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Julie G. Ledford, Ph.D. - Publications

Affiliations: 
2006 University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Genetics, Molecular Biology
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52 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Iannuzo N, Welfley H, Li NC, Johnson MDL, Rojas-Quintero J, Polverino F, Guerra S, Li X, Cusanovich DA, Langlais PR, Ledford JG. CC16 drives VLA-2-dependent SPLUNC1 expression. Frontiers in Immunology. 14: 1277582. PMID 38053993 DOI: 10.3389/fimmu.2023.1277582  0.392
2023 Iannuzo N, Dy ABC, Guerra S, Langlais PR, Ledford JG. The Impact of CC16 on Pulmonary Epithelial-Driven Host Responses during Infection in Mouse Tracheal Epithelial Cells. Cells. 12. PMID 37566063 DOI: 10.3390/cells12151984  0.382
2023 Voraphani N, Stern DA, Ledford JG, Spangenberg AL, Zhai J, Wright AL, Morgan WJ, Kraft M, Sherrill DL, Curtin JA, Murray CS, Custovic A, Kull I, Hallberg J, Bergström A, et al. Circulating CC16 and Asthma: A Population-Based, Multi-Cohort Study from Early Childhood Through Adult Life. American Journal of Respiratory and Critical Care Medicine. PMID 37523710 DOI: 10.1164/rccm.202301-0041OC  0.341
2022 Pederson WP, Ellerman LM, Sandoval EC, Boitano S, Frye JB, Doyle KP, Brooks HL, Polverino F, Ledford JG. Development of a Novel Mouse Model of Menopause-associated Asthma. American Journal of Respiratory Cell and Molecular Biology. 67: 605-609. PMID 36318015 DOI: 10.1165/rcmb.2022-0181LE  0.663
2022 Li X, Guerra S, Ledford JG, Kraft M, Li H, Hastie AT, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston B, Israel E, Jarjour NN, Levy BD, Mauger DT, et al. Low CC16 mRNA Expression Levels in Bronchial Epithelial Cells Are Associated with Asthma Severity. American Journal of Respiratory and Critical Care Medicine. PMID 36066606 DOI: 10.1164/rccm.202206-1230OC  0.346
2022 Francisco D, Wang Y, Marshall C, Conway M, Addison KJ, Billheimer D, Kimura H, Numata M, Chu HW, Voelker DR, Kraft M, Ledford JG. Small Peptide Derivatives Within the Carbohydrate Recognition Domain of SP-A2 Modulate Asthma Outcomes in Mouse Models and Human Cells. Frontiers in Immunology. 13: 900022. PMID 35874703 DOI: 10.3389/fimmu.2022.900022  0.351
2022 Schiff HV, Rivas CM, Pederson WP, Sandoval E, Gillman S, Prisco J, Kume M, Dussor G, Vagner J, Ledford JG, Price TJ, DeFea KA, Boitano S. β-arrestin-biased proteinase-activated receptor-2 antagonist C781 limits allergen-induced airway hyperresponsiveness and inflammation. British Journal of Pharmacology. PMID 35735078 DOI: 10.1111/bph.15903  0.677
2021 Dy ABC, Langlais PR, Barker NK, Addison KJ, Tanyaratsrisakul S, Boitano S, Christenson SA, Kraft M, Meyers D, Bleecker ER, Li X, Ledford JG. Myeloid-associated differentiation marker is a novel SP-A-associated transmembrane protein whose expression on airway epithelial cells correlates with asthma severity. Scientific Reports. 11: 23392. PMID 34862427 DOI: 10.1038/s41598-021-02869-w  0.38
