David Wynick - Publications

University of Bristol, Bristol, England, United Kingdom 
glanin, neuropeptides

63 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Holmes FE, Kerr N, Chen YJ, Vanderplank P, McArdle CA, Wynick D. Targeted disruption of the orphan receptor Gpr151 does not alter pain-related behaviour despite a strong induction in dorsal root ganglion expression in a model of neuropathic pain. Molecular and Cellular Neurosciences. PMID 27913310 DOI: 10.1016/J.Mcn.2016.11.010  0.701
2015 Kerr N, Holmes FE, Hobson SA, Vanderplank P, Leard A, Balthasar N, Wynick D. The generation of knock-in mice expressing fluorescently tagged galanin receptors 1 and 2. Molecular and Cellular Neurosciences. 68: 258-71. PMID 26292267 DOI: 10.1016/J.Mcn.2015.08.006  0.69
2015 Gresle MM, Butzkueven H, Perreau VM, Jonas A, Xiao J, Thiem S, Holmes FE, Doherty W, Soo PY, Binder MD, Akkermann R, Jokubaitis VG, Cate HS, Marriott MP, Gundlach AL, ... Wynick D, et al. Galanin is an autocrine myelin and oligodendrocyte trophic signal induced by leukemia inhibitory factor. Glia. 63: 1005-20. PMID 25639936 DOI: 10.1002/Glia.22798  0.647
2015 Lang R, Gundlach AL, Holmes FE, Hobson SA, Wynick D, Hökfelt T, Kofler B. Physiology, signaling, and pharmacology of galanin peptides and receptors: three decades of emerging diversity. Pharmacological Reviews. 67: 118-75. PMID 25428932 DOI: 10.1124/Pr.112.006536  0.661
2014 Cordero-Llana O, Rinaldi F, Brennan PA, Wynick D, Caldwell MA. Galanin promotes neuronal differentiation from neural progenitor cells in vitro and contributes to the generation of new olfactory neurons in the adult mouse brain. Experimental Neurology. 256: 93-104. PMID 24726665 DOI: 10.1016/J.Expneurol.2014.04.001  0.791
2013 Hobson SA, Vanderplank PA, Pope RJ, Kerr NC, Wynick D. Galanin stimulates neurite outgrowth from sensory neurons by inhibition of Cdc42 and Rho GTPases and activation of cofilin. Journal of Neurochemistry. 127: 199-208. PMID 23895321 DOI: 10.1111/Jnc.12379  0.461
2013 Beazley-Long N, Hua J, Jehle T, Hulse RP, Dersch R, Lehrling C, Bevan H, Qiu Y, Lagrèze WA, Wynick D, Churchill AJ, Kehoe P, Harper SJ, Bates DO, Donaldson LF. VEGF-A165b is an endogenous neuroprotective splice isoform of vascular endothelial growth factor A in vivo and in vitro. The American Journal of Pathology. 183: 918-29. PMID 23838428 DOI: 10.1016/J.Ajpath.2013.05.031  0.768
2012 Holmes FE, Vanderplank P, Wynick D. Galanin-expression and galanin-dependent sensory neurons are not required for itch. Molecular Pain. 8: 87. PMID 23216829 DOI: 10.1186/1744-8069-8-87  0.732
2012 Vilches JJ, Wynick D, Kofler B, Lang R, Navarro X. Sudomotor function and sweat gland innervation in galanin knockout mice. Neuropeptides. 46: 151-5. PMID 22698811 DOI: 10.1016/J.Npep.2012.05.002  0.403
2012 Hulse RP, Donaldson LF, Wynick D. Differential roles of galanin on mechanical and cooling responses at the primary afferent nociceptor. Molecular Pain. 8: 41. PMID 22672616 DOI: 10.1186/1744-8069-8-41  0.823
2012 Hulse RP, Donaldson LF, Wynick D. Peripheral galanin receptor 2 as a target for the modulation of pain. Pain Research and Treatment. 2012: 545386. PMID 22315681 DOI: 10.1155/2012/545386  0.814
2012 Holmes FE, Armenaki A, Iismaa TP, Einstein EB, Shine J, Picciotto MR, Wynick D, Zachariou V. Galanin negatively modulates opiate withdrawal via galanin receptor 1. Psychopharmacology. 220: 619-25. PMID 21969124 DOI: 10.1007/S00213-011-2515-X  0.664
