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Steven E. Hyman, M.D. - Publications

Affiliations: 
Harvard University, Cambridge, MA, United States 
Website:
http://www.provost.harvard.edu/people/

65 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2010 Nestler EJ, Hyman SE. Animal models of neuropsychiatric disorders. Nature Neuroscience. 13: 1161-9. PMID 20877280 DOI: 10.1038/Nn.2647  0.428
2008 Hyman SE. How might cocaine interfere with brain development? Plos Medicine. 5: e130. PMID 18547140 DOI: 10.1371/Journal.Pmed.0050130  0.326
2008 Paletzki RF, Myakishev MV, Polesskaya O, Orosz A, Hyman SE, Vinson C. Inhibiting activator protein-1 activity alters cocaine-induced gene expression and potentiates sensitization. Neuroscience. 152: 1040-53. PMID 18355967 DOI: 10.1016/J.Neuroscience.2008.01.045  0.391
2006 Hyman SE, Malenka RC, Nestler EJ. Neural mechanisms of addiction: the role of reward-related learning and memory. Annual Review of Neuroscience. 29: 565-98. PMID 16776597 DOI: 10.1146/Annurev.Neuro.29.051605.113009  0.47
2006 Hyman SE. Even chromatin gets the blues. Nature Neuroscience. 9: 465-6. PMID 16568101 DOI: 10.1038/Nn0406-465  0.302
2006 Sgambato-Faure V, Xiong Y, Berke JD, Hyman SE, Strehler EE. The Homer-1 protein Ania-3 interacts with the plasma membrane calcium pump. Biochemical and Biophysical Research Communications. 343: 630-7. PMID 16554037 DOI: 10.1016/J.Bbrc.2006.03.020  0.565
2005 Voulalas PJ, Holtzclaw L, Wolstenholme J, Russell JT, Hyman SE. Metabotropic glutamate receptors and dopamine receptors cooperate to enhance extracellular signal-regulated kinase phosphorylation in striatal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 3763-73. PMID 15829628 DOI: 10.1523/Jneurosci.4574-04.2005  0.325
2004 Montague PR, Hyman SE, Cohen JD. Computational roles for dopamine in behavioural control. Nature. 431: 760-7. PMID 15483596 DOI: 10.1038/Nature03015  0.301
2003 Sgambato V, Minassian R, Nairn AC, Hyman SE. Regulation of ania-6 splice variants by distinct signaling pathways in striatal neurons. Journal of Neurochemistry. 86: 153-64. PMID 12807435 DOI: 10.1046/J.1471-4159.2003.01816.X  0.395
2001 Berke JD, Sgambato V, Zhu PP, Lavoie B, Vincent M, Krause M, Hyman SE. Dopamine and glutamate induce distinct striatal splice forms of Ania-6, an RNA polymerase II-associated cyclin. Neuron. 32: 277-87. PMID 11683997 DOI: 10.1016/S0896-6273(01)00465-2  0.61
2001 Kosofsky BE, Hyman SE. No time for complacency: the fetal brain on drugs. The Journal of Comparative Neurology. 435: 259-62. PMID 11406809 DOI: 10.1002/Cne.1027  0.557
2000 Hyman SE. Genes, gene expression, and behavior. Neurobiology of Disease. 7: 528-32. PMID 11042069 DOI: 10.1006/Nbdi.2000.0347  0.306
2000 Hyman SE. The genetics of mental illness: implications for practice. Bulletin of the World Health Organization. 78: 455-63. PMID 10885164 DOI: 10.1590/S0042-96862000000400007  0.322
2000 Berke JD, Hyman SE. Addiction, dopamine, and the molecular mechanisms of memory. Neuron. 25: 515-32. PMID 10774721 DOI: 10.1016/S0896-6273(00)81056-9  0.553
1999 Hyman SE. Selective gene expression increases behavioral sensitivity to cocaine. Nature Neuroscience. 2: 855-6. PMID 10491599 DOI: 10.1038/13147  0.342
