Linda J. Van Eldik, Ph.D. - Publications

Affiliations: 
Sanders-Brown Center on Aging University of Kentucky, Lexington, KY 
Area:
glia, neuroinflammation, drug design, Alzheimer's disease

194 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Morganti JM, Goulding DS, Van Eldik LJ. Deletion of p38α MAPK in microglia blunts trauma-induced inflammatory responses in mice. Journal of Neuroinflammation. 16: 98. PMID 31077217 DOI: 10.1186/s12974-019-1493-5  0.64
2016 Ighodaro ET, Abner EL, Fardo DW, Lin AL, Katsumata Y, Schmitt FA, Kryscio RJ, Jicha GA, Neltner JH, Monsell SE, Kukull WA, Moser DK, Appiah F, Bachstetter AD, Van Eldik LJ, et al. Risk factors and global cognitive status related to brain arteriolosclerosis in elderly individuals. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 26738751 DOI: 10.1177/0271678X15621574  0.92
2015 Neltner JH, Abner EL, Jicha GA, Schmitt FA, Patel E, Poon LW, Marla G, Green RC, Davey A, Johnson MA, Jazwinski SM, Kim S, Davis D, Woodard JL, Kryscio RJ, ... Van Eldik LJ, et al. Brain pathologies in extreme old age. Neurobiology of Aging. PMID 26597697 DOI: 10.1016/j.neurobiolaging.2015.10.009  0.36
2015 Ighodaro ET, Jicha GA, Schmitt FA, Neltner JH, Abner EL, Kryscio RJ, Smith CD, Duplessis T, Anderson S, Patel E, Bachstetter A, Van Eldik LJ, Nelson PT. Hippocampal Sclerosis of Aging Can Be Segmental: Two Cases and Review of the Literature. Journal of Neuropathology and Experimental Neurology. 74: 642-52. PMID 26083567 DOI: 10.1097/NEN.0000000000000204  1
2015 Bachstetter AD, Van Eldik LJ, Schmitt FA, Neltner JH, Ighodaro ET, Webster SJ, Patel E, Abner EL, Kryscio RJ, Nelson PT. Disease-related microglia heterogeneity in the hippocampus of Alzheimer's disease, dementia with Lewy bodies, and hippocampal sclerosis of aging. Acta Neuropathologica Communications. 3: 32. PMID 26001591 DOI: 10.1186/s40478-015-0209-z  0.92
2015 Webster SJ, Van Eldik LJ, Watterson DM, Bachstetter AD. Closed head injury in an age-related Alzheimer mouse model leads to an altered neuroinflammatory response and persistent cognitive impairment. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 6554-69. PMID 25904805 DOI: 10.1523/JNEUROSCI.0291-15.2015  1
2015 Bachstetter AD, Webster SJ, Goulding DS, Morton JE, Watterson DM, Van Eldik LJ. Attenuation of traumatic brain injury-induced cognitive impairment in mice by targeting increased cytokine levels with a small molecule experimental therapeutic. Journal of Neuroinflammation. 12: 69. PMID 25886256 DOI: 10.1186/s12974-015-0289-5  1
2015 Tai LM, Ghura S, Koster KP, Liakaite V, Maienschein-Cline M, Kanabar P, Collins N, Ben-Aissa M, Lei AZ, Bahroos N, Green SJ, Hendrickson B, Van Eldik LJ, LaDu MJ. APOE-modulated Aβ-induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective. Journal of Neurochemistry. 133: 465-88. PMID 25689586 DOI: 10.1111/jnc.13072  1
2015 Roy SM, Grum-Tokars VL, Schavocky JP, Saeed F, Staniszewski A, Teich AF, Arancio O, Bachstetter AD, Webster SJ, Van Eldik LJ, Minasov G, Anderson WF, Pelletier JC, Watterson DM. Targeting human central nervous system protein kinases: An isoform selective p38αMAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models. Acs Chemical Neuroscience. 6: 666-80. PMID 25676389 DOI: 10.1021/acschemneuro.5b00002  1
2015 Xing B, Bachstetter AD, Van Eldik LJ. Inhibition of neuronal p38α, but not p38β MAPK, provides neuroprotection against three different neurotoxic insults. Journal of Molecular Neuroscience : Mn. 55: 509-18. PMID 25012593 DOI: 10.1007/s12031-014-0372-x  1
2014 Bachstetter AD, Xing B, Van Eldik LJ. The p38alpha mitogen-activated protein kinase limits the CNS proinflammatory cytokine response to systemic lipopolysaccharide, potentially through an IL-10 dependent mechanism. Journal of Neuroinflammation. 11: 175. PMID 25297465 DOI: 10.1186/s12974-014-0175-6  1
2014 Kryscio RJ, Abner EL, Cooper GE, Fardo DW, Jicha GA, Nelson PT, Smith CD, Van Eldik LJ, Wan L, Schmitt FA. Self-reported memory complaints: implications from a longitudinal cohort with autopsies. Neurology. 83: 1359-65. PMID 25253756 DOI: 10.1212/WNL.0000000000000856  1
2014 Bachstetter AD, Webster SJ, Tu T, Goulding DS, Haiech J, Watterson DM, Van Eldik LJ. Generation and behavior characterization of CaMKIIβ knockout mice. Plos One. 9: e105191. PMID 25127391 DOI: 10.1371/journal.pone.0105191  1
2014 Gold BT, Zhu Z, Brown CA, Andersen AH, LaDu MJ, Tai L, Jicha GA, Kryscio RJ, Estus S, Nelson PT, Scheff SW, Abner E, Schmitt FA, Van Eldik LJ, Smith CD. White matter integrity is associated with cerebrospinal fluid markers of Alzheimer's disease in normal adults. Neurobiology of Aging. 35: 2263-71. PMID 24866404 DOI: 10.1016/j.neurobiolaging.2014.04.030  1
2014 Webster SJ, Bachstetter AD, Nelson PT, Schmitt FA, Van Eldik LJ. Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models. Frontiers in Genetics. 5: 88. PMID 24795750 DOI: 10.3389/fgene.2014.00088  1
2014 Bachstetter AD, Watterson DM, Van Eldik LJ. Target engagement analysis and link to pharmacodynamic endpoint for a novel class of CNS-penetrant and efficacious p38α MAPK inhibitors. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 9: 454-60. PMID 24789302 DOI: 10.1007/s11481-014-9543-3  1
2014 Nelson PT, Estus S, Abner EL, Parikh I, Malik M, Neltner JH, Ighodaro E, Wang WX, Wilfred BR, Wang LS, Kukull WA, Nandakumar K, Farman ML, Poon WW, Corrada MM, ... ... Van Eldik LJ, et al. ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology. Acta Neuropathologica. 127: 825-43. PMID 24770881 DOI: 10.1007/s00401-014-1282-2  1
2014 Rowe RK, Striz M, Bachstetter AD, Van Eldik LJ, Donohue KD, O'Hara BF, Lifshitz J. Diffuse brain injury induces acute post-traumatic sleep. Plos One. 9: e82507. PMID 24416145 DOI: 10.1371/journal.pone.0082507  1
2014 Abner EL, Nelson PT, Schmitt FA, Browning SR, Fardo DW, Wan L, Jicha GA, Cooper GE, Smith CD, Caban-Holt AM, Van Eldik LJ, Kryscio RJ. Self-reported head injury and risk of late-life impairment and AD pathology in an AD center cohort. Dementia and Geriatric Cognitive Disorders. 37: 294-306. PMID 24401791 DOI: 10.1159/000355478  1
2014 Neltner JH, Abner EL, Baker S, Schmitt FA, Kryscio RJ, Jicha GA, Smith CD, Hammack E, Kukull WA, Brenowitz WD, Van Eldik LJ, Nelson PT. Arteriolosclerosis that affects multiple brain regions is linked to hippocampal sclerosis of ageing. Brain : a Journal of Neurology. 137: 255-67. PMID 24271328 DOI: 10.1093/brain/awt318  1