2011 Strickland IT, Richards L, Holmes FE, Wynick D, Uney JB, Wong LF. Axotomy-induced miR-21 promotes axon growth in adult dorsal root ganglion neurons. Plos One. 6: e23423. PMID 21853131 DOI: 10.1371/Journal.Pone.0023423  0.639
2011 Hulse RP, Wynick D, Donaldson LF. Activation of the galanin receptor 2 in the periphery reverses nerve injury-induced allodynia. Molecular Pain. 7: 26. PMID 21496293 DOI: 10.1186/1744-8069-7-26  0.829
2011 Elliott-Hunt CR, Holmes FE, Hartley DM, Perez S, Mufson EJ, Wynick D. Endogenous galanin protects mouse hippocampal neurons against amyloid toxicity in vitro via activation of galanin receptor-2. Journal of Alzheimer's Disease : Jad. 25: 455-62. PMID 21471641 DOI: 10.3233/Jad-2011-110011  0.693
2011 Kelley CM, Perez SE, Overk CR, Wynick D, Mufson EJ. Effect of neocortical and hippocampal amyloid deposition upon galaninergic and cholinergic neurites in AβPPswe/PS1ΔE9 mice. Journal of Alzheimer's Disease : Jad. 25: 491-504. PMID 21471639 DOI: 10.3233/Jad-2011-102097  0.316
2010 Hobson SA, Bacon A, Elliot-Hunt CR, Holmes FE, Kerr NC, Pope R, Vanderplank P, Wynick D. Galanin acts as a trophic factor to the central and peripheral nervous systems. Exs. 102: 25-38. PMID 21299059 DOI: 10.1007/978-3-0346-0228-0_3  0.737
2010 Pope RJ, Holmes FE, Kerr NC, Wynick D. Characterisation of the nociceptive phenotype of suppressible galanin overexpressing transgenic mice. Molecular Pain. 6: 67. PMID 20964829 DOI: 10.1186/1744-8069-6-67  0.742
2010 Kerr N, Pintzas A, Holmes F, Hobson SA, Pope R, Wallace M, Wasylyk C, Wasylyk B, Wynick D. The expression of ELK transcription factors in adult DRG: Novel isoforms, antisense transcripts and upregulation by nerve damage. Molecular and Cellular Neurosciences. 44: 165-77. PMID 20304071 DOI: 10.1016/J.Mcn.2010.03.005  0.678
2010 Hulse R, Wynick D, Donaldson LF. Intact cutaneous C fibre afferent properties in mechanical and cold neuropathic allodynia. European Journal of Pain (London, England). 14: 565.e1-565.e10. PMID 19942464 DOI: 10.1016/J.Ejpain.2009.10.001  0.797
2009 Oldfield S, Hancock J, Mason A, Hobson SA, Wynick D, Kelly E, Randall AD, Marrion NV. Receptor-mediated suppression of potassium currents requires colocalization within lipid rafts. Molecular Pharmacology. 76: 1279-89. PMID 19726551 DOI: 10.1124/Mol.109.058008  0.326
2009 Wraith DC, Pope R, Butzkueven H, Holder H, Vanderplank P, Lowrey P, Day MJ, Gundlach AL, Kilpatrick TJ, Scolding N, Wynick D. A role for galanin in human and experimental inflammatory demyelination. Proceedings of the National Academy of Sciences of the United States of America. 106: 15466-71. PMID 19717462 DOI: 10.1073/Pnas.0903360106  0.452
2008 Kerr NC, Holmes FE, Wynick D. Novel mRNA isoforms of the sodium channels Na(v)1.2, Na(v)1.3 and Na(v)1.7 encode predicted two-domain, truncated proteins. Neuroscience. 155: 797-808. PMID 18675520 DOI: 10.1016/J.Neuroscience.2008.04.060  0.613
2008 Hobson SA, Bacon A, Elliot-Hunt CR, Holmes FE, Kerr NC, Pope R, Vanderplank P, Wynick D. Galanin acts as a trophic factor to the central and peripheral nervous systems. Cellular and Molecular Life Sciences : Cmls. 65: 1806-12. PMID 18500646 DOI: 10.1007/S00018-008-8154-7  0.738
2008 Hulse R, Wynick D, Donaldson LF. Characterization of a novel neuropathic pain model in mice. Neuroreport. 19: 825-9. PMID 18463495 DOI: 10.1097/Wnr.0B013E328300Ee0A  0.81