1999 Kobierski LA, Wong AE, Srivastava S, Borsook D, Hyman SE. Cyclic AMP-dependent activation of the proenkephalin gene requires phosphorylation of CREB at serine-133 and a Src-related kinase. Journal of Neurochemistry. 73: 129-38. PMID 10386963 DOI: 10.1046/J.1471-4159.1999.0730129.X  0.339
1999 Schwarzschild MA, Cole RL, Meyers MA, Hyman SE. Contrasting calcium dependencies of SAPK and ERK activations by glutamate in cultured striatal neurons. Journal of Neurochemistry. 72: 2248-55. PMID 10349832 DOI: 10.1046/J.1471-4159.1999.0722248.X  0.309
1999 Van Koughnet K, Smirnova O, Hyman SE, Borsook D. Proenkephalin transgene regulation in the paraventricular nucleus of the hypothalamus by lipopolysaccharide and interleukin-1beta. The Journal of Comparative Neurology. 405: 199-215. PMID 10023810 DOI: 10.1002/(Sici)1096-9861(19990308)405:2<199::Aid-Cne5>3.0.Co;2-W  0.306
1998 Genova LM, Hyman SE. 5-HT3 receptor activation is required for induction of striatal c-Fos and phosphorylation of ATF-1 by amphetamine. Synapse (New York, N.Y.). 30: 71-8. PMID 9704883 DOI: 10.1002/(Sici)1098-2396(199809)30:1<71::Aid-Syn9>3.0.Co;2-H  0.345
1998 Fienberg AA, Hiroi N, Mermelstein PG, Song W, Snyder GL, Nishi A, Cheramy A, O'Callaghan JP, Miller DB, Cole DG, Corbett R, Haile CN, Cooper DC, Onn SP, Grace AA, ... ... Hyman SE, et al. DARPP-32: regulator of the efficacy of dopaminergic neurotransmission. Science (New York, N.Y.). 281: 838-42. PMID 9694658 DOI: 10.1126/Science.281.5378.838  0.506
1998 Berke JD, Paletzki RF, Aronson GJ, Hyman SE, Gerfen CR. A complex program of striatal gene expression induced by dopaminergic stimulation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 5301-10. PMID 9651213 DOI: 10.1523/Jneurosci.18-14-05301.1998  0.639
1998 Berke JD, Paletzki RF, Aronson GJ, Hyman SE, Gerfen CR. A Complex Program of Striatal Gene Expression Induced by Dopaminergic Stimulation The Journal of Neuroscience. 18: 5301-5310. DOI: 10.1523/JNEUROSCI.18-14-05301.1998  0.548
1997 Genova L, Berke J, Hyman SE. Molecular adaptations to psychostimulants in striatal neurons: toward a pathophysiology of addiction. Neurobiology of Disease. 4: 239-46. PMID 9361300 DOI: 10.1006/Nbdi.1997.0154  0.572
1997 Breiter HC, Gollub RL, Weisskoff RM, Kennedy DN, Makris N, Berke JD, Goodman JM, Kantor HL, Gastfriend DR, Riorden JP, Mathew RT, Rosen BR, Hyman SE. Acute effects of cocaine on human brain activity and emotion. Neuron. 19: 591-611. PMID 9331351 DOI: 10.1016/S0896-6273(00)80374-8  0.576
1997 Schwarzschild MA, Cole RL, Hyman SE. Glutamate, but not dopamine, stimulates stress-activated protein kinase and AP-1-mediated transcription in striatal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 3455-66. PMID 9133371 DOI: 10.1523/Jneurosci.17-10-03455.1997  0.379
1997 Hyman S, Schwarzschild M, Cole R. Glutamate, but not dopamine stimulates AP-1 mediated transcription in striatal neurons Biological Psychiatry. 42: 149S-150S. DOI: 10.1016/S0006-3223(97)87503-8  0.332
1996 Berhow MT, Hiroi N, Kobierski LA, Hyman SE, Nestler EJ. Influence of cocaine on the JAK-STAT pathway in the mesolimbic dopamine system. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 8019-26. PMID 8987828 DOI: 10.1523/Jneurosci.16-24-08019.1996  0.514
