Andy N. Mead - Publications

Affiliations: 
Pfizer Ltd, UK, Sandwich, England, United Kingdom 
Area:
Drug addiction

34/56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Jenkinson S, Goody SMG, Bassyouni A, Jones R, Otto-Bruc A, Duquennoy S, DaSilva JK, Butler P, Mead A. Translation of in vitro cannabinoid 1 receptor agonist activity to in vivo pharmacodynamic endpoints. Journal of Pharmacological and Toxicological Methods. 106899. PMID 32702414 DOI: 10.1016/J.Vascn.2020.106899  0.347
2016 Wager TT, Chappie TA, Horton D, Chandrasekaran RY, Samas BM, Dunn-Sims E, Hsu C, Nawreen N, Vanase-Frawley MA, O'Connor RE, Schmidt C, Dlugolenski K, Stratman NC, Majchrzak MJ, Kormos BL, ... ... Mead AN, et al. Dopamine D3/D2 Receptor Antagonist PF-4363467 Attenuates Opioid Drug-Seeking Behavior without Concomitant D2 Side Effects. Acs Chemical Neuroscience. PMID 27715007 DOI: 10.1021/Acschemneuro.6B00297  0.363
2014 Mead AN. Appropriate experimental approaches for predicting abuse potential and addictive qualities in preclinical drug discovery. Expert Opinion On Drug Discovery. 9: 1281-91. PMID 25176123 DOI: 10.1517/17460441.2014.956077  0.323
2013 Horton DB, Potter DM, Mead AN. A translational pharmacology approach to understanding the predictive value of abuse potential assessments. Behavioural Pharmacology. 24: 410-36. PMID 23873088 DOI: 10.1097/Fbp.0B013E3283644D2E  0.314
2011 O'Connor EC, Chapman K, Butler P, Mead AN. The predictive validity of the rat self-administration model for abuse liability. Neuroscience and Biobehavioral Reviews. 35: 912-38. PMID 21036191 DOI: 10.1016/J.Neubiorev.2010.10.012  0.311
2011 Tyszkiewicz CM, Mead A. Drug-induced anxiety and the elevated plus maze: Effect of lighting conditions Journal of Pharmacological and Toxicological Methods. 64: e24. DOI: 10.1016/J.Vascn.2011.03.087  0.34
2010 O'Connor EC, Mead AN. Tramadol acts as a weak reinforcer in the rat self-administration model, consistent with its low abuse liability in humans. Pharmacology, Biochemistry, and Behavior. 96: 279-86. PMID 20580909 DOI: 10.1016/J.Pbb.2010.05.018  0.364
2010 O'Connor EC, Crombag HS, Mead AN, Stephens DN. The mGluR5 antagonist MTEP dissociates the acquisition of predictive and incentive motivational properties of reward-paired stimuli in mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 1807-17. PMID 20375996 DOI: 10.1038/Npp.2010.48  0.751
2010 O'Connor EC, Parker D, Rollema H, Mead AN. The alpha4beta2 nicotinic acetylcholine-receptor partial agonist varenicline inhibits both nicotine self-administration following repeated dosing and reinstatement of nicotine seeking in rats. Psychopharmacology. 208: 365-76. PMID 19967529 DOI: 10.1007/S00213-009-1739-5  0.309
2010 O’Connor EC, Crombag H, Mead A, Engblom D, Stephens D. Incentive learning and the psychomotor activating effects of cocaine are controlled by mGluR5 in dopaminoceptive neurons F1000research. 1. DOI: 10.7490/F1000Research.734.1  0.647
2007 Mead AN, Zamanillo D, Becker N, Stephens DN. AMPA-receptor GluR1 subunits are involved in the control over behavior by cocaine-paired cues. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 343-53. PMID 16495937 DOI: 10.1038/Sj.Npp.1301045  0.689
2007 Boshoff EL, Staveley SM, Mead AN, Butler P. THE USE OF THE RAT DRUG DISCRIMINATION PARADIGM IN ASSESSMENT OF ABUSE LIABILITY Journal of Pharmacological and Toxicological Methods. 56: e48. DOI: 10.1016/J.Vascn.2007.02.097  0.314
2006 Mead AN, Morris HV, Dixon CI, Rulten SL, Mayne LV, Zamanillo D, Stephens DN. AMPA receptor GluR2, but not GluR1, subunit deletion impairs emotional response conditioning in mice. Behavioral Neuroscience. 120: 241-8. PMID 16719688 DOI: 10.1037/0735-7044.120.2.241  0.747
2005 Mead AN, Brown G, Le Merrer J, Stephens DN. Effects of deletion of gria1 or gria2 genes encoding glutamatergic AMPA-receptor subunits on place preference conditioning in mice. Psychopharmacology. 179: 164-71. PMID 15619119 DOI: 10.1007/S00213-004-2071-8  0.719
