| Year |
Citation |
Score |
| 2024 |
Gampala S, Moon HR, Wireman R, Peil J, Kiran S, Mitchell DK, Brewster K, Mang H, Masters A, Bach C, Smith-Kinnamen W, Doud EH, Rai R, Mosley AL, Quinney SK, ... ... Kelley MR, et al. New Ref-1/APE1 targeted inhibitors demonstrating improved potency for clinical applications in multiple cancer types. Pharmacological Research. 107092. PMID 38311014 DOI: 10.1016/j.phrs.2024.107092 |
0.307 |
|
| 2023 |
Mijit M, Boner M, Cordova RA, Gampala S, Kpenu E, Klunk AJ, Zhang C, Kelley MR, Staschke KA, Fishel ML. Activation of the integrated stress response (ISR) pathways in response to Ref-1 inhibition in human pancreatic cancer and its tumor microenvironment. Frontiers in Medicine. 10: 1146115. PMID 37181357 DOI: 10.3389/fmed.2023.1146115 |
0.322 |
|
| 2023 |
Mijit M, Liu S, Sishtla K, Hartman GD, Wan J, Corson TW, Kelley MR. Identification of Novel Pathways Regulated by APE1/Ref-1 in Human Retinal Endothelial Cells. International Journal of Molecular Sciences. 24. PMID 36674619 DOI: 10.3390/ijms24021101 |
0.385 |
|
| 2022 |
Behrouzi A, Kelley MR, Fehrenbacher JC. Oxidative DNA Damage: A Role in Altering Neuronal Function. Journal of Cellular Signaling. 3: 160-166. PMID 36204460 DOI: 10.33696/signaling.3.079 |
0.374 |
|
| 2022 |
Mijit M, Wireman R, Armstrong L, Gampala S, Hassan Z, Schneeweis C, Schneider G, Zhang C, Fishel ML, Kelley MR. RelA Is an Essential Target for Enhancing Cellular Responses to the DNA Repair/Ref-1 Redox Signaling Protein and Restoring Perturbated Cellular Redox Homeostasis in Mouse PDAC Cells. Frontiers in Oncology. 12: 826617. PMID 35402225 DOI: 10.3389/fonc.2022.826617 |
0.375 |
|
| 2022 |
Behrouzi A, Xia H, Thompson EL, Kelley MR, Fehrenbacher JC. Oxidative DNA Damage and Cisplatin Neurotoxicity Is Exacerbated by Inhibition of OGG1 Glycosylase Activity and APE1 Endonuclease Activity in Sensory Neurons. International Journal of Molecular Sciences. 23. PMID 35163831 DOI: 10.3390/ijms23031909 |
0.393 |
|
| 2021 |
Gampala S, Shah F, Lu X, Moon HR, Babb O, Ganesh NU, Sandusky G, Hulsey E, Armstrong L, Mosely AL, Han B, Ivan M, Yeh JJ, Kelley MR, Zhang C, et al. Ref-1 redox activity alters cancer cell metabolism in pancreatic cancer: exploiting this novel finding as a potential target. Journal of Experimental & Clinical Cancer Research : Cr. 40: 251. PMID 34376225 DOI: 10.1186/s13046-021-02046-x |
0.343 |
|
| 2020 |
Caston RA, Gampala S, Armstrong L, Messmann RA, Fishel ML, Kelley MR. The multifunctional APE1 DNA repair-redox signaling protein as a drug target in human disease. Drug Discovery Today. PMID 33148489 DOI: 10.1016/j.drudis.2020.10.015 |
0.368 |
|
| 2020 |
Sahakian L, Filippone RT, Stavely R, Robinson AM, Yan XS, Abalo R, Eri R, Bornstein JC, Kelley MR, Nurgali K. Inhibition of APE1/Ref-1 Redox Signaling Alleviates Intestinal Dysfunction and Damage to Myenteric Neurons in a Mouse Model of Spontaneous Chronic Colitis. Inflammatory Bowel Diseases. PMID 32618996 DOI: 10.1093/Ibd/Izaa161 |
0.313 |
|
| 2019 |
Codrich M, Comelli M, Malfatti MC, Mio C, Ayyildiz D, Zhang C, Kelley MR, Terrosu G, Pucillo CEM, Tell G. Inhibition of APE1-endonuclease activity affects cell metabolism in colon cancer cells via a p53-dependent pathway. Dna Repair. 82: 102675. PMID 31450087 DOI: 10.1016/J.Dnarep.2019.102675 |
0.426 |
|
| 2019 |
Fishel ML, Xia H, McGeown J, McIlwain DW, Elbanna M, Craft AA, Kaimakliotis HZ, Sandusky GE, Zhang C, Pili R, Kelley MR, Jerde TJ. Anti-tumor activity and mechanistic characterization of APE1/Ref-1 inhibitors in bladder cancer. Molecular Cancer Therapeutics. PMID 31413178 DOI: 10.1158/1535-7163.Mct-18-1166 |
0.446 |
|
| 2019 |
Frossi B, Antoniali G, Yu K, Akhtar N, Kaplan MH, Kelley MR, Tell G, Pucillo CEM. Endonuclease and redox activities of human apurinic/apyrimidinic endonuclease 1 have distinctive and essential functions in IgA class switch recombination. The Journal of Biological Chemistry. PMID 30705092 DOI: 10.1074/Jbc.Ra118.006601 |
0.468 |
|
| 2019 |
Trilles R, Beglov D, Chen Q, He H, Wireman R, Reed A, Chennamadhavuni S, Panek JS, Brown LE, Vajda S, Porco JA, Kelley MR, Georgiadis MM. Discovery of macrocyclic inhibitors of Apurinic/apyrimidinic endonuclease 1. Journal of Medicinal Chemistry. PMID 30653918 DOI: 10.1021/Acs.Jmedchem.8B01529 |
0.518 |
|
| 2019 |
Chu L, Anderson AKL, Landers MA, Wang Y, Kelley MR, Messmann RA. CTC enumeration and characterization as a pharmacodynamic marker in the phase I clinical study of APX3330, an APE1/Ref-1 inhibitor, in patients with advanced solid tumors. Journal of Clinical Oncology. 37. DOI: 10.1200/Jco.2019.37.15_Suppl.E14531 |
0.381 |
|
| 2019 |
Shahda S, Lakhani NJ, O'Neil B, Rasco DW, Wan J, Mosley AL, Liu H, Kelley MR, Messmann RA. A phase I study of the APE1 protein inhibitor APX3330 in patients with advanced solid tumors. Journal of Clinical Oncology. 37: 3097-3097. DOI: 10.1200/Jco.2019.37.15_Suppl.3097 |
0.346 |
|
| 2019 |
Kelley MR, Shahda S, Lakhani NJ, O'Neil B, Chu L, Anderson AK, Wan J, Mosley AL, Liu H, Messmann RA. Abstract PR01: A phase I study targeting the APE1/Ref-1 DNA repair-redox signaling protein with the APX3330 inhibitor Molecular Cancer Therapeutics. 18. DOI: 10.1158/1535-7163.Targ-19-Pr01 |
0.46 |
|
| 2018 |
Cai Z, Kotzin JJ, Ramdas B, Chen S, Nelanuthala S, Palam LR, Pandey R, Mali RS, Liu Y, Kelley MR, Sandusky G, Mohseni M, Williams A, Henao-Mejia J, Kapur R. Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis. Cell Stem Cell. 23: 833-849.e5. PMID 30526882 DOI: 10.1016/J.Stem.2018.10.013 |
0.329 |
|
| 2018 |
Logsdon DP, Shah F, Carta F, Supuran CT, Kamocka M, Jacobsen MH, Sandusky GE, Kelley MR, Fishel ML. Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival. Scientific Reports. 8: 13759. PMID 30214007 DOI: 10.1038/S41598-018-32034-9 |
0.371 |
|
| 2018 |
Sardar Pasha SPB, Sishtla K, Sulaiman RS, Park B, Shetty T, Shah F, Fishel ML, Wikel JH, Kelley MR, Corson TW. Ref-1/APE1 inhibition with novel small molecules blocks ocular neovascularization. The Journal of Pharmacology and Experimental Therapeutics. PMID 30076264 DOI: 10.1124/Jpet.118.248088 |
0.398 |
|
| 2018 |
McIlwain DW, Fishel ML, Boos A, Kelley MR, Jerde TJ. APE1/Ref-1 redox-specific inhibition decreases survivin protein levels and induces cell cycle arrest in prostate cancer cells. Oncotarget. 9: 10962-10977. PMID 29541389 DOI: 10.18632/Oncotarget.23493 |
0.38 |
|
