram LC, Stahl JA, Taylor FR, Joshee S, Watkins LR, Yin H. Selection, Preparation, and Evaluation of Small- Molecule Inhibitors of Toll-Like Receptor 4. Acs Medicinal Chemistry Letters. 1: 194-198. PMID 20824192 DOI: 10.1021/ml100041f  1
2010 Maier SF, Watkins LR. Role of the medial prefrontal cortex in coping and resilience. Brain Research. 1355: 52-60. PMID 20727864 DOI: 10.1016/j.brainres.2010.08.039  1
2010 Joce C, Stahl JA, Shridhar M, Hutchinson MR, Watkins LR, Fedichev PO, Yin H. Application of a novel in silico high-throughput screen to identify selective inhibitors for protein-protein interactions. Bioorganic & Medicinal Chemistry Letters. 20: 5411-3. PMID 20709548 DOI: 10.1016/j.bmcl.2010.07.103  1
2010 Wieseler J, Ellis AL, McFadden A, Brown K, Starnes C, Maier SF, Watkins LR, Falci S. Below level central pain induced by discrete dorsal spinal cord injury. Journal of Neurotrauma. 27: 1697-707. PMID 20649467 DOI: 10.1089/neu.2010.1311  1
2010 Ramos KM, Lewis MT, Morgan KN, Crysdale NY, Kroll JL, Taylor FR, Harrison JA, Sloane EM, Maier SF, Watkins LR. Spinal upregulation of glutamate transporter GLT-1 by ceftriaxone: therapeutic efficacy in a range of experimental nervous system disorders. Neuroscience. 169: 1888-900. PMID 20547213 DOI: 10.1016/j.neuroscience.2010.06.014  1
2010 Frank MG, Barrientos RM, Watkins LR, Maier SF. Aging sensitizes rapidly isolated hippocampal microglia to LPS ex vivo. Journal of Neuroimmunology. 226: 181-4. PMID 20537730 DOI: 10.1016/j.jneuroim.2010.05.022  1
2010 Hains LE, Loram LC, Weiseler JL, Frank MG, Bloss EB, Sholar P, Taylor FR, Harrison JA, Martin TJ, Eisenach JC, Maier SF, Watkins LR. Pain intensity and duration can be enhanced by prior challenge: initial evidence suggestive of a role of microglial priming. The Journal of Pain : Official Journal of the American Pain Society. 11: 1004-14. PMID 20434956 DOI: 10.1016/j.jpain.2010.01.271  1
2010 Buchanan MM, Hutchinson M, Watkins LR, Yin H. Toll-like receptor 4 in CNS pathologies. Journal of Neurochemistry. 114: 13-27. PMID 20402965 DOI: 10.1111/j.1471-4159.2010.06736.x  1
2010 Hutchinson MR, Loram LC, Zhang Y, Shridhar M, Rezvani N, Berkelhammer D, Phipps S, Foster PS, Landgraf K, Falke JJ, Rice KC, Maier SF, Yin H, Watkins LR. Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity. Neuroscience. 168: 551-63. PMID 20381591 DOI: 10.1016/j.neuroscience.2010.03.067  1
2010 Loram LC, Harrison JA, Chao L, Taylor FR, Reddy A, Travis CL, Giffard R, Al-Abed Y, Tracey K, Maier SF, Watkins LR. Intrathecal injection of an alpha seven nicotinic acetylcholine receptor agonist attenuates gp120-induced mechanical allodynia and spinal pro-inflammatory cytokine profiles in rats. Brain, Behavior, and Immunity. 24: 959-67. PMID 20353818 DOI: 10.1016/j.bbi.2010.03.008  1
2010 Soderquist RG, Sloane EM, Loram LC, Harrison JA, Dengler EC, Johnson SM, Amer LD, Young CS, Lewis MT, Poole S, Frank MG, Watkins LR, Milligan ED, Mahoney MJ. Release of plasmid DNA-encoding IL-10 from PLGA microparticles facilitates long-term reversal of neuropathic pain following a single intrathecal administration. Pharmaceutical Research. 27: 841-54. PMID 20224990 DOI: 10.1007/s11095-010-0077-y  1
2010 Bland ST, Beckley JT, Watkins LR, Maier SF, Bilbo SD. Neonatal Escherichia coli infection alters glial, cytokine, and neuronal gene expression in response to acute amphetamine in adolescent rats. Neuroscience Letters. 474: 52-7. PMID 20223277 DOI: 10.1016/j.neulet.2010.03.006  1
2010 Hutchinson MR, Lewis SS, Coats BD, Rezvani N, Zhang Y, Wieseler JL, Somogyi AA, Yin H, Maier SF, Rice KC, Watkins LR. Possible involvement of toll-like receptor 4/myeloid differentiation factor-2 activity of opioid inactive isomers causes spinal proinflammation and related behavioral consequences. Neuroscience. 167: 880-93. PMID 20178837 DOI: 10.1016/j.neuroscience.2010.02.011  1
2010 Christianson JP, Ragole T, Amat J, Greenwood BN, Strong PV, Paul ED, Fleshner M, Watkins LR, Maier SF. 5-hydroxytryptamine 2C receptors in the basolateral amygdala are involved in the expression of anxiety after uncontrollable traumatic stress. Biological Psychiatry. 67: 339-45. PMID 19914601 DOI: 10.1016/j.biopsych.2009.09.011  1
2010 Amat J, Aleksejev RM, Paul E, Watkins LR, Maier SF. Behavioral control over shock blocks behavioral and neurochemical effects of later social defeat. Neuroscience. 165: 1031-8. PMID 19909791 DOI: 10.1016/j.neuroscience.2009.11.005  1
2010 Wieseler J, Ellis A, Sprunger D, Brown K, McFadden A, Mahoney J, Rezvani N, Maier SF, Watkins LR. A novel method for modeling facial allodynia associated with migraine in awake and freely moving rats. Journal of Neuroscience Methods. 185: 236-45. PMID 19837113 DOI: 10.1016/j.jneumeth.2009.10.006  1
2010 Lewis SS, Hutchinson MR, Rezvani N, Loram LC, Zhang Y, Maier SF, Rice KC, Watkins LR. Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1beta. Neuroscience. 165: 569-83. PMID 19833175 DOI: 10.1016/j.neuroscience.2009.10.011  1
2010 Frank MG, Barrientos RM, Hein AM, Biedenkapp JC, Watkins LR, Maier SF. IL-1RA blocks E. coli-induced suppression of Arc and long-term memory in aged F344xBN F1 rats. Brain, Behavior, and Immunity. 24: 254-62. PMID 19822205 DOI: 10.1016/j.bbi.2009.10.005  1
2010 Bland ST, Beckley JT, Young S, Tsang V, Watkins LR, Maier SF, Bilbo SD. Enduring consequences of early-life infection on glial and neural cell genesis within cognitive regions of the brain. Brain, Behavior, and Immunity. 24: 329-38. PMID 19782746 DOI: 10.1016/j.bbi.2009.09.012  1
2010 Soderquist RG, Milligan ED, Harrison JA, Chavez RA, Johnson KW, Watkins LR, Mahoney MJ. PEGylation of interleukin-10 for the mitigation of enhanced pain states. Journal of Biomedical Materials Research. Part A. 93: 1169-79. PMID 19768789 DOI: 10.1002/jbm.a.32611  1
2010 Bilbo SD, Wieseler JL, Barrientos RM, Tsang V, Watkins LR, Maier SF. Neonatal bacterial infection alters fever to live and simulated infections in adulthood. Psychoneuroendocrinology. 35: 369-81. PMID 19682802 DOI: 10.1016/j.psyneuen.2009.07.014  1
2010 Hutchinson MR, Zhang Y, Shridhar M, Evans JH, Buchanan MM, Zhao TX, Slivka PF, Coats BD, Rezvani N, Wieseler J, Hughes TS, Landgraf KE, Chan S, Fong S, Phipps S, ... ... Watkins LR, et al. Evidence that opioids may have toll-like receptor 4 and MD-2 effects. Brain, Behavior, and Immunity. 24: 83-95. PMID 19679181 DOI: 10.1016/j.bbi.2009.08.004  1
2010 Frank MG, Miguel ZD, Watkins LR, Maier SF. Prior exposure to glucocorticoids sensitizes the neuroinflammatory and peripheral inflammatory responses to E. coli lipopolysaccharide. Brain, Behavior, and Immunity. 24: 19-30. PMID 19647070 DOI: 10.1016/j.bbi.2009.07.008  1
2010 Watkins LR, Milligan ED, Maier SF. Mechanisms of Glial Activation after Nerve Injury The Senses: a Comprehensive Reference. 5: 429-433. DOI: 10.1016/B978-012370880-9.00173-0  1
2009 Loram LC, Harrison JA, Sloane EM, Hutchinson MR, Sholar P, Taylor FR, Berkelhammer D, Coats BD, Poole S, Milligan ED, Maier SF, Rieger J, Watkins LR. Enduring reversal of neuropathic pain by a single intrathecal injection of adenosine 2A receptor agonists: a novel therapy for neuropathic pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 14015-25. PMID 19890011 DOI: 10.1523/JNEUROSCI.3447-09.2009  1
2009 Hutchinson MR, Ramos KM, Loram LC, Wieseler J, Sholar PW, Kearney JJ, Lewis MT, Crysdale NY, Zhang Y, Harrison JA, Maier SF, Rice KC, Watkins LR. Evidence for a role of heat shock protein-90 in toll like receptor 4 mediated pain enhancement in rats. Neuroscience. 164: 1821-32. PMID 19788917 DOI: 10.1016/j.neuroscience.2009.09.046  1
2009 Watkins LR, Hutchinson MR, Rice KC, Maier SF. The "toll" of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia. Trends in Pharmacological Sciences. 30: 581-91. PMID 19762094 DOI: 10.1016/j.tips.2009.08.002  1
2009 Baratta MV, Zarza CM, Gomez DM, Campeau S, Watkins LR, Maier SF. Selective activation of dorsal raphe nucleus-projecting neurons in the ventral medial prefrontal cortex by controllable stress. The European Journal of Neuroscience. 30: 1111-6. PMID 19686468 DOI: 10.1111/j.1460-9568.2009.06867.x  1
2009 Sloane E, Langer S, Jekich B, Mahoney J, Hughes T, Frank M, Seibert W, Huberty G, Coats B, Harrison J, Klinman D, Poole S, Maier S, Johnson K, Chavez R, ... Watkins LR, et al. Immunological priming potentiates non-viral anti-inflammatory gene therapy treatment of neuropathic pain. Gene Therapy. 16: 1210-22. PMID 19571887 DOI: 10.1038/gt.2009.79  1
2009 Rodgers KM, Hutchinson MR, Northcutt A, Maier SF, Watkins LR, Barth DS. The cortical innate immune response increases local neuronal excitability leading to seizures. Brain : a Journal of Neurology. 132: 2478-86. PMID 19567702 DOI: 10.1093/brain/awp177  1
2009 Bartley J, Watkins LR. Comment on: excessive opioid use and the development of chronic migraine. Pain. 145: 262-3. PMID 19553017 DOI: 10.1016/j.pain.2009.06.007  1
