Hariharan Saminathan, Ph.D. - Related publications

Affiliations: 
2011 Interdisciplinary Graduate Studies Iowa State University, Ames, IA, United States 
Area:
Neuroscience, Toxicology
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Helton LG, Soliman A, von Zweydorf F, Kentros M, Manschwetus JT, Hall S, Gilsbach B, Ho FY, Athanasopoulos PS, Singh RK, LeClair TJ, Versées W, Raimondi F, Herberg FW, Gloeckner CJ, et al. Allosteric Inhibition of Parkinson's-Linked LRRK2 by Constrained Peptides. Acs Chemical Biology. PMID 34496561 DOI: 10.1021/acschembio.1c00487   
2021 Ogata J, Hirao K, Nishioka K, Hayashida A, Li Y, Yoshino H, Shimizu S, Hattori N, Imai Y. A Novel LRRK2 Variant p.G2294R in the WD40 Domain Identified in Familial Parkinson's Disease Affects LRRK2 Protein Levels. International Journal of Molecular Sciences. 22. PMID 33918221 DOI: 10.3390/ijms22073708   
2021 Gros P, Wang X, Guan J, Lang AE, Austin PC, Welk B, Visanji NP, Marras C. Exposure to Phosphoglycerate Kinase 1 Activators and Incidence of Parkinson's Disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 34241922 DOI: 10.1002/mds.28712   
2021 Madhi I, Kim JH, Shin JE, Kim Y. Ginsenoside Re exhibits neuroprotective effects by inhibiting neuroinflammation via CAMK/MAPK/NF‑κB signaling in microglia. Molecular Medicine Reports. 24. PMID 34368872 DOI: 10.3892/mmr.2021.12337   
2021 Albanese F, Mercatelli D, Finetti L, Lamonaca G, Pizzi S, Shimshek DR, Bernacchia G, Morari M. Constitutive silencing of LRRK2 kinase activity leads to early glucocerebrosidase deregulation and late impairment of autophagy in vivo. Neurobiology of Disease. 159: 105487. PMID 34419621 DOI: 10.1016/j.nbd.2021.105487   
2021 Drysch M, Schmidt SV, Becerikli M, Reinkemeier F, Dittfeld S, Wagner JM, Dadras M, Sogorski A, von Glinski M, Lehnhardt M, Behr B, Wallner C. Myostatin Deficiency Protects C2C12 Cells from Oxidative Stress by Inhibiting Intrinsic Activation of Apoptosis. Cells. 10. PMID 34359850 DOI: 10.3390/cells10071680   
2021 Liu Q, Bautista-Gomez J, Higgins DA, Yu J, Xiong Y. Dysregulation of the AP2M1 phosphorylation cycle by LRRK2 impairs endocytosis and leads to dopaminergic neurodegeneration. Science Signaling. 14. PMID 34315807 DOI: 10.1126/scisignal.abg3555   
2021 Liu Q, Bautista-Gomez J, Higgins DA, Yu J, Xiong Y. Dysregulation of the AP2M1 phosphorylation cycle by LRRK2 impairs endocytosis and leads to dopaminergic neurodegeneration. Science Signaling. 14. PMID 34315807 DOI: 10.1126/scisignal.abg3555   
2021 Singh F, Prescott AR, Rosewell P, Ball G, Reith AD, Ganley IG. Pharmacological rescue of impaired mitophagy in Parkinson's disease-related LRRK2 G2019S knock-in mice. Elife. 10. PMID 34340748 DOI: 10.7554/eLife.67604   
2021 Hou XO, Tu HY, Qian HC, Li Q, Yang YP, Xu GQ, Wang F, Liu CF, Wang YL, Hu LF. AMPK S-sulfuration contributes to HS donors-induced AMPK phosphorylation and autophagy activation in dopaminergic cells. Neurochemistry International. 105187. PMID 34534609 DOI: 10.1016/j.neuint.2021.105187   
2021 Jadaun KS, Sharma A, Siddiqui EM, Mehan S. Targeting abnormal PI3K/AKT/mTOR signaling in intracerebral hemorrhage: A systematic review on potential drug targets and influences of signaling modulators on other neurological disorders. Current Reviews in Clinical and Experimental Pharmacology. PMID 34455956 DOI: 10.2174/1574884716666210726110021   