2021 Iannuzo N, Insel M, Marshall C, Pederson WP, Addison KJ, Polverino F, Guerra S, Ledford JG. CC16 deficiency in the context of early life infection results in augmented airway responses in adult mice. Infection and Immunity. IAI0054821. PMID 34780280 DOI: 10.1128/IAI.00548-21  0.731
2021 Collins KL, Younis US, Tanyaratsrisakul S, Polt R, Hay M, Mansour HM, Ledford JG. Angiotensin-(1-7) Peptide Hormone Reduces Inflammation and Pathogen Burden during Infection in Mice. Pharmaceutics. 13. PMID 34683907 DOI: 10.3390/pharmaceutics13101614  0.404
2021 Pederson WP, Cyphert-Daly JM, Tighe RM, Que LG, Ledford JG. Genetic variation in surfactant protein-A2 alters responses to ozone. Plos One. 16: e0247504. PMID 33617569 DOI: 10.1371/journal.pone.0247504  0.664
2020 Johnson MD, Younis US, Menghani SV, Addison KJ, Whalen M, Pilon AL, Cress AE, Polverino F, Romanoski C, Kraft M, Martinez FD, Guerra S, Ledford JG. CC16 Binding to α4β1 Integrin (VLA-4) Protects Against Infection. American Journal of Respiratory and Critical Care Medicine. PMID 33326355 DOI: 10.1164/rccm.202006-2576OC  0.355
2020 Younis US, Chu HW, Kraft M, Ledford JG. A 20-mer peptide derived from the lectin domain of decreases TNF-α production during infection. Infection and Immunity. PMID 32513852 DOI: 10.1128/Iai.00099-20  0.403
2020 Francisco D, Wang Y, Conway M, Hurbon AN, Dy ABC, Addison KJ, Chu HW, Voelker DR, Ledford JG, Kraft M. Surfactant Protein-A Protects against IL-13-Induced Inflammation in Asthma. Journal of Immunology (Baltimore, Md. : 1950). PMID 32245819 DOI: 10.4049/Jimmunol.1901227  0.459
2019 Takezaki A, Tsukumo SI, Setoguchi Y, Ledford JG, Goto H, Hosomichi K, Uehara H, Nishioka Y, Yasutomo K. A homozygous SFTPA1 mutation drives necroptosis of type II alveolar epithelial cells in patients with idiopathic pulmonary fibrosis. The Journal of Experimental Medicine. PMID 31601679 DOI: 10.1084/Jem.20182351  0.416
2019 Dy ABC, Arif MZ, Addison KJ, Que LG, Boitano S, Kraft M, Ledford JG. Genetic Variation in Surfactant Protein-A2 Delays Resolution of Eosinophilia in Asthma. Journal of Immunology (Baltimore, Md. : 1950). PMID 31350355 DOI: 10.4049/Jimmunol.1900546  0.399
2019 Younis US, Vallorz E, Addison KJ, Ledford JG, Myrdal PB. Preformulation and Evaluation of Tofacitinib as a Therapeutic Treatment for Asthma. Aaps Pharmscitech. 20: 167. PMID 30993508 DOI: 10.1208/S12249-019-1377-0  0.355
2019 Dakhama A, Al Mubarak R, Pavelka N, Voelker D, Seibold M, Ledford JG, Kraft M, Li L, Chu HW. Tollip Inhibits ST2 Signaling in Airway Epithelial Cells Exposed to Type 2 Cytokines and Rhinovirus. Journal of Innate Immunity. 1-13. PMID 30928973 DOI: 10.1159/000497072  0.331
2019 Dy A, Barker N, Langlais P, Ledford J. Late Breaking Abstract - Identification and functional testing of a novel receptor for SP-A on eosinophils European Respiratory Journal. 54. DOI: 10.1183/13993003.Congress-2019.Pa4093  0.381
2018 Zhai J, Insel M, Addison KJ, Stern DA, Pederson W, Dy A, Rojas-Quintero J, Owen CA, Sherrill DL, Morgan W, Wright AL, Halonen M, Martinez F, Kraft M, Guerra S, ... Ledford JG, et al. Club Cell Secretory Protein Deficiency Leads to Altered Lung Function. American Journal of Respiratory and Critical Care Medicine. PMID 30543455 DOI: 10.1164/Rccm.201807-1345Oc  0.66
