David Dawbarn - Publications

University of Bristol, Bristol, England, United Kingdom 
NGF, Alzheimer's, pain

76 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Shoemark DK, Williams C, Fahey MS, Watson JJ, Tyler SJ, Scoltock SJ, Ellis RZ, Wickenden E, Burton AJ, Hemmings JL, Bailey CD, Dawbarn D, Jane DE, Willis CL, Sessions RB, et al. Design and nuclear magnetic resonance (NMR) structure determination of the second extracellular immunoglobulin tyrosine kinase A (TrkAIg2) domain construct for binding site elucidation in drug discovery. Journal of Medicinal Chemistry. 58: 767-77. PMID 25454499 DOI: 10.1021/jm501307e  0.88
2013 Frias B, Allen S, Dawbarn D, Charrua A, Cruz F, Cruz CD. Brain-derived neurotrophic factor, acting at the spinal cord level, participates in bladder hyperactivity and referred pain during chronic bladder inflammation. Neuroscience. 234: 88-102. PMID 23313710 DOI: 10.1016/j.neuroscience.2012.12.044  0.88
2011 Allen SJ, Watson JJ, Dawbarn D. The neurotrophins and their role in Alzheimer's disease. Current Neuropharmacology. 9: 559-73. PMID 22654716 DOI: 10.2174/157015911798376190  0.88
2010 Cristofaro B, Stone OA, Caporali A, Dawbarn D, Ieronimakis N, Reyes M, Madeddu P, Bates DO, Emanueli C. Neurotrophin-3 is a novel angiogenic factor capable of therapeutic neovascularization in a mouse model of limb ischemia. Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 1143-50. PMID 20360537 DOI: 10.1161/ATVBAHA.109.205468  0.88
2010 McNamee KE, Burleigh A, Gompels LL, Feldmann M, Allen SJ, Williams RO, Dawbarn D, Vincent TL, Inglis JJ. Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain. Pain. 149: 386-92. PMID 20350782 DOI: 10.1016/j.pain.2010.03.002  0.88
2010 Pinto R, Frias B, Allen S, Dawbarn D, McMahon SB, Cruz F, Cruz CD. Sequestration of brain derived nerve factor by intravenous delivery of TrkB-Ig2 reduces bladder overactivity and noxious input in animals with chronic cystitis. Neuroscience. 166: 907-16. PMID 20079809 DOI: 10.1016/j.neuroscience.2010.01.015  0.88
2009 Masoudi R, Ioannou MS, Coughlin MD, Pagadala P, Neet KE, Clewes O, Allen SJ, Dawbarn D, Fahnestock M. Biological activity of nerve growth factor precursor is dependent upon relative levels of its receptors. The Journal of Biological Chemistry. 284: 18424-33. PMID 19389705 DOI: 10.1074/jbc.M109.007104  0.88
2009 Lu VB, Biggs JE, Stebbing MJ, Balasubramanyan S, Todd KG, Lai AY, Colmers WF, Dawbarn D, Ballanyi K, Smith PA. Brain-derived neurotrophic factor drives the changes in excitatory synaptic transmission in the rat superficial dorsal horn that follow sciatic nerve injury. The Journal of Physiology. 587: 1013-32. PMID 19124536 DOI: 10.1113/jphysiol.2008.166306  0.88
2008 Watson JJ, Allen SJ, Dawbarn D. Targeting nerve growth factor in pain: what is the therapeutic potential? Biodrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy. 22: 349-59. PMID 18998753 DOI: 10.2165/0063030-200822060-00002  0.88
2008 Clewes O, Fahey MS, Tyler SJ, Watson JJ, Seok H, Catania C, Cho K, Dawbarn D, Allen SJ. Human ProNGF: biological effects and binding profiles at TrkA, P75NTR and sortilin. Journal of Neurochemistry. 107: 1124-35. PMID 18808449 DOI: 10.1111/j.1471-4159.2008.05698.x  0.88
