Prescott Tarn Leach - Publications

Affiliations: 
Temple University, Philadelphia, PA, United States 

16 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Leach PT, Kenney JW, Gould TJ. c-Jun-N-Terminal Kinase 1 (JNK1) is Necessary for Nicotine-Induced Enhancement of Contextual Fear Conditioning. Neuroscience Letters. PMID 27235579 DOI: 10.1016/J.Neulet.2016.05.048  1
2016 Mandal M, Wu Y, Misiaszek J, Li G, Buevich AV, Caldwell JP, Liu X, Mazzola RD, Orth P, Strickland C, Voigt JH, Wang H, Zhu Z, Chen X, Grzelak M, ... ... Leach PT, et al. Structure-Based Design of an Iminoheterocyclic beta-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in non-Human Primates. Journal of Medicinal Chemistry. PMID 26937601 DOI: 10.1021/acs.jmedchem.5b01995  1
2015 Leach PT, Gould TJ. Thyroid hormone signaling: Contribution to neural function, cognition, and relationship to nicotine. Neuroscience and Biobehavioral Reviews. PMID 26344666 DOI: 10.1016/J.Neubiorev.2015.09.001  1
2015 Leach PT, Kenney JW, Connor DA, Gould TJ. Thyroid receptor β involvement in the effects of acute nicotine on hippocampus-dependent memory. Neuropharmacology. 93: 155-63. PMID 25666034 DOI: 10.1016/J.Neuropharm.2015.01.026  1
2015 Leach PT, Kenney JW, Gould TJ. Stronger learning recruits additional cell-signaling cascades: c-Jun-N-terminal kinase 1 (JNK1) is necessary for expression of stronger contextual fear conditioning. Neurobiology of Learning and Memory. 118: 162-6. PMID 25543025 DOI: 10.1016/J.Nlm.2014.12.008  1
2015 Leach PT, Holliday E, Kutlu MG, Gould TJ. Withdrawal From Chronic Nicotine Reduces Thyroid Hormone Levels and Levothyroxine Treatment Ameliorates Nicotine Withdrawal-Induced Deficits in Hippocampus-Dependent Learning in C57BL/6J Mice. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 17: 690-6. PMID 25358661 DOI: 10.1093/Ntr/Ntu229  1
2014 Gould TJ, Wilkinson DS, Yildirim E, Poole RL, Leach PT, Simmons SJ. Nicotine shifts the temporal activation of hippocampal protein kinase A and extracellular signal-regulated kinase 1/2 to enhance long-term, but not short-term, hippocampus-dependent memory. Neurobiology of Learning and Memory. 109: 151-9. PMID 24457151 DOI: 10.1016/J.Nlm.2014.01.009  1
2014 Gould TJ, Leach PT. Cellular, molecular, and genetic substrates underlying the impact of nicotine on learning. Neurobiology of Learning and Memory. 107: 108-32. PMID 23973448 DOI: 10.1016/J.Nlm.2013.08.004  1
2013 Lotfipour S, Byun JS, Leach P, Fowler CD, Murphy NP, Kenny PJ, Gould TJ, Boulter J. Targeted deletion of the mouse α2 nicotinic acetylcholine receptor subunit gene (Chrna2) potentiates nicotine-modulated behaviors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 7728-41. PMID 23637165 DOI: 10.1523/Jneurosci.4731-12.2013  1
2013 Hyde LA, Zhang Q, Del Vecchio RA, Leach PT, Cohen-Williams ME, Chen L, Wong GT, McHugh NA, Chen J, Higgins GA, Asberom T, Li W, Pissarnitski D, Levitan D, Nomeir AA, et al. In Vivo Characterization of a Novel γ-Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects. International Journal of Alzheimer's Disease. 2013: 823528. PMID 23573456 DOI: 10.1155/2013/823528  1
2013 Leach PT, Cordero KA, Gould TJ. The effects of acute nicotine, chronic nicotine, and withdrawal from chronic nicotine on performance of a cued appetitive response. Behavioral Neuroscience. 127: 303-10. PMID 23565938 DOI: 10.1037/A0031913  1
2012 Mandal M, Zhu Z, Cumming JN, Liu X, Strickland C, Mazzola RD, Caldwell JP, Leach P, Grzelak M, Hyde L, Zhang Q, Terracina G, Zhang L, Chen X, Kuvelkar R, et al. Design and validation of bicyclic iminopyrimidinones as beta amyloid cleaving enzyme-1 (BACE1) inhibitors: conformational constraint to favor a bioactive conformation. Journal of Medicinal Chemistry. 55: 9331-45. PMID 22989333 DOI: 10.1021/Jm301039C  1
2012 Leach PT, Poplawski SG, Kenney JW, Hoffman B, Liebermann DA, Abel T, Gould TJ. Gadd45b knockout mice exhibit selective deficits in hippocampus-dependent long-term memory. Learning & Memory (Cold Spring Harbor, N.Y.). 19: 319-24. PMID 22802593 DOI: 10.1101/Lm.024984.111  1
2011 André JM, Leach PT, Gould TJ. Nicotine ameliorates NMDA receptor antagonist-induced deficits in contextual fear conditioning through high-affinity nicotinic acetylcholine receptors in the hippocampus. Neuropharmacology. 60: 617-25. PMID 21167848 DOI: 10.1016/J.Neuropharm.2010.12.004  1
2011 Hodgson RA, Hyde LA, Guthrie DH, Cohen-Williams ME, Leach PT, Kazdoba TM, Bleickardt CJ, Lu SX, Parker EM, Varty GB. Characterization of the selective mGluR1 antagonist, JNJ16259685, in rodent models of movement and coordination. Pharmacology, Biochemistry, and Behavior. 98: 181-7. PMID 21122808 DOI: 10.1016/J.Pbb.2010.11.018  1
2004 Fantegrossi WE, Kiessel CL, Leach PT, Van Martin C, Karabenick RL, Chen X, Ohizumi Y, Ullrich T, Rice KC, Woods JH. Nantenine: an antagonist of the behavioral and physiological effects of MDMA in mice. Psychopharmacology. 173: 270-7. PMID 14740148 DOI: 10.1007/S00213-003-1741-2  1
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