2009 Hughes TS, Langer SJ, Virtanen SI, Chavez RA, Watkins LR, Milligan ED, Leinwand LA. Immunogenicity of intrathecal plasmid gene delivery: cytokine release and effects on transgene expression. The Journal of Gene Medicine. 11: 782-90. PMID 19533588 DOI: 10.1002/jgm.1364  1
2009 Bland ST, Hutchinson MR, Maier SF, Watkins LR, Johnson KW. The glial activation inhibitor AV411 reduces morphine-induced nucleus accumbens dopamine release. Brain, Behavior, and Immunity. 23: 492-7. PMID 19486648 DOI: 10.1016/j.bbi.2009.01.014  1
2009 Barrientos RM, Watkins LR, Rudy JW, Maier SF. Characterization of the sickness response in young and aging rats following E. coli infection. Brain, Behavior, and Immunity. 23: 450-4. PMID 19486645 DOI: 10.1016/j.bbi.2009.01.016  1
2009 Sloane EM, Soderquist RG, Maier SF, Mahoney MJ, Watkins LR, Milligan ED. Long-term control of neuropathic pain in a non-viral gene therapy paradigm. Gene Therapy. 16: 470-5. PMID 19262611 DOI: 10.1038/gt.2009.21  1
2009 Slivka PF, Shridhar M, Lee GI, Sammond DW, Hutchinson MR, Martinko AJ, Buchanan MM, Sholar PW, Kearney JJ, Harrison JA, Watkins LR, Yin H. A peptide antagonist of the TLR4-MD2 interaction. Chembiochem : a European Journal of Chemical Biology. 10: 645-9. PMID 19184989 DOI: 10.1002/cbic.200800769  1
2009 Milligan ED, Watkins LR. Pathological and protective roles of glia in chronic pain. Nature Reviews. Neuroscience. 10: 23-36. PMID 19096368 DOI: 10.1038/nrn2533  1
2009 Christianson JP, Thompson BM, Watkins LR, Maier SF. Medial prefrontal cortical activation modulates the impact of controllable and uncontrollable stressor exposure on a social exploration test of anxiety in the rat. Stress (Amsterdam, Netherlands). 12: 445-50. PMID 19051125 DOI: 10.1080/10253890802510302  1
2009 Soderquist RG, Milligan ED, Sloane EM, Harrison JA, Douvas KK, Potter JM, Hughes TS, Chavez RA, Johnson K, Watkins LR, Mahoney MJ. PEGylation of brain-derived neurotrophic factor for preserved biological activity and enhanced spinal cord distribution. Journal of Biomedical Materials Research. Part A. 91: 719-29. PMID 19048635 DOI: 10.1002/jbm.a.32254  1
2009 Hughes TS, Langer SJ, Johnson KW, Chavez RA, Watkins LR, Milligan ED, Leinwand LA. Intrathecal injection of naked plasmid DNA provides long-term expression of secreted proteins. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 88-94. PMID 18941439 DOI: 10.1038/mt.2008.230  1
2009 Hutchinson MR, Lewis SS, Coats BD, Skyba DA, Crysdale NY, Berkelhammer DL, Brzeski A, Northcutt A, Vietz CM, Judd CM, Maier SF, Watkins LR, Johnson KW. Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast). Brain, Behavior, and Immunity. 23: 240-50. PMID 18938237 DOI: 10.1016/j.bbi.2008.09.012  1
2009 Sloane E, Ledeboer A, Seibert W, Coats B, van Strien M, Maier SF, Johnson KW, Chavez R, Watkins LR, Leinwand L, Milligan ED, Van Dam AM. Anti-inflammatory cytokine gene therapy decreases sensory and motor dysfunction in experimental Multiple Sclerosis: MOG-EAE behavioral and anatomical symptom treatment with cytokine gene therapy. Brain, Behavior, and Immunity. 23: 92-100. PMID 18835435 DOI: 10.1016/j.bbi.2008.09.004  1
2009 Barrientos RM, Frank MG, Hein AM, Higgins EA, Watkins LR, Rudy JW, Maier SF. Time course of hippocampal IL-1 beta and memory consolidation impairments in aging rats following peripheral infection. Brain, Behavior, and Immunity. 23: 46-54. PMID 18664380 DOI: 10.1016/j.bbi.2008.07.002  1
2009 Rozeske RR, Der-Avakian A, Bland ST, Beckley JT, Watkins LR, Maier SF. The medial prefrontal cortex regulates the differential expression of morphine-conditioned place preference following a single exposure to controllable or uncontrollable stress. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 834-43. PMID 18368036 DOI: 10.1038/npp.2008.34  1
2008 Christianson JP, Benison AM, Jennings J, Sandsmark EK, Amat J, Kaufman RD, Baratta MV, Paul ED, Campeau S, Watkins LR, Barth DS, Maier SF. The sensory insular cortex mediates the stress-buffering effects of safety signals but not behavioral control. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 13703-11. PMID 19074043 DOI: 10.1523/JNEUROSCI.4270-08.2008  1
2008 Hutchinson MR, Northcutt AL, Chao LW, Kearney JJ, Zhang Y, Berkelhammer DL, Loram LC, Rozeske RR, Bland ST, Maier SF, Gleeson TT, Watkins LR. Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia. Brain, Behavior, and Immunity. 22: 1248-56. PMID 18706994 DOI: 10.1016/j.bbi.2008.07.008  1
2008 Hutchinson MR, Zhang Y, Brown K, Coats BD, Shridhar M, Sholar PW, Patel SJ, Crysdale NY, Harrison JA, Maier SF, Rice KC, Watkins LR. Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4). The European Journal of Neuroscience. 28: 20-9. PMID 18662331 DOI: 10.1111/j.1460-9568.2008.06321.x  1
2008 Hutchinson MR, Coats BD, Lewis SS, Zhang Y, Sprunger DB, Rezvani N, Baker EM, Jekich BM, Wieseler JL, Somogyi AA, Martin D, Poole S, Judd CM, Maier SF, Watkins LR. Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia. Brain, Behavior, and Immunity. 22: 1178-89. PMID 18599265 DOI: 10.1016/j.bbi.2008.05.004  1
2008 Christianson JP, Paul ED, Irani M, Thompson BM, Kubala KH, Yirmiya R, Watkins LR, Maier SF. The role of prior stressor controllability and the dorsal raphé nucleus in sucrose preference and social exploration. Behavioural Brain Research. 193: 87-93. PMID 18554730 DOI: 10.1016/j.bbr.2008.04.024  1
2008 Milligan ED, Sloane EM, Watkins LR. Glia in pathological pain: a role for fractalkine. Journal of Neuroimmunology. 198: 113-20. PMID 18547654 DOI: 10.1016/j.jneuroim.2008.04.011  1
2008 Amat J, Paul E, Watkins LR, Maier SF. Activation of the ventral medial prefrontal cortex during an uncontrollable stressor reproduces both the immediate and long-term protective effects of behavioral control. Neuroscience. 154: 1178-86. PMID 18515010 DOI: 10.1016/j.neuroscience.2008.04.005  1
2008 Baratta MV, Lucero TR, Amat J, Watkins LR, Maier SF. Role of the ventral medial prefrontal cortex in mediating behavioral control-induced reduction of later conditioned fear. Learning & Memory (Cold Spring Harbor, N.Y.). 15: 84-7. PMID 18235108 DOI: 10.1101/lm.800308  1
2008 Bilbo SD, Yirmiya R, Amat J, Paul ED, Watkins LR, Maier SF. Bacterial infection early in life protects against stressor-induced depressive-like symptoms in adult rats. Psychoneuroendocrinology. 33: 261-9. PMID 18164556 DOI: 10.1016/j.psyneuen.2007.11.008  1
2008 Bilbo SD, Barrientos RM, Eads AS, Northcutt A, Watkins LR, Rudy JW, Maier SF. Early-life infection leads to altered BDNF and IL-1beta mRNA expression in rat hippocampus following learning in adulthood. Brain, Behavior, and Immunity. 22: 451-5. PMID 17997277 DOI: 10.1016/j.bbi.2007.10.003  1
2008 Spataro LE, Downs H, Wieseler J, Watkins LR, Oaklander AL, Horowitz SH. The persistent sciatic inflammatory neuropathy (sin) rat model of neuropathic pain does not involve small-fiber axon damage Journal of Neuropathic Pain and Symptom Palliation. 2: 41-47. DOI: 10.1300/J426v02n04_05  1
2007 Hein AM, Stutzman DL, Bland ST, Barrientos RM, Watkins LR, Rudy JW, Maier SF. Prostaglandins are necessary and sufficient to induce contextual fear learning impairments after interleukin-1 beta injections into the dorsal hippocampus. Neuroscience. 150: 754-63. PMID 18035502 DOI: 10.1016/j.neuroscience.2007.10.003  1
2007 Hutchinson MR, Bland ST, Johnson KW, Rice KC, Maier SF, Watkins LR. Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward. Thescientificworldjournal. 7: 98-111. PMID 17982582 DOI: 10.1100/tsw.2007.230  1
2007 Watkins LR, Hutchinson MR, Milligan ED, Maier SF. "Listening" and "talking" to neurons: implications of immune activation for pain control and increasing the efficacy of opioids. Brain Research Reviews. 56: 148-69. PMID 17706291 DOI: 10.1016/j.brainresrev.2007.06.006  1
2007 Ledeboer A, Hutchinson MR, Watkins LR, Johnson KW. Ibudilast (AV-411). A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes. Expert Opinion On Investigational Drugs. 16: 935-50. PMID 17594181 DOI: 10.1517/13543784.16.7.935  1
2007 Baratta MV, Christianson JP, Gomez DM, Zarza CM, Amat J, Masini CV, Watkins LR, Maier SF. Controllable versus uncontrollable stressors bi-directionally modulate conditioned but not innate fear. Neuroscience. 146: 1495-503. PMID 17478046 DOI: 10.1016/j.neuroscience.2007.03.042  1
2007 Kleibeuker W, Ledeboer A, Eijkelkamp N, Watkins LR, Maier SF, Zijlstra J, Heijnen CJ, Kavelaars A. A role for G protein-coupled receptor kinase 2 in mechanical allodynia. The European Journal of Neuroscience. 25: 1696-704. PMID 17408432 DOI: 10.1111/j.1460-9568.2007.05423.x  1
2007 Frank MG, Der-Avakian A, Bland ST, Watkins LR, Maier SF. Stress-induced glucocorticoids suppress the antisense molecular regulation of FGF-2 expression. Psychoneuroendocrinology. 32: 376-84. PMID 17383826 DOI: 10.1016/j.psyneuen.2007.02.001  1
2007 Holguin A, Frank MG, Biedenkapp JC, Nelson K, Lippert D, Watkins LR, Rudy JW, Maier SF. Characterization of the temporo-spatial effects of chronic bilateral intrahippocampal cannulae on interleukin-1beta. Journal of Neuroscience Methods. 161: 265-72. PMID 17241670 DOI: 10.1016/j.jneumeth.2006.11.014  1
