Timothy W. Secomb - Publications

Affiliations: 
Applied Mathematics University of Arizona, Tucson, AZ 
Area:
Mathematics, Biomedical Engineering

169 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Alberding JP, Secomb TW. Simulation of Angiogenesis in Three Dimensions: Development of the Retinal Circulation. Bulletin of Mathematical Biology. 85: 27. PMID 36842140 DOI: 10.1007/s11538-023-01126-7  0.3
2022 Roy TK, Secomb TW. Functional implications of microvascular heterogeneity for oxygen uptake and utilization. Physiological Reports. 10: e15303. PMID 35581743 DOI: 10.14814/phy2.15303  0.355
2021 Fry BC, Secomb TW. Distinct roles of red-blood-cell-derived and wall-derived mechanisms in metabolic regulation of blood flow. Microcirculation (New York, N.Y. : 1994). PMID 33650127 DOI: 10.1111/micc.12690  0.789
2020 Roy TK, Secomb TW. Effects of impaired microvascular flow regulation on metabolism-perfusion matching and organ function. Microcirculation (New York, N.Y. : 1994). e12673. PMID 33236393 DOI: 10.1111/micc.12673  0.368
2020 Şencan İ, Esipova T, Kılıç K, Li B, Desjardins M, Yaseen MA, Wang H, Porter JE, Kura S, Fu B, Secomb TW, Boas DA, Vinogradov SA, Devor A, Sakadžić S. Optical measurement of microvascular oxygenation and blood flow responses in awake mouse cortex during functional activation. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X20928011. PMID 32515672 DOI: 10.1177/0271678X20928011  0.346
2020 Celaya-Alcala JT, Lee GV, Smith AF, Li B, Sakadžić S, Boas DA, Secomb TW. Simulation of oxygen transport and estimation of tissue perfusion in extensive microvascular networks: Application to cerebral cortex. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X20927100. PMID 32501155 DOI: 10.1177/0271678X20927100  0.46
2020 Secomb TW, Celaya-Alcala JT, Boas DA, Sakadžić S. The Problem of Estimating Tissue Perfusion from Observations of Microvascular Flow The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.05843  0.343
2020 Roy TK, Secomb TW. Characterizing the Effect of the Hypoxic Vasoconstriction Response Curve on Blood Flow Distribution and Oxygenation in the Lung The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.04215  0.418
2019 Burton JK, Bottino D, Secomb TW. A Systems Pharmacology Model for Drug Delivery to Solid Tumors by Antibody-Drug Conjugates: Implications for Bystander Effects. The Aaps Journal. 22: 12. PMID 31828446 DOI: 10.1208/S12248-019-0390-2  0.323
2019 Secomb TW, Bullock KV, Boas DA, Sakadžić S. The mass transfer coefficient for oxygen transport from blood to tissue in cerebral cortex. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X19870068. PMID 31423930 DOI: 10.1177/0271678X19870068  0.436
2019 Shepherd JRA, Dominelli PB, Roy TK, Secomb TW, Hoyer JD, Oliveira JL, Joyner MJ. Modelling the relationships between haemoglobin oxygen affinity and the oxygen cascade in humans. The Journal of Physiology. PMID 31290158 DOI: 10.1113/Jp277591  0.331
2019 Shipley RJ, Smith AF, Sweeney PW, Pries AR, Secomb TW. A hybrid discrete-continuum approach for modelling microcirculatory blood flow. Mathematical Medicine and Biology : a Journal of the Ima. PMID 30892609 DOI: 10.1093/Imammb/Dqz006  0.461
2019 Secomb T. Decision letter: Imaging single-cell blood flow in the smallest to largest vessels in the living retina Elife. DOI: 10.7554/Elife.45077.027  0.392
2018 Roy TK, Secomb TW. Effects of Pulmonary Flow Heterogeneity on Oxygen Transport Parameters in Exercise. Respiratory Physiology & Neurobiology. PMID 30321626 DOI: 10.1016/J.Resp.2018.10.004  0.39
2018 Lücker A, Secomb TW, Barrett MJP, Weber B, Jenny P. The Relation Between Capillary Transit Times and Hemoglobin Saturation Heterogeneity. Part 2: Capillary Networks. Frontiers in Physiology. 9: 1296. PMID 30298017 DOI: 10.3389/Fphys.2018.01296  0.436
2018 Lücker A, Secomb TW, Weber B, Jenny P. The Relation Between Capillary Transit Times and Hemoglobin Saturation Heterogeneity. Part 1: Theoretical Models. Frontiers in Physiology. 9: 420. PMID 29755365 DOI: 10.3389/Fphys.2018.00420  0.431
2018 Rasmussen PM, Secomb TW, Pries AR. Modeling the hematocrit distribution in microcirculatory networks: A quantitative evaluation of a phase separation model. Microcirculation (New York, N.Y. : 1994). PMID 29457313 DOI: 10.1111/Micc.12445  0.303
2017 Reglin B, Secomb TW, Pries AR. Structural Control of Microvessel Diameters: Origins of Metabolic Signals. Frontiers in Physiology. 8: 813. PMID 29114229 DOI: 10.3389/Fphys.2017.00813  0.457
2017 Xiang W, Reglin B, Nitzsche B, Maibier M, Rong W, Hoffmann B, Ruggeri A, Guimarães P, Secomb TW, Pries AR. Dynamic remodeling of arteriolar collaterals after acute occlusion in chick chorioallantoic membrane. Microcirculation (New York, N.Y. : 1994). PMID 28075525 DOI: 10.1111/Micc.12351  0.343
2017 Secomb TW. Blood Flow in the Microcirculation Annual Review of Fluid Mechanics. 49: 443-461. DOI: 10.1146/Annurev-Fluid-010816-060302  0.492
