Darren Moore, Ph.D - Publications

Babraham Institute Cambridge University, Cambridge U.K, Cambridge, England, United Kingdom 

48 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Nucifora FC, Nucifora LG, Ng CH, Arbez N, Guo Y, Roby E, Shani V, Engelender S, Wei D, Wang XF, Li T, Moore DJ, Pletnikova O, Troncoso JC, Sawa A, et al. Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1. Nature Communications. 7: 11792. PMID 27273569 DOI: 10.1038/ncomms11792  0.4
2016 Moore DJ. Limited diversity sparks inflammation at the mucosal border Science Translational Medicine. 8. DOI: 10.1126/scitranslmed.aaf6416  0.56
2015 Stocks BT, Wilhelm AJ, Wilson CS, Marshall AF, Putnam NE, Major AS, Moore DJ. Lupus-Prone Mice Resist Immune Regulation and Transplant Tolerance Induction. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. PMID 26372909 DOI: 10.1111/ajt.13449  0.56
2015 Tsika E, Nguyen AP, Dusonchet J, Colin P, Schneider BL, Moore DJ. Adenoviral-mediated expression of G2019S LRRK2 induces striatal pathology in a kinase-dependent manner in a rat model of Parkinson's disease. Neurobiology of Disease. 77: 49-61. PMID 25731749 DOI: 10.1016/j.nbd.2015.02.019  0.4
2015 Daniel G, Moore DJ. Modeling LRRK2 Pathobiology in Parkinson's Disease: From Yeast to Rodents. Current Topics in Behavioral Neurosciences. 22: 331-68. PMID 24850078 DOI: 10.1007/7854_2014_311  0.4
2014 Daniel G, Musso A, Tsika E, Fiser A, Glauser L, Pletnikova O, Schneider BL, Moore DJ. α-Synuclein-induced dopaminergic neurodegeneration in a rat model of Parkinson's disease occurs independent of ATP13A2 (PARK9). Neurobiology of Disease. 73: 229-243. PMID 25461191 DOI: 10.1016/j.nbd.2014.10.007  0.4
2014 Tsika E, Kannan M, Foo CS, Dikeman D, Glauser L, Gellhaar S, Galter D, Knott GW, Dawson TM, Dawson VL, Moore DJ. Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration. Neurobiology of Disease. 71: 345-58. PMID 25174890 DOI: 10.1016/j.nbd.2014.08.027  0.4
2014 Dusonchet J, Li H, Guillily M, Liu M, Stafa K, Derada Troletti C, Boon JY, Saha S, Glauser L, Mamais A, Citro A, Youmans KL, Liu L, Schneider BL, Aebischer P, ... ... Moore DJ, et al. A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity. Human Molecular Genetics. 23: 4887-905. PMID 24794857 DOI: 10.1093/hmg/ddu202  0.4
2014 Tsika E, Glauser L, Moser R, Fiser A, Daniel G, Sheerin UM, Lees A, Troncoso JC, Lewis PA, Bandopadhyay R, Schneider BL, Moore DJ. Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration. Human Molecular Genetics. 23: 4621-38. PMID 24740878 DOI: 10.1093/hmg/ddu178  0.4
2014 Stafa K, Tsika E, Moser R, Musso A, Glauser L, Jones A, Biskup S, Xiong Y, Bandopadhyay R, Dawson VL, Dawson TM, Moore DJ. Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily. Human Molecular Genetics. 23: 2055-77. PMID 24282027 DOI: 10.1093/hmg/ddt600  0.4
2013 Tsika E, Moore DJ. Contribution of GTPase activity to LRRK2-associated Parkinson disease. Small Gtpases. 4: 164-70. PMID 24025585 DOI: 10.4161/sgtp.25130  0.4
2013 Fraser KB, Moehle MS, Daher JP, Webber PJ, Williams JY, Stewart CA, Yacoubian TA, Cowell RM, Dokland T, Ye T, Chen D, Siegal GP, Galemmo RA, Tsika E, Moore DJ, et al. LRRK2 secretion in exosomes is regulated by 14-3-3. Human Molecular Genetics. 22: 4988-5000. PMID 23886663 DOI: 10.1093/hmg/ddt346  0.4
