Charles J. Heckman - Publications

Affiliations: 
University of Washington, Seattle, Seattle, WA 
 Northwestern University, Evanston, IL 
Area:
Cell Imaging & Electrophysiology, Motor Control, Movement & Rehabilitation, Systems Neuroscience

146 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Jiang MC, Birch DV, Heckman CJ, Tysseling VM. The Involvement of Ca1.3 Channels in Prolonged Root Reflexes and Its Potential as a Therapeutic Target in Spinal Cord Injury. Frontiers in Neural Circuits. 15: 642111. PMID 33867945 DOI: 10.3389/fncir.2021.642111  0.379
2021 Huh S, Heckman CJ, Manuel M. Time course of alterations in adult spinal motoneuron properties in the SOD1(G93A) mouse model of ALS. Eneuro. PMID 33632815 DOI: 10.1523/ENEURO.0378-20.2021  0.766
2020 Kim EH, Wilson JM, Thompson CK, Heckman CJ. Differences in Estimated Persistent Inward Currents Between Ankle Flexors and Extensors in Humans. Journal of Neurophysiology. PMID 32667263 DOI: 10.1152/Jn.00746.2019  0.467
2020 Wilson JM, Thompson CK, McPherson LM, Zadikoff C, Heckman CJ, MacKinnon CD. Motor Unit Discharge Variability Is Increased in Mild-To-Moderate Parkinson's Disease. Frontiers in Neurology. 11: 477. PMID 32547482 DOI: 10.3389/Fneur.2020.00477  0.394
2020 Kuo SW, Binder MD, Heckman CJ. Excessive Homeostatic Gain in Spinal Motoneurons in a Mouse Model of Amyotrophic Lateral Sclerosis. Scientific Reports. 10: 9049. PMID 32493926 DOI: 10.1038/S41598-020-65685-8  0.676
2020 Thaweerattanasinp T, Birch D, Jiang MC, Tresch MC, Bennett DJ, Heckman CJ, Tysseling VM. Bursting interneurons in the deep dorsal horn develop increased excitability and sensitivity to serotonin after chronic spinal injury. Journal of Neurophysiology. PMID 32208883 DOI: 10.1152/Jn.00701.2019  0.526
2020 Binder MD, Powers RK, Heckman CJ. Nonlinear Input-Output Functions of Motoneurons. Physiology (Bethesda, Md.). 35: 31-39. PMID 31799904 DOI: 10.1152/Physiol.00026.2019  0.779
2020 Pearcey GEP, Khurram OU, Beauchamp JA, Heckman CJ. Exploring the effects of Ia reciprocal inhibition on neuromodulatory commands in the human lower limb The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.09445  0.755
2020 Khurram OU, Negro F, Heckman CJ, Thompson CK. Estimates of Motor Neuron Excitability During Postural Sways in Lower Leg Muscles The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.06771  0.79
2020 Pearcey GE, Khurram OUH, Kim EH, Voora S, Thompson CK, Heckman CJ. An ePIC Assessment of Quadriceps Motor Unit Firing Patterns During Isometric Knee Extension: A High Density Surface Electromyography Study The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.06621  0.758
2019 Sinha N, Dewald JPA, Heckman CJ, Yang Y. Cross-Frequency Coupling in Descending Motor Pathways: Theory and Simulation. Frontiers in Systems Neuroscience. 13: 86. PMID 31992973 DOI: 10.3389/Fnsys.2019.00086  0.441
2019 Hassan AS, Thompson CK, Negro F, Cummings MQ, Powers RK, Heckman CJ, Dewald J, McPherson LM. Impact of parameter selection on estimates of motoneuron excitability using paired motor unit analysis. Journal of Neural Engineering. PMID 31801123 DOI: 10.1088/1741-2552/Ab5Eda  0.781
2019 Quinlan KA, Reedich E, Arnold WD, Puritz A, Cavarsan CF, Heckman CJ, DiDonato CJ. Hyperexcitability precedes motoneuron loss in the mouse model of spinal muscular atrophy. Journal of Neurophysiology. PMID 31365319 DOI: 10.1152/jn.00652.2018  0.422
2019 Thompson CK, Johnson MD, Negro F, Mcpherson LM, Farina D, Heckman CJ. Exogenous neuromodulation of spinal neurons induces beta-band coherence during self-sustained discharge of hindlimb motor unit populations. Journal of Applied Physiology (Bethesda, Md. : 1985). PMID 31318619 DOI: 10.1152/Japplphysiol.00110.2019  0.49
2019 Kim EH, Hassan AS, Heckman CJ. Changes in motor unit discharge patterns following strength training. The Journal of Physiology. PMID 31157914 DOI: 10.1113/Jp278137  0.344
2019 Lucas-Osma AM, Li Y, Murray KC, Lin S, Black S, Stephens MJ, Ahn AH, Heckman CJ, Fenrich KK, Fouad K, Bennett DJ. 5-HT1D receptors inhibit the monosynaptic stretch reflex by modulating C fibre activity. Journal of Neurophysiology. PMID 30625007 DOI: 10.1152/Jn.00805.2018  0.378
2019 Manuel M, Chardon M, Tysseling V, Heckman CJ. Scaling of Motor Output, From Mouse to Humans. Physiology (Bethesda, Md.). 34: 5-13. PMID 30540233 DOI: 10.1152/Physiol.00021.2018  0.75
2019 Dale E, Heckman CJ. Decision letter: The recovery of standing and locomotion after spinal cord injury does not require task-specific training Elife. DOI: 10.7554/Elife.50134.Sa1  0.305