2013 Bachstetter AD, Webster SJ, Van Eldik LJ, Cambi F. Clinically relevant intronic splicing enhancer mutation in myelin proteolipid protein leads to progressive microglia and astrocyte activation in white and gray matter regions of the brain. Journal of Neuroinflammation. 10: 146. PMID 24314267 DOI: 10.1186/1742-2094-10-146  1
2013 Nelson PT, Smith CD, Abner EL, Wilfred BJ, Wang WX, Neltner JH, Baker M, Fardo DW, Kryscio RJ, Scheff SW, Jicha GA, Jellinger KA, Van Eldik LJ, Schmitt FA. Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease. Acta Neuropathologica. 126: 161-77. PMID 23864344 DOI: 10.1007/s00401-013-1154-1  1
2013 Watterson DM, Grum-Tokars VL, Roy SM, Schavocky JP, Bradaric BD, Bachstetter AD, Xing B, Dimayuga E, Saeed F, Zhang H, Staniszewski A, Pelletier JC, Minasov G, Anderson WF, Arancio O, ... Van Eldik LJ, et al. Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction. Plos One. 8: e66226. PMID 23840427 DOI: 10.1371/journal.pone.0066226  1
2013 Herrup K, Carrillo MC, Schenk D, Cacace A, Desanti S, Fremeau R, Bhat R, Glicksman M, May P, Swerdlow R, Van Eldik LJ, Bain LJ, Budd S. Beyond amyloid: getting real about nonamyloid targets in Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 9: 452-458.e1. PMID 23809366 DOI: 10.1016/j.jalz.2013.01.017  1
2013 Webster SJ, Bachstetter AD, Van Eldik LJ. Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's disease. Alzheimer's Research & Therapy. 5: 28. PMID 23705774 DOI: 10.1186/alzrt182  1
2013 Bachstetter AD, Rowe RK, Kaneko M, Goulding D, Lifshitz J, Van Eldik LJ. The p38α MAPK regulates microglial responsiveness to diffuse traumatic brain injury. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 6143-53. PMID 23554495 DOI: 10.1523/JNEUROSCI.5399-12.2013  1
2013 Kryscio RJ, Abner EL, Lin Y, Cooper GE, Fardo DW, Jicha GA, Nelson PT, Smith CD, Van Eldik LJ, Wan L, Schmitt FA. Adjusting for mortality when identifying risk factors for transitions to mild cognitive impairment and dementia. Journal of Alzheimer's Disease : Jad. 35: 823-32. PMID 23507772 DOI: 10.3233/JAD-122146  1
2013 Xing B, Bachstetter AD, Van Eldik LJ. Deficiency in p38β MAPK fails to inhibit cytokine production or protect neurons against inflammatory insult in in vitro and in vivo mouse models. Plos One. 8: e56852. PMID 23457629 DOI: 10.1371/journal.pone.0056852  1
2013 Tai LM, Bilousova T, Jungbauer L, Roeske SK, Youmans KL, Yu C, Poon WW, Cornwell LB, Miller CA, Vinters HV, Van Eldik LJ, Fardo DW, Estus S, Bu G, Gylys KH, et al. Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples. The Journal of Biological Chemistry. 288: 5914-26. PMID 23293020 DOI: 10.1074/jbc.M112.442103  1
2012 Furman JL, Sama DM, Gant JC, Beckett TL, Murphy MP, Bachstetter AD, Van Eldik LJ, Norris CM. Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 16129-40. PMID 23152597 DOI: 10.1523/JNEUROSCI.2323-12.2012  1
2012 Bachstetter AD, Norris CM, Sompol P, Wilcock DM, Goulding D, Neltner JH, St Clair D, Watterson DM, Van Eldik LJ. Early stage drug treatment that normalizes proinflammatory cytokine production attenuates synaptic dysfunction in a mouse model that exhibits age-dependent progression of Alzheimer's disease-related pathology. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 10201-10. PMID 22836255 DOI: 10.1523/JNEUROSCI.1496-12.2012  1
2012 Abner EL, Kryscio RJ, Cooper GE, Fardo DW, Jicha GA, Mendiondo MS, Nelson PT, Smith CD, Van Eldik LJ, Wan L, Schmitt FA. Mild cognitive impairment: statistical models of transition using longitudinal clinical data. International Journal of Alzheimer's Disease. 2012: 291920. PMID 22536535 DOI: 10.1155/2012/291920  1
2012 Schmitt FA, Nelson PT, Abner E, Scheff S, Jicha GA, Smith C, Cooper G, Mendiondo M, Danner DD, Van Eldik LJ, Caban-Holt A, Lovell MA, Kryscio RJ. University of Kentucky Sanders-Brown healthy brain aging volunteers: donor characteristics, procedures and neuropathology. Current Alzheimer Research. 9: 724-33. PMID 22471862  1
2012 Jicha GA, Abner EL, Schmitt FA, Kryscio RJ, Riley KP, Cooper GE, Stiles N, Mendiondo MS, Smith CD, Van Eldik LJ, Nelson PT. Preclinical AD Workgroup staging: pathological correlates and potential challenges. Neurobiology of Aging. 33: 622.e1-622.e16. PMID 21507528 DOI: 10.1016/j.neurobiolaging.2011.02.018  1
2012 Hu J, Van Eldik LJ. Regulation of Nitric Oxide Synthase by Calmodulin Calmodulin and Signal Transduction. 287-345. DOI: 10.1016/B978-0-08-092636-0.50010-4  0.96
2012 Van Eldik LJ, Watterson DM. Calmodulin and Calcium Signal Transduction: An Introduction Calmodulin and Signal Transduction. 1-15. DOI: 10.1016/B978-0-08-092636-0.50005-0  0.96
2012 Van Eldik LJ, Watterson DM. Preface Calmodulin and Signal Transduction. xi-xiv. DOI: 10.1016/B978-0-08-092636-0.50004-9  0.96
2012 Van Eldik LJ, Watterson DM. Calmodulin and Signal Transduction Calmodulin and Signal Transduction. 1-482.  0.96
2011 Xing B, Bachstetter AD, Van Eldik LJ. Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα. Molecular Neurodegeneration. 6: 84. PMID 22185458 DOI: 10.1186/1750-1326-6-84  1
2011 Bruce-Keller AJ, Gupta S, Knight AG, Beckett TL, McMullen JM, Davis PR, Murphy MP, Van Eldik LJ, St Clair D, Keller JN. Cognitive impairment in humanized APP×PS1 mice is linked to Aβ(1-42) and NOX activation. Neurobiology of Disease. 44: 317-26. PMID 21798347 DOI: 10.1016/j.nbd.2011.07.012  1
2011 Bachstetter AD, Xing B, de Almeida L, Dimayuga ER, Watterson DM, Van Eldik LJ. Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ). Journal of Neuroinflammation. 8: 79. PMID 21733175 DOI: 10.1186/1742-2094-8-79  1
2011 Nelson PT, Schmitt FA, Lin Y, Abner EL, Jicha GA, Patel E, Thomason PC, Neltner JH, Smith CD, Santacruz KS, Sonnen JA, Poon LW, Gearing M, Green RC, Woodard JL, ... Van Eldik LJ, et al. Hippocampal sclerosis in advanced age: clinical and pathological features. Brain : a Journal of Neurology. 134: 1506-18. PMID 21596774 DOI: 10.1093/brain/awr053  1
2011 Nelson PT, Head E, Schmitt FA, Davis PR, Neltner JH, Jicha GA, Abner EL, Smith CD, Van Eldik LJ, Kryscio RJ, Scheff SW. Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies. Acta Neuropathologica. 121: 571-87. PMID 21516511 DOI: 10.1007/s00401-011-0826-y  1