1996 Konradi C, Leveque JC, Hyman SE. Amphetamine and dopamine-induced immediate early gene expression in striatal neurons depends on postsynaptic NMDA receptors and calcium. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 4231-9. PMID 8753884 DOI: 10.1523/Jneurosci.16-13-04231.1996  0.645
1996 Hyman SE. Shaking out the cause of addiction. Science (New York, N.Y.). 273: 611-2. PMID 8701316 DOI: 10.1126/Science.273.5275.611  0.314
1996 Hyman SE. Addiction to cocaine and amphetamine. Neuron. 16: 901-4. PMID 8630246 DOI: 10.1016/S0896-6273(00)80111-7  0.393
1996 Hyman SE, Nestler EJ. Initiation and adaptation: a paradigm for understanding psychotropic drug action. The American Journal of Psychiatry. 153: 151-62. PMID 8561194 DOI: 10.1176/Ajp.153.2.151  0.478
1996 Breiter H, Berke J, Kennedy W, Rosen B, Hyman S. Activation of striatum and amygdala during reward conditioning: An FMRI study Neuroimage. 3: S220. DOI: 10.1016/S1053-8119(96)80222-9  0.55
1995 Kosofsky BE, Genova LM, Hyman SE. Postnatal age defines specificity of immediate early gene induction by cocaine in developing rat brain. The Journal of Comparative Neurology. 351: 27-40. PMID 7896938 DOI: 10.1002/Cne.903510104  0.644
1995 Cole RL, Konradi C, Douglass J, Hyman SE. Neuronal adaptation to amphetamine and dopamine: molecular mechanisms of prodynorphin gene regulation in rat striatum. Neuron. 14: 813-23. PMID 7718243 DOI: 10.1016/0896-6273(95)90225-2  0.664
1995 Konradi C, Cole RL, Green D, Senatus P, Leveque JC, Pollack AE, Grossbard SJ, Hyman SE. Analysis of the proenkephalin second messenger-inducible enhancer in rat striatal cultures. Journal of Neurochemistry. 65: 1007-15. PMID 7643080 DOI: 10.1046/J.1471-4159.1995.65031007.X  0.629
1995 Hyman SE, Cole RL, Konradi C, Kosofsky BE. Dopamine regulation of transcription factor-target interactions in rat striatum. Chemical Senses. 20: 257-60. PMID 7583020 DOI: 10.1093/Chemse/20.2.257  0.747
1995 Borsook D, Hyman SE. Proenkephalin gene regulation in the neuroendocrine hypothalamus: a model of gene regulation in the CNS. The American Journal of Physiology. 269: E393-408. PMID 7573416 DOI: 10.1152/Ajpendo.1995.269.3.E393  0.356
1995 Kosofsky BE, Genova LM, Hyman SE. Substance P phenotype defines specificity of c-fos induction by cocaine in developing rat striatum. The Journal of Comparative Neurology. 351: 41-50. PMID 7534774 DOI: 10.1002/Cne.903510105  0.637
1994 Borsook D, Konradi C, Falkowski O, Comb M, Hyman SE. Molecular mechanisms of stress-induced proenkephalin gene regulation: CREB interacts with the proenkephalin gene in the mouse hypothalamus and is phosphorylated in response to hyperosmolar stress. Molecular Endocrinology (Baltimore, Md.). 8: 240-8. PMID 8170480 DOI: 10.1210/Mend.8.2.8170480  0.636
1994 Borsook D, Falkowski O, Burstein R, Strassman A, Konradi C, Dauber A, Comb M, Hyman SE. Stress-induced regulation of a human proenkephalin-beta-galactosidase fusion gene in the hypothalamus of transgenic mice. Molecular Endocrinology (Baltimore, Md.). 8: 116-25. PMID 8152426 DOI: 10.1210/Mend.8.1.8152426  0.605
1994 Konradi C, Cole RL, Heckers S, Hyman SE. Amphetamine regulates gene expression in rat striatum via transcription factor CREB. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 5623-34. PMID 8083758 DOI: 10.1523/Jneurosci.14-09-05623.1994  0.676