2019 Khurram OU, Kim EH, Negro F, Heckman CJ, Thompson CK. Assessment of human motoneuron excitability during functional motor tasks The Faseb Journal. 33. DOI: 10.1096/Fasebj.2019.33.1_Supplement.538.1  0.785
2018 Franz CK, Puritz A, Jordan LA, Chow J, Ortega JA, Kiskinis E, Heckman CJ. Botulinum Toxin Conditioning Enhances Motor Axon Regeneration in Mouse and Human Preclinical Models. Neurorehabilitation and Neural Repair. 1545968318790020. PMID 30043670 DOI: 10.1177/1545968318790020  0.308
2018 McPherson JG, Ellis MD, Harden RN, Carmona C, Drogos JM, Heckman CJ, Dewald JPA. Neuromodulatory Inputs to Motoneurons Contribute to the Loss of Independent Joint Control in Chronic Moderate to Severe Hemiparetic Stroke. Frontiers in Neurology. 9: 470. PMID 29977224 DOI: 10.3389/Fneur.2018.00470  0.479
2018 Thompson CK, Negro F, Johnson MD, Holmes MR, McPherson LM, Powers RK, Farina D, Heckman CJ. Robust and accurate decoding of motoneuron behavior and prediction of the resulting force output. The Journal of Physiology. PMID 29726002 DOI: 10.1113/Jp276153  0.714
2018 McPherson JG, McPherson LM, Thompson CK, Ellis MD, Heckman CJ, Dewald JPA. Altered Neuromodulatory Drive May Contribute to Exaggerated Tonic Vibration Reflexes in Chronic Hemiparetic Stroke. Frontiers in Human Neuroscience. 12: 131. PMID 29686611 DOI: 10.3389/Fnhum.2018.00131  0.462
2018 Martinez-Silva ML, Imhoff-Manuel RD, Sharma A, Heckman CJ, Shneider NA, Roselli F, Zytnicki D, Manuel M. Hypoexcitability precedes denervation in the large fast-contracting motor units in two unrelated mouse models of ALS. Elife. 7. PMID 29580378 DOI: 10.7554/Elife.30955  0.824
2018 Ziller MJ, Ortega JA, Quinlan KA, Santos DP, Gu H, Martin EJ, Galonska C, Pop R, Maidl S, Di Pardo A, Huang M, Meltzer HY, Gnirke A, Heckman CJ, Meissner A, et al. Dissecting the Functional Consequences of De Novo DNA Methylation Dynamics in Human Motor Neuron Differentiation and Physiology. Cell Stem Cell. PMID 29551301 DOI: 10.1016/J.Stem.2018.02.012  0.316
2018 McPherson JG, Chen A, Ellis MD, Yao J, Heckman CJ, Dewald JPA. Progressive recruitment of contralesional cortico-reticulospinal pathways drives motor impairment post stroke. The Journal of Physiology. PMID 29457651 DOI: 10.1113/Jp274968  0.407
2017 Yang W, Yaggie RE, Jiang MC, Rudick CN, Done JD, Heckman CJ, Rosen JM, Schaeffer AJ, Klumpp DJ. Acyloxyacyl hydrolase modulates pelvic pain severity. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. ajpregu.00239.2017. PMID 29118019 DOI: 10.1152/Ajpregu.00239.2017  0.69
2017 Tysseling VM, Klein DA, Imhoff-Manuel R, Manuel M, Heckman CJ, Tresch MC. Constitutive activity of 5-HT2c receptors is present following incomplete spinal cord injury but is not modified after chronic SSRI or baclofen treatment. Journal of Neurophysiology. jn.00190.2017. PMID 28877964 DOI: 10.1152/Jn.00190.2017  0.751
2017 Jiang MC, Adimula A, Birch D, Heckman CJ. Hyperexcitability in synaptic and firing activities of spinal motoneurons in an adult mouse model of amyotrophic lateral sclerosis. Neuroscience. PMID 28844763 DOI: 10.1016/J.Neuroscience.2017.08.041  0.444
2017 Quinlan KA, Kajtaz E, Ciolino JD, Imhoff-Manuel RD, Tresch MC, Heckman CJ, Tysseling VM. Chronic electromyograms in treadmill running SOD1 mice reveal early changes in muscle activation. The Journal of Physiology. PMID 28543166 DOI: 10.1113/Jp274170  0.788
2017 Huh S, Siripuram R, Lee RH, Turkin VV, O'Neil D, Hamm TM, Heckman CJ, Manuel M. PICs in motoneurons do not scale with the size of the animal: A possible mechanism for faster speed of muscle contraction in smaller species. Journal of Neurophysiology. jn.00045.2017. PMID 28356469 DOI: 10.1152/Jn.00045.2017  0.75
2017 Johnson MD, Thompson CK, Tysseling VM, Powers RK, Heckman CJ. The potential for understanding the synaptic organization of human motor commands via the firing patterns of motoneurons. Journal of Neurophysiology. jn.00018.2017. PMID 28356467 DOI: 10.1152/Jn.00018.2017  0.715
2017 Johnson MD, Frigon A, Hurteau MF, Cain C, Heckman CJ. Reflex wind-up in early chronic spinal injury: plasticity of motor outputs. Journal of Neurophysiology. jn.00981.2016. PMID 28250155 DOI: 10.1152/Jn.00981.2016  0.402
2017 Kim H, Sandercock T, Heckman C. Erratum: An action potential-driven model of soleus muscle activation dynamics for locomotor-like movements (2015 J. Neural. Eng. 12 046025). Journal of Neural Engineering. PMID 28102177 DOI: 10.1088/1741-2552/Aa5A5E  0.306
2017 Powers RK, Heckman CJ. Synaptic control of the shape of the motoneuron pool input-output function. Journal of Neurophysiology. jn.00850.2016. PMID 28053245 DOI: 10.1152/Jn.00850.2016  0.718
