Gregg E. Homanics - Publications

University of Pittsburgh, Pittsburgh, PA, United States 
Transgenic mice

175 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Plasil SL, Collins VJ, Baratta AM, Farris SP, Homanics GE. Hippocampal ceRNA networks from chronic intermittent ethanol vapor-exposed male mice and functional analysis of top-ranked lncRNA genes for ethanol drinking phenotypes. Advances in Drug and Alcohol Research. 2. PMID 36908580 DOI: 10.3389/adar.2022.10831  0.327
2021 Hawkins NA, Nomura T, Duarte S, Barse L, Williams RW, Homanics GE, Mulligan MK, Contractor A, Kearney JA. Gabra2 is a genetic modifier of Dravet syndrome in mice. Mammalian Genome : Official Journal of the International Mammalian Genome Society. PMID 34086081 DOI: 10.1007/s00335-021-09877-1  0.351
2021 Baratta AM, Rathod RS, Plasil SL, Seth A, Homanics GE. Exposure to drugs of abuse induce effects that persist across generations. International Review of Neurobiology. 156: 217-277. PMID 33461664 DOI: 10.1016/bs.irn.2020.08.003  0.756
2020 Plasil SL, Seth A, Homanics GE. CRISPR Turbo Accelerated KnockOut (CRISPy TAKO) for Rapid Screening of Gene Function. Frontiers in Genome Editing. 2. PMID 33604589 DOI: 10.3389/fgeed.2020.598522  0.307
2020 Zamudio PA, Gioia DA, Lopez M, Homanics GE, Woodward JJ. The escalation in ethanol consumption following chronic intermittent ethanol exposure is blunted in mice expressing ethanol-resistant GluN1 or GluN2A NMDA receptor subunits. Psychopharmacology. PMID 33052417 DOI: 10.1007/s00213-020-05680-z  0.377
2020 Rathod RS, Ferguson C, Seth A, Baratta AM, Plasil SL, Homanics GE. Effects of Paternal Preconception Vapor Alcohol Exposure Paradigms on Behavioral Responses in Offspring. Brain Sciences. 10. PMID 32971974 DOI: 10.3390/brainsci10090658  0.805
2020 Saba LM, Hoffman PL, Homanics GE, Mahaffey S, Daulatabad SV, Janga SC, Tabakoff B. A Long Non-Coding RNA (Lrap) Modulates Brain Gene Expression and Levels of Alcohol Consumption in Rats. Genes, Brain, and Behavior. PMID 32893479 DOI: 10.1111/Gbb.12698  0.312
2020 Rompala GR, Ferguson C, Homanics GE. Coincubation of sperm with epididymal extracellular vesicle preparations from chronic intermittent ethanol-treated mice is sufficient to impart anxiety-like and ethanol-induced behaviors to adult progeny. Alcohol (Fayetteville, N.Y.). PMID 32445808 DOI: 10.1016/J.Alcohol.2020.05.001  0.792
2020 Gallegos S, San Martin L, Araya A, Lovinger DM, Homanics GE, Aguayo LG. Reduced sedation and increased ethanol consumption in knock-in mice expressing an ethanol insensitive alpha 2 subunit of the glycine receptor. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 32357359 DOI: 10.1038/S41386-020-0689-9  0.504
2019 Zamudio PA, Smothers CT, Homanics GE, Woodward JJ. Knock-in mice expressing an ethanol-resistant GluN2A NMDA receptor subunit show altered responses to ethanol. Alcoholism, Clinical and Experimental Research. PMID 31872888 DOI: 10.1111/Acer.14273  0.451
2019 Johnson KA, Liput DJ, Homanics GE, Lovinger DM. Age-dependent impairment of metabotropic glutamate receptor 2-dependent long-term depression in the mouse striatum by chronic ethanol exposure. Alcohol (Fayetteville, N.Y.). PMID 31233806 DOI: 10.1016/J.Alcohol.2019.06.003  0.422
2019 Mulligan MK, Abreo T, Neuner SM, Parks C, Watkins CE, Houseal MT, Shapaker TM, Hook M, Tan H, Wang X, Ingels J, Peng J, Lu L, Kaczorowski CC, Bryant CD, ... Homanics GE, et al. Identification of a Functional Non-coding Variant in the GABA Receptor α2 Subunit of the C57BL/6J Mouse Reference Genome: Major Implications for Neuroscience Research. Frontiers in Genetics. 10: 188. PMID 30984232 DOI: 10.3389/Fgene.2019.00188  0.421
2019 Rompala GR, Homanics GE. Intergenerational effects of alcohol: a review of paternal preconception ethanol exposure studies and epigenetic mechanisms in the male germline. Alcoholism, Clinical and Experimental Research. PMID 30908630 DOI: 10.1111/Acer.14029  0.767
2019 Muñoz B, Gallegos S, Peters C, Murath P, Lovinger DM, Homanics GE, Aguayo LG. Influence of nonsynaptic α1 glycine receptors on ethanol consumption and place preference. Addiction Biology. PMID 30884072 DOI: 10.1111/Adb.12726  0.509
2019 Beeler E, Nobile ZL, Homanics GE. Paternal Preconception Every-Other-Day Ethanol Drinking Alters Behavior and Ethanol Consumption in Offspring. Brain Sciences. 9. PMID 30845665 DOI: 10.3390/Brainsci9030056  0.394
2019 Blednov YA, Bajo M, Roberts AJ, Da Costa AJ, Black M, Edmunds S, Mayfield J, Roberto M, Homanics GE, Lasek AW, Hitzemann RJ, Harris RA. Scn4b regulates the hypnotic effects of ethanol and other sedative drugs. Genes, Brain, and Behavior. e12562. PMID 30817077 DOI: 10.1111/Gbb.12562  0.469
2018 Rompala GR, Simons A, Kihle B, Homanics GE. Paternal Preconception Chronic Variable Stress Confers Attenuated Ethanol Drinking Behavior Selectively to Male Offspring in a Pre-Stress Environment Dependent Manner. Frontiers in Behavioral Neuroscience. 12: 257. PMID 30450042 DOI: 10.3389/Fnbeh.2018.00257  0.778
2018 Rompala GR, Mounier A, Wolfe CM, Lin Q, Lefterov I, Homanics GE. Heavy Chronic Intermittent Ethanol Exposure Alters Small Noncoding RNAs in Mouse Sperm and Epididymosomes. Frontiers in Genetics. 9: 32. PMID 29472946 DOI: 10.3389/Fgene.2018.00032  0.768
2018 Zamudio-Bulcock PA, Homanics GE, Woodward JJ. Loss of Ethanol inhibition of NMDAR-mediated currents and plasticity of cerebellar synapses in mice expressing the GluN1(F639A) subunit. Alcoholism, Clinical and Experimental Research. PMID 29323417 DOI: 10.1111/Acer.13597  0.466
2018 Varodayan FP, Khom S, Patel RR, Steinman MQ, Hedges DM, Oleata CS, Homanics GE, Roberto M, Bajo M. Role of TLR4 in the Modulation of Central Amygdala GABA Transmission by CRF Following Restraint Stress. Alcohol and Alcoholism (Oxford, Oxfordshire). PMID 29309503 DOI: 10.1093/Alcalc/Agx114  0.31
2017 Hill SY, Rompala G, Homanics GE, Zezza N. Cross-generational effects of alcohol dependence in humans on HRAS and TP53 methylation in offspring. Epigenomics. PMID 28799801 DOI: 10.2217/Epi-2017-0052  0.744
2017 Blednov YA, Borghese CM, Ruiz CI, Cullins MA, Da Costa A, Osterndorff-Kahanek EA, Homanics GE, Harris RA. Mutation of the inhibitory ethanol site in GABAA ρ1 receptors promotes tolerance to ethanol-induced motor incoordination. Neuropharmacology. PMID 28623169 DOI: 10.1016/J.Neuropharm.2017.06.013  0.526