2007 Der-Avakian A, Rozeske RR, Bland ST, Watkins LR, Maier SF. The effects of a single session of inescapable tailshock on the subsequent locomotor response to brief footshock and cocaine administration in rats. Psychopharmacology. 191: 899-907. PMID 17211648 DOI: 10.1007/s00213-006-0677-8  1
2007 Der-Avakian A, Bland ST, Rozeske RR, Tamblyn JP, Hutchinson MR, Watkins LR, Maier SF. The effects of a single exposure to uncontrollable stress on the subsequent conditioned place preference responses to oxycodone, cocaine, and ethanol in rats. Psychopharmacology. 191: 909-17. PMID 17211647 DOI: 10.1007/s00213-006-0678-7  1
2007 Schoeniger-Skinner DK, Ledeboer A, Frank MG, Milligan ED, Poole S, Martin D, Maier SF, Watkins LR. Interleukin-6 mediates low-threshold mechanical allodynia induced by intrathecal HIV-1 envelope glycoprotein gp120. Brain, Behavior, and Immunity. 21: 660-7. PMID 17204394 DOI: 10.1016/j.bbi.2006.10.010  1
2007 Bland ST, Tamlyn JP, Barrientos RM, Greenwood BN, Watkins LR, Campeau S, Day HE, Maier SF. Expression of fibroblast growth factor-2 and brain-derived neurotrophic factor mRNA in the medial prefrontal cortex and hippocampus after uncontrollable or controllable stress. Neuroscience. 144: 1219-28. PMID 17197100 DOI: 10.1016/j.neuroscience.2006.11.026  1
2007 Watkins LR, Hutchinson MR, Ledeboer A, Wieseler-Frank J, Milligan ED, Maier SF. Norman Cousins Lecture. Glia as the "bad guys": implications for improving clinical pain control and the clinical utility of opioids. Brain, Behavior, and Immunity. 21: 131-46. PMID 17175134 DOI: 10.1016/j.bbi.2006.10.011  1
2007 Ledeboer A, Jekich BM, Sloane EM, Mahoney JH, Langer SJ, Milligan ED, Martin D, Maier SF, Johnson KW, Leinwand LA, Chavez RA, Watkins LR. Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats. Brain, Behavior, and Immunity. 21: 686-98. PMID 17174526 DOI: 10.1016/j.bbi.2006.10.012  1
2007 Bilbo SD, Newsum NJ, Sprunger DB, Watkins LR, Rudy JW, Maier SF. Differential effects of neonatal handling on early life infection-induced alterations in cognition in adulthood. Brain, Behavior, and Immunity. 21: 332-42. PMID 17126527 DOI: 10.1016/j.bbi.2006.10.005  1
2007 Wieseler-Frank J, Jekich BM, Mahoney JH, Bland ST, Maier SF, Watkins LR. A novel immune-to-CNS communication pathway: cells of the meninges surrounding the spinal cord CSF space produce proinflammatory cytokines in response to an inflammatory stimulus. Brain, Behavior, and Immunity. 21: 711-8. PMID 16989980 DOI: 10.1016/j.bbi.2006.07.004  1
2007 Frank MG, Baratta MV, Sprunger DB, Watkins LR, Maier SF. Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses. Brain, Behavior, and Immunity. 21: 47-59. PMID 16647243 DOI: 10.1016/j.bbi.2006.03.005  1
2007 Watkins LR. Immune and glial regulation of pain Brain, Behavior, and Immunity. 21: 519-521. DOI: 10.1016/j.bbi.2006.12.001  1
2007 Watkins LR, Wieseler-Frank J, Hutchinson MR, Ledeboer A, Spataro L, Milligan ED, Sloane EM, Maier SF. Neuroimmune interactions and pain: The role of immune and glial cells Psychoneuroimmunology, Two-Volume Set. 1: 393-414. DOI: 10.1016/B978-012088576-3/50023-X  1
2006 Watkins LR, Wieseler-Frank J, Milligan ED, Johnston I, Maier SF. Chapter 22 Contribution of glia to pain processing in health and disease. Handbook of Clinical Neurology. 81: 309-23. PMID 18808844 DOI: 10.1016/S0072-9752(06)80026-6  1
2006 Ledeboer A, Liu T, Shumilla JA, Mahoney JH, Vijay S, Gross MI, Vargas JA, Sultzbaugh L, Claypool MD, Sanftner LM, Watkins LR, Johnson KW. The glial modulatory drug AV411 attenuates mechanical allodynia in rat models of neuropathic pain. Neuron Glia Biology. 2: 279-91. PMID 18176632 DOI: 10.1017/S1740925X0700035X  1
2006 Milligan ED, Soderquist RG, Malone SM, Mahoney JH, Hughes TS, Langer SJ, Sloane EM, Maier SF, Leinwand LA, Watkins LR, Mahoney MJ. Intrathecal polymer-based interleukin-10 gene delivery for neuropathic pain. Neuron Glia Biology. 2: 293-308. PMID 18079973 DOI: 10.1017/S1740925X07000488  1
2006 Maier SF, Amat J, Baratta MV, Paul E, Watkins LR. Behavioral control, the medial prefrontal cortex, and resilience. Dialogues in Clinical Neuroscience. 8: 397-406. PMID 17290798  1
2006 Amat J, Paul E, Zarza C, Watkins LR, Maier SF. Previous experience with behavioral control over stress blocks the behavioral and dorsal raphe nucleus activating effects of later uncontrollable stress: role of the ventral medial prefrontal cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 13264-72. PMID 17182776 DOI: 10.1523/JNEUROSCI.3630-06.2006  1
2006 Ledeboer A, Mahoney JH, Milligan ED, Martin D, Maier SF, Watkins LR. Spinal cord glia and interleukin-1 do not appear to mediate persistent allodynia induced by intramuscular acidic saline in rats. The Journal of Pain : Official Journal of the American Pain Society. 7: 757-67. PMID 17018336 DOI: 10.1016/j.jpain.2006.04.001  1
2006 Milligan ED, Sloane EM, Langer SJ, Hughes TS, Jekich BM, Frank MG, Mahoney JH, Levkoff LH, Maier SF, Cruz PE, Flotte TR, Johnson KW, Mahoney MM, Chavez RA, Leinwand LA, ... Watkins LR, et al. Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain. Pain. 126: 294-308. PMID 16949747 DOI: 10.1016/j.pain.2006.07.009  1
2006 Banks WA, Watkins LR. Mediation of chronic pain: not by neurons alone. Pain. 124: 1-2. PMID 16630695 DOI: 10.1016/j.pain.2006.03.001  1
2006 Bland ST, Schmid MJ, Greenwood BN, Watkins LR, Maier SF. Behavioral control of the stressor modulates stress-induced changes in neurogenesis and fibroblast growth factor-2. Neuroreport. 17: 593-7. PMID 16603918 DOI: 10.1097/00001756-200604240-00008  1
2006 Der-Avakian A, Bland ST, Schmid MJ, Watkins LR, Spencer RL, Maier SF. The role of glucocorticoids in the uncontrollable stress-induced potentiation of nucleus accumbens shell dopamine and conditioned place preference responses to morphine. Psychoneuroendocrinology. 31: 653-63. PMID 16584846 DOI: 10.1016/j.psyneuen.2006.02.004  1
2006 Bilbo SD, Rudy JW, Watkins LR, Maier SF. A behavioural characterization of neonatal infection-facilitated memory impairment in adult rats. Behavioural Brain Research. 169: 39-47. PMID 16413067 DOI: 10.1016/j.bbr.2005.12.002  1
2006 Frank MG, Wieseler-Frank JL, Watkins LR, Maier SF. Rapid isolation of highly enriched and quiescent microglia from adult rat hippocampus: immunophenotypic and functional characteristics. Journal of Neuroscience Methods. 151: 121-30. PMID 16125247 DOI: 10.1016/j.jneumeth.2005.06.026  1
2006 Barrientos RM, Higgins EA, Biedenkapp JC, Sprunger DB, Wright-Hardesty KJ, Watkins LR, Rudy JW, Maier SF. Peripheral infection and aging interact to impair hippocampal memory consolidation. Neurobiology of Aging. 27: 723-32. PMID 15893410 DOI: 10.1016/j.neurobiolaging.2005.03.010  1
2006 Frank MG, Barrientos RM, Biedenkapp JC, Rudy JW, Watkins LR, Maier SF. mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging. Neurobiology of Aging. 27: 717-22. PMID 15890435 DOI: 10.1016/j.neurobiolaging.2005.03.013  1
2005 Milligan E, Zapata V, Schoeniger D, Chacur M, Green P, Poole S, Martin D, Maier SF, Watkins LR. An initial investigation of spinal mechanisms underlying pain enhancement induced by fractalkine, a neuronally released chemokine. The European Journal of Neuroscience. 22: 2775-82. PMID 16324111 DOI: 10.1111/j.1460-9568.2005.04470.x  1
2005 Ledeboer A, Gamanos M, Lai W, Martin D, Maier SF, Watkins LR, Quan N. Involvement of spinal cord nuclear factor kappaB activation in rat models of proinflammatory cytokine-mediated pain facilitation. The European Journal of Neuroscience. 22: 1977-86. PMID 16262636 DOI: 10.1111/j.1460-9568.2005.04379.x  1
2005 Watkins LR, Hutchinson MR, Johnston IN, Maier SF. Glia: novel counter-regulators of opioid analgesia. Trends in Neurosciences. 28: 661-9. PMID 16246435 DOI: 10.1016/j.tins.2005.10.001  1
2005 Wieseler-Frank J, Maier SF, Watkins LR. Central proinflammatory cytokines and pain enhancement. Neuro-Signals. 14: 166-74. PMID 16215299 DOI: 10.1159/000087655  1
2005 Bilbo SD, Biedenkapp JC, Der-Avakian A, Watkins LR, Rudy JW, Maier SF. Neonatal infection-induced memory impairment after lipopolysaccharide in adulthood is prevented via caspase-1 inhibition. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 8000-9. PMID 16135757 DOI: 10.1523/JNEUROSCI.1748-05.2005  1
2005 Bland ST, Schmid MJ, Der-Avakian A, Watkins LR, Spencer RL, Maier SF. Expression of c-fos and BDNF mRNA in subregions of the prefrontal cortex of male and female rats after acute uncontrollable stress. Brain Research. 1051: 90-9. PMID 15993862 DOI: 10.1016/j.brainres.2005.05.065  1
2005 Takase LF, Nogueira MI, Bland ST, Baratta M, Watkins LR, Maier SF, Fornal CA, Jacobs BL. Effect of number of tailshocks on learned helplessness and activation of serotonergic and noradrenergic neurons in the rat. Behavioural Brain Research. 162: 299-306. PMID 15913803 DOI: 10.1016/j.bbr.2005.04.008  1