1994 Borsook D, Falkowski O, Rosen H, Comb M, Hyman SE. Opioids modulate stress-induced proenkephalin gene expression in the hypothalamus of transgenic mice: a model of endogenous opioid gene regulation by exogenous opioids. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 7261-71. PMID 7996174 DOI: 10.1016/0167-0115(94)90373-5  0.333
1994 Cole DG, Kobierski LA, Konradi C, Hyman SE. 6-Hydroxydopamine lesions of rat substantia nigra up-regulate dopamine-induced phosphorylation of the cAMP-response element-binding protein in striatal neurons. Proceedings of the National Academy of Sciences of the United States of America. 91: 9631-5. PMID 7937819 DOI: 10.1073/Pnas.91.20.9631  0.631
1994 Hyman SE, Konradi C, Kobierski L, Cole R, Senatus P, Green D. Pharmacologic regulation of striatal proenkephalin gene expression via transcription factor CREB. Progress in Clinical and Biological Research. 390: 155-71. PMID 7724644  0.602
1994 Symes A, Lewis S, Corpus L, Rajan P, Hyman SE, Fink JS. STAT proteins participate in the regulation of the vasoactive intestinal peptide gene by the ciliary neurotrophic factor family of cytokines. Molecular Endocrinology (Baltimore, Md.). 8: 1750-63. PMID 7708062 DOI: 10.1210/Mend.8.12.7708062  0.584
1994 Schwarzschild MA, Dauer WT, Lewis SE, Hamill LK, Fink JS, Hyman SE. Leukemia inhibitory factor and ciliary neurotrophic factor increase activated Ras in a neuroblastoma cell line and in sympathetic neuron cultures. Journal of Neurochemistry. 63: 1246-54. PMID 7523587 DOI: 10.1046/J.1471-4159.1994.63041246.X  0.548
1994 Lewis SE, Rao MS, Symes AJ, Dauer WT, Fink JS, Landis SC, Hyman SE. Coordinate regulation of choline acetyltransferase, tyrosine hydroxylase, and neuropeptide mRNAs by ciliary neurotrophic factor and leukemia inhibitory factor in cultured sympathetic neurons. Journal of Neurochemistry. 63: 429-38. PMID 7518494 DOI: 10.1046/J.1471-4159.1994.63020429.X  0.561
1994 Hyman SE, Konradi C, Cole RL. Regulation of striatal proenkephalin and prodynorphin gene expression by transcription factor CREB Regulatory Peptides. 54: 127-128. DOI: 10.1016/0167-0115(94)90422-7  0.633
1993 Hyman SE. New insights into how antipsychotic drugs might work. Harvard Review of Psychiatry. 1: 68-9. PMID 9384831 DOI: 10.3109/10673229309017060  0.305
1993 Konradi C, Kobierski LA, Nguyen TV, Heckers S, Hyman SE. The cAMP-response-element-binding protein interacts, but Fos protein does not interact, with the proenkephalin enhancer in rat striatum. Proceedings of the National Academy of Sciences of the United States of America. 90: 7005-9. PMID 8346209 DOI: 10.1073/Pnas.90.15.7005  0.635
1993 Hyman SE, Kosofsky BE, Nguyen TV, Cohen BM, Comb MJ. Everything activates c-fos--how can it matter? Nida Research Monograph. 125: 25-38. PMID 8341366  0.597
1993 Kosofsky BE, Hyman SE. The ontogeny of immediate early gene response to cocaine: a molecular analysis of the effects of cocaine on developing rat brain. Nida Research Monograph. 125: 161-71. PMID 8341363  0.567
1993 Symes AJ, Rao MS, Lewis SE, Landis SC, Hyman SE, Fink JS. Ciliary neurotrophic factor coordinately activates transcription of neuropeptide genes in a neuroblastoma cell line. Proceedings of the National Academy of Sciences of the United States of America. 90: 572-6. PMID 8093644 DOI: 10.1073/Pnas.90.2.572  0.587
