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Frank Kirchhoff - Publications

Affiliations: 
Max-Planck-Institute for Experimental Medicine, Göttingen, Germany 
Area:
neuroglia, glia, astrocytes, oligodendrocytes, neurogenetics, in vivo imaging
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286 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2025 Fang LP, Lin CH, Medlej Y, Zhao R, Chang HF, Guo Q, Wu Z, Su Y, Zhao N, Gobbo D, Wyatt A, Wahl V, Fiore F, Tu SM, Boehm U, ... ... Kirchhoff F, et al. Oligodendrocyte precursor cells facilitate neuronal lysosome release. Nature Communications. 16: 1175. PMID 39885146 DOI: 10.1038/s41467-025-56484-8  0.353
2020 Bosso M, Prelli Bozzo C, Hotter D, Volcic M, Stürzel CM, Rammelt A, Ni Y, Urban S, Becker M, Schelhaas M, Wittmann S, Christensen MH, Schmidt FI, Gramberg T, Sparrer KMJ, ... ... Kirchhoff F, et al. Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells. Plos Pathogens. 16: e1008752. PMID 32760121 DOI: 10.1371/Journal.Ppat.1008752  0.378
2020 Volcic M, Sparrer KMJ, Koepke L, Hotter D, Sauter D, Stürzel CM, Scherer M, Stamminger T, Hofmann TG, Arhel NJ, Wiesmüller L, Kirchhoff F. Vpu modulates DNA repair to suppress innate sensing and hyper-integration of HIV-1. Nature Microbiology. PMID 32690953 DOI: 10.1038/S41564-020-0753-6  0.356
2020 Hopfensperger K, Richard J, Stürzel CM, Bibollet-Ruche F, Apps R, Leoz M, Plantier JC, Hahn BH, Finzi A, Kirchhoff F, Sauter D. Convergent Evolution of HLA-C Downmodulation in HIV-1 and HIV-2. Mbio. 11. PMID 32665270 DOI: 10.1128/Mbio.00782-20  0.391
2020 Nchioua R, Bosso M, Kmiec D, Kirchhoff F. Cellular Factors Targeting HIV-1 Transcriptionand Viral RNA Transcripts. Viruses. 12. PMID 32365692 DOI: 10.3390/V12050495  0.355
2020 Groß R, Bauer R, Krüger F, Rücker-Braun E, Olari LR, Ständker L, Preising N, Rodríguez AA, Conzelmann C, Gerbl F, Sauter D, Kirchhoff F, Hagemann B, Gačanin J, Weil T, et al. A Placenta Derived C-Terminal Fragment of β-Hemoglobin With Combined Antibacterial and Antiviral Activity. Frontiers in Microbiology. 11: 508. PMID 32328038 DOI: 10.3389/Fmicb.2020.00508  0.313
2020 Mesner D, Hotter D, Kirchhoff F, Jolly C. Loss of Nef-mediated CD3 down-regulation in the HIV-1 lineage increases viral infectivity and spread. Proceedings of the National Academy of Sciences of the United States of America. PMID 32179688 DOI: 10.1073/Pnas.1921135117  0.419
2020 Castro-Gonzalez S, Shi Y, Colomer-Lluch M, Song Y, Mowery K, Almodovar S, Bansal A, Kirchhoff F, Sparrer K, Liang C, Serra-Moreno R. HIV-1 Nef counteracts autophagy restriction by enhancing the association between BECN1 and its inhibitor BCL2 in a PRKN-dependent manner. Autophagy. 1-25. PMID 32097085 DOI: 10.1080/15548627.2020.1725401  0.389
2020 Joas S, Sauermann U, Roshani B, Klippert A, Daskalaki M, Mätz-Rensing K, Stolte-Leeb N, Heigele A, Tharp GK, Gupta PM, Nelson S, Bosinger S, Parodi L, Giavedoni L, Silvestri G, ... ... Kirchhoff F, et al. Nef-Mediated CD3-TCR Downmodulation Dampens Acute Inflammation and Promotes SIV Immune Evasion. Cell Reports. 30: 2261-2274.e7. PMID 32075764 DOI: 10.1016/J.Celrep.2020.01.069  0.367
2020 Prévost J, Edgar CR, Richard J, Trothen SM, Jacob RA, Mumby MJ, Pickering S, Dubé M, Kaufmann DE, Kirchhoff F, Neil SJD, Finzi A, Dikeakos JD. HIV-1 Vpu downregulates Tim-3 from the surface of infected CD4 T cells. Journal of Virology. PMID 31941771 DOI: 10.1128/Jvi.01999-19  0.399
2020 Kmiec D, Nchioua R, Sherrill-Mix S, Stürzel CM, Heusinger E, Braun E, Gondim MVP, Hotter D, Sparrer KMJ, Hahn BH, Sauter D, Kirchhoff F. CpG Frequency in the 5' Third of the Gene Determines Sensitivity of Primary HIV-1 Strains to the Zinc-Finger Antiviral Protein. Mbio. 11. PMID 31937644 DOI: 10.1128/Mbio.02903-19  0.379
2019 Schäfer I, Kaisler J, Scheller A, Kirchhoff F, Haghikia A, Faissner A. Conditional Deletion of LRP1 Leads to Progressive Loss of Recombined NG2-Expressing Oligodendrocyte Precursor Cells in a Novel Mouse Model. Cells. 8. PMID 31801252 DOI: 10.3390/Cells8121550  0.361
2019 Abdulhaqq SA, Martinez M, Kang G, Rodriguez IV, Nichols SM, Beaumont D, Joseph J, Azzoni L, Yin X, Wise M, Weiner D, Liu Q, Foulkes A, Münch J, Kirchhoff F, et al. Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques. Nature Communications. 10: 3753. PMID 31434895 DOI: 10.1038/S41467-019-11814-5  0.37
2019 Thans TVS, Akko JI, Niehrs A, Garcia-Beltran WF, Richert L, Stürzel CM, Ford CT, Li H, Ochsenbauer C, Kappes JC, Hahn BH, Kirchhoff F, Martrus G, Sauter D, Altfeld M, et al. Primary HIV-1 strains use Nef to downmodulate HLA-E surface expression. Journal of Virology. PMID 31375574 DOI: 10.1128/Jvi.00719-19  0.375
2019 Smith N, Rodero MP, Bekaddour N, Bondet V, Ruiz-Blanco YB, Harms M, Mayer B, Badder-Meunier B, Quartier P, Bodemer C, Baudouin V, Dieudonné Y, Kirchhoff F, Sanchez Garcia E, Charbit B, et al. Control of TLR7-mediated type I IFN signaling in pDCs through CXCR4 engagement-A new target for lupus treatment. Science Advances. 5: eaav9019. PMID 31309143 DOI: 10.1126/Sciadv.Aav9019  0.315
2019 Prévost J, Pickering S, Mumby MJ, Medjahed H, Gendron-Lepage G, Delgado GG, Dirk BS, Dikeakos JD, Stürzel CM, Sauter D, Kirchhoff F, Bibollet-Ruche F, Hahn BH, Dubé M, Kaufmann DE, et al. Upregulation of BST-2 by Type I Interferons Reduces the Capacity of Vpu To Protect HIV-1-Infected Cells from NK Cell Responses. Mbio. 10. PMID 31213558 DOI: 10.1128/Mbio.01113-19  0.395
2019 Hotter D, Bosso M, Jønsson KL, Krapp C, Stürzel CM, Das A, Littwitz-Salomon E, Berkhout B, Russ A, Wittmann S, Gramberg T, Zheng Y, Martins LJ, Planelles V, Jakobsen MR, ... ... Kirchhoff F, et al. IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation. Cell Host & Microbe. PMID 31175045 DOI: 10.1016/J.Chom.2019.05.002  0.361
2019 Yamasoba D, Sato K, Ichinose T, Imamura T, Koepke L, Joas S, Reith E, Hotter D, Misawa N, Akaki K, Uehata T, Mino T, Miyamoto S, Noda T, Yamashita A, ... ... Kirchhoff F, et al. N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation. Nature Microbiology. PMID 31133753 DOI: 10.1038/S41564-019-0460-3  0.391
2019 Braun E, Hotter D, Koepke L, Zech F, Groß R, Sparrer KMJ, Müller JA, Pfaller CK, Heusinger E, Wombacher R, Sutter K, Dittmer U, Winkler M, Simmons G, Jakobsen MR, ... ... Kirchhoff F, et al. Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins. Cell Reports. 27: 2092-2104.e10. PMID 31091448 DOI: 10.1016/J.Celrep.2019.04.063  0.368
2019 Grundmann D, Loris E, Maas Omlor S, Huang W, Scheller A, Kirchhoff F, Schäfer KH. Enteric glia - S100, GFAP and beyond. Anatomical Record (Hoboken, N.J. : 2007). PMID 30951262 DOI: 10.1002/Ar.24128  0.348
2019 Huang W, Guo Q, Bai X, Scheller A, Kirchhoff F. Early embryonic NG2 glia are exclusively gliogenic and do not generate neurons in the brain. Glia. PMID 30724411 DOI: 10.1002/Glia.23590  0.31
2019 Langer S, Hammer C, Hopfensperger K, Klein L, Hotter D, De Jesus PD, Herbert KM, Pache L, Smith N, van der Merwe JA, Chanda SK, Fellay J, Kirchhoff F, Sauter D. HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses. Elife. 8. PMID 30717826 DOI: 10.7554/Elife.41930  0.35
2019 Sauter D, Kirchhoff F. Key Viral Adaptations Preceding the AIDS Pandemic. Cell Host & Microbe. 25: 27-38. PMID 30629915 DOI: 10.1016/J.Chom.2018.12.002  0.345
2019 Kirchhoff F, Johnson WE. Decision letter: Rhabdo-immunodeficiency virus, a murine model of acute HIV-1 infection Elife. DOI: 10.7554/Elife.49875.Sa1  0.35
2019 Langer S, Hammer C, Hopfensperger K, Klein L, Hotter D, Jesus PDD, Herbert KM, Pache L, Smith N, Merwe JAvd, Chanda SK, Fellay J, Kirchhoff F, Sauter D. Author response: HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses Elife. DOI: 10.7554/Elife.41930.021  0.303
2019 Kmiec D, Srinivasachar S, Kirchhoff F. Potential roles of Nef and Vpu in HIV-1 latency Future Virology. 14: 227-236. DOI: 10.2217/Fvl-2018-0214  0.343
2018 Kmiec D, Akbil B, Ananth S, Hotter D, Sparrer K, Stürzel CM, Trautz B, Ayouba A, Peeters M, Yao Z, Stagljar I, Passos V, Zillinger T, Goffinet C, Sauter D, ... ... Kirchhoff F, et al. SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue. Plos Pathogens. 14: e1007269. PMID 30125328 DOI: 10.1371/Journal.Ppat.1007269  0.404
2018 Morris KL, Buffalo CZ, Stürzel CM, Heusinger E, Kirchhoff F, Ren X, Hurley JH. HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation. Cell. 174: 659-671.e14. PMID 30053425 DOI: 10.1016/J.Cell.2018.07.004  0.343
2018 Heusinger E, Deppe K, Sette P, Krapp C, Kmiec D, Kluge SF, Marx PA, Apetrei C, Kirchhoff F, Sauter D. Preadaptation of SIVsmm facilitated Env-mediated counteraction of human tetherin by HIV-2. Journal of Virology. PMID 29976668 DOI: 10.1128/Jvi.00276-18  0.393
2018 Müller JA, Glöckle A, Gawanbacht A, Geyer M, Münch J, Kirchhoff F. Reduced Susceptibility to VIRIP-based HIV-1 Entry Inhibitors has a High Genetic Barrier and Severe Fitness Costs. Journal of Virology. PMID 29925662 DOI: 10.1128/Jvi.00733-18  0.372
2018 Lodermeyer V, Ssebyatika G, Passos V, Ponnurangam A, Malassa A, Ewald E, Stürzel CM, Kirchhoff F, Rotger M, Falk CS, Telenti A, Krey T, Goffinet C. The Antiviral Activity of the Cellular Glycoprotein LGALS3BP/90K is Species-Specific. Journal of Virology. PMID 29743357 DOI: 10.1128/Jvi.00226-18  0.337
2018 Joas S, Parrish EH, Gnanadurai CW, Lump E, Stürzel CM, Parrish NF, Learn GH, Sauermann U, Neumann B, Rensing KM, Fuchs D, Billingsley JM, Bosinger SE, Silvestri G, Apetrei C, ... ... Kirchhoff F, et al. Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity. Nature Communications. 9: 1371. PMID 29636452 DOI: 10.1038/S41467-018-03762-3  0.376
2018 Richard J, Prévost J, Baxter AE, von Bredow B, Ding S, Medjahed H, Delgado GG, Brassard N, Stürzel CM, Kirchhoff F, Hahn BH, Parsons MS, Kaufmann DE, Evans DT, Finzi A. Uninfected Bystander Cells Impact the Measurement of HIV-Specific Antibody-Dependent Cellular Cytotoxicity Responses. Mbio. 9. PMID 29559570 DOI: 10.1128/Mbio.00358-18  0.382
2018 Sauter D, Kirchhoff F. Multilayered and versatile inhibition of cellular antiviral factors by HIV and SIV accessory proteins. Cytokine & Growth Factor Reviews. PMID 29526437 DOI: 10.1016/J.Cytogfr.2018.02.005  0.354
2018 Yamada E, Nakaoka S, Klein L, Reith E, Langer S, Hopfensperger K, Iwami S, Schreiber G, Kirchhoff F, Koyanagi Y, Sauter D, Sato K. Human-Specific Adaptations in Vpu Conferring Anti-tetherin Activity Are Critical for Efficient Early HIV-1 Replication In Vivo. Cell Host & Microbe. 23: 110-120.e7. PMID 29324226 DOI: 10.1016/J.Chom.2017.12.009  0.397