2021 Chen J, Ye C, Wan C, Li G, Peng L, Peng Y, Fang R. The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases. International Journal of Molecular Sciences. 22. PMID 34502556 DOI: 10.3390/ijms22179640   
2021 Efferth T, Oesch F. The immunosuppressive activity of artemisinin-type drugs towards inflammatory and autoimmune diseases. Medicinal Research Reviews. PMID 34288018 DOI: 10.1002/med.21842   
2021 Sanchez-Garrido J, Shenoy AR. Regulation and repurposing of nutrient sensing and autophagy in innate immunity. Autophagy. 17: 1571-1591. PMID 32627660 DOI: 10.1080/15548627.2020.1783119   
2021 Lien CF, Chen SJ, Tsai MC, Lin CS. Potential Role of Protein Kinase C in the Pathophysiology of Diabetes-Associated Atherosclerosis. Frontiers in Pharmacology. 12: 716332. PMID 34276388 DOI: 10.3389/fphar.2021.716332   
2021 Lien CF, Chen SJ, Tsai MC, Lin CS. Potential Role of Protein Kinase C in the Pathophysiology of Diabetes-Associated Atherosclerosis. Frontiers in Pharmacology. 12: 716332. PMID 34276388 DOI: 10.3389/fphar.2021.716332   
2021 Xu Y, Ji Y, Li X, Ding J, Chen L, Huang Y, Wei W. URI1 suppresses irradiation-induced reactive oxygen species (ROS) by activating autophagy in hepatocellular carcinoma cells. International Journal of Biological Sciences. 17: 3091-3103. PMID 34421352 DOI: 10.7150/ijbs.55689   
2021 Hassoun R, Budde H, Zhazykbayeva S, Herwig M, Sieme M, Delalat S, Mostafi N, Gömöri K, Tangos M, Jarkas M, Pabel S, Bruckmüller S, Skrygan M, Lódi M, Jaquet K, et al. Stress activated signalling impaired protein quality control pathways in human hypertrophic cardiomyopathy. International Journal of Cardiology. PMID 34517018 DOI: 10.1016/j.ijcard.2021.09.009   
2021 Ye Y, Cai Y, Xia E, Shi K, Jin Z, Chen H, Xia F, Xia Y, Papadimos TJ, Xu X, Liu L, Wang Q. Apelin-13 Reverses Bupivacaine-Induced Cardiotoxicity via the Adenosine Monophosphate-Activated Protein Kinase Pathway. Anesthesia and Analgesia. 133: 1048-1059. PMID 34524989 DOI: 10.1213/ANE.0000000000005692   
2021 Shu ST, Li WF, Smithgall TE. Visualization of Host Cell Kinase Activation by Viral Proteins Using GFP Fluorescence Complementation and Immunofluorescence Microscopy. Bio-Protocol. 11: e4068. PMID 34327265 DOI: 10.21769/BioProtoc.4068   
2021 Nuro-Gyina PK, Tang N, Guo H, Yan C, Zeng Q, Waldschmidt TJ, Zhang J. HECT E3 Ubiquitin Ligase Nedd4 Is Required for Antifungal Innate Immunity. Journal of Immunology (Baltimore, Md. : 1950). PMID 34282001 DOI: 10.4049/jimmunol.2100083   
2021 Nuro-Gyina PK, Tang N, Guo H, Yan C, Zeng Q, Waldschmidt TJ, Zhang J. HECT E3 Ubiquitin Ligase Nedd4 Is Required for Antifungal Innate Immunity. Journal of Immunology (Baltimore, Md. : 1950). PMID 34282001 DOI: 10.4049/jimmunol.2100083   
2021 Huang Y, Li X, Liu Y, Gong Q, Tian J, Jiang H. LPS-induced autophagy in human dental pulp cells is associated with p38. Journal of Molecular Histology. PMID 34309809 DOI: 10.1007/s10735-021-10004-2   
2021 Chan TY, Egbert CM, Maxson JE, Siddiqui A, Larsen LJ, Kohler K, Balasooriya ER, Pennington KL, Tsang TM, Frey M, Soderblom EJ, Geng H, Müschen M, Forostyan TV, Free S, et al. TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth. Nature Communications. 12: 5337. PMID 34504101 DOI: 10.1038/s41467-021-25622-3   