2016 Rasmussen PM, Smith AF, Sakadžić S, Boas DA, Pries AR, Secomb TW, Østergaard L. Model based inference from microvascular measurements: Combining experimental measurements and model predictions using a Bayesian probabilistic approach. Microcirculation (New York, N.Y. : 1994). PMID 27987383 DOI: 10.1111/Micc.12343  0.308
2016 Lücker A, Secomb TW, Weber B, Jenny P. The relative influence of hematocrit and red blood cell velocity on oxygen transport from capillaries to tissue. Microcirculation (New York, N.Y. : 1994). PMID 27893186 DOI: 10.1111/Micc.12337  0.454
2016 Gagnon L, Smith AF, Boas DA, Devor A, Secomb TW, Sakadžić S. Modeling of Cerebral Oxygen Transport Based on In vivo Microscopic Imaging of Microvascular Network Structure, Blood Flow, and Oxygenation. Frontiers in Computational Neuroscience. 10: 82. PMID 27630556 DOI: 10.3389/Fncom.2016.00082  0.464
2016 Maibier M, Reglin B, Nitzsche B, Xiang W, Rong WW, Hoffmann B, Djonov V, Secomb TW, Pries AR. Structure and hemodynamics of vascular networks in the chorioallantoic membrane of the chicken. American Journal of Physiology. Heart and Circulatory Physiology. ajpheart.00786.2015. PMID 27402670 DOI: 10.1152/Ajpheart.00786.2015  0.31
2015 Secomb TW, Pries AR. Microvascular plasticity: angiogenesis in health and disease. Preface. Microcirculation (New York, N.Y. : 1994). PMID 26639099 DOI: 10.1111/Micc.12262  0.326
2015 Hariprasad DS, Secomb TW. Prediction of noninertial focusing of red blood cells in Poiseuille flow. Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. 92: 033008. PMID 26465557 DOI: 10.1103/Physreve.92.033008  0.773
2015 Secomb TW. A Green's function method for simulation of time-dependent solute transport and reaction in realistic microvascular geometries. Mathematical Medicine and Biology : a Journal of the Ima. PMID 26443811 DOI: 10.1093/Imammb/Dqv031  0.363
2015 Secomb TW. Krogh-cylinder and infinite-domain models for washout of an inert diffusible solute from tissue. Microcirculation (New York, N.Y. : 1994). 22: 91-8. PMID 25377492 DOI: 10.1111/Micc.12180  0.381
2014 Hariprasad DS, Secomb TW. Two-dimensional simulation of red blood cell motion near a wall under a lateral force. Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. 90: 053014. PMID 25493888 DOI: 10.1103/Physreve.90.053014  0.754
2014 Pries AR, Secomb TW. Making microvascular networks work: angiogenesis, remodeling, and pruning. Physiology (Bethesda, Md.). 29: 446-55. PMID 25362638 DOI: 10.1152/Physiol.00012.2014  0.42
2014 Roy TK, Secomb TW. Functional sympatholysis and sympathetic escape in a theoretical model for blood flow regulation. Frontiers in Physiology. 5: 192. PMID 24904428 DOI: 10.3389/Fphys.2014.00192  0.441
2014 Roy TK, Secomb TW. Theoretical analysis of the determinants of lung oxygen diffusing capacity. Journal of Theoretical Biology. 351: 1-8. PMID 24560722 DOI: 10.1016/J.Jtbi.2014.02.009  0.363
2013 Secomb TW, Pries AR. Blood viscosity in microvessels: experiment and theory. Comptes Rendus. Physique. 14: 470-478. PMID 25089124 DOI: 10.1016/J.Crhy.2013.04.002  0.437
2013 Foehrenbacher A, Secomb TW, Wilson WR, Hicks KO. Design of optimized hypoxia-activated prodrugs using pharmacokinetic/pharmacodynamic modeling. Frontiers in Oncology. 3: 314. PMID 24409417 DOI: 10.3389/Fonc.2013.00314  0.331
2013 Foehrenbacher A, Patel K, Abbattista MR, Guise CP, Secomb TW, Wilson WR, Hicks KO. The Role of Bystander Effects in the Antitumor Activity of the Hypoxia-Activated Prodrug PR-104. Frontiers in Oncology. 3: 263. PMID 24109591 DOI: 10.3389/Fonc.2013.00263  0.305
2013 Fry BC, Roy TK, Secomb TW. Capillary recruitment in a theoretical model for blood flow regulation in heterogeneous microvessel networks. Physiological Reports. 1: e00050. PMID 24040516 DOI: 10.1002/Phy2.50  0.817
2013 Fontanella AN, Schroeder T, Hochman DW, Chen RE, Hanna G, Haglund MM, Rajaram N, Frees AE, Secomb TW, Palmer GM, Dewhirst MW. Quantitative mapping of hemodynamics in the lung, brain, and dorsal window chamber-grown tumors using a novel, automated algorithm. Microcirculation (New York, N.Y. : 1994). 20: 724-35. PMID 23781901 DOI: 10.1111/Micc.12072  0.317
2013 Secomb TW, Alberding JP, Hsu R, Dewhirst MW, Pries AR. Angiogenesis: an adaptive dynamic biological patterning problem. Plos Computational Biology. 9: e1002983. PMID 23555218 DOI: 10.1371/Journal.Pcbi.1002983  0.368
2013 Ackermann M, Tsuda A, Secomb TW, Mentzer SJ, Konerding MA. Intussusceptive remodeling of vascular branch angles in chemically-induced murine colitis. Microvascular Research. 87: 75-82. PMID 23485588 DOI: 10.1016/J.Mvr.2013.02.002  0.334
2012 Hariprasad DS, Secomb TW. Motion of red blood cells near microvessel walls: effects of a porous wall layer. Journal of Fluid Mechanics. 705: 195-212. PMID 23493820 DOI: 10.1017/Jfm.2012.102  0.777