2018 Palesch D, Bosinger SE, Tharp GK, Vanderford TH, Paiardini M, Chahroudi A, Johnson ZP, Kirchhoff F, Hahn BH, Norgren RB, Patel NB, Sodora DL, Dawoud RA, Stewart CB, Seepo SM, et al. Sooty mangabey genome sequence provides insight into AIDS resistance in a natural SIV host. Nature. 553: 77-81. PMID 29300007 DOI: 10.1038/Nature25140  0.34
2017 Hotter D, Kirchhoff F. Interferons and beyond: Induction of antiretroviral restriction factors. Journal of Leukocyte Biology. PMID 29345347 DOI: 10.1002/Jlb.3Mr0717-307R  0.322
2017 Barros LF, Bolaños JP, Bonvento G, Bouzier-Sore AK, Brown A, Hirrlinger J, Kasparov S, Kirchhoff F, Murphy AN, Pellerin L, Robinson MB, Weber B. Current technical approaches to brain energy metabolism. Glia. PMID 29110344 DOI: 10.1002/Glia.23248  0.543
2017 Darcis G, Van Driessche B, Bouchat S, Kirchhoff F, Van Lint C. Molecular Control of HIV and SIV Latency. Current Topics in Microbiology and Immunology. PMID 29071474 DOI: 10.1007/82_2017_74  0.376
2017 Mwimanzi F, Toyoda M, Mahiti M, Mann JK, Martin JN, Bangsberg D, Brockman MA, Goulder P, Kirchhoff F, Brumme ZL, Ndung'u T, Ueno T. Relative resistance of MHC-B to Nef-mediated downregulation is conserved among primate lentiviruses and influences antiviral T cell responses in HIV-1-infected individuals. Journal of Virology. PMID 29046444 DOI: 10.1128/Jvi.01409-17  0.37
2017 Kirchhoff F. Analysis of Functional NMDA Receptors in Astrocytes. Methods in Molecular Biology (Clifton, N.J.). 1677: 241-251. PMID 28986877 DOI: 10.1007/978-1-4939-7321-7_13  0.315
2017 Schwarz Y, Zhao N, Kirchhoff F, Bruns D. Astrocytes control synaptic strength by two distinct v-SNARE-dependent release pathways. Nature Neuroscience. PMID 28945220 DOI: 10.1038/Nn.4647  0.311
2017 Manrique S, Sauter D, Horenkamp FA, Lülf S, Yu H, Hotter D, Anand K, Kirchhoff F, Geyer M. Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3. Nature Communications. 8: 442. PMID 28874665 DOI: 10.1038/S41467-017-00481-Z  0.32
2017 Hotter D, Krabbe T, Reith E, Gawanbacht A, Rahm N, Ayouba A, Van Driessche B, Van Lint C, Peeters M, Kirchhoff F, Sauter D. Primate lentiviruses use at least three alternative strategies to suppress NF-κB-mediated immune activation. Plos Pathogens. 13: e1006598. PMID 28859166 DOI: 10.1371/Journal.Ppat.1006598  0.341
2017 Körner C, Simoneau CR, Schommers P, Granoff M, Ziegler M, Hölzemer A, Lunemann S, Chukwukelu J, Corleis B, Naranbhai V, Kwon DS, Scully EP, Jost S, Kirchhoff F, Carrington M, et al. HIV-1-Mediated Downmodulation of HLA-C Impacts Target Cell Recognition and Antiviral Activity of NK Cells. Cell Host & Microbe. 22: 111-119.e4. PMID 28704647 DOI: 10.1016/J.Chom.2017.06.008  0.35
2017 Scheller A, Bai X, Kirchhoff F. The Role of the Oligodendrocyte Lineage in Acute Brain Trauma. Neurochemical Research. PMID 28702713 DOI: 10.1007/S11064-017-2343-4  0.305
2017 Roan NR, Sandi-Monroy N, Kohgadai N, Usmani SM, Hamil KG, Neidleman J, Montano M, Ständker L, Röcker A, Cavrois M, Rosen J, Marson K, Smith JF, Pilcher CD, Gagsteiger F, ... ... Kirchhoff F, et al. Semen amyloids participate in spermatozoa selection and clearance. Elife. 6. PMID 28653619 DOI: 10.7554/Elife.24888  0.308
2017 Belkacemi T, Niermann A, Hofmann L, Wissenbach U, Birnbaumer L, Leidinger P, Backes C, Meese E, Keller A, Bai X, Scheller A, Kirchhoff F, Philipp SE, Weissgerber P, Flockerzi V, et al. TRPC1- and TRPC3-dependent Ca(2+) signaling in mouse cortical astrocytes affects injury-evoked astrogliosis in vivo. Glia. PMID 28636132 DOI: 10.1002/Glia.23180  0.307
2017 Richard J, Prévost J, von Bredow B, Ding S, Brassard N, Medjahed H, Coutu M, Melillo B, Bibollet-Ruche F, Hahn BH, Kaufmann DE, Smith AB, Sodroski J, Sauter D, Kirchhoff F, et al. BST-2 Expression Modulates Small CD4 Mimetic Sensitization of HIV-1-infected cells to ADCC. Journal of Virology. PMID 28331088 DOI: 10.1128/Jvi.00219-17  0.388
2017 Heusinger E, Kirchhoff F. Primate Lentiviruses Modulate NF-κB Activity by Multiple Mechanisms to Fine-Tune Viral and Cellular Gene Expression. Frontiers in Microbiology. 8: 198. PMID 28261165 DOI: 10.3389/Fmicb.2017.00198  0.384
2017 Mack K, Starz K, Sauter D, Langer S, Bibollet-Ruche F, Learn GH, Stürzel CM, Leoz M, Plantier JC, Geyer M, Hahn BH, Kirchhoff F. Efficient Vpu-mediated tetherin antagonism by an HIV-1 group O strain. Journal of Virology. PMID 28077643 DOI: 10.1128/Jvi.02177-16  0.381
2017 Riegger A, Chen C, Zirafi O, Daiss N, Mukherji D, Walter K, Tokura Y, Stöckle B, Kremer K, Kirchhoff F, Yuen Wah Ng D, Christian Hermann P, Münch J, Weil T. Synthesis of Peptide-Functionalized Poly(bis-sulfone) Copolymers Regulating HIV-1 Entry and Cancer Stem Cell Migration Acs Macro Letters. 6: 241-246. DOI: 10.1021/Acsmacrolett.7B00030  0.319
2016 Perea G, Gómez R, Mederos S, Covelo A, Ballesteros JJ, Schlosser L, Hernández-Vivanco A, Martín-Fernández M, Quintana R, Rayan A, Díez A, Fuenzalida M, Agarwal A, Bergles DE, Bettler B, ... ... Kirchhoff F, et al. Activity-dependent switch of GABAergic inhibition into glutamatergic excitation in astrocyte-neuron networks. Elife. 5. PMID 28012274 DOI: 10.7554/Elife.20362  0.442
2016 Sauter D, Kirchhoff F. IFITMs: Important Factors In Trans-Mission of HIV-1. Cell Host & Microbe. 20: 407-408. PMID 27736636 DOI: 10.1016/J.Chom.2016.09.009  0.361
2016 Vermeire J, Roesch F, Sauter D, Rua R, Hotter D, Van Nuffel A, Vanderstraeten H, Naessens E, Iannucci V, Landi A, Witkowski W, Baeyens A, Kirchhoff F, Verhasselt B. HIV Triggers a cGAS-Dependent, Vpu- and Vpr-Regulated Type I Interferon Response in CD4(+) T Cells. Cell Reports. 17: 413-424. PMID 27705790 DOI: 10.1016/J.Celrep.2016.09.023  0.408
2016 Heigele A, Kmiec D, Regensburger K, Langer S, Peiffer L, Stürzel CM, Sauter D, Peeters M, Pizzato M, Learn GH, Hahn BH, Kirchhoff F. The Potency of Nef-Mediated SERINC5 Antagonism Correlates with the Prevalence of Primate Lentiviruses in the Wild. Cell Host & Microbe. 20: 381-391. PMID 27631701 DOI: 10.1016/J.Chom.2016.08.004  0.375
2016 Schneider S, Gruart A, Grade S, Zhang Y, Kröger S, Kirchhoff F, Eichele G, Delgado García JM, Dimou L. Decrease in newly generated oligodendrocytes leads to motor dysfunctions and changed myelin structures that can be rescued by transplanted cells. Glia. PMID 27615452 DOI: 10.1002/Glia.23055  0.309
2016 Bego MG, Cong L, Mack K, Kirchhoff F, Cohen ÉA. Differential Control of BST2 restriction and Plasmacytoid Dendritic Cell Antiviral Response by Antagonists encoded by HIV-1 Group M and O Strains. Journal of Virology. PMID 27581991 DOI: 10.1128/Jvi.01131-16  0.366
2016 Kmiec D, Iyer SS, Stürzel CM, Sauter D, Hahn BH, Kirchhoff F. Vpu-Mediated Counteraction of Tetherin Is a Major Determinant of HIV-1 Interferon Resistance. Mbio. 7. PMID 27531907 DOI: 10.1128/Mbio.00934-16  0.399
2016 Grundmann D, Markwart F, Scheller A, Kirchhoff F, Schäfer KH. Phenotype and distribution pattern of nestin-GFP-expressing cells in murine myenteric plexus. Cell and Tissue Research. PMID 27519533 DOI: 10.1007/S00441-016-2476-9  0.325
2016 Scheller A, Kirchhoff F. Endocannabinoids and Heterogeneity of Glial Cells in Brain Function. Frontiers in Integrative Neuroscience. 10: 24. PMID 27458351 DOI: 10.3389/Fnint.2016.00024  0.342
2016 Saab AS, Tzvetavona ID, Trevisiol A, Baltan S, Dibaj P, Kusch K, Möbius W, Goetze B, Jahn HM, Huang W, Steffens H, Schomburg ED, Pérez-Samartín A, Pérez-Cerdá F, Bakhtiari D, ... ... Kirchhoff F, et al. Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism. Neuron. PMID 27292539 DOI: 10.1016/J.Neuron.2016.05.016  0.753
2016 Hotter D, Sauter D, Kirchhoff F. Guanylate binding protein 5: Impairing virion infectivity by targeting retroviral envelope glycoproteins. Small Gtpases. 1-7. PMID 27275775 DOI: 10.1080/21541248.2016.1189990  0.429
2016 Rudolph R, Jahn HM, Courjaret R, Messemer N, Kirchhoff F, Deitmer JW. The inhibitory input to mouse cerebellar Purkinje cells is reciprocally modulated by Bergmann glial P2Y1 and AMPA receptor signaling. Glia. PMID 27144942 DOI: 10.1002/Glia.22999  0.311
2016 Krapp C, Hotter D, Gawanbacht A, McLaren PJ, Kluge SF, Stürzel CM, Mack K, Reith E, Engelhart S, Ciuffi A, Hornung V, Sauter D, Telenti A, Kirchhoff F. Guanylate Binding Protein (GBP) 5 Is an Interferon-Inducible Inhibitor of HIV-1 Infectivity. Cell Host & Microbe. PMID 26996307 DOI: 10.1016/J.Chom.2016.02.019  0.391
2016 Perea G, Gómez R, Mederos S, Covelo A, Ballesteros JJ, Schlosser L, Hernández-Vivanco A, Martín-Fernández M, Quintana R, Rayan A, Díez A, Fuenzalida M, Agarwal A, Bergles DE, Bettler B, ... ... Kirchhoff F, et al. Author response: Activity-dependent switch of GABAergic inhibition into glutamatergic excitation in astrocyte-neuron networks Elife. DOI: 10.7554/Elife.20362.016  0.402
2016 Röcker A, Kirchhoff F, Münch J. Combating HIV: what the human peptidome offers Future Virology. 11: 167-170. DOI: 10.2217/Fvl.15.116  0.303
2015 Portilho DM, Fernandez J, Ringeard M, Machado AK, Boulay A, Mayer M, Müller-Trutwin M, Beignon AS, Kirchhoff F, Nisole S, Arhel NJ. Endogenous TRIM5α Function Is Regulated by SUMOylation and Nuclear Sequestration for Efficient Innate Sensing in Dendritic Cells. Cell Reports. PMID 26748714 DOI: 10.1016/J.Celrep.2015.12.039  0.329
2015 Ding S, Veillette M, Coutu M, Prévost J, Scharf L, Bjorkman PJ, Ferrari G, Robinson JE, Stürzel C, Hahn BH, Sauter D, Kirchhoff F, Lewis GK, Pazgier M, Finzi A. A Highly-Conserved Residue of the HIV-1-gp120 Inner Domain is Important for ADCC Responses Mediated by Anti-Cluster A Antibodies. Journal of Virology. PMID 26637462 DOI: 10.1128/Jvi.02779-15  0.314
2015 Sauter D, Kirchhoff F. HIV replication: a game of hide and sense. Current Opinion in Hiv and Aids. PMID 26628325 DOI: 10.1097/Coh.0000000000000233  0.336
2015 Buske C, Kirchhoff F, Münch J. EPI-X4, a novel endogenous antagonist of CXCR4. Oncotarget. PMID 26459389 DOI: 10.18632/Oncotarget.6037  0.341
2015 Heigele A, Joas S, Regensburger K, Kirchhoff F. Increased susceptibility of CD4+ T cells from elderly individuals to HIV-1 infection and apoptosis is associated with reduced CD4 and enhanced CXCR4 and FAS surface expression levels. Retrovirology. 12: 86. PMID 26452480 DOI: 10.1186/S12977-015-0213-1  0.387