2021 Preynat-Seauve O, Nguyen EB, Westermaier Y, Héritier M, Tardy S, Cambet Y, Feyeux M, Caillon A, Scapozza L, Krause KH. Novel Mechanism for an Old Drug: Phenazopyridine is a Kinase Inhibitor Affecting Autophagy and Cellular Differentiation. Frontiers in Pharmacology. 12: 664608. PMID 34421588 DOI: 10.3389/fphar.2021.664608   
2021 Maldonado E, Rojas DA, Urbina F, Solari A. T. cruzi DNA polymerase beta (Tcpolβ) is phosphorylated in vitro by CK1, CK2 and TcAUK1 leading to the potentiation of its DNA synthesis activity. Plos Neglected Tropical Diseases. 15: e0009588. PMID 34260580 DOI: 10.1371/journal.pntd.0009588   
2021 Tan S, Gong X, Liu H, Yao X. Virtual Screening and Biological Activity Evaluation of New Potent Inhibitors Targeting LRRK2 Kinase Domain. Acs Chemical Neuroscience. PMID 34387082 DOI: 10.1021/acschemneuro.1c00399   
2021 Herbst S, Lewis PA. From structure to ætiology: a new window on the biology of leucine-rich repeat kinase 2 and Parkinson's disease. The Biochemical Journal. 478: 2945-2951. PMID 34328508 DOI: 10.1042/BCJ20210383   
2021 Wang H, Liu M, Ye Z, Zhou C, Bi H, Wang L, Zhang C, Fu H, Shen Y, Yang J, Hu Y, Chen G. Akt regulates Sox10 expression to control oligodendrocyte differentiation via phosphorylating FoxO1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 34385359 DOI: 10.1523/JNEUROSCI.2432-20.2021   
2021 Lim SR, Kim DW, Sung J, Kim TH, Choi CH, Lee SJ. Astaxanthin Inhibits Autophagic Cell Death Induced by Bisphenol A in Human Dermal Fibroblasts. Antioxidants (Basel, Switzerland). 10. PMID 34439521 DOI: 10.3390/antiox10081273   
2021 He H, Yang W, Huang Y, Zhang X, Peng Y, Yang Z. Successful management of lung adenocarcinoma with ALK/EGFR co-alterations and PD-L1 over-expression by bevacizumab combined with chemotherapy. Angiogenesis. PMID 34342748 DOI: 10.1007/s10456-021-09811-8   
2021 Weeks AM. Kinases leave their mark on caspase substrates. The Biochemical Journal. 478: 3179-3184. PMID 34492095 DOI: 10.1042/BCJ20210399   
2021 Horvath C, Young M, Jarabicova I, Kindernay L, Ferenczyova K, Ravingerova T, Lewis M, Suleiman MS, Adameova A. Inhibition of Cardiac RIP3 Mitigates Early Reperfusion Injury and Calcium-Induced Mitochondrial Swelling without Altering Necroptotic Signalling. International Journal of Molecular Sciences. 22. PMID 34360749 DOI: 10.3390/ijms22157983   
2021 Ali S, Khan MR, Iqbal J, Batool R, Naz I, Yaseen T, Abbasi BA, Nasir JA, El-Serehy HA. Chemical composition and pharmacological bio-efficacy of (Decne) Rehder for anticancer activity. Saudi Journal of Biological Sciences. 28: 4969-4986. PMID 34466072 DOI: 10.1016/j.sjbs.2021.07.072   
2021 Cavender MA, O'Donoghue M, Abbate A, Aylward P, Fox KAA, Glaser RX, Park JG, Lopez-Sendon J, Steg PG, Sabatine MS, Morrow DA. Inhibition of p38 MAP Kinase in Patients with ST-Elevation Myocardial Infarction - Findings from the LATITUDE TIMI 60 Trial. American Heart Journal. PMID 34508693 DOI: 10.1016/j.ahj.2021.08.022   
2021 Yu Z, Jiang N, Su W, Zhuo Y. Necroptosis: A Novel Pathway in Neuroinflammation. Frontiers in Pharmacology. 12: 701564. PMID 34322024 DOI: 10.3389/fphar.2021.701564   
2021 Karia P, Yoshioka K, Moeder W. Multiple phosphorylation events of the mitochondrial membrane protein TTM1 regulate cell death during senescence. The Plant Journal : For Cell and Molecular Biology. PMID 34409658 DOI: 10.1111/tpj.15470   
2021 Carrasco-Navarro U, Aguirre J. HO Induces Major Phosphorylation Changes in Critical Regulators of Signal Transduction, Gene Expression, Metabolism and Developmental Networks in . Journal of Fungi (Basel, Switzerland). 7. PMID 34436163 DOI: 10.3390/jof7080624   