2005 Stephens D, Mead A. S6 EXPLORING THE ROLE OF AMPA RECEPTOR SUBUNITS IN ADDICTIVE PROCESSES USING MICE WITH TARGETED DELETIONS OF GLUR1 AND GLUR2 SUBUNITS Behavioural Pharmacology. 16: S2. DOI: 10.1097/00008877-200509001-00006  0.614
2004 Stephens DN, Mead AN. Behavioural plasticity-induced changes in drug response. Commentary on Badiani and Robinson drug-induced neurobehavioral plasticity: the role of environmental context. Behavioural Pharmacology. 15: 377-80. PMID 15343063 DOI: 10.1097/00008877-200409000-00011  0.6
2004 Mead AN, Crombag HS, Rocha BA. Sensitization of psychomotor stimulation and conditioned reward in mice: differential modulation by contextual learning. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 249-58. PMID 12942147 DOI: 10.1038/Sj.Npp.1300294  0.709
2003 Mead AN, Stephens DN. Involvement of AMPA receptor GluR2 subunits in stimulus-reward learning: evidence from glutamate receptor gria2 knock-out mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 9500-7. PMID 14573529 DOI: 10.1523/Jneurosci.23-29-09500.2003  0.72
2003 Stephens DN, Mead AN. What role do GluR1 subunits play in drug abuse? Trends in Neurosciences. 26: 181-2; author reply . PMID 12689767 DOI: 10.1016/S0166-2236(03)00080-8  0.609
2003 Mead AN, Stephens DN. Selective disruption of stimulus-reward learning in glutamate receptor gria1 knock-out mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 1041-8. PMID 12574434 DOI: 10.1523/Jneurosci.23-03-01041.2003  0.709
2002 Rocha BA, Goulding EH, O'Dell LE, Mead AN, Coufal NG, Parsons LH, Tecott LH. Enhanced locomotor, reinforcing, and neurochemical effects of cocaine in serotonin 5-hydroxytryptamine 2C receptor mutant mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 10039-45. PMID 12427861 DOI: 10.1523/Jneurosci.22-22-10039.2002  0.442
2002 Stephens DN, Mead AN, Ripley TL. Studying the neurobiology of stimulant and alcohol abuse and dependence in genetically manipulated mice. Behavioural Pharmacology. 13: 327-45. PMID 12394407 DOI: 10.1097/00008877-200209000-00004  0.602
2002 Rocha BA, Mead AN, Kosofsky BE. Increased vulnerability to self-administer cocaine in mice prenatally exposed to cocaine. Psychopharmacology. 163: 221-9. PMID 12202969 DOI: 10.1007/S00213-002-1140-0  0.424
2002 Mead AN, Rocha BA, Donovan DM, Katz JL. Intravenous cocaine induced-activity and behavioural sensitization in norepinephrine-, but not dopamine-transporter knockout mice. The European Journal of Neuroscience. 16: 514-20. PMID 12193195 DOI: 10.1046/J.1460-9568.2002.02104.X  0.429
2002 Highfield DA, Mead AN, Grimm JW, Rocha BA, Shaham Y. Reinstatement of cocaine seeking in 129X1/SvJ mice: effects of cocaine priming, cocaine cues and food deprivation. Psychopharmacology. 161: 417-24. PMID 12073170 DOI: 10.1007/S00213-002-1047-9  0.42
2002 Mead AN, Katz JL, Rocha BA. Intravenous cocaine-induced activity in A/J and C57BL/6J mice: behavioral sensitization and conditioned activity. Neuropharmacology. 42: 976-86. PMID 12069908 DOI: 10.1016/S0028-3908(02)00048-5  0.466
2001 Bronsert MR, Mead AN, Hen R, Rocha BA. Amphetamine-induced locomotor activation in 5-HT(1B) knockout mice: effects of injection route on acute and sensitized responses. Behavioural Pharmacology. 12: 549-55. PMID 11795245  0.302
2000 Jackson A, Mead AN, Stephens DN. Behavioural effects of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate-receptor antagonists and their relevance to substance abuse. Pharmacology & Therapeutics. 88: 59-76. PMID 11033384 DOI: 10.1016/S0163-7258(00)00078-4  0.659
2000 Dunworth SJ, Mead AN, Stephens DN. Previous experience of withdrawal from chronic diazepam ameliorates the aversiveness of precipitated withdrawal and reduces withdrawal-induced c-fos expression in nucleus accumbens. The European Journal of Neuroscience. 12: 1501-8. PMID 10762378 DOI: 10.1046/J.1460-9568.2000.00036.X  0.643
