Mary Jeanne Kreek - Publications

Affiliations: 
Rockefeller University, New York, NY, United States 
Area:
Substance Abuse, Addiction

336 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Zhang Y, Randesi M, Blendy JA, Kreek MJ, Butelman ER. Impact of OPRM1 (Mu-opioid Receptor Gene) A112G Polymorphism on Dual Oxycodone and Cocaine Self-administration Behavior in a Mouse Model. Neuroscience. PMID 38211933 DOI: 10.1016/j.neuroscience.2024.01.002  0.399
2021 Yuferov V, Butelman ER, Randesi M, Ott J, Kreek MJ. Analyses of polymorphisms of intron 2 of OPRK1 (kappa-opioid receptor gene) in association with opioid and cocaine dependence diagnoses in an African-American population. Neuroscience Letters. 768: 136364. PMID 34843875 DOI: 10.1016/j.neulet.2021.136364  0.415
2021 Windisch KA, Mazid S, Johnson MA, Ashirova E, Zhou Y, Gergoire L, Warwick S, McEwen BS, Kreek MJ, Milner TA. Acute Delta 9-tetrahydrocannabinol administration differentially alters the hippocampal opioid system in adult female and male rats. Synapse (New York, N.Y.). PMID 34255372 DOI: 10.1002/syn.22218  0.781
2021 Butelman ER, Chen CY, Brown KG, Lake KJ, Kreek MJ. Age of onset of heaviest use of cannabis or alcohol in persons with severe opioid or cocaine use disorders. Drug and Alcohol Dependence. 226: 108834. PMID 34216857 DOI: 10.1016/j.drugalcdep.2021.108834  0.358
2021 Windisch KA, Morochnik M, Reed B, Kreek MJ. Nalmefene, a Mu Opioid Receptor Antagonist/Kappa Opioid Receptor Partial Agonist, Potentiates Cocaine Motivation But Not Intake with Extended Access Self-Administration in Adult Male Mice. Neuropharmacology. 108590. PMID 33974940 DOI: 10.1016/j.neuropharm.2021.108590  0.825
2021 Yuferov V, Butelman ER, Randesi M, van den Brink W, Blanken P, van Ree JM, Kreek MJ. Association of Serotonin Transporter (SERT) Polymorphisms with Opioid Dependence and Dimensional Aspects of Cocaine Use in a Caucasian Cohort of Opioid Users. Neuropsychiatric Disease and Treatment. 17: 659-670. PMID 33658787 DOI: 10.2147/NDT.S286536  0.382
2020 Rubin BR, Johnson MA, Berman JM, Goldstein E, Pertsovskaya V, Zhou Y, Contoreggi NH, Dyer AG, Gray JD, Waters EM, McEwen BS, Kreek MJ, Milner TA. Sex and chronic stress alter delta opioid receptor distribution within rat hippocampal CA1 pyramidal cells following behavioral challenges. Neurobiology of Stress. 13: 100236. PMID 33344692 DOI: 10.1016/J.Ynstr.2020.100236  0.343
2020 Peles E, Levran O, Randesi M, Ott J, Kreek MJ, Adelson M. Polymorphisms in Stress-Related Genes Are Associated with Reduced Cocaine Abuse and Longer Retention in Methadone Maintenance Treatment for Opioid Use Disorder. European Addiction Research. 1-8. PMID 33242852 DOI: 10.1159/000511898  0.313
2020 Reed B, Butelman ER, Kreek MJ. Kappa Opioid Receptor Antagonists as Potential Therapeutics for Mood and Substance Use Disorders. Handbook of Experimental Pharmacology. PMID 33174064 DOI: 10.1007/164_2020_401  0.343
2020 Butelman ER, Chen CY, Lake KJ, Brown KG, Kreek MJ. Bidirectional influence of heroin and cocaine escalation in persons with dual opioid and cocaine dependence diagnoses. Experimental and Clinical Psychopharmacology. PMID 33119382 DOI: 10.1037/pha0000401  0.364
2020 Windisch KA, Kreek MJ. Review of addiction risk potential associated with adolescent opioid use. Pharmacology, Biochemistry and Behavior. 198: 173022. PMID 32871141 DOI: 10.1016/J.Pbb.2020.173022  0.791
2020 Randesi M, Rotrosen J, Nunes EV, Lee JD, Novo P, Levran O, Ott J, Pavlicova M, Scodes J, Kreek MJ. Variants of opioid genes and response to treatment of opioid use disorder with buprenorphine-naloxone versus extended-release naltrexone in Caucasians. The American Journal of Drug and Alcohol Abuse. 1-8. PMID 32851876 DOI: 10.1080/00952990.2020.1797064  0.415
2020 Zhang Y, Kreek MJ. Nalfurafine modulates the reinforcing effects of oxycodone in male and female adolescent C57BL/6J mice. Neuropharmacology. 108244. PMID 32702404 DOI: 10.1016/J.Neuropharm.2020.108244  0.386
2020 Ashirova E, Contoreggi NH, Johnson MA, Al-Khayat FJ, Calcano GA, Rubin BR, O'Cinneide EM, Zhang Y, Zhou Y, Gregoire L, McEwen BS, Kreek MJ, Milner TA. Oxycodone injections not paired with conditioned place preference have little effect on the hippocampal opioid system in female and male rats. Synapse (New York, N.Y.). e22182. PMID 32654187 DOI: 10.1002/Syn.22182  0.395
2020 Kreek MJ, Zhang Y, Windisch KA, Dunn A. The Laboratory of the Biology of Addictive Diseases: Four Women in Neuroscience. Journal of Neuroscience Research. PMID 32640494 DOI: 10.1002/Jnr.24612  0.744
2020 Dunn A, Windisch K, Ben-Ezra A, Pikus P, Morochnik M, Erazo J, Reed B, Kreek MJ. Modulation of cocaine-related behaviors by low doses of the potent KOR agonist nalfurafine in male C57BL6 mice. Psychopharmacology. PMID 32435819 DOI: 10.1007/S00213-020-05543-7  0.811
2020 Reed B, Kreek MJ. Genetic Vulnerability to Opioid Addiction. Cold Spring Harbor Perspectives in Medicine. PMID 32205416 DOI: 10.1101/Cshperspect.A039735  0.41
2020 Butelman ER, Fry RS, Kimani R, Reed B, Kreek MJ. Neuroendocrine effects of naltrexone versus nalmefene in humans. Human Psychopharmacology. e2726. PMID 32050055 DOI: 10.1002/Hup.2726  0.384
2020 Valenza M, Windisch KA, Butelman ER, Reed B, Kreek MJ. Effects of Kappa opioid receptor blockade by LY2444296 HCl, a selective short-acting antagonist, during chronic extended access cocaine self-administration and re-exposure in rat. Psychopharmacology. PMID 31915862 DOI: 10.1007/S00213-019-05444-4  0.817
2019 Collins D, Zhang Y, Blendy J, Kreek MJ. Murine model of OPRM1 A118G alters oxycodone self-administration and locomotor activation, but not conditioned place preference. Neuropharmacology. 107864. PMID 31778689 DOI: 10.1016/J.Neuropharm.2019.107864  0.442
2019 Butelman ER, Chen CY, Brown KG, Kreek MJ. Escalation of drug use in persons dually diagnosed with opioid and cocaine dependence: Gender comparison and dimensional predictors. Drug and Alcohol Dependence. 205: 107657. PMID 31698322 DOI: 10.1016/J.Drugalcdep.2019.107657  0.438
2019 Levran O, Randesi M, Rotrosen J, Ott J, Adelson M, Kreek MJ. A 3' UTR SNP rs885863, a cis-eQTL for the circadian gene VIPR2 and lincRNA 689, is associated with opioid addiction. Plos One. 14: e0224399. PMID 31689297 DOI: 10.1371/Journal.Pone.0224399  0.328
2019 Zhou Y, Kreek MJ. Kappa Opioid Receptors and Mu Opioid Receptors as Combined Targets for Medication Development for Alcoholism. Biological Psychiatry. 86: 809-810. PMID 31668221 DOI: 10.1016/J.Biopsych.2019.08.011  0.39
2019 Kreek MJ, Reed B, Butelman ER. Current status of opioid addiction treatment and related preclinical research. Science Advances. 5: eaax9140. PMID 31616793 DOI: 10.1126/Sciadv.Aax9140  0.377
2019 Bellamy JR, Rubin BR, Zverovich A, Zhou Y, Contoreggi NH, Gray JD, McEwen BS, Kreek MJ, Milner TA. Sex and chronic stress differentially alter phosphorylated mu and delta opioid receptor levels in the rat hippocampus following oxycodone conditioned place preference. Neuroscience Letters. 134514. PMID 31560995 DOI: 10.1016/J.Neulet.2019.134514  0.371
2019 Butelman ER, Chen CY, Conybeare RA, Brown KG, Fry RS, Kimani R, Correa da Rosa J, Ott J, Kreek MJ. Are trait impulsivity and exposure to cannabis or alcohol associated with the age of trajectory of cocaine use? A gender-specific dimensional analysis in humans with cocaine dependence diagnosis. Experimental and Clinical Psychopharmacology. PMID 31424236 DOI: 10.1037/Pha0000314  0.395
2019 Zhou Y, Liang Y, Low MJ, Kreek MJ. Nuclear transcriptional changes in hypothalamus of Pomc enhancer knockout mice after excessive alcohol drinking. Genes, Brain, and Behavior. e12600. PMID 31339663 DOI: 10.1111/Gbb.12600  0.328
2019 Dunn A, Reed B, Erazo J, Ben-Ezra A, Kreek MJ. Signaling properties of structurally diverse kappa opioid receptor ligands: towards in vitro models of in vivo responses. Acs Chemical Neuroscience. PMID 31313902 DOI: 10.1021/Acschemneuro.9B00195  0.316
2019 Randesi M, Contoreggi NH, Zhou Y, Reich B, Bellamy JR, Yu F, Gray JD, McEwen BS, Milner TA, Kreek MJ. Sex differences in neuroplasticity- and stress-related gene expression and protein levels in the rat hippocampus following oxycodone conditioned place preference. Neuroscience. PMID 31071414 DOI: 10.1016/J.Neuroscience.2019.04.047  0.352
2019 Randesi M, van den Brink W, Levran O, Blanken P, van Ree JM, Ott J, Kreek MJ. VMAT2 gene (SLC18A2) variants associated with a greater risk for developing opioid dependence. Pharmacogenomics. PMID 30983500 DOI: 10.2217/Pgs-2018-0137  0.36
2019 Yuferov V, Randesi M, Butelman ER, van den Brink W, Blanken P, van Ree JM, Ott J, Kreek MJ. Association of variants of prodynorphin promoter 68-bp repeats in caucasians with opioid dependence diagnosis: Effect on age trajectory of heroin use. Neuroscience Letters. 704: 100-105. PMID 30936032 DOI: 10.1016/J.Neulet.2019.03.038  0.426
2019 Zhou Y, Kreek MJ. Combination of clinically utilized kappa opioid receptor agonist nalfurafine with low-dose naltrexone reduces excessive alcohol drinking in male and female mice. Alcoholism, Clinical and Experimental Research. PMID 30908671 DOI: 10.1111/Acer.14033  0.391
2019 Peles E, Levran O, Randesi M, Ott J, Kreek MJ, Adelson M. Genetic Variant in the CRH-binding Protein Gene (CRHBP) is Associated With Cessation of Cocaine Use in Methadone Maintenance Patients With Opioid Addiction. Journal of Addiction Medicine. PMID 30844877 DOI: 10.1097/Adm.0000000000000515  0.432
2019 Reich B, Zhou Y, Goldstein E, Srivats SS, Contoreggi NH, Kogan JF, McEwen BS, Kreek MJ, Milner TA, Gray JD. Chronic immobilization stress primes the hippocampal opioid system for oxycodone associated learning in female but not male rats. Synapse (New York, N.Y.). PMID 30632204 DOI: 10.1002/Syn.22088  0.313
2018 Windisch KA, Reed B, Kreek MJ. Naltrexone and Nalmefene Attenuate Cocaine Place Preference in Male Mice. Neuropharmacology. PMID 30048644 DOI: 10.1016/J.Neuropharm.2018.07.025  0.823
2018 Butelman ER, Chen CY, Fry RS, Kimani R, Levran O, Ott J, Correa da Rosa J, Kreek MJ. Re-evaluation of the KMSK scales, rapid dimensional measures of self-exposure to specific drugs: Gender-specific features. Drug and Alcohol Dependence. 190: 179-187. PMID 30041093 DOI: 10.1016/J.Drugalcdep.2018.05.028  0.315
2018 Butelman ER, Maremmani AGI, Bacciardi S, Chen CY, Correa da Rosa J, Kreek MJ. Non-medical Cannabis Self-Exposure as a Dimensional Predictor of Opioid Dependence Diagnosis: A Propensity Score Matched Analysis. Frontiers in Psychiatry. 9: 283. PMID 29997535 DOI: 10.3389/fpsyt.2018.00283  0.318
2018 Randesi M, Zhou Y, Mazid S, Odell SC, Gray JD, Correa da Rosa J, McEwen BS, Milner TA, Kreek MJ. Sex differences after chronic stress in the expression of opioid-, stress- and neuroplasticity-related genes in the rat hippocampus. Neurobiology of Stress. 8: 33-41. PMID 29888302 DOI: 10.1016/J.Ynstr.2018.01.001  0.35
2018 Yuferov V, Butelman ER, Kreek MJ. Gender-specific association of functional prodynorphin 68 bp repeats with cannabis exposure in an African American cohort. Neuropsychiatric Disease and Treatment. 14: 1025-1034. PMID 29713172 DOI: 10.2147/Ndt.S159954  0.347
2018 Dunn AD, Reed B, Guariglia C, Dunn AM, Hillman JM, Kreek MJ. Structurally-Related Kappa Opioid Receptor Agonists with Substantial Differential Signaling Bias: Neuroendocrine and Behavioral Effects in C57BL6 Mice. The International Journal of Neuropsychopharmacology. PMID 29635340 DOI: 10.1093/Ijnp/Pyy034  0.375
