Warren D. Hirst - Publications

Imperial College, London, London, England, United Kingdom 

58 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Ugbode CI, Smith I, Whalley BJ, Hirst WD, Rattray M. SHH signalling mediates astrocyte crosstalk with neurons to confer neuroprotection. Journal of Neurochemistry. PMID 28485896 DOI: 10.1111/jnc.14064  0.4
2016 Volpicelli-Daley LA, Abdelmotilib H, Liu Z, Stoyka L, Daher JP, Milnerwood AJ, Unni VK, Hirst WD, Yue Z, Zhao HT, Fraser K, Kennedy RE, West AB. G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 7415-27. PMID 27413152 DOI: 10.1523/JNEUROSCI.3642-15.2016  0.6
2016 Ugbode CI, Hirst WD, Rattray M. Astrocytes Grown in Alvetex(®) Three Dimensional Scaffolds Retain a Non-reactive Phenotype. Neurochemical Research. PMID 27099962 DOI: 10.1007/s11064-016-1911-3  0.4
2015 Norkett R, Modi S, Birsa N, Atkin TA, Ivankovic D, Pathania M, Trossbach SV, Korth C, Hirst WD, Kittler JT. DISC1-dependent Regulation of Mitochondrial Dynamics Controls the Morphogenesis of Complex Neuronal Dendrites. The Journal of Biological Chemistry. PMID 26553875 DOI: 10.1074/jbc.M115.699447  0.6
2015 Henry AG, Aghamohammadzadeh S, Samaroo H, Chen Y, Mou K, Needle E, Hirst WD. Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression. Human Molecular Genetics. 24: 6013-28. PMID 26251043 DOI: 10.1093/hmg/ddv314  0.6
2015 Daher JP, Abdelmotilib HA, Hu X, Volpicelli-Daley LA, Moehle MS, Fraser KB, Needle E, Chen Y, Steyn SJ, Galatsis P, Hirst WD, West AB. LRRK2 Pharmacological Inhibition Abates α-Synuclein Induced Neurodegeneration. The Journal of Biological Chemistry. PMID 26078453 DOI: 10.1074/jbc.M115.660001  0.6
2015 Berger Z, Perkins S, Ambroise C, Oborski C, Calabrese M, Noell S, Riddell D, Hirst WD. Tool compounds robustly increase turnover of an artificial substrate by glucocerebrosidase in human brain lysates. Plos One. 10: e0119141. PMID 25763858 DOI: 10.1371/journal.pone.0119141  0.6
2015 Henderson JL, Kormos BL, Hayward MM, Coffman KJ, Jasti J, Kurumbail RG, Wager TT, Verhoest PR, Noell GS, Chen Y, Needle E, Berger Z, Steyn SJ, Houle C, Hirst WD, et al. Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. Journal of Medicinal Chemistry. 58: 419-32. PMID 25353650 DOI: 10.1021/jm5014055  0.6
2014 Galatsis P, Henderson JL, Kormos BL, Han S, Kurumbail RG, Wager TT, Verhoest PR, Noell GS, Chen Y, Needle E, Berger Z, Steyn SJ, Houle C, Hirst WD. Kinase domain inhibition of leucine rich repeat kinase 2 (LRRK2) using a [1,2,4]triazolo[4,3-b]pyridazine scaffold. Bioorganic & Medicinal Chemistry Letters. 24: 4132-40. PMID 25113930 DOI: 10.1016/j.bmcl.2014.07.052  0.6
2014 Ugbode CI, Hirst WD, Rattray M. Neuronal influences are necessary to produce mitochondrial co-localization with glutamate transporters in astrocytes. Journal of Neurochemistry. 130: 668-77. PMID 24814819 DOI: 10.1111/jnc.12759  0.6
2014 Birsa N, Norkett R, Wauer T, Mevissen TE, Wu HC, Foltynie T, Bhatia K, Hirst WD, Komander D, Plun-Favreau H, Kittler JT. Lysine 27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase. The Journal of Biological Chemistry. 289: 14569-82. PMID 24671417 DOI: 10.1074/jbc.M114.563031  0.6
2014 Shen W, Henry AG, Paumier KL, Li L, Mou K, Dunlop J, Berger Z, Hirst WD. Inhibition of glucosylceramide synthase stimulates autophagy flux in neurons. Journal of Neurochemistry. 129: 884-94. PMID 24494600 DOI: 10.1111/jnc.12672  0.6
2014 Luerman GC, Nguyen C, Samaroo H, Loos P, Xi H, Hurtado-Lorenzo A, Needle E, Stephen Noell G, Galatsis P, Dunlop J, Geoghegan KF, Hirst WD. Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1. Journal of Neurochemistry. 128: 561-76. PMID 24117733 DOI: 10.1111/jnc.12483  0.6