| 2018 |
Kelley MR, Messmann RA, Fehrenbacher J. Novel first-in-class small molecule targeting APE1/Ref-1 to prevent and treat chemotherapy-induced peripheral neuropathy (CIPN). Journal of Clinical Oncology. 36: 229-229. DOI: 10.1200/Jco.2018.36.34_Suppl.229 |
0.523 |
|
| 2018 |
Cai Z, Kotzin J, Ramdas B, Chen S, Nelanuthala S, Palam LR, Pandey R, Mali R, Liu Y, Kelley MR, Sandusky G, Mohseni M, Williams A, Henao-Mejia J, Kapur R. Downregulation of Morrbid in Tet2-Deficient Preleukemic Cells Overcomes Resistance to Inflammatory Stress and Mitigates Clonal Hematopoiesis Blood. 132: 1288-1288. DOI: 10.1182/Blood-2018-99-116703 |
0.337 |
|
| 2018 |
Shah FL, Atallah N, Grimard M, Guo C, Zhang C, Fehrenbacher J, Kelley MR, Fishel M. Abstract 4802: Combination therapy in PDAC involving blockade of the APE1/Ref-1 signaling pathway: An investigation into drug synthetic lethality and anti-neuropathy therapeutic approach Cancer Research. 78: 4802-4802. DOI: 10.1158/1538-7445.Am2018-4802 |
0.482 |
|
| 2017 |
Fehrenbacher JC, Guo C, Kelley MR, Vasko MR. DNA damage mediates changes in neuronal sensitivity induced by the inflammatory mediators, MCP-1 and LPS, and can be reversed by enhancing the DNA repair function of APE1. Neuroscience. PMID 28965839 DOI: 10.1016/J.Neuroscience.2017.09.039 |
0.432 |
|
| 2017 |
Shah F, Goossens E, Atallah NM, Grimard M, Kelley MR, Fishel ML. APE1/Ref-1 knockdown in pancreatic ductal adenocarcinoma: Characterizing gene expression changes and identifying novel pathways using single-cell RNA sequencing. Molecular Oncology. PMID 28922540 DOI: 10.1002/1878-0261.12138 |
0.412 |
|
| 2017 |
Shah F, Logsdon D, Messmann RA, Fehrenbacher JC, Fishel ML, Kelley MR. Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinic. Npj Precision Oncology. 1. PMID 28825044 DOI: 10.1038/s41698-017-0023-0 |
0.337 |
|
| 2017 |
Ding J, Fishel ML, Reed AM, McAdams E, Czader M, Cardoso AA, Kelley MR. Ref-1/APE1 as Transcriptional Regulator and Novel Therapeutic Target in Pediatric T-cell Leukemia. Molecular Cancer Therapeutics. PMID 28446640 DOI: 10.1158/1535-7163.Mct-17-0099 |
0.364 |
|
| 2017 |
Kelley MR, Fehrenbacher JC. Challenges and opportunities identifying therapeutic targets for chemotherapy-induced peripheral neuropathy resulting from oxidative DNA damage. Neural Regeneration Research. 12: 72-74. PMID 28250749 DOI: 10.4103/1673-5374.198986 |
0.455 |
|
| 2016 |
Kelley MR, Wikel JH, Guo C, Pollok KE, Bailey BJ, Wireman R, Fishel ML, Vasko MR. Identification of new chemical entities targeting APE1 for the prevention of chemotherapy-induced peripheral neuropathy (CIPN). The Journal of Pharmacology and Experimental Therapeutics. PMID 27608656 DOI: 10.1124/Jpet.116.235283 |
0.453 |
|
| 2016 |
Logsdon DP, Grimard M, Luo M, Shahda S, Jiang Y, Tong Y, Yu Z, Zyromski N, Schipani E, Carta F, Supuran CT, Korc M, Ivan M, Kelley MR, Fishel ML. Regulation of HIF1α under Hypoxia by APE1/Ref-1 Impacts CA9 Expression: Dual-Targeting in Patient-Derived 3D Pancreatic Cancer Models. Molecular Cancer Therapeutics. PMID 27535970 DOI: 10.1158/1535-7163.Mct-16-0253 |
0.462 |
|
| 2016 |
Georgiadis MM, Chen Q, Meng J, Guo C, Wireman R, Reed A, Vasko MR, Kelley MR. Small molecule activation of apurinic/apyrimidinic endonuclease 1 reduces DNA damage induced by cisplatin in cultured sensory neurons. Dna Repair. 41: 32-41. PMID 27078577 DOI: 10.1016/J.Dnarep.2016.03.009 |
0.474 |
|
| 2016 |
McElyea KC, Jacobsen MH, Schmidt M, Cheng H, Kelley MR, Sandusky GE, Fishel ML. Abstract 5183: Efficacy study of APX3330, a Ref-1 redox inhibitor, and Gemcitabine in a mouse pancreatic ductal adenocarcinoma model Cancer Research. 76: 5183-5183. DOI: 10.1158/1538-7445.Am2016-5183 |
0.527 |
|
| 2016 |
Fishel ML, Logsdon DP, Grimard ML, Supuran CT, Zyromski N, Ivan M, Kelley MR, Shah F. Abstract 4740: Targeting Ref-1/APE1 pathway inhibition in pancreatic cancer using APX3330 for clinical trials Cancer Research. 76: 4740-4740. DOI: 10.1158/1538-7445.Am2016-4740 |
0.403 |
|
| 2015 |
Kim HS, Guo C, Thompson EL, Jiang Y, Kelley MR, Vasko MR, Lee SH. APE1, the DNA base excision repair protein, regulates the removal of platinum adducts in sensory neuronal cultures by NER. Mutation Research. 779: 96-104. PMID 26164266 DOI: 10.1016/J.Mrfmmm.2015.06.010 |
0.478 |
|
| 2015 |
Fishel ML, Wu X, Devlin CM, Logsdon DP, Jiang Y, Luo M, He Y, Yu Z, Tong Y, Lipking KP, Maitra A, Rajeshkumar NV, Scandura G, Kelley MR, Ivan M. Apurinic/apyrimidinic endonuclease/redox factor-1 (APE1/Ref-1) redox function negatively regulates NRF2. The Journal of Biological Chemistry. 290: 3057-68. PMID 25492865 DOI: 10.1074/Jbc.M114.621995 |
0.499 |
|
| 2015 |
Fishel ML, Cheng H, Korc M, Kelley MR. Abstract B19: Redox factor 1 (Ref-1) signaling in the interaction between pancreatic tumor cells and cancer-associated fibroblasts Cancer Research. 75. DOI: 10.1158/1538-7445.Panca2014-B19 |
0.409 |
|
| 2015 |
Logsdon DP, Cheng H, Luo M, Shahda S, Hao Y, Tong Y, Yu Z, Zyromski N, Schipani E, Liu Y, Supuran CT, Ivan M, Kelley MR, Fishel ML. Abstract B158: Targeting APE1/Ref-1 results in inhibition of hypoxia signaling genes Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-B158 |
0.302 |
|
| 2015 |
Kim HS, Guo C, Thompson EL, Jiang Y, Kelley MR, Vasko MR, Lee SH. APE1, the DNA base excision repair protein, regulates the removal of platinum adducts in sensory neuronal cultures by NER Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 779: 96-104. DOI: 10.1016/j.mrfmmm.2015.06.010 |
0.314 |
|
| 2014 |
Kelley MR, Jiang Y, Guo C, Reed A, Meng H, Vasko MR. Role of the DNA base excision repair protein, APE1 in cisplatin, oxaliplatin, or carboplatin induced sensory neuropathy. Plos One. 9: e106485. PMID 25188410 DOI: 10.1371/Journal.Pone.0106485 |
0.476 |
|
| 2014 |
Li Y, Liu X, Zhou T, Kelley MR, Edwards PA, Gao H, Qiao X. Suppression of choroidal neovascularization through inhibition of APE1/Ref-1 redox activity. Investigative Ophthalmology & Visual Science. 55: 4461-9. PMID 24970265 DOI: 10.1167/Iovs.14-14451 |
0.337 |
|
| 2014 |
Kelley MR, Logsdon D, Fishel ML. Targeting DNA repair pathways for cancer treatment: what's new? Future Oncology (London, England). 10: 1215-37. PMID 24947262 DOI: 10.2217/Fon.14.60 |
0.543 |
|
| 2014 |
Li Y, Liu X, Zhou T, Kelley MR, Edwards P, Gao H, Qiao X. Inhibition of APE1/Ref-1 redox activity rescues human retinal pigment epithelial cells from oxidative stress and reduces choroidal neovascularization. Redox Biology. 2: 485-94. PMID 24624338 DOI: 10.1016/J.Redox.2014.01.023 |