2015 Tristão FS, Lazzarini M, Martin S, Amar M, Stühmer W, Kirchhoff F, Gomes LA, Lanfumey L, Prediger RD, Sepulveda JE, Del-Bel EA, Raisman-Vozari R. CX3CR1 Disruption Differentially Influences Dopaminergic Neuron Degeneration in Parkinsonian Mice Depending on the Neurotoxin and Route of Administration. Neurotoxicity Research. PMID 26403659 DOI: 10.1007/S12640-015-9557-5  0.302
2015 Heusinger E, Kluge SF, Kirchhoff F, Sauter D. Early Vertebrate Evolution of the Host Restriction Factor Tetherin. Journal of Virology. 89: 12154-65. PMID 26401043 DOI: 10.1128/Jvi.02149-15  0.309
2015 Jahn HM, Scheller A, Kirchhoff F. Genetic control of astrocyte function in neural circuits. Frontiers in Cellular Neuroscience. 9: 310. PMID 26347607 DOI: 10.3389/Fncel.2015.00310  0.326
2015 Lump E, Castellano LM, Meier C, Seeliger J, Erwin N, Sperlich B, Stürzel CM, Usmani S, Hammond RM, von Einem J, Gerold G, Kreppel F, Bravo-Rodriguez K, Pietschmann T, Holmes VM, ... ... Kirchhoff F, et al. A molecular tweezer antagonizes seminal amyloids and HIV infection. Elife. 4. PMID 26284498 DOI: 10.7554/Elife.05397  0.366
2015 McLaren PJ, Gawanbacht A, Pyndiah N, Krapp C, Hotter D, Kluge SF, Götz N, Heilmann J, Mack K, Sauter D, Thompson D, Perreaud J, Rausell A, Munoz M, Ciuffi A, ... Kirchhoff F, et al. Identification of potential HIV restriction factors by combining evolutionary genomic signatures with functional analyses. Retrovirology. 12: 41. PMID 25980612 DOI: 10.1186/S12977-015-0165-5  0.387
2015 Zirafi O, Kim KA, Ständker L, Mohr KB, Sauter D, Heigele A, Kluge SF, Wiercinska E, Chudziak D, Richter R, Moepps B, Gierschik P, Vas V, Geiger H, Lamla M, ... ... Kirchhoff F, et al. Discovery and characterization of an endogenous CXCR4 antagonist. Cell Reports. 11: 737-47. PMID 25921529 DOI: 10.1016/J.Celrep.2015.03.061  0.304
2015 Bächle SM, Sauter D, Sibitz S, Sandberg JK, Kirchhoff F, Moll M. Involvement of a C-terminal motif in the interference of primate lentiviral Vpu proteins with CD1d-mediated antigen presentation. Scientific Reports. 5: 9675. PMID 25872908 DOI: 10.1038/Srep09675  0.35
2015 Mlcochova P, Apolonia L, Kluge SF, Sridharan A, Kirchhoff F, Malim MH, Sauter D, Gupta RK. Immune evasion activities of accessory proteins Vpu, Nef and Vif are conserved in acute and chronic HIV-1 infection. Virology. 482: 72-8. PMID 25827531 DOI: 10.1016/J.Virol.2015.03.015  0.365
2015 Chen J, Tibroni N, Sauter D, Galaski J, Miura T, Alter G, Mueller B, Haller C, Walker BD, Kirchhoff F, Brumme ZL, Ueno T, Fackler OT. Modest attenuation of HIV-1 Vpu alleles derived from elite controller plasma. Plos One. 10: e0120434. PMID 25793728 DOI: 10.1371/Journal.Pone.0120434  0.401
2015 Kaltenmeier C, Gawanbacht A, Beyer T, Lindner S, Trzaska T, van der Merwe JA, Härter G, Grüner B, Fabricius D, Lotfi R, Schwarz K, Schütz C, Hönig M, Schulz A, Kern P, ... ... Kirchhoff F, et al. CD4+ T cell-derived IL-21 and deprivation of CD40 signaling favor the in vivo development of granzyme B-expressing regulatory B cells in HIV patients. Journal of Immunology (Baltimore, Md. : 1950). 194: 3768-77. PMID 25780036 DOI: 10.4049/Jimmunol.1402568  0.34
2015 Yu H, Khalid M, Heigele A, Schmökel J, Usmani SM, van der Merwe J, Münch J, Silvestri G, Kirchhoff F. Lentiviral Nef proteins manipulate T cells in a subset-specific manner. Journal of Virology. 89: 1986-2001. PMID 25505066 DOI: 10.1128/Jvi.03104-14  0.376
2015 Lump E, Castellano LM, Meier C, Seeliger J, Erwin N, Sperlich B, Stürzel CM, Usmani S, Hammond RM, Einem Jv, Gerold G, Kreppel F, Bravo-Rodriguez K, Pietschmann T, Holmes VM, ... ... Kirchhoff F, et al. Author response: A molecular tweezer antagonizes seminal amyloids and HIV infection Elife. DOI: 10.7554/Elife.05397.031  0.334
2014 Kluge SF, Mack K, Iyer SS, Pujol FM, Heigele A, Learn GH, Usmani SM, Sauter D, Joas S, Hotter D, Bibollet-Ruche F, Plenderleith LJ, Peeters M, Geyer M, Sharp PM, ... ... Kirchhoff F, et al. Nef proteins of epidemic HIV-1 group O strains antagonize human tetherin. Cell Host & Microbe. 16: 639-50. PMID 25525794 DOI: 10.1016/J.Chom.2014.10.002  0.35
2014 Zirafi O, Kim KA, Roan NR, Kluge SF, Müller JA, Jiang S, Mayer B, Greene WC, Kirchhoff F, Münch J. Semen enhances HIV infectivity and impairs the antiviral efficacy of microbicides. Science Translational Medicine. 6: 262ra157. PMID 25391483 DOI: 10.1126/Scitranslmed.3009634  0.366
2014 Klatt NR, Bosinger SE, Peck M, Richert-Spuhler LE, Heigele A, Gile JP, Patel N, Taaffe J, Julg B, Camerini D, Torti C, Martin JN, Deeks SG, Sinclair E, Hecht FM, ... ... Kirchhoff F, et al. Limited HIV infection of central memory and stem cell memory CD4+ T cells is associated with lack of progression in viremic individuals. Plos Pathogens. 10: e1004345. PMID 25167059 DOI: 10.1371/Journal.Ppat.1004345  0.35
2014 Münch J, Ständker L, Forssmann WG, Kirchhoff F. Discovery of modulators of HIV-1 infection from the human peptidome. Nature Reviews. Microbiology. 12: 715-22. PMID 25110191 DOI: 10.1038/Nrmicro3312  0.305
2014 Meier C, Weil T, Kirchhoff F, Münch J. Peptide nanofibrils as enhancers of retroviral gene transfer. Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology. 6: 438-51. PMID 24865496 DOI: 10.1002/Wnan.1275  0.302
2014 Roan NR, Liu H, Usmani SM, Neidleman J, Müller JA, Avila-Herrera A, Gawanbacht A, Zirafi O, Chu S, Dong M, Kumar ST, Smith JF, Pollard KS, Fändrich M, Kirchhoff F, et al. Liquefaction of semen generates and later degrades a conserved semenogelin peptide that enhances HIV infection. Journal of Virology. 88: 7221-34. PMID 24741080 DOI: 10.1128/Jvi.00269-14  0.375
2014 Usmani SM, Zirafi O, Müller JA, Sandi-Monroy NL, Yadav JK, Meier C, Weil T, Roan NR, Greene WC, Walther P, Nilsson KP, Hammarström P, Wetzel R, Pilcher CD, Gagsteiger F, ... ... Kirchhoff F, et al. Direct visualization of HIV-enhancing endogenous amyloid fibrils in human semen. Nature Communications. 5: 3508. PMID 24691351 DOI: 10.1038/Ncomms4508  0.334
2014 Huang W, Zhao N, Bai X, Karram K, Trotter J, Goebbels S, Scheller A, Kirchhoff F. Novel NG2-CreERT2 knock-in mice demonstrate heterogeneous differentiation potential of NG2 glia during development. Glia. 62: 896-913. PMID 24578301 DOI: 10.1002/Glia.22648  0.325
2014 Heigele A, Camerini D, van't Wout AB, Kirchhoff F. Viremic long-term nonprogressive HIV-1 infection is not associated with abnormalities in known Nef functions. Retrovirology. 11: 13. PMID 24495362 DOI: 10.1186/1742-4690-11-13  0.412
2014 Koppensteiner H, Höhne K, Gondim MV, Gobert FX, Widder M, Gundlach S, Heigele A, Kirchhoff F, Winkler M, Benaroch P, Schindler M. Lentiviral Nef suppresses iron uptake in a strain specific manner through inhibition of Transferrin endocytosis. Retrovirology. 11: 1. PMID 24383984 DOI: 10.1186/1742-4690-11-1  0.336
2014 Heigele A, Sauter D, Münch J, Kirchhoff F. HIV-1 accessory proteins: Nef. Methods in Molecular Biology (Clifton, N.J.). 1087: 115-23. PMID 24158818 DOI: 10.1007/978-1-62703-670-2_10  0.395
2014 Jahrsdörfer B, Kaltenmeier C, Gawanbacht A, Beyer T, Schütz C, Hönig M, Kirchhoff F, Schrezenmeier H. IL-21-Mediated Generation of Human Regulatory B Cells Occurs Independently of CD40 Signaling Blood. 124: 1413-1413. DOI: 10.1182/Blood.V124.21.1413.1413  0.315
2013 Münch J, Sauermann U, Yolamanova M, Raue K, Stahl-Hennig C, Kirchhoff F. Effect of semen and seminal amyloid on vaginal transmission of simian immunodeficiency virus. Retrovirology. 10: 148. PMID 24308721 DOI: 10.1186/1742-4690-10-148  0.31
2013 Schmökel J, Li H, Shabir A, Yu H, Geyer M, Silvestri G, Sodora DL, Hahn BH, Kirchhoff F. Link between primate lentiviral coreceptor usage and Nef function. Cell Reports. 5: 997-1009. PMID 24268781 DOI: 10.1016/J.Celrep.2013.10.028  0.326
2013 Palesch D, Kirchhoff F. First steps toward a globally effective HIV/AIDS vaccine. Cell. 155: 495-7. PMID 24243006 DOI: 10.1016/J.Cell.2013.10.012  0.325
2013 Van Nuffel A, Ariën KK, Stove V, Schindler M, O'Neill E, Schmökel J, Van de Walle I, Naessens E, Vanderstraeten H, Van Landeghem K, Taghon T, Pulkkinen K, Saksela K, Garcia JV, Fackler OT, ... Kirchhoff F, et al. Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms. Retrovirology. 10: 137. PMID 24237970 DOI: 10.1186/1742-4690-10-137  0.407
2013 Lodermeyer V, Suhr K, Schrott N, Kolbe C, Stürzel CM, Krnavek D, Münch J, Dietz C, Waldmann T, Kirchhoff F, Goffinet C. 90K, an interferon-stimulated gene product, reduces the infectivity of HIV-1. Retrovirology. 10: 111. PMID 24156545 DOI: 10.1186/1742-4690-10-111  0.364
2013 Hotter D, Sauter D, Kirchhoff F. Emerging role of the host restriction factor tetherin in viral immune sensing. Journal of Molecular Biology. 425: 4956-64. PMID 24075872 DOI: 10.1016/J.Jmb.2013.09.029  0.36
2013 Sauter D, Hotter D, Engelhart S, Giehler F, Kieser A, Kubisch C, Kirchhoff F. A rare missense variant abrogates the signaling activity of tetherin/BST-2 without affecting its effect on virus release. Retrovirology. 10: 85. PMID 23937976 DOI: 10.1186/1742-4690-10-85  0.39
2013 Frühbeis C, Fröhlich D, Kuo WP, Amphornrat J, Thilemann S, Saab AS, Kirchhoff F, Möbius W, Goebbels S, Nave KA, Schneider A, Simons M, Klugmann M, Trotter J, Krämer-Albers EM. Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication. Plos Biology. 11: e1001604. PMID 23874151 DOI: 10.1371/Journal.Pbio.1001604  0.756
2013 Bai X, Saab AS, Huang W, Hoberg IK, Kirchhoff F, Scheller A. Genetic background affects human glial fibrillary acidic protein promoter activity. Plos One. 8: e66873. PMID 23826164 DOI: 10.1371/Journal.Pone.0066873  0.758
2013 Hotter D, Kirchhoff F, Sauter D. HIV-1 Vpu does not degrade interferon regulatory factor 3. Journal of Virology. 87: 7160-5. PMID 23552418 DOI: 10.1128/Jvi.00526-13  0.362
2013 Bolduan S, Hubel P, Reif T, Lodermeyer V, Höhne K, Fritz JV, Sauter D, Kirchhoff F, Fackler OT, Schindler M, Schubert U. HIV-1 Vpu affects the anterograde transport and the glycosylation pattern of NTB-A. Virology. 440: 190-203. PMID 23528733 DOI: 10.1016/J.Virol.2013.02.021  0.386
2013 Kluge SF, Sauter D, Vogl M, Peeters M, Li Y, Bibollet-Ruche F, Hahn BH, Kirchhoff F. The transmembrane domain of HIV-1 Vpu is sufficient to confer anti-tetherin activity to SIVcpz and SIVgor Vpu proteins: cytoplasmic determinants of Vpu function. Retrovirology. 10: 32. PMID 23514615 DOI: 10.1186/1742-4690-10-32  0.358
2013 Yu H, Usmani SM, Borch A, Krämer J, Stürzel CM, Khalid M, Li X, Krnavek D, van der Ende ME, Osterhaus AD, Gruters RA, Kirchhoff F. The efficiency of Vpx-mediated SAMHD1 antagonism does not correlate with the potency of viral control in HIV-2-infected individuals. Retrovirology. 10: 27. PMID 23497283 DOI: 10.1186/1742-4690-10-27  0.389