2007 Hatchett CS, Tyler S, Armstrong D, Dawbarn D, Allen SJ. Familial Alzheimer's disease presenilin 1 mutation M146V increases gamma secretase cutting of p75NTR in vitro. Brain Research. 1147: 248-55. PMID 17349981 DOI: 10.1016/j.brainres.2007.02.002  0.88
2007 Bishop T, Hewson DW, Yip PK, Fahey MS, Dawbarn D, Young AR, McMahon SB. Characterisation of ultraviolet-B-induced inflammation as a model of hyperalgesia in the rat. Pain. 131: 70-82. PMID 17257754 DOI: 10.1016/j.pain.2006.12.014  0.88
2007 Lu VB, Balasubramanyan S, Biggs JE, Stebbing MJ, Gustafson SL, Todd K, Lai A, Dawbarn D, Colmers WF, Ballanyi K, Smith PA. Slow modulation of synaptic transmission by brain-derived neurotrophic factor leads to the central sensitization associated with neuropathic pain Neurophysiology. 39: 272-283. DOI: 10.1007/s11062-007-0038-1  0.88
2006 Nassenstein C, Dawbarn D, Pollock K, Allen SJ, Erpenbeck VJ, Spies E, Krug N, Braun A. Pulmonary distribution, regulation, and functional role of Trk receptors in a murine model of asthma. The Journal of Allergy and Clinical Immunology. 118: 597-605. PMID 16950277 DOI: 10.1016/j.jaci.2006.04.052  0.88
2006 Dawbarn D, Fahey M, Watson J, Tyler S, Shoemark D, Sessions R, Zhang R, Brady L, Willis C, Allen SJ. NGF receptor TrkAd5: therapeutic agent and drug design target. Biochemical Society Transactions. 34: 587-90. PMID 16856868 DOI: 10.1042/BST0340587  0.88
2006 Allen SJ, Dawbarn D. Clinical relevance of the neurotrophins and their receptors. Clinical Science (London, England : 1979). 110: 175-91. PMID 16411894 DOI: 10.1042/CS20050161  0.88
2006 Watson JJ, Fahey MS, van den Worm E, Engels F, Nijkamp FP, Stroemer P, McMahon S, Allen SJ, Dawbarn D. TrkAd5: A novel therapeutic agent for treatment of inflammatory pain and asthma. The Journal of Pharmacology and Experimental Therapeutics. 316: 1122-9. PMID 16284276 DOI: 10.1124/jpet.105.095844  0.88
2006 Love S, Siew LK, Dawbarn D, Wilcock GK, Ben-Shlomo Y, Allen SJ. Premorbid effects of APOE on synaptic proteins in human temporal neocortex. Neurobiology of Aging. 27: 797-803. PMID 15979210 DOI: 10.1016/j.neurobiolaging.2005.04.008  0.88
2005 Hu VY, Zvara P, Dattilio A, Redman TL, Allen SJ, Dawbarn D, Stroemer RP, Vizzard MA. Decrease in bladder overactivity with REN1820 in rats with cyclophosphamide induced cystitis. The Journal of Urology. 173: 1016-21. PMID 15711368 DOI: 10.1097/01.ju.0000155170.15023.e5  0.88
2004 Siew LK, Love S, Dawbarn D, Wilcock GK, Allen SJ. Measurement of pre- and post-synaptic proteins in cerebral cortex: effects of post-mortem delay. Journal of Neuroscience Methods. 139: 153-9. PMID 15488227 DOI: 10.1016/j.jneumeth.2004.04.020  0.88
2003 Dawbarn D, Allen SJ. Neurotrophins and neurodegeneration. Neuropathology and Applied Neurobiology. 29: 211-30. PMID 12787319 DOI: 10.1046/j.1365-2990.2003.00487.x  0.88
2002 Tyler SJ, Dawbarn D, Wilcock GK, Allen SJ. alpha- and beta-secretase: profound changes in Alzheimer's disease. Biochemical and Biophysical Research Communications. 299: 373-6. PMID 12445809 DOI: 10.1016/S0006-291X(02)02635-9  0.88
2002 Naylor RL, Robertson AG, Allen SJ, Sessions RB, Clarke AR, Mason GG, Burston JJ, Tyler SJ, Wilcock GK, Dawbarn D. A discrete domain of the human TrkB receptor defines the binding sites for BDNF and NT-4. Biochemical and Biophysical Research Communications. 291: 501-7. PMID 11855816 DOI: 10.1006/bbrc.2002.6468  0.88