2017 Yang W, Yaggie R, Jiang M, Rudick C, Done J, Heckman C, Schaeffer A, Klumpp D. MP85-20 ACYLOXYACYL HYDROLASE MODULATES PELVIC PAIN SEVERITY Journal of Urology. 197. DOI: 10.1016/J.Juro.2017.02.2682  0.663
2016 Thaweerattanasinp T, Heckman CJ, Tysseling VM. The firing characteristics of deep dorsal horn neurons following acute spinal transection during administration of agonists for 5-HT1B/1D and NMDA receptors. Journal of Neurophysiology. jn.00198.2016. PMID 27486104 DOI: 10.1152/Jn.00198.2016  0.417
2016 Genç B, Jara JH, Schultz MC, Manuel M, Stanford MJ, Gautam M, Klessner JL, Sekerkova G, Heller DB, Cox GA, Heckman CJ, DiDonato CJ, Özdinler PH. Absence of UCHL 1 function leads to selective motor neuropathy. Annals of Clinical and Translational Neurology. 3: 331-45. PMID 27231703 DOI: 10.1002/Acn3.298  0.749
2016 Kim H, Heckman CJ. Data for spatial characterization of AC signal propagation over primary neuron dendrites. Data in Brief. 6: 341-4. PMID 26862580 DOI: 10.1016/J.Dib.2015.12.018  0.318
2015 Kim H, Heckman CJ. The tight relationship between asymmetric signaling and locational excitability in motoneuron dendrites. Communicative & Integrative Biology. 8: e1110657. PMID 27066175 DOI: 10.1080/19420889.2015.1110657  0.353
2015 Kim H, Heckman CJ. Foundational dendritic processing that is independent of the cell type-specific structure in model primary neurons. Neuroscience Letters. PMID 26463670 DOI: 10.1016/J.Neulet.2015.10.017  0.336
2015 Kim H, Sandercock TG, Heckman CJ. An action potential-driven model of soleus muscle activation dynamics for locomotor-like movements. Journal of Neural Engineering. 12: 046025. PMID 26087477 DOI: 10.1088/1741-2560/12/4/046025  0.348
2015 Powers RK, Heckman CJ. Contribution of intrinsic motoneuron properties to discharge hysteresis and its estimation based on paired motor unit recordings: a simulation study. Journal of Neurophysiology. 114: 184-98. PMID 25904704 DOI: 10.1152/Jn.00019.2015  0.706
2015 Wilson JM, Thompson CK, Miller LC, Heckman CJ. Intrinsic excitability of human motoneurons in biceps brachii versus triceps brachii. Journal of Neurophysiology. 113: 3692-9. PMID 25787957 DOI: 10.1152/Jn.00960.2014  0.479
2014 Miller LC, Thompson CK, Negro F, Heckman CJ, Farina D, Dewald JP. High-density surface EMG decomposition allows for recording of motor unit discharge from proximal and distal flexion synergy muscles simultaneously in individuals with stroke. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2014: 5340-4. PMID 25571200 DOI: 10.1109/EMBC.2014.6944832  0.637
2014 Heckman CJ, Johnson MD. Reconfiguration of the electrical properties of motoneurons to match the diverse demands of motor behavior. Advances in Experimental Medicine and Biology. 826: 33-40. PMID 25330883 DOI: 10.1007/978-1-4939-1338-1_3  0.462
2014 Kim H, Heckman CJ. Neuromodulation impact on nonlinear firing behavior of a reduced model motoneuron with the active dendrite. Frontiers in Computational Neuroscience. 8: 110. PMID 25309410 DOI: 10.3389/Fncom.2014.00110  0.409
2014 Wei K, Glaser JI, Deng L, Thompson CK, Stevenson IH, Wang Q, Hornby TG, Heckman CJ, Kording KP. Serotonin affects movement gain control in the spinal cord. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 12690-700. PMID 25232107 DOI: 10.1523/Jneurosci.1855-14.2014  0.446
2014 Johnson MD, Heckman CJ. Gain control mechanisms in spinal motoneurons. Frontiers in Neural Circuits. 8: 81. PMID 25120435 DOI: 10.3389/Fncir.2014.00081  0.486
2014 Shoenfeld L, Westenbroek RE, Fisher E, Quinlan KA, Tysseling VM, Powers RK, Heckman CJ, Binder MD. Soma size and Cav1.3 channel expression in vulnerable and resistant motoneuron populations of the SOD1G93A mouse model of ALS. Physiological Reports. 2. PMID 25107988 DOI: 10.14814/Phy2.12113  0.762
2014 Kim H, Jones KE, Heckman CJ. Asymmetry in signal propagation between the soma and dendrites plays a key role in determining dendritic excitability in motoneurons. Plos One. 9: e95454. PMID 25083794 DOI: 10.1371/Journal.Pone.0095454  0.348
2014 Suresh AK, Hu X, Powers RK, Heckman CJ, Suresh NL, Rymer WZ. Changes in motoneuron afterhyperpolarization duration in stroke survivors. Journal of Neurophysiology. 112: 1447-56. PMID 24920018 DOI: 10.1152/Jn.01091.2012  0.744
2014 Ritter LK, Tresch MC, Heckman CJ, Manuel M, Tysseling VM. Characterization of motor units in behaving adult mice shows a wide primary range. Journal of Neurophysiology. 112: 543-51. PMID 24805075 DOI: 10.1152/Jn.00108.2014  0.772