2013 Kettenmann H, Kirchhoff F, Verkhratsky A. Microglia: new roles for the synaptic stripper. Neuron. 77: 10-8. PMID 23312512 DOI: 10.1016/J.Neuron.2012.12.023  0.302
2013 Frühbeis C, Fröhlich D, Kuo WP, Amphornrat J, Thilemann S, Saab AS, Kirchhoff F, Möbius W, Goebbels S, Nave K, Schneider A, Simons M, Klugmann M, Trotter J, Krämer-Albers E. Neuroprotective role of oligodendroglial exosomes. Plos Biology. DOI: 10.1371/Journal.Pbio.1001604.G008  0.732
2013 Frühbeis C, Fröhlich D, Kuo WP, Amphornrat J, Thilemann S, Saab AS, Kirchhoff F, Möbius W, Goebbels S, Nave K, Schneider A, Simons M, Klugmann M, Trotter J, Krämer-Albers E. Somatodendritic and axonal uptake of exosomes. Plos Biology. DOI: 10.1371/Journal.Pbio.1001604.G007  0.734
2012 Sauter D, Unterweger D, Vogl M, Usmani SM, Heigele A, Kluge SF, Hermkes E, Moll M, Barker E, Peeters M, Learn GH, Bibollet-Ruche F, Fritz JV, Fackler OT, Hahn BH, ... Kirchhoff F, et al. Human tetherin exerts strong selection pressure on the HIV-1 group N Vpu protein. Plos Pathogens. 8: e1003093. PMID 23308067 DOI: 10.1371/Journal.Ppat.1003093  0.343
2012 Götz N, Sauter D, Usmani SM, Fritz JV, Goffinet C, Heigele A, Geyer M, Bibollet-Ruche F, Learn GH, Fackler OT, Hahn BH, Kirchhoff F. Reacquisition of Nef-mediated tetherin antagonism in a single in vivo passage of HIV-1 through its original chimpanzee host. Cell Host & Microbe. 12: 373-80. PMID 22980333 DOI: 10.1016/J.Chom.2012.07.008  0.392
2012 Winkler M, Bertram S, Gnirß K, Nehlmeier I, Gawanbacht A, Kirchhoff F, Ehrhardt C, Ludwig S, Kiene M, Moldenhauer AS, Goedecke U, Karsten CB, Kühl A, Pöhlmann S. Influenza A virus does not encode a tetherin antagonist with Vpu-like activity and induces IFN-dependent tetherin expression in infected cells. Plos One. 7: e43337. PMID 22952667 DOI: 10.1371/Journal.Pone.0043337  0.404
2012 Saab AS, Neumeyer A, Jahn HM, Cupido A, Å imek AA, Boele HJ, Scheller A, Le Meur K, Götz M, Monyer H, Sprengel R, Rubio ME, Deitmer JW, De Zeeuw CI, Kirchhoff F. Bergmann glial AMPA receptors are required for fine motor coordination. Science (New York, N.Y.). 337: 749-53. PMID 22767895 DOI: 10.1126/Science.1221140  0.765
2012 Bibollet-Ruche F, Heigele A, Keele BF, Easlick JL, Decker JM, Takehisa J, Learn G, Sharp PM, Hahn BH, Kirchhoff F. Efficient SIVcpz replication in human lymphoid tissue requires viral matrix protein adaptation. The Journal of Clinical Investigation. 122: 1644-52. PMID 22505456 DOI: 10.1172/Jci61429  0.375
2012 Khalid M, Yu H, Sauter D, Usmani SM, Schmokel J, Feldman J, Gruters RA, van der Ende ME, Geyer M, Rowland-Jones S, Osterhaus AD, Kirchhoff F. Efficient Nef-mediated downmodulation of TCR-CD3 and CD28 is associated with high CD4+ T cell counts in viremic HIV-2 infection. Journal of Virology. 86: 4906-20. PMID 22345473 DOI: 10.1128/Jvi.06856-11  0.372
2012 Laguette N, Rahm N, Sobhian B, Chable-Bessia C, Münch J, Snoeck J, Sauter D, Switzer WM, Heneine W, Kirchhoff F, Delsuc F, Telenti A, Benkirane M. Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx protein. Cell Host & Microbe. 11: 205-17. PMID 22305291 DOI: 10.1016/J.Chom.2012.01.007  0.363
2012 Arnold F, Schnell J, Zirafi O, Stürzel C, Meier C, Weil T, Ständker L, Forssmann WG, Roan NR, Greene WC, Kirchhoff F, Münch J. Naturally occurring fragments from two distinct regions of the prostatic acid phosphatase form amyloidogenic enhancers of HIV infection. Journal of Virology. 86: 1244-9. PMID 22090109 DOI: 10.1128/Jvi.06121-11  0.336
2012 Heigele A, Schindler M, Gnanadurai CW, Leonard JA, Collins KL, Kirchhoff F. Down-modulation of CD8αβ is a fundamental activity of primate lentiviral Nef proteins. Journal of Virology. 86: 36-48. PMID 22013062 DOI: 10.1128/Jvi.00717-11  0.367
2012 Kaltenmeier C, Gawanbacht A, Lindner S, Beyer T, Haerter G, Gruener B, Kern P, Kirchhoff F, Schrezenmeier H, Jahrsdörfer B. HIV Triggers Interleukin 21-Mediated Induction of Granzyme B-Secreting B Cells with Regulatory and Antiviral Potential Blood. 120: 1042-1042. DOI: 10.1182/Blood.V120.21.1042.1042  0.375
2011 Roan NR, Müller JA, Liu H, Chu S, Arnold F, Stürzel CM, Walther P, Dong M, Witkowska HE, Kirchhoff F, Münch J, Greene WC. Peptides released by physiological cleavage of semen coagulum proteins form amyloids that enhance HIV infection. Cell Host & Microbe. 10: 541-50. PMID 22177559 DOI: 10.1016/J.Chom.2011.10.010  0.37
2011 Sauter D, Hué S, Petit SJ, Plantier JC, Towers GJ, Kirchhoff F, Gupta RK. HIV-1 Group P is unable to antagonize human tetherin by Vpu, Env or Nef. Retrovirology. 8: 103. PMID 22171785 DOI: 10.1186/1742-4690-8-103  0.347
2011 Sauter D, Kirchhoff F. Tetherin antagonism by primate lentiviral nef proteins. Current Hiv Research. 9: 514-23. PMID 22103835 DOI: 10.2174/157016211798842044  0.4
2011 Sauter D, Vogl M, Kirchhoff F. Ancient origin of a deletion in human BST2/Tetherin that confers protection against viral zoonoses. Human Mutation. 32: 1243-5. PMID 21796732 DOI: 10.1002/Humu.21571  0.369
2011 Lioy DT, Garg SK, Monaghan CE, Raber J, Foust KD, Kaspar BK, Hirrlinger PG, Kirchhoff F, Bissonnette JM, Ballas N, Mandel G. A role for glia in the progression of Rett's syndrome. Nature. 475: 497-500. PMID 21716289 DOI: 10.1038/Nature10214  0.324
2011 Paiardini M, Cervasi B, Reyes-Aviles E, Micci L, Ortiz AM, Chahroudi A, Vinton C, Gordon SN, Bosinger SE, Francella N, Hallberg PL, Cramer E, Schlub T, Chan ML, Riddick NE, ... ... Kirchhoff F, et al. Low levels of SIV infection in sooty mangabey central memory CD⁴⁺ T cells are associated with limited CCR5 expression. Nature Medicine. 17: 830-6. PMID 21706028 DOI: 10.1038/Nm.2395  0.317
2011 Dibaj P, Steffens H, Zschüntzsch J, Kirchhoff F, Schomburg ED, Neusch C. In vivo imaging reveals rapid morphological reactions of astrocytes towards focal lesions in an ALS mouse model. Neuroscience Letters. 497: 148-51. PMID 21539893 DOI: 10.1016/J.Neulet.2011.04.049  0.323
2011 Dibaj P, Steffens H, Zschüntzsch J, Nadrigny F, Schomburg ED, Kirchhoff F, Neusch C. In Vivo imaging reveals distinct inflammatory activity of CNS microglia versus PNS macrophages in a mouse model for ALS. Plos One. 6: e17910. PMID 21437247 DOI: 10.1371/Journal.Pone.0017910  0.341
2011 Tschulena U, Sanzenbacher R, Mühlebach MD, Berger A, Münch J, Schindler M, Kirchhoff F, Plesker R, Coulibaly C, Panitz S, Prüfer S, Muckenfuss H, Hamdorf M, Schweizer M, Cichutek K, et al. Mutation of a diacidic motif in SIV-PBj Nef impairs T-cell activation and enteropathic disease. Retrovirology. 8: 14. PMID 21366921 DOI: 10.1186/1742-4690-8-14  0.347
2011 Schmökel J, Sauter D, Schindler M, Leendertz FH, Bailes E, Dazza MC, Saragosti S, Bibollet-Ruche F, Peeters M, Hahn BH, Kirchhoff F. The presence of a vpu gene and the lack of Nef-mediated downmodulation of T cell receptor-CD3 are not always linked in primate lentiviruses. Journal of Virology. 85: 742-52. PMID 21068258 DOI: 10.1128/Jvi.02087-10  0.342
2011 Dibaj P, Steffens H, Nadrigny F, Kirchhoff F, Schomburg ED. Purinergic activation of dorsal root ganglion neurones in vivo. Neuroscience Letters. 487: 107-9. PMID 20937358 DOI: 10.1016/J.Neulet.2010.10.005  0.309
2011 Kirchhoff F, Münch J. Blocking Semen-mediated enhancement of HIV infection by amyloid-binding small molecules Future Virology. 6: 183-186. DOI: 10.2217/Fvl.10.91  0.373
2011 Meuwissen P, Ariën K, Vandewalle I, Naessens E, Vanderstraeten H, Taghon T, Vanham G, Fackler O, Kirchhoff F, Saksela K, Verhasselt B. Nef interferes with development of thymic T cell precursors: differential mechanisms in HIV and SIV Retrovirology. 8. DOI: 10.1186/1742-4690-8-S2-P48  0.387
2011 Kirchhoff F. Tetherin antagonism by HIV-1 and its SIV precursors Retrovirology. 8. DOI: 10.1186/1742-4690-8-S2-O8  0.377
2011 Kaltenmeier C, Dahlke K, Gawanbacht A, Beyer T, Hofmann S, Härter G, Grüner B, Kern P, Kirchhoff F, Schrezenmeier H, Jahrsdörfer B. HIV-Infected T Cells Induce Granzyme B-Secreting Regulatory B Cells in An Interleukin 21-Dependent Fashion, Blood. 118: 3222-3222. DOI: 10.1182/Blood.V118.21.3222.3222  0.368
2010 Forssmann WG, The YH, Stoll M, Adermann K, Albrecht U, Tillmann HC, Barlos K, Busmann A, Canales-Mayordomo A, Giménez-Gallego G, Hirsch J, Jiménez-Barbero J, Meyer-Olson D, Münch J, Pérez-Castells J, ... ... Kirchhoff F, et al. Short-term monotherapy in HIV-infected patients with a virus entry inhibitor against the gp41 fusion peptide. Science Translational Medicine. 2: 63re3. PMID 21178138 DOI: 10.1126/Scitranslmed.3001697  0.341
2010 Beckervordersandforth R, Tripathi P, Ninkovic J, Bayam E, Lepier A, Stempfhuber B, Kirchhoff F, Hirrlinger J, Haslinger A, Lie DC, Beckers J, Yoder B, Irmler M, Götz M. In vivo fate mapping and expression analysis reveals molecular hallmarks of prospectively isolated adult neural stem cells. Cell Stem Cell. 7: 744-58. PMID 21112568 DOI: 10.1016/J.Stem.2010.11.017  0.318
2010 Gnanadurai CW, Pandrea I, Parrish NF, Kraus MH, Learn GH, Salazar MG, Sauermann U, Töpfer K, Gautam R, Münch J, Stahl-Hennig C, Apetrei C, Hahn BH, Kirchhoff F. Genetic identity and biological phenotype of a transmitted/founder virus representative of nonpathogenic simian immunodeficiency virus infection in African green monkeys. Journal of Virology. 84: 12245-54. PMID 20881048 DOI: 10.1128/Jvi.01603-10  0.32
2010 Kirchhoff F. Immune evasion and counteraction of restriction factors by HIV-1 and other primate lentiviruses. Cell Host & Microbe. 8: 55-67. PMID 20638642 DOI: 10.1016/J.Chom.2010.06.004  0.35
2010 Dibaj P, Steffens H, Nadrigny F, Neusch C, Kirchhoff F, Schomburg ED. Long-lasting post-mortem activity of spinal microglia in situ in mice. Journal of Neuroscience Research. 88: 2431-40. PMID 20623536 DOI: 10.1002/Jnr.22402  0.314
2010 Asztalos BF, Mujawar Z, Morrow MP, Grant A, Pushkarsky T, Wanke C, Shannon R, Geyer M, Kirchhoff F, Sviridov D, Fitzgerald ML, Bukrinsky M, Mansfield KG. Circulating Nef induces dyslipidemia in simian immunodeficiency virus-infected macaques by suppressing cholesterol efflux. The Journal of Infectious Diseases. 202: 614-23. PMID 20617930 DOI: 10.1086/654817  0.328
2010 Kim KA, Yolamanova M, Zirafi O, Roan NR, Staendker L, Forssmann WG, Burgener A, Dejucq-Rainsford N, Hahn BH, Shaw GM, Greene WC, Kirchhoff F, Münch J. Semen-mediated enhancement of HIV infection is donor-dependent and correlates with the levels of SEVI. Retrovirology. 7: 55. PMID 20573198 DOI: 10.1186/1742-4690-7-55  0.379