2005 Maier SF, Watkins LR. Stressor controllability and learned helplessness: the roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor. Neuroscience and Biobehavioral Reviews. 29: 829-41. PMID 15893820 DOI: 10.1016/j.neubiorev.2005.03.021  1
2005 Milligan ED, Langer SJ, Sloane EM, He L, Wieseler-Frank J, O'Connor K, Martin D, Forsayeth JR, Maier SF, Johnson K, Chavez RA, Leinwand LA, Watkins LR. Controlling pathological pain by adenovirally driven spinal production of the anti-inflammatory cytokine, interleukin-10. The European Journal of Neuroscience. 21: 2136-48. PMID 15869510 DOI: 10.1111/j.1460-9568.2005.04057.x  1
2005 Ledeboer A, Sloane EM, Milligan ED, Frank MG, Mahony JH, Maier SF, Watkins LR. Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation. Pain. 115: 71-83. PMID 15836971 DOI: 10.1016/j.pain.2005.02.009  1
2005 Der-Avakian A, Will MJ, Bland ST, Deak T, Nguyen KT, Schmid MJ, Spencer RL, Watkins LR, Maier SF. Surgical and pharmacological suppression of glucocorticoids prevents the enhancement of morphine conditioned place preference by uncontrollable stress in rats. Psychopharmacology. 179: 409-17. PMID 15821955 DOI: 10.1007/s00213-004-2041-1  1
2005 Milligan ED, Sloane EM, Langer SJ, Cruz PE, Chacur M, Spataro L, Wieseler-Frank J, Hammack SE, Maier SF, Flotte TR, Forsayeth JR, Leinwand LA, Chavez R, Watkins LR. Controlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10. Molecular Pain. 1: 9. PMID 15813997 DOI: 10.1186/1744-8069-1-9  1
2005 Twining CM, Sloane EM, Schoeniger DK, Milligan ED, Martin D, Marsh H, Maier SF, Watkins LR. Activation of the spinal cord complement cascade might contribute to mechanical allodynia induced by three animal models of spinal sensitization. The Journal of Pain : Official Journal of the American Pain Society. 6: 174-83. PMID 15772911 DOI: 10.1016/j.jpain.2004.11.011  1
2005 Bilbo SD, Levkoff LH, Mahoney JH, Watkins LR, Rudy JW, Maier SF. Neonatal infection induces memory impairments following an immune challenge in adulthood. Behavioral Neuroscience. 119: 293-301. PMID 15727533 DOI: 10.1037/0735-7044.119.1.293  1
2005 Amat J, Baratta MV, Paul E, Bland ST, Watkins LR, Maier SF. Medial prefrontal cortex determines how stressor controllability affects behavior and dorsal raphe nucleus. Nature Neuroscience. 8: 365-71. PMID 15696163 DOI: 10.1038/nn1399  1
2005 Wieseler-Frank J, Maier SF, Watkins LR. Immune-to-brain communication dynamically modulates pain: physiological and pathological consequences. Brain, Behavior, and Immunity. 19: 104-11. PMID 15664782 DOI: 10.1016/j.bbi.2004.08.004  1
2005 Watkins LR, Maier SF. Immune regulation of central nervous system functions: from sickness responses to pathological pain. Journal of Internal Medicine. 257: 139-55. PMID 15656873 DOI: 10.1111/j.1365-2796.2004.01443.x  1
2004 O'Connor KA, Ginsberg AB, Maksimova E, Wieseler Frank JL, Johnson JD, Spencer RL, Campeau S, Watkins LR, Maier SF. Stress-induced sensitization of the hypothalamic-pituitary adrenal axis is associated with alterations of hypothalamic and pituitary gene expression. Neuroendocrinology. 80: 252-63. PMID 15627803 DOI: 10.1159/000082876  1
2004 Bland ST, Schmid MJ, Watkins LR, Maier SF. Prefrontal cortex serotonin, stress, and morphine-induced nucleus accumbens dopamine. Neuroreport. 15: 2637-41. PMID 15570168 DOI: 10.1097/00001756-200412030-00016  1
2004 Amat J, Tamblyn JP, Paul ED, Bland ST, Amat P, Foster AC, Watkins LR, Maier SF. Microinjection of urocortin 2 into the dorsal raphe nucleus activates serotonergic neurons and increases extracellular serotonin in the basolateral amygdala. Neuroscience. 129: 509-19. PMID 15541873 DOI: 10.1016/j.neuroscience.2004.07.052  1
2004 Milligan ED, Zapata V, Chacur M, Schoeniger D, Biedenkapp J, O'Connor KA, Verge GM, Chapman G, Green P, Foster AC, Naeve GS, Maier SF, Watkins LR. Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive facilitation in rats. The European Journal of Neuroscience. 20: 2294-302. PMID 15525271 DOI: 10.1111/j.1460-9568.2004.03709.x  1
2004 Spataro LE, Sloane EM, Milligan ED, Wieseler-Frank J, Schoeniger D, Jekich BM, Barrientos RM, Maier SF, Watkins LR. Spinal gap junctions: potential involvement in pain facilitation. The Journal of Pain : Official Journal of the American Pain Society. 5: 392-405. PMID 15501197 DOI: 10.1016/j.jpain.2004.06.006  1
2004 Steiner AA, Dogan MD, Ivanov AI, Patel S, Rudaya AY, Jennings DH, Orchinik M, Pace TW, O'connor KA, Watkins LR, Romanovsky AA. A new function of the leptin receptor: mediation of the recovery from lipopolysaccharide-induced hypothermia. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1949-51. PMID 15388670 DOI: 10.1096/fj.04-2295fje  1
2004 Barrientos RM, Sprunger DB, Campeau S, Watkins LR, Rudy JW, Maier SF. BDNF mRNA expression in rat hippocampus following contextual learning is blocked by intrahippocampal IL-1beta administration. Journal of Neuroimmunology. 155: 119-26. PMID 15342202 DOI: 10.1016/j.jneuroim.2004.06.009  1
2004 Verge GM, Milligan ED, Maier SF, Watkins LR, Naeve GS, Foster AC. Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions. The European Journal of Neuroscience. 20: 1150-60. PMID 15341587 DOI: 10.1111/j.1460-9568.2004.03593.x  1
2004 Chacur M, Gutiérrez JM, Milligan ED, Wieseler-Frank J, Britto LR, Maier SF, Watkins LR, Cury Y. Snake venom components enhance pain upon subcutaneous injection: an initial examination of spinal cord mediators. Pain. 111: 65-76. PMID 15327810 DOI: 10.1016/j.pain.2004.06.001  1
2004 Johnston IN, Milligan ED, Wieseler-Frank J, Frank MG, Zapata V, Campisi J, Langer S, Martin D, Green P, Fleshner M, Leinwand L, Maier SF, Watkins LR. A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 7353-65. PMID 15317861 DOI: 10.1523/JNEUROSCI.1850-04.2004  1
2004 Holguin A, O'Connor KA, Biedenkapp J, Campisi J, Wieseler-Frank J, Milligan ED, Hansen MK, Spataro L, Maksimova E, Bravmann C, Martin D, Fleshner M, Maier SF, Watkins LR. HIV-1 gp120 stimulates proinflammatory cytokine-mediated pain facilitation via activation of nitric oxide synthase-I (nNOS). Pain. 110: 517-30. PMID 15288392 DOI: 10.1016/j.pain.2004.02.018  1
2004 Johnson JD, O'Connor KA, Watkins LR, Maier SF. The role of IL-1beta in stress-induced sensitization of proinflammatory cytokine and corticosterone responses. Neuroscience. 127: 569-77. PMID 15283957 DOI: 10.1016/j.neuroscience.2004.05.046  1
2004 Twining CM, Sloane EM, Milligan ED, Chacur M, Martin D, Poole S, Marsh H, Maier SF, Watkins LR. Peri-sciatic proinflammatory cytokines, reactive oxygen species, and complement induce mirror-image neuropathic pain in rats. Pain. 110: 299-309. PMID 15275780 DOI: 10.1016/j.pain.2004.04.008  1
2004 Takase LF, Nogueira MI, Baratta M, Bland ST, Watkins LR, Maier SF, Fornal CA, Jacobs BL. Inescapable shock activates serotonergic neurons in all raphe nuclei of rat. Behavioural Brain Research. 153: 233-9. PMID 15219724 DOI: 10.1016/j.bbr.2003.12.020  1
2004 Bland ST, Twining C, Schmid MJ, Der-Avakian A, Watkins LR, Maier SF. Stress potentiation of morphine-induced dopamine efflux in the nucleus accumbens shell is dependent upon stressor uncontrollability and is mediated by the dorsal raphe nucleus. Neuroscience. 126: 705-15. PMID 15183519 DOI: 10.1016/j.neuroscience.2004.04.025  1
2004 Day HE, Greenwood BN, Hammack SE, Watkins LR, Fleshner M, Maier SF, Campeau S. Differential expression of 5HT-1A, alpha 1b adrenergic, CRF-R1, and CRF-R2 receptor mRNA in serotonergic, gamma-aminobutyric acidergic, and catecholaminergic cells of the rat dorsal raphe nucleus. The Journal of Comparative Neurology. 474: 364-78. PMID 15174080 DOI: 10.1002/cne.20138  1
2004 Wieseler-Frank J, Maier SF, Watkins LR. Glial activation and pathological pain. Neurochemistry International. 45: 389-95. PMID 15145553 DOI: 10.1016/j.neuint.2003.09.009  1
2004 Milligan ED, Maier SF, Watkins LR. Sciatic inflammatory neuropathy in the rat: surgical procedures, induction of inflammation, and behavioral testing. Methods in Molecular Medicine. 99: 67-89. PMID 15131330 DOI: 10.1385/1-59259-770-X:067  1
2004 Hammack SE, Richey KJ, Watkins LR, Maier SF. Chemical lesion of the bed nucleus of the stria terminalis blocks the behavioral consequences of uncontrollable stress. Behavioral Neuroscience. 118: 443-8. PMID 15113272 DOI: 10.1037/0735-7044.118.2.443  1
2004 Chacur M, Milligan ED, Sloan EM, Wieseler-Frank J, Barrientos RM, Martin D, Poole S, Lomonte B, Gutiérrez JM, Maier SF, Cury Y, Watkins LR. Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: involvement of spinal cord glia, proinflammatory cytokines and nitric oxide. Pain. 108: 180-91. PMID 15109522 DOI: 10.1016/j.pain.2003.12.023  1
2004 O'Connor KA, Holguin A, Hansen MK, Maier SF, Watkins LR. A method for measuring multiple cytokines from small samples. Brain, Behavior, and Immunity. 18: 274-80. PMID 15050654 DOI: 10.1016/j.bbi.2003.09.009  1