2014 Koschnitzky JE, Quinlan KA, Lukas TJ, Kajtaz E, Kocevar EJ, Mayers WF, Siddique T, Heckman CJ. Effect of fluoxetine on disease progression in a mouse model of ALS. Journal of Neurophysiology. 111: 2164-76. PMID 24598527 DOI: 10.1152/Jn.00425.2013  0.773
2014 Mottram CJ, Heckman CJ, Powers RK, Rymer WZ, Suresh NL. Disturbances of motor unit rate modulation are prevalent in muscles of spastic-paretic stroke survivors. Journal of Neurophysiology. 111: 2017-28. PMID 24572092 DOI: 10.1152/Jn.00389.2013  0.733
2014 Delestrée N, Manuel M, Iglesias C, Elbasiouny SM, Heckman CJ, Zytnicki D. Adult spinal motoneurones are not hyperexcitable in a mouse model of inherited amyotrophic lateral sclerosis. The Journal of Physiology. 592: 1687-703. PMID 24445319 DOI: 10.1113/Jphysiol.2013.265843  0.828
2014 Kuo SW, Jiang M, Heckman C. Potential involvement of intracellular pH in a mouse model of amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 15: 151-153. PMID 24215464 DOI: 10.3109/21678421.2013.850096  0.327
2013 Johnson MD, Kajtaz E, Cain CM, Heckman CJ. Motoneuron intrinsic properties, but not their receptive fields, recover in chronic spinal injury. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 18806-13. PMID 24285887 DOI: 10.1523/Jneurosci.2609-13.2013  0.799
2013 Yasvoina MV, Genç B, Jara JH, Sheets PL, Quinlan KA, Milosevic A, Shepherd GM, Heckman CJ, Özdinler PH. eGFP expression under UCHL1 promoter genetically labels corticospinal motor neurons and a subpopulation of degeneration-resistant spinal motor neurons in an ALS mouse model. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 7890-904. PMID 23637180 DOI: 10.1523/Jneurosci.2787-12.2013  0.411
2013 Tysseling VM, Janes L, Imhoff R, Quinlan KA, Lookabaugh B, Ramalingam S, Heckman CJ, Tresch MC. Design and evaluation of a chronic EMG multichannel detection system for long-term recordings of hindlimb muscles in behaving mice. Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology. 23: 531-9. PMID 23369875 DOI: 10.1016/J.Jelekin.2012.11.014  0.397
2012 Heckman CJ, Enoka RM. Motor unit. Comprehensive Physiology. 2: 2629-82. PMID 23720261 DOI: 10.1002/cphy.c100087  0.35
2012 Suresh N, Kuo A, Heckman CJ, Rymer WZ. Using spike-triggered averaging to characterize motor unit twitch vectors in the first dorsal interosseous. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2012: 3604-7. PMID 23366707 DOI: 10.1109/EMBC.2012.6346746  0.543
2012 Manuel M, Marin M, Heckman CJ. Simultaneous intracellular recording of a lumbar motoneuron and the force produced by its motor unit in the adult mouse in vivo. Journal of Visualized Experiments : Jove. e4312. PMID 23242236 DOI: 10.3791/4312  0.799
2012 Frigon A, Hurteau MF, Johnson MD, Heckman CJ, Telonio A, Thibaudier Y. Synchronous and asynchronous electrically evoked motor activities during wind-up stimulation are differentially modulated following an acute spinal transection. Journal of Neurophysiology. 108: 3322-32. PMID 22993264 DOI: 10.1152/Jn.00683.2012  0.422
2012 Manuel M, Li Y, Elbasiouny SM, Murray K, Griener A, Heckman CJ, Bennett DJ. NMDA induces persistent inward and outward currents that cause rhythmic bursting in adult rodent motoneurons. Journal of Neurophysiology. 108: 2991-8. PMID 22972966 DOI: 10.1152/Jn.00518.2012  0.794
2012 Rudick CN, Jiang M, Yaggie RE, Pavlov VI, Done J, Heckman CJ, Whitfield C, Schaeffer AJ, Klumpp DJ. O-antigen modulates infection-induced pain states. Plos One. 7: e41273. PMID 22899994 DOI: 10.1371/Journal.Pone.0041273  0.683
2012 Frigon A, Thibaudier Y, Johnson MD, Heckman CJ, Hurteau MF. Cutaneous inputs from the back abolish locomotor-like activity and reduce spastic-like activity in the adult cat following complete spinal cord injury. Experimental Neurology. 235: 588-98. PMID 22487200 DOI: 10.1016/J.Expneurol.2012.03.013  0.419
2012 Johnson MD, Hyngstrom AS, Manuel M, Heckman CJ. Push-pull control of motor output. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 4592-9. PMID 22457505 DOI: 10.1523/Jneurosci.4709-11.2012  0.82
2012 Gogliotti RG, Quinlan KA, Barlow CB, Heier CR, Heckman CJ, Didonato CJ. Motor neuron rescue in spinal muscular atrophy mice demonstrates that sensory-motor defects are a consequence, not a cause, of motor neuron dysfunction. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 3818-29. PMID 22423102 DOI: 10.1523/Jneurosci.5775-11.2012  0.448
2012 Frigon A, Johnson MD, Heckman CJ. Differential modulation of crossed and uncrossed reflex pathways by clonidine in adult cats following complete spinal cord injury. The Journal of Physiology. 590: 973-89. PMID 22219338 DOI: 10.1113/Jphysiol.2011.222208  0.448