2017 Yocum GT, Turner DL, Danielsson J, Barajas MB, Zhang Y, Xu D, Harrison N, Homanics GE, Farber DL, Emala CW. GABAA Receptor α4 Subunit Knockout Enhances Lung Inflammation and Airway Reactivity in a Murine Asthma Model. American Journal of Physiology. Lung Cellular and Molecular Physiology. ajplung.00107.2017. PMID 28473323 DOI: 10.1152/Ajplung.00107.2017  0.382
2017 den Hartog CR, Gilstrap M, Eaton B, Lench DH, Mulholland PJ, Homanics GE, Woodward JJ. Effects of Repeated Ethanol Exposures on NMDA Receptor Expression and Locomotor Sensitization in Mice Expressing Ethanol Resistant NMDA Receptors. Frontiers in Neuroscience. 11: 84. PMID 28270746 DOI: 10.3389/Fnins.2017.00084  0.497
2017 Ji X, Saha S, Gao G, Lasek AW, Homanics GE, Guildford M, Tapper AR, Martin GE. The Sodium Channel β4 Auxiliary Subunit Selectively Controls Long-Term Depression in Core Nucleus Accumbens Medium Spiny Neurons. Frontiers in Cellular Neuroscience. 11: 17. PMID 28243192 DOI: 10.3389/Fncel.2017.00017  0.337
2016 Harris RA, Bajo M, Bell RL, Blednov YA, Varodayan FP, Truitt J, de Guglielmo G, Lasek AW, Logrip ML, Vendruscolo LF, Roberts AJ, Roberts E, George O, Mayfield J, Billiar TR, ... ... Homanics GE, et al. Genetic and pharmacologic manipulation of TLR4 has minimal impact on ethanol consumption in rodents. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 27986929 DOI: 10.1523/Jneurosci.2002-16.2016  0.439
2016 Rompala GR, Finegersh A, Slater M, Homanics GE. Paternal preconception alcohol exposure imparts intergenerational alcohol-related behaviors to male offspring on a pure C57BL/6J background. Alcohol (Fayetteville, N.Y.). PMID 27876231 DOI: 10.1016/J.Alcohol.2016.11.001  0.802
2016 Rompala GR, Finegersh A, Homanics GE. Paternal preconception ethanol exposure blunts hypothalamic-pituitary-adrenal axis responsivity and stress-induced excessive fluid intake in male mice. Alcohol (Fayetteville, N.Y.). 53: 19-25. PMID 27286933 DOI: 10.1016/J.Alcohol.2016.03.006  0.794
2016 Finegersh A, Homanics GE. Chromatin immunoprecipitation and gene expression analysis of neuronal subtypes after fluorescence activated cell sorting. Journal of Neuroscience Methods. PMID 26868730 DOI: 10.1016/J.Jneumeth.2016.02.006  0.682
2015 Cai X, Huang H, Kuzirian MS, Snyder LM, Matsushita M, Lee MC, Ferguson C, Homanics GE, Barth AL, Ross SE. Generation of a KOR-Cre knockin mouse strain to study cells involved in kappa opioid signaling. Genesis (New York, N.Y. : 2000). PMID 26575788 DOI: 10.1002/Dvg.22910  0.314
2015 Finegersh A, Ferguson C, Maxwell S, Mazariegos D, Farrell D, Homanics GE. Repeated vapor ethanol exposure induces transient histone modifications in the brain that are modified by genotype and brain region. Frontiers in Molecular Neuroscience. 8: 39. PMID 26300722 DOI: 10.3389/Fnmol.2015.00039  0.725
2015 Jaiswal MK, Keros S, Zhao M, Inan M, Schwartz TH, Anderson SA, Homanics GE, Goldstein PA. Reduction in focal ictal activity following transplantation of MGE interneurons requires expression of the GABAA receptor α4 subunit. Frontiers in Cellular Neuroscience. 9: 127. PMID 25914623 DOI: 10.3389/Fncel.2015.00127  0.376
2015 Finegersh A, Rompala GR, Martin DI, Homanics GE. Drinking beyond a lifetime: New and emerging insights into paternal alcohol exposure on subsequent generations. Alcohol (Fayetteville, N.Y.). 49: 461-70. PMID 25887183 DOI: 10.1016/J.Alcohol.2015.02.008  0.798
2015 Naito A, Muchhala KH, Trang J, Asatryan L, Trudell JR, Homanics GE, Alkana RL, Davies DL. Manipulations of extracellular Loop 2 in α1 GlyR ultra-sensitive ethanol receptors (USERs) enhance receptor sensitivity to isoflurane, ethanol, and lidocaine, but not propofol. Neuroscience. 297: 68-77. PMID 25827497 DOI: 10.1016/J.Neuroscience.2015.03.034  0.441
2014 Naito A, Muchhala KH, Asatryan L, Trudell JR, Homanics GE, Perkins DI, Davies DL, Alkana RL. Glycine and GABA(A) ultra-sensitive ethanol receptors as novel tools for alcohol and brain research. Molecular Pharmacology. 86: 635-46. PMID 25245406 DOI: 10.1124/Mol.114.093773  0.512
2014 Cramer JM, Zimmerman MW, Thompson T, Homanics GE, Lazo JS, Lagasse E. Deletion of Ptp4a3 reduces clonogenicity and tumor-initiation ability of colitis-associated cancer cells in mice. Stem Cell Research. 13: 164-71. PMID 24950307 DOI: 10.1016/J.Scr.2014.05.004  0.487
2014 Finegersh A, Homanics GE. Acute ethanol alters multiple histone modifications at model gene promoters in the cerebral cortex. Alcoholism, Clinical and Experimental Research. 38: 1865-73. PMID 24942484 DOI: 10.1111/Acer.12465  0.715
2014 Finegersh A, Homanics GE. Paternal alcohol exposure reduces alcohol drinking and increases behavioral sensitivity to alcohol selectively in male offspring. Plos One. 9: e99078. PMID 24896617 DOI: 10.1371/Journal.Pone.0099078  0.741
2014 Aguayo LG, Castro P, Mariqueo T, Muñoz B, Xiong W, Zhang L, Lovinger DM, Homanics GE. Altered sedative effects of ethanol in mice with α1 glycine receptor subunits that are insensitive to Gβγ modulation. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 2538-48. PMID 24801766 DOI: 10.1038/Npp.2014.100  0.518
2014 Mariqueo TA, Agurto A, Muñoz B, San Martin L, Coronado C, Fernández-Pérez EJ, Murath P, Sánchez A, Homanics GE, Aguayo LG. Effects of ethanol on glycinergic synaptic currents in mouse spinal cord neurons. Journal of Neurophysiology. 111: 1940-8. PMID 24572089 DOI: 10.1152/Jn.00789.2013  0.401
2014 Zimmerman MW, McQueeney KE, Isenberg JS, Pitt BR, Wasserloos KA, Homanics GE, Lazo JS. Protein-tyrosine phosphatase 4A3 (PTP4A3) promotes vascular endothelial growth factor signaling and enables endothelial cell motility. The Journal of Biological Chemistry. 289: 5904-13. PMID 24403062 DOI: 10.1074/Jbc.M113.480038  0.477
2014 Xiong W, Chen SR, He L, Cheng K, Zhao YL, Chen H, Li DP, Homanics GE, Peever J, Rice KC, Wu LG, Pan HL, Zhang L. Presynaptic glycine receptors as a potential therapeutic target for hyperekplexia disease. Nature Neuroscience. 17: 232-9. PMID 24390226 DOI: 10.1038/Nn.3615  0.355
2014 Peng Z, Zhang N, Chandra D, Homanics GE, Olsen RW, Houser CR. Altered localization of the δ subunit of the GABAA receptor in the thalamus of α4 subunit knockout mice. Neurochemical Research. 39: 1104-17. PMID 24352815 DOI: 10.1007/S11064-013-1202-1  0.38
2014 Iyer SV, Chandra D, Homanics GE. GABAA-R α4 subunits are required for the low dose locomotor stimulatory effect of alphaxalone, but not for several other behavioral responses to alphaxalone, etomidate or propofol. Neurochemical Research. 39: 1048-56. PMID 24062179 DOI: 10.1007/S11064-013-1148-3  0.596