2011 Riley KP, Jicha GA, Davis D, Abner EL, Cooper GE, Stiles N, Smith CD, Kryscio RJ, Nelson PT, Van Eldik LJ, Schmitt FA. Prediction of preclinical Alzheimer's disease: longitudinal rates of change in cognition. Journal of Alzheimer's Disease : Jad. 25: 707-17. PMID 21498903 DOI: 10.3233/JAD-2011-102133  1
2011 Abner EL, Kryscio RJ, Schmitt FA, Santacruz KS, Jicha GA, Lin Y, Neltner JM, Smith CD, Van Eldik LJ, Nelson PT. "End-stage" neurofibrillary tangle pathology in preclinical Alzheimer's disease: fact or fiction? Journal of Alzheimer's Disease : Jad. 25: 445-53. PMID 21471646 DOI: 10.3233/JAD-2011-101980  1
2010 Bachstetter AD, Van Eldik LJ. The p38 MAP Kinase Family as Regulators of Proinflammatory Cytokine Production in Degenerative Diseases of the CNS. Aging and Disease. 1: 199-211. PMID 22720195  1
2010 Nelson PT, Schmitt FA, Jicha GA, Kryscio RJ, Abner EL, Smith CD, Van Eldik LJ, Markesbery WR. Association between male gender and cortical Lewy body pathology in large autopsy series. Journal of Neurology. 257: 1875-81. PMID 20563821 DOI: 10.1007/s00415-010-5630-4  1
2009 Chico LK, Van Eldik LJ, Watterson DM. Targeting protein kinases in central nervous system disorders. Nature Reviews. Drug Discovery. 8: 892-909. PMID 19876042 DOI: 10.1038/nrd2999  1
2009 Thompson WL, Van Eldik LJ. Inflammatory cytokines stimulate the chemokines CCL2/MCP-1 and CCL7/MCP-3 through NFkB and MAPK dependent pathways in rat astrocytes [corrected]. Brain Research. 1287: 47-57. PMID 19577550 DOI: 10.1016/j.brainres.2009.06.081  1
2009 Marchenko AV, Sidorova MV, Sekridova AV, Bushuev VN, Lakomkin VL, Orlova TsR, Stepanova OV, Kapel'ko VI, Watterson DM, Van Eldik LJ, Bespalova ZhD, ShirinskiÄ­ VP. [Penetrating peptide inhibitor of the myosin light chain kinase suppresses hyperpermeability of vascular endothelium]. RossiÄ­Skii FiziologicheskiÄ­ Zhurnal Imeni I.M. Sechenova / RossiÄ­Skaia Akademiia Nauk. 95: 507-15. PMID 19569527  1
2009 Somera-Molina KC, Nair S, Van Eldik LJ, Watterson DM, Wainwright MS. Enhanced microglial activation and proinflammatory cytokine upregulation are linked to increased susceptibility to seizures and neurologic injury in a 'two-hit' seizure model. Brain Research. 1282: 162-72. PMID 19501063 DOI: 10.1016/j.brainres.2009.05.073  1
2009 Thompson WL, Van Eldik LJ. Corrigendum to "Inflammatory cytokines stimulate the chemokines CCL2/MCP-1 and CCL7/MCP-7 through NFκB and MAPK dependent pathways in rat astrocytes" [Brain Res. 1287 (2009) 47-57] (DOI:10.1016/j.brainres.2009.06.081) Brain Research. 1295: 230. DOI: 10.1016/j.brainres.2009.08.027  1
2008 Borders AS, de Almeida L, Van Eldik LJ, Watterson DM. The p38alpha mitogen-activated protein kinase as a central nervous system drug discovery target. Bmc Neuroscience. 9: S12. PMID 19090985 DOI: 10.1186/1471-2202-9-S2-S12  1
2008 Thompson WL, Karpus WJ, Van Eldik LJ. MCP-1-deficient mice show reduced neuroinflammatory responses and increased peripheral inflammatory responses to peripheral endotoxin insult. Journal of Neuroinflammation. 5: 35. PMID 18706086 DOI: 10.1186/1742-2094-5-35  1
2008 Karpus WJ, Reynolds N, Behanna HA, Van Eldik LJ, Watterson DM. Inhibition of experimental autoimmune encephalomyelitis by a novel small molecular weight proinflammatory cytokine suppressing drug. Journal of Neuroimmunology. 203: 73-8. PMID 18678415 DOI: 10.1016/j.jneuroim.2008.06.039  1
2008 Fuller AD, Van Eldik LJ. MFG-E8 regulates microglial phagocytosis of apoptotic neurons. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 3: 246-56. PMID 18670887 DOI: 10.1007/s11481-008-9118-2  1
2008 Lloyd E, Somera-Molina K, Van Eldik LJ, Watterson DM, Wainwright MS. Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury. Journal of Neuroinflammation. 5: 28. PMID 18590543 DOI: 10.1186/1742-2094-5-28  1
2007 Munoz L, Ralay Ranaivo H, Roy SM, Hu W, Craft JM, McNamara LK, Chico LW, Van Eldik LJ, Watterson DM. A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model. Journal of Neuroinflammation. 4: 21. PMID 17784957 DOI: 10.1186/1742-2094-4-21  1
2007 Van Eldik LJ, Thompson WL, Ralay Ranaivo H, Behanna HA, Martin Watterson D. Glia proinflammatory cytokine upregulation as a therapeutic target for neurodegenerative diseases: function-based and target-based discovery approaches. International Review of Neurobiology. 82: 277-96. PMID 17678967 DOI: 10.1016/S0074-7742(07)82015-0  1
2007 Somera-Molina KC, Robin B, Somera CA, Anderson C, Stine C, Koh S, Behanna HA, Van Eldik LJ, Watterson DM, Wainwright MS. Glial activation links early-life seizures and long-term neurologic dysfunction: evidence using a small molecule inhibitor of proinflammatory cytokine upregulation. Epilepsia. 48: 1785-800. PMID 17521344 DOI: 10.1111/j.1528-1167.2007.01135.x  1
2007 Hu W, Ralay Ranaivo H, Roy SM, Behanna HA, Wing LK, Munoz L, Guo L, Van Eldik LJ, Watterson DM. Development of a novel therapeutic suppressor of brain proinflammatory cytokine up-regulation that attenuates synaptic dysfunction and behavioral deficits. Bioorganic & Medicinal Chemistry Letters. 17: 414-8. PMID 17079143 DOI: 10.1016/j.bmcl.2006.10.028  1
2006 Oakley H, Cole SL, Logan S, Maus E, Shao P, Craft J, Guillozet-Bongaarts A, Ohno M, Disterhoft J, Van Eldik L, Berry R, Vassar R. Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 10129-40. PMID 17021169 DOI: 10.1523/JNEUROSCI.1202-06.2006  1
2006 Wing LK, Behanna HA, Van Eldik LJ, Watterson DM, Ralay Ranaivo H. De novo and molecular target-independent discovery of orally bioavailable lead compounds for neurological disorders. Current Alzheimer Research. 3: 205-14. PMID 16842097 DOI: 10.2174/156720506777632844  1
2006 Ralay Ranaivo H, Craft JM, Hu W, Guo L, Wing LK, Van Eldik LJ, Watterson DM. Glia as a therapeutic target: selective suppression of human amyloid-beta-induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 662-70. PMID 16407564 DOI: 10.1523/JNEUROSCI.4652-05.2006  1
2006 Craft JM, Watterson DM, Van Eldik LJ. Human amyloid beta-induced neuroinflammation is an early event in neurodegeneration. Glia. 53: 484-90. PMID 16369931 DOI: 10.1002/glia.20306  1
2005 Craft JM, Watterson DM, Van Eldik LJ. Neuroinflammation: a potential therapeutic target. Expert Opinion On Therapeutic Targets. 9: 887-900. PMID 16185146 DOI: 10.1517/14728222.9.5.887  1
