Michael T. Heneka - Related publications

Affiliations: 
University of Bonn, Bonn, Nordrhein-Westfalen, Germany 
Area:
Neurodegeneration
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 Pérez-González M, Mendioroz M, Badesso S, Sucunza D, Roldan M, Espelosín M, Ursua S, Luján R, Cuadrado-Tejedor M, Garcia-Osta A. PLA2G4E, a candidate gene for resilience in Alzheimer´s disease and a new target for dementia treatment. Progress in Neurobiology. 101818. PMID 32380223 DOI: 10.1016/j.pneurobio.2020.101818   
2020 Uddin MS, Kabir MT, Mamun AA, Barreto GE, Rashid M, Perveen A, Ashraf GM. Pharmacological approaches to mitigate neuroinflammation in Alzheimer's disease. International Immunopharmacology. 84: 106479. PMID 32353686 DOI: 10.1016/j.intimp.2020.106479   
2020 Yang WD, Dong WG. [Mechanisms of electroacupuncture for improving Alzheimer's disease from reducing β amyloid protein level]. Zhen Ci Yan Jiu = Acupuncture Research. 45: 426-31. PMID 32447861 DOI: 10.13702/j.1000-0607.180885   
2020 Peng YS, Tang CW, Peng YY, Chang H, Chen CL, Guo SL, Wu LC, Huang MC, Lee HC. Comparative functional genomic analysis of Alzheimer's affected and naturally aging brains. Peerj. 8: e8682. PMID 32219020 DOI: 10.7717/peerj.8682   
2020 Angelopoulou E, Paudel YN, Shaikh MF, Piperi C. Flotillin: A Promising Biomarker for Alzheimer's Disease. Journal of Personalized Medicine. 10. PMID 32225073 DOI: 10.3390/jpm10020020   
2020 Yuan C, Aierken A, Xie Z, Li N, Zhao J, Qing H. The age-related microglial transformation in Alzheimer's disease pathogenesis. Neurobiology of Aging. 92: 82-91. PMID 32408056 DOI: 10.1016/j.neurobiolaging.2020.03.024   
2020 Ghosh S, Durgvanshi S, Agarwal S, Raghunath M, Sinha JK. Current status of drug targets and emerging therapeutic strategies in the management of Alzheimer's disease. Current Neuropharmacology. PMID 32348223 DOI: 10.2174/1570159X18666200429011823   
2020 Gupta SP, Patil VM. Recent Studies on Design and Development of Drugs Against Alzheimer's Disease (AD) Based on Inhibition of BACE-1 and Other AD-causative Agents. Current Topics in Medicinal Chemistry. PMID 32297584 DOI: 10.2174/1568026620666200416091623   
2020 Yang J, Wise L, Fukuchi KI. TLR4 Cross-Talk With NLRP3 Inflammasome and Complement Signaling Pathways in Alzheimer's Disease. Frontiers in Immunology. 11: 724. PMID 32391019 DOI: 10.3389/fimmu.2020.00724   
2020 Gee MS, Son SH, Jeon SH, Do J, Kim N, Ju YJ, Lee SJ, Chung EK, Inn KS, Kim NJ, Lee JK. A selective p38α/β MAPK inhibitor alleviates neuropathology and cognitive impairment, and modulates microglia function in 5XFAD mouse. Alzheimer's Research & Therapy. 12: 45. PMID 32317025 DOI: 10.1186/s13195-020-00617-2   
2020 Husna Ibrahim N, Yahaya MF, Mohamed W, Teoh SL, Hui CK, Kumar J. Pharmacotherapy of Alzheimer's Disease: Seeking Clarity in a Time of Uncertainty. Frontiers in Pharmacology. 11: 261. PMID 32265696 DOI: 10.3389/fphar.2020.00261   
2020 Xu XD, Teng Y, Zou JY, Ye Y, Song H, Wang ZY. Effects of lycopene on vascular remodeling through the LXR-PI3K-AKT signaling pathway in APP/PS1 mice. Biochemical and Biophysical Research Communications. PMID 32253029 DOI: 10.1016/j.bbrc.2020.02.063   