2013 Mamais A, Raja M, Manzoni C, Dihanich S, Lees A, Moore D, Lewis PA, Bandopadhyay R. Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases. Neurobiology of Disease. 58: 183-90. PMID 23747310 DOI: 10.1016/j.nbd.2013.05.017  0.4
2012 Tsika E, Moore DJ. Mechanisms of LRRK2-mediated neurodegeneration. Current Neurology and Neuroscience Reports. 12: 251-60. PMID 22441981 DOI: 10.1007/s11910-012-0265-8  0.4
2012 Daher JP, Pletnikova O, Biskup S, Musso A, Gellhaar S, Galter D, Troncoso JC, Lee MK, Dawson TM, Dawson VL, Moore DJ. Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2. Human Molecular Genetics. 21: 2420-31. PMID 22357653 DOI: 10.1093/hmg/dds057  0.4
2012 Fauvet B, Mbefo MK, Fares MB, Desobry C, Michael S, Ardah MT, Tsika E, Coune P, Prudent M, Lion N, Eliezer D, Moore DJ, Schneider B, Aebischer P, El-Agnaf OM, et al. α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer. The Journal of Biological Chemistry. 287: 15345-64. PMID 22315227 DOI: 10.1074/jbc.M111.318949  0.4
2011 Ramonet D, Daher JP, Lin BM, Stafa K, Kim J, Banerjee R, Westerlund M, Pletnikova O, Glauser L, Yang L, Liu Y, Swing DA, Beal MF, Troncoso JC, McCaffery JM, ... ... Moore DJ, et al. Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2. Plos One. 6: e18568. PMID 21494637 DOI: 10.1371/journal.pone.0018568  0.4
2011 Dusonchet J, Kochubey O, Stafa K, Young SM, Zufferey R, Moore DJ, Schneider BL, Aebischer P. A rat model of progressive nigral neurodegeneration induced by the Parkinson's disease-associated G2019S mutation in LRRK2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 907-12. PMID 21248115 DOI: 10.1523/JNEUROSCI.5092-10.2011  0.4
2010 Li X, Moore DJ, Xiong Y, Dawson TM, Dawson VL. Reevaluation of phosphorylation sites in the Parkinson disease-associated leucine-rich repeat kinase 2. The Journal of Biological Chemistry. 285: 29569-76. PMID 20595391 DOI: 10.1074/jbc.M110.127639  0.4
2010 Xiong Y, Coombes CE, Kilaru A, Li X, Gitler AD, Bowers WJ, Dawson VL, Dawson TM, Moore DJ. GTPase activity plays a key role in the pathobiology of LRRK2. Plos Genetics. 6: e1000902. PMID 20386743 DOI: 10.1371/journal.pgen.1000902  0.4
2010 Vives-Bauza C, Zhou C, Huang Y, Cui M, de Vries RL, Kim J, May J, Tocilescu MA, Liu W, Ko HS, Magrané J, Moore DJ, Dawson VL, Grailhe R, Dawson TM, et al. PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proceedings of the National Academy of Sciences of the United States of America. 107: 378-83. PMID 19966284 DOI: 10.1073/pnas.0911187107  0.4
2009 Higashi S, Moore DJ, Yamamoto R, Minegishi M, Sato K, Togo T, Katsuse O, Uchikado H, Furukawa Y, Hino H, Kosaka K, Emson PC, Wada K, Dawson VL, Dawson TM, et al. Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease. Journal of Neuropathology and Experimental Neurology. 68: 994-1005. PMID 19680143 DOI: 10.1097/NEN.0b013e3181b44ed8  0.4
2009 Daher JP, Ying M, Banerjee R, McDonald RS, Hahn MD, Yang L, Flint Beal M, Thomas B, Dawson VL, Dawson TM, Moore DJ. Conditional transgenic mice expressing C-terminally truncated human alpha-synuclein (alphaSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons. Molecular Neurodegeneration. 4: 34. PMID 19630976 DOI: 10.1186/1750-1326-4-34  0.4