2008 Holmes FE, Arnott N, Vanderplank P, Kerr NC, Longbrake EE, Popovich PG, Imai T, Combadière C, Murphy PM, Wynick D. Intra-neural administration of fractalkine attenuates neuropathic pain-related behaviour. Journal of Neurochemistry. 106: 640-9. PMID 18410510 DOI: 10.1111/J.1471-4159.2008.05419.X  0.717
2008 Adams AC, Clapham JC, Wynick D, Speakman JR. Feeding behaviour in galanin knockout mice supports a role of galanin in fat intake and preference. Journal of Neuroendocrinology. 20: 199-206. PMID 18088361 DOI: 10.1111/J.1365-2826.2007.01638.X  0.303
2008 Schmidhuber SM, Starr A, Wynick D, Kofler B, Brain SD. Targeted disruption of the galanin gene attenuates inflammatory responses in murine skin. Journal of Molecular Neuroscience : Mn. 34: 149-55. PMID 17999197 DOI: 10.1007/S12031-007-9015-9  0.366
2008 Hawes JJ, Brunzell DH, Narasimhaiah R, Langel U, Wynick D, Picciotto MR. Galanin protects against behavioral and neurochemical correlates of opiate reward. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 1864-73. PMID 17957220 DOI: 10.1038/Sj.Npp.1301579  0.371
2007 Sachs HH, Wynick D, Zigmond RE. Galanin plays a role in the conditioning lesion effect in sensory neurons. Neuroreport. 18: 1729-33. PMID 17921877 DOI: 10.1097/Wnr.0B013E3282F0D3F4  0.397
2007 Bacon A, Kerr NC, Holmes FE, Gaston K, Wynick D. Characterization of an enhancer region of the galanin gene that directs expression to the dorsal root ganglion and confers responsiveness to axotomy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 6573-80. PMID 17567818 DOI: 10.1523/Jneurosci.1596-07.2007  0.693
2007 Kerr NC, Gao Z, Holmes FE, Hobson SA, Hancox JC, Wynick D, James AF. The sodium channel Nav1.5a is the predominant isoform expressed in adult mouse dorsal root ganglia and exhibits distinct inactivation properties from the full-length Nav1.5 channel. Molecular and Cellular Neurosciences. 35: 283-91. PMID 17433712 DOI: 10.1016/J.Mcn.2007.03.002  0.657
2007 Marsh BC, Kerr NC, Isles N, Denhardt DT, Wynick D. Osteopontin expression and function within the dorsal root ganglion. Neuroreport. 18: 153-7. PMID 17301681 DOI: 10.1097/Wnr.0B013E328010D4Fa  0.515
2007 Elliott-Hunt CR, Pope RJ, Vanderplank P, Wynick D. Activation of the galanin receptor 2 (GalR2) protects the hippocampus from neuronal damage. Journal of Neurochemistry. 100: 780-9. PMID 17263796 DOI: 10.1111/J.1471-4159.2006.04239.X  0.441
2006 Hobson SA, Holmes FE, Kerr NC, Pope RJ, Wynick D. Mice deficient for galanin receptor 2 have decreased neurite outgrowth from adult sensory neurons and impaired pain-like behaviour. Journal of Neurochemistry. 99: 1000-10. PMID 17076662 DOI: 10.1111/J.1471-4159.2006.04143.X  0.742
2005 Holmes FE, Mahoney SA, Wynick D. Use of genetically engineered transgenic mice to investigate the role of galanin in the peripheral nervous system after injury. Neuropeptides. 39: 191-9. PMID 15944011 DOI: 10.1016/J.Npep.2005.01.001  0.737
2005 Hawes JJ, Brunzell DH, Wynick D, Zachariou V, Picciotto MR. GalR1, but not GalR2 or GalR3, levels are regulated by galanin signaling in the locus coeruleus through a cyclic AMP-dependent mechanism. Journal of Neurochemistry. 93: 1168-76. PMID 15934937 DOI: 10.1111/J.1471-4159.2005.03105.X  0.421
2005 Naylor MJ, Oakes SR, Gardiner-Garden M, Harris J, Blazek K, Ho TW, Li FC, Wynick D, Walker AM, Ormandy CJ. Transcriptional changes underlying the secretory activation phase of mammary gland development. Molecular Endocrinology (Baltimore, Md.). 19: 1868-83. PMID 15705664 DOI: 10.1210/Me.2004-0254  0.346