2020 Cho HJ, Sharma AK, Zhang Y, Gross ML, Mirica LM. A Multifunctional Chemical Agent as an Attenuator of Amyloid Burden and Neuroinflammation in Alzheimer's Disease. Acs Chemical Neuroscience. PMID 32310630 DOI: 10.1021/acschemneuro.0c00114   
2020 Novak G, Streffer JR, Timmers M, Henley D, Brashear HR, Bogert J, Russu A, Janssens L, Tesseur I, Tritsmans L, Van Nueten L, Engelborghs S. Long-term safety and tolerability of atabecestat (JNJ-54861911), an oral BACE1 inhibitor, in early Alzheimer's disease spectrum patients: a randomized, double-blind, placebo-controlled study and a two-period extension study. Alzheimer's Research & Therapy. 12: 58. PMID 32410694 DOI: 10.1186/s13195-020-00614-5   
2020 Ren P, Chen J, Li B, Zhang M, Yang B, Guo X, Chen Z, Cheng H, Wang P, Wang S, Wang N, Zhang G, Wu X, Ma D, Guan D, et al. Nrf2 Ablation Promotes Alzheimer's Disease-Like Pathology in APP/PS1 Transgenic Mice: The Role of Neuroinflammation and Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2020: 3050971. PMID 32454936 DOI: 10.1155/2020/3050971   
2020 Mullane K, Williams M. Alzheimer's disease beyond amyloid: can the repetitive failures of amyloid-targeted therapeutics inform future approaches to dementia drug discovery? Biochemical Pharmacology. 113945. PMID 32247851 DOI: 10.1016/j.bcp.2020.113945   
2020 Kong Y, Peng Q, Lv N, Yuan J, Deng Z, Liang X, Chen S, Wang L. Paeoniflorin exerts neuroprotective effects in a transgenic mouse model of Alzheimer's disease via activation of adenosine A receptor. Neuroscience Letters. 135016. PMID 32371159 DOI: 10.1016/j.neulet.2020.135016   
2020 Vyas Y, Montgomery JM, Cheyne JE. Hippocampal Deficits in Amyloid-β-Related Rodent Models of Alzheimer's Disease. Frontiers in Neuroscience. 14: 266. PMID 32317913 DOI: 10.3389/fnins.2020.00266   
2020 Deng X, Zhao S, Liu X, Han L, Wang R, Hao H, Jiao Y, Han S, Bai C. : a source for anti-Alzheimer's disease drugs. Pharmaceutical Biology. 58: 410-416. PMID 32429787 DOI: 10.1080/13880209.2020.1758732   
2020 Ní Chasaide C, Lynch MA. The role of the immune system in driving neuroinflammation. Brain and Neuroscience Advances. 4: 2398212819901082. PMID 32219178 DOI: 10.1177/2398212819901082   
2020 Malpas CB, Sharmin S, Kalincik T. The histopathological staging of tau, but not amyloid, corresponds to antemortem cognitive status, dementia stage, functional abilities, and neuropsychiatric symptoms. The International Journal of Neuroscience. 1-13. PMID 32303140 DOI: 10.1080/00207454.2020.1758087   
2020 Johnson ECB, Dammer EB, Duong DM, Ping L, Zhou M, Yin L, Higginbotham LA, Guajardo A, White B, Troncoso JC, Thambisetty M, Montine TJ, Lee EB, Trojanowski JQ, Beach TG, et al. Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation. Nature Medicine. PMID 32284590 DOI: 10.1038/s41591-020-0815-6   
2020 Eke CS, Jammeh E, Li X, Carroll C, Pearson S, Ifeachor E. Early Detection of Alzheimer's Disease with Blood Plasma Proteins using Support Vector Machines. Ieee Journal of Biomedical and Health Informatics. PMID 32340968 DOI: 10.1109/JBHI.2020.2984355   
2020 Lim KH, Joo JY. Predictive Potential of Circulating Ube2h mRNA as an E2 Ubiquitin-Conjugating Enzyme for Diagnosis or Treatment of Alzheimer's Disease. International Journal of Molecular Sciences. 21. PMID 32403399 DOI: 10.3390/ijms21093398   