2013 den Hartog CR, Beckley JT, Smothers TC, Lench DH, Holseberg ZL, Fedarovich H, Gilstrap MJ, Homanics GE, Woodward JJ. Alterations in ethanol-induced behaviors and consumption in knock-in mice expressing ethanol-resistant NMDA receptors. Plos One. 8: e80541. PMID 24244696 DOI: 10.1371/Journal.Pone.0080541  0.489
2013 Ferguson C, McKay M, Harris RA, Homanics GE. Toll-like receptor 4 (Tlr4) knockout rats produced by transcriptional activator-like effector nuclease (TALEN)-mediated gene inactivation. Alcohol (Fayetteville, N.Y.). 47: 595-9. PMID 24199847 DOI: 10.1016/J.Alcohol.2013.09.043  0.36
2013 Zimmerman MW, Homanics GE, Lazo JS. Targeted deletion of the metastasis-associated phosphatase Ptp4a3 (PRL-3) suppresses murine colon cancer. Plos One. 8: e58300. PMID 23555575 DOI: 10.1371/Journal.Pone.0058300  0.518
2013 Blednov YA, Benavidez JM, Black M, Chandra D, Homanics GE, Rudolph U, Harris RA. Linking GABA(A) receptor subunits to alcohol-induced conditioned taste aversion and recovery from acute alcohol intoxication. Neuropharmacology. 67: 46-56. PMID 23147414 DOI: 10.1016/J.Neuropharm.2012.10.016  0.841
2012 Borghese CM, Xiong W, Oh SI, Ho A, Mihic SJ, Zhang L, Lovinger DM, Homanics GE, Eger EI, Harris RA. Mutations M287L and Q266I in the glycine receptor α1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but not the minimal alveolar concentration in knockin mice. Anesthesiology. 117: 765-71. PMID 22885675 DOI: 10.1097/Aln.0B013E31826A0D93  0.449
2012 Sabaliauskas N, Shen H, Homanics GE, Smith SS, Aoki C. Knockout of the γ-aminobutyric acid receptor subunit α4 reduces functional δ-containing extrasynaptic receptors in hippocampal pyramidal cells at the onset of puberty. Brain Research. 1450: 11-23. PMID 22418059 DOI: 10.1016/J.Brainres.2012.02.035  0.477
2012 Blednov YA, Benavidez JM, Homanics GE, Harris RA. Behavioral characterization of knockin mice with mutations M287L and Q266I in the glycine receptor α1 subunit. The Journal of Pharmacology and Experimental Therapeutics. 340: 317-29. PMID 22037202 DOI: 10.1124/Jpet.111.185124  0.487
2012 Borghese CM, Blednov YA, Quan Y, Iyer SV, Xiong W, Mihic SJ, Zhang L, Lovinger DM, Trudell JR, Homanics GE, Harris RA. Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols. The Journal of Pharmacology and Experimental Therapeutics. 340: 304-16. PMID 22037201 DOI: 10.1124/Jpet.111.185116  0.684
2012 Zimmerman MW, Homanics GE, Lazo JS. Abstract 3258: Targeted-deletion of Ptp4a3 suppresses murine colon tumorigenesis Cancer Research. 72: 3258-3258. DOI: 10.1158/1538-7445.Am2012-3258  0.319
2012 Zimmerman M, Homanics G, Lazo J. 47 Targeting Ptp4a3 in Colon Tumorigenesis and Cancer Progression European Journal of Cancer. 48: 16. DOI: 10.1016/S0959-8049(12)71845-2  0.345
2011 Suryanarayanan A, Liang J, Meyer EM, Lindemeyer AK, Chandra D, Homanics GE, Sieghart W, Olsen RW, Spigelman I. Subunit Compensation and Plasticity of Synaptic GABA(A) Receptors Induced by Ethanol in α4 Subunit Knockout Mice. Frontiers in Neuroscience. 5: 110. PMID 21977012 DOI: 10.3389/Fnins.2011.00110  0.835
2011 Rau V, Oh I, Liao M, Bodarky C, Fanselow MS, Homanics GE, Sonner JM, Eger EI. Gamma-aminobutyric acid type A receptor β3 subunit forebrain-specific knockout mice are resistant to the amnestic effect of isoflurane. Anesthesia and Analgesia. 113: 500-4. PMID 21813630 DOI: 10.1213/Ane.0B013E3182273Aff  0.482
2011 Iyer SV, Benavides RA, Chandra D, Cook JM, Rallapalli S, June HL, Homanics GE. α4-Containing GABA(A) Receptors are Required for Antagonism of Ethanol-Induced Motor Incoordination and Hypnosis by the Imidazobenzodiazepine Ro15-4513. Frontiers in Pharmacology. 2: 18. PMID 21779248 DOI: 10.3389/Fphar.2011.00018  0.835
2011 Duveau V, Laustela S, Barth L, Gianolini F, Vogt KE, Keist R, Chandra D, Homanics GE, Rudolph U, Fritschy JM. Spatiotemporal specificity of GABAA receptor-mediated regulation of adult hippocampal neurogenesis. The European Journal of Neuroscience. 34: 362-73. PMID 21722213 DOI: 10.1111/J.1460-9568.2011.07782.X  0.801
2011 Chang KY, Park YG, Park HY, Homanics GE, Kim J, Kim D. Lack of CaV3.1 channels causes severe motor coordination defects and an age-dependent cerebellar atrophy in a genetic model of essential tremor. Biochemical and Biophysical Research Communications. 410: 19-23. PMID 21621520 DOI: 10.1016/J.Bbrc.2011.05.082  0.338
2011 Quesada A, Bui PH, Homanics GE, Hankinson O, Handforth A. Comparison of mibefradil and derivative NNC 55-0396 effects on behavior, cytochrome P450 activity, and tremor in mouse models of essential tremor. European Journal of Pharmacology. 659: 30-6. PMID 21256842 DOI: 10.1016/J.Ejphar.2011.01.004  0.35
2011 Harris RA, Osterndorff-Kahanek E, Ponomarev I, Homanics GE, Blednov YA. Testing the silence of mutations: Transcriptomic and behavioral studies of GABA(A) receptor α1 and α2 subunit knock-in mice. Neuroscience Letters. 488: 31-5. PMID 21056629 DOI: 10.1016/J.Neulet.2010.10.075  0.503
2011 Blednov YA, Borghese CM, McCracken ML, Benavidez JM, Geil CR, Osterndorff-Kahanek E, Werner DF, Iyer S, Swihart A, Harrison NL, Homanics GE, Harris RA. Loss of ethanol conditioned taste aversion and motor stimulation in knockin mice with ethanol-insensitive α2-containing GABA(A) receptors. The Journal of Pharmacology and Experimental Therapeutics. 336: 145-54. PMID 20876231 DOI: 10.1124/Jpet.110.171645  0.836
2011 Werner DF, Swihart A, Rau V, Jia F, Borghese CM, McCracken ML, Iyer S, Fanselow MS, Oh I, Sonner JM, Eger EI, Harrison NL, Harris RA, Homanics GE. Inhaled anesthetic responses of recombinant receptors and knockin mice harboring α2(S270H/L277A) GABA(A) receptor subunits that are resistant to isoflurane. The Journal of Pharmacology and Experimental Therapeutics. 336: 134-44. PMID 20807777 DOI: 10.1124/Jpet.110.170431  0.831
2010 Handforth A, Homanics GE, Covey DF, Krishnan K, Lee JY, Sakimura K, Martin FC, Quesada A. T-type calcium channel antagonists suppress tremor in two mouse models of essential tremor. Neuropharmacology. 59: 380-7. PMID 20547167 DOI: 10.1016/J.Neuropharm.2010.05.012  0.369
2010 Haselkorn ML, Shellington DK, Jackson EK, Vagni VA, Janesko-Feldman K, Dubey RK, Gillespie DG, Cheng D, Bell MJ, Jenkins LW, Homanics GE, Schnermann J, Kochanek PM. Adenosine A1 receptor activation as a brake on the microglial response after experimental traumatic brain injury in mice. Journal of Neurotrauma. 27: 901-10. PMID 20121416 DOI: 10.1089/Neu.2009.1075  0.341
2010 Wilking JA, Hesterberg KG, Crouch EL, Homanics GE, Stitzel JA. Chrna4 A529 knock-in mice exhibit altered nicotine sensitivity. Pharmacogenetics and Genomics. 20: 121-30. PMID 20061993 DOI: 10.1097/Fpc.0B013E3283369347  0.369