2005 Clayburgh DR, Barrett TA, Tang Y, Meddings JB, Van Eldik LJ, Watterson DM, Clarke LL, Mrsny RJ, Turner JR. Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo. The Journal of Clinical Investigation. 115: 2702-15. PMID 16184195 DOI: 10.1172/JCI24970  1
2005 Hu W, Ralay Ranaivo H, Craft JM, Van Eldik LJ, Watterson DM. Validation of the neuroinflammation cycle as a drug discovery target using integrative chemical biology and lead compound development with an Alzheimer's disease-related mouse model. Current Alzheimer Research. 2: 197-205. PMID 15974919 DOI: 10.2174/1567205053585828  1
2005 Craft JM, Watterson DM, Hirsch E, Van Eldik LJ. Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human beta-amyloid. Journal of Neuroinflammation. 2: 15. PMID 15967035 DOI: 10.1186/1742-2094-2-15  1
2005 Craft JM, Watterson DM, Marks A, Van Eldik LJ. Enhanced susceptibility of S-100B transgenic mice to neuroinflammation and neuronal dysfunction induced by intracerebroventricular infusion of human beta-amyloid. Glia. 51: 209-16. PMID 15810011 DOI: 10.1002/glia.20194  1
2005 White JA, Manelli AM, Holmberg KH, Van Eldik LJ, Ladu MJ. Differential effects of oligomeric and fibrillar amyloid-beta 1-42 on astrocyte-mediated inflammation. Neurobiology of Disease. 18: 459-65. PMID 15755672 DOI: 10.1016/j.nbd.2004.12.013  1
2005 Liu L, Li Y, Van Eldik LJ, Griffin WS, Barger SW. S100B-induced microglial and neuronal IL-1 expression is mediated by cell type-specific transcription factors. Journal of Neurochemistry. 92: 546-53. PMID 15659225 DOI: 10.1111/j.1471-4159.2004.02909.x  1
2004 Craft JM, Watterson DM, Frautschy SA, Van Eldik LJ. Aminopyridazines inhibit beta-amyloid-induced glial activation and neuronal damage in vivo. Neurobiology of Aging. 25: 1283-92. PMID 15465624 DOI: 10.1016/j.neurobiolaging.2004.01.006  0.56
2004 Craft JM, Van Eldik LJ, Zasadzki M, Hu W, Watterson DM. Aminopyridazines attenuate hippocampus-dependent behavioral deficits induced by human beta-amyloid in a murine model of neuroinflammation. Journal of Molecular Neuroscience : Mn. 24: 115-22. PMID 15314259 DOI: 10.1385/JMN:24:1:115  1
2004 Kudryashov DS, Stepanova OV, Vilitkevich EL, Nikonenko TA, Nadezhdina ES, Shanina NA, Lukas TJ, Van Eldik LJ, Watterson DM, Shirinsky VP. Myosin light chain kinase (210 kDa) is a potential cytoskeleton integrator through its unique N-terminal domain. Experimental Cell Research. 298: 407-17. PMID 15265689 DOI: 10.1016/j.yexcr.2004.04.025  1
2004 Wainwright MS, Craft JM, Griffin WS, Marks A, Pineda J, Padgett KR, Van Eldik LJ. Increased susceptibility of S100B transgenic mice to perinatal hypoxia-ischemia. Annals of Neurology. 56: 61-7. PMID 15236402 DOI: 10.1002/ana.20142  1
2004 Manelli AM, Stine WB, Van Eldik LJ, LaDu MJ. ApoE and Abeta1-42 interactions: effects of isoform and conformation on structure and function. Journal of Molecular Neuroscience : Mn. 23: 235-46. PMID 15181252 DOI: 10.1385/JMN:23:3:235  1
2004 Guo L, LaDu MJ, Van Eldik LJ. A dual role for apolipoprotein e in neuroinflammation: anti- and pro-inflammatory activity. Journal of Molecular Neuroscience : Mn. 23: 205-12. PMID 15181248 DOI: 10.1385/JMN:23:3:205  1
2004 Kim SH, Smith CJ, Van Eldik LJ. Importance of MAPK pathways for microglial pro-inflammatory cytokine IL-1 beta production. Neurobiology of Aging. 25: 431-9. PMID 15013563 DOI: 10.1016/S0197-4580(03)00126-X  1
2004 Xie Z, Smith CJ, Van Eldik LJ. Activated glia induce neuron death via MAP kinase signaling pathways involving JNK and p38. Glia. 45: 170-9. PMID 14730710 DOI: 10.1002/glia.10314  1
2003 Van Eldik LJ, Wainwright MS. The Janus face of glial-derived S100B: beneficial and detrimental functions in the brain. Restorative Neurology and Neuroscience. 21: 97-108. PMID 14530573  1
2003 Watterson DM, Velentza AV, Zasadzki M, Craft JM, Haiech J, Van Eldik LJ. Discovery of a new class of synthetic protein kinase inhibitors that suppress selective aspects of glial activation and protect against beta-amyloid induced injury: a foundation for future medicinal chemistry efforts focused on targeting Alzheimer's disease progression. Journal of Molecular Neuroscience : Mn. 20: 411-23. PMID 14501026 DOI: 10.1385/JMN:20:3:411  1
2003 Wainwright MS, Rossi J, Schavocky J, Crawford S, Steinhorn D, Velentza AV, Zasadzki M, Shirinsky V, Jia Y, Haiech J, Van Eldik LJ, Watterson DM. Protein kinase involved in lung injury susceptibility: evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment. Proceedings of the National Academy of Sciences of the United States of America. 100: 6233-8. PMID 12730364 DOI: 10.1073/pnas.1031595100  1
2003 Tsoporis JN, Marks A, Van Eldik LJ, O'Hanlon D, Parker TG. Regulation of the S100B gene by alpha 1-adrenergic stimulation in cardiac myocytes. American Journal of Physiology. Heart and Circulatory Physiology. 284: H193-203. PMID 12388300 DOI: 10.1152/ajpheart.00161.2002  1
2002 Watterson DM, Haiech J, Van Eldik LJ. Discovery of new chemical classes of synthetic ligands that suppress neuroinflammatory responses. Journal of Molecular Neuroscience : Mn. 19: 89-93. PMID 12212800 DOI: 10.1007/s12031-002-0016-4  1
2002 Van Eldik LJ. Structure and enzymology of a death-associated protein kinase. Trends in Pharmacological Sciences. 23: 302-4. PMID 12119143 DOI: 10.1016/S0165-6147(02)02049-7  1
2002 Van Eldik LJ, Koppal T, Watterson DM. Barriers to Alzheimer disease drug discovery and development in academia. Alzheimer Disease and Associated Disorders. 16: S18-28. PMID 12070358  1
2002 Fillit HM, O'Connell AW, Brown WM, Altstiel LD, Anand R, Collins K, Ferris SH, Khachaturian ZS, Kinoshita J, Van Eldik L, Dewey CF. Barriers to drug discovery and development for Alzheimer disease. Alzheimer Disease and Associated Disorders. 16: S1-8. PMID 12070355  1
2002 McClintock KA, Van Eldik LJ, Shaw GS. The C-terminus and linker region of S100B exert dual control on protein-protein interactions with TRTK-12. Biochemistry. 41: 5421-8. PMID 11969402 DOI: 10.1021/bi011732m  1
2002 Mirzoeva S, Sawkar A, Zasadzki M, Guo L, Velentza AV, Dunlap V, Bourguignon JJ, Ramstrom H, Haiech J, Van Eldik LJ, Watterson DM. Discovery of a 3-amino-6-phenyl-pyridazine derivative as a new synthetic antineuroinflammatory compound. Journal of Medicinal Chemistry. 45: 563-6. PMID 11806708 DOI: 10.1021/jm015573g  1