2009 Dawson TM, Moore DJ, West AB. Revelations and revolutions in the understanding of Parkinson's disease. Biochimica Et Biophysica Acta. 1792: 585-6. PMID 19539178 DOI: 10.1016/j.bbadis.2009.06.001  0.4
2009 Ko HS, Bailey R, Smith WW, Liu Z, Shin JH, Lee YI, Zhang YJ, Jiang H, Ross CA, Moore DJ, Patterson C, Petrucelli L, Dawson TM, Dawson VL. CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity. Proceedings of the National Academy of Sciences of the United States of America. 106: 2897-902. PMID 19196961 DOI: 10.1073/pnas.0810123106  0.4
2008 Moore DJ. The biology and pathobiology of LRRK2: implications for Parkinson's disease. Parkinsonism & Related Disorders. 14: S92-8. PMID 18602856 DOI: 10.1016/j.parkreldis.2008.04.010  0.4
2008 Moore DJ, Dawson TM. Value of genetic models in understanding the cause and mechanisms of Parkinson's disease. Current Neurology and Neuroscience Reports. 8: 288-96. PMID 18590612 DOI: 10.1007/s11910-008-0045-7  0.4
2008 Wang L, Xie C, Greggio E, Parisiadou L, Shim H, Sun L, Chandran J, Lin X, Lai C, Yang WJ, Moore DJ, Dawson TM, Dawson VL, Chiosis G, Cookson MR, et al. The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 3384-91. PMID 18367605 DOI: 10.1523/JNEUROSCI.0185-08.2008  0.4
2008 Moore DJ, West AB, Dikeman DA, Dawson VL, Dawson TM. Parkin mediates the degradation-independent ubiquitination of Hsp70. Journal of Neurochemistry. 105: 1806-19. PMID 18248624 DOI: 10.1111/j.1471-4159.2008.05261.x  0.4
2007 Biskup S, Moore DJ, Rea A, Lorenz-Deperieux B, Coombes CE, Dawson VL, Dawson TM, West AB. Dynamic and redundant regulation of LRRK2 and LRRK1 expression. Bmc Neuroscience. 8: 102. PMID 18045479 DOI: 10.1186/1471-2202-8-102  0.4
2007 Higashi S, Biskup S, West AB, Trinkaus D, Dawson VL, Faull RL, Waldvogel HJ, Arai H, Dawson TM, Moore DJ, Emson PC. Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain. Brain Research. 1155: 208-19. PMID 17512502 DOI: 10.1016/j.brainres.2007.04.034  0.4
2007 West AB, Moore DJ, Choi C, Andrabi SA, Li X, Dikeman D, Biskup S, Zhang Z, Lim KL, Dawson VL, Dawson TM. Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity. Human Molecular Genetics. 16: 223-32. PMID 17200152 DOI: 10.1093/hmg/ddl471  0.4
2007 Higashi S, Moore DJ, Colebrooke RE, Biskup S, Dawson VL, Arai H, Dawson TM, Emson PC. Expression and localization of Parkinson's disease-associated leucine-rich repeat kinase 2 in the mouse brain. Journal of Neurochemistry. 100: 368-81. PMID 17101029 DOI: 10.1111/j.1471-4159.2006.04246.x  0.4
2006 Biskup S, Moore DJ, Celsi F, Higashi S, West AB, Andrabi SA, Kurkinen K, Yu SW, Savitt JM, Waldvogel HJ, Faull RL, Emson PC, Torp R, Ottersen OP, Dawson TM, et al. Localization of LRRK2 to membranous and vesicular structures in mammalian brain. Annals of Neurology. 60: 557-69. PMID 17120249 DOI: 10.1002/ana.21019  0.4
2006 Biskup S, Moore DJ. Detrimental deletions: mitochondria, aging and Parkinson's disease. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 28: 963-7. PMID 16998822 DOI: 10.1002/bies.20471  0.4
2006 Moore DJ, Dawson VL, Dawson TM. Lessons from Drosophila models of DJ-1 deficiency. Science of Aging Knowledge Environment : Sage Ke. 2006: pe2. PMID 16407572 DOI: 10.1126/sageke.2006.2.pe2  0.4