2012 Gruionu G, Hoying JB, Pries AR, Secomb TW. Structural remodeling of the mouse gracilis artery: coordinated changes in diameter and medial area maintain circumferential stress. Microcirculation (New York, N.Y. : 1994). 19: 610-8. PMID 22587333 DOI: 10.1111/J.1549-8719.2012.00194.X  0.721
2012 Fry BC, Lee J, Smith NP, Secomb TW. Estimation of blood flow rates in large microvascular networks. Microcirculation (New York, N.Y. : 1994). 19: 530-8. PMID 22506980 DOI: 10.1111/J.1549-8719.2012.00184.X  0.781
2012 Roy TK, Pries AR, Secomb TW. Theoretical comparison of wall-derived and erythrocyte-derived mechanisms for metabolic flow regulation in heterogeneous microvascular networks. American Journal of Physiology. Heart and Circulatory Physiology. 302: H1945-52. PMID 22408023 DOI: 10.1152/Ajpheart.01176.2011  0.458
2012 Secomb TW, Dewhirst MW, Pries AR. Structural adaptation of normal and tumour vascular networks. Basic & Clinical Pharmacology & Toxicology. 110: 63-9. PMID 21995550 DOI: 10.1111/J.1742-7843.2011.00815.X  0.409
2012 Arciero JC, Secomb TW. Spontaneous oscillations in a model for active control of microvessel diameters. Mathematical Medicine and Biology : a Journal of the Ima. 29: 163-80. PMID 21525236 DOI: 10.1093/Imammb/Dqr005  0.75
2011 Barber JO, Restrepo JM, Secomb TW. Simulated Red Blood Cell Motion in Microvessel Bifurcations: Effects of Cell-Cell Interactions on Cell Partitioning. Cardiovascular Engineering and Technology. 2: 349-360. PMID 23555330 DOI: 10.1007/S13239-011-0064-4  0.624
2011 Pries AR, Reglin B, Secomb TW. Modeling of angioadaptation: insights for vascular development. The International Journal of Developmental Biology. 55: 399-405. PMID 21858766 DOI: 10.1387/Ijdb.103218Ap  0.427
2011 Waters SL, Alastruey J, Beard DA, Bovendeerd PH, Davies PF, Jayaraman G, Jensen OE, Lee J, Parker KH, Popel AS, Secomb TW, Siebes M, Sherwin SJ, Shipley RJ, Smith NP, et al. Theoretical models for coronary vascular biomechanics: progress & challenges. Progress in Biophysics and Molecular Biology. 104: 49-76. PMID 21040741 DOI: 10.1016/J.Pbiomolbio.2010.10.001  0.365
2011 Secomb TW. Mechanics and computational simulation of blood flow in microvessels. Medical Engineering & Physics. 33: 800-4. PMID 21036096 DOI: 10.1016/J.Medengphy.2010.09.016  0.406
2010 Pries AR, Höpfner M, le Noble F, Dewhirst MW, Secomb TW. The shunt problem: control of functional shunting in normal and tumour vasculature. Nature Reviews. Cancer. 10: 587-93. PMID 20631803 DOI: 10.1038/Nrc2895  0.431
2010 Konerding MA, Turhan A, Ravnic DJ, Lin M, Fuchs C, Secomb TW, Tsuda A, Mentzer SJ. Inflammation-induced intussusceptive angiogenesis in murine colitis. Anatomical Record (Hoboken, N.J. : 2007). 293: 849-57. PMID 20225210 DOI: 10.1002/Ar.21110  0.338
2009 Reglin B, Secomb TW, Pries AR. Structural adaptation of microvessel diameters in response to metabolic stimuli: where are the oxygen sensors? American Journal of Physiology. Heart and Circulatory Physiology. 297: H2206-19. PMID 19783778 DOI: 10.1152/Ajpheart.00348.2009  0.443
2009 Pries AR, Cornelissen AJ, Sloot AA, Hinkeldey M, Dreher MR, Höpfner M, Dewhirst MW, Secomb TW. Structural adaptation and heterogeneity of normal and tumor microvascular networks. Plos Computational Biology. 5: e1000394. PMID 19478883 DOI: 10.1371/Journal.Pcbi.1000394  0.371
2009 Pries AR, Secomb TW. Origins of heterogeneity in tissue perfusion and metabolism. Cardiovascular Research. 81: 328-35. PMID 19028725 DOI: 10.1093/Cvr/Cvn318  0.466
2008 Secomb TW. Theoretical models for regulation of blood flow. Microcirculation (New York, N.Y. : 1994). 15: 765-75. PMID 18951240 DOI: 10.1080/10739680802350112  0.459
2008 Pries AR, Secomb TW. Modeling structural adaptation of microcirculation. Microcirculation (New York, N.Y. : 1994). 15: 753-64. PMID 18802843 DOI: 10.1080/10739680802229076  0.353
2008 Carlson BE, Arciero JC, Secomb TW. Theoretical model of blood flow autoregulation: roles of myogenic, shear-dependent, and metabolic responses. American Journal of Physiology. Heart and Circulatory Physiology. 295: H1572-9. PMID 18723769 DOI: 10.1152/Ajpheart.00262.2008  0.768
2008 Arciero JC, Carlson BE, Secomb TW. Theoretical model of metabolic blood flow regulation: roles of ATP release by red blood cells and conducted responses. American Journal of Physiology. Heart and Circulatory Physiology. 295: H1562-71. PMID 18689501 DOI: 10.1152/Ajpheart.00261.2008  0.763
2008 Barber JO, Alberding JP, Restrepo JM, Secomb TW. Simulated two-dimensional red blood cell motion, deformation, and partitioning in microvessel bifurcations. Annals of Biomedical Engineering. 36: 1690-8. PMID 18686035 DOI: 10.1007/S10439-008-9546-4  0.669
2008 Pries AR, Secomb TW. Blood Flow in Microvascular Networks Microcirculation. 3-36. DOI: 10.1016/B978-0-12-374530-9.00001-2  0.437