2004 Will MJ, Der-Avakian A, Bland ST, Grahn RE, Hammack SE, Sparks PD, Pepin JL, Watkins LR, Maier SF. Electrolytic lesions and pharmacological inhibition of the dorsal raphe nucleus prevent stressor potentiation of morphine conditioned place preference in rats. Psychopharmacology. 171: 191-8. PMID 13680080 DOI: 10.1007/s00213-003-1572-1  1
2003 Gazda LS, Smith T, Watkins LR, Maier SF, Fleshner M. Stressor exposure produces long-term reductions in antigen-specific T and B cell responses. Stress (Amsterdam, Netherlands). 6: 259-67. PMID 14660058 DOI: 10.1080/10253890310001594441  1
2003 Hammack SE, Pepin JL, DesMarteau JS, Watkins LR, Maier SF. Low doses of corticotropin-releasing hormone injected into the dorsal raphe nucleus block the behavioral consequences of uncontrollable stress. Behavioural Brain Research. 147: 55-64. PMID 14659570 DOI: 10.1016/S0166-4328(03)00133-5  1
2003 Watkins LR, Maier SF. Glia: a novel drug discovery target for clinical pain. Nature Reviews. Drug Discovery. 2: 973-85. PMID 14654796 DOI: 10.1038/nrd1251  1
2003 Dworkin RH, Backonja M, Rowbotham MC, Allen RR, Argoff CR, Bennett GJ, Bushnell MC, Farrar JT, Galer BS, Haythornthwaite JA, Hewitt DJ, Loeser JD, Max MB, Saltarelli M, Schmader KE, ... ... Watkins LR, et al. Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations. Archives of Neurology. 60: 1524-34. PMID 14623723 DOI: 10.1001/archneur.60.11.1524  1
2003 O'Connor KA, Hansen MK, Rachal Pugh C, Deak MM, Biedenkapp JC, Milligan ED, Johnson JD, Wang H, Maier SF, Tracey KJ, Watkins LR. Further characterization of high mobility group box 1 (HMGB1) as a proinflammatory cytokine: central nervous system effects. Cytokine. 24: 254-65. PMID 14609567 DOI: 10.1016/j.cyto.2003.08.001  1
2003 Barrientos RM, Sprunger DB, Campeau S, Higgins EA, Watkins LR, Rudy JW, Maier SF. Brain-derived neurotrophic factor mRNA downregulation produced by social isolation is blocked by intrahippocampal interleukin-1 receptor antagonist. Neuroscience. 121: 847-53. PMID 14580934 DOI: 10.1016/S0306-4522(03)00564-5  1
2003 O'Connor KA, Johnson JD, Hansen MK, Wieseler Frank JL, Maksimova E, Watkins LR, Maier SF. Peripheral and central proinflammatory cytokine response to a severe acute stressor. Brain Research. 991: 123-32. PMID 14575884 DOI: 10.1016/j.brainres.2003.08.006  1
2003 Brennan FX, Grahn RE, Watkins LR, Maier SF. Serum cholesterol levels and stressor controllability in rats. Physiology & Behavior. 79: 757-60. PMID 12954419 DOI: 10.1016/S0031-9384(03)00210-5  1
2003 Campisi J, Hansen MK, O'Connor KA, Biedenkapp JC, Watkins LR, Maier SF, Fleshner M. Circulating cytokines and endotoxin are not necessary for the activation of the sickness or corticosterone response produced by peripheral E. coli challenge. Journal of Applied Physiology (Bethesda, Md. : 1985). 95: 1873-82. PMID 12871965 DOI: 10.1152/japplphysiol.00371.2003  1
2003 Bland ST, Hargrave D, Pepin JL, Amat J, Watkins LR, Maier SF. Stressor controllability modulates stress-induced dopamine and serotonin efflux and morphine-induced serotonin efflux in the medial prefrontal cortex. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 1589-96. PMID 12784102 DOI: 10.1038/sj.npp.1300206  1
2003 Bland ST, Twining C, Watkins LR, Maier SF. Stressor controllability modulates stress-induced serotonin but not dopamine efflux in the nucleus accumbens shell. Synapse (New York, N.Y.). 49: 206-8. PMID 12774305 DOI: 10.1002/syn.10229  1
2003 O'Connor KA, Johnson JD, Hammack SE, Brooks LM, Spencer RL, Watkins LR, Maier SF. Inescapable shock induces resistance to the effects of dexamethasone. Psychoneuroendocrinology. 28: 481-500. PMID 12689607 DOI: 10.1016/S0306-4530(02)00035-5  1
2003 Watkins LR, Milligan ED, Maier SF. Glial proinflammatory cytokines mediate exaggerated pain states: implications for clinical pain. Advances in Experimental Medicine and Biology. 521: 1-21. PMID 12617561  1
2003 Maier SF, Watkins LR. Immune-to-central nervous system communication and its role in modulating pain and cognition: Implications for cancer and cancer treatment. Brain, Behavior, and Immunity. 17: S125-31. PMID 12615198 DOI: 10.1016/S0889-1591(02)00079-X  1
2003 Milligan ED, Twining C, Chacur M, Biedenkapp J, O'Connor K, Poole S, Tracey K, Martin D, Maier SF, Watkins LR. Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 1026-40. PMID 12574433  1
2003 Hammack SE, Schmid MJ, LoPresti ML, Der-Avakian A, Pellymounter MA, Foster AC, Watkins LR, Maier SF. Corticotropin releasing hormone type 2 receptors in the dorsal raphe nucleus mediate the behavioral consequences of uncontrollable stress. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 1019-25. PMID 12574432  1
2003 Johnson JD, O'Connor KA, Hansen MK, Watkins LR, Maier SF. Effects of prior stress on LPS-induced cytokine and sickness responses. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 284: R422-32. PMID 12399247 DOI: 10.1152/ajpregu.00230.2002  1
2002 Watkins LR, Maier SF. Beyond neurons: evidence that immune and glial cells contribute to pathological pain states. Physiological Reviews. 82: 981-1011. PMID 12270950 DOI: 10.1152/physrev.00011.2002  1
2002 Grahn RE, Hammack SE, Will MJ, O'Connor KA, Deak T, Sparks PD, Watkins LR, Maier SF. Blockade of alpha1 adrenoreceptors in the dorsal raphe nucleus prevents enhanced conditioned fear and impaired escape performance following uncontrollable stressor exposure in rats. Behavioural Brain Research. 134: 387-92. PMID 12191825 DOI: 10.1016/S0166-4328(02)00061-X  1
2002 Barrientos RM, Higgins EA, Sprunger DB, Watkins LR, Rudy JW, Maier SF. Memory for context is impaired by a post context exposure injection of interleukin-1 beta into dorsal hippocampus. Behavioural Brain Research. 134: 291-8. PMID 12191816 DOI: 10.1016/S0166-4328(02)00043-8  0.8
2002 Johnson JD, O'Connor KA, Deak T, Stark M, Watkins LR, Maier SF. Prior stressor exposure sensitizes LPS-induced cytokine production. Brain, Behavior, and Immunity. 16: 461-76. PMID 12096891 DOI: 10.1006/brbi.2001.0638  1
2002 Moraska A, Campisi J, Nguyen KT, Maier SF, Watkins LR, Fleshner M. Elevated IL-1beta contributes to antibody suppression produced by stress. Journal of Applied Physiology (Bethesda, Md. : 1985). 93: 207-15. PMID 12070207 DOI: 10.1152/japplphysiol.01151.2001  1
2002 Hammack SE, Richey KJ, Schmid MJ, LoPresti ML, Watkins LR, Maier SF. The role of corticotropin-releasing hormone in the dorsal raphe nucleus in mediating the behavioral consequences of uncontrollable stress. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 1020-6. PMID 11826130  1
2002 Johnson JD, O'Connor KA, Deak T, Spencer RL, Watkins LR, Maier SF. Prior stressor exposure primes the HPA axis. Psychoneuroendocrinology. 27: 353-65. PMID 11818171 DOI: 10.1016/S0306-4530(01)00057-9  1
2002 Will MJ, Der-Avakian A, Pepin JL, Durkan BT, Watkins LR, Maier SF. Modulation of the locomotor properties of morphine and amphetamine by uncontrollable stress. Pharmacology, Biochemistry, and Behavior. 71: 345-51. PMID 11812543 DOI: 10.1016/S0091-3057(01)00721-3  1
2001 Milligan ED, O'Connor KA, Armstrong CB, Hansen MK, Martin D, Tracey KJ, Maier SF, Watkins LR. Systemic administration of CNI-1493, a p38 mitogen-activated protein kinase inhibitor, blocks intrathecal human immunodeficiency virus-1 gp120-induced enhanced pain states in rats. The Journal of Pain : Official Journal of the American Pain Society. 2: 326-33. PMID 14622812 DOI: 10.1054/jpai.2001.26174  1
2001 Gazda LS, Milligan ED, Hansen MK, Twining CM, Poulos NM, Chacur M, O'Connor KA, Armstrong C, Maier SF, Watkins LR, Myers RR. Sciatic inflammatory neuritis (SIN): behavioral allodynia is paralleled by peri-sciatic proinflammatory cytokine and superoxide production. Journal of the Peripheral Nervous System : Jpns. 6: 111-29. PMID 11817330 DOI: 10.1046/j.1529-8027.2001.006001111.x  1
2001 Chacur M, Milligan ED, Gazda LS, Armstrong C, Wang H, Tracey KJ, Maier SF, Watkins LR. A new model of sciatic inflammatory neuritis (SIN): induction of unilateral and bilateral mechanical allodynia following acute unilateral peri-sciatic immune activation in rats. Pain. 94: 231-44. PMID 11731060 DOI: 10.1016/S0304-3959(01)00354-2  1
2001 Amat J, Sparks PD, Matus-Amat P, Griggs J, Watkins LR, Maier SF. The role of the habenular complex in the elevation of dorsal raphe nucleus serotonin and the changes in the behavioral responses produced by uncontrollable stress. Brain Research. 917: 118-26. PMID 11602236  1
2001 Watkins LR, Milligan ED, Maier SF. Spinal cord glia: new players in pain. Pain. 93: 201-5. PMID 11514078 DOI: 10.1016/S0304-3959(01)00359-1  1
2001 Watkins LR, Milligan ED, Maier SF. Glial activation: a driving force for pathological pain. Trends in Neurosciences. 24: 450-5. PMID 11476884 DOI: 10.1016/S0166-2236(00)01854-3  1
2001 Milligan ED, O'Connor KA, Nguyen KT, Armstrong CB, Twining C, Gaykema RP, Holguin A, Martin D, Maier SF, Watkins LR. Intrathecal HIV-1 envelope glycoprotein gp120 induces enhanced pain states mediated by spinal cord proinflammatory cytokines. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 2808-19. PMID 11306633  1