2001 Banfield MJ, Naylor RL, Robertson AG, Allen SJ, Dawbarn D, Brady RL. Specificity in Trk receptor:neurotrophin interactions: the crystal structure of TrkB-d5 in complex with neurotrophin-4/5. Structure (London, England : 1993). 9: 1191-9. PMID 11738045 DOI: 10.1016/S0969-2126(01)00681-5  0.88
2001 Djouhri L, Dawbarn D, Robertson A, Newton R, Lawson SN. Time course and nerve growth factor dependence of inflammation-induced alterations in electrophysiological membrane properties in nociceptive primary afferent neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 8722-33. PMID 11698584  0.88
2001 Robertson AG, Banfield MJ, Allen SJ, Dando JA, Mason GG, Tyler SJ, Bennett GS, Brain SD, Clarke AR, Naylor RL, Wilcock GK, Brady RL, Dawbarn D. Identification and structure of the nerve growth factor binding site on TrkA. Biochemical and Biophysical Research Communications. 282: 131-41. PMID 11263982 DOI: 10.1006/bbrc.2001.4462  0.88
2001 Allen SJ, Robertson AG, Tyler SJ, Wilcock GK, Dawbarn D. Recombinant human nerve growth factor for clinical trials: protein expression, purification, stability and characterisation of binding to infusion pumps. Journal of Biochemical and Biophysical Methods. 47: 239-55. PMID 11245895 DOI: 10.1016/S0165-022X(01)00134-8  0.88
2001 Fahey MS, Dawbarn D, Allen SJ, Paterson IC, Prime SS. Expression of recombinant extracellular domain of the type II transforming growth factor-beta receptor: utilization in a modified enzyme-linked immunoabsorbent assay to screen TGF-beta agonists and antagonists. Analytical Biochemistry. 290: 272-6. PMID 11237329 DOI: 10.1006/abio.2000.4948  0.88
2000 O'Meara G, Coumis U, Ma SY, Kehr J, Mahoney S, Bacon A, Allen SJ, Holmes F, Kahl U, Wang FH, Kearns IR, Ove-Ogren S, Dawbarn D, Mufson EJ, Davies C, et al. Galanin regulates the postnatal survival of a subset of basal forebrain cholinergic neurons. Proceedings of the National Academy of Sciences of the United States of America. 97: 11569-74. PMID 11016971 DOI: 10.1073/pnas.210254597  0.88
2000 Smith SK, Anderson HA, Yu G, Robertson AG, Allen SJ, Tyler SJ, Naylor RL, Mason G, Wilcock GW, Roche PA, Fraser PE, Dawbarn D. Identification of syntaxin 1A as a novel binding protein for presenilin-1. Brain Research. Molecular Brain Research. 78: 100-7. PMID 10891589 DOI: 10.1016/S0169-328X(00)00079-6  0.88
1999 Allen SJ, Wilcock GK, Dawbarn D. Profound and selective loss of catalytic TrkB immunoreactivity in Alzheimer's disease. Biochemical and Biophysical Research Communications. 264: 648-51. PMID 10543986 DOI: 10.1006/bbrc.1999.1561  0.88
1998 Pennypacker KR, Fuldner R, Xu R, Hernandez H, Dawbarn D, Mehta N, Perez-Tur J, Baker M, Hutton M. Cloning and characterization of the presenilin-2 gene promoter. Brain Research. Molecular Brain Research. 56: 57-65. PMID 9602061 DOI: 10.1016/S0169-328X(98)00028-X  0.88
1997 Allen SJ, MacGowan SH, Tyler S, Wilcock GK, Robertson AG, Holden PH, Smith SK, Dawbarn D. Reduced cholinergic function in normal and Alzheimer's disease brain is associated with apolipoprotein E4 genotype. Neuroscience Letters. 239: 33-6. PMID 9547165 DOI: 10.1016/S0304-3940(97)00872-0  0.88
1997 Holden PH, Asopa V, Robertson AG, Clarke AR, Tyler S, Bennett GS, Brain SD, Wilcock GK, Allen SJ, Smith SK, Dawbarn D. Immunoglobulin-like domains define the nerve growth factor binding site of the TrkA receptor. Nature Biotechnology. 15: 668-72. PMID 9219271 DOI: 10.1038/nbt0797-668  0.88