2012 Powers RK, Elbasiouny SM, Rymer WZ, Heckman CJ. Contribution of intrinsic properties and synaptic inputs to motoneuron discharge patterns: a simulation study. Journal of Neurophysiology. 107: 808-23. PMID 22031773 DOI: 10.1152/Jn.00510.2011  0.822
2012 Schuster JE, Fu R, Siddique T, Heckman CJ. Effect of prolonged riluzole exposure on cultured motoneurons in a mouse model of ALS. Journal of Neurophysiology. 107: 484-92. PMID 22013234 DOI: 10.1152/Jn.00714.2011  0.43
2011 Suresh NL, Wang I, Heckman CJ, Rymer WZ. Characterization of the tendon vibration reflex response in hemi-spastic stroke individuals. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2011: 2053-6. PMID 22254740 DOI: 10.1109/IEMBS.2011.6090379  0.529
2011 Manuel M, Heckman CJ. Adult mouse motor units develop almost all of their force in the subprimary range: a new all-or-none strategy for force recruitment? The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 15188-94. PMID 22016552 DOI: 10.1523/Jneurosci.2893-11.2011  0.764
2011 Frigon A, Johnson MD, Heckman CJ. Altered activation patterns by triceps surae stretch reflex pathways in acute and chronic spinal cord injury. Journal of Neurophysiology. 106: 1669-78. PMID 21734111 DOI: 10.1152/Jn.00504.2011  0.441
2011 Frigon A, Thompson CK, Johnson MD, Manuel M, Hornby TG, Heckman CJ. Extra forces evoked during electrical stimulation of the muscle or its nerve are generated and modulated by a length-dependent intrinsic property of muscle in humans and cats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 5579-88. PMID 21490198 DOI: 10.1523/Jneurosci.6641-10.2011  0.735
2011 Quinlan KA, Schuster JE, Fu R, Siddique T, Heckman CJ. Altered postnatal maturation of electrical properties in spinal motoneurons in a mouse model of amyotrophic lateral sclerosis. The Journal of Physiology. 589: 2245-60. PMID 21486770 DOI: 10.1113/Jphysiol.2010.200659  0.332
2011 Manuel M, Heckman CJ. Stronger is not always better: could a bodybuilding dietary supplement lead to ALS? Experimental Neurology. 228: 5-8. PMID 21167830 DOI: 10.1016/J.Expneurol.2010.12.007  0.696
2011 Murray KC, Stephens MJ, Ballou EW, Heckman CJ, Bennett DJ. Motoneuron excitability and muscle spasms are regulated by 5-HT2B and 5-HT2C receptor activity. Journal of Neurophysiology. 105: 731-48. PMID 20980537 DOI: 10.1152/Jn.00774.2010  0.405
2011 Binder MD, Heckman CJ, Powers RK. The Physiological Control of Motoneuron Activity Comprehensive Physiology. 3-53. DOI: 10.1002/Cphy.Cp120101  0.805
2010 Johnson MD, Heckman CJ. Interactions between focused synaptic inputs and diffuse neuromodulation in the spinal cord. Annals of the New York Academy of Sciences. 1198: 35-41. PMID 20536918 DOI: 10.1111/J.1749-6632.2010.05430.X  0.383
2010 Murray KC, Nakae A, Stephens MJ, Rank M, D'Amico J, Harvey PJ, Li X, Harris RL, Ballou EW, Anelli R, Heckman CJ, Mashimo T, Vavrek R, Sanelli L, Gorassini MA, et al. Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors. Nature Medicine. 16: 694-700. PMID 20512126 DOI: 10.1038/Nm.2160  0.516
2010 ElBasiouny SM, Schuster JE, Heckman CJ. Persistent inward currents in spinal motoneurons: important for normal function but potentially harmful after spinal cord injury and in amyotrophic lateral sclerosis. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. 121: 1669-79. PMID 20462789 DOI: 10.1016/J.Clinph.2009.12.041  0.79
2010 Elbasiouny SM, Amendola J, Durand J, Heckman CJ. Evidence from computer simulations for alterations in the membrane biophysical properties and dendritic processing of synaptic inputs in mutant superoxide dismutase-1 motoneurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 5544-58. PMID 20410108 DOI: 10.1523/Jneurosci.0434-10.2010  0.775
2009 Jiang M, Schuster JE, Fu R, Siddique T, Heckman CJ. Progressive changes in synaptic inputs to motoneurons in adult sacral spinal cord of a mouse model of amyotrophic lateral sclerosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 15031-8. PMID 19955354 DOI: 10.1523/Jneurosci.0574-09.2009  0.497
2009 Heckman CJ, Mottram C, Quinlan K, Theiss R, Schuster J. Motoneuron excitability: the importance of neuromodulatory inputs. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. 120: 2040-54. PMID 19783207 DOI: 10.1016/J.Clinph.2009.08.009  0.483
2009 Manuel M, Iglesias C, Donnet M, Leroy F, Heckman CJ, Zytnicki D. Fast kinetics, high-frequency oscillations, and subprimary firing range in adult mouse spinal motoneurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 11246-56. PMID 19741131 DOI: 10.1523/Jneurosci.3260-09.2009  0.804