2021 Caliz AD, Yoo HJ, Vertii A, Dolan AC, Tournier C, Davis RJ, Keaney JF, Kant S. Mitogen Kinase Kinase (MKK7) Controls Cytokine Production In Vitro and In Vivo in Mice. International Journal of Molecular Sciences. 22. PMID 34502275 DOI: 10.3390/ijms22179364   
2021 Ahmadu AA, Delehouzé C, Haruna A, Mustapha L, Lawal BA, Udobre A, Baratte B, Triscornia C, Autret A, Robert T, Bulinski JC, Rousselot M, Simoes Eugénio M, Dimanche-Boitrel MT, Petzer JP, et al. Betulin, a Newly Characterized Compound in Bark, Is a Multi-Target Protein Kinase Inhibitor. Molecules (Basel, Switzerland). 26. PMID 34361750 DOI: 10.3390/molecules26154599   
2021 El-Sayed N, Mostafa YM, AboGresha NM, Ahmed AAM, Mahmoud IZ, El-Sayed NM. Dapagliflozin attenuates diabetic cardiomyopathy through erythropoietin up-regulation of AKT/JAK/MAPK pathways in streptozotocin-induced diabetic rats. Chemico-Biological Interactions. 347: 109617. PMID 34391751 DOI: 10.1016/j.cbi.2021.109617   
2021 Takei GL, Tourzani DA, Paudel B, Visconti PE. Activation of cAMP-dependent phosphorylation pathways is independent of ROS production during mouse sperm capacitation. Molecular Reproduction and Development. PMID 34318548 DOI: 10.1002/mrd.23524   
2021 Jin YJ, Chennupati R, Li R, Liang G, Wang S, Iring A, Graumann J, Wettschureck N, Offermanns S. Protein kinase N2 mediates flow-induced eNOS activation and vascular tone regulation. The Journal of Clinical Investigation. PMID 34499618 DOI: 10.1172/JCI145734   
2021 Gong W, Liu P, Zheng T, Wu X, Zhao Y, Ren J. The ubiquitous role of spleen tyrosine kinase (Syk) in gut diseases: From mucosal immunity to targeted therapy. International Reviews of Immunology. 1-12. PMID 34355656 DOI: 10.1080/08830185.2021.1962860   
2021 Kocak M, Ezazi Erdi S, Jorba G, Maestro I, Farrés J, Kirkin V, Martinez A, Pless O. Targeting autophagy in disease: established and new strategies. Autophagy. 1-23. PMID 34241570 DOI: 10.1080/15548627.2021.1936359   
2021 Kocak M, Ezazi Erdi S, Jorba G, Maestro I, Farrés J, Kirkin V, Martinez A, Pless O. Targeting autophagy in disease: established and new strategies. Autophagy. 1-23. PMID 34241570 DOI: 10.1080/15548627.2021.1936359   
2021 Chaisit S, Jianmongkol S. Apoptosis Inducing Activity of Rhinacanthin-C in Doxorubicin-Resistant Breast Cancer MCF-7 Cells. Biological & Pharmaceutical Bulletin. 44: 1239-1246. PMID 34471052 DOI: 10.1248/bpb.b21-00015   
2021 Arribas-Blázquez M, Piniella D, Olivos-Oré LA, Bartolomé-Martín D, Leite C, Giménez C, Artalejo AR, Zafra F. Regulation of the voltage-dependent sodium channel Na1.1 by AKT1. Neuropharmacology. 197: 108745. PMID 34375627 DOI: 10.1016/j.neuropharm.2021.108745   
2021 Li T, Zhang J, Wang PJ, Zhang ZW, Huang JQ. Selenoproteins Protect Against Avian Liver Necrosis by Metabolizing Peroxides and Regulating Receptor Interacting Serine Threonine Kinase 1/Receptor Interacting Serine Threonine Kinase 3/Mixed Lineage Kinase Domain-Like and Mitogen-Activated Protein Kinase Signaling. Frontiers in Physiology. 12: 696256. PMID 34456747 DOI: 10.3389/fphys.2021.696256   
2021 Bie N, Feng X, Li C, Meng M, Wang C. The Protective Effect of Docosahexaenoic Acid on PC12 Cells in Oxidative Stress Induced by HO through the TrkB-Erk1/2-CREB Pathway. Acs Chemical Neuroscience. PMID 34428890 DOI: 10.1021/acschemneuro.1c00421