2010 Chandra D, Halonen LM, Linden AM, Procaccini C, Hellsten K, Homanics GE, Korpi ER. Prototypic GABA(A) receptor agonist muscimol acts preferentially through forebrain high-affinity binding sites. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 999-1007. PMID 20032968 DOI: 10.1038/Npp.2009.203  0.818
2010 Moore MD, Cushman J, Chandra D, Homanics GE, Olsen RW, Fanselow MS. Trace and contextual fear conditioning is enhanced in mice lacking the alpha4 subunit of the GABA(A) receptor. Neurobiology of Learning and Memory. 93: 383-7. PMID 20018248 DOI: 10.1016/J.Nlm.2009.12.004  0.824
2010 Blednov YA, Walker DL, Iyer SV, Homanics G, Harris AR. Mice lacking Gad2 show altered behavioral effects of ethanol, flurazepam and gabaxadol. Addiction Biology. 15: 45-61. PMID 20002022 DOI: 10.1111/J.1369-1600.2009.00186.X  0.727
2009 Rau V, Iyer SV, Oh I, Chandra D, Harrison N, Eger EI, Fanselow MS, Homanics GE, Sonner JM. Gamma-aminobutyric acid type A receptor alpha 4 subunit knockout mice are resistant to the amnestic effect of isoflurane. Anesthesia and Analgesia. 109: 1816-22. PMID 19923508 DOI: 10.1213/Ane.0B013E3181Bf6Ae6  0.844
2009 Wiltgen BJ, Godsil BP, Peng Z, Saab F, June HL, Linn ML, Cook JM, Houser CR, O'Dell TJ, Homanics GE, Fanselow MS. The alpha1 subunit of the GABA(A) receptor modulates fear learning and plasticity in the lateral amygdala. Frontiers in Behavioral Neuroscience. 3: 37. PMID 19876409 DOI: 10.3389/Neuro.08.037.2009  0.435
2009 Hentschke H, Benkwitz C, Banks MI, Perkins MG, Homanics GE, Pearce RA. Altered GABAA,slow inhibition and network oscillations in mice lacking the GABAA receptor beta3 subunit. Journal of Neurophysiology. 102: 3643-55. PMID 19846622 DOI: 10.1152/Jn.00651.2009  0.494
2009 Gong H, He J, Lee JH, Mallick E, Gao X, Li S, Homanics GE, Xie W. Activation of the liver X receptor prevents lipopolysaccharide-induced lung injury. The Journal of Biological Chemistry. 284: 30113-21. PMID 19717840 DOI: 10.1074/Jbc.M109.047753  0.324
2009 Skvorak KJ, Hager EJ, Arning E, Bottiglieri T, Paul HS, Strom SC, Homanics GE, Sun Q, Jansen EE, Jakobs C, Zinnanti WJ, Gibson KM. Hepatocyte transplantation (HTx) corrects selected neurometabolic abnormalities in murine intermediate maple syrup urine disease (iMSUD). Biochimica Et Biophysica Acta. 1792: 1004-10. PMID 19699299 DOI: 10.1016/J.Bbadis.2009.08.006  0.76
2009 Skvorak KJ, Paul HS, Dorko K, Marongiu F, Ellis E, Chace D, Ferguson C, Gibson KM, Homanics GE, Strom SC. Hepatocyte transplantation improves phenotype and extends survival in a murine model of intermediate maple syrup urine disease. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 1266-73. PMID 19436271 DOI: 10.1038/Mt.2009.99  0.74
2009 Halonen LM, Sinkkonen ST, Chandra D, Homanics GE, Korpi ER. Brain regional distribution of GABA(A) receptors exhibiting atypical GABA agonism: roles of receptor subunits. Neurochemistry International. 55: 389-96. PMID 19397945 DOI: 10.1016/J.Neuint.2009.04.008  0.821
2009 Berry RB, Chandra D, Diaz-Granados JL, Homanics GE, Matthews DB. Investigation of ethanol-induced impairment of spatial memory in gamma2 heterozygous knockout mice. Neuroscience Letters. 455: 84-7. PMID 19368851 DOI: 10.1016/J.Neulet.2009.03.046  0.824
2009 Herd MB, Foister N, Chandra D, Peden DR, Homanics GE, Brown VJ, Balfour DJ, Lambert JJ, Belelli D. Inhibition of thalamic excitability by 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-ol: a selective role for delta-GABA(A) receptors. The European Journal of Neuroscience. 29: 1177-87. PMID 19302153 DOI: 10.1111/J.1460-9568.2009.06680.X  0.824
2009 Zinnanti WJ, Lazovic J, Griffin K, Skvorak KJ, Paul HS, Homanics GE, Bewley MC, Cheng KC, Lanoue KF, Flanagan JM. Dual mechanism of brain injury and novel treatment strategy in maple syrup urine disease. Brain : a Journal of Neurology. 132: 903-18. PMID 19293241 DOI: 10.1093/Brain/Awp024  0.735
2009 Werner DF, Swihart AR, Ferguson C, Lariviere WR, Harrison NL, Homanics GE. Alcohol-induced tolerance and physical dependence in mice with ethanol insensitive alpha1 GABA A receptors. Alcoholism, Clinical and Experimental Research. 33: 289-99. PMID 19032579 DOI: 10.1111/J.1530-0277.2008.00832.X  0.84
2009 Ying SW, Werner DF, Homanics GE, Harrison NL, Goldstein PA. Isoflurane modulates excitability in the mouse thalamus via GABA-dependent and GABA-independent mechanisms. Neuropharmacology. 56: 438-47. PMID 18948126 DOI: 10.1016/J.Neuropharm.2008.09.015  0.697
2008 Berry RB, Werner DF, Wang X, Jablonski MM, Homanics GE, Mittleman G, Matthews DB. Mice with targeted genetic reduction of GABA(A) receptor alpha1 subunits display performance differences in Morris water maze tasks. Neurobiology of Learning and Memory. 90: 580-3. PMID 18625330 DOI: 10.1016/J.Nlm.2008.06.004  0.677
2008 Jia F, Chandra D, Homanics GE, Harrison NL. Ethanol modulates synaptic and extrasynaptic GABAA receptors in the thalamus. The Journal of Pharmacology and Experimental Therapeutics. 326: 475-82. PMID 18477766 DOI: 10.1124/Jpet.108.139303  0.828
2008 Jia F, Yue M, Chandra D, Keramidas A, Goldstein PA, Homanics GE, Harrison NL. Taurine is a potent activator of extrasynaptic GABA(A) receptors in the thalamus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 106-15. PMID 18171928 DOI: 10.1523/Jneurosci.3996-07.2008  0.808
2008 Jia F, Yue M, Chandra D, Homanics GE, Goldstein PA, Harrison NL. Isoflurane is a potent modulator of extrasynaptic GABA(A) receptors in the thalamus. The Journal of Pharmacology and Experimental Therapeutics. 324: 1127-35. PMID 18094320 DOI: 10.1124/Jpet.107.134569  0.822
2008 Herd MB, Haythornthwaite AR, Rosahl TW, Wafford KA, Homanics GE, Lambert JJ, Belelli D. The expression of GABAA beta subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells. The Journal of Physiology. 586: 989-1004. PMID 18079158 DOI: 10.1113/Jphysiol.2007.146746  0.456
2008 Chandra D, Werner DF, Liang J, Suryanarayanan A, Harrison NL, Spigelman I, Olsen RW, Homanics GE. Normal acute behavioral responses to moderate/high dose ethanol in GABAA receptor alpha 4 subunit knockout mice. Alcoholism, Clinical and Experimental Research. 32: 10-8. PMID 18076749 DOI: 10.1111/J.1530-0277.2007.00563.X  0.85
2008 Liang J, Suryanarayanan A, Chandra D, Homanics GE, Olsen RW, Spigelman I. Functional consequences of GABAA receptor alpha 4 subunit deletion on synaptic and extrasynaptic currents in mouse dentate granule cells. Alcoholism, Clinical and Experimental Research. 32: 19-26. PMID 18070250 DOI: 10.1111/J.1530-0277.2007.00564.X  0.831