2001 Guo L, Sawkar A, Zasadzki M, Watterson DM, Van Eldik LJ. Similar activation of glial cultures from different rat brain regions by neuroinflammatory stimuli and downregulation of the activation by a new class of small molecule ligands. Neurobiology of Aging. 22: 975-81. PMID 11755006 DOI: 10.1016/S0197-4580(01)00295-0  1
2001 Lam AG, Koppal T, Akama KT, Guo L, Craft JM, Samy B, Schavocky JP, Watterson DM, Van Eldik LJ. Mechanism of glial activation by S100B: involvement of the transcription factor NFkappaB. Neurobiology of Aging. 22: 765-72. PMID 11705636 DOI: 10.1016/S0197-4580(01)00233-0  1
2001 Watterson DM, Mirzoeva S, Guo L, Whyte A, Bourguignon JJ, Hibert M, Haiech J, Van Eldik LJ. Ligand modulation of glial activation: cell permeable, small molecule inhibitors of serine-threonine protein kinases can block induction of interleukin 1 beta and nitric oxide synthase II. Neurochemistry International. 39: 459-68. PMID 11578781 DOI: 10.1016/S0197-0186(01)00053-5  1
2001 LaDu MJ, Shah JA, Reardon CA, Getz GS, Bu G, Hu J, Guo L, Van Eldik LJ. Apolipoprotein E and apolipoprotein E receptors modulate A beta-induced glial neuroinflammatory responses. Neurochemistry International. 39: 427-34. PMID 11578778 DOI: 10.1016/S0197-0186(01)00050-X  1
2001 Peskind ER, Griffin WS, Akama KT, Raskind MA, Van Eldik LJ. Cerebrospinal fluid S100B is elevated in the earlier stages of Alzheimer's disease. Neurochemistry International. 39: 409-13. PMID 11578776 DOI: 10.1016/S0197-0186(01)00048-1  1
2001 Koppal T, Lam AG, Guo L, Van Eldik LJ. S100B proteins that lack one or both cysteine residues can induce inflammatory responses in astrocytes and microglia. Neurochemistry International. 39: 401-7. PMID 11578775 DOI: 10.1016/S0197-0186(01)00047-X  1
2001 Sheng JG, Jones RA, Zhou XQ, McGinness JM, Van Eldik LJ, Mrak RE, Griffin WS. Interleukin-1 promotion of MAPK-p38 overexpression in experimental animals and in Alzheimer's disease: potential significance for tau protein phosphorylation. Neurochemistry International. 39: 341-8. PMID 11578769 DOI: 10.1016/S0197-0186(01)00041-9  1
2001 Van Eldik LJ. Glia and Alzheimer's disease. Neurochemistry International. 39: 329-31. PMID 11578767 DOI: 10.1016/S0197-0186(01)00039-0  1
2001 Engelhard HH, Duncan HA, Kim S, Criswell PS, Van Eldik L. Therapeutic effects of sodium butyrate on glioma cells in vitro and in the rat C6 glioma model Neurosurgery. 48: 616-625. PMID 11270553 DOI: 10.1097/00006123-200103000-00035  1
2000 LaDu MJ, Shah JA, Reardon CA, Getz GS, Bu G, Hu J, Guo L, van Eldik LJ. Apolipoprotein E receptors mediate the effects of beta-amyloid on astrocyte cultures. The Journal of Biological Chemistry. 275: 33974-80. PMID 10940295 DOI: 10.1074/jbc.M000602200  1
2000 Koppal T, Petrova TV, Van Eldik LJ. Cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J(2) acts as a general inhibitor of inflammatory responses in activated BV-2 microglial cells. Brain Research. 867: 115-21. PMID 10837804 DOI: 10.1016/S0006-8993(00)02270-8  1
2000 Ladu MJ, Reardon C, Van Eldik L, Fagan AM, Bu G, Holtzman D, Getz GS. Lipoproteins in the central nervous system. Annals of the New York Academy of Sciences. 903: 167-75. PMID 10818504  1
2000 Akama KT, Van Eldik LJ. Beta-amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1beta- and tumor necrosis factor-alpha (TNFalpha)-dependent, and involves a TNFalpha receptor-associated factor- and NFkappaB-inducing kinase-dependent signaling mechanism. The Journal of Biological Chemistry. 275: 7918-24. PMID 10713108 DOI: 10.1074/jbc.275.11.7918  1
2000 Matsui Lee IS, Suzuki M, Hayashi N, Hu J, Van Eldik LJ, Titani K, Nishikimi M. Copper-dependent formation of disulfide-linked dimer of S100B protein. Archives of Biochemistry and Biophysics. 374: 137-41. PMID 10666291 DOI: 10.1006/abbi.1999.1595  1
2000 Petrova TV, Hu J, Van Eldik LJ. Modulation of glial activation by astrocyte-derived protein S100B: differential responses of astrocyte and microglial cultures. Brain Research. 853: 74-80. PMID 10627310 DOI: 10.1016/S0006-8993(99)02251-9  1
1999 Kudryashov DS, Chibalina MV, Birukov KG, Lukas TJ, Sellers JR, Van Eldik LJ, Watterson DM, Shirinsky VP. Unique sequence of a high molecular weight myosin light chain kinase is involved in interaction with actin cytoskeleton. Febs Letters. 463: 67-71. PMID 10601640 DOI: 10.1016/S0014-5793(99)01591-4  1
1999 Watterson DM, Schavocky JP, Guo L, Weiss C, Chlenski A, Shirinsky VP, Van Eldik LJ, Haiech J. Analysis of the kinase-related protein gene found at human chromosome 3q21 in a multi-gene cluster: organization, expression, alternative splicing, and polymorphic marker. Journal of Cellular Biochemistry. 75: 481-91. PMID 10536370 DOI: 10.1002/(SICI)1097-4644(19991201)75:3<481::AID-JCB12>3.0.CO;2-5  1
1999 Mirzoeva S, Koppal T, Petrova TV, Lukas TJ, Watterson DM, Van Eldik LJ. Screening in a cell-based assay for inhibitors of microglial nitric oxide production reveals calmodulin-regulated protein kinases as potential drug discovery targets. Brain Research. 844: 126-34. PMID 10536268 DOI: 10.1016/S0006-8993(99)01911-3  1
1999 Hu J, Van Eldik LJ. Glial-derived proteins activate cultured astrocytes and enhance beta amyloid-induced glial activation. Brain Research. 842: 46-54. PMID 10526094 DOI: 10.1016/S0006-8993(99)01804-1  1
1999 Petrova TV, Akama KT, Van Eldik LJ. Selective modulation of BV-2 microglial activation by prostaglandin E(2). Differential effects on endotoxin-stimulated cytokine induction. The Journal of Biological Chemistry. 274: 28823-7. PMID 10497256 DOI: 10.1074/jbc.274.40.28823  1
1999 Petrova TV, Akama KT, Van Eldik LJ. Cyclopentenone prostaglandins suppress activation of microglia: down-regulation of inducible nitric-oxide synthase by 15-deoxy-Delta12,14-prostaglandin J2. Proceedings of the National Academy of Sciences of the United States of America. 96: 4668-73. PMID 10200320 DOI: 10.1073/pnas.96.8.4668  1
1998 McAdory BS, Van Eldik LJ, Norden JJ. S100B, a neurotropic protein that modulates neuronal protein phosphorylation, is upregulated during lesion-induced collateral sprouting and reactive synaptogenesis. Brain Research. 813: 211-7. PMID 9824701 DOI: 10.1016/S0006-8993(98)01014-2  1
1998 Hu J, LaDu MJ, Van Eldik LJ. Apolipoprotein E attenuates beta-amyloid-induced astrocyte activation. Journal of Neurochemistry. 71: 1626-34. PMID 9751196  1