2001 Goehler LE, Gaykema RP, Hansen MK, Kleiner JL, Maier SF, Watkins LR. Staphylococcal enterotoxin B induces fever, brain c-Fos expression, and serum corticosterone in rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 280: R1434-9. PMID 11294765  1
2001 Hansen MK, O'Connor KA, Goehler LE, Watkins LR, Maier SF. The contribution of the vagus nerve in interleukin-1beta-induced fever is dependent on dose. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 280: R929-34. PMID 11247812  1
2001 Fleshner M, Deak T, Nguyen KT, Watkins LR, Maier SF. Endogenous glucocorticoids play a positive regulatory role in the anti-keyhole limpet hemocyanin in vivo antibody response. Journal of Immunology (Baltimore, Md. : 1950). 166: 3813-9. PMID 11238624  1
2001 Rachal Pugh C, Fleshner M, Watkins LR, Maier SF, Rudy JW. The immune system and memory consolidation: a role for the cytokine IL-1beta. Neuroscience and Biobehavioral Reviews. 25: 29-41. PMID 11166076 DOI: 10.1016/S0149-7634(00)00048-8  1
2000 Hansen MK, Daniels S, Goehler LE, Gaykema RP, Maier SF, Watkins LR. Subdiaphragmatic vagotomy does not block intraperitoneal lipopolysaccharide-induced fever. Autonomic Neuroscience : Basic & Clinical. 85: 83-7. PMID 11189031 DOI: 10.1016/S1566-0702(00)00224-1  1
2000 Gaykema RP, Goehler LE, Hansen MK, Maier SF, Watkins LR. Subdiaphragmatic vagotomy blocks interleukin-1beta-induced fever but does not reduce IL-1beta levels in the circulation. Autonomic Neuroscience : Basic & Clinical. 85: 72-7. PMID 11189029  1
2000 Goehler LE, Gaykema RP, Hansen MK, Anderson K, Maier SF, Watkins LR. Vagal immune-to-brain communication: a visceral chemosensory pathway. Autonomic Neuroscience : Basic & Clinical. 85: 49-59. PMID 11189026 DOI: 10.1016/S1566-0702(00)00219-8  1
2000 Hansen MK, Nguyen KT, Goehler LE, Gaykema RP, Fleshner M, Maier SF, Watkins LR. Effects of vagotomy on lipopolysaccharide-induced brain interleukin-1beta protein in rats. Autonomic Neuroscience : Basic & Clinical. 85: 119-26. PMID 11189018 DOI: 10.1016/S1566-0702(00)00230-7  1
2000 Grahn RE, Watkins LR, Maier SF. Impaired escape performance and enhanced conditioned fear in rats following exposure to an uncontrollable stressor are mediated by glutamate and nitric oxide in the dorsal raphe nucleus. Behavioural Brain Research. 112: 33-41. PMID 10862933  1
2000 Borovikova LV, Ivanova S, Zhang M, Yang H, Botchkina GI, Watkins LR, Wang H, Abumrad N, Eaton JW, Tracey KJ. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature. 405: 458-62. PMID 10839541 DOI: 10.1038/35013070  1
2000 Van Dam AM, Bol JG, Gaykema RP, Goehler LE, Maier SF, Watkins LR, Tilders FJ. Vagotomy does not inhibit high dose lipopolysaccharide-induced interleukin-1beta immunoreactivity in rat brain and pituitary gland. Neuroscience Letters. 285: 169-72. PMID 10806313  1
2000 Watkins LR, Maier SF. The pain of being sick: implications of immune-to-brain communication for understanding pain. Annual Review of Psychology. 51: 29-57. PMID 10751964 DOI: 10.1146/annurev.psych.51.1.29  1
2000 Milligan ED, Mehmert KK, Hinde JL, Harvey LO, Martin D, Tracey KJ, Maier SF, Watkins LR. Thermal hyperalgesia and mechanical allodynia produced by intrathecal administration of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein, gp120. Brain Research. 861: 105-16. PMID 10751570 DOI: 10.1016/S0006-8993(00)02050-3  1
2000 Pugh CR, Johnson JD, Martin D, Rudy JW, Maier SF, Watkins LR. Human immunodeficiency virus-1 coat protein gp120 impairs contextual fear conditioning: a potential role in AIDS related learning and memory impairments. Brain Research. 861: 8-15. PMID 10751560 DOI: 10.1016/S0006-8993(99)02445-2  1
2000 Nguyen KT, Deak T, Will MJ, Hansen MK, Hunsaker BN, Fleshner M, Watkins LR, Maier SF. Timecourse and corticosterone sensitivity of the brain, pituitary, and serum interleukin-1beta protein response to acute stress. Brain Research. 859: 193-201. PMID 10719064 DOI: 10.1016/S0006-8993(99)02443-9  1
2000 Hansen MK, Nguyen KT, Fleshner M, Goehler LE, Gaykema RP, Maier SF, Watkins LR. Effects of vagotomy on serum endotoxin, cytokines, and corticosterone after intraperitoneal lipopolysaccharide. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 278: R331-6. PMID 10666132  1
1999 Deak T, Nguyen KT, Ehrlich AL, Watkins LR, Spencer RL, Maier SF, Licinio J, Wong ML, Chrousos GP, Webster E, Gold PW. The Impact of the Nonpeptide Corticotropin-Releasing Hormone Antagonist Antalarmin on Behavioral and Endocrine Responses to Stress* *This research was supported by NIMH Grant MH-50479 and the Undergraduate Research Opportunities Program at the University of Colorado at Boulder. Endocrinology. 140: 79-86. PMID 28200658 DOI: 10.1210/endo.140.1.6415  1
1999 Deak T, Nguyen KT, Cotter CS, Fleshner M, Watkins LR, Maier SF, Spencer RL. Long-term changes in mineralocorticoid and glucocorticoid receptor occupancy following exposure to an acute stressor. Brain Research. 847: 211-20. PMID 10575090 DOI: 10.1016/S0006-8993(99)02050-8  1
1999 Milligan ED, Hinde JL, Mehmert KK, Maier SF, Watkins LR. A method for increasing the viability of the external portion of lumbar catheters placed in the spinal subarachnoid space of rats. Journal of Neuroscience Methods. 90: 81-6. PMID 10517276 DOI: 10.1016/S0165-0270(99)00075-8  1
1999 Grahn RE, Maswood S, McQueen MB, Watkins LR, Maier SF. Opioid-dependent effects of inescapable shock on escape behavior and conditioned fear responding are mediated by the dorsal raphe nucleus. Behavioural Brain Research. 99: 153-67. PMID 10512582 DOI: 10.1016/S0166-4328(98)00101-6  1
1999 Hammack SE, Hartley CE, Lea SE, Maier SF, Watkins LR, Sutton LC. Inescapable shock-induced potentiation of morphine analgesia in rats: sites of action. Behavioral Neuroscience. 113: 795-803. PMID 10495087 DOI: 10.1037/0735-7044.113.4.795  1
1999 Deak T, Nguyen KT, Fleshner M, Watkins LR, Maier SF. Acute stress may facilitate recovery from a subcutaneous bacterial challenge. Neuroimmunomodulation. 6: 344-54. PMID 10474053 DOI: 10.1159/000026394  1
1999 Watkins LR, Hansen MK, Nguyen KT, Lee JE, Maier SF. Dynamic regulation of the proinflammatory cytokine, interleukin-1beta: molecular biology for non-molecular biologists. Life Sciences. 65: 449-81. PMID 10462074 DOI: 10.1016/S0024-3205(99)00095-8  1
1999 Maier SF, Nguyen KT, Deak T, Milligan ED, Watkins LR. Stress, learned helplessness, and brain interleukin-1 beta. Advances in Experimental Medicine and Biology. 461: 235-49. PMID 10442176 DOI: 10.1007/978-0-585-37970-8_13  1
1999 Watkins LR, Nguyen KT, Lee JE, Maier SF. Dynamic regulation of proinflammatory cytokines. Advances in Experimental Medicine and Biology. 461: 153-78. PMID 10442173 DOI: 10.1007/978-0-585-37970-8_10  1
1999 Watkins LR, Maier SF. Implications of immune-to-brain communication for sickness and pain. Proceedings of the National Academy of Sciences of the United States of America. 96: 7710-3. PMID 10393885 DOI: 10.1073/pnas.96.14.7710  1
1999 Grahn RE, Will MJ, Hammack SE, Maswood S, McQueen MB, Watkins LR, Maier SF. Activation of serotonin-immunoreactive cells in the dorsal raphe nucleus in rats exposed to an uncontrollable stressor. Brain Research. 826: 35-43. PMID 10216194 DOI: 10.1016/S0006-8993(99)01208-1  1
1999 Goehler LE, Gaykema RP, Nguyen KT, Lee JE, Tilders FJ, Maier SF, Watkins LR. Interleukin-1beta in immune cells of the abdominal vagus nerve: a link between the immune and nervous systems? The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 2799-806. PMID 10087091  1
1999 Helmreich DL, Watkins LR, Deak T, Maier SF, Akil H, Watson SJ. The effect of stressor controllability on stress-induced neuropeptide mRNA expression within the paraventricular nucleus of the hypothalamus. Journal of Neuroendocrinology. 11: 121-8. PMID 10048467 DOI: 10.1046/j.1365-2826.1999.00300.x  1
1999 Deak T, Nguyen KT, Ehrlich AL, Watkins LR, Spencer RL, Maier SF, Licinio J, Wong ML, Chrousos GP, Webster E, Gold PW. The impact of the nonpeptide corticotropin-releasing hormone antagonist antalarmin on behavioral and endocrine responses to stress. Endocrinology. 140: 79-86. PMID 9886810 DOI: 10.1210/endo.140.1.6415  1
1998 Fleshner M, Nguyen KT, Cotter CS, Watkins LR, Maier SF. Acute stressor exposure both suppresses acquired immunity and potentiates innate immunity. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 275: R870-R878. PMID 29586974 DOI: 10.1152/ajpregu.1998.275.3.R870  1
1998 Amat J, Matus-Amat P, Watkins LR, Maier SF. Escapable and inescapable stress differentially alter extracellular levels of 5-HT in the basolateral amygdala of the rat. Brain Research. 812: 113-20. PMID 9813270 DOI: 10.1016/S0006-8993(98)00960-3  1
1998 Milligan ED, Nguyen KT, Deak T, Hinde JL, Fleshner M, Watkins LR, Maier SF. The long term acute phase-like responses that follow acute stressor exposure are blocked by alpha-melanocyte stimulating hormone. Brain Research. 810: 48-58. PMID 9813238 DOI: 10.1016/S0006-8993(98)00869-5  1