2010 Specht A, Telenti A, Martinez R, Fellay J, Bailes E, Evans DT, Carrington M, Hahn BH, Goldstein DB, Kirchhoff F. Counteraction of HLA-C-mediated immune control of HIV-1 by Nef. Journal of Virology. 84: 7300-11. PMID 20463068 DOI: 10.1128/Jvi.00619-10  0.343
2010 Sauter D, Specht A, Kirchhoff F. Tetherin: holding on and letting go. Cell. 141: 392-8. PMID 20434978 DOI: 10.1016/J.Cell.2010.04.022  0.335
2010 Banning C, Votteler J, Hoffmann D, Koppensteiner H, Warmer M, Reimer R, Kirchhoff F, Schubert U, Hauber J, Schindler M. A flow cytometry-based FRET assay to identify and analyse protein-protein interactions in living cells. Plos One. 5: e9344. PMID 20179761 DOI: 10.1371/Journal.Pone.0009344  0.367
2010 Reichenbach A, Derouiche A, Kirchhoff F. Morphology and dynamics of perisynaptic glia. Brain Research Reviews. 63: 11-25. PMID 20176054 DOI: 10.1016/J.Brainresrev.2010.02.003  0.321
2010 Schindler M, Rajan D, Banning C, Wimmer P, Koppensteiner H, Iwanski A, Specht A, Sauter D, Dobner T, Kirchhoff F. Vpu serine 52 dependent counteraction of tetherin is required for HIV-1 replication in macrophages, but not in ex vivo human lymphoid tissue. Retrovirology. 7: 1. PMID 20078884 DOI: 10.1186/1742-4690-7-1  0.392
2010 Arhel N, Kirchhoff F. Host proteins involved in HIV infection: new therapeutic targets. Biochimica Et Biophysica Acta. 1802: 313-21. PMID 20018238 DOI: 10.1016/J.Bbadis.2009.12.003  0.376
2010 Roan NR, Sowinski S, Münch J, Kirchhoff F, Greene WC. Aminoquinoline surfen inhibits the action of SEVI (semen-derived enhancer of viral infection). The Journal of Biological Chemistry. 285: 1861-9. PMID 19897482 DOI: 10.1074/Jbc.M109.066167  0.382
2010 Dibaj P, Steffens H, Zschüntzsch J, Schomburg E, Kirchhoff F, Neusch C. Microglial contribution to neurodegeneration within the CNS and inflammation-independent degeneration within the PNS in the SOD1 (G93A) mouse model for ALS – a 2P-LSM study in vivo Klinische Neurophysiologie. 41. DOI: 10.1055/S-0030-1250927  0.338
2009 Arhel NJ, Kirchhoff F. Implications of Nef: host cell interactions in viral persistence and progression to AIDS. Current Topics in Microbiology and Immunology. 339: 147-75. PMID 20012528 DOI: 10.1007/978-3-642-02175-6_8  0.391
2009 Sauter D, Schindler M, Specht A, Landford WN, Münch J, Kim KA, Votteler J, Schubert U, Bibollet-Ruche F, Keele BF, Takehisa J, Ogando Y, Ochsenbauer C, Kappes JC, Ayouba A, ... ... Kirchhoff F, et al. Tetherin-driven adaptation of Vpu and Nef function and the evolution of pandemic and nonpandemic HIV-1 strains. Cell Host & Microbe. 6: 409-21. PMID 19917496 DOI: 10.1016/J.Chom.2009.10.004  0.367
2009 Arhel N, Lehmann M, Clauss K, Nienhaus GU, Piguet V, Kirchhoff F. The inability to disrupt the immunological synapse between infected human T cells and APCs distinguishes HIV-1 from most other primate lentiviruses. The Journal of Clinical Investigation. 119: 2965-75. PMID 19759518 DOI: 10.1172/Jci38994  0.41
2009 Sodora DL, Allan JS, Apetrei C, Brenchley JM, Douek DC, Else JG, Estes JD, Hahn BH, Hirsch VM, Kaur A, Kirchhoff F, Muller-Trutwin M, Pandrea I, Schmitz JE, Silvestri G. Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts. Nature Medicine. 15: 861-5. PMID 19661993 DOI: 10.1038/Nm.2013  0.322
2009 Zhang F, Wilson SJ, Landford WC, Virgen B, Gregory D, Johnson MC, Munch J, Kirchhoff F, Bieniasz PD, Hatziioannou T. Nef proteins from simian immunodeficiency viruses are tetherin antagonists. Cell Host & Microbe. 6: 54-67. PMID 19501037 DOI: 10.1016/J.Chom.2009.05.008  0.366
2009 Strauss G, Lindquist JA, Arhel N, Felder E, Karl S, Haas TL, Fulda S, Walczak H, Kirchhoff F, Debatin KM. CD95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signaling. The Journal of Experimental Medicine. 206: 1379-93. PMID 19487421 DOI: 10.1084/Jem.20082363  0.322
2009 Ylera B, Ertürk A, Hellal F, Nadrigny F, Hurtado A, Tahirovic S, Oudega M, Kirchhoff F, Bradke F. Chronically CNS-injured adult sensory neurons gain regenerative competence upon a lesion of their peripheral axon. Current Biology : Cb. 19: 930-6. PMID 19409789 DOI: 10.1016/J.Cub.2009.04.017  0.302
2009 Schmökel J, Li H, Bailes E, Schindler M, Silvestri G, Hahn BH, Apetrei C, Kirchhoff F. Conservation of Nef function across highly diverse lineages of SIVsmm. Retrovirology. 6: 36. PMID 19358735 DOI: 10.1186/1742-4690-6-36  0.359
2009 Kirchhoff F. Is the high virulence of HIV-1 an unfortunate coincidence of primate lentiviral evolution? Nature Reviews. Microbiology. 7: 467-76. PMID 19305418 DOI: 10.1038/Nrmicro2111  0.382
2009 Hirrlinger J, Scheller A, Hirrlinger PG, Kellert B, Tang W, Wehr MC, Goebbels S, Reichenbach A, Sprengel R, Rossner MJ, Kirchhoff F. Split-cre complementation indicates coincident activity of different genes in vivo. Plos One. 4: e4286. PMID 19172189 DOI: 10.1371/Journal.Pone.0004286  0.574
2009 Roan NR, Münch J, Arhel N, Mothes W, Neidleman J, Kobayashi A, Smith-McCune K, Kirchhoff F, Greene WC. The cationic properties of SEVI underlie its ability to enhance human immunodeficiency virus infection. Journal of Virology. 83: 73-80. PMID 18945786 DOI: 10.1128/Jvi.01366-08  0.381
2009 Kyeong-Ae K, Jiang S, Kirchhoff F, Muench J. SEVI and Semen Impair the Anti-HIV-1 Activity of Drugs and Microbicides Antiviral Research. 82. DOI: 10.1016/J.Antiviral.2009.02.155  0.306
2008 Dimou L, Simon C, Kirchhoff F, Takebayashi H, Götz M. Progeny of Olig2-expressing progenitors in the gray and white matter of the adult mouse cerebral cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 10434-42. PMID 18842903 DOI: 10.1523/Jneurosci.2831-08.2008  0.31
2008 Kirchhoff F. Silencing HIV-1 In Vivo. Cell. 134: 566-8. PMID 18724929 DOI: 10.1016/J.Cell.2008.08.004  0.347
2008 Schindler M, Schmökel J, Specht A, Li H, Münch J, Khalid M, Sodora DL, Hahn BH, Silvestri G, Kirchhoff F. Inefficient Nef-mediated downmodulation of CD3 and MHC-I correlates with loss of CD4+T cells in natural SIV infection. Plos Pathogens. 4: e1000107. PMID 18636106 DOI: 10.1371/Journal.Ppat.1000107  0.314
2008 Toussaint H, Gobert FX, Schindler M, Banning C, Kozik P, Jouve M, Kirchhoff F, Benaroch P. Human immunodeficiency virus type 1 nef expression prevents AP-2-mediated internalization of the major histocompatibility complex class II-associated invariant chain. Journal of Virology. 82: 8373-82. PMID 18596106 DOI: 10.1128/Jvi.00670-08  0.322
2008 Haupt S, Donhauser N, Chaipan C, Schuster P, Puffer B, Daniels RS, Greenough TC, Kirchhoff F, Schmidt B. CD4 binding affinity determines human immunodeficiency virus type 1-induced alpha interferon production in plasmacytoid dendritic cells. Journal of Virology. 82: 8900-5. PMID 18579609 DOI: 10.1128/Jvi.00196-08  0.347
2008 Lalo U, Pankratov Y, Wichert SP, Rossner MJ, North RA, Kirchhoff F, Verkhratsky A. P2X1 and P2X5 subunits form the functional P2X receptor in mouse cortical astrocytes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 5473-80. PMID 18495881 DOI: 10.1523/Jneurosci.1149-08.2008  0.566
2008 Kirchhoff F, Schindler M, Specht A, Arhel N, Münch J. Role of Nef in primate lentiviral immunopathogenesis. Cellular and Molecular Life Sciences : Cmls. 65: 2621-36. PMID 18438604 DOI: 10.1007/S00018-008-8094-2  0.404
2008 Kirchhoff F, Silvestri G. Is Nef the elusive cause of HIV-associated hematopoietic dysfunction? The Journal of Clinical Investigation. 118: 1622-5. PMID 18431512 DOI: 10.1172/Jci35487  0.399
2008 Hamilton N, Vayro S, Kirchhoff F, Verkhratsky A, Robbins J, Gorecki DC, Butt AM. Mechanisms of ATP- and glutamate-mediated calcium signaling in white matter astrocytes. Glia. 56: 734-49. PMID 18293404 DOI: 10.1002/Glia.20649  0.311
2008 DeGottardi MQ, Specht A, Metcalf B, Kaur A, Kirchhoff F, Evans DT. Selective downregulation of rhesus macaque and sooty mangabey major histocompatibility complex class I molecules by Nef alleles of simian immunodeficiency virus and human immunodeficiency virus type 2. Journal of Virology. 82: 3139-46. PMID 18199657 DOI: 10.1128/Jvi.02102-07  0.355
2008 Specht A, DeGottardi MQ, Schindler M, Hahn B, Evans DT, Kirchhoff F. Selective downmodulation of HLA-A and -B by Nef alleles from different groups of primate lentiviruses. Virology. 373: 229-37. PMID 18155264 DOI: 10.1016/J.Virol.2007.11.019  0.347
2007 Münch J, Rücker E, Ständker L, Adermann K, Goffinet C, Schindler M, Wildum S, Chinnadurai R, Rajan D, Specht A, Giménez-Gallego G, Sánchez PC, Fowler DM, Koulov A, Kelly JW, ... ... Kirchhoff F, et al. Semen-derived amyloid fibrils drastically enhance HIV infection. Cell. 131: 1059-71. PMID 18083097 DOI: 10.1016/J.Cell.2007.10.014  0.393
2007 Münch J, Rajan D, Schindler M, Specht A, Rücker E, Novembre FJ, Nerrienet E, Müller-Trutwin MC, Peeters M, Hahn BH, Kirchhoff F. Nef-mediated enhancement of virion infectivity and stimulation of viral replication are fundamental properties of primate lentiviruses. Journal of Virology. 81: 13852-64. PMID 17928336 DOI: 10.1128/Jvi.00904-07  0.405
2007 Potthoff AV, Münch J, Kirchhoff F, Brockmeyer NH. HIV infection in a patient with alpha-1 antitrypsin deficiency: a detrimental combination? Aids (London, England). 21: 2115-6. PMID 17885308 DOI: 10.1097/Qad.0B013E3282F08B97  0.315
2007 Schindler M, Rajan D, Specht A, Ritter C, Pulkkinen K, Saksela K, Kirchhoff F. Association of Nef with p21-activated kinase 2 is dispensable for efficient human immunodeficiency virus type 1 replication and cytopathicity in ex vivo-infected human lymphoid tissue. Journal of Virology. 81: 13005-14. PMID 17881449 DOI: 10.1128/Jvi.01436-07  0.409
2007 He Y, Liu S, Jing W, Lu H, Cai D, Chin DJ, Debnath AK, Kirchhoff F, Jiang S. Conserved residue Lys574 in the cavity of HIV-1 Gp41 coiled-coil domain is critical for six-helix bundle stability and virus entry. The Journal of Biological Chemistry. 282: 25631-9. PMID 17616522 DOI: 10.1074/Jbc.M703781200  0.36
2007 Votteler J, Studtrucker N, Sörgel S, Münch J, Rücker E, Kirchhoff F, Schick B, Henklein P, Fossen T, Bruns K, Sharma A, Wray V, Schubert U. Proline 35 of human immunodeficiency virus type 1 (HIV-1) Vpr regulates the integrity of the N-terminal helix and the incorporation of Vpr into virus particles and supports the replication of R5-tropic HIV-1 in human lymphoid tissue ex vivo. Journal of Virology. 81: 9572-6. PMID 17553868 DOI: 10.1128/Jvi.02803-06  0.365