2017 Butelman ER, Kreek MJ. Medications for substance use disorders (SUD): emerging approaches. Expert Opinion On Emerging Drugs. 22: 301-315. PMID 29057665 DOI: 10.1080/14728214.2017.1395855  0.309
2017 Levran O, Peles E, Randesi M, da Rosa JC, Adelson M, Kreek MJ. The μ-opioid receptor nonsynonymous variant 118A>G is associated with prolonged abstinence from heroin without agonist treatment. Pharmacogenomics. PMID 28976288 DOI: 10.2217/Pgs-2017-0092  0.424
2017 Reed B, Butelman ER, Fry R, Kimani R, Kreek MJ. Repeated Administration of Opra Kappa (LY2456302), a Novel, Short-Acting, Selective KOP-r Antagonist, in Persons with and Without Cocaine Dependence. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 28857070 DOI: 10.1038/npp.2017.205  0.346
2017 Butelman ER, Bacciardi S, Maremmani AGI, Darst-Campbell M, Rosa JCd, Kreek MJ. Can a rapid measure of self‐exposure to drugs of abuse provide dimensional information on depression comorbidity? American Journal On Addictions. 26: 632-639. PMID 28654734 DOI: 10.1111/Ajad.12578  0.39
2017 Zhang Y, Liang Y, Levran O, Randesi M, Yuferov V, Zhao C, Kreek MJ. Alterations of expression of inflammation/immune-related genes in the dorsal and ventral striatum of adult C57BL/6J mice following chronic oxycodone self-administration: a RNA sequencing study. Psychopharmacology. PMID 28653080 DOI: 10.1007/S00213-017-4657-Y  0.405
2017 Valenza M, Butelman ER, Kreek MJ. "Effects of the novel relatively short-acting kappa opioid receptor antagonist LY2444296 in behaviors observed after chronic extended-access cocaine self-administration in rats". Psychopharmacology. PMID 28550455 DOI: 10.1007/S00213-017-4647-0  0.593
2017 Randesi M, Levran O, Correa da Rosa J, Hankins J, Rule J, Kreek MJ, Lee WM. Association of Variants of Arginine Vasopressin and Arginine Vasopressin Receptor 1A With Severe Acetaminophen Liver Injury. Cellular and Molecular Gastroenterology and Hepatology. 3: 500-505. PMID 28462386 DOI: 10.1016/J.Jcmgh.2017.01.008  0.376
2017 Randesi M, Levran O, Ott J, Blanken P, Brink Wvd, Ree JMv, Kreek MJ. Gene variants of the dopaminergic system are associated with non-dependent heroin use and heroin dependence Drug and Alcohol Dependence. 171. DOI: 10.1016/J.Drugalcdep.2016.08.476  0.32
2017 Guariglia C, Dunn A, Windisch K, Butelman E, Reed B, Kreek MJ. Partial kappa opioid receptor agonist effects in vivo in mice: Biased versus unbiased Drug and Alcohol Dependence. 171. DOI: 10.1016/J.Drugalcdep.2016.08.223  0.792
2017 Reed B, Butelman ER, Kreek MJ. Endogenous opioid system in addiction and addiction-related behaviors Current Opinion in Behavioral Sciences. 13: 196-202. DOI: 10.1016/J.Cobeha.2016.12.002  0.487
2016 Randesi M, van den Brink W, Levran O, Blanken P, Butelman ER, Yuferov V, da Rosa JC, Ott J, van Ree JM, Kreek MJ. Variants of opioid system genes are associated with non-dependent opioid use and heroin dependence. Drug and Alcohol Dependence. 168: 164-169. PMID 27664554 DOI: 10.1016/J.Drugalcdep.2016.08.634  0.442
2016 Zhang Y, Windisch K, Altschuler J, Rahm S, Butelman ER, Kreek MJ. Adolescent oxycodone self administration alters subsequent oxycodone-induced conditioned place preference and anti-nociceptive effect in C57BL/6J mice in adulthood. Neuropharmacology. PMID 27614221 DOI: 10.1016/j.neuropharm.2016.09.005  0.766
2016 Collins D, Reed B, Zhang Y, Kreek MJ. Sex differences in responsiveness to the prescription opioid oxycodone in mice. Pharmacology, Biochemistry, and Behavior. PMID 27316549 DOI: 10.1016/J.Pbb.2016.06.006  0.312
2016 Levran O, Randesi M, Peles E, Correa da Rosa J, Ott J, Rotrosen J, Adelson M, Kreek MJ. African-specific variability in the acetylcholine muscarinic receptor M4: association with cocaine and heroin addiction. Pharmacogenomics. PMID 27269905 DOI: 10.2217/Pgs-2016-0028  0.475
2016 Butelman ER, Kreek MJ. Discriminative Stimulus Properties of Opioid Ligands: Progress and Future Directions. Current Topics in Behavioral Neurosciences. 39: 175-192. PMID 27225498 DOI: 10.1007/7854_2016_9  0.319
2016 Valenza M, Picetti R, Yuferov V, Butelman ER, Kreek MJ. Strain and cocaine-induced differential opioid gene expression may predispose Lewis but not Fischer rats to escalate cocaine self-administration. Neuropharmacology. PMID 26777278 DOI: 10.1016/J.Neuropharm.2016.01.004  0.626
2015 Butelman ER, Kreek MJ. Salvinorin A, a kappa-opioid receptor agonist hallucinogen: pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disorders. Frontiers in Pharmacology. 6: 190. PMID 26441647 DOI: 10.3389/Fphar.2015.00190  0.411
2015 Schwantes-An TH, Zhang J, Chen LS, Hartz SM, Culverhouse RC, Chen X, Coon H, Frank J, Kamens HM, Konte B, Kovanen L, Latvala A, Legrand LN, Maher BS, Melroy WE, ... ... Kreek MJ, et al. Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts. Behavior Genetics. PMID 26392368 DOI: 10.1007/S10519-015-9737-3  0.422
2015 Levran O, Peles E, Randesi M, Correa da Rosa J, Ott J, Rotrosen J, Adelson M, Kreek MJ. Synaptic Plasticity and Signal Transduction Gene Polymorphisms and Vulnerability to Drug Addictions in Populations of European or African Ancestry. Cns Neuroscience & Therapeutics. 21: 898-904. PMID 26384852 DOI: 10.1111/Cns.12450  0.33
2015 Levran O, Peles E, Randesi M, Correa da Rosa J, Ott J, Rotrosen J, Adelson M, Kreek MJ. Susceptibility loci for heroin and cocaine addiction in the serotonergic and adrenergic pathways in populations of different ancestry. Pharmacogenomics. 1-14. PMID 26227246 DOI: 10.2217/Pgs.15.86  0.397
2015 Levy A, Marshall P, Zhou Y, Kreek MJ, Kent K, Daniels S, Shore A, Downs T, Fernandes MF, Mutch DM, Leri F. Fructose:glucose ratios--a study of sugar self-administration and associated neural and physiological responses in the rat. Nutrients. 7: 3869-90. PMID 26007337 DOI: 10.3390/Nu7053869  0.334
2015 Levran O, Randesi M, da Rosa JC, Ott J, Rotrosen J, Adelson M, Kreek MJ. Overlapping dopaminergic pathway genetic susceptibility to heroin and cocaine addictions in African Americans. Annals of Human Genetics. 79: 188-98. PMID 25875614 DOI: 10.1111/Ahg.12104  0.376
2015 Zhou Y, Kreek MJ. Persistent increases in rat hypothalamic POMC gene expression following chronic withdrawal from chronic "binge" pattern escalating-dose, but not steady-dose, cocaine. Neuroscience. 289: 63-70. PMID 25595971 DOI: 10.1016/J.Neuroscience.2014.12.078  0.455
2015 Zhang Y, Brownstein AJ, Buonora M, Niikura K, Ho A, Correa da Rosa J, Kreek MJ, Ott J. Self administration of oxycodone alters synaptic plasticity gene expression in the hippocampus differentially in male adolescent and adult mice. Neuroscience. 285: 34-46. PMID 25446355 DOI: 10.1016/J.Neuroscience.2014.11.013  0.375
2015 Zhou Y, Leri F, Cummins E, Kreek MJ. Individual differences in gene expression of vasopressin, D2 receptor, POMC and orexin: vulnerability to relapse to heroin-seeking in rats. Physiology & Behavior. 139: 127-35. PMID 25446223 DOI: 10.1016/J.Physbeh.2014.11.002  0.371
2015 Valenza M, Picetti R, Yuferov V, Kreek MJ. Predisposing genetic differences contribute to vulnerability to escalate cocaine intake in rats Drug and Alcohol Dependence. 146: e9. DOI: 10.1016/J.Drugalcdep.2014.09.705  0.569
2015 Ray BM, Ducat EA, Reed B, Altschuler J, Kreek MJ. CRF versus AVP in human stress responsivity: Initial studies Drug and Alcohol Dependence. 146. DOI: 10.1016/J.Drugalcdep.2014.09.577  0.306
2015 Randesi M, Levran O, Butelman E, Yuferov V, Ott J, Blanken P, Brink Wvd, Ree JMv, Kreek MJ. Gene variants of the opioid system – Relationship to heroin self-exposure, addiction, and treatment Drug and Alcohol Dependence. 146. DOI: 10.1016/J.Drugalcdep.2014.09.575  0.396
2015 Levran O, Peles E, Randesi M, Li Y, Rotrosen J, Ott J, Adelson M, Kreek MJ. Stress-related genes and heroin addiction: A role for functional fkbp5 variants Drug and Alcohol Dependence. 146. DOI: 10.1016/J.Drugalcdep.2014.09.395  0.407
2015 Ducat EA, Ray BM, Jackson J, Butelman E, Kreek MJ. Basal neuroendocrine status and cocaine craving measurements in active cocaine-dependent volunteers at admission and after 8 weeks of abstinence Drug and Alcohol Dependence. 146. DOI: 10.1016/J.Drugalcdep.2014.09.198  0.41
2014 Levran O, Peles E, Randesi M, Correa da Rosa J, Ott J, Rotrosen J, Adelson M, Kreek MJ. Dopaminergic pathway polymorphisms and heroin addiction: further support for association of CSNK1E variants. Pharmacogenomics. 15: 2001-9. PMID 25521358 DOI: 10.2217/Pgs.14.145  0.338
2014 Zaaijer ER, Bruijel J, Blanken P, Hendriks V, Koeter MW, Kreek MJ, Booij J, Goudriaan AE, van Ree JM, van den Brink W. Personality as a risk factor for illicit opioid use and a protective factor for illicit opioid dependence. Drug and Alcohol Dependence. 145: 101-5. PMID 25454407 DOI: 10.1016/J.Drugalcdep.2014.09.783  0.376
2014 Reed B, Butelman ER, Yuferov V, Randesi M, Kreek MJ. Genetics of opiate addiction. Current Psychiatry Reports. 16: 504. PMID 25209027 DOI: 10.1007/S11920-014-0504-6  0.372
2014 Zhou Y, Kreek MJ. Alcohol: a stimulant activating brain stress responsive systems with persistent neuroadaptation. Neuropharmacology. 87: 51-8. PMID 24929109 DOI: 10.1016/J.Neuropharm.2014.05.044  0.384
2014 Levran O, Peles E, Randesi M, Li Y, Rotrosen J, Ott J, Adelson M, Kreek MJ. Stress-related genes and heroin addiction: a role for a functional FKBP5 haplotype. Psychoneuroendocrinology. 45: 67-76. PMID 24845178 DOI: 10.1016/J.Psyneuen.2014.03.017  0.311
2014 Levran O, Randesi M, Li Y, Rotrosen J, Ott J, Adelson M, Kreek MJ. Drug addiction and stress-response genetic variability: association study in African Americans. Annals of Human Genetics. 78: 290-8. PMID 24766650 DOI: 10.1111/Ahg.12064  0.376
2014 Zhang Y, Mayer-Blackwell B, Schlussman SD, Randesi M, Butelman ER, Ho A, Ott J, Kreek MJ. Extended access oxycodone self-administration and neurotransmitter receptor gene expression in the dorsal striatum of adult C57BL/6 J mice. Psychopharmacology. 231: 1277-87. PMID 24221825 DOI: 10.1007/S00213-013-3306-3  0.319
2014 Mayer-Blackwell B, Schlussman SD, Butelman ER, Ho A, Ott J, Kreek MJ, Zhang Y. Self administration of oxycodone by adolescent and adult mice affects striatal neurotransmitter receptor gene expression. Neuroscience. 258: 280-91. PMID 24220688 DOI: 10.1016/J.Neuroscience.2013.10.062  0.344
2014 Zhang Y, Deutsch-Feldman M, Buonora M, Brownstein AJ, Niikura K, Ho A, Jurgott, Kreek MJ. Self-Administrationof Oxycodone by Adolescent and Adult Mice Differentially Affects Hypothalamic Mitochondrial Metabolism Gene Expression Journal of Alcoholism and Drug Dependence. 2: 1-6. DOI: 10.4172/2329-6488.1000153  0.335
2014 Zhou Y, Litvin Y, Pfaff D, Kreek M. Involvement of KOP-r in cocaine withdrawal-induced conditioned place aversion in rats Drug and Alcohol Dependence. 140: e250. DOI: 10.1016/J.Drugalcdep.2014.02.692  0.355
2014 Brownstein AJ, Zhang Y, Picetti R, Butelman E, Schlussman SD, Ho A, Aldrich JV, Kreek MJ. Effects of the short-acting KOP-r antagonist [D-TRP]CJ-15,208 on cocaine self-administration, locomotor activity, and food intake in male C57/BL6 mice Drug and Alcohol Dependence. 140. DOI: 10.1016/J.Drugalcdep.2014.02.081  0.417
2013 Peles E, Linzy S, Kreek MJ, Adelson M. Prospective study of QTc changes among former opiate addicts since admission to methadone maintenance treatment: benzodiazepine risk. Journal of Addiction Medicine. 7: 428-34. PMID 24145160 DOI: 10.1097/Adm.0B013E3182A8A4F2  0.384
2013 Lawhorn C, Yuferov V, Randesi M, Ho A, Morgello S, Kreek MJ, Levran O. Genetic diversity and linkage disequilibrium in the chemokine receptor CCR2-CCR5 region among individuals and populations. Cytokine. 64: 571-6. PMID 24011637 DOI: 10.1016/J.Cyto.2013.08.008  0.716