1998 Pugh CR, Kumagawa K, Fleshner M, Watkins LR, Maier SF, Rudy JW. Selective effects of peripheral lipopolysaccharide administration on contextual and auditory-cue fear conditioning. Brain, Behavior, and Immunity. 12: 212-29. PMID 9769157 DOI: 10.1006/brbi.1998.0524  1
1998 Goehler LE, Gaykema RP, Hammack SE, Maier SF, Watkins LR. Interleukin-1 induces c-Fos immunoreactivity in primary afferent neurons of the vagus nerve. Brain Research. 804: 306-10. PMID 9757071 DOI: 10.1016/S0006-8993(98)00685-4  1
1998 Gaykema RP, Goehler LE, Tilders FJ, Bol JG, McGorry M, Fleshner M, Maier SF, Watkins LR. Bacterial endotoxin induces fos immunoreactivity in primary afferent neurons of the vagus nerve. Neuroimmunomodulation. 5: 234-40. PMID 9730691  1
1998 Fleshner M, Nguyen KT, Cotter CS, Watkins LR, Maier SF. Acute stressor exposure both suppresses acquired immunity and potentiates innate immunity. The American Journal of Physiology. 275: R870-8. PMID 9728086  1
1998 Will MJ, Watkins LR, Maier SF. Uncontrollable stress potentiates morphine's rewarding properties. Pharmacology, Biochemistry, and Behavior. 60: 655-64. PMID 9678649 DOI: 10.1016/S0091-3057(98)00027-6  1
1998 Fleshner M, Goehler LE, Schwartz BA, McGorry M, Martin D, Maier SF, Watkins LR. Thermogenic and corticosterone responses to intravenous cytokines (IL-1beta and TNF-alpha) are attenuated by subdiaphragmatic vagotomy. Journal of Neuroimmunology. 86: 134-41. PMID 9663558  1
1998 Amat J, Matus-Amat P, Watkins LR, Maier SF. Escapable and inescapable stress differentially and selectively alter extracellular levels of 5-HT in the ventral hippocampus and dorsal periaqueductal gray of the rat. Brain Research. 797: 12-22. PMID 9630480 DOI: 10.1016/S0006-8993(98)00368-0  1
1998 Maier SF, Goehler LE, Fleshner M, Watkins LR. The role of the vagus nerve in cytokine-to-brain communication. Annals of the New York Academy of Sciences. 840: 289-300. PMID 9629257 DOI: 10.1111/j.1749-6632.1998.tb09569.x  1
1998 Watkins LR, Wiertelak EP, McGorry M, Martinez J, Schwartz B, Sisk D, Maier SF. Neurocircuitry of conditioned inhibition of analgesia: effects of amygdala, dorsal raphe, ventral medullary, and spinal cord lesions on antianalgesia in the rat. Behavioral Neuroscience. 112: 360-78. PMID 9588483 DOI: 10.1037/0735-7044.112.2.360  1
1998 Nguyen KT, Deak T, Owens SM, Kohno T, Fleshner M, Watkins LR, Maier SF. Exposure to acute stress induces brain interleukin-1beta protein in the rat. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 2239-46. PMID 9482808  1
1998 Maswood S, Barter JE, Watkins LR, Maier SF. Exposure to inescapable but not escapable shock increases extracellular levels of 5-HT in the dorsal raphe nucleus of the rat. Brain Research. 783: 115-20. PMID 9479059 DOI: 10.1016/S0006-8993(97)01313-9  1
1998 Maier SF, Watkins LR. Cytokines for psychologists: implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition. Psychological Review. 105: 83-107. PMID 9450372  1
1997 Deak T, Meriwether JL, Fleshner M, Spencer RL, Abouhamze A, Moldawer LL, Grahn RE, Watkins LR, Maier SF. Evidence that brief stress may induce the acute phase response in rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 273: R1998-R2004. PMID 29586945 DOI: 10.1152/ajpregu.1997.273.6.R1998  1
1997 Deak T, Meriwether JL, Fleshner M, Spencer RL, Abouhamze A, Moldawer LL, Grahn RE, Watkins LR, Maier SF. Evidence that brief stress may induce the acute phase response in rats. The American Journal of Physiology. 273: R1998-2004. PMID 9435654  1
1997 Fleshner M, Silbert L, Deak T, Goehler LE, Martin D, Watkins LR, Maier SF. TNF-alpha-induced corticosterone elevation but not serum protein or corticosteroid binding globulin reduction is vagally mediated. Brain Research Bulletin. 44: 701-6. PMID 9421133 DOI: 10.1016/S0361-9230(97)00258-X  1
1997 Sutton LC, Lea SE, Will MJ, Schwartz BA, Hartley CE, Poole JC, Watkins LR, Maier SF. Inescapable shock-induced potentiation of morphine analgesia. Behavioral Neuroscience. 111: 1105-13. PMID 9383528 DOI: 10.1037/0735-7044.111.5.1105  1
1997 Milligan ED, McGorry MM, Fleshner M, Gaykema RP, Goehler LE, Watkins LR, Maier SF. Subdiaphragmatic vagotomy does not prevent fever following intracerebroventricular prostaglandin E2: further evidence for the importance of vagal afferents in immune-to-brain communication. Brain Research. 766: 240-3. PMID 9359608 DOI: 10.1016/S0006-8993(97)00705-1  1
1997 Sutton LC, Grahn RE, Wiertelak EP, Watkins LR, Maier SF. Inescapable shock-induced potentiation of morphine analgesia in rats: involvement of opioid, GABAergic, and serotonergic mechanisms in the dorsal raphe nucleus. Behavioral Neuroscience. 111: 816-24. PMID 9267659 DOI: 10.1037/0735-7044.111.4.816  1
1997 Watkins LR, McGorry M, Schwartz B, Sisk D, Wiertelak EP, Maier SF. Reversal of spinal cord non-opiate analgesia by conditioned anti-analgesia in the rat. Pain. 71: 237-47. PMID 9231866 DOI: 10.1016/S0304-3959(97)03375-7  1
1997 Watkins LR, Martin D, Ulrich P, Tracey KJ, Maier SF. Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat. Pain. 71: 225-35. PMID 9231865  1
1997 Goehler LE, Relton JK, Dripps D, Kiechle R, Tartaglia N, Maier SF, Watkins LR. Vagal paraganglia bind biotinylated interleukin-1 receptor antagonist: a possible mechanism for immune-to-brain communication. Brain Research Bulletin. 43: 357-64. PMID 9227848  1
1997 Wiertelak EP, Roemer B, Maier SF, Watkins LR. Comparison of the effects of nucleus tractus solitarius and ventral medial medulla lesions on illness-induced and subcutaneous formalin-induced hyperalgesias. Brain Research. 748: 143-50. PMID 9067455 DOI: 10.1016/S0006-8993(96)01289-9  1
1996 Grisel JE, Watkins LR, Maier SF. Associative and non-associative mechanisms of morphine analgesic tolerance are neurochemically distinct in the rat spinal cord. Psychopharmacology. 128: 248-55. PMID 8972544 DOI: 10.1007/s002130050132  1
1996 Fleshner M, Brennan FX, Nguyen K, Watkins LR, Maier SF. RU-486 blocks differentially suppressive effect of stress on in vivo anti-KLH immunoglobulin response. The American Journal of Physiology. 271: R1344-52. PMID 8945973  1
1996 Brennan FX, Cobb CL, Silbert LH, Watkins LR, Maier SF. Peripheral beta-adrenoreceptors and stress-induced hypercholesterolemia in rats. Physiology & Behavior. 60: 1307-10. PMID 8916186 DOI: 10.1016/S0031-9384(96)00255-7  1
1996 Lockwood LL, Silbert LH, Fleshner MR, McNeal C, Watkins LR, Laudenslager ML, Rice KC, Weber RJ, Maier SF. Morphine-induced alterations in antibody levels: receptor and immune mechanisms. The Journal of Pharmacology and Experimental Therapeutics. 278: 689-96. PMID 8768720  1
1996 Brennan FX, Fleshner M, Watkins LR, Maier SF. Macrophage stimulation reduces the cholesterol levels of stressed and unstressed rats. Life Sciences. 58: 1771-6. PMID 8637401 DOI: 10.1016/0024-3205(96)00158-0  1
1995 Watkins LR, Maier SF, Goehler LE. Immune activation: the role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states. Pain. 63: 289-302. PMID 8719529 DOI: 10.1016/0304-3959(95)00186-7  1
1995 Grahn RE, Kalman BA, Brennan FX, Watkins LR, Maier SF. The elevated plus-maze is not sensitive to the effect of stressor controllability in rats. Pharmacology, Biochemistry, and Behavior. 52: 565-70. PMID 8545475 DOI: 10.1016/0091-3057(95)00141-I  1
1995 Fleshner M, Deak T, Spencer RL, Laudenslager ML, Watkins LR, Maier SF. A long-term increase in basal levels of corticosterone and a decrease in corticosteroid-binding globulin after acute stressor exposure. Endocrinology. 136: 5336-42. PMID 7588279 DOI: 10.1210/endo.136.12.7588279  1
1994 Watkins LR, Wiertelak EP, Goehler LE, Mooney-Heiberger K, Martinez J, Furness L, Smith KP, Maier SF. Neurocircuitry of illness-induced hyperalgesia. Brain Research. 639: 283-99. PMID 8205482 DOI: 10.1016/0006-8993(94)91742-6  1
1994 Wiertelak EP, Yang HY, Mooney-Heiberger K, Maier SF, Watkins LR. The nature of conditioned anti-analgesia: spinal cord opiate and anti-opiate neurochemistry. Brain Research. 634: 214-26. PMID 8131071 DOI: 10.1016/0006-8993(94)91924-0  1
1994 Wiertelak EP, Smith KP, Furness L, Mooney-Heiberger K, Mayr T, Maier SF, Watkins LR. Acute and conditioned hyperalgesic responses to illness. Pain. 56: 227-34. PMID 8008412  1
1994 Watkins LR, Wiertelak EP, Goehler LE, Smith KP, Martin D, Maier SF. Characterization of cytokine-induced hyperalgesia. Brain Research. 654: 15-26. PMID 7982088 DOI: 10.1016/0006-8993(94)91566-0  1
1994 Wiertelak EP, Furness LE, Horan R, Martinez J, Maier SF, Watkins LR. Subcutaneous formalin produces centrifugal hyperalgesia at a non-injected site via the NMDA-nitric oxide cascade. Brain Research. 649: 19-26. PMID 7953632 DOI: 10.1016/0006-8993(94)91044-8  1
1994 Wiertelak EP, Furness LE, Watkins LR, Maier SF. Illness-induced hyperalgesia is mediated by a spinal NMDA-nitric oxide cascade. Brain Research. 664: 9-16. PMID 7895051 DOI: 10.1016/0006-8993(94)91947-X  1