2004 Kerr NC, Holmes FE, Wynick D. Novel isoforms of the sodium channels Nav1.8 and Nav1.5 are produced by a conserved mechanism in mouse and rat. The Journal of Biological Chemistry. 279: 24826-33. PMID 15047701 DOI: 10.1074/Jbc.M401281200  0.609
2004 Ahrén B, Pacini G, Wynick D, Wierup N, Sundler F. Loss-of-function mutation of the galanin gene is associated with perturbed islet function in mice. Endocrinology. 145: 3190-6. PMID 15044363 DOI: 10.1210/En.2003-1700  0.309
2004 Elliott-Hunt CR, Marsh B, Bacon A, Pope R, Vanderplank P, Wynick D. Galanin acts as a neuroprotective factor to the hippocampus. Proceedings of the National Academy of Sciences of the United States of America. 101: 5105-10. PMID 15041741 DOI: 10.1073/Pnas.0304823101  0.425
2004 Hohmann JG, Teklemichael DN, Weinshenker D, Wynick D, Clifton DK, Steiner RA. Obesity and endocrine dysfunction in mice with deletions of both neuropeptide Y and galanin. Molecular and Cellular Biology. 24: 2978-85. PMID 15024085 DOI: 10.1128/Mcb.24.7.2978-2985.2004  0.333
2003 Mahoney SA, Hosking R, Wynick D. The galanin antagonist M35 has intrinsic agonistic activity in the dorsal root ganglion. Neuroreport. 14: 1649-52. PMID 14502094 DOI: 10.1097/00001756-200308260-00022  0.37
2003 Zachariou V, Brunzell DH, Hawes J, Stedman DR, Bartfai T, Steiner RA, Wynick D, Langel U, Picciotto MR. The neuropeptide galanin modulates behavioral and neurochemical signs of opiate withdrawal. Proceedings of the National Academy of Sciences of the United States of America. 100: 9028-33. PMID 12853567 DOI: 10.1073/Pnas.1533224100  0.403
2003 Hohmann JG, Krasnow SM, Teklemichael DN, Clifton DK, Wynick D, Steiner RA. Neuroendocrine profiles in galanin-overexpressing and knockout mice. Neuroendocrinology. 77: 354-66. PMID 12845222 DOI: 10.1159/000071308  0.379
2003 Naylor MJ, Ginsburg E, Iismaa TP, Vonderhaar BK, Wynick D, Ormandy CJ. The neuropeptide galanin augments lobuloalveolar development. The Journal of Biological Chemistry. 278: 29145-52. PMID 12759342 DOI: 10.1074/Jbc.M303746200  0.355
2003 Holmes FE, Bacon A, Pope RJ, Vanderplank PA, Kerr NC, Sukumaran M, Pachnis V, Wynick D. Transgenic overexpression of galanin in the dorsal root ganglia modulates pain-related behavior. Proceedings of the National Academy of Sciences of the United States of America. 100: 6180-5. PMID 12721371 DOI: 10.1073/Pnas.0937087100  0.805
2003 Mahoney SA, Hosking R, Farrant S, Holmes FE, Jacoby AS, Shine J, Iismaa TP, Scott MK, Schmidt R, Wynick D. The second galanin receptor GalR2 plays a key role in neurite outgrowth from adult sensory neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 416-21. PMID 12533601 DOI: 10.1523/Jneurosci.23-02-00416.2003  0.73
2002 Bacon A, Holmes FE, Small CJ, Ghatei M, Mahoney S, Bloom S, Wynick D. Transgenic over-expression of galanin in injured primary sensory neurons. Neuroreport. 13: 2129-32. PMID 12438940 DOI: 10.1097/00001756-200211150-00028  0.756
2002 Wynick D, Bacon A. Targeted disruption of galanin: new insights from knock-out studies. Neuropeptides. 36: 132-44. PMID 12359504 DOI: 10.1054/Npep.2002.0888  0.475
2001 Wynick D, Thompson SW, McMahon SB. The role of galanin as a multi-functional neuropeptide in the nervous system. Current Opinion in Pharmacology. 1: 73-7. PMID 11712539 DOI: 10.1016/S1471-4892(01)00006-6  0.613