2014 Galatsis P, Henderson J, Kormos BL, Hirst WD. Development of LRRK2 kinase inhibitors for parkinson's disease Annual Reports in Medicinal Chemistry. 49: 43-58. DOI: 10.1016/B978-0-12-800167-7.00004-3  0.6
2013 Li L, Nadanaciva S, Berger Z, Shen W, Paumier K, Schwartz J, Mou K, Loos P, Milici AJ, Dunlop J, Hirst WD. Human A53T α-synuclein causes reversible deficits in mitochondrial function and dynamics in primary mouse cortical neurons. Plos One. 8: e85815. PMID 24392030 DOI: 10.1371/journal.pone.0085815  0.6
2010 Pungaliya PP, Bai Y, Lipinski K, Anand VS, Sen S, Brown EL, Bates B, Reinhart PH, West AB, Hirst WD, Braithwaite SP. Identification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motif. Plos One. 5: e13672. PMID 21060682 DOI: 10.1371/journal.pone.0013672  0.6
2010 Braithwaite SP, Schmid RS, He DN, Sung ML, Cho S, Resnick L, Monaghan MM, Hirst WD, Essrich C, Reinhart PH, Lo DC. Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease. Neurobiology of Disease. 39: 311-7. PMID 20451607 DOI: 10.1016/j.nbd.2010.04.015  0.6
2010 Childers WE, Havran LM, Asselin M, Bicksler JJ, Chong DC, Grosu GT, Shen Z, Abou-Gharbia MA, Bach AC, Harrison BL, Kagan N, Kleintop T, Magolda R, Marathias V, Robichaud AJ, ... ... Hirst WD, et al. The synthesis and biological evaluation of quinolyl-piperazinyl piperidines as potent serotonin 5-HT1A antagonists. Journal of Medicinal Chemistry. 53: 4066-84. PMID 20443629 DOI: 10.1021/jm1000908  0.6
2010 Donnell AF, Dollings PJ, Butera JA, Dietrich AJ, Lipinski KK, Ghavami A, Hirst WD. Identification of pyridazino[4,5-b]indolizines as selective PDE4B inhibitors. Bioorganic & Medicinal Chemistry Letters. 20: 2163-7. PMID 20202838 DOI: 10.1016/j.bmcl.2010.02.044  0.6
2010 Cole DC, Gross JL, Comery TA, Aschmies S, Hirst WD, Kelley C, Kim JI, Kubek K, Ning X, Platt BJ, Robichaud AJ, Solvibile WR, Stock JR, Tawa G, Williams MJ, et al. Benzimidazole- and indole-substituted 1,3'-bipyrrolidine benzamides as histamine H3 receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 20: 1237-40. PMID 20042333 DOI: 10.1016/j.bmcl.2009.11.122  0.6
2009 Atkinson PJ, Dellovade T, Albers D, Von Schack D, Saraf K, Needle E, Reinhart PH, Hirst WD. Sonic Hedgehog signaling in astrocytes is dependent on p38 mitogen-activated protein kinase and G-protein receptor kinase 2. Journal of Neurochemistry. 108: 1539-49. PMID 19183261 DOI: 10.1111/j.1471-4159.2009.05900.x  0.6
2009 Anand VS, Reichling LJ, Lipinski K, Stochaj W, Duan W, Kelleher K, Pungaliya P, Brown EL, Reinhart PH, Somberg R, Hirst WD, Riddle SM, Braithwaite SP. Investigation of leucine-rich repeat kinase 2 : enzymological properties and novel assays. The Febs Journal. 276: 466-78. PMID 19076219 DOI: 10.1111/j.1742-4658.2008.06789.x  0.6
2009 Haydar SN, Yun H, Staal RGW, Hirst WD. Small-molecule protein-protein interaction inhibitors as therapeutic agents for neurodegenerative diseases: Recent progress and future directions Annual Reports in Medicinal Chemistry. 44: 51-69. DOI: 10.1016/S0065-7743(09)04403-0  0.6
2008 Foley AG, Hirst WD, Gallagher HC, Barry C, Hagan JJ, Upton N, Walsh FS, Hunter AJ, Regan CM. The selective 5-HT6 receptor antagonists SB-271046 and SB-399885 potentiate NCAM PSA immunolabeling of dentate granule cells, but not neurogenesis, in the hippocampal formation of mature Wistar rats. Neuropharmacology. 54: 1166-74. PMID 18455201 DOI: 10.1016/j.neuropharm.2008.03.012  0.6