2005 Smith WW, Pei Z, Jiang H, Moore DJ, Liang Y, West AB, Dawson VL, Dawson TM, Ross CA. Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration. Proceedings of the National Academy of Sciences of the United States of America. 102: 18676-81. PMID 16352719 DOI: 10.1073/pnas.0508052102  0.4
2005 West AB, Moore DJ, Biskup S, Bugayenko A, Smith WW, Ross CA, Dawson VL, Dawson TM. Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity. Proceedings of the National Academy of Sciences of the United States of America. 102: 16842-7. PMID 16269541 DOI: 10.1073/pnas.0507360102  0.4
2005 Moore DJ, West AB, Dawson VL, Dawson TM. Molecular pathophysiology of Parkinson's disease. Annual Review of Neuroscience. 28: 57-87. PMID 16022590 DOI: 10.1146/annurev.neuro.28.061604.135718  0.4
2005 Zhang L, Shimoji M, Thomas B, Moore DJ, Yu SW, Marupudi NI, Torp R, Torgner IA, Ottersen OP, Dawson TM, Dawson VL. Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis. Human Molecular Genetics. 14: 2063-73. PMID 15944198 DOI: 10.1093/hmg/ddi211  0.4
2005 Moore DJ, Zhang L, Troncoso J, Lee MK, Hattori N, Mizuno Y, Dawson TM, Dawson VL. Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress. Human Molecular Genetics. 14: 71-84. PMID 15525661 DOI: 10.1093/hmg/ddi007  0.4
2003 Moore DJ, Zhang L, Dawson TM, Dawson VL. A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo-oligomerization. Journal of Neurochemistry. 87: 1558-67. PMID 14713311  0.4
2003 Moore DJ, Murdock PR, Watson JM, Faull RL, Waldvogel HJ, Szekeres PG, Wilson S, Freeman KB, Emson PC. GPR105, a novel Gi/o-coupled UDP-glucose receptor expressed on brain glia and peripheral immune cells, is regulated by immunologic challenge: possible role in neuroimmune function. Brain Research. Molecular Brain Research. 118: 10-23. PMID 14559350 DOI: 10.1016/S0169-328X(03)00330-9  0.4
2003 Moore DJ, Dawson VL, Dawson TM. Role for the ubiquitin-proteasome system in Parkinson's disease and other neurodegenerative brain amyloidoses. Neuromolecular Medicine. 4: 95-108. PMID 14528055 DOI: 10.1385/NMM:4:1-2:95  0.4
2003 Moore DJ, Dawson VL, Dawson TM. Genetics of Parkinson's disease: what do mutations in DJ-1 tell us? Annals of Neurology. 54: 281-2. PMID 12953259 DOI: 10.1002/ana.10740  0.4
2002 Moore DJ, Chambers JK, Murdock PR, Emson PC. Human Ntera-2/D1 neuronal progenitor cells endogenously express a functional P2Y1 receptor Neuropharmacology. 43: 966-978. PMID 12423666 DOI: 10.1016/S0028-3908(02)00177-6  0.4
2001 Freeman K, Tsui P, Moore D, Emson PC, Vawter L, Naheed S, Lane P, Bawagan H, Herrity N, Murphy K, Sarau HM, Ames RS, Wilson S, Livi GP, Chambers JK. Cloning, pharmacology, and tissue distribution of G-protein-coupled receptor GPR105 (KIAA0001) rodent orthologs Genomics. 78: 124-128. PMID 11735218 DOI: 10.1006/geno.2001.6662  0.4
2001 Moore DJ, Chambers JK, Wahlin JP, Tan KB, Moore GB, Jenkins O, Emson PC, Murdock PR. Expression pattern of human P2Y receptor subtypes: A quantitative reverse transcription-polymerase chain reaction study Biochimica Et Biophysica Acta - Gene Structure and Expression. 1521: 107-119. PMID 11690642 DOI: 10.1016/S0167-4781(01)00291-3  0.4
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