2007 Styp-Rekowska B, Disassa NM, Reglin B, Ulm L, Kuppe H, Secomb TW, Pries AR. An imaging spectroscopy approach for measurement of oxygen saturation and hematocrit during intravital microscopy Microcirculation. 14: 207-221. PMID 17454673 DOI: 10.1080/10739680601139302  0.345
2007 Secomb TW, Styp-Rekowska B, Pries AR. Two-dimensional simulation of red blood cell deformation and lateral migration in microvessels. Annals of Biomedical Engineering. 35: 755-65. PMID 17380392 DOI: 10.1007/S10439-007-9275-0  0.382
2007 Cárdenas-Navia LI, Secomb TW, Dewhirst MW. Effects of fluctuating oxygenation on tirapazamine efficacy: Theoretical predictions. International Journal of Radiation Oncology, Biology, Physics. 67: 581-6. PMID 17236974 DOI: 10.1016/J.Ijrobp.2006.10.002  0.333
2007 Goriely AR, Baldwin AL, Secomb TW. Transient diffusion of albumin in aortic walls: effects of binding to medial elastin layers. American Journal of Physiology. Heart and Circulatory Physiology. 292: H2195-201. PMID 17208986 DOI: 10.1152/Ajpheart.01294.2006  0.318
2007 Skotheim JM, Secomb TW. Red blood cells and other nonspherical capsules in shear flow: Oscillatory dynamics and the tank-treading-to-tumbling transition Physical Review Letters. 98. DOI: 10.1103/Physrevlett.98.078301  0.407
2007 Arciero JC, Carlson BE, Secomb TW. Roles of oxygen‐dependent ATP release by red blood cells and conducted responses in metabolic regulation of blood flow The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A479-C  0.742
2006 Lanzen J, Braun RD, Klitzman B, Brizel D, Secomb TW, Dewhirst MW. Direct demonstration of instabilities in oxygen concentrations within the extravascular compartment of an experimental tumor. Cancer Research. 66: 2219-23. PMID 16489024 DOI: 10.1158/0008-5472.Can-03-2958  0.389
2006 Secomb TW, Hsu R, Pries AR. Tribology of capillary blood flow Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology. 220: 767-774. DOI: 10.1243/13506501JET121  0.347
2006 Secomb T, Carlson B. Theoretical models for flow regulation based on the length-tension characteristics of vascular smooth muscle Journal of Biomechanics. 39: S374. DOI: 10.1016/S0021-9290(06)84505-7  0.401
2006 Secomb T, Pries A. Estimation of rheologically effective endothelial surface layer thickness from blood flow distributions observed in microvascular networks Journal of Biomechanics. 39: S335. DOI: 10.1016/S0021-9290(06)84324-1  0.386
2006 Secomb T, Pries A. Simulation of red blood cell deformation and radial migration in microvessels Journal of Biomechanics. 39: S331-S332. DOI: 10.1016/S0021-9290(06)84308-3  0.359
2005 Pries AR, Reglin B, Secomb TW. Remodeling of blood vessels: responses of diameter and wall thickness to hemodynamic and metabolic stimuli. Hypertension. 46: 725-31. PMID 16172421 DOI: 10.1161/01.Hyp.0000184428.16429.Be  0.423
2005 Pries AR, Secomb TW. Microvascular blood viscosity in vivo and the endothelial surface layer American Journal of Physiology - Heart and Circulatory Physiology. 289: H2657-H2664. PMID 16040719 DOI: 10.1152/Ajpheart.00297.2005  0.48
2005 El-Kareh AW, Secomb TW. Two-mechanism peak concentration model for cellular pharmacodynamics of Doxorubicin. Neoplasia (New York, N.Y.). 7: 705-13. PMID 16026650 DOI: 10.1593/Neo.05118  0.306
2005 Carlson BE, Secomb TW. A theoretical model for the myogenic response based on the length-tension characteristics of vascular smooth muscle. Microcirculation (New York, N.Y. : 1994). 12: 327-38. PMID 16020079 DOI: 10.1080/10739680590934745  0.397
2005 Pries AR, Secomb TW. Control of blood vessel structure: Insights from theoretical models American Journal of Physiology - Heart and Circulatory Physiology. 288: H1010-H1015. PMID 15706037 DOI: 10.1152/Ajpheart.00752.2004  0.387
2005 Gruionu G, Hoying JB, Gruionu LG, Laughlin MH, Secomb TW. Structural adaptation increases predicted perfusion capacity after vessel obstruction in arteriolar arcade network of pig skeletal muscle. American Journal of Physiology. Heart and Circulatory Physiology. 288: H2778-84. PMID 15681697 DOI: 10.1152/Ajpheart.00917.2004  0.726
2005 Gruionu G, Hoying JB, Pries AR, Secomb TW. Structural remodeling of mouse gracilis artery after chronic alteration in blood supply. American Journal of Physiology. Heart and Circulatory Physiology. 288: H2047-54. PMID 15604133 DOI: 10.1152/Ajpheart.00496.2004  0.723
2004 Secomb TW, Hsu R, Park EY, Dewhirst MW. Green's function methods for analysis of oxygen delivery to tissue by microvascular networks. Annals of Biomedical Engineering. 32: 1519-29. PMID 15636112 DOI: 10.1114/B:Abme.0000049036.08817.44  0.362
2004 McGuire BJ, Secomb TW. Theoretical predictions of maximal oxygen consumption in hypoxia: effects of transport limitations. Respiratory Physiology & Neurobiology. 143: 87-97. PMID 15477175 DOI: 10.1016/J.Resp.2004.07.001  0.777