2007 Verkhratsky A, Kirchhoff F. Glutamate-mediated neuronal-glial transmission. Journal of Anatomy. 210: 651-60. PMID 17504269 DOI: 10.1111/J.1469-7580.2007.00734.X  0.331
2007 Schindler M, Wildum S, Casartelli N, Doria M, Kirchhoff F. Nef alleles from children with non-progressive HIV-1 infection modulate MHC-II expression more efficiently than those from rapid progressors. Aids (London, England). 21: 1103-7. PMID 17502720 DOI: 10.1097/Qad.0B013E32816Aa37C  0.379
2007 Wigley R, Hamilton N, Nishiyama A, Kirchhoff F, Butt AM. Morphological and physiological interactions of NG2-glia with astrocytes and neurons. Journal of Anatomy. 210: 661-70. PMID 17459143 DOI: 10.1111/J.1469-7580.2007.00729.X  0.341
2007 Münch J, Ständker L, Adermann K, Schulz A, Schindler M, Chinnadurai R, Pöhlmann S, Chaipan C, Biet T, Peters T, Meyer B, Wilhelm D, Lu H, Jing W, Jiang S, ... ... Kirchhoff F, et al. Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide. Cell. 129: 263-75. PMID 17448989 DOI: 10.1016/J.Cell.2007.02.042  0.335
2007 Giaume C, Kirchhoff F, Matute C, Reichenbach A, Verkhratsky A. Glia: the fulcrum of brain diseases. Cell Death and Differentiation. 14: 1324-35. PMID 17431421 DOI: 10.1038/Sj.Cdd.4402144  0.319
2007 Chinnadurai R, Rajan D, Münch J, Kirchhoff F. Human immunodeficiency virus type 1 variants resistant to first- and second-version fusion inhibitors and cytopathic in ex vivo human lymphoid tissue. Journal of Virology. 81: 6563-72. PMID 17428857 DOI: 10.1128/Jvi.02546-06  0.341
2007 Priceputu E, Hanna Z, Hu C, Simard MC, Vincent P, Wildum S, Schindler M, Kirchhoff F, Jolicoeur P. Primary human immunodeficiency virus type 1 nef alleles show major differences in pathogenicity in transgenic mice. Journal of Virology. 81: 4677-93. PMID 17314161 DOI: 10.1128/Jvi.02691-06  0.334
2007 Verkhratsky A, Kirchhoff F. NMDA Receptors in glia. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 13: 28-37. PMID 17229973 DOI: 10.1177/1073858406294270  0.322
2007 Pöhlmann S, Münch J, Aziz S, Reeves JD, Otto C, Leslie GJ, Hofmann H, Puffer BA, Baribaud F, Marzi A, Gramberg T, Chen Z, Stolte N, Haaft PT, Heeney JL, ... ... Kirchhoff F, et al. A simian immunodeficiency virus V3 loop mutant that does not efficiently use CCR5 or common alternative coreceptors is moderately attenuated in vivo. Virology. 360: 275-85. PMID 17126374 DOI: 10.1016/J.Virol.2006.10.020  0.365
2007 Chvátal A, Anderová M, Hock M, Prajerová I, Neprasová H, Chvátal V, Kirchhoff F, Syková E. Three-dimensional confocal morphometry reveals structural changes in astrocyte morphology in situ. Journal of Neuroscience Research. 85: 260-71. PMID 17086549 DOI: 10.1002/Jnr.21113  0.325
2007 Gupta S, Fuchs B, Schulz-Maronde S, Heitland A, Escher S, Münch J, Kirchhoff F, Mack M, Tillmann H, Braun A, Forssmann W, Forssmann U, Elsner J. Inhibition Of Airway Inflammation And HIV Entry By NNY-CCL14 Treatment: Role Of CCR1 And CCR5 Journal of Allergy and Clinical Immunology. 119: S139. DOI: 10.1016/J.Jaci.2006.11.671  0.328
2006 Lu YB, Franze K, Seifert G, Steinhäuser C, Kirchhoff F, Wolburg H, Guck J, Janmey P, Wei EQ, Käs J, Reichenbach A. Viscoelastic properties of individual glial cells and neurons in the CNS. Proceedings of the National Academy of Sciences of the United States of America. 103: 17759-64. PMID 17093050 DOI: 10.1073/Pnas.0606150103  0.317
2006 Wildum S, Schindler M, Münch J, Kirchhoff F. Contribution of Vpu, Env, and Nef to CD4 down-modulation and resistance of human immunodeficiency virus type 1-infected T cells to superinfection. Journal of Virology. 80: 8047-59. PMID 16873261 DOI: 10.1128/Jvi.00252-06  0.401
2006 Schindler M, Münch J, Kutsch O, Li H, Santiago ML, Bibollet-Ruche F, Müller-Trutwin MC, Novembre FJ, Peeters M, Courgnaud V, Bailes E, Roques P, Sodora DL, Silvestri G, Sharp PM, ... ... Kirchhoff F, et al. Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1. Cell. 125: 1055-67. PMID 16777597 DOI: 10.1016/J.Cell.2006.04.033  0.401
2006 Brenner M, Münch J, Schindler M, Wildum S, Stolte N, Stahl-Hennig C, Fuchs D, Mätz-Rensing K, Franz M, Heeney J, Ten Haaft P, Swigut T, Hrecka K, Skowronski J, Kirchhoff F. Importance of the N-distal AP-2 binding element in Nef for simian immunodeficiency virus replication and pathogenicity in rhesus macaques. Journal of Virology. 80: 4469-81. PMID 16611907 DOI: 10.1128/Jvi.80.9.4469-4481.2006  0.338
2006 Hirrlinger PG, Scheller A, Braun C, Hirrlinger J, Kirchhoff F. Temporal control of gene recombination in astrocytes by transgenic expression of the tamoxifen-inducible DNA recombinase variant CreERT2. Glia. 54: 11-20. PMID 16575885 DOI: 10.1002/Glia.20342  0.331
2006 Rajan D, Wildum S, Rücker E, Schindler M, Kirchhoff F. Effect of R77Q, R77A and R80A changes in Vpr on HIV-1 replication and CD4 T cell depletion in human lymphoid tissue ex vivo. Aids (London, England). 20: 831-6. PMID 16549966 DOI: 10.1097/01.Aids.0000218546.31716.7F  0.372
2006 Lalo U, Pankratov Y, Kirchhoff F, North RA, Verkhratsky A. NMDA receptors mediate neuron-to-glia signaling in mouse cortical astrocytes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 2673-83. PMID 16525046 DOI: 10.1523/Jneurosci.4689-05.2006  0.313
2006 Fauré J, Lachenal G, Court M, Hirrlinger J, Chatellard-Causse C, Blot B, Grange J, Schoehn G, Goldberg Y, Boyer V, Kirchhoff F, Raposo G, Garin J, Sadoul R. Exosomes are released by cultured cortical neurones. Molecular and Cellular Neurosciences. 31: 642-8. PMID 16446100 DOI: 10.1016/J.Mcn.2005.12.003  0.308
2006 Schindler M, Münch J, Kutsch O, Li H, Santiago ML, Bibollet-Ruche F, Müller-Trutwin MC, Novembre FJ, Peeters M, Courgnaud V, Bailes E, Roques P, Sodora DL, Sharp P, Silvestri G, ... ... Kirchhoff F, et al. Retrovirology. 3: S95. DOI: 10.1186/1742-4690-3-S1-S95  0.365
2005 Hirrlinger J, Moeller H, Kirchhoff F, Dringen R. Expression of multidrug resistance proteins (Mrps) in astrocytes of the mouse brain: a single cell RT-PCR study. Neurochemical Research. 30: 1237-44. PMID 16341585 DOI: 10.1007/S11064-005-8795-Y  0.324
2005 Chinnadurai R, Münch J, Dittmar MT, Kirchhoff F. Inhibition of HIV-1 group M and O isolates by fusion inhibitors. Aids (London, England). 19: 1919-22. PMID 16227804 DOI: 10.1097/01.Aids.0000188425.79914.E4  0.317
2005 Hirrlinger PG, Scheller A, Braun C, Quintela-Schneider M, Fuss B, Hirrlinger J, Kirchhoff F. Expression of reef coral fluorescent proteins in the central nervous system of transgenic mice. Molecular and Cellular Neurosciences. 30: 291-303. PMID 16169246 DOI: 10.1016/J.Mcn.2005.08.011  0.329
2005 Chinnadurai R, Münch J, Kirchhoff F. Effect of naturally-occurring gp41 HR1 variations on susceptibility of HIV-1 to fusion inhibitors. Aids (London, England). 19: 1401-5. PMID 16103771 DOI: 10.1097/01.Aids.0000180785.25800.De  0.348
2005 Münch J, Rajan D, Rücker E, Wildum S, Adam N, Kirchhoff F. The role of upstream U3 sequences in HIV-1 replication and CD4+ T cell depletion in human lymphoid tissue ex vivo. Virology. 341: 313-20. PMID 16102792 DOI: 10.1016/J.Virol.2005.07.023  0.373
2005 Hrecka K, Swigut T, Schindler M, Kirchhoff F, Skowronski J. Nef proteins from diverse groups of primate lentiviruses downmodulate CXCR4 to inhibit migration to the chemokine stromal derived factor 1. Journal of Virology. 79: 10650-9. PMID 16051857 DOI: 10.1128/Jvi.79.16.10650-10659.2005  0.422
2005 Münch J, Schindler M, Wildum S, Rücker E, Bailer N, Knoop V, Novembre FJ, Kirchhoff F. Primary sooty mangabey simian immunodeficiency virus and human immunodeficiency virus type 2 nef alleles modulate cell surface expression of various human receptors and enhance viral infectivity and replication. Journal of Virology. 79: 10547-60. PMID 16051847 DOI: 10.1128/Jvi.79.16.10547-10560.2005  0.409
2005 van 't Wout AB, Swain JV, Schindler M, Rao U, Pathmajeyan MS, Mullins JI, Kirchhoff F. Nef induces multiple genes involved in cholesterol synthesis and uptake in human immunodeficiency virus type 1-infected T cells. Journal of Virology. 79: 10053-8. PMID 16014965 DOI: 10.1128/Jvi.79.15.10053-10058.2005  0.39
2005 Nimmerjahn A, Kirchhoff F, Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science (New York, N.Y.). 308: 1314-8. PMID 15831717 DOI: 10.1515/Nf-2005-0304  0.666
2005 Schindler M, Münch J, Kirchhoff F. Human immunodeficiency virus type 1 inhibits DNA damage-triggered apoptosis by a Nef-independent mechanism. Journal of Virology. 79: 5489-98. PMID 15827163 DOI: 10.1128/Jvi.79.9.5489-5498.2005  0.391
2004 Nimmerjahn A, Kirchhoff F, Kerr JN, Helmchen F. Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo. Nature Methods. 1: 31-7. PMID 15782150 DOI: 10.1038/Nmeth706  0.685
2004 Rücker E, Grivel JC, Münch J, Kirchhoff F, Margolis L. Vpr and Vpu are important for efficient human immunodeficiency virus type 1 replication and CD4+ T-cell depletion in human lymphoid tissue ex vivo. Journal of Virology. 78: 12689-93. PMID 15507658 DOI: 10.1128/Jvi.78.22.12689-12693.2004  0.39
2004 Schindler M, Münch J, Brenner M, Stahl-Hennig C, Skowronski J, Kirchhoff F. Comprehensive analysis of nef functions selected in simian immunodeficiency virus-infected macaques. Journal of Virology. 78: 10588-97. PMID 15367626 DOI: 10.1128/Jvi.78.19.10588-10597.2004  0.337
2004 Rücker E, Münch J, Wildum S, Brenner M, Eisemann J, Margolis L, Kirchhoff F. A naturally occurring variation in the proline-rich region does not attenuate human immunodeficiency virus type 1 nef function. Journal of Virology. 78: 10197-201. PMID 15331753 DOI: 10.1128/Jvi.78.18.10197-10201.2004  0.368
2004 Hiebenthal-Millow K, Pöhlmann S, Münch J, Kirchhoff F. Differential regulation of human immunodeficiency virus type 2 and simian immunodeficiency virus promoter activity. Virology. 324: 501-9. PMID 15207635 DOI: 10.1016/J.Virol.2004.04.007  0.383
2004 Kirchhoff F, Schindler M, Bailer N, Renkema GH, Saksela K, Knoop V, Müller-Trutwin MC, Santiago ML, Bibollet-Ruche F, Dittmar MT, Heeney JL, Hahn BH, Münch J. Nef proteins from simian immunodeficiency virus-infected chimpanzees interact with p21-activated kinase 2 and modulate cell surface expression of various human receptors. Journal of Virology. 78: 6864-74. PMID 15194762 DOI: 10.1128/Jvi.78.13.6864-6874.2004  0.4