2020 Kou X, Chen D, Chen N. The Regulation of microRNAs in Alzheimer's Disease. Frontiers in Neurology. 11: 288. PMID 32362867 DOI: 10.3389/fneur.2020.00288   
2020 Kim KY, Suh YH, Chang KA. Therapeutic Effects of Human Amniotic Epithelial Stem Cells in a Transgenic Mouse Model of Alzheimer's Disease. International Journal of Molecular Sciences. 21. PMID 32290355 DOI: 10.3390/ijms21072658   
2020 Amponsah AE, Feng B, Guo R, Zhang W, He J, Kong D, Dong T, Ma J, Cui H. Fragmentation of brain apolipoprotein E (ApoE) and its relevance in Alzheimer's disease. Reviews in the Neurosciences. PMID 32364519 DOI: 10.1515/revneuro-2019-0115   
2020 Harris LD, Jasem S, Licchesi JDF. The Ubiquitin System in Alzheimer's Disease. Advances in Experimental Medicine and Biology. 1233: 195-221. PMID 32274758 DOI: 10.1007/978-3-030-38266-7_8   
2020 Qin T, Prins S, Groeneveld GJ, Van Westen G, de Vries HE, Wong YC, Bischoff LJM, de Lange ECM. Utility of Animal Models to Understand Human Alzheimer's Disease, Using the Mastermind Research Approach to Avoid Unnecessary Further Sacrifices of Animals. International Journal of Molecular Sciences. 21. PMID 32365768 DOI: 10.3390/ijms21093158   
2020 Zetterberg H, Bendlin BB. Biomarkers for Alzheimer's disease-preparing for a new era of disease-modifying therapies. Molecular Psychiatry. PMID 32251378 DOI: 10.1038/s41380-020-0721-9   
2020 Bagyinszky E, Giau VV, An SA. Transcriptomics in Alzheimer's Disease: Aspects and Challenges. International Journal of Molecular Sciences. 21. PMID 32429229 DOI: 10.3390/ijms21103517   
2020 Leblhuber F, Steiner K, Geisler S, Fuchs D, Gostner JM. On the possible relevance of bottom-up pathways in the pathogenesis of Alzheimer's dementia. Current Topics in Medicinal Chemistry. PMID 32407280 DOI: 10.2174/1568026620666200514090359   
2020 Chen Y, Bian Y, Wang JW, Gong TT, Ying YM, Ma LF, Shan WG, Xie XQ, Zhan ZJ. Effects of α-Mangostin Derivatives on the Alzheimer's Disease Model of Rats and Their Mechanism: A Combination of Experimental Study and Computational Systems Pharmacology Analysis. Acs Omega. 5: 9846-9863. PMID 32391472 DOI: 10.1021/acsomega.0c00057   
2020 Zameer S, Alam M, Hussain S, Vohora D, Ali J, Akhtar M. Neuroprotective role of alendronate against APP processing and neuroinflammation in mice fed a high fat diet. Brain Research Bulletin. PMID 32389800 DOI: 10.1016/j.brainresbull.2020.04.010   
2020 Oikari LE, Pandit R, Stewart R, Cuní-López C, Quek H, Sutharsan R, Rantanen LM, Oksanen M, Lehtonen S, de Boer CM, Polo JM, Götz J, Koistinaho J, White AR. Altered Brain Endothelial Cell Phenotype from a Familial Alzheimer Mutation and Its Potential Implications for Amyloid Clearance and Drug Delivery. Stem Cell Reports. PMID 32275861 DOI: 10.1016/j.stemcr.2020.03.011   
2020 Xie Y, Yan L, Zeng H, Chen W, Lu JH, Wan JB, Su H, Yao X. Fish oil protects the blood-brain barrier integrity in a mouse model of Alzheimer's disease. Chinese Medicine. 15: 29. PMID 32256685 DOI: 10.1186/s13020-020-00314-0   
2020 Abbink MR, Kotah JM, Hoeijmakers L, Mak A, Yvon-Durocher G, van der Gaag B, Lucassen PJ, Korosi A. Characterization of astrocytes throughout life in wildtype and APP/PS1 mice after early-life stress exposure. Journal of Neuroinflammation. 17: 91. PMID 32197653 DOI: 10.1186/s12974-020-01762-z   