1998 Li Y, Wang J, Sheng JG, Liu L, Barger SW, Jones RA, Van Eldik LJ, Mrak RE, Griffin WS. S100 beta increases levels of beta-amyloid precursor protein and its encoding mRNA in rat neuronal cultures. Journal of Neurochemistry. 71: 1421-8. PMID 9751173  1
1998 Birukov KG, Schavocky JP, Shirinsky VP, Chibalina MV, Van Eldik LJ, Watterson DM. Organization of the genetic locus for chicken myosin light chain kinase is complex: multiple proteins are encoded and exhibit differential expression and localization. Journal of Cellular Biochemistry. 70: 402-13. PMID 9706877 DOI: 10.1002/(SICI)1097-4644(19980901)70:3<402::AID-JCB13>3.0.CO;2-M  1
1998 Haridas V, Ni J, Meager A, Su J, Yu GL, Zhai Y, Kyaw H, Akama KT, Hu J, Van Eldik LJ, Aggarwal BB. TRANK, a novel cytokine that activates NF-kappa B and c-Jun N-terminal kinase. Journal of Immunology (Baltimore, Md. : 1950). 161: 1-6. PMID 9647199  1
1998 Akama KT, Albanese C, Pestell RG, Van Eldik LJ. Amyloid beta-peptide stimulates nitric oxide production in astrocytes through an NFkappaB-dependent mechanism. Proceedings of the National Academy of Sciences of the United States of America. 95: 5795-800. PMID 9576964 DOI: 10.1073/pnas.95.10.5795  1
1998 LaDu MJ, Gilligan SM, Lukens JR, Cabana VG, Reardon CA, Van Eldik LJ, Holtzman DM. Nascent astrocyte particles differ from lipoproteins in CSF. Journal of Neurochemistry. 70: 2070-81. PMID 9572293  1
1998 Hu J, Akama KT, Krafft GA, Chromy BA, Van Eldik LJ. Amyloid-beta peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release. Brain Research. 785: 195-206. PMID 9518610 DOI: 10.1016/S0006-8993(97)01318-8  1
1997 Durussel I, Van Eldik LJ, Cox JA. Ion-binding properties of recombinant S100beta and two derivatives with either an inactivated Ca2+ site II or a normalized Ca2+ site I. Biochimica Et Biophysica Acta. 1343: 139-43. PMID 9434104 DOI: 10.1016/S0167-4838(97)00106-4  1
1997 Kilby PM, Van Eldik LJ, Roberts GC. Identification of the binding site on S100B protein for the actin capping protein CapZ. Protein Science : a Publication of the Protein Society. 6: 2494-503. PMID 9416599 DOI: 10.1002/pro.5560061202  1
1997 Hu J, Ferreira A, Van Eldik LJ. S100beta induces neuronal cell death through nitric oxide release from astrocytes. Journal of Neurochemistry. 69: 2294-301. PMID 9375660  1
1997 Castets F, Griffin WS, Marks A, Van Eldik LJ. Transcriptional regulation of the human S100 beta gene. Brain Research. Molecular Brain Research. 46: 208-16. PMID 9191095 DOI: 10.1016/S0169-328X(96)00298-7  1
1996 Hu J, Van Eldik LJ. S100 beta induces apoptotic cell death in cultured astrocytes via a nitric oxide-dependent pathway. Biochimica Et Biophysica Acta. 1313: 239-45. PMID 8898860 DOI: 10.1016/0167-4889(96)00095-X  1
1996 Sheng JG, Ito K, Skinner RD, Mrak RE, Rovnaghi CR, Van Eldik LJ, Griffin WS. In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis. Neurobiology of Aging. 17: 761-6. PMID 8892349 DOI: 10.1016/0197-4580(96)00104-2  1
1996 Kilby PM, Van Eldik LJ, Roberts GC. The solution structure of the bovine S100B protein dimer in the calcium-free state. Structure (London, England : 1993). 4: 1041-52. PMID 8805590 DOI: 10.1016/S0969-2126(96)00111-6  1
1996 Sheng JG, Mrak RE, Rovnaghi CR, Kozlowska E, Van Eldik LJ, Griffin WS. Human brain S100 beta and S100 beta mRNA expression increases with age: pathogenic implications for Alzheimer's disease. Neurobiology of Aging. 17: 359-63. PMID 8725896 DOI: 10.1016/0197-4580(96)00037-1  1
1996 Van Eldik LJ. Chapter 8 Antisense RNA and DNA as potential therapeutic agents Principles of Medical Biology. 5: 149-162. DOI: 10.1016/S1569-2582(96)80112-7  1
1995 Griffin WS, Yeralan O, Sheng JG, Boop FA, Mrak RE, Rovnaghi CR, Burnett BA, Feoktistova A, Van Eldik LJ. Overexpression of the neurotrophic cytokine S100 beta in human temporal lobe epilepsy. Journal of Neurochemistry. 65: 228-33. PMID 7790864  1
1995 Kilby PM, Van Eldik LJ, Roberts GC. Nuclear magnetic resonance assignments and secondary structure of bovine S100 beta protein. Febs Letters. 363: 90-6. PMID 7729560 DOI: 10.1016/0014-5793(95)00296-L  1
1995 Barger SW, Van Eldik LJ, Mattson MP. S100 beta protects hippocampal neurons from damage induced by glucose deprivation. Brain Research. 677: 167-70. PMID 7606463 DOI: 10.1016/0006-8993(95)00160-R  1
1995 Watterson DM, Collinge M, Lukas TJ, Van Eldik LJ, Birukov KG, Stepanova OV, Shirinsky VP. Multiple gene products are produced from a novel protein kinase transcription region. Febs Letters. 373: 217-20. PMID 7589469 DOI: 10.1016/0014-5793(95)01048-J  1
1995 Krebs J, Quadroni M, Van Eldik LJ. Dance of the dimers. Nature Structural Biology. 2: 711-4. PMID 7552735  1
1994 Van Eldik LJ, Griffin WS. S100 beta expression in Alzheimer's disease: relation to neuropathology in brain regions. Biochimica Et Biophysica Acta. 1223: 398-403. PMID 7918676 DOI: 10.1016/0167-4889(94)90101-5  1
1994 Pochet R, Van Rampelbergh J, Bastianelli E, Van Eldik LJ. Calmodulin, calbindin-D28K and calretinin in rat and chicken pineal glands: immunocytochemical and immunoblotting analysis. Biochimica Et Biophysica Acta. 1223: 318-24. PMID 7918665 DOI: 10.1016/0167-4889(94)90090-6  1
1994 Lin LH, Van Eldik LJ, Osheroff N, Norden JJ. Inhibition of protein kinase C- and casein kinase II-mediated phosphorylation of GAP-43 by S100 beta. Brain Research. Molecular Brain Research. 25: 297-304. PMID 7808229 DOI: 10.1016/0169-328X(94)90165-1  1
1993 Dyck RH, Van Eldik LJ, Cynader MS. Immunohistochemical localization of the S-100 beta protein in postnatal cat visual cortex: spatial and temporal patterns of expression in cortical and subcortical glia. Brain Research. Developmental Brain Research. 72: 181-92. PMID 8485842 DOI: 10.1016/0165-3806(93)90183-B  1
1993 Kan-Mitchell J, Liggett PE, Taylor CR, Rao N, Granada ES, Danenberg KD, White WL, Van Eldik LJ, Horikoshi T, Danenberg PV. Differential S100 beta expression in choroidal and skin melanomas: quantitation by the polymerase chain reaction. Investigative Ophthalmology & Visual Science. 34: 3366-75. PMID 8225871  1
1992 Barger SW, Wolchok SR, Van Eldik LJ. Disulfide-linked S100 beta dimers and signal transduction. Biochimica Et Biophysica Acta. 1160: 105-12. PMID 1420327 DOI: 10.1016/0167-4838(92)90043-D  1
1992 Collinge M, Matrisian PE, Zimmer WE, Shattuck RL, Lukas TJ, Van Eldik LJ, Watterson DM. Structure and expression of a calcium-binding protein gene contained within a calmodulin-regulated protein kinase gene. Molecular and Cellular Biology. 12: 2359-71. PMID 1373815  1