0.352 |
|
| 2014 |
Domenis R, Bergamin N, Gianfranceschi G, Vascotto C, Romanello M, Rigo S, Vagnarelli G, Faggiani M, Parodi P, Kelley MR, Beltrami CA, Cesselli D, Tell G, Beltrami AP. The redox function of APE1 is involved in the differentiation process of stem cells toward a neuronal cell fate. Plos One. 9: e89232. PMID 24586617 DOI: 10.1371/Journal.Pone.0089232 |
0.319 |
|
| 2014 |
Cardoso AA, Wikel JH, Ding J, Reed AM, Luo M, Kelley MR. Abstract B32: First-in-class Ref-1 redox inhibitors for the multipathway targeting of survival signals for relapsed childhood acute lymphoblastic leukemia Cancer Research. 74. DOI: 10.1158/1538-7445.Pedcan-B32 |
0.42 |
|
| 2013 |
Zhang J, Luo M, Marasco D, Logsdon D, LaFavers KA, Chen Q, Reed A, Kelley MR, Gross ML, Georgiadis MM. Inhibition of apurinic/apyrimidinic endonuclease I's redox activity revisited. Biochemistry. 52: 2955-66. PMID 23597102 DOI: 10.1021/Bi400179M |
0.32 |
|
| 2013 |
McIlwain D, Fishel M, Wang L, Snider B, Zhang J, Kelley M, Jerde T. 991 APE1/REF-1 REGULATES SURVIVIN-MEDIATED DRUG RESISTANCE IN PROSTATE CANCER CELLS Journal of Urology. 189. DOI: 10.1016/J.Juro.2013.02.573 |
0.317 |
|
| 2012 |
Cardoso AA, Jiang Y, Luo M, Reed AM, Shahda S, He Y, Maitra A, Kelley MR, Fishel ML. APE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1-STAT3 dual-targeting effectively inhibits pancreatic cancer cell survival. Plos One. 7: e47462. PMID 23094050 DOI: 10.1371/Journal.Pone.0047462 |
0.488 |
|
| 2012 |
Kelley MR, Georgiadis MM, Fishel ML. APE1/Ref-1 role in redox signaling: translational applications of targeting the redox function of the DNA repair/redox protein APE1/Ref-1. Current Molecular Pharmacology. 5: 36-53. PMID 22122463 DOI: 10.2174/1874467211205010036 |
0.493 |
|
| 2012 |
Kumar K, Jackson JL, Kelley MR, Ivan M, Sandsuky G. Abstract 1769: Significant in vivo activity of an APE1/Ref-1 redox inhibitor, E3330, alone and in combination with Bevacizumab in a glioblastoma mouse model analyzed by a whole slide digital imaging system and quantitative immunohistochemistry Cancer Research. 72: 1769-1769. DOI: 10.1158/1538-7445.Am2012-1769 |
0.411 |
|
| 2012 |
Kelley MR. Future Directions with DNA Repair Inhibitors: A Roadmap for Disruptive Approaches to Cancer Therapy Dna Repair in Cancer Therapy. 301-310. DOI: 10.1016/B978-0-12-384999-1.10014-9 |
0.443 |
|
| 2012 |
Kelley MR. Introduction and Overview of DNA Repair Targets: From Bench to Clinic Dna Repair in Cancer Therapy. 1-16. DOI: 10.1016/B978-0-12-384999-1.10001-0 |
0.344 |
|
| 2012 |
Kelley MR. DNA repair in cancer therapy Dna Repair in Cancer Therapy. |
0.338 |
|
| 2011 |
Kelley MR. DNA repair inhibitors: where do we go from here? Dna Repair. 10: 1183-5. PMID 21963404 DOI: 10.1016/J.Dnarep.2011.09.003 |
0.484 |
|
| 2011 |
Vascotto C, Bisetto E, Li M, Zeef LA, D'Ambrosio C, Domenis R, Comelli M, Delneri D, Scaloni A, Altieri F, Mavelli I, Quadrifoglio F, Kelley MR, Tell G. Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function. Molecular Biology of the Cell. 22: 3887-901. PMID 21865600 DOI: 10.1091/Mbc.E11-05-0391 |
0.46 |
|
| 2011 |
Vasko MR, Guo C, Thompson EL, Kelley MR. The repair function of the multifunctional DNA repair/redox protein APE1 is neuroprotective after ionizing radiation. Dna Repair. 10: 942-52. PMID 21741887 DOI: 10.1016/J.Dnarep.2011.06.004 |
0.442 |
|
| 2011 |
Fishel ML, Jiang Y, Rajeshkumar NV, Scandura G, Sinn AL, He Y, Shen C, Jones DR, Pollok KE, Ivan M, Maitra A, Kelley MR. Impact of APE1/Ref-1 redox inhibition on pancreatic tumor growth. Molecular Cancer Therapeutics. 10: 1698-708. PMID 21700832 DOI: 10.1158/1535-7163.Mct-11-0107 |
0.408 |
|
| 2011 |
Onyango DO, Naguleswaran A, Delaplane S, Reed A, Kelley MR, Georgiadis MM, Sullivan WJ. Base excision repair apurinic/apyrimidinic endonucleases in apicomplexan parasite Toxoplasma gondii. Dna Repair. 10: 466-75. PMID 21353648 DOI: 10.1016/J.Dnarep.2011.01.011 |
0.513 |
|
| 2011 |
Rohrabaugh SL, Hangoc G, Kelley MR, Broxmeyer HE. Mad2 haploinsufficiency protects hematopoietic progenitor cells subjected to cell-cycle stress in vivo and to inhibition of redox function of Ape1/Ref-1 in vitro. Experimental Hematology. 39: 415-23. PMID 21216274 DOI: 10.1016/J.Exphem.2010.12.012 |
0.406 |
|
| 2011 |
Su D, Delaplane S, Luo M, Rempel DL, Vu B, Kelley MR, Gross ML, Georgiadis MM. Interactions of apurinic/apyrimidinic endonuclease with a redox inhibitor: evidence for an alternate conformation of the enzyme. Biochemistry. 50: 82-92. PMID 21117647 DOI: 10.1021/Bi101248S |
0.343 |
|
| 2011 |
Jiang A, Gao H, Kelley MR, Qiao X. Inhibition of APE1/Ref-1 redox activity with APX3330 blocks retinal angiogenesis in vitro and in vivo. Vision Research. 51: 93-100. PMID 20937296 DOI: 10.1016/J.Visres.2010.10.008 |
0.317 |
|
| 2011 |
Kelley MR, Luo M, Reed A, Su D, Delaplane S, Borch RF, Nyland RL, Gross ML, Georgiadis MM. Functional analysis of novel analogues of E3330 that block the redox signaling activity of the multifunctional AP endonuclease/redox signaling enzyme APE1/Ref-1. Antioxidants & Redox Signaling. 14: 1387-401. PMID 20874257 DOI: 10.1089/Ars.2010.3410 |
0.43 |
|
| 2011 |
Fishel ML, Jiang Y, Luo M, Reed AM, He Y, Cardoso AM, Kelley MR. Abstract C173: APE1/Ref-1-STAT3 dual-targeting synergize to effectively inhibit pancreatic cancer cell survival. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-C173 |
0.511 |
|
| 2010 |
Jiang Y, Zhou S, Sandusky GE, Kelley MR, Fishel ML. Reduced expression of DNA repair and redox signaling protein APE1/Ref-1 impairs human pancreatic cancer cell survival, proliferation, and cell cycle progression. Cancer Investigation. 28: 885-95. PMID 20919954 DOI: 10.3109/07357907.2010.512816 |
0.476 |
|
| 2010 |
Fishel ML, Colvin ES, Luo M, Kelley MR, Robertson KA. Inhibition of the redox function of APE1/Ref-1 in myeloid leukemia cell lines results in a hypersensitive response to retinoic acid-induced differentiation and apoptosis. Experimental Hematology. 38: 1178-88. PMID 20826193 DOI: 10.1016/J.Exphem.2010.08.011 |
0.412 |
|
| 2010 |
Bapat A, Glass LS, Luo M, Fishel ML, Long EC, Georgiadis MM, Kelley MR. Novel small-molecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells. The Journal of Pharmacology and Experimental Therapeutics. 334: 988-98. PMID 20504914 DOI: 10.1124/Jpet.110.169128 |