2013 Lawhorn C, Edusei E, Zhou Y, Ho A, Kreek MJ. Acute binge pattern cocaine administration induces region-specific effects in D1-r- and D2-r-expressing cells in eGFP transgenic mice. Neuroscience. 253: 123-31. PMID 24001687 DOI: 10.1016/J.Neuroscience.2013.08.032  0.747
2013 Niikura K, Ho A, Kreek MJ, Zhang Y. Oxycodone-induced conditioned place preference and sensitization of locomotor activity in adolescent and adult mice. Pharmacology, Biochemistry, and Behavior. 110: 112-6. PMID 23827650 DOI: 10.1016/J.Pbb.2013.06.010  0.319
2013 Zhou Y, Leri F, Ho A, Kreek MJ. Suppression of hypothalamic-pituitary-adrenal axis by acute heroin challenge in rats during acute and chronic withdrawal from chronic heroin administration. Neurochemical Research. 38: 1850-60. PMID 23771528 DOI: 10.1007/S11064-013-1091-3  0.344
2013 Levran O, Peles E, Randesi M, Shu X, Ott J, Shen PH, Adelson M, Kreek MJ. Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction. Pharmacogenomics. 14: 755-68. PMID 23651024 DOI: 10.2217/Pgs.13.58  0.388
2013 Picetti R, Schlussman SD, Zhou Y, Ray B, Ducat E, Yuferov V, Kreek MJ. Addictions and stress: clues for cocaine pharmacotherapies. Current Pharmaceutical Design. 19: 7065-80. PMID 23574443 DOI: 10.2174/13816128113199990610  0.491
2013 Zhou Y, Leri F, Grella SL, Aldrich JV, Kreek MJ. Involvement of dynorphin and kappa opioid receptor in yohimbine-induced reinstatement of heroin seeking in rats. Synapse (New York, N.Y.). 67: 358-61. PMID 23345075 DOI: 10.1002/Syn.21638  0.424
2013 Niikura K, Zhou Y, Ho A, Kreek MJ. Proopiomelanocortin (POMC) expression and conditioned place aversion during protracted withdrawal from chronic intermittent escalating-dose heroin in POMC-EGFP promoter transgenic mice. Neuroscience. 236: 220-32. PMID 23337531 DOI: 10.1016/J.Neuroscience.2012.12.071  0.346
2013 Zhang Y, Schlussman SD, Rabkin J, Butelman ER, Ho A, Kreek MJ. Chronic escalating cocaine exposure, abstinence/withdrawal, and chronic re-exposure: effects on striatal dopamine and opioid systems in C57BL/6J mice. Neuropharmacology. 67: 259-66. PMID 23164614 DOI: 10.1016/J.Neuropharm.2012.10.015  0.61
2013 Seip-Cammack KM, Reed B, Zhang Y, Ho A, Kreek MJ. Tolerance and sensitization to chronic escalating dose heroin following extended withdrawal in Fischer rats: possible role of mu-opioid receptors. Psychopharmacology. 225: 127-40. PMID 22829433 DOI: 10.1007/S00213-012-2801-2  0.393
2013 Levran O, Peles E, Hamon S, Randesi M, Adelson M, Kreek MJ. CYP2B6 SNPs are associated with methadone dose required for effective treatment of opioid addiction. Addiction Biology. 18: 709-16. PMID 21790905 DOI: 10.1111/J.1369-1600.2011.00349.X  0.33
2013 Ducat E, Ray B, Bart G, Umemura Y, Varon J, Ho A, Kreek MJ. Mu-opioid receptor A118G polymorphism in healthy volunteers affects hypothalamic-pituitary-adrenal axis adrenocorticotropic hormone stress response to metyrapone. Addiction Biology. 18: 325-31. PMID 21507151 DOI: 10.1111/J.1369-1600.2011.00313.X  0.426
2012 Zhou Y, Kruyer A, Ho A, Kreek MJ. Cocaine place conditioning increases pro-opiomelanocortin gene expression in rat hypothalamus. Neuroscience Letters. 530: 59-63. PMID 23069669 DOI: 10.1016/J.Neulet.2012.09.060  0.441
2012 Kreek MJ, Levran O, Reed B, Schlussman SD, Zhou Y, Butelman ER. Opiate addiction and cocaine addiction: underlying molecular neurobiology and genetics. The Journal of Clinical Investigation. 122: 3387-93. PMID 23023708 DOI: 10.1172/Jci60390  0.472
2012 Butelman ER, Yuferov V, Kreek MJ. κ-opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction. Trends in Neurosciences. 35: 587-96. PMID 22709632 DOI: 10.1016/J.Tins.2012.05.005  0.506
2012 Reed B, Fang N, Mayer-Blackwell B, Chen S, Yuferov V, Zhou Y, Kreek MJ. Chromatin alterations in response to forced swimming underlie increased prodynorphin transcription. Neuroscience. 220: 109-18. PMID 22698692 DOI: 10.1016/J.Neuroscience.2012.06.006  0.356
2012 Levran O, Yuferov V, Kreek MJ. The genetics of the opioid system and specific drug addictions. Human Genetics. 131: 823-42. PMID 22547174 DOI: 10.1007/S00439-012-1172-4  0.466
2012 Nielsen DA, Kreek MJ. Common and specific liability to addiction: approaches to association studies of opioid addiction. Drug and Alcohol Dependence. 123: S33-41. PMID 22542464 DOI: 10.1016/J.Drugalcdep.2012.03.026  0.64
2012 Zhang Y, Schlussman SD, Butelman ER, Ho A, Kreek MJ. Effects of withdrawal from chronic escalating-dose binge cocaine on conditioned place preference to cocaine and striatal preproenkephalin mRNA in C57BL/6J mice. Neuropharmacology. 63: 322-9. PMID 22504589 DOI: 10.1016/J.Neuropharm.2012.03.021  0.448
2012 Lovell KM, Vasiljevik T, Araya JJ, Lozama A, Prevatt-Smith KM, Day VW, Dersch CM, Rothman RB, Butelman ER, Kreek MJ, Prisinzano TE. Semisynthetic neoclerodanes as kappa opioid receptor probes. Bioorganic & Medicinal Chemistry. 20: 3100-10. PMID 22464684 DOI: 10.1016/J.Bmc.2012.02.040  0.338
2012 Butelman ER, Caspers M, Lovell KM, Kreek MJ, Prisinzano TE. Behavioral effects and central nervous system levels of the broadly available κ-agonist hallucinogen salvinorin A are affected by P-glycoprotein modulation in vivo. The Journal of Pharmacology and Experimental Therapeutics. 341: 802-8. PMID 22434677 DOI: 10.1124/Jpet.112.193227  0.327
2012 Nielsen DA, Ho A, Bahl A, Varma P, Kellogg S, Borg L, Kreek MJ. Former heroin addicts with or without a history of cocaine dependence are more impulsive than controls. Drug and Alcohol Dependence. 124: 113-20. PMID 22265192 DOI: 10.1016/J.Drugalcdep.2011.12.022  0.629
2012 Vanyukov MM, Tarter RE, Kirillova GP, Kirisci L, Reynolds MD, Kreek MJ, Conway KP, Maher BS, Iacono WG, Bierut L, Neale MC, Clark DB, Ridenour TA. Common liability to addiction and "gateway hypothesis": theoretical, empirical and evolutionary perspective. Drug and Alcohol Dependence. 123: S3-17. PMID 22261179 DOI: 10.1016/J.Drugalcdep.2011.12.018  0.3
2012 Picetti R, Caccavo JA, Ho A, Kreek MJ. Dose escalation and dose preference in extended-access heroin self-administration in Lewis and Fischer rats. Psychopharmacology. 220: 163-72. PMID 21894484 DOI: 10.1007/S00213-011-2464-4  0.33
2012 Seip KM, Reed B, Ho A, Kreek MJ. Measuring the incentive value of escalating doses of heroin in heroin-dependent Fischer rats during acute spontaneous withdrawal. Psychopharmacology. 219: 59-72. PMID 21748254 DOI: 10.1007/S00213-011-2380-7  0.362
2012 Leri F, Zhou Y, Carmichael B, Cummins E, Kreek MJ. Treatment-like steady-state methadone in rats interferes with incubation of cocaine sensitization and associated alterations in gene expression. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 22: 143-52. PMID 21745729 DOI: 10.1016/J.Euroneuro.2011.06.003  0.468
2012 Levran O, Peles E, Hamon S, Randesi M, Zhao C, Zhang B, Adelson M, Kreek MJ. Nerve growth factor β polypeptide (NGFB) genetic variability: association with the methadone dose required for effective maintenance treatment. The Pharmacogenomics Journal. 12: 319-27. PMID 21358750 DOI: 10.1038/Tpj.2011.6  0.354
2012 Crystal HA, Hamon S, Randesi M, Cook J, Anastos K, Lazar J, Liu C, Pearce L, Golub E, Valcour V, Weber KM, Holman S, Ho A, Kreek MJ. A C17T polymorphism in the mu opiate receptor is associated with quantitative measures of drug use in African American women. Addiction Biology. 17: 181-91. PMID 21070507 DOI: 10.1111/J.1369-1600.2010.00265.X  0.365
2012 Nielsen DA, Proudnikov D, Kreek MJ. The Genetics of Impulsivity The Oxford Handbook of Impulse Control Disorders. DOI: 10.1093/oxfordhb/9780195389715.013.0080  0.424
2011 Martin JA, Campbell A, Killip T, Kotz M, Krantz MJ, Kreek MJ, McCarroll BA, Mehta D, Payte JT, Stimmel B, Taylor T, Haigney MC, Wilford BB. QT interval screening in methadone maintenance treatment: report of a SAMHSA expert panel. Journal of Addictive Diseases. 30: 283-306. PMID 22026519 DOI: 10.1080/10550887.2011.610710  0.316
2011 Kreek MJ, Zhou Y, Levran O. Functions of arginine vasopressin and its receptors: importance of human molecular genetics studies in bidirectional translational research. Biological Psychiatry. 70: 502-3. PMID 21864735 DOI: 10.1016/J.Biopsych.2011.07.013  0.315
2011 Zhou Y, Litvin Y, Piras AP, Pfaff DW, Kreek MJ. Persistent increase in hypothalamic arginine vasopressin gene expression during protracted withdrawal from chronic escalating-dose cocaine in rodents. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 2062-75. PMID 21677651 DOI: 10.1038/Npp.2011.97  0.48
2011 Lane DA, Reed B, Kreek MJ, Pickel VM. Differential glutamate AMPA-receptor plasticity in subpopulations of VTA neurons in the presence or absence of residual cocaine: implications for the development of addiction. Neuropharmacology. 61: 1129-40. PMID 21215761 DOI: 10.1016/J.Neuropharm.2010.12.031  0.414
2011 Levran O, Awolesi O, Linzy S, Adelson M, Kreek MJ. Haplotype block structure of the genomic region of the mu opioid receptor gene. Journal of Human Genetics. 56: 147-55. PMID 21160491 DOI: 10.1038/Jhg.2010.150  0.378
2011 Yuferov V, Nielsen DA, Levran O, Randesi M, Hamon S, Ho A, Morgello S, Kreek MJ. Tissue-specific DNA methylation of the human prodynorphin gene in post-mortem brain tissues and PBMCs. Pharmacogenetics and Genomics. 21: 185-96. PMID 20808262 DOI: 10.1097/Fpc.0B013E32833Eecbc  0.539
2011 Rouault M, Nielsen DA, Ho A, Kreek MJ, Yuferov V. Cell-specific effects of variants of the 68-base pair tandem repeat on prodynorphin gene promoter activity. Addiction Biology. 16: 334-46. PMID 20731629 DOI: 10.1111/J.1369-1600.2010.00248.X  0.527
2010 Ho MK, Goldman D, Heinz A, Kaprio J, Kreek MJ, Li MD, Munafò MR, Tyndale RF. Breaking barriers in the genomics and pharmacogenetics of drug addiction. Clinical Pharmacology and Therapeutics. 88: 779-91. PMID 20981002 DOI: 10.1038/Clpt.2010.175  0.301
2010 Zhou Y, Maiya R, Norris EH, Kreek MJ, Strickland S. Involvement of tissue plasminogen activator in stress responsivity during acute cocaine withdrawal in mice. Stress (Amsterdam, Netherlands). 13: 481-90. PMID 20666641 DOI: 10.3109/10253891003786415  0.418
2010 Picetti R, Ho A, Butelman ER, Kreek MJ. Dose preference and dose escalation in extended-access cocaine self-administration in Fischer and Lewis rats. Psychopharmacology. 211: 313-23. PMID 20559822 DOI: 10.1007/S00213-010-1899-3  0.41
2010 Lane DA, Jaferi A, Kreek MJ, Pickel VM. Acute and chronic cocaine differentially alter the subcellular distribution of AMPA GluR1 subunits in region-specific neurons within the mouse ventral tegmental area. Neuroscience. 169: 559-73. PMID 20553819 DOI: 10.1016/J.Neuroscience.2010.05.056  0.436
2010 Nielsen DA, Ji F, Yuferov V, Ho A, He C, Ott J, Kreek MJ. Genome-wide association study identifies genes that may contribute to risk for developing heroin addiction. Psychiatric Genetics. 20: 207-14. PMID 20520587 DOI: 10.1097/Ypg.0B013E32833A2106  0.544
2010 Niikura K, Narita M, Butelman ER, Kreek MJ, Suzuki T. Neuropathic and chronic pain stimuli downregulate central mu-opioid and dopaminergic transmission. Trends in Pharmacological Sciences. 31: 299-305. PMID 20471111 DOI: 10.1016/J.Tips.2010.04.003  0.371
2010 Piras AP, Zhou Y, Schlussman SD, Ho A, Kreek MJ. Acute withdrawal from chronic escalating-dose binge cocaine administration alters kappa opioid receptor stimulation of [35S] guanosine 5'-O-[gamma-thio]triphosphate acid binding in the rat ventral tegmental area. Neuroscience. 169: 751-7. PMID 20452406 DOI: 10.1016/J.Neuroscience.2010.04.060  0.47