1992 Hope B, Kosofsky B, Hyman SE, Nestler EJ. Regulation of immediate early gene expression and AP-1 binding in the rat nucleus accumbens by chronic cocaine. Proceedings of the National Academy of Sciences of the United States of America. 89: 5764-8. PMID 1631058 DOI: 10.1073/Pnas.89.13.5764  0.735
1992 Comb MJ, Kobierski L, Chu HM, Tan Y, Borsook D, Herrup K, Hyman SE. Regulation of opioid gene expression: a model to understand neural plasticity. Nida Research Monograph. 126: 98-112. PMID 1491720  0.302
1992 Borsook D, Rosen H, Collard M, Dressler H, Herrup K, Comb MJ, Hyman SE. Expression and regulation of a proenkephalin beta-galactosidase fusion gene in the reproductive system of transgenic mice. Molecular Endocrinology (Baltimore, Md.). 6: 1502-12. PMID 1435791 DOI: 10.1210/Mend.6.9.1435791  0.31
1992 Nguyen TV, Kosofsky BE, Birnbaum R, Cohen BM, Hyman SE. Differential expression of c-fos and zif268 in rat striatum after haloperidol, clozapine, and amphetamine. Proceedings of the National Academy of Sciences of the United States of America. 89: 4270-4. PMID 1374894 DOI: 10.1073/Pnas.89.10.4270  0.645
1990 Ross ME, Evinger MJ, Hyman SE, Carroll JM, Mucke L, Comb M, Reis DJ, Joh TH, Goodman HM. Identification of a functional glucocorticoid response element in the phenylethanolamine N-methyltransferase promoter using fusion genes introduced into chromaffin cells in primary culture. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 10: 520-30. PMID 2303857 DOI: 10.1523/Jneurosci.10-02-00520.1990  0.525
1990 Van Nguyen T, Kobierski L, Comb M, Hyman SE. The effect of depolarization on expression of the human proenkephalin gene is synergistic with cAMP and dependent upon a cAMP-inducible enhancer. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 10: 2825-33. PMID 2167356 DOI: 10.1523/Jneurosci.10-08-02825.1990  0.355
1989 Hyman SE, Comb M, Pearlberg J, Goodman HM. An AP-2 element acts synergistically with the cyclic AMP- and phorbol ester-inducible enhancer of the human proenkephalin gene. Molecular and Cellular Biology. 9: 321-4. PMID 2538722 DOI: 10.1128/Mcb.9.1.321  0.508
1988 Hyman SE, Comb M, Lin YS, Pearlberg J, Green MR, Goodman HM. A common trans-acting factor is involved in transcriptional regulation of neurotransmitter genes by cyclic AMP. Molecular and Cellular Biology. 8: 4225-33. PMID 2903436 DOI: 10.1128/Mcb.8.10.4225  0.548
1988 Comb M, Mermod N, Hyman SE, Pearlberg J, Ross ME, Goodman HM. Proteins bound at adjacent DNA elements act synergistically to regulate human proenkephalin cAMP inducible transcription. The Embo Journal. 7: 3793-805. PMID 2850173 DOI: 10.1002/J.1460-2075.1988.Tb03264.X  0.518
1988 Hyman SE. Recent developments in neurobiology: Part I. Synaptic transmission. Psychosomatics. 29: 157-65. PMID 2453072 DOI: 10.1016/S0033-3182(88)72392-0  0.317
1987 Schalling M, Dagerlind A, Brene S, Petterson R, Kvist S, Brownstein M, Hyman SE, Mucke L, Goodman HM, Joh TH. Localization of mRNA for phenylethanolamine N-methyltransferase (PNMT) using in situ hybridization. Acta Physiologica Scandinavica. 131: 631-2. PMID 3442246 DOI: 10.1111/J.1748-1716.1987.Tb08288.X  0.428
1987 Comb M, Hyman SE, Goodman HM. Mechanisms of trans-synaptic regulation of gene expression Trends in Neurosciences. 10: 473-478. DOI: 10.1016/0166-2236(87)90103-2  0.546
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