2008 Liu F, Day M, Muñiz LC, Bitran D, Arias R, Revilla-Sanchez R, Grauer S, Zhang G, Kelley C, Pulito V, Sung A, Mervis RF, Navarra R, Hirst WD, Reinhart PH, et al. Activation of estrogen receptor-beta regulates hippocampal synaptic plasticity and improves memory. Nature Neuroscience. 11: 334-43. PMID 18297067 DOI: 10.1038/nn2057  0.6
2008 Hirst WD, Andree TH, Aschmies S, Childers WE, Comery TA, Dawson LA, Day M, Feingold IB, Grauer SM, Harrison BL, Hughes ZA, Kao J, Kelly MG, van der Lee H, Rosenzweig-Lipson S, et al. Correlating efficacy in rodent cognition models with in vivo 5-hydroxytryptamine1a receptor occupancy by a novel antagonist, (R)-N-(2-methyl-(4-indolyl-1-piperazinyl)ethyl)-N-(2-pyridinyl)-cyclohexane carboxamide (WAY-101405). The Journal of Pharmacology and Experimental Therapeutics. 325: 134-45. PMID 18182558 DOI: 10.1124/jpet.107.133082  0.6
2007 Riddell DR, Zhou H, Comery TA, Kouranova E, Lo CF, Warwick HK, Ring RH, Kirksey Y, Aschmies S, Xu J, Kubek K, Hirst WD, Gonzales C, Chen Y, Murphy E, et al. The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease. Molecular and Cellular Neurosciences. 34: 621-8. PMID 17336088 DOI: 10.1016/j.mcn.2007.01.011  0.6
2007 Medhurst AD, Atkins AR, Beresford IJ, Brackenborough K, Briggs MA, Calver AR, Cilia J, Cluderay JE, Crook B, Davis JB, Davis RK, Davis RP, Dawson LA, Foley AG, Gartlon J, ... ... Hirst WD, et al. GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models. The Journal of Pharmacology and Experimental Therapeutics. 321: 1032-45. PMID 17327487 DOI: 10.1124/jpet.107.120311  0.6
2007 Medhurst AD, Briggs MA, Bruton G, Calver AR, Chessell I, Crook B, Davis JB, Davis RP, Foley AG, Heslop T, Hirst WD, Medhurst SJ, Ociepka S, Ray A, Regan CM, et al. Structurally novel histamine H3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced secondary allodynia in rats. Biochemical Pharmacology. 73: 1182-94. PMID 17276409 DOI: 10.1016/j.bcp.2007.01.007  0.6
2007 Day M, Pan JB, Buckley MJ, Cronin E, Hollingsworth PR, Hirst WD, Navarra R, Sullivan JP, Decker MW, Fox GB. Differential effects of ciproxifan and nicotine on impulsivity and attention measures in the 5-choice serial reaction time test. Biochemical Pharmacology. 73: 1123-34. PMID 17214974 DOI: 10.1016/j.bcp.2006.12.004  0.6
2006 Hirst WD, Stean TO, Rogers DC, Sunter D, Pugh P, Moss SF, Bromidge SM, Riley G, Smith DR, Bartlett S, Heidbreder CA, Atkins AR, Lacroix LP, Dawson LA, Foley AG, et al. SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models. European Journal of Pharmacology. 553: 109-19. PMID 17069795 DOI: 10.1016/j.ejphar.2006.09.049  0.6
2006 Marcos B, Gil-Bea FJ, Hirst WD, García-Alloza M, Ramírez MJ. Lack of localization of 5-HT6 receptors on cholinergic neurons: implication of multiple neurotransmitter systems in 5-HT6 receptor-mediated acetylcholine release. The European Journal of Neuroscience. 24: 1299-306. PMID 16987217 DOI: 10.1111/j.1460-9568.2006.05003.x  0.6
2006 Ghavami A, Hirst WD, Novak TJ. Selective phosphodiesterase (PDE)-4 inhibitors: a novel approach to treating memory deficit? Drugs in R&D. 7: 63-71. PMID 16542053 DOI: 10.2165/00126839-200607020-00001  0.6
2006 Haydar SN, Hirst WD. Neuroprotective Agents for the Treatment of Ischemic and Hemorrhagic Stroke Annual Reports in Medicinal Chemistry. 41: 39-57. DOI: 10.1016/S0065-7743(06)41003-4  0.6
2004 Gadalla AE, Pearson T, Currie AJ, Dale N, Hawley SA, Sheehan M, Hirst W, Michel AD, Randall A, Hardie DG, Frenguelli BG. AICA riboside both activates AMP-activated protein kinase and competes with adenosine for the nucleoside transporter in the CA1 region of the rat hippocampus. Journal of Neurochemistry. 88: 1272-82. PMID 15009683 DOI: 10.1046/j.1471-4159.2003.02253.x  0.6