1992 Van Eldik LJ, Barger SW, Welsh MJ. Antisense approaches to the function of glial cell proteins. Annals of the New York Academy of Sciences. 660: 219-30. PMID 1340124 DOI: 10.1111/j.1749-6632.1992.tb21074.x  1
1992 Barger SW, Van Eldik LJ. S100 beta stimulates calcium fluxes in glial and neuronal cells. The Journal of Biological Chemistry. 267: 9689-94. PMID 1315768  1
1992 Azmitia EC, Griffin WS, Marshak DR, Van Eldik LJ, Whitaker-Azmitia PM. S100 beta and serotonin: a possible astrocytic-neuronal link to neuropathology of Alzheimer's disease. Progress in Brain Research. 94: 459-73. PMID 1287730  1
1991 Van Eldik LJ, Christie-Pope B, Bolin LM, Shooter EM, Whetsell WO. Neurotrophic activity of S-100 beta in cultures of dorsal root ganglia from embryonic chick and fetal rat. Brain Research. 542: 280-5. PMID 2029635 DOI: 10.1016/0006-8993(91)91579-P  1
1991 Selinfreund RH, Barger SW, Pledger WJ, Van Eldik LJ. Neurotrophic protein S100 beta stimulates glial cell proliferation. Proceedings of the National Academy of Sciences of the United States of America. 88: 3554-8. PMID 1902567  1
1991 De León M, Van Eldik LJ, Shooter EM. Differential regulation of S100 beta and mRNAs coding for S100-like proteins (42A and 42C) during development and after lesion of rat sciatic nerve. Journal of Neuroscience Research. 29: 155-62. PMID 1890696 DOI: 10.1002/jnr.490290204  1
1991 Pochet R, Pasteels B, Seto-Ohshima A, Bastianelli E, Kitajima S, Van Eldik LJ. Calmodulin and calbindin localization in retina from six vertebrate species. The Journal of Comparative Neurology. 314: 750-62. PMID 1816273 DOI: 10.1002/cne.903140408  1
1991 Kahn HJ, Baumal R, Van Eldik LJ, Dunn RJ, Marks A. Immunoreactivity of S100 beta in heart, skeletal muscle, and kidney in chronic lung disease: possible induction by cAMP. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. 4: 698-701. PMID 1664955  1
1990 Selinfreund RH, Barger SW, Welsh MJ, Van Eldik LJ. Antisense inhibition of glial S100 beta production results in alterations in cell morphology, cytoskeletal organization, and cell proliferation. The Journal of Cell Biology. 111: 2021-8. PMID 2229184  1
1990 Jiang K, Zheng J, Higgins SB, Watterson DM, Craig TA, Lukas TJ, Van Eldik LJ. A knowledge-based experimental design system for nucleic acid engineering. Computer Applications in the Biosciences : Cabios. 6: 205-12. PMID 2207744 DOI: 10.1093/bioinformatics/6.3.205  1
1990 Shoemaker MO, Lau W, Shattuck RL, Kwiatkowski AP, Matrisian PE, Guerra-Santos L, Wilson E, Lukas TJ, Van Eldik LJ, Watterson DM. Use of DNA sequence and mutant analyses and antisense oligodeoxynucleotides to examine the molecular basis of nonmuscle myosin light chain kinase autoinhibition, calmodulin recognition, and activity. The Journal of Cell Biology. 111: 1107-25. PMID 2202734  1
1990 Van Eldik LJ, Zimmer WE, Barger SW, Watterson DM. Perturbation of the calmodulin system in transformed cells. Advances in Experimental Medicine and Biology. 269: 111-20. PMID 2162134  1
1990 Kan-Mitchell J, Rao N, Albert DM, Van Eldik LJ, Taylor CR. S100 immunophenotypes of uveal melanomas. Investigative Ophthalmology & Visual Science. 31: 1492-6. PMID 1696942  1
1989 Zimmer DB, Van Eldik LJ. Analysis of the calcium-modulated proteins, S100 and calmodulin, and their target proteins during C6 glioma cell differentiation. The Journal of Cell Biology. 108: 141-51. PMID 2910876  1
1989 Winningham-Major F, Staecker JL, Barger SW, Coats S, Van Eldik LJ. Neurite extension and neuronal survival activities of recombinant S100 beta proteins that differ in the content and position of cysteine residues. The Journal of Cell Biology. 109: 3063-71. PMID 2592414 DOI: 10.1083/jcb.109.6.3063  1
1988 Van Eldik LJ, Staecker JL, Winningham-Major F. Synthesis and expression of a gene coding for the calcium-modulated protein S100 beta and designed for cassette-based, site-directed mutagenesis. The Journal of Biological Chemistry. 263: 7830-7. PMID 3372506  1
1988 Zimmer DB, Van Eldik LJ. Levels and distribution of the calcium-modulated proteins S100 and calmodulin in rat C6 glioma cells. Journal of Neurochemistry. 50: 572-9. PMID 3275741  1
1988 Van Eldik LJ, Zimmer DB. Approaches to study the role of S100 proteins in calcium-dependent cellular responses. Journal of Dairy Science. 71: 2028-34. PMID 3170862 DOI: 10.3168/jds.S0022-0302(88)79778-7  1
1987 Zimmer DB, Van Eldik LJ. Tissue distribution of rat S100 alpha and S100 beta and S100-binding proteins. The American Journal of Physiology. 252: C285-9. PMID 3826357  1
1987 Hertzberg EL, Van Eldik LJ. Interaction of calmodulin and other calcium-modulated proteins with gap junctions. Methods in Enzymology. 139: 445-54. PMID 3587034 DOI: 10.1016/0076-6879(87)39105-0  1
1987 Van Eldik LJ, Zimmer DB. Secretion of S-100 from rat C6 glioma cells. Brain Research. 436: 367-70. PMID 3435834 DOI: 10.1016/0006-8993(87)91681-7  1
1987 Van Eldik LJ, Lukas TJ. Site-directed antibodies to vertebrate and plant calmodulins. Methods in Enzymology. 139: 393-405. PMID 2438535  0.64
1987 Van Eldik LJ, Lukas TJ. [32]Site-directed antibodies to vertebrate and plant calmodulins Methods in Enzymology. 139: 393-405. DOI: 10.1016/0076-6879(87)39101-3  1
1986 Van Eldik LJ, Jensen RA, Ehrenfried BA, Whetsell WO. Immunohistochemical localization of S100 beta in human nervous system tumors by using monoclonal antibodies with specificity for the S100 beta polypeptide. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 34: 977-82. PMID 3734419  1
1986 Zimmer DB, Van Eldik LJ. Identification of a molecular target for the calcium-modulated protein S100. Fructose-1,6-bisphosphate aldolase. The Journal of Biological Chemistry. 261: 11424-8. PMID 3733759  1
1985 Van Eldik LJ, Hertzberg EL, Berdan RC, Gilula NB. Interaction of calmodulin and other calcium-modulated proteins with mammalian and arthropod junctional membrane proteins. Biochemical and Biophysical Research Communications. 126: 825-32. PMID 2983692 DOI: 10.1016/0006-291X(85)90259-1  1
1985 Vantard M, Lambert AM, De Mey J, Picquot P, Van Eldik LJ. Characterization and immunocytochemical distribution of calmodulin in higher plant endosperm cells: localization in the mitotic apparatus. The Journal of Cell Biology. 101: 488-99. PMID 2410433  1