2010 Jackson CB, Varon J, Ho A, Marks KM, Talal AH, Kreek MJ. Identification of substance use and dependence among patients with viral hepatitis. Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association For the Study of the Liver. 42: 650-6. PMID 20418192 DOI: 10.1016/J.Dld.2010.03.002  0.386
2010 Kreek MJ, Borg L, Ducat E, Ray B. Pharmacotherapy in the treatment of addiction: methadone. Journal of Addictive Diseases. 29: 200-16. PMID 20407977 DOI: 10.1080/10550881003684798  0.347
2010 Kreek MJ. Overview and historical perspective of four papers presented on research related to the endogenous opioid system. Drug and Alcohol Dependence. 108: 195-9. PMID 20399574 DOI: 10.1016/J.Drugalcdep.2010.03.003  0.358
2010 Nielsen DA, Hamon S, Yuferov V, Jackson C, Ho A, Ott J, Kreek MJ. Ethnic diversity of DNA methylation in the OPRM1 promoter region in lymphocytes of heroin addicts. Human Genetics. 127: 639-49. PMID 20237803 DOI: 10.1007/S00439-010-0807-6  0.585
2010 Yuferov V, Levran O, Proudnikov D, Nielsen DA, Kreek MJ. Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment. Annals of the New York Academy of Sciences. 1187: 184-207. PMID 20201854 DOI: 10.1111/J.1749-6632.2009.05275.X  0.63
2010 Butelman ER, Rus S, Prisinzano TE, Kreek MJ. The discriminative effects of the kappa-opioid hallucinogen salvinorin A in nonhuman primates: dissociation from classic hallucinogen effects. Psychopharmacology. 210: 253-62. PMID 20084367 DOI: 10.1007/S00213-009-1771-5  0.411
2010 Briant JA, Nielsen DA, Proudnikov D, Londono D, Ho A, Ott J, Kreek MJ. Evidence for association of two variants of the nociceptin/orphanin FQ receptor gene OPRL1 with vulnerability to develop opiate addiction in Caucasians. Psychiatric Genetics. 20: 65-72. PMID 20032820 DOI: 10.1097/Ypg.0B013E32833511F6  0.591
2010 Proudnikov D, Kroslak T, Sipe JC, Randesi M, Li D, Hamon S, Ho A, Ott J, Kreek MJ. Association of polymorphisms of the cannabinoid receptor (CNR1) and fatty acid amide hydrolase (FAAH) genes with heroin addiction: impact of long repeats of CNR1. The Pharmacogenomics Journal. 10: 232-42. PMID 20010914 DOI: 10.1038/Tpj.2009.59  0.338
2010 Waldrop AE, Price KL, Desantis SM, Simpson AN, Back SE, McRae AL, Spratt EG, Kreek MJ, Brady KT. Community-dwelling cocaine-dependent men and women respond differently to social stressors versus cocaine cues. Psychoneuroendocrinology. 35: 798-806. PMID 20004523 DOI: 10.1016/J.Psyneuen.2009.11.005  0.411
2010 Back SE, Hartwell K, DeSantis SM, Saladin M, McRae-Clark AL, Price KL, Moran-Santa Maria MM, Baker NL, Spratt E, Kreek MJ, Brady KT. Reactivity to laboratory stress provocation predicts relapse to cocaine. Drug and Alcohol Dependence. 106: 21-7. PMID 19726138 DOI: 10.1016/J.Drugalcdep.2009.07.016  0.429
2010 Kreek MJ, Borg L, Zhou Y, Kravets I. Endocrine systems interacting with brain and behavior: Laboratory and clinical studies of heroin and other short-acting opiates versus methadone and other long-acting opioids Hormones, Brain and Behavior Online. 3177-3207. DOI: 10.1016/B978-008088783-8.00100-5  0.442
2009 Fox HC, Hong KI, Siedlarz KM, Bergquist K, Anderson G, Kreek MJ, Sinha R. Sex-specific dissociations in autonomic and HPA responses to stress and cues in alcohol-dependent patients with cocaine abuse. Alcohol and Alcoholism (Oxford, Oxfordshire). 44: 575-85. PMID 19793926 DOI: 10.1093/Alcalc/Agp060  0.323
2009 Levran O, Londono D, O'Hara K, Randesi M, Rotrosen J, Casadonte P, Linzy S, Ott J, Adelson M, Kreek MJ. Heroin addiction in African Americans: a hypothesis-driven association study. Genes, Brain, and Behavior. 8: 531-40. PMID 19500151 DOI: 10.1111/J.1601-183X.2009.00501.X  0.353
2009 Brady KT, McRae AL, Moran-Santa Maria MM, DeSantis SM, Simpson AN, Waldrop AE, Back SE, Kreek MJ. Response to corticotropin-releasing hormone infusion in cocaine-dependent individuals. Archives of General Psychiatry. 66: 422-30. PMID 19349312 DOI: 10.1001/Archgenpsychiatry.2009.9  0.423
2009 Maiya R, Zhou Y, Norris EH, Kreek MJ, Strickland S. Tissue plasminogen activator modulates the cellular and behavioral response to cocaine. Proceedings of the National Academy of Sciences of the United States of America. 106: 1983-8. PMID 19181855 DOI: 10.1073/Pnas.0812491106  0.439
2009 Kreek MJ, Zhou Y, Butelman ER, Levran O. Opiate and cocaine addiction: from bench to clinic and back to the bench. Current Opinion in Pharmacology. 9: 74-80. PMID 19155191 DOI: 10.1016/j.coph.2008.12.016  0.391
2009 Butelman ER, Prisinzano TE, Deng H, Rus S, Kreek MJ. Unconditioned behavioral effects of the powerful kappa-opioid hallucinogen salvinorin A in nonhuman primates: fast onset and entry into cerebrospinal fluid. The Journal of Pharmacology and Experimental Therapeutics. 328: 588-97. PMID 19001155 DOI: 10.1124/Jpet.108.145342  0.374
2009 Leri F, Zhou Y, Goddard B, Levy A, Jacklin D, Kreek MJ. Steady-state methadone blocks cocaine seeking and cocaine-induced gene expression alterations in the rat brain. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 19: 238-49. PMID 18990547 DOI: 10.1016/J.Euroneuro.2008.09.004  0.369
2009 Zhang Y, Landthaler M, Schlussman SD, Yuferov V, Ho A, Tuschl T, Kreek MJ. Mu opioid receptor knockdown in the substantia nigra/ventral tegmental area by synthetic small interfering RNA blocks the rewarding and locomotor effects of heroin. Neuroscience. 158: 474-83. PMID 18938225 DOI: 10.1016/J.Neuroscience.2008.09.039  0.361
2009 Yuferov V, Ji F, Nielsen DA, Levran O, Ho A, Morgello S, Shi R, Ott J, Kreek MJ. A functional haplotype implicated in vulnerability to develop cocaine dependence is associated with reduced PDYN expression in human brain. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 1185-97. PMID 18923396 DOI: 10.1038/Npp.2008.187  0.635
2009 Zhang Y, Picetti R, Butelman ER, Schlussman SD, Ho A, Kreek MJ. Behavioral and neurochemical changes induced by oxycodone differ between adolescent and adult mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 912-22. PMID 18784649 DOI: 10.1038/Npp.2008.134  0.339
2009 Kreek MJ, Schlussman SD, Reed B, Zhang Y, Nielsen DA, Levran O, Zhou Y, Butelman ER. Bidirectional translational research: Progress in understanding addictive diseases. Neuropharmacology. 56: 32-43. PMID 18725235 DOI: 10.1016/j.neuropharm.2008.07.042  0.58
2009 Nielsen DA, Yuferov V, Hamon S, Jackson C, Ho A, Ott J, Kreek MJ. Increased OPRM1 DNA methylation in lymphocytes of methadone-maintained former heroin addicts. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 867-73. PMID 18650805 DOI: 10.1038/Npp.2008.108  0.555
2009 Nielsen DA, Yuferov V, Hamon S, Jackson C, Ho A, Ott J, Kreek MJ. Increased OPRM1 DNA methylation in lymphocytes of methadone (Neuropsychopharmacology (2008) DOI: 10.1038/npp.2008.108) Neuropsychopharmacology. 34: 1087. DOI: 10.1038/Npp.2008.155  0.496
2008 Devidze N, Zhou Y, Ho A, Zhang Q, Pfaff DW, Kreek MJ. Steady-state methadone effect on generalized arousal in male and female mice. Behavioral Neuroscience. 122: 1248-56. PMID 19045944 DOI: 10.1037/A0013276  0.351
2008 Peles E, Linzy S, Kreek MJ, Adelson M. One-year and cumulative retention as predictors of success in methadone maintenance treatment: A comparison of two clinics in the United States and Israel Journal of Addictive Diseases. 27: 11-25. PMID 19042587 DOI: 10.1080/10550880802324382  0.334
2008 Lane DA, Lessard AA, Chan J, Colago EE, Zhou Y, Schlussman SD, Kreek MJ, Pickel VM. Region-specific changes in the subcellular distribution of AMPA receptor GluR1 subunit in the rat ventral tegmental area after acute or chronic morphine administration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 9670-81. PMID 18815253 DOI: 10.1523/Jneurosci.2151-08.2008  0.365
2008 Butelman ER, Rus S, Simpson DS, Wolf A, Prisinzano TE, Kreek MJ. The effects of herkinorin, the first mu-selective ligand from a salvinorin A-derived scaffold, in a neuroendocrine biomarker assay in nonhuman primates. The Journal of Pharmacology and Experimental Therapeutics. 327: 154-60. PMID 18593955 DOI: 10.1124/Jpet.108.140079  0.387
2008 Levran O, Londono D, O'Hara K, Nielsen DA, Peles E, Rotrosen J, Casadonte P, Linzy S, Randesi M, Ott J, Adelson M, Kreek MJ. Genetic susceptibility to heroin addiction: a candidate gene association study. Genes, Brain, and Behavior. 7: 720-9. PMID 18518925 DOI: 10.1111/J.1601-183X.2008.00410.X  0.573
2008 Zhou Y, Cui CL, Schlussman SD, Choi JC, Ho A, Han JS, Kreek MJ. Effects of cocaine place conditioning, chronic escalating-dose "binge" pattern cocaine administration and acute withdrawal on orexin/hypocretin and preprodynorphin gene expressions in lateral hypothalamus of Fischer and Sprague-Dawley rats. Neuroscience. 153: 1225-34. PMID 18436386 DOI: 10.1016/j.neuroscience.2008.03.023  0.352
2008 Levran O, O'Hara K, Peles E, Li D, Barral S, Ray B, Borg L, Ott J, Adelson M, Kreek MJ. ABCB1 (MDR1) genetic variants are associated with methadone doses required for effective treatment of heroin dependence. Human Molecular Genetics. 17: 2219-27. PMID 18424454 DOI: 10.1093/Hmg/Ddn122  0.343
2008 Proudnikov D, Hamon S, Ott J, Kreek MJ. Association of polymorphisms in the melanocortin receptor type 2 (MC2R, ACTH receptor) gene with heroin addiction. Neuroscience Letters. 435: 234-9. PMID 18359160 DOI: 10.1016/J.Neulet.2008.02.042  0.302
2008 Glass MJ, Lane DA, Colago EE, Chan J, Schlussman SD, Zhou Y, Kreek MJ, Pickel VM. Chronic administration of morphine is associated with a decrease in surface AMPA GluR1 receptor subunit in dopamine D1 receptor expressing neurons in the shell and non-D1 receptor expressing neurons in the core of the rat nucleus accumbens. Experimental Neurology. 210: 750-61. PMID 18294632 DOI: 10.1016/J.Expneurol.2008.01.012  0.391
2008 Oosterhuis BE, LaForge KS, Proudnikov D, Ho A, Nielsen DA, Gianotti R, Barral S, Gordon D, Leal SM, Ott J, Kreek MJ. Catechol-O-methyltransferase (COMT) gene variants: possible association of the Val158Met variant with opiate addiction in Hispanic women. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 147: 793-8. PMID 18270997 DOI: 10.1002/Ajmg.B.30716  0.551
2008 Nielsen DA, Ji F, Yuferov V, Ho A, Chen A, Levran O, Ott J, Kreek MJ. Genotype patterns that contribute to increased risk for or protection from developing heroin addiction. Molecular Psychiatry. 13: 417-28. PMID 18195715 DOI: 10.1038/Sj.Mp.4002147  0.588
2008 Nielsen DA, Barral S, Proudnikov D, Kellogg S, Ho A, Ott J, Kreek MJ. TPH2 and TPH1: association of variants and interactions with heroin addiction. Behavior Genetics. 38: 133-50. PMID 18181017 DOI: 10.1007/S10519-007-9187-7  0.556
2008 Butelman ER, Reed B, Chait BT, Mandau M, Yuferov V, Kreek MJ. Limited effects of beta-endorphin compared to loperamide or fentanyl in a neuroendocrine biomarker assay in non-human primates. Psychoneuroendocrinology. 33: 292-304. PMID 18171605 DOI: 10.1016/J.Psyneuen.2007.11.011  0.342
2008 Zhou Y, Leri F, Cummins E, Hoeschele M, Kreek MJ. Involvement of arginine vasopressin and V1b receptor in heroin withdrawal and heroin seeking precipitated by stress and by heroin. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 226-36. PMID 17443128 DOI: 10.1038/Sj.Npp.1301419  0.382
2008 Nielsen D, Yuferov V, Hamon S, Jackson C, Ott J, Kreek MJ. 55. Increased DNA methylation in the promoter region of the μ-opioid receptor gene (ORPM1) in lymphocytes of Caucasian methadone maintained former heroin addicts Brain Behavior and Immunity. 22: 16-17. DOI: 10.1016/J.Bbi.2008.04.056  0.605