2020 Chen SY, Gao Y, Sun JY, Meng XL, Yang D, Fan LH, Xiang L, Wang P. Traditional Chinese Medicine: Role in Reducing β-Amyloid, Apoptosis, Autophagy, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction of Alzheimer's Disease. Frontiers in Pharmacology. 11: 497. PMID 32390843 DOI: 10.3389/fphar.2020.00497   
2020 Song YY, Xu WT, Zhang XC, Ni GX. Mechanisms of Electroacupuncture on Alzheimer's Disease: A Review of Animal Studies. Chinese Journal of Integrative Medicine. PMID 32318906 DOI: 10.1007/s11655-020-3092-9   
2020 Walsh DM, Selkoe DJ. Amyloid β-protein and beyond: the path forward in Alzheimer's disease. Current Opinion in Neurobiology. 61: 116-124. PMID 32197217 DOI: 10.1016/j.conb.2020.02.003   
2020 Li N, Wang G, Lu H. Development of Alzheimer's Disease after Myocardial Infarction. Journal of Alzheimer's Disease : Jad. PMID 32280100 DOI: 10.3233/JAD-200068   
2020 Cheng Y, Tian DY, Wang YJ. Peripheral clearance of brain-derived Aβ in Alzheimer's disease: pathophysiology and therapeutic perspectives. Translational Neurodegeneration. 9: 16. PMID 32381118 DOI: 10.1186/s40035-020-00195-1   
2020 Jiang R, Wu XF, Wang B, Guan RX, Lv LM, Li AP, Lei L, Ma Y, Li N, Li QF, Ma QH, Zhao J, Li S. Reduction of NgR in perforant path decreases amyloid-β peptide production and ameliorates synaptic and cognitive deficits in APP/PS1 mice. Alzheimer's Research & Therapy. 12: 47. PMID 32331528 DOI: 10.1186/s13195-020-00616-3   
2020 Bernath MM, Bhattacharyya S, Nho K, Barupal DK, Fiehn O, Baillie R, Risacher SL, Arnold M, Jacobson T, Trojanowski JQ, Shaw LM, Weiner MW, Doraiswamy PM, Kaddurah-Daouk R, Saykin AJ, , et al. Serum triglycerides in Alzheimer disease: Relation to neuroimaging and CSF biomarkers. Neurology. PMID 32358220 DOI: 10.1212/WNL.0000000000009436   
2020 Dagan H, Flashner-Abramson E, Vasudevan S, Jubran MR, Cohen E, Kravchenko-Balasha N. Exploring Alzheimer's Disease Molecular Variability via Calculation of Personalized Transcriptional Signatures. Biomolecules. 10. PMID 32225014 DOI: 10.3390/biom10040503   
2020 Yang Y, Zhou J, Li J. Regulation of exosome for Alzheimer's disease derived from mesenchymal stem cells. Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences. 45: 169-175. PMID 32386043 DOI: 10.11817/j.issn.1672-7347.2020.180779   
2020 Lim CH, Kaur P, Teo E, Lam VYM, Zhu F, Kibat C, Gruber J, Mathuru AS, Tolwinski NS. Application of optogenetic Amyloid-β distinguishes between metabolic and physical damage in neurodegeneration. Elife. 9. PMID 32228858 DOI: 10.7554/eLife.52589   
2020 Picone P, Di Carlo M, Nuzzo D. Obesity and Alzheimer disease: molecular bases. The European Journal of Neuroscience. PMID 32323378 DOI: 10.1111/ejn.14758   
2020 Cole MA, Seabrook GR. On the horizon-the value and promise of the global pipeline of Alzheimer's disease therapeutics. Alzheimer's & Dementia (New York, N. Y.). 6: e12009. PMID 32405530 DOI: 10.1002/trc2.12009   
2020 Pan J, Ma N, Yu B, Zhang W, Wan J. Transcriptomic profiling of microglia and astrocytes throughout aging. Journal of Neuroinflammation. 17: 97. PMID 32238175 DOI: 10.1186/s12974-020-01774-9