1999 Mead AN, Vasilaki A, Spyraki C, Duka T, Stephens DN. AMPA-receptor involvement in c-fos expression in the medial prefrontal cortex and amygdala dissociates neural substrates of conditioned activity and conditioned reward. The European Journal of Neuroscience. 11: 4089-98. PMID 10583497 DOI: 10.1046/J.1460-9568.1999.00828.X  0.657
1999 Mead AN, Stephens DN. CNQX but not NBQX prevents expression of amphetamine-induced place preference conditioning: a role for the glycine site of the NMDA receptor, but not AMPA receptors. The Journal of Pharmacology and Experimental Therapeutics. 290: 9-15. PMID 10381753  0.623
1998 Mead AN, Stephens DN. AMPA-receptors are involved in the expression of amphetamine-induced behavioural sensitisation, but not in the expression of amphetamine-induced conditioned activity in mice. Neuropharmacology. 37: 1131-8. PMID 9833643 DOI: 10.1016/S0028-3908(98)00101-4  0.699
1998 Jackson A, Mead AN, Rocha BA, Stephens DN. AMPA receptors and motivation for drug: effect of the selective antagonist NBQX on behavioural sensitization and on self-administration in mice. Behavioural Pharmacology. 9: 457-67. PMID 9832931 DOI: 10.1097/00008877-199809000-00009  0.691
1998 Mead AN, Stephens DN. THE ROLE OF AMPA RECEPTORS IN CONDITIONED REINFORCEMENT Behavioural Pharmacology. 9: S61. DOI: 10.1097/00008877-199808000-00133  0.622
Low-probability matches (unlikely to be authored by this person)
2014 Wager TT, Chandrasekaran RY, Bradley J, Rubitski D, Berke H, Mente S, Butler T, Doran A, Chang C, Fisher K, Knafels J, Liu S, Ohren J, Marconi M, DeMarco G, ... ... Mead A, et al. Casein kinase 1δ/ε inhibitor PF-5006739 attenuates opioid drug-seeking behavior. Acs Chemical Neuroscience. 5: 1253-65. PMID 25299732 DOI: 10.1021/Cn500201X  0.297
2011 Tyszkiewicz CM, Cannon KE, Mead A. Optimizing learned helplessness testing conditions to detect changes in behavioral despair Journal of Pharmacological and Toxicological Methods. 64: e21-e22. DOI: 10.1016/J.Vascn.2011.03.078  0.292
2017 Nickolls SA, Gurrell R, van Amerongen G, Kammonen J, Cao L, Brown AR, Stead C, Mead A, Watson C, Hsu C, Owen RM, Pike A, Fish RL, Chen L, Qiu R, et al. Pharmacology in translation; the preclinical and early clinical profile of the novel α2/3 functionally selective GABAA receptor positive allosteric modulator PF-06372865. British Journal of Pharmacology. PMID 29214652 DOI: 10.1111/Bph.14119  0.289
2013 Rosado A, Mead A, DaSilva J. Establishing the EEG Sleep Profile of Cocaine Withdrawal in Sprague–Dawley rats Journal of Pharmacological and Toxicological Methods. 68: e8. DOI: 10.1016/J.Vascn.2013.01.039  0.289
2007 O'Connor EC, Mead AN, Staveley SM, Pertinez H, Butler P. THE RAT SELF-ADMINISTRATION MODEL AND DETERMINING THE ABUSE POTENTIAL OF NEW CHEMICAL ENTITIES — A FOCUS ON CNS STIMULANTS Journal of Pharmacological and Toxicological Methods. 56: e39. DOI: 10.1016/J.Vascn.2007.02.079  0.278
2013 Nawreen N, Tyszkiewicz C, Roberts D, Parker D, Mead A. Self administration of “weak” reinforcers in the rat Journal of Pharmacological and Toxicological Methods. 68: e8. DOI: 10.1016/J.Vascn.2013.01.037  0.263
2008 Staveley SM, O'Connor E, Parker D, Broad A, Mead A. Validation of rat behavioural models for the assessment of cannabinoid abuse potential Journal of Pharmacological and Toxicological Methods. 58: 167-167. DOI: 10.1016/J.Vascn.2008.05.087  0.259
2014 Ewart L, Aylott M, Deurinck M, Engwall M, Gallacher DJ, Geys H, Jarvis P, Ju H, Leishman D, Leong L, McMahon N, Mead A, Milliken P, Suter W, Teisman A, et al. The concordance between nonclinical and phase I clinical cardiovascular assessment from a cross-company data sharing initiative. Toxicological Sciences : An Official Journal of the Society of Toxicology. 142: 427-35. PMID 25246669 DOI: 10.1093/Toxsci/Kfu198  0.253