2008 Peden DR, Petitjean CM, Herd MB, Durakoglugil MS, Rosahl TW, Wafford K, Homanics GE, Belelli D, Fritschy JM, Lambert JJ. Developmental maturation of synaptic and extrasynaptic GABAA receptors in mouse thalamic ventrobasal neurones. The Journal of Physiology. 586: 965-87. PMID 18063661 DOI: 10.1113/Jphysiol.2007.145375  0.498
2008 DeLorey TM, Sahbaie P, Hashemi E, Homanics GE, Clark JD. Gabrb3 gene deficient mice exhibit impaired social and exploratory behaviors, deficits in non-selective attention and hypoplasia of cerebellar vermal lobules: a potential model of autism spectrum disorder. Behavioural Brain Research. 187: 207-20. PMID 17983671 DOI: 10.1016/J.Bbr.2007.09.009  0.375
2007 Ferguson C, Hardy SL, Werner DF, Hileman SM, Delorey TM, Homanics GE. New insight into the role of the beta3 subunit of the GABAA-R in development, behavior, body weight regulation, and anesthesia revealed by conditional gene knockout. Bmc Neuroscience. 8: 85. PMID 17927825 DOI: 10.1186/1471-2202-8-85  0.785
2007 Kim J, Atherley R, Werner DF, Homanics GE, Carstens E, Antognini JF. Isoflurane depression of spinal nociceptive processing and minimum alveolar anesthetic concentration are not attenuated in mice expressing isoflurane resistant gamma-aminobutyric acid type-A receptors. Neuroscience Letters. 420: 209-12. PMID 17543455 DOI: 10.1016/J.Neulet.2007.04.057  0.657
2007 Lovinger DM, Homanics GE. Tonic for what ails us? high-affinity GABAA receptors and alcohol. Alcohol (Fayetteville, N.Y.). 41: 139-43. PMID 17521844 DOI: 10.1016/J.Alcohol.2007.03.008  0.507
2007 Winsky-Sommerer R, Vyazovskiy VV, Homanics GE, Tobler I. The EEG effects of THIP (Gaboxadol) on sleep and waking are mediated by the GABA(A)delta-subunit-containing receptors. The European Journal of Neuroscience. 25: 1893-9. PMID 17408425 DOI: 10.1111/J.1460-9568.2007.05455.X  0.398
2007 Sonner JM, Werner DF, Elsen FP, Xing Y, Liao M, Harris RA, Harrison NL, Fanselow MS, Eger EI, Homanics GE. Effect of isoflurane and other potent inhaled anesthetics on minimum alveolar concentration, learning, and the righting reflex in mice engineered to express alpha1 gamma-aminobutyric acid type A receptors unresponsive to isoflurane. Anesthesiology. 106: 107-13. PMID 17197852 DOI: 10.1097/00000542-200701000-00019  0.704
2007 Glykys J, Peng Z, Chandra D, Homanics GE, Houser CR, Mody I. A new naturally occurring GABA(A) receptor subunit partnership with high sensitivity to ethanol. Nature Neuroscience. 10: 40-8. PMID 17159992 DOI: 10.1038/Nn1813  0.833
2007 June HL, Foster KL, Eiler WJ, Goergen J, Cook JB, Johnson N, Mensah-Zoe B, Simmons JO, June HL, Yin W, Cook JM, Homanics GE. Dopamine and benzodiazepine-dependent mechanisms regulate the EtOH-enhanced locomotor stimulation in the GABAA alpha1 subunit null mutant mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 137-52. PMID 16710315 DOI: 10.1038/Sj.Npp.1301097  0.462
2006 Maison SF, Rosahl TW, Homanics GE, Liberman MC. Functional role of GABAergic innervation of the cochlea: phenotypic analysis of mice lacking GABA(A) receptor subunits alpha 1, alpha 2, alpha 5, alpha 6, beta 2, beta 3, or delta. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 10315-26. PMID 17021187 DOI: 10.1523/Jneurosci.2395-06.2006  0.384
2006 Chandra D, Jia F, Liang J, Peng Z, Suryanarayanan A, Werner DF, Spigelman I, Houser CR, Olsen RW, Harrison NL, Homanics GE. GABAA receptor alpha 4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol. Proceedings of the National Academy of Sciences of the United States of America. 103: 15230-5. PMID 17005728 DOI: 10.1073/Pnas.0604304103  0.843
2006 Skvorak K, Vissel B, Homanics GE. Production of conditional point mutant knockin mice. Genesis (New York, N.Y. : 2000). 44: 345-53. PMID 16832820 DOI: 10.1002/Dvg.20222  0.776
2006 Borghese CM, Werner DF, Topf N, Baron NV, Henderson LA, Boehm SL, Blednov YA, Saad A, Dai S, Pearce RA, Harris RA, Homanics GE, Harrison NL. An isoflurane- and alcohol-insensitive mutant GABA(A) receptor alpha(1) subunit with near-normal apparent affinity for GABA: characterization in heterologous systems and production of knockin mice. The Journal of Pharmacology and Experimental Therapeutics. 319: 208-18. PMID 16807363 DOI: 10.1124/Jpet.106.104406  0.738
2006 Werner DF, Blednov YA, Ariwodola OJ, Silberman Y, Logan E, Berry RB, Borghese CM, Matthews DB, Weiner JL, Harrison NL, Harris RA, Homanics GE. Knockin mice with ethanol-insensitive alpha1-containing gamma-aminobutyric acid type A receptors display selective alterations in behavioral responses to ethanol. The Journal of Pharmacology and Experimental Therapeutics. 319: 219-27. PMID 16785315 DOI: 10.1124/Jpet.106.106161  0.745
2006 Boehm SL, Homanics GE, Blednov YA, Harris RA. delta-Subunit containing GABAA receptor knockout mice are less sensitive to the actions of 4,5,6,7-tetrahydroisoxazolo-[5,4-c]pyridin-3-ol. European Journal of Pharmacology. 541: 158-62. PMID 16777089 DOI: 10.1016/J.Ejphar.2006.02.054  0.531
2006 Ponomarev I, Maiya R, Harnett MT, Schafer GL, Ryabinin AE, Blednov YA, Morikawa H, Boehm SL, Homanics GE, Berman AE, Berman A, Lodowski KH, Bergeson SE, Harris RA. Transcriptional signatures of cellular plasticity in mice lacking the alpha1 subunit of GABAA receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 5673-83. PMID 16723524 DOI: 10.1523/Jneurosci.0860-06.2006  0.447
2006 Homanics GE, Skvorak K, Ferguson C, Watkins S, Paul HS. Production and characterization of murine models of classic and intermediate maple syrup urine disease. Bmc Medical Genetics. 7: 33. PMID 16579849 DOI: 10.1186/1471-2350-7-33  0.751
2006 Elsen FP, Liljelund P, Werner DF, Olsen RW, Homanics GE, Harrison NL. GABA(A)-R alpha1 subunit knockin mutation leads to abnormal EEG and anesthetic-induced seizure-like activity in mice. Brain Research. 1078: 60-70. PMID 16490182 DOI: 10.1016/J.Brainres.2006.01.036  0.725
2006 Kralic JE, Sidler C, Parpan F, Homanics GE, Morrow AL, Fritschy JM. Compensatory alteration of inhibitory synaptic circuits in cerebellum and thalamus of gamma-aminobutyric acid type A receptor alpha1 subunit knockout mice. The Journal of Comparative Neurology. 495: 408-21. PMID 16485284 DOI: 10.1002/Cne.20866  0.643