2018 Dy ABC, Tanyaratsrisakul S, Voelker DR, Ledford JG. The Emerging Roles of Surfactant Protein-A in Asthma. Journal of Clinical & Cellular Immunology. 9. PMID 30123671 DOI: 10.4172/2155-9899.1000553  0.482
2018 Ito Y, Schaefer N, Sanchez A, Francisco D, Alam R, Martin RJ, Ledford JG, Stevenson C, Jiang D, Li L, Kraft M, Chu HW. Toll-Interacting Protein, Tollip, Inhibits IL-13-Mediated Pulmonary Eosinophilic Inflammation in Mice. Journal of Innate Immunity. PMID 29393212 DOI: 10.1159/000485850  0.377
2018 Kummarapurugu AB, Zheng S, Ledford J, Karandashova S, Voynow JA. High-Mobility Group Box 1 Upregulates MUC5AC and MUC5B Expression in Primary Airway Epithelial Cells. American Journal of Respiratory Cell and Molecular Biology. 58: 126-128. PMID 29286856 DOI: 10.1165/Rcmb.2017-0250Le  0.333
2018 Kraft M, Ledford J, Gozdz J, Li X, Francisco D, Manne A, Guerra S, Martinez F, Kaminski N, Wenzel S, Meyers D, Bleecker E. Club Cell Protein-16 modifies airway inflammation in asthma and is associated with significant clinical asthma outcomes European Respiratory Journal. DOI: 10.1183/13993003.Congress-2018.Pa5496  0.413
2018 Ledford J, Guerra S, Martinez F, Kraft M. Club cell secretory protein: a key mediator in Mycoplasma pneumoniae infection. European Respiratory Journal. DOI: 10.1183/13993003.Congress-2018.Pa4972  0.421
2017 Noutsios GT, Willis AL, Ledford JG, Chang EH. Novel role of surfactant protein A in bacterial sinusitis. International Forum of Allergy & Rhinology. PMID 28727907 DOI: 10.1002/Alr.21985  0.402
2017 Lugogo N, Francisco D, Addison KJ, Manne A, Pederson W, Ingram JL, Green CL, Suratt BT, Lee JJ, Sunday ME, Kraft M, Ledford JG. Obese Asthmatics Have Decreased Surfactant Protein-A Levels: Mechanisms and Implications. The Journal of Allergy and Clinical Immunology. PMID 28624607 DOI: 10.1016/J.Jaci.2017.05.028  0.698
2017 Ledford J, Lugogo N, Addison K, Francisco D, Kraft M. Impaired Tissue Eosinophil Resolution in Obese Asthma May Be Due to Surfactant Protein-A Insufficiency Journal of Allergy and Clinical Immunology. 139: AB267. DOI: 10.1016/J.Jaci.2016.12.860  0.355
2017 Noutsios GT, Romero E, Willis AL, Calton JT, Ledford JG, Chang EH. Expression Of Surfactant Protein A In Human Nasal Epithelial Cells After Infection With Rhinovirus C In The Presence of Histamine Journal of Allergy and Clinical Immunology. 139: AB64. DOI: 10.1016/J.Jaci.2016.12.255  0.385
2016 Stein MM, Hrusch CL, Gozdz J, Igartua C, Pivniouk V, Murray SE, Ledford JG, Marques Dos Santos M, Anderson RL, Metwali N, Neilson JW, Maier RM, Gilbert JA, Holbreich M, Thorne PS, et al. Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children. The New England Journal of Medicine. 375: 411-21. PMID 27518660 DOI: 10.1056/Nejmoa1508749  0.389
2016 Huang C, Jiang D, Francisco D, Berman R, Wu Q, Ledford JG, Moore CM, Ito Y, Stevenson C, Munson D, Li L, Kraft M, Chu HW. Tollip SNP rs5743899 Modulates Human Airway Epithelial Responses to Rhinovirus Infection. Clinical and Experimental Allergy : Journal of the British Society For Allergy and Clinical Immunology. PMID 27513438 DOI: 10.1111/Cea.12793  0.4