2004 Foley AG, Murphy KJ, Hirst WD, Gallagher HC, Hagan JJ, Upton N, Walsh FS, Regan CM. The 5-HT(6) receptor antagonist SB-271046 reverses scopolamine-disrupted consolidation of a passive avoidance task and ameliorates spatial task deficits in aged rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 93-100. PMID 14571256 DOI: 10.1038/sj.npp.1300332  0.6
2004 Garcia-Alloza M, Hirst WD, Chen CP, Lasheras B, Francis PT, Ramírez MJ. Differential involvement of 5-HT(1B/1D) and 5-HT6 receptors in cognitive and non-cognitive symptoms in Alzheimer's disease. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 410-6. PMID 14571255 DOI: 10.1038/sj.npp.1300330  0.6
2003 Hirst WD, Abrahamsen B, Blaney FE, Calver AR, Aloj L, Price GW, Medhurst AD. Differences in the central nervous system distribution and pharmacology of the mouse 5-hydroxytryptamine-6 receptor compared with rat and human receptors investigated by radioligand binding, site-directed mutagenesis, and molecular modeling. Molecular Pharmacology. 64: 1295-308. PMID 14645659 DOI: 10.1124/mol.64.6.1295  0.6
2003 Hirst WD, Babbs AJ, Green A, Minton JA, Shaw TE, Wise A, Rice SQ, Pangalos MN, Price GW. Pharmacological characterisation of a cell line expressing GABA B1b and GABA B2 receptor subunits. Biochemical Pharmacology. 65: 1103-13. PMID 12663046 DOI: 10.1016/S0006-2952(02)01658-1  0.6
2002 Couve A, Thomas P, Calver AR, Hirst WD, Pangalos MN, Walsh FS, Smart TG, Moss SJ. Cyclic AMP-dependent protein kinase phosphorylation facilitates GABA(B) receptor-effector coupling. Nature Neuroscience. 5: 415-24. PMID 11976702 DOI: 10.1038/nn833  0.6
2002 Stean TO, Hirst WD, Thomas DR, Price GW, Rogers D, Riley G, Bromidge SM, Serafinowska HT, Smith DR, Bartlett S, Deeks N, Duxon M, Upton N. Pharmacological profile of SB-357134: a potent, selective, brain penetrant, and orally active 5-HT(6) receptor antagonist. Pharmacology, Biochemistry, and Behavior. 71: 645-54. PMID 11888556 DOI: 10.1016/S0091-3057(01)00742-0  0.6
2001 Lanneau C, Green A, Hirst WD, Wise A, Brown JT, Donnier E, Charles KJ, Wood M, Davies CH, Pangalos MN. Gabapentin is not a GABAB receptor agonist. Neuropharmacology. 41: 965-75. PMID 11747901 DOI: 10.1016/S0028-3908(01)00140-X  0.6
2001 Robbins MJ, Calver AR, Filippov AK, Hirst WD, Russell RB, Wood MD, Nasir S, Couve A, Brown DA, Moss SJ, Pangalos MN. GABA(B2) is essential for g-protein coupling of the GABA(B) receptor heterodimer. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 8043-52. PMID 11588177  0.6
2001 Prosser HM, Gill CH, Hirst WD, Grau E, Robbins M, Calver A, Soffin EM, Farmer CE, Lanneau C, Gray J, Schenck E, Warmerdam BS, Clapham C, Reavill C, Rogers DC, et al. Epileptogenesis and enhanced prepulse inhibition in GABA(B1)-deficient mice. Molecular and Cellular Neurosciences. 17: 1059-70. PMID 11414794 DOI: 10.1006/mcne.2001.0995  0.6
2001 Read SJ, Hirst WD, Upton N, Parsons AA. Cortical spreading depression produces increased cGMP levels in cortex and brain stem that is inhibited by tonabersat (SB-220453) but not sumatriptan. Brain Research. 891: 69-77. PMID 11164810 DOI: 10.1016/S0006-8993(00)03191-7  0.6
2001 Calver AR, Robbins MJ, Cosio C, Rice SQ, Babbs AJ, Hirst WD, Boyfield I, Wood MD, Russell RB, Price GW, Couve A, Moss SJ, Pangalos MN. The C-terminal domains of the GABA(b) receptor subunits mediate intracellular trafficking but are not required for receptor signaling. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 1203-10. PMID 11160390  0.6