0.797 |
|
| 2010 |
Glass LS, Bapat A, Kelley MR, Georgiadis MM, Long EC. Semi-automated high-throughput fluorescent intercalator displacement-based discovery of cytotoxic DNA binding agents from a large compound library. Bioorganic & Medicinal Chemistry Letters. 20: 1685-8. PMID 20144868 DOI: 10.1016/J.Bmcl.2010.01.033 |
0.792 |
|
| 2010 |
Nyland RL, Luo M, Kelley MR, Borch RF. Design and synthesis of novel quinone inhibitors targeted to the redox function of apurinic/apyrimidinic endonuclease 1/redox enhancing factor-1 (Ape1/ref-1). Journal of Medicinal Chemistry. 53: 1200-10. PMID 20067291 DOI: 10.1021/Jm9014857 |
0.443 |
|
| 2010 |
Luo M, He H, Kelley MR, Georgiadis MM. Redox regulation of DNA repair: implications for human health and cancer therapeutic development. Antioxidants & Redox Signaling. 12: 1247-69. PMID 19764832 DOI: 10.1089/Ars.2009.2698 |
0.531 |
|
| 2010 |
Bapat A, Glass LS, Luo M, Fishel ML, Reed A, Long EC, Georgiadis MM, Kelley MR. Abstract 1963: Novel small molecule inhibitor of the endonuclease function of the APE1 DNA repair and redox signaling enzyme blocks proliferation and reduces viability of glioblastoma cells Cellular and Molecular Biology. 70: 1963-1963. DOI: 10.1158/1538-7445.Am10-1963 |
0.797 |
|
| 2009 |
Robertson KA, Colvin ES, Kelley MR, Fishel ML. APX3330 inhibition of the redox function of ape-1/ref-1 (Ref-1) in promyelocytic leukemia cells enhances retinoic acid (ATRA) induced myeloid differentiation and limits cell proliferation as an approach to the prevention of the retinoic acid syndrome (RAS). Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 27: e14613. PMID 27964118 DOI: 10.1200/Jco.2009.27.15_Suppl.E14613 |
0.385 |
|
| 2009 |
Jiang Y, Guo C, Fishel ML, Wang ZY, Vasko MR, Kelley MR. Role of APE1 in differentiated neuroblastoma SH-SY5Y cells in response to oxidative stress: use of APE1 small molecule inhibitors to delineate APE1 functions. Dna Repair. 8: 1273-82. PMID 19726241 DOI: 10.1016/J.Dnarep.2009.08.003 |
0.551 |
|
| 2009 |
Reed AM, Fishel ML, Kelley MR. Small-molecule inhibitors of proteins involved in base excision repair potentiate the anti-tumorigenic effect of existing chemotherapeutics and irradiation. Future Oncology (London, England). 5: 713-26. PMID 19519210 DOI: 10.2217/Fon.09.31 |
0.513 |
|
| 2009 |
Vascotto C, Fantini D, Romanello M, Cesaratto L, Deganuto M, Leonardi A, Radicella JP, Kelley MR, D'Ambrosio C, Scaloni A, Quadrifoglio F, Tell G. APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process. Molecular and Cellular Biology. 29: 1834-54. PMID 19188445 DOI: 10.1128/Mcb.01337-08 |
0.447 |
|
| 2009 |
Vascotto C, Cesaratto L, Zeef LA, Deganuto M, D'Ambrosio C, Scaloni A, Romanello M, Damante G, Taglialatela G, Delneri D, Kelley MR, Mitra S, Quadrifoglio F, Tell G. Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells. Proteomics. 9: 1058-74. PMID 19180539 DOI: 10.1002/Pmic.200800638 |
0.47 |
|
| 2009 |
Tell G, Quadrifoglio F, Tiribelli C, Kelley MR. The many functions of APE1/Ref-1: not only a DNA repair enzyme. Antioxidants & Redox Signaling. 11: 601-20. PMID 18976116 DOI: 10.1089/Ars.2008.2194 |
0.535 |
|
| 2009 |
Bapat A, Fishel ML, Kelley MR. Going ape as an approach to cancer therapeutics. Antioxidants & Redox Signaling. 11: 651-68. PMID 18715143 DOI: 10.1089/Ars.2008.2218 |
0.83 |
|
| 2008 |
Jiang Y, Guo C, Vasko MR, Kelley MR. Implications of apurinic/apyrimidinic endonuclease in reactive oxygen signaling response after cisplatin treatment of dorsal root ganglion neurons. Cancer Research. 68: 6425-34. PMID 18676868 DOI: 10.1158/0008-5472.Can-08-1173 |
0.482 |
|
| 2008 |
Rabik CA, Fishel ML, Holleran JL, Kasza K, Kelley MR, Egorin MJ, Dolan ME. Enhancement of cisplatin [cis-diammine dichloroplatinum (II)] cytotoxicity by O6-benzylguanine involves endoplasmic reticulum stress. The Journal of Pharmacology and Experimental Therapeutics. 327: 442-52. PMID 18664592 DOI: 10.1124/Jpet.108.141291 |
0.431 |
|
| 2008 |
Luo M, Delaplane S, Jiang A, Reed A, He Y, Fishel M, Nyland RL, Borch RF, Qiao X, Georgiadis MM, Kelley MR. Role of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1. Antioxidants & Redox Signaling. 10: 1853-67. PMID 18627350 DOI: 10.1089/Ars.2008.2120 |
0.592 |
|
| 2008 |
Georgiadis MM, Luo M, Gaur RK, Delaplane S, Li X, Kelley MR. Evolution of the redox function in mammalian apurinic/apyrimidinic endonuclease Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 643: 54-63. PMID 18579163 DOI: 10.1016/J.Mrfmmm.2008.04.008 |
0.347 |
|
| 2008 |
Kelley MR, Fishel ML. DNA repair proteins as molecular targets for cancer therapeutics. Anti-Cancer Agents in Medicinal Chemistry. 8: 417-25. PMID 18473726 DOI: 10.2174/187152008784220294 |
0.524 |
|
| 2008 |
Fishel ML, He Y, Reed AM, Chin-Sinex H, Hutchins GD, Mendonca MS, Kelley MR. Knockdown of the DNA repair and redox signaling protein Ape1/Ref-1 blocks ovarian cancer cell and tumor growth. Dna Repair. 7: 177-86. PMID 17974506 DOI: 10.1016/J.Dnarep.2007.09.008 |
0.523 |
|
| 2007 |
Hahn NM, Kelley MR, Klaunig JE, Koch MO, Li L, Sweeney CJ. Constitutional polymorphisms of prostate cancer: prognostic and diagnostic implications. Future Oncology (London, England). 3: 665-82. PMID 18041919 DOI: 10.2217/14796694.3.6.665 |
0.315 |
|
| 2007 |
Harrison JF, Rinne ML, Kelley MR, Druzhyna NM, Wilson GL, Ledoux SP. Altering DNA base excision repair: use of nuclear and mitochondrial-targeted N-methylpurine DNA glycosylase to sensitize astroglia to chemotherapeutic agents. Glia. 55: 1416-25. PMID 17674369 DOI: 10.1002/Glia.20556 |
0.676 |
|
| 2007 |
Fishel ML, Kelley MR. The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive target. Molecular Aspects of Medicine. 28: 375-95. PMID 17560642 DOI: 10.1016/J.Mam.2007.04.005 |
0.595 |
|
| 2007 |
Ho R, Rachek LI, Xu Y, Kelley MR, LeDoux SP, Wilson GL. Yeast apurinic/apyrimidinic endonuclease Apn1 protects mammalian neuronal cell line from oxidative stress Journal of Neurochemistry. 102: 13-24. PMID 17506861 DOI: 10.1111/J.1471-4159.2007.04490.X |
0.4 |
|
| 2007 |
Deganuto M, Pittis MG, Pines A, Dominissini S, Kelley MR, Garcia R, Quadrifoglio F, Bembi B, Tell G. Altered intracellular redox status in Gaucher disease fibroblasts and impairment of adaptive response against oxidative stress. Journal of Cellular Physiology. 212: 223-35. PMID 17443679 DOI: 10.1002/Jcp.21023 |