2004 Pöhlmann S, Davis C, Meister S, Leslie GJ, Otto C, Reeves JD, Puffer BA, Papkalla A, Krumbiegel M, Marzi A, Lorenz S, Münch J, Doms RW, Kirchhoff F. Amino acid 324 in the simian immunodeficiency virus SIVmac V3 loop can confer CD4 independence and modulate the interaction with CCR5 and alternative coreceptors. Journal of Virology. 78: 3223-32. PMID 15016843 DOI: 10.1128/Jvi.78.7.3223-3232.2004  0.343
2004 Grass D, Pawlowski PG, Hirrlinger J, Papadopoulos N, Richter DW, Kirchhoff F, Hülsmann S. Diversity of functional astroglial properties in the respiratory network. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 1358-65. PMID 14960607 DOI: 10.1523/Jneurosci.4022-03.2004  0.313
2003 Hiebenthal-Millow K, Greenough TC, Bretttler DB, Schindler M, Wildum S, Sullivan JL, Kirchhoff F. Alterations in HIV-1 LTR promoter activity during AIDS progression. Virology. 317: 109-18. PMID 14675629 DOI: 10.1016/J.Virol.2003.08.034  0.378
2003 Hüttmann K, Sadgrove M, Wallraff A, Hinterkeuser S, Kirchhoff F, Steinhäuser C, Gray WP. Seizures preferentially stimulate proliferation of radial glia-like astrocytes in the adult dentate gyrus: functional and immunocytochemical analysis. The European Journal of Neuroscience. 18: 2769-78. PMID 14656326 DOI: 10.1111/J.1460-9568.2003.03002.X  0.311
2003 Otto C, Puffer BA, Pöhlmann S, Doms RW, Kirchhoff F. Mutations in the C3 region of human and simian immunodeficiency virus envelope have differential effects on viral infectivity, replication, and CD4-dependency. Virology. 315: 292-302. PMID 14585332 DOI: 10.1016/S0042-6822(03)00513-0  0.353
2003 Schindler M, Würfl S, Benaroch P, Greenough TC, Daniels R, Easterbrook P, Brenner M, Münch J, Kirchhoff F. Down-modulation of mature major histocompatibility complex class II and up-regulation of invariant chain cell surface expression are well-conserved functions of human and simian immunodeficiency virus nef alleles. Journal of Virology. 77: 10548-56. PMID 12970439 DOI: 10.1128/Jvi.77.19.10548-10556.2003  0.354
2003 Wehner T, Böntert M, Eyüpoglu I, Prass K, Prinz M, Klett FF, Heinze M, Bechmann I, Nitsch R, Kirchhoff F, Kettenmann H, Dirnagl U, Priller J. Bone marrow-derived cells expressing green fluorescent protein under the control of the glial fibrillary acidic protein promoter do not differentiate into astrocytes in vitro and in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 5004-11. PMID 12832523 DOI: 10.1523/Jneurosci.23-12-05004.2003  0.334
2003 Argañaraz ER, Schindler M, Kirchhoff F, Cortes MJ, Lama J. Enhanced CD4 down-modulation by late stage HIV-1 nef alleles is associated with increased Env incorporation and viral replication. The Journal of Biological Chemistry. 278: 33912-9. PMID 12816953 DOI: 10.1074/Jbc.M303679200  0.374
2003 Matthias K, Kirchhoff F, Seifert G, Hüttmann K, Matyash M, Kettenmann H, Steinhäuser C. Segregated expression of AMPA-type glutamate receptors and glutamate transporters defines distinct astrocyte populations in the mouse hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 1750-8. PMID 12629179 DOI: 10.1523/Jneurosci.23-05-01750.2003  0.356
2003 Malatesta P, Hack MA, Hartfuss E, Kettenmann H, Klinkert W, Kirchhoff F, Götz M. Neuronal or glial progeny: regional differences in radial glia fate. Neuron. 37: 751-64. PMID 12628166 DOI: 10.1016/S0896-6273(03)00116-8  0.311
2003 Casarosa P, Menge WM, Minisini R, Otto C, van Heteren J, Jongejan A, Timmerman H, Moepps B, Kirchhoff F, Mertens T, Smit MJ, Leurs R. Identification of the first nonpeptidergic inverse agonist for a constitutively active viral-encoded G protein-coupled receptor. The Journal of Biological Chemistry. 278: 5172-8. PMID 12456673 DOI: 10.1074/Jbc.M210033200  0.354
2002 Münch J, Janardhan A, Stolte N, Stahl-Hennig C, Ten Haaft P, Heeney JL, Swigut T, Kirchhoff F, Skowronski J. T-cell receptor:CD3 down-regulation is a selected in vivo function of simian immunodeficiency virus Nef but is not sufficient for effective viral replication in rhesus macaques. Journal of Virology. 76: 12360-4. PMID 12414978 DOI: 10.1128/Jvi.76.23.12360-12364.2002  0.363
2002 Papkalla A, Münch J, Otto C, Kirchhoff F. Nef enhances human immunodeficiency virus type 1 infectivity and replication independently of viral coreceptor tropism. Journal of Virology. 76: 8455-9. PMID 12134048 DOI: 10.1128/Jvi.76.16.8455-8459.2002  0.373
2002 Münch J, Ständker L, Pöhlmann S, Baribaud F, Papkalla A, Rosorius O, Stauber R, Sass G, Heveker N, Adermann K, Escher S, Klüver E, Doms RW, Forssmann WG, Kirchhoff F. Hemofiltrate CC chemokine 1[9-74] causes effective internalization of CCR5 and is a potent inhibitor of R5-tropic human immunodeficiency virus type 1 strains in primary T cells and macrophages. Antimicrobial Agents and Chemotherapy. 46: 982-90. PMID 11897579 DOI: 10.1128/Aac.46.4.982-990.2002  0.348
2002 Hiebenthal-Millow K, Kirchhoff F. The most frequent naturally occurring length polymorphism in the HIV-1 LTR has little effect on proviral transcription and viral replication. Virology. 292: 169-75. PMID 11878920 DOI: 10.1006/Viro.2001.1282  0.399
2001 Synowitz M, Ahmann P, Matyash M, Kuhn SA, Hofmann B, Zimmer C, Kirchhoff F, Kiwit JC, Kettenmann H. GABA(A)-receptor expression in glioma cells is triggered by contact with neuronal cells. The European Journal of Neuroscience. 14: 1294-302. PMID 11703458 DOI: 10.1046/J.0953-816X.2001.01764.X  0.302
2001 Kirchhoff F, Dringen R, Giaume C. Pathways of neuron-astrocyte interactions and their possible role in neuroprotection. European Archives of Psychiatry and Clinical Neuroscience. 251: 159-69. PMID 11697580 DOI: 10.1007/S004060170036  0.328
2001 Münch J, Stolte N, Fuchs D, Stahl-Hennig C, Kirchhoff F. Efficient class I major histocompatibility complex down-regulation by simian immunodeficiency virus Nef is associated with a strong selective advantage in infected rhesus macaques. Journal of Virology. 75: 10532-6. PMID 11581427 DOI: 10.1128/Jvi.75.21.10532-10536.2001  0.345
2001 Pöhlmann S, Leslie GJ, Edwards TG, Macfarlan T, Reeves JD, Hiebenthal-Millow K, Kirchhoff F, Baribaud F, Doms RW. DC-SIGN interactions with human immunodeficiency virus: virus binding and transfer are dissociable functions. Journal of Virology. 75: 10523-6. PMID 11581425 DOI: 10.1128/Jvi.75.21.10523-10526.2001  0.346
2001 Glushakova S, Münch J, Carl S, Greenough TC, Sullivan JL, Margolis L, Kirchhoff F. CD4 down-modulation by human immunodeficiency virus type 1 Nef correlates with the efficiency of viral replication and with CD4(+) T-cell depletion in human lymphoid tissue ex vivo. Journal of Virology. 75: 10113-7. PMID 11581379 DOI: 10.1128/Jvi.75.21.10113-10117.2001  0.39
2001 Münch J, Adam N, Finze N, Stolte N, Stahl-Hennig C, Fuchs D, Ten Haaft P, Heeney JL, Kirchhoff F. Simian immunodeficiency virus in which nef and U3 sequences do not overlap replicates efficiently in vitro and in vivo in rhesus macaques. Journal of Virology. 75: 8137-46. PMID 11483759 DOI: 10.1128/Jvi.75.17.8137-8146.2001  0.348
2001 Meister S, Otto C, Papkalla A, Krumbiegel M, Pöhlmann S, Kirchhoff F. Basic amino acid residues in the V3 loop of simian immunodeficiency virus envelope alter viral coreceptor tropism and infectivity but do not allow efficient utilization of CXCR4 as entry cofactor. Virology. 284: 287-96. PMID 11384227 DOI: 10.1006/Viro.2001.0852  0.362
2001 Schipke CG, Ohlemeyer C, Matyash M, Nolte C, Kettenmann H, Kirchhoff F. Astrocytes of the mouse neocortex express functional N-methyl-D-aspartate receptors. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 15: 1270-2. PMID 11344110 DOI: 10.1096/Fj.00-0439Fje  0.337
2001 Diers-Fenger M, Kirchhoff F, Kettenmann H, Levine JM, Trotter J. AN2/NG2 protein-expressing glial progenitor cells in the murine CNS: isolation, differentiation, and association with radial glia. Glia. 34: 213-28. PMID 11329183 DOI: 10.1002/Glia.1055  0.333
2001 Pöhlmann S, Baribaud F, Lee B, Leslie GJ, Sanchez MD, Hiebenthal-Millow K, Münch J, Kirchhoff F, Doms RW. DC-SIGN interactions with human immunodeficiency virus type 1 and 2 and simian immunodeficiency virus. Journal of Virology. 75: 4664-72. PMID 11312337 DOI: 10.1128/Jvi.75.10.4664-4672.2001  0.373
2001 Carl S, Greenough TC, Krumbiegel M, Greenberg M, Skowronski J, Sullivan JL, Kirchhoff F. Modulation of different human immunodeficiency virus type 1 Nef functions during progression to AIDS. Journal of Virology. 75: 3657-65. PMID 11264355 DOI: 10.1128/Jvi.75.8.3657-3665.2001  0.406
2001 Nolte C, Matyash M, Pivneva T, Schipke CG, Ohlemeyer C, Hanisch UK, Kirchhoff F, Kettenmann H. GFAP promoter-controlled EGFP-expressing transgenic mice: a tool to visualize astrocytes and astrogliosis in living brain tissue. Glia. 33: 72-86. PMID 11169793 DOI: 10.1002/1098-1136(20010101)33:1<72::Aid-Glia1007>3.0.Co;2-A  0.341
2000 Detheux M, Ständker L, Vakili J, Münch J, Forssmann U, Adermann K, Pöhlmann S, Vassart G, Kirchhoff F, Parmentier M, Forssmann WG. Natural proteolytic processing of hemofiltrate CC chemokine 1 generates a potent CC chemokine receptor (CCR)1 and CCR5 agonist with anti-HIV properties. The Journal of Experimental Medicine. 192: 1501-8. PMID 11085751 DOI: 10.1084/Jem.192.10.1501  0.341
2000 Iafrate AJ, Carl S, Bronson S, Stahl-Hennig C, Swigut T, Skowronski J, Kirchhoff F. Disrupting surfaces of nef required for downregulation of CD4 and for enhancement of virion infectivity attenuates simian immunodeficiency virus replication in vivo. Journal of Virology. 74: 9836-44. PMID 11024110 DOI: 10.1128/Jvi.74.21.9836-9844.2000  0.372
2000 Schramm B, Penn ML, Palacios EH, Grant RM, Kirchhoff F, Goldsmith MA. Cytopathicity of human immunodeficiency virus type 2 (HIV-2) in human lymphoid tissue is coreceptor dependent and comparable to that of HIV-1. Journal of Virology. 74: 9594-600. PMID 11000231 DOI: 10.1128/Jvi.74.20.9594-9600.2000  0.369
2000 Sharron M, Pöhlmann S, Price K, Lolis E, Tsang M, Kirchhoff F, Doms RW, Lee B. Expression and coreceptor activity of STRL33/Bonzo on primary peripheral blood lymphocytes. Blood. 96: 41-9. PMID 10891428 DOI: 10.1182/Blood.V96.1.41.013K53_41_49  0.382
2000 Swigut T, Iafrate AJ, Muench J, Kirchhoff F, Skowronski J. Simian and human immunodeficiency virus Nef proteins use different surfaces to downregulate class I major histocompatibility complex antigen expression. Journal of Virology. 74: 5691-701. PMID 10823877 DOI: 10.1128/Jvi.74.12.5691-5701.2000  0.393
2000 Pöhlmann S, Lee B, Meister S, Krumbiegel M, Leslie G, Doms RW, Kirchhoff F. Simian immunodeficiency virus utilizes human and sooty mangabey but not rhesus macaque STRL33 for efficient entry. Journal of Virology. 74: 5075-82. PMID 10799581 DOI: 10.1128/Jvi.74.11.5075-5082.2000  0.347