2006 Ogris W, Lehner R, Fuchs K, Furtmüller B, Höger H, Homanics GE, Sieghart W. Investigation of the abundance and subunit composition of GABAA receptor subtypes in the cerebellum of alpha1-subunit-deficient mice. Journal of Neurochemistry. 96: 136-47. PMID 16277610 DOI: 10.1111/J.1471-4159.2005.03509.X  0.431
2006 Smith SS, Ruderman Y, Frye C, Homanics G, Yuan M. Steroid withdrawal in the mouse results in anxiogenic effects of 3α,5β-THP: A possible model of premenstrual dysphoric disorder Psychopharmacology. 186: 323-333. PMID 16193334 DOI: 10.1007/S00213-005-0168-3  0.348
2006 Kochanek PM, Vagni VA, Janesko KL, Washington CB, Crumrine PK, Garman RH, Jenkins LW, Clark RS, Homanics GE, Dixon CE, Schnermann J, Jackson EK. Adenosine A1 receptor knockout mice develop lethal status epilepticus after experimental traumatic brain injury. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 26: 565-75. PMID 16121125 DOI: 10.1038/Sj.Jcbfm.9600218  0.341
2005 Handforth A, Delorey TM, Homanics GE, Olsen RW. Pharmacologic evidence for abnormal thalamocortical functioning in GABA receptor beta3 subunit-deficient mice, a model of Angelman syndrome. Epilepsia. 46: 1860-70. PMID 16393151 DOI: 10.1111/J.1528-1167.2005.00287.X  0.384
2005 Liljelund P, Ferguson C, Homanics G, Olsen RW. Long-term effects of diazepam treatment of epileptic GABAA receptor beta3 subunit knockout mouse in early life. Epilepsy Research. 66: 99-115. PMID 16168624 DOI: 10.1016/J.Eplepsyres.2005.07.005  0.379
2005 Wiltgen BJ, Sanders MJ, Ferguson C, Homanics GE, Fanselow MS. Trace fear conditioning is enhanced in mice lacking the delta subunit of the GABAA receptor. Learning & Memory (Cold Spring Harbor, N.Y.). 12: 327-33. PMID 15897254 DOI: 10.1101/Lm.89705  0.489
2005 Liljelund P, Handforth A, Homanics GE, Olsen RW. GABAA receptor beta3 subunit gene-deficient heterozygous mice show parent-of-origin and gender-related differences in beta3 subunit levels, EEG, and behavior. Brain Research. Developmental Brain Research. 157: 150-61. PMID 15878204 DOI: 10.1016/J.Devbrainres.2005.03.014  0.388
2005 Chandra D, Korpi ER, Miralles CP, De Blas AL, Homanics GE. GABAA receptor gamma 2 subunit knockdown mice have enhanced anxiety-like behavior but unaltered hypnotic response to benzodiazepines. Bmc Neuroscience. 6: 30. PMID 15850489 DOI: 10.1186/1471-2202-6-30  0.821
2005 Sonner JM, Cascio M, Xing Y, Fanselow MS, Kralic JE, Morrow AL, Korpi ER, Hardy S, Sloat B, Eger EI, Homanics GE. Alpha 1 subunit-containing GABA type A receptors in forebrain contribute to the effect of inhaled anesthetics on conditioned fear. Molecular Pharmacology. 68: 61-8. PMID 15833735 DOI: 10.1124/Mol.104.009936  0.818
2005 Kralic JE, Criswell HE, Osterman JL, O'Buckley TK, Wilkie ME, Matthews DB, Hamre K, Breese GR, Homanics GE, Morrow AL. Genetic essential tremor in gamma-aminobutyric acidA receptor alpha1 subunit knockout mice. The Journal of Clinical Investigation. 115: 774-9. PMID 15765150 DOI: 10.1172/Jci23625  0.691
2005 Homanics GE, Elsen FP, Ying SW, Jenkins A, Ferguson C, Sloat B, Yuditskaya S, Goldstein PA, Kralic JE, Morrow AL, Harrison NL. A gain-of-function mutation in the GABA receptor produces synaptic and behavioral abnormalities in the mouse. Genes, Brain, and Behavior. 4: 10-9. PMID 15660664 DOI: 10.1111/J.1601-183X.2004.00090.X  0.669
2004 Panzanelli P, Homanics GE, Ottersen OP, Fritschy JM, Sassoè-Pognetto M. Pre- and postsynaptic GABA receptors at reciprocal dendrodendritic synapses in the olfactory bulb. The European Journal of Neuroscience. 20: 2945-52. PMID 15579148 DOI: 10.1111/J.1460-9568.2004.03776.X  0.46
2004 Shannon EE, Shelton KL, Vivian JA, Yount I, Morgan AR, Homanics GE, Grant KA. Discriminative stimulus effects of ethanol in mice lacking the gamma-aminobutyric acid type A receptor delta subunit. Alcoholism, Clinical and Experimental Research. 28: 906-13. PMID 15201633 DOI: 10.1097/01.Alc.0000128227.28794.42  0.505
2004 Uusi-Oukari M, Kosonen P, Homanics GE, Korpi ER. Brain regional heterogeneity of pH effects on GABA(A) receptor-associated [35s]TBPS binding. Neurochemical Research. 29: 771-80. PMID 15098940 DOI: 10.1023/B:Nere.0000018849.54169.C4  0.3
2004 Werner DF, Chandra D, Homanics GE. Genetically Engineered Animals in Alcohol Research Comprehensive Handbook of Alcohol Related Pathology. 3: 1583-1596. DOI: 10.1016/B978-012564370-2/50119-7  0.764
2003 Findlay GS, Phelan R, Roberts MT, Homanics GE, Bergeson SE, Lopreato GF, Mihic SJ, Blednov YA, Harris RA. Glycine receptor knock-in mice and hyperekplexia-like phenotypes: comparisons with the null mutant. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 8051-9. PMID 12954867 DOI: 10.1523/Jneurosci.23-22-08051.2003  0.477
2003 Sonner JM, Antognini JF, Dutton RC, Flood P, Gray AT, Harris RA, Homanics GE, Kendig J, Orser B, Raines DE, Rampil IJ, Trudell J, Vissel B, Eger EI. Inhaled anesthetics and immobility: mechanisms, mysteries, and minimum alveolar anesthetic concentration. Anesthesia and Analgesia. 97: 718-40. PMID 12933393 DOI: 10.1213/01.Ane.0000081063.76651.33  0.351
2003 Spigelman I, Li Z, Liang J, Cagetti E, Samzadeh S, Mihalek RM, Homanics GE, Olsen RW. Reduced inhibition and sensitivity to neurosteroids in hippocampus of mice lacking the GABA(A) receptor delta subunit. Journal of Neurophysiology. 90: 903-10. PMID 12702713 DOI: 10.1152/Jn.01022.2002  0.819
2003 Sinkkonen ST, Homanics GE, Korpi ER. Mouse models of Angelman syndrome, a neurodevelopmental disorder, display different brain regional GABA(A) receptor alterations. Neuroscience Letters. 340: 205-8. PMID 12672542 DOI: 10.1016/S0304-3940(03)00123-X  0.476
2003 Porcello DM, Huntsman MM, Mihalek RM, Homanics GE, Huguenard JR. Intact synaptic GABAergic inhibition and altered neurosteroid modulation of thalamic relay neurons in mice lacking delta subunit. Journal of Neurophysiology. 89: 1378-86. PMID 12626617 DOI: 10.1152/Jn.00899.2002  0.81
2003 Kralic JE, Wheeler M, Renzi K, Ferguson C, O'Buckley TK, Grobin AC, Morrow AL, Homanics GE. Deletion of GABAA receptor alpha 1 subunit-containing receptors alters responses to ethanol and other anesthetics. The Journal of Pharmacology and Experimental Therapeutics. 305: 600-7. PMID 12606632 DOI: 10.1124/Jpet.102.048124  0.684
2003 Ramadan E, Fu Z, Losi G, Homanics GE, Neale JH, Vicini S. GABA(A) receptor beta3 subunit deletion decreases alpha2/3 subunits and IPSC duration. Journal of Neurophysiology. 89: 128-34. PMID 12522165 DOI: 10.1152/Jn.00700.2002  0.445
2002 Homanics GE, Xu Y, Tang P. Integrated approaches to the action of general anesthetics and alcohol. Physiology & Behavior. 77: 495-9. PMID 12526989 DOI: 10.1016/S0031-9384(02)00910-1  0.308