2016 Ledford JG, Addison KJ, Francisco D, Foster MW, Voelker DR, Que LG, Kraft M. Genetic Variation in Surfactant Protein-A2 Results in Altered Regulation of Eosinophil Activities and Enhanced Eosinophilia in Patients with Asthma. Annals of the American Thoracic Society. 13: S101. PMID 27027938 DOI: 10.1513/Annalsats.201508-520Mg  0.367
2015 Hsia BJ, Ledford JG, Potts-Kant EN, Nikam VS, Lugogo NL, Foster WM, Kraft M, Abraham SN, Wright JR. Correction notice for TNF-R on mast cells regulate airway responses to Mycoplasma pneumoniae. The Journal of Allergy and Clinical Immunology. PMID 26611673 DOI: 10.1016/J.Jaci.2015.09.049  0.742
2015 Ledford JG, Goto H, Potts EN, Degan S, Wei Chu H, Voelker DR, Sunday ME, Cianciolo GJ, Foster WM, Kraft M, Wright JR. Correction: SP-A Preserves Airway Homeostasis during Mycoplasma pneumoniae Infection in Mice. Journal of Immunology (Baltimore, Md. : 1950). 195: 2917-8. PMID 26342104 DOI: 10.4049/Jimmunol.1501597  0.594
2015 Ledford JG, Voelker DR, Addison KJ, Wang Y, Nikam VS, Degan S, Kandasamy P, Tanyaratsrisakul S, Fischer BM, Kraft M, Hollingsworth JW. Genetic Variation in SP-A2 Leads to Differential Binding to Mycoplasma pneumoniae Membranes and Regulation of Host Responses. Journal of Immunology (Baltimore, Md. : 1950). 194: 6123-32. PMID 25957169 DOI: 10.4049/Jimmunol.1500104  0.458
2014 Ogawa H, Ledford JG, Mukherjee S, Aono Y, Nishioka Y, Lee JJ, Izumi K, Hollingsworth JW. Surfactant protein D attenuates sub-epithelial fibrosis in allergic airways disease through TGF-β. Respiratory Research. 15: 143. PMID 25472740 DOI: 10.1186/S12931-014-0143-9  0.429
2014 Foster MW, Thompson JW, Ledford JG, Dubois LG, Hollingsworth JW, Francisco D, Tanyaratsrisakul S, Voelker DR, Kraft M, Moseley MA, Foster WM. Identification and Quantitation of Coding Variants and Isoforms of Pulmonary Surfactant Protein A. Journal of Proteome Research. 13: 3722-32. PMID 25025725 DOI: 10.1021/Pr500307F  0.387
2014 Ledford JG, Addison KJ, Foster MW, Que LG. Eosinophil-associated lung diseases. A cry for surfactant proteins A and D help? American Journal of Respiratory Cell and Molecular Biology. 51: 604-14. PMID 24960334 DOI: 10.1165/Rcmb.2014-0095Tr  0.424
2014 Holmer SM, Evans KS, Asfaw YG, Saini D, Schell WA, Ledford JG, Frothingham R, Wright JR, Sempowski GD, Perfect JR. Impact of surfactant protein D, interleukin-5, and eosinophilia on Cryptococcosis. Infection and Immunity. 82: 683-93. PMID 24478083 DOI: 10.1128/Iai.00855-13  0.631
2013 Mitsuhashi A, Goto H, Kuramoto T, Tabata S, Yukishige S, Abe S, Hanibuchi M, Kakiuchi S, Saijo A, Aono Y, Uehara H, Yano S, Ledford JG, Sone S, Nishioka Y. Surfactant protein A suppresses lung cancer progression by regulating the polarization of tumor-associated macrophages. The American Journal of Pathology. 182: 1843-53. PMID 23499372 DOI: 10.1016/J.Ajpath.2013.01.030  0.448
2013 Li Z, Tighe RM, Feng F, Ledford JG, Hollingsworth JW. Genes of innate immunity and the biological response to inhaled ozone. Journal of Biochemical and Molecular Toxicology. 27: 3-16. PMID 23169704 DOI: 10.1002/Jbt.21453  0.366