2007 Kroslak T, Laforge KS, Gianotti RJ, Ho A, Nielsen DA, Kreek MJ. The single nucleotide polymorphism A118G alters functional properties of the human mu opioid receptor. Journal of Neurochemistry. 103: 77-87. PMID 17877633 DOI: 10.1111/J.1471-4159.2007.04738.X  0.596
2007 Koob G, Kreek MJ. Stress, dysregulation of drug reward pathways, and the transition to drug dependence. The American Journal of Psychiatry. 164: 1149-59. PMID 17671276 DOI: 10.1176/Appi.Ajp.2007.05030503  0.383
2007 Bailey A, Gianotti R, Ho A, Kreek MJ. Downregulation of kappa-opioid receptors in basolateral amygdala and septum of rats withdrawn for 14 days from an escalating dose "binge" cocaine administration paradigm. Synapse (New York, N.Y.). 61: 820-6. PMID 17621646 DOI: 10.1002/syn.20436  0.354
2007 Williams TJ, LaForge KS, Gordon D, Bart G, Kellogg S, Ott J, Kreek MJ. Prodynorphin gene promoter repeat associated with cocaine/alcohol codependence. Addiction Biology. 12: 496-502. PMID 17559549 DOI: 10.1111/J.1369-1600.2007.00069.X  0.364
2007 Kreek MJ, LaForge KS. Stress responsivity, addiction, and a functional variant of the human mu-opioid receptor gene. Molecular Interventions. 7: 74-8. PMID 17468387 DOI: 10.1124/mi.7.2.7  0.329
2007 Nielsen DA, Leidner M, Haynes C, Krauthammer M, Kreek MJ. The BiolAD-DB system : an informatics system for clinical and genetic data. Molecular Diagnosis & Therapy. 11: 15-9. PMID 17286447 DOI: 10.1007/Bf03256219  0.494
2007 Zhou Y, Adomako-Mensah J, Yuferov V, Ho A, Zhang J, Xu M, Kreek MJ. Effects of acute "binge" cocaine on mRNA levels of mu opioid receptor and neuropeptides in dopamine D1 or D3 receptor knockout mice. Synapse (New York, N.Y.). 61: 50-9. PMID 17068774 DOI: 10.1002/Syn.20340  0.41
2007 Butelman ER, Mandau M, Tidgewell K, Prisinzano TE, Yuferov V, Kreek MJ. Effects of salvinorin A, a kappa-opioid hallucinogen, on a neuroendocrine biomarker assay in nonhuman primates with high kappa-receptor homology to humans. The Journal of Pharmacology and Experimental Therapeutics. 320: 300-6. PMID 17060493 DOI: 10.1124/Jpet.106.112417  0.4
2007 Kuzmin A, Kreek MJ, Bakalkin G, Liljequist S. The nociceptin/orphanin FQ receptor agonist Ro 64-6198 reduces alcohol self-administration and prevents relapse-like alcohol drinking. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 902-10. PMID 16880770 DOI: 10.1038/Sj.Npp.1301169  0.363
2006 Zhou Y, Bendor J, Hofmann L, Randesi M, Ho A, Kreek MJ. Mu opioid receptor and orexin/hypocretin mRNA levels in the lateral hypothalamus and striatum are enhanced by morphine withdrawal. The Journal of Endocrinology. 191: 137-45. PMID 17065397 DOI: 10.1677/Joe.1.06960  0.43
2006 Kellogg S, Melia D, Khuri E, Lin A, Ho A, Kreek MJ. Adolescent and young adult heroin patients: drug use and success in methadone maintenance treatment. Journal of Addictive Diseases. 25: 15-25. PMID 16956865 DOI: 10.1300/J069V25N03_03  0.341
2006 Bart G, LaForge KS, Borg L, Lilly C, Ho A, Kreek MJ. Altered levels of basal cortisol in healthy subjects with a 118G allele in exon 1 of the Mu opioid receptor gene. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 2313-7. PMID 16794569 DOI: 10.1038/Sj.Npp.1301128  0.388
2006 Aouizerate B, Ho A, Schluger JH, Perret G, Borg L, Le Moal M, Piazza PV, Kreek MJ. Glucocorticoid negative feedback in methadone-maintained former heroin addicts with ongoing cocaine dependence: dose-response to dexamethasone suppression. Addiction Biology. 11: 84-96. PMID 16759341 DOI: 10.1111/J.1369-1600.2006.00006.X  0.434
2006 Peles E, Kreek MJ, Kellogg S, Adelson M. High methadone dose significantly reduces cocaine use in methadone maintenance treatment (MMT) patients. Journal of Addictive Diseases. 25: 43-50. PMID 16597572 DOI: 10.1300/J069V25N01_07  0.427
2006 Zhang Y, Svenningsson P, Picetti R, Schlussman SD, Nairn AC, Ho A, Greengard P, Kreek MJ. Cocaine self-administration in mice is inversely related to phosphorylation at Thr34 (protein kinase A site) and Ser130 (kinase CK1 site) of DARPP-32. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 2645-51. PMID 16525043 DOI: 10.1523/Jneurosci.3923-05.2006  0.4
2006 Sinha R, Garcia M, Paliwal P, Kreek MJ, Rounsaville BJ. Stress-induced cocaine craving and hypothalamic-pituitary-adrenal responses are predictive of cocaine relapse outcomes. Archives of General Psychiatry. 63: 324-31. PMID 16520439 DOI: 10.1001/Archpsyc.63.3.324  0.429
2006 Fox HC, Garcia M, Kemp K, Milivojevic V, Kreek MJ, Sinha R. Gender differences in cardiovascular and corticoadrenal response to stress and drug cues in cocaine dependent individuals. Psychopharmacology. 185: 348-57. PMID 16514523 DOI: 10.1007/S00213-005-0303-1  0.421
2006 Leri F, Zhou Y, Goddard B, Cummins E, Kreek MJ. Effects of high-dose methadone maintenance on cocaine place conditioning, cocaine self-administration, and mu-opioid receptor mRNA expression in the rat brain. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 1462-74. PMID 16237390 DOI: 10.1038/Sj.Npp.1300927  0.47
2005 Kreek MJ, Nielsen DA, Butelman ER, LaForge KS. Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction. Nature Neuroscience. 8: 1450-7. PMID 16251987 DOI: 10.1038/Nn1583  0.555
2005 Schlussman SD, Zhou Y, Bailey A, Ho A, Kreek MJ. Steady-dose and escalating-dose "binge" administration of cocaine alter expression of behavioral stereotypy and striatal preprodynorphin mRNA levels in rats. Brain Research Bulletin. 67: 169-75. PMID 16144651 DOI: 10.1016/J.Brainresbull.2005.04.018  0.395
2005 Schmidt MD, Schmidt MS, Butelman ER, Harding WW, Tidgewell K, Murry DJ, Kreek MJ, Prisinzano TE. Pharmacokinetics of the plant-derived kappa-opioid hallucinogen salvinorin A in nonhuman primates. Synapse (New York, N.Y.). 58: 208-10. PMID 16138318 DOI: 10.1002/Syn.20191  0.304
2005 Zhou Y, Bendor JT, Yuferov V, Schlussman SD, Ho A, Kreek MJ. Amygdalar vasopressin mRNA increases in acute cocaine withdrawal: evidence for opioid receptor modulation. Neuroscience. 134: 1391-7. PMID 16039786 DOI: 10.1016/J.Neuroscience.2005.05.032  0.502
2005 Glass MJ, Kruzich PJ, Colago EE, Kreek MJ, Pickel VM. Increased AMPA GluR1 receptor subunit labeling on the plasma membrane of dendrites in the basolateral amygdala of rats self-administering morphine. Synapse (New York, N.Y.). 58: 1-12. PMID 16037950 DOI: 10.1002/Syn.20176  0.399
2005 Bart G, Schluger JH, Borg L, Ho A, Bidlack JM, Kreek MJ. Nalmefene induced elevation in serum prolactin in normal human volunteers: partial kappa opioid agonist activity? Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 30: 2254-62. PMID 15988468 DOI: 10.1038/Sj.Npp.1300811  0.454
2005 Fox HC, Talih M, Malison R, Anderson GM, Kreek MJ, Sinha R. Frequency of recent cocaine and alcohol use affects drug craving and associated responses to stress and drug-related cues. Psychoneuroendocrinology. 30: 880-91. PMID 15975729 DOI: 10.1016/J.Psyneuen.2005.05.002  0.407
2005 Bailey A, Yuferov V, Bendor J, Schlussman SD, Zhou Y, Ho A, Kreek MJ. Immediate withdrawal from chronic "binge" cocaine administration increases mu-opioid receptor mRNA levels in rat frontal cortex. Brain Research. Molecular Brain Research. 137: 258-62. PMID 15950784 DOI: 10.1016/J.Molbrainres.2005.02.017  0.471
2005 Bailey A, Gianotti R, Ho A, Kreek MJ. Persistent upregulation of mu-opioid, but not adenosine, receptors in brains of long-term withdrawn escalating dose "binge" cocaine-treated rats. Synapse (New York, N.Y.). 57: 160-6. PMID 15945065 DOI: 10.1002/Syn.20168  0.479
2005 Yuferov V, Nielsen D, Butelman E, Kreek MJ. Microarray studies of psychostimulant-induced changes in gene expression. Addiction Biology. 10: 101-18. PMID 15849024 DOI: 10.1080/13556210412331308976  0.603
2005 Kreek MJ, Bart G, Lilly C, LaForge KS, Nielsen DA. Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments. Pharmacological Reviews. 57: 1-26. PMID 15734726 DOI: 10.1124/Pr.57.1.1  0.677
2005 Zhang Y, Butelman ER, Schlussman SD, Ho A, Kreek MJ. Effects of the plant-derived hallucinogen salvinorin A on basal dopamine levels in the caudate putamen and in a conditioned place aversion assay in mice: agonist actions at kappa opioid receptors. Psychopharmacology. 179: 551-8. PMID 15682306 DOI: 10.1007/S00213-004-2087-0  0.417
2005 Bart G, Kreek MJ, Ott J, LaForge KS, Proudnikov D, Pollak L, Heilig M. Increased attributable risk related to a functional mu-opioid receptor gene polymorphism in association with alcohol dependence in central Sweden. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 30: 417-22. PMID 15525999 DOI: 10.1038/Sj.Npp.1300598  0.359
2005 Kreek MJ. Impact of bidirectional translational research on treatment of addiction Clinical Neuroscience Research. 5: 123-139. DOI: 10.1016/J.Cnr.2005.08.008  0.303
2004 Yuferov V, Fussell D, LaForge KS, Nielsen DA, Gordon D, Ho A, Leal SM, Ott J, Kreek MJ. Redefinition of the human kappa opioid receptor gene (OPRK1) structure and association of haplotypes with opiate addiction. Pharmacogenetics. 14: 793-804. PMID 15608558 DOI: 10.1097/00008571-200412000-00002  0.623
2004 Zhou Y, Spangler R, Yuferov VP, Schlussmann SD, Ho A, Kreek MJ. Effects of selective D1- or D2-like dopamine receptor antagonists with acute "binge" pattern cocaine on corticotropin-releasing hormone and proopiomelanocortin mRNA levels in the hypothalamus. Brain Research. Molecular Brain Research. 130: 61-7. PMID 15519677 DOI: 10.1016/J.Molbrainres.2004.07.008  0.438
2004 Kreek MJ, Schlussman SD, Bart G, Laforge KS, Butelman ER. Evolving perspectives on neurobiological research on the addictions: celebration of the 30th anniversary of NIDA. Neuropharmacology. 47: 324-44. PMID 15464148 DOI: 10.1016/J.Neuropharm.2004.07.024  0.413
2004 Glass MJ, Kruzich PJ, Kreek MJ, Pickel VM. Decreased plasma membrane targeting of NMDA-NR1 receptor subunit in dendrites of medial nucleus tractus solitarius neurons in rats self-administering morphine. Synapse (New York, N.Y.). 53: 191-201. PMID 15266550 DOI: 10.1002/Syn.20049  0.328
2004 Butelman ER, Harris TJ, Kreek MJ. Antiallodynic effects of loperamide and fentanyl against topical capsaicin-induced allodynia in unanesthetized primates. The Journal of Pharmacology and Experimental Therapeutics. 311: 155-63. PMID 15152028 DOI: 10.1124/Jpet.104.068411  0.332
2004 Mantsch JR, Yuferov V, Mathieu-Kia AM, Ho A, Kreek MJ. Effects of extended access to high versus low cocaine doses on self-administration, cocaine-induced reinstatement and brain mRNA levels in rats. Psychopharmacology. 175: 26-36. PMID 15042275 DOI: 10.1007/S00213-004-1778-X  0.718
2004 Bart G, Heilig M, LaForge KS, Pollak L, Leal SM, Ott J, Kreek MJ. Substantial attributable risk related to a functional mu-opioid receptor gene polymorphism in association with heroin addiction in central Sweden. Molecular Psychiatry. 9: 547-9. PMID 15037869 DOI: 10.1038/Sj.Mp.4001504  0.408
2004 Kreek MJ, Nielsen DA, LaForge KS. Genes associated with addiction: alcoholism, opiate, and cocaine addiction. Neuromolecular Medicine. 5: 85-108. PMID 15001815 DOI: 10.1385/Nmm:5:1:085  0.616
2004 Zhang Y, Butelman ER, Schlussman SD, Ho A, Kreek MJ. Effect of the kappa opioid agonist R-84760 on cocaine-induced increases in striatal dopamine levels and cocaine-induced place preference in C57BL/6J mice. Psychopharmacology. 173: 146-52. PMID 14712342 DOI: 10.1007/S00213-003-1716-3  0.461