1994 Allen SJ, Dawbarn D, Eckford SD, Wilcock GK, Ashcroft M, Colebrook SM, Feeney R, MacGowan SH. Cloning of a non-catalytic form of human trkB and distribution of messenger RNA for trkB in human brain. Neuroscience. 60: 825-34. PMID 7936202 DOI: 10.1016/0306-4522(94)90507-X  0.88
1991 Allen SJ, MacGowan SH, Treanor JJ, Feeney R, Wilcock GK, Dawbarn D. Normal beta-NGF content in Alzheimer's disease cerebral cortex and hippocampus. Neuroscience Letters. 131: 135-9. PMID 1791973  0.88
1991 Treanor JJ, Dawbarn D, Allen SJ, MacGowan SH, Wilcock GK. Low affinity nerve growth factor receptor binding in normal and Alzheimer's disease basal forebrain. Neuroscience Letters. 121: 73-6. PMID 1708488 DOI: 10.1016/0304-3940(91)90652-A  0.88
1991 Allen SJ, MacGowan SH, Treanor JJS, Feeney R, Wilcock GK, Dawbarn D. Normal β-NGF content in Alzheimer's disease cerebral cortex and hippocampus Neuroscience Letters. 131: 135-139. DOI: 10.1016/0304-3940(91)90354-V  0.88
1990 Allen SJ, Dawbarn D, Macgowan SH, Wikock GK, Treanor JJS, Moss TH. Quantitative morphometric analysis of basal forebrain neurons expressing β-nerve growth factor receptors in normal and alzheimer’s disease brains Dementia and Geriatric Cognitive Disorders. 1: 125-137. DOI: 10.1159/000107132  0.88
1989 Allen SJ, Dawbarn D, Spillantini MG, Goedert M, Wilcock GK, Moss TH, Semenenko FM. Distribution of beta-nerve growth factor receptors in the human basal forebrain. The Journal of Comparative Neurology. 289: 626-40. PMID 2556457 DOI: 10.1002/cne.902890408  0.88
1989 Goedert M, Fine A, Dawbarn D, Wilcock GK, Chao MV. Nerve growth factor receptor mRNA distribution in human brain: normal levels in basal forebrain in Alzheimer's disease. Brain Research. Molecular Brain Research. 5: 1-7. PMID 2538704 DOI: 10.1016/0169-328X(89)90011-9  0.88
1988 Allen SJ, Dawbarn D, Wilcock GK. Morphometric immunochemical analysis of neurons in the nucleus basalis of Meynert in Alzheimer's disease. Brain Research. 454: 275-81. PMID 3409011 DOI: 10.1016/0006-8993(88)90827-X  0.88
1988 Dawbarn D, Allen SJ, Semenenko FM. Coexistence of choline acetyltransferase and nerve growth factor receptors in the rat basal forebrain. Neuroscience Letters. 94: 138-44. PMID 2853851 DOI: 10.1016/0304-3940(88)90284-4  0.88
1988 Dawbarn D, Allen SJ, Semenenko FM. Immunohistochemical localization of beta-nerve growth factor receptors in the forebrain of the rat. Brain Research. 440: 185-9. PMID 2833990 DOI: 10.1016/0006-8993(88)91175-4  0.88
1987 Gray PL, Dawbarn D, Taberner PV. Alterations in dopamine and 5-hydroxytryptamine (5-HT) function during barbiturate dependence and withdrawal in mice. Journal of Psychopharmacology (Oxford, England). 1: 101-8. PMID 22158891 DOI: 10.1177/026988118700100207  0.88
1987 Isacson O, Fischer W, Wictorin K, Dawbarn D, Björklund A. Astroglial response in the excitotoxically lesioned neostriatum and its projection areas in the rat. Neuroscience. 20: 1043-56. PMID 3601061 DOI: 10.1016/0306-4522(87)90262-4  0.88
1987 Lu SM, Schweitzer L, Cant NB, Dawbarn D. Immunoreactivity to calcitonin gene-related peptide in the superior olivary complex and cochlea of cat and rat. Hearing Research. 31: 137-46. PMID 3502259 DOI: 10.1016/0378-5955(87)90119-5  0.88