0.348 |
|
| 2007 |
Fishel ML, He Y, Smith ML, Kelley MR. Manipulation of base excision repair to sensitize ovarian cancer cells to alkylating agent temozolomide. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 260-7. PMID 17200364 DOI: 10.1158/1078-0432.Ccr-06-1920 |
0.536 |
|
| 2007 |
Zou GM, Luo MH, Reed A, Kelley MR, Yoder MC. Ape1 regulates hematopoietic differentiation of embryonic stem cells through its redox functional domain. Blood. 109: 1917-22. PMID 17053053 DOI: 10.1182/Blood-2006-08-044172 |
0.472 |
|
| 2007 |
Fishel ML, Vasko MR, Kelley MR. DNA repair in neurons: so if they don't divide what's to repair? Mutation Research. 614: 24-36. PMID 16879837 DOI: 10.1016/J.Mrfmmm.2006.06.007 |
0.522 |
|
| 2007 |
Reed AM, Fishel ML, Kelley MR, Abonour R. Potentiation of Melphalan-Induced Cytotoxicity through Targeting of the Base Excision Repair Pathway in Multiple Myeloma. Blood. 110: 4799-4799. DOI: 10.1182/Blood.V110.11.4799.4799 |
0.526 |
|
| 2007 |
Robertson KA, Colvin ES, Kelley MR. Inhibition of the Redox Function of Ape-1/ref-1 in Myeloid Leukemia Cells Results in Enhanced Sensitivity to Retinoic Acid Induced Differentiation and Apoptosis. Blood. 110: 4217-4217. DOI: 10.1182/BLOOD.V110.11.4217.4217 |
0.322 |
|
| 2006 |
Wang D, Zhong ZY, Zhang QH, Li ZP, Kelley MR. [Effect of adenoviral N-methylpurine DNA glycosylase overexpression on chemosensitivity of human osteosarcoma cells]. Zhonghua Bing Li Xue Za Zhi Chinese Journal of Pathology. 35: 352-6. PMID 16834910 DOI: 10.3760/J.Issn:0529-5807.2006.06.008 |
0.538 |
|
| 2006 |
Ropolo M, Geroldi A, Degan P, Andreotti V, Zupo S, Poggi A, Reed A, Kelley MR, Frosina G. Accelerated repair and reduced mutagenicity of oxidative DNA damage in human bladder cells expressing the E. coli FPG protein. International Journal of Cancer. Journal International Du Cancer. 118: 1628-34. PMID 16217765 DOI: 10.1002/Ijc.21554 |
0.517 |
|
| 2006 |
Vasko MR, Guo C, Jiang YL, Kelley MR. 5 Enhancing the Expression of the Dna Repair/Redox Enzyme, Ape1/Ref-1, Reduces Neurotoxicity Induced by Ionizing Radiation: Implications for Decreasing Pediatric Neurocognitive Dysfunction. Pediatric Research. 60: 491-491. DOI: 10.1203/00006450-200610000-00027 |
0.324 |
|
| 2006 |
Robertson KA, Colvin ES, Luo M, Reed A, Kelley MR. Ape-1/ref-1 Mediated Redox Regulation of Retinoic Acid Receptor Transcription Function in Myeloid Leukemia Cell Differentiation and Apoptosis. Blood. 108: 1924-1924. DOI: 10.1182/Blood.V108.11.1924.1924 |
0.421 |
|
| 2005 |
Pines A, Perrone L, Bivi N, Romanello M, Damante G, Gulisano M, Kelley MR, Quadrifoglio F, Tell G. Activation of APE1/Ref-1 is dependent on reactive oxygen species generated after purinergic receptor stimulation by ATP. Nucleic Acids Research. 33: 4379-94. PMID 16077024 DOI: 10.1093/Nar/Gki751 |
0.452 |
|
| 2005 |
Rinne ML, He Y, Pachkowski BF, Nakamura J, Kelley MR. N-methylpurine DNA glycosylase overexpression increases alkylation sensitivity by rapidly removing non-toxic 7-methylguanine adducts. Nucleic Acids Research. 33: 2859-67. PMID 15905475 DOI: 10.1093/Nar/Gki601 |
0.678 |
|
| 2005 |
Cai S, Xu Y, Cooper RJ, Ferkowicz MJ, Hartwell JR, Pollok KE, Kelley MR. Mitochondrial targeting of human O6-methylguanine DNA methyltransferase protects against cell killing by chemotherapeutic alkylating agents. Cancer Research. 65: 3319-27. PMID 15833865 DOI: 10.1158/0008-5472.Can-04-3335 |
0.529 |
|
| 2005 |
Pines A, Bivi N, Romanello M, Damante G, Kelley MR, Adamson ED, D'Andrea P, Quadrifoglio F, Moro L, Tell G. Cross-regulation between Egr-1 and APE/Ref-1 during early response to oxidative stress in the human osteoblastic HOBIT cell line: evidence for an autoregulatory loop. Free Radical Research. 39: 269-81. PMID 15788231 DOI: 10.1080/10715760400028423 |
0.516 |
|
| 2005 |
Tell G, Damante G, Caldwell D, Kelley MR. The intracellular localization of APE1/Ref-1: more than a passive phenomenon? Antioxidants & Redox Signaling. 7: 367-84. PMID 15706084 DOI: 10.1089/Ars.2005.7.367 |
0.465 |
|
| 2005 |
Vasko MR, Guo C, Kelley MR. The multifunctional DNA repair/redox enzyme Ape1/Ref-1 promotes survival of neurons after oxidative stress. Dna Repair. 4: 367-79. PMID 15661660 DOI: 10.1016/J.Dnarep.2004.11.006 |
0.351 |
|
| 2005 |
Park SJ, Armstrong S, Kim CH, Yu M, Robertson K, Kelley MR, Lee SH. Lack of EGF receptor contributes to drug sensitivity of human germline cells British Journal of Cancer. 92: 334-341. PMID 15655552 DOI: 10.1038/Sj.Bjc.6602315 |
0.413 |
|
| 2005 |
Guo Y, Einhorn L, Kelley M, Hirota K, Yodoi J, Reinbold R, Scholer H, Ramsey H, Hromas R. Redox regulation of the embryonic stem cell transcription factor oct-4 by thioredoxin. Stem Cells (Dayton, Ohio). 22: 259-64. PMID 15153603 DOI: 10.1634/Stemcells.22-3-259 |
0.434 |
|
| 2004 |
Kremer TM, Rinne ML, Xu Y, Chen XM, Kelley MR. Protection of pulmonary epithelial cells from oxidative stress by hMYH adenine glycosylase. Respiratory Research. 5: 16. PMID 15450125 DOI: 10.1186/1465-9921-5-16 |
0.654 |
|
| 2004 |
Luo M, Kelley MR. Inhibition of the human apurinic/apyrimidinic endonuclease (APE1) repair activity and sensitization of breast cancer cells to DNA alkylating agents with lucanthone. Anticancer Research. 24: 2127-34. PMID 15330152 |
0.494 |
|
| 2004 |
Rinne M, Caldwell D, Kelley MR. Transient adenoviral N-methylpurine DNA glycosylase overexpression imparts chemotherapeutic sensitivity to human breast cancer cells. Molecular Cancer Therapeutics. 3: 955-67. PMID 15299078 |
0.627 |
|
| 2004 |
Wang D, Luo M, Kelley MR. Human apurinic endonuclease 1 (APE1) expression and prognostic significance in osteosarcoma: enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition. Molecular Cancer Therapeutics. 3: 679-86. PMID 15210853 |
0.336 |
|
| 2004 |
Kelley MR, Tompkinson AE, Williams KJ, Drinkwater NR, Fung VA. Frontiers of mutagenesis and DNA repair: a workshop. Cancer Research. 64: 3357-60. PMID 15126381 DOI: 10.1158/0008-5472.Can-04-0373 |
0.473 |
|
| 2004 |
Rinne M, Caldwell D, He Y, Kelley MR. 282. Transient Adenoviral Methylpurine DNA Glycosylase Overexpression Imparts Chemotherapeutic Sensitivity to Human Breast Cancer Cells Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.220 |
0.667 |
|
| 2003 |
Bogliolo M, Cappelli E, D'Osualdo A, Rossi O, Barbieri O, Kelley MR, Frosina G. Effect of S. cerevisiae APN1 protein on mammalian DNA base excision repair. Anticancer Research. 23: 3727-34. PMID 14666670 |