2000 Chen P, Flory E, Avots A, Jordan BW, Kirchhoff F, Ludwig S, Rapp UR. Transactivation of naturally occurring HIV-1 long terminal repeats by the JNK signaling pathway. The most frequent naturally occurring length polymorphism sequence introduces a novel binding site for AP-1 factors. The Journal of Biological Chemistry. 275: 20382-90. PMID 10764760 DOI: 10.1074/Jbc.M001149200  0.349
2000 Carl S, Iafrate AJ, Lang SM, Stolte N, Stahl-Hennig C, Mätz-Rensing K, Fuchs D, Skowronski J, Kirchhoff F. Simian immunodeficiency virus containing mutations in N-terminal tyrosine residues and in the PxxP motif in Nef replicates efficiently in rhesus macaques. Journal of Virology. 74: 4155-64. PMID 10756028 DOI: 10.1128/Jvi.74.9.4155-4164.2000  0.307
2000 Fuss B, Mallon B, Phan T, Ohlemeyer C, Kirchhoff F, Nishiyama A, Macklin WB. Purification and analysis of in vivo-differentiated oligodendrocytes expressing the green fluorescent protein. Developmental Biology. 218: 259-74. PMID 10656768 DOI: 10.1006/Dbio.1999.9574  0.308
2000 Iafrate AJ, Carl S, Bronson S, Stahl-Hennig C, Swigut T, Skowronski J, Kirchhoff F. Disrupting Surfaces of Nef Required for Downregulation of CD4 and for Enhancement of Virion Infectivity Attenuates Simian Immunodeficiency Virus Replication In Vivo Journal of Virology. 74: 12002-12002. DOI: 10.1128/Jvi.74.24.12002-12002.2000  0.319
1999 Condorelli DF, Conti F, Gallo V, Kirchhoff F, Seifert G, Steinhäuser C, Verkhratsky A, Yuan X. Expression and functional analysis of glutamate receptors in glial cells. Advances in Experimental Medicine and Biology. 468: 49-67. PMID 10635019 DOI: 10.1007/978-1-4615-4685-6_5  0.367
1999 Greenough TC, Brettler DB, Kirchhoff F, Alexander L, Desrosiers RC, O'Brien SJ, Somasundaran M, Luzuriaga K, Sullivan JL. Long-term nonprogressive infection with human immunodeficiency virus type 1 in a hemophilia cohort. The Journal of Infectious Diseases. 180: 1790-802. PMID 10558933 DOI: 10.1086/315128  0.396
1999 Pöhlmann S, Stolte N, Münch J, Ten Haaft P, Heeney JL, Stahl-Hennig C, Kirchhoff F. Co-receptor usage of BOB/GPR15 in addition to CCR5 has no significant effect on replication of simian immunodeficiency virus in vivo. The Journal of Infectious Diseases. 180: 1494-502. PMID 10515808 DOI: 10.1086/315097  0.384
1999 Kirchhoff F, Münch J, Carl S, Stolte N, Mätz-Rensing K, Fuchs D, Haaft PT, Heeney JL, Swigut T, Skowronski J, Stahl-Hennig C. The human immunodeficiency virus type 1 nef gene can to a large extent replace simian immunodeficiency virus nef in vivo. Journal of Virology. 73: 8371-83. PMID 10482588 DOI: 10.1128/Jvi.73.10.8371-8383.1999  0.368
1999 Kirchhoff F, Easterbrook PJ, Douglas N, Troop M, Greenough TC, Weber J, Carl S, Sullivan JL, Daniels RS. Sequence variations in human immunodeficiency virus type 1 Nef are associated with different stages of disease. Journal of Virology. 73: 5497-508. PMID 10364298 DOI: 10.1128/Jvi.73.7.5497-5508.1999  0.39
1999 Lock M, Greenberg ME, Iafrate AJ, Swigut T, Muench J, Kirchhoff F, Shohdy N, Skowronski J. Two elements target SIV Nef to the AP-2 clathrin adaptor complex, but only one is required for the induction of CD4 endocytosis. The Embo Journal. 18: 2722-33. PMID 10329619 DOI: 10.1093/Emboj/18.10.2722  0.336
1999 Carl S, Iafrate AJ, Lang SM, Stahl-Hennig C, Kuhn EM, Fuchs D, Mätz-Rensing K, ten Haaft P, Heeney JL, Skowronski J, Kirchhoff F. The acidic region and conserved putative protein kinase C phosphorylation site in Nef are important for SIV replication in rhesus macaques. Virology. 257: 138-55. PMID 10208928 DOI: 10.1006/Viro.1999.9645  0.348
1999 Carl S, Iafrate AJ, Skowronski J, Stahl-Hennig C, Kirchhoff F. Effect of the attenuating deletion and of sequence alterations evolving in vivo on simian immunodeficiency virus C8-Nef function. Journal of Virology. 73: 2790-7. PMID 10074126 DOI: 10.1128/Jvi.73.4.2790-2797.1999  0.349
1999 Kirchhoff F, Carl S, Sopper S, Sauermann U, Mätz-Rensing K, Stahl-Hennig C. Selection of the R17Y substitution in SIVmac239 nef coincided with a dramatic increase in plasma viremia and rapid progression to death. Virology. 254: 61-70. PMID 9927574 DOI: 10.1006/Viro.1998.9522  0.336
1998 Pöhlmann S, Flöss S, Ilyinskii PO, Stamminger T, Kirchhoff F. Sequences just upstream of the simian immunodeficiency virus core enhancer allow efficient replication in the absence of NF-kappaB and Sp1 binding elements. Journal of Virology. 72: 5589-98. PMID 9621017 DOI: 10.1128/Jvi.72.7.5589-5598.1998  0.317
1997 Nolte C, Kirchhoff F, Kettenmann H. Epidermal growth factor is a motility factor for microglial cells in vitro: evidence for EGF receptor expression. The European Journal of Neuroscience. 9: 1690-8. PMID 9283823 DOI: 10.1111/J.1460-9568.1997.Tb01526.X  0.322
1997 Kirchhoff F, Pöhlmann S, Hamacher M, Means RE, Kraus T, Uberla K, Di Marzio P. Simian immunodeficiency virus variants with differential T-cell and macrophage tropism use CCR5 and an unidentified cofactor expressed in CEMx174 cells for efficient entry. Journal of Virology. 71: 6509-16. PMID 9261370 DOI: 10.1128/Jvi.71.9.6509-6516.1997  0.389
1997 Kirchhoff F, Greenough TC, Hamacher M, Sullivan JL, Desrosiers RC. Activity of human immunodeficiency virus type 1 promoter/TAR regions and tat1 genes derived from individuals with different rates of disease progression. Virology. 232: 319-31. PMID 9191845 DOI: 10.1006/Viro.1997.8586  0.335
1997 Kirchhoff F, Ohlemeyer C, Kettenmann H. Expression of myelin-associated glycoprotein transcripts in murine oligodendrocytes. Neuroscience. 78: 561-70. PMID 9145810 DOI: 10.1016/S0306-4522(96)00586-6  0.312
1996 Mariani R, Kirchhoff F, Greenough TC, Sullivan JL, Desrosiers RC, Skowronski J. High frequency of defective nef alleles in a long-term survivor with nonprogressive human immunodeficiency virus type 1 infection. Journal of Virology. 70: 7752-64. PMID 8892896 DOI: 10.1128/Jvi.70.11.7752-7764.1996  0.368
1996 Kirchhoff F, Mülhardt C, Pastor A, Becker CM, Kettenmann H. Expression of glycine receptor subunits in glial cells of the rat spinal cord. Journal of Neurochemistry. 66: 1383-90. PMID 8627289 DOI: 10.1046/J.1471-4159.1996.66041383.X  0.305
1995 Kirchhoff F, Greenough TC, Brettler DB, Sullivan JL, Desrosiers RC. Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection. The New England Journal of Medicine. 332: 228-32. PMID 7808489 DOI: 10.1056/Nejm199501263320405  0.367
1995 Morrison HG, Kirchhoff F, Desrosiers RC. Effects of mutations in constant regions 3 and 4 of envelope of simian immunodeficiency virus. Virology. 210: 448-55. PMID 7618279 DOI: 10.1006/Viro.1995.1361  0.328
1994 Kirchhoff F, Mori K, Desrosiers RC. The "V3" domain is a determinant of simian immunodeficiency virus cell tropism. Journal of Virology. 68: 3682-92. PMID 8189506 DOI: 10.1128/Jvi.68.6.3682-3692.1994  0.353
1994 Greenough TC, Somasundaran M, Brettler DB, Hesselton RM, Alimenti A, Kirchhoff F, Panicali D, Sullivan JL. Normal immune function and inability to isolate virus in culture in an individual with long-term human immunodeficiency virus type 1 infection. Aids Research and Human Retroviruses. 10: 395-403. PMID 8068417 DOI: 10.1089/Aid.1994.10.395  0.352
1994 Kirchhoff F, Morrison HG, Murray MG, Rennert P, Desrosiers RC. SIVmac expressing hybrid envelope proteins containing HIV-1 V3 and/or C4 sequences is not competent for replication. Aids Research and Human Retroviruses. 10: 309-13. PMID 8018392 DOI: 10.1089/Aid.1994.10.309  0.375
1993 Morrison HG, Kirchhoff F, Desrosiers RC. Evidence for the cooperation of gp120 amino acids 322 and 448 in SIVmac entry. Virology. 195: 167-74. PMID 8317093 DOI: 10.1006/Viro.1993.1357  0.318
1993 Kirchhoff F, Hofer HW, Schachner M. Myelin-associated glycoprotein is phosphorylated by protein kinase C. Journal of Neuroscience Research. 36: 368-81. PMID 7505837 DOI: 10.1002/Jnr.490360403  0.307
1992 Kirchhoff F, Hunsmann G. The negative (?) factor of HIV and SIV. Research in Virology. 143: 66-9. PMID 1565862 DOI: 10.1016/S0923-2516(06)80084-1  0.328
1992 Voss G, Kirchhoff F, Nick S, Moosmayer D, Gelderblom H, Hunsmann G. Morphogenesis of recombinant HIV-2 gag core particles. Virus Research. 24: 197-210. PMID 1529643 DOI: 10.1016/0168-1702(92)90007-V  0.35
1992 Daniel MD, Kirchhoff F, Czajak SC, Sehgal PK, Desrosiers RC. Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene. Science (New York, N.Y.). 258: 1938-41. PMID 1470917 DOI: 10.1126/Science.1470917  0.327
1991 Schneider-Schaulies J, Kirchhoff F, Archelos J, Schachner M. Down-regulation of myelin-associated glycoprotein on Schwann cells by interferon-gamma and tumor necrosis factor-alpha affects neurite outgrowth. Neuron. 7: 995-1005. PMID 1722413 DOI: 10.1016/0896-6273(91)90344-Y  0.301
1991 Kirchhoff F, Voss G, Nick S, Stahl-Hennig C, Coulibaly C, Frank R, Jentsch KD, Hunsmann G. Antibody response to the negative regulatory factor (nef) in experimentally infected macaques: correlation with viremia, disease progression, and seroconversion to structural viral proteins. Virology. 183: 267-72. PMID 1675823 DOI: 10.1016/0042-6822(91)90139-3  0.313
1990 Stahl-Hennig C, Herchenröder O, Nick S, Evers M, Stille-Siegener M, Jentsch KD, Kirchhoff F, Tolle T, Gatesman TJ, Lüke W. Experimental infection of macaques with HIV-2ben, a novel HIV-2 isolate. Aids (London, England). 4: 611-7. PMID 2397054 DOI: 10.1097/00002030-199007000-00001  0.335
1990 Kirchhoff F, Jentsch KD, Bachmann B, Stuke A, Laloux C, Lüke W, Stahl-Hennig C, Schneider J, Nieselt K, Eigen M. A novel proviral clone of HIV-2: biological and phylogenetic relationship to other primate immunodeficiency viruses. Virology. 177: 305-11. PMID 2353457 DOI: 10.1016/0042-6822(90)90484-9  0.373
1990 Kirchhoff F, Jentsch KD, Stuke A, Mous J, Hunsmann G. Genomic divergence of an HIV-2 from a German AIDS patient probably infected in Mali. Aids (London, England). 4: 847-57. PMID 2252559 DOI: 10.1097/00002030-199009000-00003  0.346
1990 Schneider J, Lüke W, Kirchhoff F, Jung R, Jurkiewicz E, Stahl-Hennig C, Nick S, Klemm E, Jentsch KD, Hunsmann G. Isolation and characterization of HIV-2ben obtained from a patient with predominantly neurological defects. Aids (London, England). 4: 455-7. PMID 2115342 DOI: 10.1097/00002030-199005000-00012  0.324
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