1987 Isacson O, Pritzel M, Dawbarn D, Brundin P, Kelly PA, Wiklund L, Emson PC, Gage FH, Dunnett SB, Björklund A. Striatal neural transplants in the ibotenic acid-lesioned rat neostriatum. Cellular and functional aspects. Annals of the New York Academy of Sciences. 495: 537-55. PMID 3474959  0.88
1987 Clarke JG, Davies GJ, Kerwin R, Hackett D, Larkin S, Dawbarn D, Lee Y, Bloom SR, Yacoub M, Maseri A. Coronary artery infusion of neuropeptide Y in patients with angina pectoris. Lancet. 1: 1057-9. PMID 2883396 DOI: 10.1016/S0140-6736(87)90483-1  0.88
1987 Isacson O, Dawbarn D, Brundin P, Gage FH, Emson PC, Björklund A. Neural grafting in a rat model of Huntington's disease: striosomal-like organization of striatal grafts as revealed by acetylcholinesterase histochemistry, immunocytochemistry and receptor autoradiography. Neuroscience. 22: 481-97. PMID 2823174 DOI: 10.1016/0306-4522(87)90348-4  0.88
1986 Dawbarn D, Rossor MN, Mountjoy CQ, Roth M, Emson PC. Decreased somatostatin immunoreactivity but not neuropeptide Y immunoreactivity in cerebral cortex in senile dementia of Alzheimer type. Neuroscience Letters. 70: 154-9. PMID 2877420 DOI: 10.1016/0304-3940(86)90455-6  0.88
1986 Dawbarn D, Zamir N, Waters CM, Hunt SP, Emson PC, Brownstein MJ. Peptides derived from prodynorphin are decreased in basal ganglia of Huntington's disease brains. Brain Research. 372: 155-8. PMID 2871898 DOI: 10.1016/0006-8993(86)91469-1  0.88
1986 Rossor M, Emson P, Dawbarn D, Dockray G, Mountjoy C, Roth M. Postmortem studies of peptides in Alzheimer's disease and Huntington's disease. Research Publications - Association For Research in Nervous and Mental Disease. 64: 259-77. PMID 2425405  0.88
1986 Rossor MN, Emson PC, Dawbarn D, Mountjoy CQ, Roth M. Chapter 8 Neuropeptides and dementia Progress in Brain Research. 66: 143-159. DOI: 10.1016/S0079-6123(08)64603-8  0.88
1985 Dawbarn D, Emson PC. Neuropeptide Y-like immunoreactivity in neuritic plaques of Alzheimer's disease. Biochemical and Biophysical Research Communications. 126: 289-94. PMID 3838246 DOI: 10.1016/0006-291X(85)90604-7  0.88
1985 Emson PC, Dawbarn D, Rossor MN, Rehfeld JF, Brundin P, Isacson O, Björklund A. Cholecystokinin content in the basal ganglia in Huntington's disease. The expression of cholecystokinin immunoreactivity in striatal grafts to ibotenic acid-lesioned rat striatum. Annals of the New York Academy of Sciences. 448: 488-94. PMID 3161446  0.88
1985 Dawbarn D, Gregory J, Emson PC. Visualization of calcitonin gene-related peptide receptors in the rat brain. European Journal of Pharmacology. 111: 407-8. PMID 2990962 DOI: 10.1016/0014-2999(85)90653-3  0.88
1985 Dawbarn D, De Quidt ME, Emson PC. Survival of basal ganglia neuropeptide Y-somatostatin neurones in Huntington's disease. Brain Research. 340: 251-60. PMID 2862959 DOI: 10.1016/0006-8993(85)90921-7  0.88
1985 Isacson O, Brundin P, Dawbarn D. Striatal grafts in the ibotenic acid-lesioned striatum Fernstrom Foundation Series. 539-549.  0.88
1984 Dawbarn D, Hunt SP, Emson PC. Neuropeptide Y: regional distribution chromatographic characterization and immunohistochemical demonstration in post-mortem human brain. Brain Research. 296: 168-73. PMID 6201235 DOI: 10.1016/0006-8993(84)90526-2  0.88