0.43 |
|
| 2003 |
Freitas S, Moore DH, Michael H, Kelley MR. Studies of apurinic/apyrimidinic endonuclease/ref-1 expression in epithelial ovarian cancer: correlations with tumor progression and platinum resistance. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 9: 4689-94. PMID 14581338 |
0.418 |
|
| 2003 |
Cappelli E, D'Osualdo A, Bogliolo M, Kelley MR, Frosina G. Drosophila S3 ribosomal protein accelerates repair of 8-oxoguanine performed by human and mouse cell extracts. Environmental and Molecular Mutagenesis. 42: 50-8. PMID 12874813 DOI: 10.1002/Em.10166 |
0.458 |
|
| 2003 |
Roth TJ, Xu Y, Luo M, Kelley MR. Human-yeast chimeric repair protein protects mammalian cells against alkylating agents: enhancement of MGMT protection. Cancer Gene Therapy. 10: 603-10. PMID 12872142 DOI: 10.1038/Sj.Cgt.7700605 |
0.54 |
|
| 2003 |
Druzhyna NM, Hollensworth SB, Kelley MR, Wilson GL, Ledoux SP. Targeting human 8-oxoguanine glycosylase to mitochondria of oligodendrocytes protects against menadione-induced oxidative stress. Glia. 42: 370-8. PMID 12730957 DOI: 10.1002/Glia.10230 |
0.448 |
|
| 2003 |
Cappelli E, D'Osualdo A, Bogliolo M, Xu Y, Kelley MR, Frosina G. Repair of 8 oxoguanine in mammalian cells expressing the Drosophila S3 ribosomal/repair protein. Teratogenesis, Carcinogenesis, and Mutagenesis. 113-21. PMID 12616602 DOI: 10.1002/Tcm.10067 |
0.451 |
|
| 2003 |
Fishel ML, Seo YR, Smith ML, Kelley MR. Imbalancing the DNA base excision repair pathway in the mitochondria; targeting and overexpressing N-methylpurine DNA glycosylase in mitochondria leads to enhanced cell killing. Cancer Research. 63: 608-15. PMID 12566303 |
0.447 |
|
| 2003 |
Kelley MR, Kow YW, Wilson DM. Disparity between DNA base excision repair in yeast and mammals: translational implications. Cancer Research. 63: 549-54. PMID 12566294 |
0.467 |
|
| 2003 |
Ladd PD, Wilson DM, Kelley MR, Skalnik DG. Identification of the human HEX1/hExo1 gene promoter and characterization of elements responsible for promoter activity. Dna Repair. 2: 187-98. PMID 12531389 DOI: 10.1016/S1568-7864(02)00195-7 |
0.372 |
|
| 2002 |
Bogliolo M, Cappelli E, D'Osualdo A, Rossi O, Barbieri O, Kelley MR, Frosina G. Effect of S. cerevisiae APN1 protein on mammalian DNA base excision repair. Anticancer Research. 22: 2797-804. PMID 12529999 |
0.43 |
|
| 2002 |
Seo YR, Kelley MR, Smith ML. Selenomethionine regulation of p53 by a ref1-dependent redox mechanism. Proceedings of the National Academy of Sciences of the United States of America. 99: 14548-53. PMID 12357032 DOI: 10.1073/Pnas.212319799 |
0.466 |
|
| 2002 |
Rachek LI, Grishko VI, Musiyenko SI, Kelley MR, LeDoux SP, Wilson GL. Conditional targeting of the DNA repair enzyme hOGG1 into mitochondria. The Journal of Biological Chemistry. 277: 44932-7. PMID 12244119 DOI: 10.1074/Jbc.M208770200 |
0.508 |
|
| 2002 |
Wu M, He YH, Kobune M, Xu Y, Kelley MR, Martin WJ. Protection of human lung cells against hyperoxia using the DNA base excision repair genes hOgg1 and Fpg. American Journal of Respiratory and Critical Care Medicine. 166: 192-9. PMID 12119232 DOI: 10.1164/Rccm.200112-130Oc |
0.511 |
|
| 2002 |
Dobson AW, Grishko V, LeDoux SP, Kelley MR, Wilson GL, Gillespie MN. Enhanced mtDNA repair capacity protects pulmonary artery endothelial cells from oxidant-mediated death. American Journal of Physiology. Lung Cellular and Molecular Physiology. 283: L205-10. PMID 12060578 DOI: 10.1152/Ajplung.00443.2001 |
0.421 |
|
| 2002 |
Dobson AW, Kelley MR, Wilson GL, LeDoux SP. Targeting DNA repair proteins to mitochondria. Methods in Molecular Biology (Clifton, N.J.). 197: 351-62. PMID 12013809 DOI: 10.1385/1-59259-284-8:351 |
0.468 |
|
| 2002 |
Seo YR, Fishel ML, Amundson S, Kelley MR, Smith ML. Implication of p53 in base excision DNA repair: in vivo evidence. Oncogene. 21: 731-7. PMID 11850801 DOI: 10.1038/Sj.Onc.1205129 |
0.502 |
|
| 2002 |
Tell G, Pines A, Paron I, D'Elia A, Bisca A, Kelley MR, Manzini G, Damante G. Redox effector factor-1 regulates the activity of thyroid transcription factor 1 by controlling the redox state of the N transcriptional activation domain. The Journal of Biological Chemistry. 277: 14564-74. PMID 11834746 DOI: 10.1074/Jbc.M200582200 |
0.406 |
|
| 2002 |
Puglisi F, Barbone F, Tell G, Aprile G, Pertoldi B, Raiti C, Kelley MR, Damante G, Sobrero A, Beltrami CA, Di Loreto C. Prognostic role of Ape/Ref-1 subcellular expression in stage I-III breast carcinomas. Oncology Reports. 9: 11-7. PMID 11748448 DOI: 10.3892/Or.9.1.11 |
0.319 |
|
| 2002 |
He YH, Xu Y, Kobune M, Wu M, Kelley MR, Martin WJ. Escherichia coli FPG and human OGG1 reduce DNA damage and cytotoxicity by BCNU in human lung cells. American Journal of Physiology. Lung Cellular and Molecular Physiology. 282: L50-5. PMID 11741815 DOI: 10.1152/Ajplung.00316.2001 |
0.419 |
|
| 2001 |
Thomson B, Tritt R, Davis M, Kelley MR. Histology-specific expression of a DNA repair protein in pediatric rhabdomyosarcomas Journal of Pediatric Hematology/Oncology. 23: 234-239. PMID 11846302 DOI: 10.1097/00043426-200105000-00011 |
0.424 |
|
| 2001 |
He YH, Wu M, Kobune M, Xu Y, Kelley MR, Martin WJ. Expression of yeast apurinic/apyrimidinic endonuclease (APN1) protects lung epithelial cells from bleomycin toxicity. American Journal of Respiratory Cell and Molecular Biology. 25: 692-8. PMID 11726394 DOI: 10.1165/Ajrcmb.25.6.4550 |
0.39 |
|
| 2001 |
Schindl M, Oberhuber G, Pichlbauer EG, Obermair A, Birner P, Kelley MR. DNA repair-redox enzyme apurinic endonuclease in cervical cancer: evaluation of redox control of HIF-1alpha and prognostic significance International Journal of Oncology. 19: 799-802. PMID 11562758 DOI: 10.3892/Ijo.19.4.799 |
0.384 |
|
| 2001 |
Kelley MR, Parsons SH. Redox regulation of the DNA repair function of the human AP endonuclease Ape1/ref-1 Antioxidants and Redox Signaling. 3: 671-683. PMID 11554453 DOI: 10.1089/15230860152543014 |
0.531 |
|
| 2001 |
Hsieh MM, Hegde V, Kelley MR, Deutsch WA. Activation of APE/Ref-1 redox activity is mediated by reactive oxygen species and PKC phosphorylation Nucleic Acids Research. 29: 3116-3122. PMID 11452037 DOI: 10.1093/Nar/29.14.3116 |
0.494 |
|
| 2001 |