2013 Hsu C, Newman R, Shires S, Tse K, Warr A, Mead A, Waldron G. Use of the beam walking and drug discrimination models for determining intrinsic efficacy and selectivity of subtype selective GABA-A ligands in rodents Journal of Pharmacological and Toxicological Methods. 68: e8. DOI: 10.1016/J.Vascn.2013.01.038  0.25
2016 Mead AN, Amouzadeh HR, Chapman K, Ewart L, Giarola A, Jackson SJ, Jarvis P, Jordaan P, Redfern W, Traebert M, Valentin JP, Vargas HM. The predictive value of the rodent neurofunctional assessment for commonly reported adverse events in Phase I clinical trials. Regulatory Toxicology and Pharmacology : Rtp. PMID 27155597 DOI: 10.1016/J.Yrtph.2016.05.002  0.234
2010 Coles DI, Broad A, Mead A. Characterisation of pentobarbital physical dependence and withdrawal in rats Journal of Pharmacological and Toxicological Methods. 62: e9. DOI: 10.1016/J.Vascn.2010.11.029  0.229
2013 Ewart L, Amouzadeh H, Aylott M, Chapman K, Jordaan P, Leishman D, Locher K, Mead A, Murphy D, Scathcard J, Valentin J. Analysis of concordance of nonclinical rodent respiratory function measurements to phase i trial outcome using the animal model framework Journal of Pharmacological and Toxicological Methods. 68: e42-e43. DOI: 10.1016/J.Vascn.2013.01.154  0.204
2011 Newman RJ, Chime S, Waldron G, Mead A. Evaluation of contextual renewal as a nonclinical model for cognitive deficits Journal of Pharmacological and Toxicological Methods. 64: e24-e25. DOI: 10.1016/J.Vascn.2011.03.088  0.196
2015 Horton DB, Dunn-Sims E, Wager TT, Chang C, Doran A, Rosado A, Mead AN. Casein kinase-1 inhibitors as a novel treatment for substance use disorders Drug and Alcohol Dependence. 156: e98. DOI: 10.1016/J.Drugalcdep.2015.07.1184  0.196
2011 Tyszkiewicz CM, Cannon KE, Mead A. Short-term social isolation: A possible rodent model for a depressive-like state? Journal of Pharmacological and Toxicological Methods. 64: e21. DOI: 10.1016/J.Vascn.2011.03.077  0.188
2008 Bilsland JG, Wheeldon A, Mead A, Znamenskiy P, Almond S, Waters KA, Thakur M, Beaumont V, Bonnert TP, Heavens R, Whiting P, McAllister G, Munoz-Sanjuan I. Behavioral and neurochemical alterations in mice deficient in anaplastic lymphoma kinase suggest therapeutic potential for psychiatric indications. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 685-700. PMID 17487225 DOI: 10.1038/Sj.Npp.1301446  0.161
2017 Komen J, Gustafsson F, Basak J, Leonard E, Harding J, Mead A, Anderton M. Development of rat pancreatic acinar cell model for the assessment of drug induced injury caused by MCL1 inhibition Toxicology Letters. 280: S264-S265. DOI: 10.1016/J.TOXLET.2017.07.937  0.109
2023 Poulter S, Austin N, Armstrong R, Barnes M, Bucknell SJ, Higueruelo A, Banerjee J, Mead A, Mould R, MacSweeney C, O'Brien MA, Stott LA, Watson SP. The Identification of GPR52 Agonist HTL0041178, a Potential Therapy for Schizophrenia and Related Psychiatric Disorders. Acs Medicinal Chemistry Letters. 14: 499-505. PMID 37077397 DOI: 10.1021/acsmedchemlett.3c00052  0.072
2016 Kozyak BW, Mead A, Song Y, Morales L, Kornegay J, Stedman HH. 383. Clinico-Pathological Correlation in the Earliest Stages of Muscular Dystrophy Suggests Sensitive Physiological Parameters as Novel Primary Endpoints for Systemic Gene Therapy Molecular Therapy. 24: S153. DOI: 10.1016/S1525-0016(16)33192-6  0.033
2016 Mead A, Malik A, Krishnankutty R, Stedman HH. 389. Muscular Dystrophy Genes and the Early Metazoan Transition from Dynein- to Myosin-Powered Locomotion Molecular Therapy. 24: S154. DOI: 10.1016/S1525-0016(16)33198-7  0.011
2016 Song Y, Mead A, Petrov M, Ingraham P, Morales L, Rosenblum S, Kornegay J, Stedman HH. 388. Hypersensitivity of MYH16 Fibers (M Fibers) to Myodegeneration in Canine Muscular Dystrophy Molecular Therapy. 24: S154. DOI: 10.1016/S1525-0016(16)33197-5  0.01
1991 Mead A. Memories Draw Generations Back to Lynch Appalachian Heritage. 19: 20-22. DOI: 10.1353/APH.1991.0052  0.01
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