1982 Pycock C, Dawbarn D, O'Shaughnessy C. Behavioural and biochemical changes following chronic administration of L-dopa to rats. European Journal of Pharmacology. 79: 201-15. PMID 7201400 DOI: 10.1016/0014-2999(82)90626-4  0.88
1982 Dawbarn D, Pycock CJ. Lesions of the superior colliculus in the rat differentiate between nigrostriatal and mesolimbic dopamine systems. Brain Research. 235: 148-55. PMID 6892367 DOI: 10.1016/0006-8993(82)90205-0  0.88
1982 Dawbarn D, Pycock CJ. Forebrain dopamine systems following lesion of the superior colliculus in the rat Journal of Physiology. 76P.  0.88
1981 Barlow RB, Dawbarn D, Pycock CJ. A comparison of stereospecificity at central and peripheral 'muscarine-sensitive' acetylcholine receptors: observations with the enantiomeric forms of procyclidine and tricyclamol. British Journal of Pharmacology. 72: 277-80. PMID 7214097  0.88
1981 Dawbarn D, Harmar AJ, Pycock CJ. Intranigral injection of capsaicin enhances motor activity and depletes nigral 5-hydroxytryptamine but not substance P. Neuropharmacology. 20: 341-6. PMID 6170024 DOI: 10.1016/0028-3908(81)90006-X  0.88
1981 Dawbarn D, Pycock CJ. Motor effects following application of putative excitatory amino acid antagonists to the region of the mesencephalic dopamine cell bodies in the rat. Naunyn-Schmiedeberg's Archives of Pharmacology. 318: 100-4. PMID 6120471 DOI: 10.1007/BF00508833  0.88
1981 Dawbarn D, Long SK, Pycock CJ. Increased central 5-hydroxytryptamine receptor mechanisms in rats after chronic neuroleptic treatment. British Journal of Pharmacology. 73: 149-56. PMID 6116511  0.88
1981 Pycock CJ, Dawbarn D, Kerwin RW. Roles of GABA and glycine in the substantia nigra. Advances in Biochemical Psychopharmacology. 29: 77-87. PMID 6114627  0.88
1981 Dawbarn D, Pycock C. Differential sensitivity to neuroleptic drugs of cerebral dopamine receptors following chronic treatment of rats with trifluoperazine. European Journal of Pharmacology. 71: 233-45. PMID 6113967 DOI: 10.1016/0014-2999(81)90026-1  0.88
1981 Dawbarn D, Pycock CJ. Behavioural effects evoked by microinjection of excitatory amino acid antagonists into the midbrain of the rat British Journal of Pharmacology. 74: 235P-236P.  0.88
1981 Dawbarn D, Pycock CJ. Chronic administration (6 months) of L-DOPA to rats: Behavioral and neurochemical studies British Journal of Pharmacology. 74: 903P-904P.  0.88
1981 Dawbarn D, Harmar AJ, Pycock CJ. Behavioural and biochemical studies following injection of capsaicin into the substantia nigra of the rat British Journal of Pharmacology. 72: 493P.  0.88
1981 Dawbarn D, Long SK, Pycock CJ. Differential dopamine receptor supersensitivity after chronic phenothiazine treatment in rats British Journal of Pharmacology. 73: 240P-241P.  0.88
1980 Pycock CJ, Dawbarn D. Acute motor effects of N-methyl-D-aspartic acid and kainic acid applied focally to mesencephalic dopamine cell body regions in the rat. Neuroscience Letters. 18: 85-90. PMID 6763165 DOI: 10.1016/0304-3940(80)90217-7  0.88
1980 Dawbarn D, Pycock CJ. Potencies of different types of neuroleptic drugs in rats treated chronically with trifluperazine Neuroscience Letters. 19: S100.  0.88
1980 Dawbarn D, Pycock CJ. Motor responses evoked by N-methyl-D-aspartic acid and kainic acid from substantia nigra and ventral tegmental area in the rat British Journal of Pharmacology. 70: 54p-55p.  0.88
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