2002 Goldstein PA, Elsen FP, Ying SW, Ferguson C, Homanics GE, Harrison NL. Prolongation of hippocampal miniature inhibitory postsynaptic currents in mice lacking the GABA(A) receptor alpha1 subunit. Journal of Neurophysiology. 88: 3208-17. PMID 12466441 DOI: 10.1152/Jn.00885.2001  0.506
2002 Wisor JP, DeLorey TM, Homanics GE, Edgar DM. Sleep states and sleep electroencephalographic spectral power in mice lacking the beta 3 subunit of the GABA(A) receptor. Brain Research. 955: 221-8. PMID 12419540 DOI: 10.1016/S0006-8993(02)03467-4  0.362
2002 Kralic JE, O'Buckley TK, Khisti RT, Hodge CW, Homanics GE, Morrow AL. GABA(A) receptor alpha-1 subunit deletion alters receptor subtype assembly, pharmacological and behavioral responses to benzodiazepines and zolpidem. Neuropharmacology. 43: 685-94. PMID 12367614 DOI: 10.1016/S0028-3908(02)00174-0  0.641
2002 Vicini S, Losi G, Homanics GE. GABA(A) receptor delta subunit deletion prevents neurosteroid modulation of inhibitory synaptic currents in cerebellar neurons. Neuropharmacology. 43: 646-50. PMID 12367609 DOI: 10.1016/S0028-3908(02)00126-0  0.501
2002 Quinlan JJ, Ferguson C, Jester K, Firestone LL, Homanics GE. Mice with glycine receptor subunit mutations are both sensitive and resistant to volatile anesthetics. Anesthesia and Analgesia. 95: 578-82, table of con. PMID 12198041 DOI: 10.1097/00000539-200209000-00016  0.448
2002 Kralic JE, Korpi ER, O'Buckley TK, Homanics GE, Morrow AL. Molecular and pharmacological characterization of GABA(A) receptor alpha1 subunit knockout mice. The Journal of Pharmacology and Experimental Therapeutics. 302: 1037-45. PMID 12183661 DOI: 10.1124/Jpet.102.036665  0.66
2002 Spigelman I, Li Z, Banerjee PK, Mihalek RM, Homanics GE, Olsen RW. Behavior and physiology of mice lacking the GABAA-receptor delta subunit. Epilepsia. 43: 3-8. PMID 12121286 DOI: 10.1046/J.1528-1157.43.S.5.8.X  0.812
2002 Koo JW, Homanics GE, Balaban CD. Hypoplasia of spiral and Scarpa's ganglion cells in GABA(A) receptor beta(3) subunit knockout mice. Hearing Research. 167: 71-80. PMID 12117532 DOI: 10.1016/S0378-5955(02)00348-9  0.453
2002 Peng Z, Hauer B, Mihalek RM, Homanics GE, Sieghart W, Olsen RW, Houser CR. GABA(A) receptor changes in delta subunit-deficient mice: altered expression of alpha4 and gamma2 subunits in the forebrain. The Journal of Comparative Neurology. 446: 179-97. PMID 11932935 DOI: 10.1002/Cne.10210  0.824
2002 Korpi ER, Mihalek RM, Sinkkonen ST, Hauer B, Hevers W, Homanics GE, Sieghart W, Lüddens H. Altered receptor subtypes in the forebrain of GABA(A) receptor delta subunit-deficient mice: recruitment of gamma 2 subunits. Neuroscience. 109: 733-43. PMID 11927155 DOI: 10.1016/S0306-4522(01)00527-9  0.808
2001 Mihalek RM, Bowers BJ, Wehner JM, Kralic JE, VanDoren MJ, Morrow AL, Homanics GE. GABA(A)-receptor delta subunit knockout mice have multiple defects in behavioral responses to ethanol. Alcoholism, Clinical and Experimental Research. 25: 1708-18. PMID 11781502 DOI: 10.1111/J.1530-0277.2001.Tb02179.X  0.837
2001 Dellovade TL, Davis AM, Ferguson C, Sieghart W, Homanics GE, Tobet SA. GABA influences the development of the ventromedial nucleus of the hypothalamus. Journal of Neurobiology. 49: 264-76. PMID 11745664 DOI: 10.1002/Neu.10011  0.495
2001 Nusser Z, Kay LM, Laurent G, Homanics GE, Mody I. Disruption of GABA(A) receptors on GABAergic interneurons leads to increased oscillatory power in the olfactory bulb network. Journal of Neurophysiology. 86: 2823-33. PMID 11731539 DOI: 10.1152/Jn.2001.86.6.2823  0.451
2001 Wong SM, Cheng G, Homanics GE, Kendig JJ. Enflurane actions on spinal cords from mice that lack the beta3 subunit of the GABA(A) receptor. Anesthesiology. 95: 154-64. PMID 11465553 DOI: 10.1097/00000542-200107000-00026  0.404
2001 Ugarte SD, Homanics GE, Hammond DL. Effect of embryonic knock-down of GABAA receptors on the levels of monoamines and their metabolites in the CNS of the mouse. Brain Research. 904: 290-7. PMID 11406127 DOI: 10.1016/S0006-8993(01)02475-1  0.488
2001 Vicini S, Ferguson C, Prybylowski K, Kralic J, Morrow AL, Homanics GE. GABA(A) receptor alpha1 subunit deletion prevents developmental changes of inhibitory synaptic currents in cerebellar neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 3009-16. PMID 11312285  0.609
2001 Sinkkonen ST, Mihalek RM, Homanics GE, Lüddens H, Korpi ER. Altered atypical coupling of gamma-aminobutyrate type A receptor agonist and convulsant binding sites in subunit-deficient mouse lines. Brain Research. Molecular Brain Research. 86: 179-83. PMID 11165384 DOI: 10.1016/S0169-328X(00)00273-4  0.817
2001 Tretter V, Hauer B, Nusser Z, Mihalek RM, Höger H, Homanics GE, Somogyi P, Sieghart W. Targeted disruption of the GABA(A) receptor delta subunit gene leads to an up-regulation of gamma 2 subunit-containing receptors in cerebellar granule cells. The Journal of Biological Chemistry. 276: 10532-8. PMID 11136737 DOI: 10.1074/Jbc.M011054200  0.809
2001 Vicini S, Ferguson C, Prybylowski K, Kralic J, Morrow AL, Homanics GE. GABAA receptor α1 subunit deletion prevents developmental changes of inhibitory synaptic currents in cerebellar neurons The Journal of Neuroscience. 21: 3009-3016. DOI: 10.1523/Jneurosci.21-09-03009.2001  0.609
2000 Uusi-Oukari M, Heikkilä J, Sinkkonen ST, Mäkelä R, Hauer B, Homanics GE, Sieghart W, Wisden W, Korpi ER. Long-range interactions in neuronal gene expression: evidence from gene targeting in the GABA(A) receptor beta2-alpha6-alpha1-gamma2 subunit gene cluster. Molecular and Cellular Neurosciences. 16: 34-41. PMID 10882481 DOI: 10.1006/Mcne.2000.0856  0.424
2000 Quinlan JJ, Firestone LL, Homanics GE. Mice lacking the long splice variant of the gamma 2 subunit of the GABA(A) receptor are more sensitive to benzodiazepines. Pharmacology, Biochemistry, and Behavior. 66: 371-4. PMID 10880692 DOI: 10.1016/S0091-3057(00)00225-2  0.53
2000 Ugarte SD, Homanics GE, Firestone LL, Hammond DL. Sensory thresholds and the antinociceptive effects of GABA receptor agonists in mice lacking the beta3 subunit of the GABA(A) receptor. Neuroscience. 95: 795-806. PMID 10670447 DOI: 10.1016/S0306-4522(99)00481-9  0.478
1999 Mihalek RM, Banerjee PK, Korpi ER, Quinlan JJ, Firestone LL, Mi ZP, Lagenaur C, Tretter V, Sieghart W, Anagnostaras SG, Sage JR, Fanselow MS, Guidotti A, Spigelman I, Li Z, ... ... Homanics GE, et al. Attenuated sensitivity to neuroactive steroids in gamma-aminobutyrate type A receptor delta subunit knockout mice. Proceedings of the National Academy of Sciences of the United States of America. 96: 12905-10. PMID 10536021 DOI: 10.1073/Pnas.96.22.12905  0.817