2000 Wood MD, Murkitt KL, Rice SQ, Testa T, Punia PK, Stammers M, Jenkins O, Elshourbagy NA, Shabon U, Taylor SJ, Gager TL, Minton J, Hirst WD, Price GW, Pangalos M. The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. British Journal of Pharmacology. 131: 1050-4. PMID 11082110 DOI: 10.1038/sj.bjp.0703682  0.6
2000 Langmead CJ, Szekeres PG, Chambers JK, Ratcliffe SJ, Jones DN, Hirst WD, Price GW, Herdon HJ. Characterization of the binding of [(125)I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor. British Journal of Pharmacology. 131: 683-8. PMID 11030716 DOI: 10.1038/sj.bjp.0703617  0.6
2000 Routledge C, Bromidge SM, Moss SF, Price GW, Hirst W, Newman H, Riley G, Gager T, Stean T, Upton N, Clarke SE, Brown AM, Middlemiss DN. Characterization of SB-271046: a potent, selective and orally active 5-HT(6) receptor antagonist. British Journal of Pharmacology. 130: 1606-12. PMID 10928964 DOI: 10.1038/sj.bjp.0703457  0.6
2000 Hirst WD, Minton JA, Bromidge SM, Moss SF, Latter AJ, Riley G, Routledge C, Middlemiss DN, Price GW. Characterization of [(125)I]-SB-258585 binding to human recombinant and native 5-HT(6) receptors in rat, pig and human brain tissue. British Journal of Pharmacology. 130: 1597-605. PMID 10928963 DOI: 10.1038/sj.bjp.0703458  0.6
2000 Bendotti C, Guglielmetti F, Tortarolo M, Samanin R, Hirst WD. Differential expression of S100beta and glial fibrillary acidic protein in the hippocampus after kainic acid-induced lesions and mossy fiber sprouting in adult rat. Experimental Neurology. 161: 317-29. PMID 10683297 DOI: 10.1006/exnr.1999.7262  0.6
1999 Medhurst AD, Hirst WD, Jerman JC, Meakin J, Roberts JC, Testa T, Smart D. Molecular and pharmacological characterization of a functional tachykinin NK3 receptor cloned from the rabbit iris sphincter muscle. British Journal of Pharmacology. 128: 627-36. PMID 10516642 DOI: 10.1038/sj.bjp.0702854  0.6
1999 Young KA, Hirst WD, Solito E, Wilkin GP. De novo expression of lipocortin-1 in reactive microglia and astrocytes in kainic acid lesioned rat cerebellum. Glia. 26: 333-43. PMID 10383052 DOI: 10.1002/(SICI)1098-1136(199906)26:4<333::AID-GLIA7>3.0.CO;2-S  0.6
1999 Hirst WD, Young KA, Newton R, Allport VC, Marriott DR, Wilkin GP. Expression of COX-2 by normal and reactive astrocytes in the adult rat central nervous system. Molecular and Cellular Neurosciences. 13: 57-68. PMID 10049531 DOI: 10.1006/mcne.1998.0731  0.6
1998 Hirst WD, Cheung NY, Rattray M, Price GW, Wilkin GP. Cultured astrocytes express messenger RNA for multiple serotonin receptor subtypes, without functional coupling of 5-HT1 receptor subtypes to adenylyl cyclase. Brain Research. Molecular Brain Research. 61: 90-9. PMID 9795156 DOI: 10.1016/S0169-328X(98)00206-X  0.6
1998 Hirst WD, Price GW, Rattray M, Wilkin GP. Serotonin transporters in adult rat brain astrocytes revealed by [3H]5-HT uptake into glial plasmalemmal vesicles. Neurochemistry International. 33: 11-22. PMID 9694037 DOI: 10.1016/S0197-0186(05)80003-8  0.6
1998 Davletov BA, Meunier FA, Ashton AC, Matsushita H, Hirst WD, Lelianova VG, Wilkin GP, Dolly JO, Ushkaryov YA. Vesicle exocytosis stimulated by alpha-latrotoxin is mediated by latrophilin and requires both external and stored Ca2+. The Embo Journal. 17: 3909-20. PMID 9670008 DOI: 10.1093/emboj/17.14.3909  0.6
1997 Hirst WD, Price GW, Rattray M, Wilkin GP. Identification of 5-hydroxytryptamine receptors positively coupled to adenylyl cyclase in rat cultured astrocytes. British Journal of Pharmacology. 120: 509-15. PMID 9031757 DOI: 10.1038/sj.bjp.0700921  0.6
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