2001 Kerr BJ, Thompson SW, Wynick D, McMahon SB. Endogenous galanin is required for the full expression of central sensitization following peripheral nerve injury. Neuroreport. 12: 3331-4. PMID 11711881 DOI: 10.1097/00001756-200110290-00037  0.607
2001 Kerr BJ, Gupta Y, Pope R, Thompson SW, Wynick D, McMahon SB. Endogenous galanin potentiates spinal nociceptive processing following inflammation. Pain. 93: 267-77. PMID 11514086 DOI: 10.1016/S0304-3959(01)00326-8  0.563
2001 Kehr J, Yoshitake T, Wang FH, Wynick D, Holmberg K, Lendahl U, Bartfai T, Yamaguchi M, Hökfelt T, Ogren SO. Microdialysis in freely moving mice: determination of acetylcholine, serotonin and noradrenaline release in galanin transgenic mice. Journal of Neuroscience Methods. 109: 71-80. PMID 11489302 DOI: 10.1016/S0165-0270(01)00403-4  0.368
2001 Pérez SE, Wynick D, Steiner RA, Mufson EJ. Distribution of galaninergic immunoreactivity in the brain of the mouse. The Journal of Comparative Neurology. 434: 158-85. PMID 11331523 DOI: 10.1002/Cne.1171  0.399
2000 Kerr NC, Holmes FE, Wynick D. Galanin-like peptide (GALP) is expressed in rat hypothalamus and pituitary, but not in DRG. Neuroreport. 11: 3909-13. PMID 11117513 DOI: 10.1097/00001756-200011270-00060  0.672
2000 Kerr BJ, Wynick D, Thompson SW, McMahon SB. The biological role of galanin in normal and neuropathic states. Progress in Brain Research. 129: 219-30. PMID 11098692 DOI: 10.1016/S0079-6123(00)29016-X  0.61
2000 O'Meara G, Coumis U, Ma SY, Kehr J, Mahoney S, Bacon A, Allen SJ, Holmes F, Kahl U, Wang FH, Kearns IR, Ove-Ogren S, Dawbarn D, Mufson EJ, Davies C, ... ... Wynick D, et al. Galanin regulates the postnatal survival of a subset of basal forebrain cholinergic neurons. Proceedings of the National Academy of Sciences of the United States of America. 97: 11569-74. PMID 11016971 DOI: 10.1073/Pnas.210254597  0.784
2000 Holmes FE, Mahoney S, King VR, Bacon A, Kerr NC, Pachnis V, Curtis R, Priestley JV, Wynick D. Targeted disruption of the galanin gene reduces the number of sensory neurons and their regenerative capacity. Proceedings of the National Academy of Sciences of the United States of America. 97: 11563-8. PMID 11016970 DOI: 10.1073/Pnas.210221897  0.814
2000 Mazarati AM, Hohmann JG, Bacon A, Liu H, Sankar R, Steiner RA, Wynick D, Wasterlain CG. Modulation of hippocampal excitability and seizures by galanin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 6276-81. PMID 10934278 DOI: 10.1523/Jneurosci.20-16-06276.2000  0.337
2000 Kerr BJ, Cafferty WB, Gupta YK, Bacon A, Wynick D, McMahon SB, Thompson SW. Galanin knockout mice reveal nociceptive deficits following peripheral nerve injury. The European Journal of Neuroscience. 12: 793-802. PMID 10762308 DOI: 10.1046/J.1460-9568.2000.00967.X  0.645
1998 Wynick D, Small CJ, Bloom SR, Pachnis V. Targeted disruption of the murine galanin gene. Annals of the New York Academy of Sciences. 863: 22-47. PMID 9928157 DOI: 10.1111/J.1749-6632.1998.Tb10681.X  0.703
1998 Wynick D, Small CJ, Bacon A, Holmes FE, Norman M, Ormandy CJ, Kilic E, Kerr NC, Ghatei M, Talamantes F, Bloom SR, Pachnis V. Galanin regulates prolactin release and lactotroph proliferation. Proceedings of the National Academy of Sciences of the United States of America. 95: 12671-6. PMID 9770544 DOI: 10.1073/Pnas.95.21.12671  0.741
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