Kobune M, Xu Y, Baum C, Kelley MR, Williams DA. Retrovirus-mediated expression of the base excision repair proteins, formamidopyrimidine DNA glycosylase or human oxoguanine DNA glycosylase, protects hematopoietic cells from N,N′,N″-triethylenethiophosphoramide (thioTEPA)-induced toxicity in vitro and in vivo Cancer Research. 61: 5116-5125. PMID 11431349 |
0.386 |
|
| 2001 |
Kreklau EL, Limp-Foster M, Liu N, Xu Y, Kelley MR, Erickson LC. A novel fluorometric oligonucleotide assay to measure O( 6)-methylguanine DNA methyltransferase, methylpurine DNA glycosylase, 8-oxoguanine DNA glycosylase and abasic endonuclease activities: DNA repair status in human breast carcinoma cells overexpressing methylpurine DNA glycosylase. Nucleic Acids Research. 29: 2558-66. PMID 11410664 DOI: 10.1093/Nar/29.12.2558 |
0.534 |
|
| 2001 |
Hegde V, Kelley MR, Xu Y, Mian IS, Deutsch WA. Conversion of the Bifunctional 8-Oxoguanine/β-δ Apurinic/Apyrimidinic DNA Repair Activities of Drosophila Ribosomal Protein S3 into the Human S3 Monofunctional β-Elimination Catalyst through a Single Amino Acid Change Journal of Biological Chemistry. 276: 27591-27596. PMID 11353770 DOI: 10.1074/jbc.M101213200 |
0.348 |
|
| 2001 |
Kelley MR, Cheng L, Foster R, Tritt R, Jiang J, Broshears J, Koch M. Elevated and altered expression of the multifunctional DNA base excision repair and redox enzyme Ape1/ref-1 in prostate cancer Clinical Cancer Research. 7: 824-830. PMID 11309329 |
0.313 |
|
| 2001 |
Robertson KA, Bullock HA, Xu Y, Tritt R, Zimmerman E, Ulbright TM, Foster RS, Einhorn LH, Kelley MR. Altered expression of Ape1/ref-1 in germ cell tumors and overexpression in NT2 cells confers resistance to bleomycin and radiation. Cancer Research. 61: 2220-5. PMID 11280790 |
0.478 |
|
| 2001 |
Wu M, Kelley MR, Hansen WK, Martin WJ. Reduction of BCNU toxicity to lung cells by high-level expression of O(6)-methylguanine-DNA methyltransferase. American Journal of Physiology. Lung Cellular and Molecular Physiology. 280: L755-61. PMID 11238017 DOI: 10.1152/Ajplung.2001.280.4.L755 |
0.458 |
|
| 2001 |
Tell G, Crivellato E, Pines A, Paron I, Pucillo C, Manzini G, Bandiera A, Kelley MR, Di Loreto C, Damante G. Mitochondrial localization of APE/Ref-1 in thyroid cells Mutation Research - Dna Repair. 485: 143-152. PMID 11182545 DOI: 10.1016/S0921-8777(00)00068-9 |
0.506 |
|
| 2001 |
Kelley MR, Tritt R, Xu Y, New S, Freie B, Clapp DW, Deutsch WA. The Drosophila S3 multifunctional DNA repair/ribosomal protein protects Fanconi anemia cells against oxidative DNA damaging agents Mutation Research - Dna Repair. 485: 107-119. PMID 11182542 DOI: 10.1016/S0921-8777(00)00067-7 |
0.535 |
|
| 2001 |
Xu Y, Hansen WK, Rosenquist TA, Williams DA, Limp-Foster M, Kelley MR. Protection of mammalian cells against chemotherapeutic agents thiotepa, 1,3-N,N'-bis(2-chloroethyl)-N-nitrosourea, and mafosfamide using the DNA base excision repair genes Fpg and alpha-hOgg1: implications for protective gene therapy applications. The Journal of Pharmacology and Experimental Therapeutics. 296: 825-31. PMID 11181913 |
0.335 |
|
| 2000 |
Evans AR, Limp-Foster M, Kelley MR. Going APE over ref-1 Mutation Research - Dna Repair. 461: 83-108. PMID 11018583 DOI: 10.1016/S0921-8777(00)00046-X |
0.751 |
|
| 2000 |
Hansen WK, Kelley MR. Review of mammalian DNA repair and translational implications. The Journal of Pharmacology and Experimental Therapeutics. 295: 1-9. PMID 10991953 |
0.42 |
|
| 2000 |
Dobson AW, Xu Y, Kelley MR, LeDoux SP, Wilson GL. Enhanced mitochondrial DNA repair and cellular survival after oxidative stress by targeting the human 8-oxoguanine glycosylase repair enzyme to mitochondria. The Journal of Biological Chemistry. 275: 37518-23. PMID 10982789 DOI: 10.1074/Jbc.M000831200 |
0.467 |
|
| 2000 |
Tell G, Pellizzari L, Pucillo C, Puglisi F, Cesselli D, Kelley MR, Di Loreto C, Damante G. TSH controls Ref-1 nuclear translocation in thyroid cells Journal of Molecular Endocrinology. 24: 383-390. PMID 10828831 DOI: 10.1677/Jme.0.0240383 |
0.406 |
|
| 2000 |
Kelley MR, Xu Y, Wilson DM, Deutsch WA. Genomic structure and characterization of the Drosophila S3 ribosomal/DNA repair gene and mutant alleles Dna and Cell Biology. 19: 149-156. PMID 10749167 DOI: 10.1089/104454900314537 |
0.386 |
|
| 2000 |
Limp-Foster M, Kelley MR. DNA repair and gene therapy: Implications for translational uses Environmental and Molecular Mutagenesis. 35: 71-81. PMID 10712740 DOI: 10.1002/(Sici)1098-2280(2000)35:2<71::Aid-Em1>3.0.Co;2-P |
0.727 |
|
| 2000 |
Moore DH, Michael H, Tritt R, Parsons SH, Kelley MR. Alterations in the expression of the DNA repair/redox enzyme APE/ref-1 in epithelial ovarian cancers Clinical Cancer Research. 6: 602-609. PMID 10690545 |
0.413 |
|
| 2000 |
Tell G, Zecca A, Pellizzari L, Spessotto P, Colombatti A, Kelley MR, Damante G, Pucillo C. An 'environment to nucleus' signaling system operates in B lymphocytes: Redox status modulates BSAP/Pax-5 activation through Ref-1 nuclear translocation Nucleic Acids Research. 28: 1099-1105. PMID 10666449 DOI: 10.1093/Nar/28.5.1099 |
0.487 |
|
| 1998 |
Robertson KA, Hill DP, Kelley MR, Tritt R, Crum B, Van Epps S, Srour E, Rice S, Hromas R. The myeloid zinc finger gene (MZF-1) delays retinoic acid-induced apoptosis and differentiation in myeloid leukemia cells Leukemia. 12: 690-698. PMID 9593266 DOI: 10.1038/Sj.Leu.2401005 |
0.333 |
|
| 1998 |
Hansen WK, Deutsch WA, Yacoub A, Xu Y, Williams DA, Kelley MR. Creation of a fully functional human chimeric DNA repair protein. Combining O6-methylguanine DNA methyltransferase (MGMT) and AP endonuclease (APE/redox effector factor 1 (Ref 1)) DNA repair proteins. The Journal of Biological Chemistry. 273: 756-62. PMID 9422728 DOI: 10.1074/Jbc.273.2.756 |
0.522 |
|
| 1997 |
Xu Y, Moore DH, Broshears J, Liu L, Wilson TM, Kelley MR. The apurinic/apyrimidinic endonuclease (APE/ref-1) DNA repair enzyme is elevated in premalignant and malignant cervical cancer. Anticancer Research. 17: 3713-19. PMID 9427767 |
0.402 |
|
| 1997 |
Yacoub A, Kelley MR, Deutsch WA. The DNA repair activity of human redox/repair protein APE/Ref-1 is inactivated by phosphorylation Cancer Research. 57: 5457-5459. PMID 9407949 |
0.387 |
|
| 1997 |
Sandigursky M, Yacoub A, Kelley MR, Xu Y, Franklin WA, Deutsch WA. The yeast 8-oxoguanine DNA glycosylase (Ogg1) contains a DNA deoxyribophosphodiesterase (dRpase) activity Nucleic Acids Research. 25: 4557-4561. PMID 9358166 DOI: 10.1093/Nar/25.22.4557 |
0.503 |
|
| 1997 |