2004 Cárdenas-Navia LI, Yu D, Braun RD, Brizel DM, Secomb TW, Dewhirst MW. Tumor-dependent kinetics of partial pressure of oxygen fluctuations during air and oxygen breathing. Cancer Research. 64: 6010-7. PMID 15342381 DOI: 10.1158/0008-5472.Can-03-0947  0.32
2004 Lo A, Fuglevand AJ, Secomb TW. Theoretical simulation of K(+)-based mechanisms for regulation of capillary perfusion in skeletal muscle. American Journal of Physiology. Heart and Circulatory Physiology. 287: H833-40. PMID 15277205 DOI: 10.1152/Ajpheart.00139.2004  0.63
2004 Secomb TW, Hsu R, Dewhirst MW. Synergistic effects of hyperoxic gas breathing and reduced oxygen consumption on tumor oxygenation: a theoretical model. International Journal of Radiation Oncology, Biology, Physics. 59: 572-8. PMID 15145178 DOI: 10.1016/J.Ijrobp.2004.01.039  0.323
2003 Pries AR, Secomb TW. Rheology of the microcirculation Clinical Hemorheology and Microcirculation. 29: 143-148. PMID 14724335  0.369
2003 McGuire BJ, Secomb TW. Estimation of capillary density in human skeletal muscle based on maximal oxygen consumption rates. American Journal of Physiology. Heart and Circulatory Physiology. 285: H2382-91. PMID 12893642 DOI: 10.1152/Ajpheart.00559.2003  0.784
2003 Secomb TW, Konerding MA, West CA, Su M, Young AJ, Mentzer SJ. Microangiectasias: structural regulators of lymphocyte transmigration. Proceedings of the National Academy of Sciences of the United States of America. 100: 7231-4. PMID 12782790 DOI: 10.1073/Pnas.1232173100  0.362
2003 Lo A, Fuglevand AJ, Secomb TW. Oxygen delivery to skeletal muscle fibers: effects of microvascular unit structure and control mechanisms. American Journal of Physiology. Heart and Circulatory Physiology. 285: H955-63. PMID 12738621 DOI: 10.1152/Ajpheart.00278.2003  0.64
2003 Pries AR, Reglin B, Secomb TW. Structural response of microcirculatory networks to changes in demand: Information transfer by shear stress American Journal of Physiology - Heart and Circulatory Physiology. 284: H2204-H2212. PMID 12573998 DOI: 10.1152/Ajpheart.00757.2002  0.39
2002 Secomb TW, Pries AR. Information transfer in microvascular networks. Microcirculation (New York, N.Y. : 1994). 9: 377-87. PMID 12375175 DOI: 10.1038/Sj.Mn.7800146  0.394
2002 Zakrzewicz A, Secomb TW, Pries AR. Angioadaptation: keeping the vascular system in shape. News in Physiological Sciences : An International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society. 17: 197-201. PMID 12270956 DOI: 10.1152/Nips.01395.2001  0.401
2002 Pries AR, Secomb TW. Structural adaptation of microvascular networks and development of hypertension. Microcirculation (New York, N.Y. : 1994). 9: 305-14. PMID 12152106 DOI: 10.1038/Sj.Mn.7800144  0.432
2002 Secomb TW, Hsu R, Pries AR. Blood flow and red blood cell deformation in nonuniform capillaries: Effects of the endothelial surface layer Microcirculation. 9: 189-196. PMID 12080416 DOI: 10.1038/Sj.Mn.7800132  0.465
2002 Kavanagh BD, Secomb TW, Hsu R, Lin PS, Venitz J, Dewhirst MW. A theoretical model for the effects of reduced hemoglobin-oxygen affinity on tumor oxygenation. International Journal of Radiation Oncology, Biology, Physics. 53: 172-9. PMID 12007957 DOI: 10.1016/S0360-3016(02)02740-2  0.339
2001 Pries AR, Reglin B, Secomb TW. Structural adaptation of vascular networks: Role of the pressure response Hypertension. 38: 1476-1479. PMID 11751739 DOI: 10.1161/Hy1201.100592  0.388
2001 Li X, Su M, West CA, He C, Swanso SJ, Secomb TW, Mentzer SJ. Effect of shear stress on efferent lymph-derived lymphocytes in contact with activated endothelial monolayers. In Vitro Cellular & Developmental Biology. Animal. 37: 599-605. PMID 11710437 DOI: 10.1290/1071-2690(2001)037<0599:Eossoe>2.0.Co;2  0.394
2001 McGuire BJ, Secomb TW. A theoretical model for oxygen transport in skeletal muscle under conditions of high oxygen demand. Journal of Applied Physiology (Bethesda, Md. : 1985). 91: 2255-65. PMID 11641369 DOI: 10.1152/Jappl.2001.91.5.2255  0.787
2001 Snyder SA, Lanzen JL, Braun RD, Rosner G, Secomb TW, Biaglow J, Brizel DM, Dewhirst MW. Simultaneous administration of glucose and hyperoxic gas achieves greater improvement in tumor oxygenation than hyperoxic gas alone International Journal of Radiation Oncology Biology Physics. 51: 494-506. PMID 11567826 DOI: 10.1016/S0360-3016(01)01654-6  0.35
2001 West CA, He C, Su M, Secomb TW, Konerding MA, Young AJ, Mentzer SJ. Focal topographic changes in inflammatory microcirculation associated with lymphocyte slowing and transmigration. American Journal of Physiology. Heart and Circulatory Physiology. 281: H1742-50. PMID 11557566 DOI: 10.1152/Ajpheart.2001.281.4.H1742  0.307
2001 Pries AR, Reglin B, Secomb TW. Structural adaptation of microvascular networks: Functional roles of adaptive responses American Journal of Physiology - Heart and Circulatory Physiology. 281: H1015-H1025. PMID 11514266 DOI: 10.1152/Ajpheart.2001.281.3.H1015  0.426