2012 Hsia BJ, Ledford JG, Potts-Kant EN, Nikam VS, Lugogo NL, Foster WM, Kraft M, Abraham SN, Wright JR. Mast cell TNF receptors regulate responses to Mycoplasma pneumoniae in surfactant protein A (SP-A)-/- mice. The Journal of Allergy and Clinical Immunology. 130: 205-14.e2. PMID 22502799 DOI: 10.1016/J.Jaci.2012.03.002  0.782
2012 Ledford JG, Mukherjee S, Kislan MM, Nugent JL, Hollingsworth JW, Wright JR. Surfactant protein-A suppresses eosinophil-mediated killing of Mycoplasma pneumoniae in allergic lungs. Plos One. 7: e32436. PMID 22384248 DOI: 10.1371/Journal.Pone.0032436  0.719
2012 Ledford JG, Kovarova M, Jania LA, Nguyen M, Koller BH. ONZIN deficiency attenuates contact hypersensitivity responses in mice. Immunology and Cell Biology. 90: 733-42. PMID 22249203 DOI: 10.1038/Icb.2011.107  0.556
2012 Mukherjee S, Giamberardino C, Thomas J, Evans K, Goto H, Ledford JG, Hsia B, Pastva AM, Wright JR. Surfactant protein A integrates activation signal strength to differentially modulate T cell proliferation. Journal of Immunology (Baltimore, Md. : 1950). 188: 957-67. PMID 22219327 DOI: 10.4049/Jimmunol.1100461  0.744
2012 Aono Y, Ledford JG, Mukherjee S, Ogawa H, Nishioka Y, Sone S, Beers MF, Noble PW, Wright JR. Surfactant protein-D regulates effector cell function and fibrotic lung remodeling in response to bleomycin injury. American Journal of Respiratory and Critical Care Medicine. 185: 525-36. PMID 22198976 DOI: 10.1164/Rccm.201103-0561Oc  0.651
2010 Ledford JG, Lo B, Kislan MM, Thomas JM, Evans K, Cain DW, Kraft M, Williams KL, Wright JR. Surfactant protein-A inhibits mycoplasma-induced dendritic cell maturation through regulation of HMGB-1 cytokine activity. Journal of Immunology (Baltimore, Md. : 1950). 185: 3884-94. PMID 20810986 DOI: 10.4049/Jimmunol.1000387  0.778
2010 Ledford JG, Pastva AM, Wright JR. Review: Collectins link innate and adaptive immunity in allergic airway disease. Innate Immunity. 16: 183-90. PMID 20418258 DOI: 10.1177/1753425910368446  0.694
2010 Goto H, Ledford JG, Mukherjee S, Noble PW, Williams KL, Wright JR. The role of surfactant protein A in bleomycin-induced acute lung injury. American Journal of Respiratory and Critical Care Medicine. 181: 1336-44. PMID 20167853 DOI: 10.1164/Rccm.200907-1002Oc  0.634
2009 Ledford JG, Goto H, Potts EN, Degan S, Chu HW, Voelker DR, Sunday ME, Cianciolo GJ, Foster WM, Kraft M, Wright JR. SP-A preserves airway homeostasis during Mycoplasma pneumoniae infection in mice. Journal of Immunology (Baltimore, Md. : 1950). 182: 7818-27. PMID 19494306 DOI: 10.4049/Jimmunol.0900452  0.696
2007 Ledford JG, Kovarova M, Koller BH. Impaired host defense in mice lacking ONZIN. Journal of Immunology (Baltimore, Md. : 1950). 178: 5132-43. PMID 17404296 DOI: 10.4049/Jimmunol.178.8.5132  0.631
2006 Allen IC, Pace AJ, Jania LA, Ledford JG, Latour AM, Snouwaert JN, Bernier V, Stocco R, Therien AG, Koller BH. Expression and function of NPSR1/GPRA in the lung before and after induction of asthma-like disease. American Journal of Physiology. Lung Cellular and Molecular Physiology. 291: L1005-17. PMID 16829631 DOI: 10.1152/Ajplung.00174.2006  0.802
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