2009 Mottram CJ, Suresh NL, Heckman CJ, Gorassini MA, Rymer WZ. Origins of abnormal excitability in biceps brachii motoneurons of spastic-paretic stroke survivors. Journal of Neurophysiology. 102: 2026-38. PMID 19587321 DOI: 10.1152/Jn.00151.2009  0.657
2008 McPherson JG, Ellis MD, Heckman CJ, Dewald JP. Evidence for increased activation of persistent inward currents in individuals with chronic hemiparetic stroke. Journal of Neurophysiology. 100: 3236-43. PMID 18829849 DOI: 10.1152/Jn.90563.2008  0.655
2008 Heckman CJ, Johnson M, Mottram C, Schuster J. Persistent inward currents in spinal motoneurons and their influence on human motoneuron firing patterns. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 14: 264-75. PMID 18381974 DOI: 10.1177/1073858408314986  0.453
2008 Hyngstrom A, Johnson M, Schuster J, Heckman CJ. Movement-related receptive fields of spinal motoneurones with active dendrites. The Journal of Physiology. 586: 1581-93. PMID 18238818 DOI: 10.1113/Jphysiol.2007.149146  0.741
2008 Hyngstrom AS, Johnson MD, Heckman CJ. Summation of excitatory and inhibitory synaptic inputs by motoneurons with highly active dendrites. Journal of Neurophysiology. 99: 1643-52. PMID 18234978 DOI: 10.1152/Jn.01253.2007  0.705
2008 Heckman CJ, Hyngstrom AS, Johnson MD. Active properties of motoneurone dendrites: diffuse descending neuromodulation, focused local inhibition. The Journal of Physiology. 586: 1225-31. PMID 17947305 DOI: 10.1113/Jphysiol.2007.145078  0.742
2008 Heckman CJ, Rymer WZ. Spinal mechanisms for control of muscle length and force Neuroscience in Medicine: Third Edition. 443-478. DOI: 10.1007/978-1-60327-455-5_27  0.506
2007 Hyngstrom AS, Johnson MD, Miller JF, Heckman CJ. Intrinsic electrical properties of spinal motoneurons vary with joint angle. Nature Neuroscience. 10: 363-9. PMID 17293858 DOI: 10.1038/Nn1852  0.74
2007 Anelli R, Sanelli L, Bennett DJ, Heckman CJ. Expression of L-type calcium channel alpha(1)-1.2 and alpha(1)-1.3 subunits on rat sacral motoneurons following chronic spinal cord injury. Neuroscience. 145: 751-63. PMID 17291691 DOI: 10.1016/J.Neuroscience.2006.12.043  0.362
2007 Theiss RD, Kuo JJ, Heckman CJ. Persistent inward currents in rat ventral horn neurones. The Journal of Physiology. 580: 507-22. PMID 17289788 DOI: 10.1113/Jphysiol.2006.124123  0.378
2006 Gardiner P, Dai Y, Heckman CJ. Effects of exercise training on alpha-motoneurons. Journal of Applied Physiology (Bethesda, Md. : 1985). 101: 1228-36. PMID 16778002 DOI: 10.1152/Japplphysiol.00482.2006  0.339
2006 Kuo JJ, Lee RH, Zhang L, Heckman CJ. Essential role of the persistent sodium current in spike initiation during slowly rising inputs in mouse spinal neurones. The Journal of Physiology. 574: 819-34. PMID 16728453 DOI: 10.1113/Jphysiol.2006.107094  0.425
2006 Jiang MC, Heckman CJ. In vitro sacral cord preparation and motoneuron recording from adult mice. Journal of Neuroscience Methods. 156: 31-6. PMID 16574242 DOI: 10.1016/J.Jneumeth.2006.02.002  0.317
2005 Theiss RD, Heckman CJ. Systematic variation in effects of serotonin and norepinephrine on repetitive firing properties of ventral horn neurons. Neuroscience. 134: 803-15. PMID 15987664 DOI: 10.1016/J.Neuroscience.2005.04.041  0.411
2005 Kuo JJ, Siddique T, Fu R, Heckman CJ. Increased persistent Na(+) current and its effect on excitability in motoneurones cultured from mutant SOD1 mice. The Journal of Physiology. 563: 843-54. PMID 15649979 DOI: 10.1113/Jphysiol.2004.074138  0.323
2004 Heckman CJ, Kuo JJ, Johnson MD. Synaptic integration in motoneurons with hyper-excitable dendrites. Canadian Journal of Physiology and Pharmacology. 82: 549-55. PMID 15523512 DOI: 10.1139/y04-046  0.412
2004 Hornby TG, Heckman CJ, Harvey RL, Rymer WZ. Changes in voluntary torque and electromyographic activity following oral baclofen. Muscle & Nerve. 30: 784-95. PMID 15490486 DOI: 10.1002/Mus.20176  0.604
2004 Kuo JJ, Schonewille M, Siddique T, Schults AN, Fu R, Bär PR, Anelli R, Heckman CJ, Kroese AB. Hyperexcitability of cultured spinal motoneurons from presymptomatic ALS mice. Journal of Neurophysiology. 91: 571-5. PMID 14523070 DOI: 10.1152/Jn.00665.2003  0.489
2003 Heckman CJ, Lee RH, Brownstone RM. Hyperexcitable dendrites in motoneurons and their neuromodulatory control during motor behavior. Trends in Neurosciences. 26: 688-95. PMID 14624854 DOI: 10.1016/J.Tins.2003.10.002  0.49
2003 Kuo JJ, Lee RH, Johnson MD, Heckman HM, Heckman CJ. Active dendritic integration of inhibitory synaptic inputs in vivo. Journal of Neurophysiology. 90: 3617-24. PMID 12944534 DOI: 10.1152/Jn.00521.2003  0.482