2001 Secomb TW, Hsu R, Pries AR. Motion of red blood cells in a capillary with an endothelial surface layer: Effect of flow velocity American Journal of Physiology - Heart and Circulatory Physiology. 281: H629-H636. PMID 11454566 DOI: 10.1152/Ajpheart.2001.281.2.H629  0.471
2001 McGuire BJ, Secomb TW. A theoretical model for oxygen transport in skeletal muscle: Factors determining maximal oxygen consumption American Society of Mechanical Engineers, Bioengineering Division (Publication) Bed. 50: 457-458.  0.768
2000 Pries AR, Secomb TW. Microvascular adaptation - Regulation, coordination and function Zeitschrift Fur Kardiologie. 89: 117-120. PMID 11151780 DOI: 10.1007/Pl00022846  0.428
2000 Pries AR, Secomb TW. Microcirculatory network structures and models Annals of Biomedical Engineering. 28: 916-921. PMID 11144675 DOI: 10.1114/1.1308495  0.309
2000 Dewhirst MW, Klitzman B, Braun RD, Brizel DM, Haroon ZA, Secomb TW. Review of methods used to study oxygen transport at the microcirculatory level International Journal of Cancer. 90: 237-255. PMID 11091348 DOI: 10.1002/1097-0215(20001020)90:5<237::Aid-Ijc1>3.0.Co;2-T  0.342
2000 Pries AR, Secomb TW, Gaehtgens P. The endothelial surface layer Pflugers Archiv European Journal of Physiology. 440: 653-666. PMID 11007304 DOI: 10.1007/S004240000307  0.399
2000 Secomb TW, Hsu R, Beamer NB, Coull BM. Theoretical simulation of oxygen transport to brain by networks of microvessels: Effects of oxygen supply and demand on tissue hypoxia Microcirculation. 7: 237-247. PMID 10963629 DOI: 10.1111/J.1549-8719.2000.Tb00124.X  0.425
2000 El-Kareh AW, Secomb TW. A model for red blood cell motion in bifurcating microvessels International Journal of Multiphase Flow. 26: 1545-1564. DOI: 10.1016/S0301-9322(99)00096-8  0.436
1999 Gillies RJ, Schornack PA, Secomb TW, Raghunand N. Causes and Effects of Heterogeneous Perfusion in Tumors Neoplasia. 1: 197-207. PMID 10935474 DOI: 10.1038/Sj.Neo.7900037  0.391
1999 Pries AR, Secomb TW, Gaehtgens P. Structural autoregulation of terminal vascular beds: Vascular adaptation and development of hypertension Hypertension. 33: 153-161. PMID 9931096 DOI: 10.1161/01.Hyp.33.1.153  0.468
1998 Secomb TW, Hsu R, Braun RD, Ross JR, Gross JF, Dewhirst MW. Theoretical simulation of oxygen transport to tumors by three- dimensional networks of microvessels Advances in Experimental Medicine and Biology. 454: 629-634. PMID 9889943 DOI: 10.1007/978-1-4615-4863-8_74  0.404
1998 Pries AR, Secomb TW, Gaehtgens P. Structural adaptation and stability of microvascular networks: theory and simulations. The American Journal of Physiology. 275: H349-60. PMID 9683420 DOI: 10.1152/Ajpheart.1998.275.2.H349  0.408
1998 Pries AR, Secomb TW, Sperandio M, Gaehtgens P. Blood flow resistance during hemodilution: Effect of plasma composition Cardiovascular Research. 37: 225-235. PMID 9539877 DOI: 10.1016/S0008-6363(97)00226-5  0.363
1998 Secomb TW, Hsu R, Pries AR. A model for red blood cell motion in glycocalyx-lined capillaries American Journal of Physiology - Heart and Circulatory Physiology. 274: H1016-H1022. PMID 9530216 DOI: 10.1152/Ajpheart.1998.274.3.H1016  0.437
1997 Secomb TW, Hsu R. Resistance to blood flow in nonuniform capillaries Microcirculation. 4: 421-427. PMID 9431510 DOI: 10.3109/10739689709146806  0.456
1997 Pries AR, Secomb TW, Jacobs H, Sperandio M, Osterloh K, Gaehtgens P. Microvascular blood flow resistance: Role of endothelial surface layer American Journal of Physiology - Heart and Circulatory Physiology. 273: H2272-H2279. PMID 9374763 DOI: 10.1152/Ajpheart.1997.273.5.H2272  0.446
1997 Pries AR, Secomb TW. Resistance to blood flow in vivo: From Poiseuille to the 'in vivo viscosity law' Biorheology. 34: 369-373. DOI: 10.1016/S0006-355X(98)00011-0  0.401
1997 Secomb TW, Hsu R. Models for blood flow in capillaries: Effects of wall irregularity and glycocalyx American Society of Mechanical Engineers, Bioengineering Division (Publication) Bed. 35: 369-370.  0.356
1996 Secomb TW, Hsu R. Motion of red blood cells in capillaries with variable cross-sections Journal of Biomechanical Engineering. 118: 538-544. PMID 8950658 DOI: 10.1115/1.2796041  0.452
1996 Pries AR, Secomb TW, Gaehtgens P. Biophysical aspects of blood flow in the microvasculature Cardiovascular Research. 32: 654-667. PMID 8915184 DOI: 10.1016/S0008-6363(96)00065-X  0.481
1996 Secomb TW, Hsu R. Analysis of red blood cell motion through cylindrical micropores: Effects of cell properties Biophysical Journal. 71: 1095-1101. PMID 8842246 DOI: 10.1016/S0006-3495(96)79311-6  0.377
1996 Pries AR, Secomb TW, Gaehtgens P. Relationship between structural and hemodynamic heterogeneity in microvascular networks American Journal of Physiology - Heart and Circulatory Physiology. 270: H545-H553. PMID 8779829 DOI: 10.1152/Ajpheart.1996.270.2.H545  0.318
1996 Dewhirst MW, Kimura H, Rehmus SW, Braun RD, Papahadjopoulos D, Hong K, Secomb TW. Microvascular studies on the origins of perfusion-limited hypoxia The British Journal of Cancer. Supplement. 27: S247-251. PMID 8763890  0.35