2004 Zhang Y, Butelman ER, Schlussman SD, Ho A, Kreek MJ. Effect of the endogenous kappa opioid agonist dynorphin A(1-17) on cocaine-evoked increases in striatal dopamine levels and cocaine-induced place preference in C57BL/6J mice. Psychopharmacology. 172: 422-9. PMID 14712335 DOI: 10.1007/S00213-003-1688-3  0.481
2004 Butelman ER, Ball JW, Kreek MJ. Peripheral selectivity and apparent efficacy of dynorphins: comparison to non-peptidic kappa-opioid agonists in rhesus monkeys. Psychoneuroendocrinology. 29: 307-26. PMID 14644063 DOI: 10.1016/S0306-4530(03)00030-1  0.373
2004 Butelman ER, Harris TJ, Kreek MJ. The plant-derived hallucinogen, salvinorin A, produces kappa-opioid agonist-like discriminative effects in rhesus monkeys. Psychopharmacology. 172: 220-4. PMID 14586540 DOI: 10.1007/S00213-003-1638-0  0.376
2003 Zhang Y, Schlussman SD, Ho A, Kreek MJ. Effect of chronic "binge cocaine" on basal levels and cocaine-induced increases of dopamine in the caudate putamen and nucleus accumbens of C57BL/6J and 129/J mice. Synapse (New York, N.Y.). 50: 191-9. PMID 14515336 DOI: 10.1002/Syn.10251  0.434
2003 Mantsch JR, Yuferov V, Mathieu-Kia AM, Ho A, Kreek MJ. Neuroendocrine alterations in a high-dose, extended-access rat self-administration model of escalating cocaine use. Psychoneuroendocrinology. 28: 836-62. PMID 12892653 DOI: 10.1016/S0306-4530(02)00088-4  0.718
2003 Sinha R, Talih M, Malison R, Cooney N, Anderson GM, Kreek MJ. Hypothalamic-pituitary-adrenal axis and sympatho-adreno-medullary responses during stress-induced and drug cue-induced cocaine craving states. Psychopharmacology. 170: 62-72. PMID 12845411 DOI: 10.1007/S00213-003-1525-8  0.422
2003 Butelman ER, Ball JW, Harris TJ, Kreek MJ. Topical capsaicin-induced allodynia in unanesthetized primates: pharmacological modulation. The Journal of Pharmacology and Experimental Therapeutics. 306: 1106-14. PMID 12829725 DOI: 10.1124/Jpet.103.052381  0.336
2003 Zhou Y, Spangler R, Ho A, Kreek MJ. Increased CRH mRNA levels in the rat amygdala during short-term withdrawal from chronic 'binge' cocaine. Brain Research. Molecular Brain Research. 114: 73-9. PMID 12782395 DOI: 10.1016/S0169-328X(03)00139-6  0.44
2003 Schlussman SD, Zhang Y, Kane S, Stewart CL, Ho A, Kreek MJ. Locomotion, stereotypy, and dopamine D1 receptors after chronic "binge" cocaine in C57BL/6J and 129/J mice. Pharmacology, Biochemistry, and Behavior. 75: 123-31. PMID 12759120 DOI: 10.1016/S0091-3057(03)00067-4  0.434
2003 Bart G, Borg L, Schluger JH, Green M, Ho A, Kreek MJ. Suppressed prolactin response to dynorphin A1-13 in methadone-maintained versus control subjects. The Journal of Pharmacology and Experimental Therapeutics. 306: 581-7. PMID 12730354 DOI: 10.1124/Jpet.103.050682  0.372
2003 Schluger JH, Bart G, Green M, Ho A, Kreek MJ. Corticotropin-releasing factor testing reveals a dose-dependent difference in methadone maintained vs control subjects. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 985-94. PMID 12700714 DOI: 10.1038/Sj.Npp.1300156  0.336
2003 Yuferov V, Kroslak T, Laforge KS, Zhou Y, Ho A, Kreek MJ. Differential gene expression in the rat caudate putamen after "binge" cocaine administration: advantage of triplicate microarray analysis. Synapse (New York, N.Y.). 48: 157-69. PMID 12687634 DOI: 10.1002/Syn.10198  0.421
2003 Proudnikov D, Yuferov V, LaForge KS, Ho A, Kreek MJ. Quantification of multiple mRNA levels in rat brain regions using real time optical PCR Molecular Brain Research. 112: 182-185. PMID 12670717 DOI: 10.1016/S0169-328X(03)00056-1  0.318
2003 Kellogg SH, McHugh PF, Bell K, Schluger JH, Schluger RP, LaForge KS, Ho A, Kreek MJ. The Kreek-McHugh-Schluger-Kellogg scale: a new, rapid method for quantifying substance abuse and its possible applications. Drug and Alcohol Dependence. 69: 137-50. PMID 12609695 DOI: 10.1016/S0376-8716(02)00308-3  0.36
2003 Kakko J, Svanborg KD, Kreek MJ, Heilig M. 1-year retention and social function after buprenorphine-assisted relapse prevention treatment for heroin dependence in Sweden: a randomised, placebo-controlled trial. Lancet. 361: 662-8. PMID 12606177 DOI: 10.1016/S0140-6736(03)12600-1  0.322
2003 Proudnikov D, Yuferov V, Zhou Y, LaForge KS, Ho A, Kreek MJ. Optimizing primer--probe design for fluorescent PCR. Journal of Neuroscience Methods. 123: 31-45. PMID 12581847 DOI: 10.1016/S0165-0270(02)00325-4  0.306
2003 Zhou Y, Spangler R, Schlussman SD, Ho A, Kreek MJ. Alterations in hypothalamic-pituitary-adrenal axis activity and in levels of proopiomelanocortin and corticotropin-releasing hormone-receptor 1 mRNAs in the pituitary and hypothalamus of the rat during chronic 'binge' cocaine and withdrawal. Brain Research. 964: 187-99. PMID 12576179 DOI: 10.1016/S0006-8993(02)03929-X  0.433
2003 Kruzich PJ, Chen AC, Unterwald EM, Kreek MJ. Subject-regulated dosing alters morphine self-administration behavior and morphine-stimulated [35S]GTPgammaS binding. Synapse (New York, N.Y.). 47: 243-9. PMID 12539196 DOI: 10.1002/Syn.10173  0.373
2003 LaForge KS, Yuferov V, Zhou Y, Ho A, Nyberg F, Kreek MJ. Binge cocaine differentially alters preproenkephalin mRNA levels in guinea pig brain Brain Research Bulletin. 59: 353-357. PMID 12507685 DOI: 10.1016/S0361-9230(02)00927-9  0.409
2002 Butelman ER, Ball JW, Kreek MJ. Comparison of the discriminative and neuroendocrine effects of centrally penetrating kappa-opioid agonists in rhesus monkeys. Psychopharmacology. 164: 115-20. PMID 12373425 DOI: 10.1007/S00213-002-1195-Y  0.388
2002 Kreek MJ, Vocci FJ. History and current status of opioid maintenance treatments: blending conference session. Journal of Substance Abuse Treatment. 23: 93-105. PMID 12220607 DOI: 10.1016/S0740-5472(02)00259-3  0.393
2002 Kreek MJ, LaForge KS, Butelman E. Pharmacotherapy of addictions. Nature Reviews. Drug Discovery. 1: 710-26. PMID 12209151 DOI: 10.1038/Nrd897  0.366
2002 Zhang Y, Mantsch JR, Schlussman SD, Ho A, Kreek MJ. Conditioned place preference after single doses or "binge" cocaine in C57BL/6J and 129/J mice. Pharmacology, Biochemistry, and Behavior. 73: 655-62. PMID 12151041 DOI: 10.1016/S0091-3057(02)00859-6  0.71
2002 Zhou Y, Spangler R, Schlussman SD, Yuferov VP, Sora I, Ho A, Uhl GR, Kreek MJ. Effects of acute "binge" cocaine on preprodynorphin, preproenkephalin, proopiomelanocortin, and corticotropin-releasing hormone receptor mRNA levels in the striatum and hypothalamic-pituitary-adrenal axis of mu-opioid receptor knockout mice. Synapse (New York, N.Y.). 45: 220-9. PMID 12125043 DOI: 10.1002/Syn.10101  0.464
2002 Borg L, Ho A, Wells A, Joseph H, Appel P, Moody D, Kreek MJ. The use of levo-alpha-acetylmethadol (LAAM) in methadone patients who have not achieved heroin abstinence. Journal of Addictive Diseases. 21: 13-22. PMID 12094997 DOI: 10.1300/J069V21N03_02  0.396
2002 Schlussman SD, Nyberg F, Kreek MJ. The effects of drug abuse on the stress responsive hypothalamic-pituitary-adrenal axis and the dopaminergic and endogenous opioid systems. Acta Psychiatrica Scandinavica. Supplementum. 121-4. PMID 12072142 DOI: 10.1034/J.1600-0447.106.S412.26.X  0.398
2002 King AC, Schluger J, Gunduz M, Borg L, Perret G, Ho A, Kreek MJ. Hypothalamic-pituitary-adrenocortical (HPA) axis response and biotransformation of oral naltrexone: preliminary examination of relationship to family history of alcoholism. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 26: 778-88. PMID 12007748 DOI: 10.1016/S0893-133X(01)00416-X  0.332
2002 Chen AC, LaForge KS, Ho A, McHugh PF, Kellogg S, Bell K, Schluger RP, Leal SM, Kreek MJ. Potentially functional polymorphism in the promoter region of prodynorphin gene may be associated with protection against cocaine dependence or abuse. American Journal of Medical Genetics. 114: 429-35. PMID 11992566 DOI: 10.1002/Ajmg.10362  0.452
2002 Kreek MJ, LaForge KS, Butelman E. Correction: Pharmacotherapy of addictions Nature Reviews Drug Discovery. 1: 926-926. DOI: 10.1038/Nrd968  0.445
2002 Kreek MJ, Borg L, Zhou Y, Schluger J. Relationships between Endocrine Functions and Substance Abuse Syndromes: Heroin and Related Short-Acting Opiates in Addiction Contrasted with Methadone and Other Long-Acting Opioid Agonists Used in Pharmacotherapy of Addiction Hormones, Brain and Behavior. 781-830. DOI: 10.1016/B978-012532104-4/50108-6  0.404
2001 Zhang Y, Schlussman SD, Ho A, Kreek MJ. Effect of acute binge cocaine on levels of extracellular dopamine in the caudate putamen and nucleus accumbens in male C57BL/6J and 129/J mice. Brain Research. 923: 172-7. PMID 11743985 DOI: 10.1016/S0006-8993(01)03032-3  0.383
2001 Zhou Y, Spangler R, Ho A, Kreek MJ. Hypothalamic CRH mRNA levels are differentially modulated by repeated ‘binge’ cocaine with or without D1 dopamine receptor blockade Molecular Brain Research. 94: 112-118. PMID 11597771 DOI: 10.1016/S0169-328X(01)00223-6  0.429
2001 Zhou Y, Unterwald EM, Ho A, LaForge KS, Yuferov VP, Kreuter J, Sirianni MJ, Allen RG, Kreek MJ. Ablation of pituitary pro-opiomelanocortin (POMC) cells produces alterations in hypothalamic POMC mRNA levels and midbrain mu opioid receptor binding in a conditional transgenic mouse model. Journal of Neuroendocrinology. 13: 808-17. PMID 11578531 DOI: 10.1046/J.1365-2826.2001.00702.X  0.398
2001 Mantsch JR, Ho A, Schlussman SD, Kreek MJ. Predictable individual differences in the initiation of cocaine self-administration by rats under extended-access conditions are dose-dependent. Psychopharmacology. 157: 31-9. PMID 11512040 DOI: 10.1007/S002130100744  0.714
2001 Cigler T, LaForge KS, McHugh PF, Kapadia SU, Leal SM, Kreek MJ. Novel and previously reported single-nucleotide polymorphisms in the human 5-HT(1B) receptor gene: no association with cocaine or alcohol abuse or dependence. American Journal of Medical Genetics. 105: 489-97. PMID 11496363 DOI: 10.1002/Ajmg.1473  0.396
2001 Kreek MJ. Drug addictions. Molecular and cellular endpoints. Annals of the New York Academy of Sciences. 937: 27-49. PMID 11458539 DOI: 10.1111/J.1749-6632.2001.Tb03557.X  0.339
2001 Butelman ER, Kreek MJ. kappa-Opioid receptor agonist-induced prolactin release in primates is blocked by dopamine D(2)-like receptor agonists. European Journal of Pharmacology. 423: 243-9. PMID 11448491 DOI: 10.1016/S0014-2999(01)01121-9  0.402
2001 Yuferov V, Zhou Y, LaForge KS, Spangler R, Ho A, Kreek MJ. Elevation of guinea pig brain preprodynorphin mRNA expression and hypothalamic-pituitary-adrenal axis activity by "binge" pattern cocaine administration. Brain Research Bulletin. 55: 65-70. PMID 11427339 DOI: 10.1016/S0361-9230(01)00496-8  0.449
2001 Unterwald EM, Kreek MJ, Cuntapay M. The frequency of cocaine administration impacts cocaine-induced receptor alterations. Brain Research. 900: 103-9. PMID 11325352 DOI: 10.1016/S0006-8993(01)02269-7  0.472
2001 Schluger JH, Borg L, Ho A, Kreek MJ. Altered HPA axis responsivity to metyrapone testing in methadone maintained former heroin addicts with ongoing cocaine addiction. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 24: 568-75. PMID 11282257 DOI: 10.1016/S0893-133X(00)00222-0  0.434
2001 Mathieu-Kia AM, Fan LQ, Kreek MJ, Simon EJ, Hiller JM. Mu-, delta- and kappa-opioid receptor populations are differentially altered in distinct areas of postmortem brains of Alzheimer's disease patients. Brain Research. 893: 121-34. PMID 11223000 DOI: 10.1016/S0006-8993(00)03302-3  0.388
2001 Jacobsen LK, Giedd JN, Kreek MJ, Gottschalk C, Kosten TR. Quantitative medial temporal lobe brain morphology and hypothalamic-pituitary-adrenal axis function in cocaine dependence: a preliminary report. Drug and Alcohol Dependence. 62: 49-56. PMID 11173167 DOI: 10.1016/S0376-8716(00)00159-9  0.412