1999 Homanics GE, Quinlan JJ, Firestone LL. Pharmacologic and behavioral responses of inbred C57BL/6J and strain 129/SvJ mouse lines. Pharmacology, Biochemistry, and Behavior. 63: 21-6. PMID 10340519 DOI: 10.1016/S0091-3057(98)00232-9  0.35
1999 Homanics GE, Harrison NL, Quinlan JJ, Krasowski MD, Rick CE, de Blas AL, Mehta AK, Kist F, Mihalek RM, Aul JJ, Firestone LL. Normal electrophysiological and behavioral responses to ethanol in mice lacking the long splice variant of the gamma2 subunit of the gamma-aminobutyrate type A receptor. Neuropharmacology. 38: 253-65. PMID 10218866 DOI: 10.1016/S0028-3908(98)00177-4  0.841
1999 Schwartz DR, Homanics GE, Hoyt DG, Klein E, Abernethy J, Lazo JS. The neutral cysteine protease bleomycin hydrolase is essential for epidermal integrity and bleomycin resistance. Proceedings of the National Academy of Sciences of the United States of America. 96: 4680-5. PMID 10200322 DOI: 10.1073/Pnas.96.8.4680  0.352
1999 Huntsman MM, Porcello DM, Homanics GE, DeLorey TM, Huguenard JR. Reciprocal inhibitory connections and network synchrony in the mammalian thalamus. Science (New York, N.Y.). 283: 541-3. PMID 9915702 DOI: 10.1126/Science.283.5401.541  0.375
1998 Homanics GE, Quinlan JJ, Mihalek R, Firestone LL. Genetic dissection of the molecular target(s) of anesthetics with the gene knockout approach in mice. Toxicology Letters. 100: 301-7. PMID 10049157 DOI: 10.1016/S0378-4274(98)00199-4  0.76
1998 DeLorey TM, Handforth A, Anagnostaras SG, Homanics GE, Minassian BA, Asatourian A, Fanselow MS, Delgado-Escueta A, Ellison GD, Olsen RW. Mice lacking the beta3 subunit of the GABAA receptor have the epilepsy phenotype and many of the behavioral characteristics of Angelman syndrome. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 8505-14. PMID 9763493 DOI: 10.1523/Jneurosci.18-20-08505.1998  0.377
1998 Homanics GE, Quinlan JJ, Mihalek RM, Firestone LL. Alcohol and anesthetic mechanisms in genetically engineered mice. Frontiers in Bioscience : a Journal and Virtual Library. 3: D548-58. PMID 9616129 DOI: 10.2741/A302  0.771
1998 Quinlan JJ, Homanics GE, Firestone LL. Anesthesia sensitivity in mice that lack the beta3 subunit of the gamma-aminobutyric acid type A receptor. Anesthesiology. 88: 775-80. PMID 9523823 DOI: 10.1097/00000542-199803000-00030  0.513
1998 Homanics GE, Le NQ, Kist F, Mihalek R, Hart AR, Quinlan JJ. Ethanol tolerance and withdrawal responses in GABA(A) receptor alpha 6 subunit null allele mice and in inbred C57BL/6J and strain 129/SvJ mice. Alcoholism, Clinical and Experimental Research. 22: 259-65. PMID 9514316 DOI: 10.1111/J.1530-0277.1998.Tb03647.X  0.818
1998 Krasowski MD, Rick CE, Harrison NL, Firestone LL, Homanics GE. A deficit of functional GABA(A) receptors in neurons of beta 3 subunit knockout mice. Neuroscience Letters. 240: 81-4. PMID 9486477 DOI: 10.1016/S0304-3940(97)00929-4  0.46
1998 Quinlan JJ, Homanics GE, Firestone LL. MICE LACKING THE LONG SPLICE VARIANT OF THE [Greek small letter gamma]2 SUBUNIT OF THE GABAA RECEPTOR ARE MORE SENSITIVE TO BENZODIAZEPINES Anesthesiology. 89: 700A. DOI: 10.1097/00000542-199809130-00006  0.473
1997 Mäkelä R, Uusi-Oukari M, Homanics GE, Quinlan JJ, Firestone LL, Wisden W, Korpi ER. Cerebellar gamma-aminobutyric acid type A receptors: pharmacological subtypes revealed by mutant mouse lines. Molecular Pharmacology. 52: 380-8. PMID 9281599 DOI: 10.1124/Mol.52.3.380  0.475
1997 Homanics GE, DeLorey TM, Firestone LL, Quinlan JJ, Handforth A, Harrison NL, Krasowski MD, Rick CE, Korpi ER, Mäkelä R, Brilliant MH, Hagiwara N, Ferguson C, Snyder K, Olsen RW. Mice devoid of gamma-aminobutyrate type A receptor beta3 subunit have epilepsy, cleft palate, and hypersensitive behavior. Proceedings of the National Academy of Sciences of the United States of America. 94: 4143-8. PMID 9108119 DOI: 10.1073/Pnas.94.8.4143  0.473
1997 Homanics GE, Ferguson C, Quinlan JJ, Daggett J, Snyder K, Lagenaur C, Mi ZP, Wang XH, Grayson DR, Firestone LL. Gene knockout of the alpha6 subunit of the gamma-aminobutyric acid type A receptor: lack of effect on responses to ethanol, pentobarbital, and general anesthetics. Molecular Pharmacology. 51: 588-96. PMID 9106623 DOI: 10.1124/Mol.51.4.588  0.572
1997 Quinlan JJ, Homanics GE, Ferguson C, Firestone LL. A365 ANESTHESIA SENSITIVITY IN MICE LACKING THE beta3 SUBUNIT OF THE GABA sub A RECEPTOR Anesthesiology. 87: 365A. DOI: 10.1097/00000542-199709001-00365  0.451
1995 Homanics GE, de Silva HV, Osada J, Zhang SH, Wong H, Borensztajn J, Maeda N. Mild dyslipidemia in mice following targeted inactivation of the hepatic lipase gene. The Journal of Biological Chemistry. 270: 2974-80. PMID 7852377 DOI: 10.1074/Jbc.270.7.2974  0.317
1995 Homanics GE, Maeda N, Traber MG, Kayden HJ, Dehart DB, Sulik KK. Exencephaly and hydrocephaly in mice with targeted modification of the apolipoprotein B (Apob) gene. Teratology. 51: 1-10. PMID 7597652 DOI: 10.1002/Tera.1420510102  0.325
1995 Firestone LL, Quinlan JJ, Homanics GE. The role of γ-aminobutyric acid type-A receptor subtypes in the pharmacology of general anesthesia Current Opinion in Anaesthesiology. 8: 311-314. DOI: 10.1097/00001503-199508000-00006  0.383
1994 FIRESTONE LL, Quinlan JJ, Homanics G, Firestone S, Winter PM, Russell LB, Rinchik EM. HALOTHANE RESPONSES IN MICE WITH DELETION OF THE GENES ENCODING FOR GABAA RECEPTOR SUBUNITS α5 AND γ3 Anesthesiology. 81: A862. DOI: 10.1097/00000542-199409001-00861  0.408
1993 Homanics GE, Smith TJ, Zhang SH, Lee D, Young SG, Maeda N. Targeted modification of the apolipoprotein B gene results in hypobetalipoproteinemia and developmental abnormalities in mice. Proceedings of the National Academy of Sciences of the United States of America. 90: 2389-93. PMID 8460149 DOI: 10.1073/Pnas.90.6.2389  0.324
1991 Homanics GE. Morphological abnormalities, neonatal mortality, and reproductive abnormalities in mice transgenic for diphtheria toxin genes that are driven by the promoter for adipocyte lipid binding protein. Developmental Genetics. 12: 371-9. PMID 1806333 DOI: 10.1002/Dvg.1020120506  0.364
1990 Didion BA, Pomp D, Martin MJ, Homanics GE, Markert CL. Observations on the cooling and cryopreservation of pig oocytes at the germinal vesicle stage. Journal of Animal Science. 68: 2803-10. PMID 2211410 DOI: 10.2527/1990.6892803X  0.573
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