Clawson GA, Benedict CM, Kelley MR, Weisz J. Focal nuclear hepatocyte response to oxidative damage following low dose thioacetamide intoxication Carcinogenesis. 18: 1663-1668. PMID 9276646 DOI: 10.1093/Carcin/18.8.1663 |
0.44 |
|
| 1997 |
Sandigursky M, Yacoub A, Kelley MR, Deutsch WA, Franklin WA. The Drosophila ribosomal protein S3 contains a DNA deoxyribophosphodiesterase (dRpase) activity Journal of Biological Chemistry. 272: 17480-17484. PMID 9211893 DOI: 10.1074/jbc.272.28.17480 |
0.388 |
|
| 1997 |
Robertson KA, Hill DP, Xu Y, Liu L, Van Epps S, Hockenbery DM, Park JR, Wilson TM, Kelley MR. Down-regulation of apurinic/apyrimidinic endonuclease expression is associated with the induction of apoptosis in differentiating myeloid leukemia cells. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 8: 443-9. PMID 9101090 |
0.417 |
|
| 1997 |
Chun KT, Edenberg HJ, Kelley MR, Goebl MG. Rapid amplification of uncharacterized transposon-tagged DNA sequences from genomic DNA Yeast. 13: 233-240. PMID 9090052 DOI: 10.1002/(Sici)1097-0061(19970315)13:3<233::Aid-Yea88>3.0.Co;2-E |
0.41 |
|
| 1997 |
Maze R, Kapur R, Kelley MR, Hansen WK, Oh SY, Williams DA. Reversal of 1,3-bis(2-chloroethyl)-1-nitrosourea-induced severe immunodeficiency by transduction of murine long-lived hemopoietic progenitor cells using O6-methylguanine DNA methyltransferase complementary DNA. Journal of Immunology (Baltimore, Md. : 1950). 158: 1006-13. PMID 8993023 |
0.305 |
|
| 1996 |
Yacoub A, Kelley MR, Deutsch WA. Drosophila ribosomal protein PO contains apurinic/apyrimidinic endonuclease activity Nucleic Acids Research. 24: 4298-4303. PMID 8932386 DOI: 10.1093/Nar/24.21.4298 |
0.486 |
|
| 1996 |
Yacoub A, Augeri L, Kelley MR, Doetsch PW, Deutsch WA. A Drosophila ribosomal protein contains 8-oxoguanine and abasic site DNA repair activities Embo Journal. 15: 2306-2312. PMID 8641296 |
0.437 |
|
| 1996 |
Wilson TM, Rivkees SA, Deutsch WA, Kelley MR. Differential expression of the apurinic / apyrimidinic endonuclease (APE/ref-1) multifunctional DNA base excision repair gene during fetal development and in adult rat brain and testis. Mutation Research. 362: 237-48. PMID 8637502 DOI: 10.1016/0921-8777(95)00053-4 |
0.423 |
|
| 1996 |
Maze R, Carney JP, Kelley MR, Glassner BJ, Williams DA, Samson L. Increasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic alkylating agent Proceedings of the National Academy of Sciences of the United States of America. 93: 206-210. PMID 8552605 DOI: 10.1073/Pnas.93.1.206 |
0.423 |
|
| 1996 |
Yacoub A, Augeri L, Kelley MR, Doetsch PW, Deutsch WA. A Drosophila ribosomal protein contains 8-oxoguanine and abasic site DNA repair activities. The Embo Journal. 15: 2306-2312. DOI: 10.1002/J.1460-2075.1996.Tb00584.X |
0.435 |
|
| 1995 |
Duguid JR, Eble JN, Wilson TM, Kelley MR. Differential cellular and subcellular expression of the human multifunctional apurinic/apyrimidinic endonuclease (APE/ref-1) DNA repair enzyme. Cancer Research. 55: 6097-102. PMID 8521399 |
0.325 |
|
| 1995 |
Wilson TM, Yu-Lee LY, Kelley MR. Coordinate gene expression of luteinizing hormone-releasing hormone (LHRH) and the LHRH-receptor after prolactin stimulation in the rat Nb2 T-cell line: implications for a role in immunomodulation and cell cycle gene expression. Molecular Endocrinology (Baltimore, Md.). 9: 44-53. PMID 7760850 DOI: 10.1210/Mend.9.1.7760850 |
0.351 |
|
| 1995 |
Huq I, Wilson TM, Kelley MR, Deutsch WA. Expression in Escherichia coli of a rat cDNA encoding an apurinic/apyrimidinic endonuclease. Mutation Research. 337: 191-9. PMID 7491122 DOI: 10.1016/0921-8777(95)00024-E |
0.47 |
|
| 1994 |
Pieper RO, Morgan SE, Kelley MR. The role of two conserved amino acids, glutamine 90 and asparagine 137, in O6-methylguanine-DNA methyltransferase stability, activity and substrate specificity. Carcinogenesis. 15: 1895-902. PMID 7923583 DOI: 10.1093/Carcin/15.9.1895 |
0.444 |
|
| 1994 |
Wilson DM, Tentler JJ, Carney JP, Wilson TM, Kelley MR. Acute ethanol exposure suppresses the repair of O6-methylguanine DNA lesions in castrated adult male rats. Alcoholism, Clinical and Experimental Research. 18: 1267-71. PMID 7847618 DOI: 10.1111/J.1530-0277.1994.Tb00117.X |
0.359 |
|
| 1994 |
Rivkees SA, Kelley MR. Expression of a multifunctional DNA repair enzyme gene, apurinic/apyrimidinic endonuclease (APE; Ref-1) in the suprachiasmatic, supraoptic and paraventricular nuclei Brain Research. 666: 137-142. PMID 7534193 DOI: 10.1016/0006-8993(94)90296-8 |
0.487 |
|
| 1994 |
Wilson DM, Deutsch WA, Kelley MR. Drosophila ribosomal protein S3 contains an activity that cleaves DNA at apurinic/apyrimidinic sites. Journal of Biological Chemistry. 269: 25359-25364. DOI: 10.1016/s0021-9258(18)47256-0 |
0.331 |
|
| 1993 |
Wilson DM, Deutsch WA, Kelley MR. Cloning of the Drosophila ribosomal protein S3: another multifunctional ribosomal protein with AP endonuclease DNA repair activity. Nucleic Acids Research. 21: 2516. PMID 7685082 DOI: 10.1093/NAR/21.10.2516 |
0.334 |
|
| 1992 |
Grabowski DT, Pieper RO, Futscher BW, Deutsch WA, Erickson LC, Kelley MR. Expression of ribosomal phosphoprotein PO is induced by antitumor agents and increased in Mer- human tumor cell lines. Carcinogenesis. 13: 259-63. PMID 1740017 DOI: 10.1093/Carcin/13.2.259 |
0.437 |
|
| 1991 |
Grabowski DT, Deutsch WA, Derda D, Kelley MR. Drosophila AP3, a presumptive DNA repair protein, is homologous to human ribosomal associated protein PO Nucleic Acids Research. 19: 4297-4297. PMID 1870984 DOI: 10.1093/Nar/19.15.4297 |
0.429 |
|
| 1991 |
Guzder SN, Kelley MR, Deutsch WA. Drosophila methyltransferase activity and the repair of alkylated DNA. Mutation Research. 255: 143-53. PMID 1717843 DOI: 10.1016/0921-8777(91)90048-T |
0.316 |
|
| 1989 |
Kelley MR, Venugopal S, Harless J, Deutsch WA. Antibody to a human DNA repair protein allows for cloning of a Drosophila cDNA that encodes an apurinic endonuclease. Molecular and Cellular Biology. 9: 965-973. DOI: 10.1128/MCB.9.3.965 |
0.301 |
|
| 1986 |
Russel M, Kidd S, Kelley MR. An improved filamentous helper phage for generating single-stranded plasmid DNA Gene. 45: 333-338. PMID 3026919 DOI: 10.1016/0378-1119(86)90032-6 |
0.336 |
|
| 1983 |
Kelley MR, Lee WR. Mutagenesis in Oocytes of DROSOPHILA MELANOGASTER. I. Scheduled Synthesis of Nuclear and Mitochondrial DNA and Unscheduled DNA Synthesis. Genetics. 104: 279-99. PMID 17246137 |
0.393 |
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