2000 Quiñones-Jenab V, Perrotti LI, Mc Monagle J, Ho A, Kreek MJ. Ovarian hormone replacement affects cocaine-induced behaviors in ovariectomized female rats. Pharmacology, Biochemistry, and Behavior. 67: 417-22. PMID 11164068 DOI: 10.1016/S0091-3057(00)00381-6  0.422
2000 LaForge KS, Yuferov V, Kreek MJ. Opioid receptor and peptide gene polymorphisms: potential implications for addictions. European Journal of Pharmacology. 410: 249-268. PMID 11134674 DOI: 10.1016/S0014-2999(00)00819-0  0.437
2000 Kling MA, Carson RE, Borg L, Zametkin A, Matochik JA, Schluger J, Herscovitch P, Rice KC, Ho A, Eckelman WC, Kreek MJ. Opioid receptor imaging with positron emission tomography and [(18)F]cyclofoxy in long-term, methadone-treated former heroin addicts. The Journal of Pharmacology and Experimental Therapeutics. 295: 1070-6. PMID 11082442  0.312
2000 LaForge KS, Shick V, Spangler R, Proudnikov D, Yuferov V, Lysov Y, Mirzabekov A, Kreek MJ. Detection of single nucleotide polymorphisms of the human mu opioid receptor gene by hybridization or single nucleotide extension on custom oligonucleotide gelpad microchips: potential in studies of addiction. American Journal of Medical Genetics. 96: 604-15. PMID 11054767 DOI: 10.1002/1096-8628(20001009)96:5<604::Aid-Ajmg5>3.0.Co;2-F  0.373
2000 Zhou Y, Franck J, Spangler R, Maggos CE, Ho A, Kreek MJ. Reduced hypothalamic POMC and anterior pituitary CRF1 receptor mRNA levels after acute, but not chronic, daily "binge" intragastric alcohol administration. Alcoholism, Clinical and Experimental Research. 24: 1575-82. PMID 11045867 DOI: 10.1111/J.1530-0277.2000.Tb04577.X  0.306
2000 Kreek MJ. Methadone-related opioid agonist pharmacotherapy for heroin addiction. History, recent molecular and neurochemical research and future in mainstream medicine. Annals of the New York Academy of Sciences. 909: 186-216. PMID 10911931 DOI: 10.1111/J.1749-6632.2000.Tb06683.X  0.467
2000 Quiñones-Jenab V, Perrotti LI, Ho A, Jenab S, Schlussman SD, Franck J, Kreek MJ. Cocaine affects progesterone plasma levels in female rats. Pharmacology, Biochemistry, and Behavior. 66: 449-53. PMID 10880704 DOI: 10.1016/S0091-3057(00)00213-6  0.416
2000 Mantsch JR, Schlussman SD, Ho A, Kreek MJ. Effects of cocaine self-administration on plasma corticosterone and prolactin in rats. The Journal of Pharmacology and Experimental Therapeutics. 294: 239-47. PMID 10871318  0.688
2000 Schlussman SD, Zhou Y, Johansson P, Kiuru A, Ho A, Nyberg F, Kreek MJ. Effects of the androgenic anabolic steroid, nandrolone decanoate, on adrenocorticotropin hormone, corticosterone and proopiomelanocortin, corticotropin releasing factor (CRF) and CRF receptor1 mRNA levels in the hypothalamus, pituitary and amygdala of the rat. Neuroscience Letters. 284: 190-4. PMID 10773431 DOI: 10.1016/S0304-3940(00)01016-8  0.318
2000 Quiñones-Jenab V, Krey LC, Schlussman SD, Ho A, Kreek MJ. Chronic 'binge' pattern cocaine alters the neuroendocrine profile of pregnant rats. Neuroscience Letters. 282: 120-2. PMID 10713411 DOI: 10.1016/S0304-3940(00)00869-7  0.405
2000 Farren CK, O’Malley S, Tilton R, Kreek MJ. 460. Opioid abnormalities in alcoholism: naltrexone induced responses Biological Psychiatry. 47. DOI: 10.1016/S0006-3223(00)00730-7  0.347
1999 Borg L, Broe DM, Ho A, Kreek MJ. Cocaine abuse sharply reduced in an effective methadone maintenance program. Journal of Addictive Diseases. 18: 63-75. PMID 10631964 DOI: 10.1300/J069V18N04_06  0.472
1999 Butelman ER, Harris TJ, Kreek MJ. Apparent efficacy of κ-opioid receptor ligands on serum prolactin levels in rhesus monkeys European Journal of Pharmacology. 383: 305-309. PMID 10594324 DOI: 10.1016/S0014-2999(99)00640-8  0.378
1999 Butelman ER, Harris TJ, Kreek MJ. Effects of E-2078, a stable dynorphin A(1-8) analog, on sedation and serum prolactin levels in rhesus monkeys. Psychopharmacology. 147: 73-80. PMID 10591871 DOI: 10.1007/S002130051144  0.376
1999 Zhou Y, Spangler R, Maggos CE, Wang XM, Han JS, Ho A, Kreek MJ. Hypothalamic-pituitary-adrenal activity and pro-opiomelanocortin mRNA levels in the hypothalamus and pituitary of the rat are differentially modulated by acute intermittent morphine with or without water restriction stress. The Journal of Endocrinology. 163: 261-7. PMID 10556776 DOI: 10.1677/Joe.0.1630261  0.35
1999 Zhou Y, Schlussman SD, Ho A, Spangler R, Fienberg AA, Greengard P, Kreek MJ. Effects of chronic 'Binge' cocaine administration on plasma ACTH and corticosterone levels in mice deficient in DARPP-32. Neuroendocrinology. 70: 196-9. PMID 10516482 DOI: 10.1159/000054476  0.444
1999 Rosen MI, Kosten TR, Kreek MJ. The effects of naltrexone maintenance on the response to yohimbine in healthy volunteers. Biological Psychiatry. 45: 1636-45. PMID 10376126 DOI: 10.1016/S0006-3223(98)00259-5  0.345
1999 Quiñones-Jenab V, Ho A, Schlussman SD, Franck J, Kreek MJ. Estrous cycle differences in cocaine-induced stereotypic and locomotor behaviors in Fischer rats. Behavioural Brain Research. 101: 15-20. PMID 10342395 DOI: 10.1016/S0166-4328(98)00073-4  0.425
1999 Butelman ER, Vivian JA, Yu J, Kreek MJ, Woods JH. Systemic effects of E-2078, a stabilized dynorphin A(1-8) analog, in rhesus monkeys. Psychopharmacology. 143: 190-6. PMID 10326782 DOI: 10.1007/S002130050935  0.364
1999 Yuferov V, Zhou Y, Spangler R, Maggos CE, Ho A, Kreek MJ. Acute "binge" cocaine increases mu-opioid receptor mRNA levels in areas of the rat mesolimbic mesocortical dopamine system. Brain Research Bulletin. 48: 109-12. PMID 10210176 DOI: 10.1016/S0361-9230(98)00155-5  0.497
1999 King AC, Ho A, Schluger J, Borg L, Kreek MJ. Acute subjective effects of dynorphin A(1-13) infusion in normal healthy subjects. Drug and Alcohol Dependence. 54: 87-90. PMID 10101621 DOI: 10.1016/S0376-8716(98)00150-1  0.338
1999 Wang XM, Zhou Y, Spangler R, Ho A, Han JS, Kreek MJ. Acute intermittent morphine increases preprodynorphin and kappa opioid receptor mRNA levels in the rat brain. Brain Research. Molecular Brain Research. 66: 184-7. PMID 10095091 DOI: 10.1016/S0169-328X(99)00021-2  0.399
1999 Kreek MJ, Schluger J, Borg L, Gunduz M, Ho A. Dynorphin A1-13 causes elevation of serum levels of prolactin through an opioid receptor mechanism in humans: gender differences and implications for modulation of dopaminergic tone in the treatment of addictions. The Journal of Pharmacology and Experimental Therapeutics. 288: 260-9. PMID 9862779  0.381
1999 Portenoy RK, Caraceni A, Cherny NI, Goldblum R, Ingham J, Inturrisi CE, Johnson JH, Lapin J, Tiseo PJ, Kreek MJ. Dynorphin A(1-13) analgesia in opioid-treated patients with chronic pain. A controlled pilot study Clinical Drug Investigation. 17: 33-42. DOI: 10.2165/00044011-199917010-00004  0.351
1998 Sarnyai Z, Dhabhar FS, McEwen BS, Kreek MJ. Neuroendocrine-related effects of long-term, 'binge' cocaine administration: diminished individual differences in stress-induced corticosterone response. Neuroendocrinology. 68: 334-44. PMID 9822801 DOI: 10.1159/000054382  0.422
1998 Schluger JH, Ho A, Borg L, Porter M, Maniar S, Gunduz M, Perret G, King A, Kreek MJ. Nalmefene causes greater hypothalamic-pituitary-adrenal axis activation than naloxone in normal volunteers: implications for the treatment of alcoholism. Alcoholism, Clinical and Experimental Research. 22: 1430-6. PMID 9802524 DOI: 10.1111/J.1530-0277.1998.Tb03931.X  0.43
1998 Sarnyai Z, McKittrick CR, McEwen BS, Kreek MJ. Selective regulation of dopamine transporter binding in the shell of the nucleus accumbens by adrenalectomy and corticosterone-replacement. Synapse (New York, N.Y.). 30: 334-7. PMID 9776137 DOI: 10.1002/(Sici)1098-2396(199811)30:3<334::Aid-Syn11>3.0.Co;2-#  0.326
1998 Perret G, Schluger JH, Unterwald EM, Kreuter J, Ho A, Kreek MJ. Downregulation of 5-HT1A receptors in rat hypothalamus and dentate gyrus after "binge" pattern cocaine administration. Synapse (New York, N.Y.). 30: 166-71. PMID 9723786 DOI: 10.1002/(Sici)1098-2396(199810)30:2<166::Aid-Syn6>3.0.Co;2-A  0.442
1998 Zhou Y, Yuferov VP, Spangler R, Maggos CE, Ho A, Kreek MJ. Effects of memantine alone and with acute 'binge' cocaine on hypothalamic-pituitary-adrenal activity in the rat. European Journal of Pharmacology. 352: 65-71. PMID 9718269 DOI: 10.1016/S0014-2999(98)00332-X  0.433
1998 Kreek MJ, Koob GF. Drug dependence: stress and dysregulation of brain reward pathways. Drug and Alcohol Dependence. 51: 23-47. PMID 9716928 DOI: 10.1016/S0376-8716(98)00064-7  0.333
1998 Bond C, LaForge KS, Tian M, Melia D, Zhang S, Borg L, Gong J, Schluger J, Strong JA, Leal SM, Tischfield JA, Kreek MJ, Yu L. Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction. Proceedings of the National Academy of Sciences of the United States of America. 95: 9608-13. PMID 9689128 DOI: 10.1073/Pnas.95.16.9608  0.437
1998 Specker S, Wananukul W, Hatsukami D, Nolin K, Hooke L, Kreek MJ, Pentel PR. Effects of dynorphin A(1-13) on opiate withdrawal in humans. Psychopharmacology. 137: 326-32. PMID 9676891 DOI: 10.1007/S002130050626  0.321
1998 Maggos CE, Tsukada H, Kakiuchi T, Nishiyama S, Myers JE, Kreuter J, Schlussman SD, Unterwald EM, Ho A, Kreek MJ. Sustained withdrawal allows normalization of in vivo [11C]N-methylspiperone dopamine D2 receptor binding after chronic binge cocaine: a positron emission tomography study in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 19: 146-53. PMID 9629568 DOI: 10.1016/S0893-133X(98)00009-8  0.388
1997 Unterwald EM, Tsukada H, Kakiuchi T, Kosugi T, Nishiyama S, Kreek MJ. Use of positron emission tomography to measure the effects of nalmefene on D1 and D2 dopamine receptors in rat brain. Brain Research. 775: 183-8. PMID 9439841 DOI: 10.1016/S0006-8993(97)00931-1  0.337
1997 Quiñones-Jenab V, Batel P, Schlussman SD, Ho A, Kreek MJ. Cocaine impairs maternal nest building in pregnant rats. Pharmacology, Biochemistry, and Behavior. 58: 1009-13. PMID 9408207 DOI: 10.1016/S0091-3057(97)00311-0  0.411
1997 Lucas LR, Schlussman SD, Ho A, McEwen BS, Kreek MJ. Novelty-induced locomoter activity in Long-Evans rats pre- and post-chronic 'binge'-pattern cocaine treatment. Neuroscience Letters. 237: 25-8. PMID 9406871 DOI: 10.1016/S0304-3940(97)00799-4  0.415
1997 Bergasa NV, Mohajer B, Maisonneuve IM, Ho A, Maidment NT, Olive F, Gunduz M, Kreek MJ. Basal total opioid peptide release in the striatum of rats with cholestasis from bile duct resection: a study by the use of in vivo microdialysis. Life Sciences. 61: 1169-75. PMID 9315507 DOI: 10.1016/S0024-3205(97)00658-9  0.362
1997 King AC, Volpicelli JR, Gunduz M, O'Brien CP, Kreek MJ. Naltrexone biotransformation and incidence of subjective side effects: a preliminary study. Alcoholism, Clinical and Experimental Research. 21: 906-9. PMID 9267542 DOI: 10.1111/J.1530-0277.1997.Tb03856.X  0.337
1997 Kreek MJ. Opiate and cocaine addictions: challenge for pharmacotherapies. Pharmacology, Biochemistry, and Behavior. 57: 551-69. PMID 9218280 DOI: 10.1016/S0091-3057(96)00440-6  0.42
1997 Spangler R, Zhou Y, Schlussman SD, Ho A, Kreek MJ. Behavioral stereotypies induced by "binge' cocaine administration are independent of drug-induced increases in corticosterone levels. Behavioural Brain Research. 86: 201-4. PMID 9134155 DOI: 10.1016/S0166-4328(96)02257-7  0.449
1997 Maggos CE, Spangler R, Zhou Y, Schlussman SD, Ho A, Kreek MJ. Quantitation of dopamine transporter mRNA in the rat brain: mapping, effects of "binge" cocaine administration and withdrawal. Synapse (New York, N.Y.). 26: 55-61. PMID 9097405 DOI: 10.1002/(Sici)1098-2396(199705)26:1<55::Aid-Syn6>3.0.Co;2-D  0.378