1985 Van Eldik LJ, Lukas TJ, Watterson DM. Engineering of site-directed antibodies against plant calmodulin Federation Proceedings. 44: No. 1839.  1
1985 Noland TD, Van Eldik LJ, Garbers DL, Burgess WH. Distribution of calmodulin and calmodulin-binding proteins in membranes from bovine epididymal spermatozoa Gamete Research. 11: 297-303.  1
1984 Van Eldik LJ, Wolchok SR. Conditions for reproducible detection of calmodulin and S100 beta in immunoblots. Biochemical and Biophysical Research Communications. 124: 752-9. PMID 6391480 DOI: 10.1016/0006-291X(84)91022-2  1
1984 Van Eldik LJ, Watterson DM, Burgess WH. Immunoreactive levels of myosin light-chain kinase in normal and virus-transformed chicken embryo fibroblasts. Molecular and Cellular Biology. 4: 2224-6. PMID 6390185  1
1984 Christakos S, Bruns ME, Mehra AS, Rhoten WB, Van Eldik LJ. Calmodulin and rat vitamin D-dependent calcium-binding proteins: biochemical and immunochemical comparison. Archives of Biochemistry and Biophysics. 231: 38-47. PMID 6326677 DOI: 10.1016/0003-9861(84)90360-6  1
1984 Watterson DM, Burgess WH, Lukas TJ, Iverson D, Marshak DR, Schleicher M, Erickson BW, Fok KF, Van Eldik LJ. Towards a molecular and atomic anatomy of calmodulin and calmodulin-binding proteins. Advances in Cyclic Nucleotide and Protein Phosphorylation Research. 16: 205-26. PMID 6326525  1
1984 Van Eldik LJ, Ehrenfried B, Jensen RA. Production and characterization of monoclonal antibodies with specificity for the S100 beta polypeptide of brain S100 fractions. Proceedings of the National Academy of Sciences of the United States of America. 81: 6034-8. PMID 6207537  1
1984 Zendegui JG, Zielinski RE, Watterson DM, Van Eldik LJ. Biosynthesis of calmodulin in normal and virus-transformed chicken embryo fibroblasts. Molecular and Cellular Biology. 4: 883-9. PMID 6203028  1
1984 Burgess WH, Watterson DM, Van Eldik LJ. Identification of calmodulin-binding proteins in chicken embryo fibroblasts. The Journal of Cell Biology. 99: 550-7. PMID 6086671  1
1983 Van Eldik LJ, Burgess WH. Analytical subcellular distribution of calmodulin and calmodulin-binding proteins in normal and virus-transformed fibroblasts. The Journal of Biological Chemistry. 258: 4539-47. PMID 6833267  1
1983 Van Eldik LJ, Watterson DM, Fok KF, Erickson BW. Elucidation of a minimal immunoreactive site of vertebrate calmodulin. Archives of Biochemistry and Biophysics. 227: 522-33. PMID 6667029 DOI: 10.1016/0003-9861(83)90481-2  1
1983 Van Eldik LJ, Fok KF, Erickson BW, Watterson DM. Engineering of site-directed antisera against vertebrate calmodulin by using synthetic peptide immunogens containing an immunoreactive site. Proceedings of the National Academy of Sciences of the United States of America. 80: 6775-9. PMID 6196776  1
1982 Van Eldik LJ, Zendegui JG, Marshak DR, Watterson DM. Calcium-binding proteins and the molecular basis of calcium action. International Review of Cytology. 77: 1-61. PMID 6757171  1
1981 Marshak DR, Watterson DM, Van Eldik LJ. Calcium-dependent interaction of S100b, troponin C, and calmodulin with an immobilized phenothiazine. Proceedings of the National Academy of Sciences of the United States of America. 78: 6793-7. PMID 6947252  1
1981 Van Eldik LJ, Watterson DM. Reproducible production of antiserum against vertebrate calmodulin and determination of the immunoreactive site. The Journal of Biological Chemistry. 256: 4205-10. PMID 6163780  1
1980 Watterson DM, Iverson DB, Van Eldik LJ. Spinach calmodulin: isolation, characterization, and comparison with vertebrate calmodulins. Biochemistry. 19: 5762-8. PMID 7459343  1
1980 Van Eldik LJ, Watterson DM. Reproducible production and characterization of anti-calmodulin antisera. Annals of the New York Academy of Sciences. 356: 437-8. PMID 6940510 DOI: 10.1111/j.1749-6632.1980.tb29663.x  1
1980 Marshak DR, Van Eldik LJ, Watterson DM. Isolation of a protein from brain using calcium-dependent affinity-based adsorption chromatography on phenothiazine-Sepharose conjugates. Annals of the New York Academy of Sciences. 356: 410-1. PMID 6940504 DOI: 10.1111/j.1749-6632.1980.tb29651.x  1
1980 Van Eldik LJ, Piperno G, Watterson DM. Similarities and dissimilarities between calmodulin and a Chlamydomonas flagellar protein. Proceedings of the National Academy of Sciences of the United States of America. 77: 4779-83. PMID 6254039  1
1980 Watterson DM, Iverson DB, Van Eldik LJ. Rapid separation and quantitation of 3',5'-cyclic nucleotides and 5'-nucleotides in phosphodiesterase reaction mixtures using high-performance liquid chromatography. Journal of Biochemical and Biophysical Methods. 2: 139-46. PMID 6252261 DOI: 10.1016/0165-022X(80)90021-4  1
1980 Van Eldik LJ, Piperno G, Watterson DM. Comparative biochemistry of calmodulins and calmodulin-like proteins. Annals of the New York Academy of Sciences. 356: 36-42. PMID 6112948 DOI: 10.1111/j.1749-6632.1980.tb29597.x  1
1980 Van Eldik LJ, Grossman AR, Iverson DB, Watterson DM. Isolation and characterization of calmodulin from spinach leaves and in vitro translation mixtures Proceedings of the National Academy of Sciences of the United States of America. 77: 1912-1916.  1
1979 Van Eldik LJ, Watterson DM. Characterization of a calcium-modulated protein from transformed chicken fibroblasts. The Journal of Biological Chemistry. 254: 10250-5. PMID 226538  1
1978 Smith RE, Van Eldik LJ. Characterization of the immunosuppression accompanying virus-induced avian osteopetrosis. Infection and Immunity. 22: 452-61. PMID 730367  1
1978 Van Eldik LJ, Paulson JC, Green RW, Smith RE. The influence of carbohydrate on the antigenicity of the envelope glycoprotein of avian myeloblastosis virus and B77 avian sarcoma virus. Virology. 86: 193-204. PMID 208246 DOI: 10.1016/0042-6822(78)90020-X  1
1978 Van Eldik LJ, Smith RE. Isolation and characterization of the envelope glycoprotein of an avian osteopetrosis virus: effect of host cell on antigenic reactivity. Virology. 90: 80-9. PMID 82295 DOI: 10.1016/0042-6822(78)90335-5  1
1976 Watterson DM, Van Eldik LJ, Smith RE, Vanaman TC. Calcium-dependent regulatory protein of cyclic nucleotide metabolism in normal and transformed chicken embryo fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 73: 2711-5. PMID 183206  1
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