1996 El-Kareh AW, Secomb TW. Stokes flow impinging on a spherical cap on a plane wall Quarterly Journal of Mechanics and Applied Mathematics. 49: 179-193. DOI: 10.1093/Qjmam/49.2.179  0.378
1995 Secomb TW, Hsu R. Red blood cell mechanics and functional capillary density International Journal of Microcirculation, Clinical and Experimental / Sponsored by the European Society For Microcirculation. 15: 250-254. PMID 8852623 DOI: 10.1159/000179026  0.449
1995 Secomb TW. Mechanics of blood flow in the microcirculation Symposia of the Society For Experimental Biology. 49: 305-321. PMID 8571232  0.391
1995 Secomb TW, Hsu R, Ong ET, Gross JF, Dewhirst MW. Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors Acta Oncologica. 34: 313-316. PMID 7779415 DOI: 10.3109/02841869509093981  0.456
1995 Pries AR, Secomb TW, Gaehtgens P. Design principles of vascular beds Circulation Research. 77: 1017-1023. PMID 7554136 DOI: 10.1161/01.Res.77.5.1017  0.385
1995 Pries AR, Secomb TW, Gaehtgens P. Structure and hemodynamics of microvascular networks: Heterogeneity and correlations American Journal of Physiology - Heart and Circulatory Physiology. 269: H1713-H1722. PMID 7503269 DOI: 10.1152/Ajpheart.1995.269.5.H1713  0.387
1995 SECOMB T, HSU R. F113. Analysis of motion of red blood cells and resistance to blood flow in non-uniform capillaries Biorheology. 32: 283-283. DOI: 10.1016/0006-355X(95)92226-Z  0.4
1995 SECOMB T, ELKAREH A. S17.6. Models for slow blood flow in narrow tubes; Effects of aggregation and sedimentation of flow resistance Biorheology. 32: 169-169. DOI: 10.1016/0006-355X(95)92044-B  0.402
1995 Secomb TW, Hsu R. Simulation of oxygen transport to skeletal muscle by microvascular networks American Society of Mechanical Engineers, Bioengineering Division (Publication) Bed. 29: 193-194.  0.346
1994 Secomb TW, Hsu R. Simulation of O2 transport in skeletal muscle: Diffusive exchange between arterioles and capillaries American Journal of Physiology - Heart and Circulatory Physiology. 267: H1214-H1221. PMID 8092288 DOI: 10.1152/Ajpheart.1994.267.3.H1214  0.466
1994 Pries AR, Secomb TW, Geßner T, Sperandio MB, Gross JF, Gaehtgens P. Resistance to blood flow in microvessels in vivo Circulation Research. 75: 904-915. PMID 7923637 DOI: 10.1161/01.Res.75.5.904  0.453
1994 Secomb TW, El-Kareh AW. A model for motion and sedimentation of cylindrical red-cell aggregates during slow blood flow in narrow horizontal tubes Journal of Biomechanical Engineering. 116: 243-249. PMID 7799623 DOI: 10.1115/1.2895726  0.383
1993 Secomb TW, Hsu R, Dewhirst MW, Klitzman B, Gross JF. Analysis of oxygen transport to tumor tissue by microvascular networks International Journal of Radiation Oncology, Biology, Physics. 25: 481-489. PMID 8436527 DOI: 10.1016/0360-3016(93)90070-C  0.45
1993 Secomb TW, El-Kareh AW. Slow blood flow in narrow tubes; effects of aggregation asymmetry and sedimentation American Society of Mechanical Engineers, Bioengineering Division (Publication) Bed. 26: 381-384.  0.316
1992 Hsu R, Secomb TW. Analysis of oxygen exchange between arterioles and surrounding capillary- perfused tissue Journal of Biomechanical Engineering. 114: 227-231. PMID 1602766 DOI: 10.1115/1.2891376  0.444
1992 Dewhirst MW, Vinuya RZ, Ong ET, Klitzman B, Rosner G, Secomb TW, Gross JF. Effects of bradykinin on the hemodynamics of tumor and granulating normal tissue microvasculature Radiation Research. 130: 345-354. PMID 1594761 DOI: 10.2307/3578380  0.393
1992 Dewhirst MW, Ong ET, Klitzman B, Secomb TW, Vinuya RZ, Dodge R, Brizel D, Gross JF. Perivascular oxygen tensions in a transplantable mammary tumor growing in a dorsal flap window chamber Radiation Research. 130: 171-182. PMID 1574573 DOI: 10.2307/3578274  0.405
1992 Dewhirst MW, Ong ET, Madwed D, Klitzman B, Secomb T, Brizel D, Bonaventura J, Rosner G, Kavanagh B, Edwards J, Gross J. Effects of the calcium channel blocker flunarizine on the hemodynamics and oxygenation of tumor microvasculature Radiation Research. 132: 61-68. PMID 1410275 DOI: 10.2307/3578334  0.422
1992 Halpern D, Secomb TW. The squeezing of red blood cells through parallel-sided channels with near-minimal widths Journal of Fluid Mechanics. 244: 307-322. DOI: 10.1017/S0022112092003082  0.376
1992 Secomb TW, Hsu R, Dewhirst MW. Models for oxygen exchange between microvascular networks and surrounding tissue American Society of Mechanical Engineers, Heat Transfer Division, (Publication) Htd. 231: 121-127.  0.305
1991 Secomb TW. Red blood cell mechanics and capillary blood rheology Cell Biophysics. 18: 231-251. PMID 1726534 DOI: 10.1007/BF02989816  0.369
1991 Halpern D, Secomb TW. Viscous motion of disk-shaped particles through parallel-sided channels with near-minimal widths Journal of Fluid Mechanics. 231: 545-560. DOI: 10.1017/S0022112091003506  0.327