2003 Heckman CJ. Active conductances in motoneuron dendrites enhance movement capabilities. Exercise and Sport Sciences Reviews. 31: 96-101. PMID 12715974 DOI: 10.1097/00003677-200304000-00008  0.3
2003 Perreault EJ, Day SJ, Hulliger M, Heckman CJ, Sandercock TG. Summation of forces from multiple motor units in the cat soleus muscle. Journal of Neurophysiology. 89: 738-44. PMID 12574451 DOI: 10.1152/Jn.00168.2002  0.426
2003 Perreault EJ, Heckman CJ, Sandercock TG. Hill muscle model errors during movement are greatest within the physiologically relevant range of motor unit firing rates. Journal of Biomechanics. 36: 211-8. PMID 12547358 DOI: 10.1016/S0021-9290(02)00332-9  0.426
2003 Lee RH, Kuo JJ, Jiang MC, Heckman CJ. Influence of active dendritic currents on input-output processing in spinal motoneurons in vivo. Journal of Neurophysiology. 89: 27-39. PMID 12522157 DOI: 10.1152/Jn.00137.2002  0.424
2003 Heckman CJ, Johnson MD, Hyngstrom A, Perreault EJ. Mapping 3D Sensory Inputs onto Spinal Interneurons Annual International Conference of the Ieee Engineering in Medicine and Biology - Proceedings. 4: 3837-3839.  0.638
2002 Binder MD, Heckman CJ, Powers RK. Relative strengths and distributions of different sources of synaptic input to the motoneurone pool: implications for motor unit recruitment. Advances in Experimental Medicine and Biology. 508: 207-12. PMID 12171113 DOI: 10.1007/978-1-4615-0713-0_25  0.793
2001 Haftel VK, Prather JF, Heckman CJ, Cope TC. Recruitment of cat motoneurons in the absence of homonymous afferent feedback. Journal of Neurophysiology. 86: 616-28. PMID 11495937 DOI: 10.1152/Jn.2001.86.2.616  0.665
2001 Sandercock TG, Heckman CJ. Whole muscle length-tension properties vary with recruitment and rate modulation in areflexive cat soleus. Journal of Neurophysiology. 85: 1033-8. PMID 11247973 DOI: 10.1152/Jn.2001.85.3.1033  0.404
2001 Chen D, Theiss RD, Ebersole K, Miller JF, Rymer WZ, Heckman CJ. Spinal interneurons that receive input from muscle afferents are differentially modulated by dorsolateral descending systems. Journal of Neurophysiology. 85: 1005-8. PMID 11160531 DOI: 10.1152/Jn.2001.85.2.1005  0.621
2001 Lee RH, Heckman CJ. Essential role of a fast persistent inward current in action potential initiation and control of rhythmic firing. Journal of Neurophysiology. 85: 472-5. PMID 11152749 DOI: 10.1152/Jn.2001.85.1.472  0.354
2000 Lee RH, Heckman CJ. Adjustable amplification of synaptic input in the dendrites of spinal motoneurons in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 6734-40. PMID 10964980 DOI: 10.1523/Jneurosci.20-17-06734.2000  0.515
1999 Heckman CJ, Lee RH. Synaptic integration in bistable motoneurons. Progress in Brain Research. 123: 49-56. PMID 10635703 DOI: 10.1016/S0079-6123(08)62843-5  0.442
1999 Lee RH, Heckman CJ. Paradoxical effect of QX-314 on persistent inward currents and bistable behavior in spinal motoneurons in vivo. Journal of Neurophysiology. 82: 2518-27. PMID 10561423 DOI: 10.1152/Jn.1999.82.5.2518  0.405
1999 Lee RH, Heckman CJ. Enhancement of bistability in spinal motoneurons in vivo by the noradrenergic alpha1 agonist methoxamine. Journal of Neurophysiology. 81: 2164-74. PMID 10322057 DOI: 10.1152/Jn.1999.81.5.2164  0.453
1999 Heckman CJ, Lee RH. The role of voltage-sensitive dendritic conductances in generating bistable firing patterns in motoneurons. Journal of Physiology, Paris. 93: 97-100. PMID 10084713 DOI: 10.1016/S0928-4257(99)80140-5  0.415
1998 Lee RH, Heckman CJ. Bistability in spinal motoneurons in vivo: systematic variations in persistent inward currents. Journal of Neurophysiology. 80: 583-93. PMID 9705452 DOI: 10.1152/Jn.1998.80.2.583  0.367
1998 Lee RH, Heckman CJ. Bistability in spinal motoneurons in vivo: systematic variations in rhythmic firing patterns. Journal of Neurophysiology. 80: 572-82. PMID 9705451 DOI: 10.1152/Jn.1998.80.2.572  0.42
1998 Maltenfort MG, Heckman CJ, Rymer WZ. Decorrelating actions of Renshaw interneurons on the firing of spinal motoneurons within a motor nucleus: a simulation study. Journal of Neurophysiology. 80: 309-23. PMID 9658052 DOI: 10.1152/Jn.1998.80.1.309  0.623
1997 Sandercock TG, Heckman CJ. Doublet potentiation during eccentric and concentric contractions of cat soleus muscle. Journal of Applied Physiology (Bethesda, Md. : 1985). 82: 1219-28. PMID 9104859 DOI: 10.1152/Jappl.1997.82.4.1219  0.348