1994 Grisel JE, Wiertelak EP, Watkins LR, Maier SF. Route of morphine administration modulates conditioned analgesic tolerance and hyperalgesia. Pharmacology, Biochemistry, and Behavior. 49: 1029-35. PMID 7886072 DOI: 10.1016/0091-3057(94)90260-7  1
1994 Watkins LR, Wiertelak EP, Furness LE, Maier SF. Illness-induced hyperalgesia is mediated by spinal neuropeptides and excitatory amino acids. Brain Research. 664: 17-24. PMID 7534600 DOI: 10.1016/0006-8993(94)91948-8  1
1993 Watkins LR, Wiertelak EP, Maier SF. The amygdala is necessary for the expression of conditioned but not unconditioned analgesia. Behavioral Neuroscience. 107: 402-5. PMID 8484903 DOI: 10.1037/0735-7044.107.2.402  1
1993 Maier SF, Grahn RE, Kalman BA, Sutton LC, Wiertelak EP, Watkins LR. The role of the amygdala and dorsal raphe nucleus in mediating the behavioral consequences of inescapable shock. Behavioral Neuroscience. 107: 377-88. PMID 8484901 DOI: 10.1037/0735-7044.107.2.377  1
1993 Maier SF, Wiertelak EP, Martin D, Watkins LR. Interleukin-1 mediates the behavioral hyperalgesia produced by lithium chloride and endotoxin. Brain Research. 623: 321-4. PMID 8221116 DOI: 10.1016/0006-8993(93)91446-Y  1
1992 Wiertelak EP, Maier SF, Watkins LR. Cholecystokinin antianalgesia: safety cues abolish morphine analgesia. Science (New York, N.Y.). 256: 830-3. PMID 1589765  1
1992 Watkins LR, Wiertelak EP, Maier SF. Kappa opiate receptors mediate tail-shock induced antinociception at spinal levels. Brain Research. 582: 1-9. PMID 1354010 DOI: 10.1016/0006-8993(92)90310-6  1
1992 Watkins LR, Wiertelak EP, Grisel JE, Silbert LH, Maier SF. Parallel activation of multiple spinal opiate systems appears to mediate 'non-opiate' stress-induced analgesias. Brain Research. 594: 99-108. PMID 1334766 DOI: 10.1016/0006-8993(92)91033-B  1
1992 Watkins LR, Wiertelak EP, Maier SF. Delta opiate receptors mediate tail-shock induced antinociception at supraspinal levels. Brain Research. 582: 10-21. PMID 1323369 DOI: 10.1016/0006-8993(92)90311-V  1
1986 Watkins LR, Mayer DJ. Multiple endogenous opiate and non-opiate analgesia systems: evidence of their existence and clinical implications. Annals of the New York Academy of Sciences. 467: 273-99. PMID 3014973  1
1985 Ryan SM, Watkins LR, Mayer DJ, Maier SF. Spinal pain suppression mechanisms may differ for phasic and tonic pain. Brain Research. 334: 172-5. PMID 3995310 DOI: 10.1016/0006-8993(85)90582-7  1
1985 Watkins LR, Kinscheck IB, Kaufman EF, Miller J, Frenk H, Mayer DJ. Cholecystokinin antagonists selectively potentiate analgesia induced by endogenous opiates. Brain Research. 327: 181-90. PMID 3838691 DOI: 10.1016/0006-8993(85)91512-4  1
1985 Watkins LR, Kinscheck IB, Mayer DJ. Potentiation of morphine analgesia by the cholecystokinin antagonist proglumide. Brain Research. 327: 169-80. PMID 3838690 DOI: 10.1016/0006-8993(85)91511-2  1
1984 Watkins LR, Katayama Y, Kinscheck IB, Mayer DJ, Hayes RL. Muscarinic cholinergic mediation of opiate and non-opiate environmentally induced analgesias. Brain Research. 300: 231-42. PMID 6733471 DOI: 10.1016/0006-8993(84)90834-5  1
1984 Kinscheck IB, Watkins LR, Mayer DJ. Fear is not critical to classically conditioned analgesia: the effects of periaqueductal gray lesions and administration of chlordiazepoxide. Brain Research. 298: 33-44. PMID 6722557 DOI: 10.1016/0006-8993(84)91144-2  1
1984 Watkins LR, Faris PL, Komisaruk BR, Mayer DJ. Dorsolateral funiculus and intraspinal pathways mediate vaginal stimulation-induced suppression of nociceptive responding in rats. Brain Research. 294: 59-65. PMID 6697242 DOI: 10.1016/0006-8993(84)91309-X  1
1984 Watkins LR, Drugan R, Hyson RL, Moye TB, Ryan SM, Mayer DJ, Maier SF. Opiate and non-opiate analgesia induced by inescapable tail-shock: effects of dorsolateral funiculus lesions and decerebration. Brain Research. 291: 325-36. PMID 6697193 DOI: 10.1016/0006-8993(84)91265-4  1
1984 Young EG, Watkins LR, Mayer DJ. Comparison of the effects of ventral medullary lesions on systemic and microinjection morphine analgesia. Brain Research. 290: 119-29. PMID 6692127 DOI: 10.1016/0006-8993(84)90741-8  1
1984 Watkins LR, Johannessen JN, Kinscheck IB, Mayer DJ. The neurochemical basis of footshock analgesia: the role of spinal cord serotonin and norepinephrine. Brain Research. 290: 107-17. PMID 6692126 DOI: 10.1016/0006-8993(84)90740-6  1
1984 Watkins LR, Frenk H, Miller J, Mayer DJ. Effect of spinal cord lesions on convulsive activity induced by intrathecal morphine. Brain Research. 310: 337-45. PMID 6548400 DOI: 10.1016/0006-8993(84)90156-2  1
1984 Watkins LR, Kinscheck IB, Mayer DJ. Potentiation of opiate analgesia and apparent reversal of morphine tolerance by proglumide. Science (New York, N.Y.). 224: 395-6. PMID 6546809  1
1984 Frenk H, Watkins LR, Miller J, Mayer DJ. Nonspecific convulsions are induced by morphine but not D-Ala2-methionine-enkephalinamide at cortical sites. Brain Research. 299: 51-9. PMID 6326965 DOI: 10.1016/0006-8993(84)90787-X  1
1984 Watkins LR, Frenk H, Miller J, Mayer DJ. Cataleptic effects of opiates following intrathecal administration. Brain Research. 299: 43-9. PMID 6326964 DOI: 10.1016/0006-8993(84)90786-8  1
1984 Frenk H, Watkins LR, Mayer DJ. Differential behavioral effects induced by intrathecal microinjection of opiates: comparison of convulsive and cataleptic effects produced by morphine, methadone, and D-Ala2-methionine-enkephalinamide. Brain Research. 299: 31-42. PMID 6326963 DOI: 10.1016/0006-8993(84)90785-6  1
1984 Johannessen JN, Watkins LR, Mayer DJ. Non-serotonergic origins of the dorsolateral funiculus in the rat ventral medulla. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 4: 757-66. PMID 6200581  1
1983 Lewis JW, Terman GW, Watkins LR, Mayer DJ, Liebeskind JC. Opioid and non-opioid mechanisms of footshock-induced analgesia: role of the spinal dorsolateral funiculus. Brain Research. 267: 139-44. PMID 6860939 DOI: 10.1016/0006-8993(83)91047-8  1
1983 Watkins LR, Kinscheck IB, Mayer DJ. The neural basis of footshock analgesia: the effect of periaqueductal gray lesions and decerebration. Brain Research. 276: 317-24. PMID 6627012 DOI: 10.1016/0006-8993(83)90739-4  1
1983 Watkins LR, Young EG, Kinscheck IB, Mayer DJ. The neural basis of footshock analgesia: the role of specific ventral medullary nuclei. Brain Research. 276: 305-15. PMID 6627011 DOI: 10.1016/0006-8993(83)90738-2  1
1983 Faris PL, Komisaruk BR, Watkins LR, Mayer DJ. Evidence for the neuropeptide cholecystokinin as an antagonist of opiate analgesia. Science (New York, N.Y.). 219: 310-2. PMID 6294831  1
1982 Watkins LR, Cobelli DA, Mayer DJ. Opiate vs non-opiate footshock induced analgesia (FSIA): descending and intraspinal components. Brain Research. 245: 97-106. PMID 7116195 DOI: 10.1016/0006-8993(82)90342-0  1
1982 Watkins LR, Cobelli DA, Newsome HH, Mayer DJ. Footshock induced analgesia is dependent neither on pituitary nor sympathetic activation. Brain Research. 245: 81-96. PMID 7116194 DOI: 10.1016/0006-8993(82)90341-9  1
1982 Watkins LR, Cobelli DA, Mayer DJ. Classical conditioning of front paw and hind paw footshock induced analgesia (FSIA): naloxone reversibility and descending pathways. Brain Research. 243: 119-32. PMID 7116148 DOI: 10.1016/0006-8993(82)91125-8  1
1982 Watkins LR, Cobelli DA, Faris P, Aceto MD, Mayer DJ. Opiate vs non-opiate footshock-induced analgesia (FSIA): the body region shocked is a critical factor. Brain Research. 242: 299-308. PMID 7116137 DOI: 10.1016/0006-8993(82)90313-4  1
1982 Johannessen JN, Watkins LR, Carlton SM, Mayer DJ. Failure of spinal cord serotonin depletion to alter analgesia elicited from the periaqueductal gray. Brain Research. 237: 373-86. PMID 7083001 DOI: 10.1016/0006-8993(82)90449-8  1
1982 Watkins LR, Mayer DJ. Involvement of spinal opioid systems in footshock-induced analgesia: antagonism by naloxone is possible only before induction of analgesia. Brain Research. 242: 309-26. PMID 6896839 DOI: 10.1016/0006-8993(82)90314-6  1
1982 Watkins LR, Mayer DJ. Organization of endogenous opiate and nonopiate pain control systems. Science (New York, N.Y.). 216: 1185-92. PMID 6281891  1
1981 Mayer DJ, Watkins LR. Role of endorphins in endogenous pain control systems. Modern Problems of Pharmacopsychiatry. 17: 68-96. PMID 6276732  1
1981 Watkins LR, Griffin G, Leichnetz GR, Mayer DJ. Identification and somatotopic organization of nuclei projecting via the dorsolateral funiculus in rats: a retrograde tracing study using HRP slow-release gels. Brain Research. 223: 237-55. PMID 6169400 DOI: 10.1016/0006-8993(81)91139-2  1
1980 Watkins LR, Griffin G, Leichnetz GR, Mayer DJ. The somatotopic organization of the nucleus raphe magnus and surrounding brain stem structures as revealed by HRP slow-release gels. Brain Research. 181: 1-15. PMID 7350948 DOI: 10.1016/0006-8993(80)91255-X  1
Show low-probability matches.