1997 Culpepper-Morgan JA, Kreek MJ. Hypothalamic-pituitary-adrenal axis hypersensitivity to naloxone in opioid dependence: a case of naloxone-induced withdrawal. Metabolism: Clinical and Experimental. 46: 130-4. PMID 9030816 DOI: 10.1016/S0026-0495(97)90289-4  0.399
1997 Spangler R, Zhou Y, Maggos CE, Schlussman SD, Ho A, Kreek MJ. Prodynorphin, proenkephalin and kappa opioid receptor mRNA responses to acute "binge" cocaine. Brain Research. Molecular Brain Research. 44: 139-42. PMID 9030708 DOI: 10.1016/S0169-328X(96)00249-5  0.442
1997 Kreek MJ. Clinical Update of Opioid Agonist and Partial Agonist Medications for the Maintenance Treatment of Opioid Addiction Seminars in Neuroscience. 9: 140-157. DOI: 10.1006/Smns.1997.0114  0.432
1996 Kreek MJ. Opiates, opioids and addiction. Molecular Psychiatry. 1: 232-54. PMID 9118348  0.311
1996 Unterwald EM, Fillmore J, Kreek MJ. Chronic repeated cocaine administration increases dopamine D1 receptor-mediated signal transduction. European Journal of Pharmacology. 318: 31-5. PMID 9007509 DOI: 10.1016/S0014-2999(96)00841-2  0.429
1996 Peters JE, Chou JZ, Ho A, Reid K, Borg L, Kreek MJ. Simplified quantitation of urinary benzoylecgonine in cocaine addiction research and for related pharmacotherapeutic trials. Addiction (Abingdon, England). 91: 1687-97. PMID 8972926 DOI: 10.1046/J.1360-0443.1996.911116879.X  0.408
1996 Zhou Y, Spangler R, Maggos CE, LaForge KS, Ho A, Kreek MJ. Steady-state methadone in rats does not change mRNA levels of corticotropin-releasing factor, its pituitary receptor or proopiomelanocortin. European Journal of Pharmacology. 315: 31-5. PMID 8960861 DOI: 10.1016/S0014-2999(96)00672-3  0.381
1996 Kreek MJ. Opioid receptors: some perspectives from early studies of their role in normal physiology, stress responsivity, and in specific addictive diseases. Neurochemical Research. 21: 1469-88. PMID 8947936 DOI: 10.1007/Bf02532387  0.47
1996 Kreek MJ. Cocaine, dopamine and the endogenous opioid system. Journal of Addictive Diseases. 15: 73-96. PMID 8943583 DOI: 10.1300/J069V15N04_05  0.458
1996 Spangler R, Zhou Y, Maggos CE, Zlobin A, Ho A, Kreek MJ. Dopamine antagonist and "binge' cocaine effects on rat opioid and dopamine transporter mRNAs. Neuroreport. 7: 2196-200. PMID 8930988 DOI: 10.1097/00001756-199609020-00028  0.441
1996 Tsukada H, Kreuter J, Maggos CE, Unterwald EM, Kakiuchi T, Nishiyama S, Futatsubashi M, Kreek MJ. Effects of binge pattern cocaine administration on dopamine D1 and D2 receptors in the rat brain: an in vivo study using positron emission tomography. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 7670-7. PMID 8922423 DOI: 10.1523/Jneurosci.16-23-07670.1996  0.394
1996 Zhou Y, Spangler R, LaForge KS, Maggos CE, Ho A, Kreek MJ. Corticotropin-releasing factor and type 1 corticotropin-releasing factor receptor messenger RNAs in rat brain and pituitary during "binge"-pattern cocaine administration and chronic withdrawal. The Journal of Pharmacology and Experimental Therapeutics. 279: 351-8. PMID 8859013  0.318
1996 Spangler R, Ho A, Zhou Y, Maggos CE, Yuferov V, Kreek MJ. Regulation of kappa opioid receptor mRNA in the rat brain by "binge' pattern cocaine administration and correlation with preprodynorphin mRNA. Brain Research. Molecular Brain Research. 38: 71-6. PMID 8737669 DOI: 10.1016/0169-328X(95)00319-N  0.44
1996 Donovan DM, Miner LL, Sharpe L, Cho HJ, Takemura M, Unterwald E, Nyberg F, Kreek MJ, Uhl GR. Transgenic mice: preproenkephalin and the mu opiate receptor. Annals of the New York Academy of Sciences. 780: 19-28. PMID 8602733 DOI: 10.1111/J.1749-6632.1996.Tb15108.X  0.328
1995 Unterwald EM, Rubenfeld JM, Imai Y, Wang JB, Uhl GR, Kreek MJ. Chronic opioid antagonist administration upregulates mu opioid receptor binding without altering mu opioid receptor mRNA levels. Brain Research. Molecular Brain Research. 33: 351-5. PMID 8750897 DOI: 10.1016/0169-328X(95)00143-G  0.437
1995 Borg L, Ho A, Peters JE, Kreek MJ. Availability of reliable serum methadone determination for management of symptomatic patients. Journal of Addictive Diseases. 14: 83-96. PMID 8555281 DOI: 10.1300/J069V14N03_06  0.343
1995 Culpepper-Morgan JA, Holt PR, LaRoche D, Kreek MJ. Orally administered opioid antagonists reverse both mu and kappa opioid agonist delay of gastrointestinal transit in the guinea pig Life Sciences. 56: 1187-1192. PMID 7475895 DOI: 10.1016/0024-3205(95)00057-D  0.392
1994 Lai Z, Zhai Q, Yukhananov R, Larsson C, Roos P, Kreek MJ, Nyberg F. Effects of morphine on prolactin receptors in the rat brain Febs Letters. 338: 207-211. PMID 8307182 DOI: 10.1016/0014-5793(94)80366-8  0.319
1994 Unterwald EM, Rubenfeld JM, Kreek MJ. Repeated cocaine administration upregulates kappa and mu, but not delta, opioid receptors. Neuroreport. 5: 1613-6. PMID 7819531 DOI: 10.1097/00001756-199408150-00018  0.499
1994 Zhou Y, Spangler R, LaForge KS, Kreek MJ. Attenuation of the hypothalamic-pituitary-adrenal response to chronic “binge” pattern cocaine administration corresponds to decreased CRH mRNA in rat hypothalamus Regulatory Peptides. 54: 345-346. DOI: 10.1016/0167-0115(94)90530-4  0.423
1994 Unterwald EM, Rubenfeld JM, Spangler R, Imai Y, Wang JB, Uhl GR, Kreek MJ. Mu opioid receptor mRNA levels following chronic naltrexone administration Regulatory Peptides. 54: 307-308. DOI: 10.1016/0167-0115(94)90512-6  0.418
1994 Spangler R, Zhou Y, Unterwald E, Yuferov V, Ho A, Kreek MJ. Kappa opioid receptor mRNA levels in the rat brain: Effects of dopamine antagonists and cocaine Regulatory Peptides. 54: 283-284. DOI: 10.1016/0167-0115(94)90500-2  0.468
1994 Kreek MJ. Pharmacotherapy of opioid dependence: Rationale and update Regulatory Peptides. 53. DOI: 10.1016/0167-0115(94)90336-0  0.397
1994 Unterwald E, Kreek MJ. Kappa and delta opioid receptor densities following chronic repeated cocaine administration Regulatory Peptides. 53: S225-S226. DOI: 10.1016/0167-0115(94)90322-0  0.453
1993 Unterwald EM, Cox BM, Kreek MJ, Cote TE, Izenwasser S. Chronic repeated cocaine administration alters basal and opioid-regulated adenylyl cyclase activity. Synapse (New York, N.Y.). 15: 33-8. PMID 8310423 DOI: 10.1002/Syn.890150104  0.497
1993 Spangler R, Unterwald EM, Kreek MJ. 'Binge' cocaine administration induces a sustained increase of prodynorphin mRNA in rat caudate-putamen. Brain Research. Molecular Brain Research. 19: 323-7. PMID 7694032 DOI: 10.1016/0169-328X(93)90133-A  0.42
1993 Culpepper-Morgan JA, Inturisi CE, Portenoy RK, Foley K, Houde RW, Marsh F, Kreek MJ. Treatment of Opioid-Induced Constipation with Oral Naloxone: A Pilot Study Survey of Anesthesiology. 37: 239. DOI: 10.1097/00132586-199308000-00063  0.376
1992 Culpepper‐Morgan JA, Inturrisi CE, Portenoy RK, Foley K, Houde RW, Marsh F, Kreek MJ. Treatment of opioid‐induced constipation with oral naloxone: A pilot study Clinical Pharmacology &Amp; Therapeutics. 52: 90-95. PMID 1623695 DOI: 10.1038/Clpt.1992.106  0.363
1992 Kosten TR, Morgan C, Kreek MJ. Beta endorphin levels during heroin, methadone, buprenorphine, and naloxone challenges: preliminary findings. Biological Psychiatry. 32: 523-8. PMID 1445968 DOI: 10.1016/0006-3223(92)90220-T  0.386
1992 Unterwald EM, Horne-King J, Kreek MJ. Chronic cocaine alters brain mu opioid receptors. Brain Research. 584: 314-8. PMID 1325249 DOI: 10.1016/0006-8993(92)90912-S  0.505
1992 Branch AD, Unterwald EM, Lee SE, Kreek MJ. Quantitation of preproenkephalin mRNA levels in brain regions from male Fischer rats following chronic cocaine treatment using a recently developed solution hybridization assay. Brain Research. Molecular Brain Research. 14: 231-8. PMID 1279343 DOI: 10.1016/0169-328X(92)90178-E  0.355
1991 Tabasco-Minguillan J, Novick DM, Kreek MJ. Liver function tests in non-parenteral cocaine users Nida Research Monograph. 105: 372. PMID 1876045 DOI: 10.1016/0376-8716(90)90124-W  0.403
1990 Kennedy JA, Hartman N, Sbriglio R, Khuri E, Kreek MJ. Metyrapone-induced withdrawal symptoms. Addiction. 85: 1133-1140. PMID 2224193 DOI: 10.1111/J.1360-0443.1990.Tb03438.X  0.358
1987 Novick DM, Senie RT, Kreek MJ, Yancovitz SR. Clinical and demographic features of patients admitted to a new chemical dependency program in New York City Drug and Alcohol Dependence. 20: 271-278. PMID 3436259 DOI: 10.1016/0376-8716(87)90037-8  0.334
1986 Kosten TR, Kreek MJ, Ragunath J, Kleber HD. Cortisol levels during chronic naltrexone maintenance treatment in ex-opiate addicts. Biological Psychiatry. 21: 217-20. PMID 3947698 DOI: 10.1016/0006-3223(86)90150-2  0.371
1986 Novick DM, Stenger RJ, Gelb AM, Most J, Yancovitz SR, Kreek MJ. Chronic liver disease in abusers of alcohol and parenteral drugs: A report of 204 consecutive biopsy-proven cases Alcoholism: Clinical and Experimental Research. 10: 500-505. PMID 3541673 DOI: 10.1111/J.1530-0277.1986.Tb05131.X  0.321
1985 Novick DM, Enlow RW, Gelb AM, Stenger RJ, Fotino M, Winter JW, Yancovitz SR, Schoenberg MD, Kreek MJ. Hepatic cirrhosis in young adults: Association with adolescent onset of alcohol and parenteral heroin abuse Gut. 26: 8-13. PMID 3855296 DOI: 10.1136/Gut.26.1.8  0.301
1984 Kreek MJ. Opioid interactions with alcohol. Advances in Alcohol and Substance Abuse. 3: 35-46. PMID 6391108 DOI: 10.1300/J251V03N04_04  0.421
1983 Hartman N, Kreek MJ, Ross A, Khuri E, Millman RB, Rodriguez R. Alcohol use in youthful methadone-maintained former heroin addicts: Liver impairment and treatment outcome Alcoholism: Clinical and Experimental Research. 7: 316-320. PMID 6353983 DOI: 10.1111/J.1530-0277.1983.Tb05469.X  0.304
1983 Ragavan VV, Wardlaw SL, Kreek MJ, Frantz AG. Effect of chronic naltrexone and methadone administration on brain immunoreactive beta-endorphin in the rat. Neuroendocrinology. 37: 266-8. PMID 6314167 DOI: 10.1159/000123556  0.302
1983 Kreek M, Hahn E, Schaefer R, Fishman J. Naloxone, A Specific Opioid Antagonist, Reverses Chronic Idiopathic Constipation The Lancet. 321: 261-262. PMID 6130292 DOI: 10.1016/S0140-6736(83)91684-7  0.41
1982 Kreek MJ, Hartman N. Chronic Use Of Opioids And Antipsychotic Drugs: Side Effects, Effects On Endogenous Opioids, And Toxicity * Annals of the New York Academy of Sciences. 398: 151-172. PMID 6130734 DOI: 10.1111/J.1749-6632.1982.Tb39489.X  0.411
1982 Kreek MJ. Opioid Disposition and Effects During Chronic Exposure in the Perinatal Period in Man Advances in Alcohol and Substance Abuse. 1: 21-53. DOI: 10.1300/J251V01N03_03  0.434
1981 Tong TG, Pond SM, Kreek MJ, Jaffery NF, Benowitz NL. Phenytoin-Induced Methadone Withdrawal Annals of Internal Medicine. 94: 349-351. PMID 7224382 DOI: 10.7326/0003-4819-94-3-349  0.317
1981 Kreek MJ. Metabolic Interactions Between Opiates And Alcohol Annals of the New York Academy of Sciences. 362: 36-49. PMID 6942711 DOI: 10.1111/J.1749-6632.1981.Tb12789.X  0.302
1980 Tong TG, Benowitz NL, Kreek MJ. Methadone—Disulfiram Interaction During Methadone Maintenance The Journal of Clinical Pharmacology. 20: 506-513. PMID 7430415 DOI: 10.1002/J.1552-4604.1980.Tb02543.X  0.331
1976 Kreek MJ, Garfield JW, Gutjahr CL, Giusti LM. Rifampin-induced methadone withdrawal. The New England Journal of Medicine. 294: 1104-6. PMID 1256526 DOI: 10.1056/Nejm197605132942008  0.303
1973 Dole VP, Kreek MJ. Methadone plasma level: sustained by a reservoir of drug in tissue. Proceedings of the National Academy of Sciences of the United States of America. 70: 10. PMID 4509643 DOI: 10.1073/Pnas.70.1.10  0.3
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