1990 Dewhirst MW, Oliver R, Tso CY, Gustafson C, Secomb T, Gross JF. Heterogeneity in tumor microvascular response to radiation. International Journal of Radiation Oncology, Biology, Physics. 18: 559-68. PMID 2318688 DOI: 10.1016/0360-3016(90)90061-N  0.334
1990 Pries AR, Secomb TW, Gaehtgens P, Gross JF. Blood flow in microvascular networks. Experiments and simulation Circulation Research. 67: 826-834. PMID 2208609 DOI: 10.1161/01.Res.67.4.826  0.459
1990 Sugihara-Seki M, Secomb TW, Skalak R. Two-dimensional analysis of two-file flow of red cells along capillaries. Microvascular Research. 40: 379-93. PMID 2084502 DOI: 10.1016/0026-2862(90)90034-O  0.385
1989 Dewhirst MW, Tso CY, Oliver R, Gustafson CS, Secomb TW, Gross JF. Morphologic and hemodynamic comparison of tumor and healing normal tissue microvasculature International Journal of Radiation Oncology, Biology, Physics. 17: 91-99. PMID 2745213 DOI: 10.1016/0360-3016(89)90375-1  0.344
1989 Hsu R, Secomb TW. Motion of nonaxisymmetric red blood cells in cylindrical capillaries Journal of Biomechanical Engineering. 111: 147-151. PMID 2733409 DOI: 10.1115/1.3168356  0.402
1989 Murata T, Secomb TW. Effects of aggregation on the flow properties of red blood cell suspensions in narrow vertical tubes Biorheology. 26: 247-259. PMID 2605331 DOI: 10.3233/Bir-1989-26211  0.421
1989 Hsu R, Secomb TW. A Green's function method for analysis of oxygen delivery to tissue by microvascular networks Mathematical Biosciences. 96: 61-78. PMID 2520192 DOI: 10.1016/0025-5564(89)90083-7  0.396
1989 Secomb TW. Squeezing of red blood cells through capillaries with near-minimal diameters Journal of Fluid Mechanics. 203: 381-400. DOI: 10.1017/S0022112089001503  0.422
1988 Secomb TW, Hsu R. Analysis of oxygen delivery to tissue by microvascular networks Advances in Experimental Medicine and Biology. 222: 95-103. PMID 3364305 DOI: 10.1007/978-1-4615-9510-6_11  0.415
1988 Secomb TW. Interaction between bending and tension forces in bilayer membranes Biophysical Journal. 54: 743-746. PMID 3224154 DOI: 10.1016/S0006-3495(88)83010-8  0.324
1988 Murata T, Secomb TW. Effects of shear rate on rouleau formation in simple shear flow Biorheology. 25: 113-122. PMID 3196807 DOI: 10.3233/Bir-1988-251-218  0.32
1987 Secomb TW. Flow-dependent rheological properties of blood in capillaries Microvascular Research. 34: 46-58. PMID 3657604 DOI: 10.1016/0026-2862(87)90078-1  0.464
1986 Secomb TW, Skalak R, Ozkaya N, Gross JF. FLOW OF AXISYMMETRIC RED BLOOD CELLS IN NARROW CAPILLARIES. Journal of Fluid Mechanics. 163: 405-423. DOI: 10.1017/S0022112086002355  0.316
1986 Fleischman GJ, Secomb TW, Gross JF. The interaction of extravascular pressure fields and fluid exchange in capillary networks Mathematical Biosciences. 82: 141-151. DOI: 10.1016/0025-5564(86)90134-3  0.34
1986 Fleischman GJ, Secomb TW, Gross JF. Effect of extravascular pressure gradients on capillary fluid exchange Mathematical Biosciences. 81: 145-164. DOI: 10.1016/0025-5564(86)90114-8  0.365
1985 Secomb T, Gross J. Red blood cell mechanics and blood flow in narrow capillaries Journal of Biomechanics. 18: 240. DOI: 10.1016/0021-9290(85)90263-5  0.341
1983 Secomb TW, Gross JF. Flow of red blood cells in narrow capillaries: role of membrane tension International Journal of Microcirculation, Clinical and Experimental / Sponsored by the European Society For Microcirculation. 2: 229-240. PMID 6678849  0.349
1983 Secomb TW, Chien S, Jan KM, Skalak R. The bulk rheology of close-packed red blood cells in shear flow. Biorheology. 20: 295-309. PMID 6626714 DOI: 10.3233/Bir-1983-20304  0.421
1983 Secomb TW, Fischer TM, Skalak R. The motion of close-packed red blood cells in shear flow. Biorheology. 20: 283-94. PMID 6626713 DOI: 10.3233/Bir-1983-20303  0.39
1983 Stephanoff KD, Pedley TJ, Lawrence CJ, Secomb TW. Fluid flow along a channel with an asymmetric oscillating constriction Nature. 305: 692-695. DOI: 10.1038/305692A0  0.347
1982 Secomb TW, Skalak R. A two-dimensional model for capillary flow of an asymmetric cell. Microvascular Research. 24: 194-203. PMID 7176938 DOI: 10.1016/0026-2862(82)90056-5  0.429
1982 Secomb TW, Skalak R. SURFACE FLOW OF VISCOELASTIC MEMBRANES IN VISCOUS FLUIDS Quarterly Journal of Mechanics and Applied Mathematics. 35: 233-247. DOI: 10.1093/Qjmam/35.2.233  0.316
1981 Skalak R, Keller SR, Secomb TW. Mechanics of blood flow. Journal of Biomechanical Engineering. 103: 102-15. PMID 7024641 DOI: 10.1115/1.3138253  0.449
1979 Secomb TW, Rosenblat S. Torsional oscillations of a non-Newtonian fluid with a free surface Journal of Fluid Mechanics. 93: 767-780. DOI: 10.1017/S0022112079002020  0.343
1978 Secomb TW. Flow in a channel with pulsating walls Journal of Fluid Mechanics. 88: 273-288. DOI: 10.1017/S0022112078002104  0.38
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