1997 Sandercock TG, Heckman CJ. Force from cat soleus muscle during imposed locomotor-like movements: experimental data versus Hill-type model predictions. Journal of Neurophysiology. 77: 1538-52. PMID 9084618 DOI: 10.1152/Jn.1997.77.3.1538  0.37
1996 Boskov D, Heckman CJ. Motor unit recruitment patterns during reflex compensation of muscle yield investigated by computer simulations. Biological Cybernetics. 75: 211-7. PMID 8900036 DOI: 10.1007/S004220050288  0.439
1996 Lee RH, Heckman CJ. Influence of voltage-sensitive dendritic conductances on bistable firing and effective synaptic current in cat spinal motoneurons in vivo. Journal of Neurophysiology. 76: 2107-10. PMID 8890322 DOI: 10.1152/Jn.1996.76.3.2107  0.445
1996 Heckman CJ, Sandercock TG. From motor unit to whole muscle properties during locomotor movements. Exercise and Sport Sciences Reviews. 24: 109-33. PMID 8744248 DOI: 10.1249/00003677-199600240-00006  0.334
1996 Miller JF, Paul KD, Lee RH, Rymer WZ, Heckman CJ. Restoration of extensor excitability in the acute spinal cat by the 5-HT2 agonist DOI. Journal of Neurophysiology. 75: 620-8. PMID 8714639 DOI: 10.1152/Jn.1996.75.2.620  0.544
1995 Miller JF, Paul KD, Jiang B, Rymer WZ, Heckman CJ. Effect of reversible dorsal cold block on the persistence of inhibition generated by spinal reflexes. Experimental Brain Research. 107: 205-14. PMID 8773240 DOI: 10.1007/Bf00230042  0.527
1995 Miller JF, Paul KD, Rymer WZ, Heckman CJ. 5-HT1B/1D agonist CGS-12066B attenuates clasp knife reflex in the cat. Journal of Neurophysiology. 74: 453-6. PMID 7472346 DOI: 10.1152/Jn.1995.74.1.453  0.527
1994 Heckman CJ, Miller JF, Munson M, Paul KD, Rymer WZ. Reduction in postsynaptic inhibition during maintained electrical stimulation of different nerves in the cat hindlimb. Journal of Neurophysiology. 71: 2281-93. PMID 7931517 DOI: 10.1152/Jn.1994.71.6.2281  0.517
1994 Heckman CJ. Computer simulations of the effects of different synaptic input systems on the steady-state input-output structure of the motoneuron pool. Journal of Neurophysiology. 71: 1727-39. PMID 7914915 DOI: 10.1152/Jn.1994.71.5.1727  0.469
1994 Heckman CJ. Alterations in synaptic input to motoneurons during partial spinal cord injury. Medicine and Science in Sports and Exercise. 26: 1480-90. PMID 7869883 DOI: 10.1249/00005768-199412000-00012  0.472
1993 Heckman CJ, Binder MD. Computer simulations of motoneuron firing rate modulation. Journal of Neurophysiology. 69: 1005-8. PMID 8492143 DOI: 10.1152/Jn.1993.69.4.1005  0.698
1993 Heckman CJ, Binder MD. Computer simulations of the effects of different synaptic input systems on motor unit recruitment. Journal of Neurophysiology. 70: 1827-40. PMID 8294958 DOI: 10.1152/Jn.1993.70.5.1827  0.684
1993 Binder MD, Heckman CJ, Powers RK. How different afferent inputs control motoneuron discharge and the output of the motoneuron pool. Current Opinion in Neurobiology. 3: 1028-34. PMID 8124071 DOI: 10.1016/0959-4388(93)90177-Z  0.791
1992 Heckman CJ, Weytjens JL, Loeb GE. Effect of velocity and mechanical history on the forces of motor units in the cat medial gastrocnemius muscle. Journal of Neurophysiology. 68: 1503-15. PMID 1479427 DOI: 10.1152/Jn.1992.68.5.1503  0.44
1992 Heckman CJ, Miller JF, Munson M, Rymer WZ. Differences between steady-state and transient post-synaptic potentials elicited by stimulation of the sural nerve. Experimental Brain Research. 91: 167-70. PMID 1301370 DOI: 10.1007/Bf00230025  0.558
1991 Heckman CJ, Binder MD. Computer simulation of the steady-state input-output function of the cat medial gastrocnemius motoneuron pool. Journal of Neurophysiology. 65: 952-67. PMID 2051212 DOI: 10.1152/Jn.1991.65.4.952  0.71
1991 Heckman CJ, Binder MD. Analysis of Ia-inhibitory synaptic input to cat spinal motoneurons evoked by vibration of antagonist muscles. Journal of Neurophysiology. 66: 1888-93. PMID 1812223 DOI: 10.1152/Jn.1991.66.6.1888  0.698
1988 Heckman CJ, Binder MD. Analysis of effective synaptic currents generated by homonymous Ia afferent fibers in motoneurons of the cat. Journal of Neurophysiology. 60: 1946-66. PMID 3236057 DOI: 10.1152/Jn.1988.60.6.1946  0.684
1986 Hayward LF, Nielsen RP, Heckman CJ, Hutton RS. Tendon vibration-induced inhibition of human and cat triceps surae group I reflexes: evidence of selective Ib afferent fiber activation. Experimental Neurology. 94: 333-47. PMID 3770124 DOI: 10.1016/0014-4886(86)90107-X  0.346
1984 Heckman CJ, Condon SM, Hutton RS, Enoka RM. Can Ib axons be selectively activated by electrical stimuli in human subjects? Experimental Neurology. 86: 576-82. PMID 6499994 DOI: 10.1016/0014-4886(84)90090-6  0.328
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