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Markus Heilig - Publications

Affiliations: 
National Institute on Alcohol Abuse and Alcoholism, North Bethesda, MD, United States 
Area:
Alcohol, behavioral pharmacology, target discovery and validation
Website:
http://www.niaaa.nih.gov/ResearchInformation/IntramuralResearch/AboutDICBR/LCTS/MP/

178 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Perini I, Kroll S, Mayo LM, Heilig M. Social Acts and Anticipation of Social Feedback. Current Topics in Behavioral Neurosciences. PMID 34784025 DOI: 10.1007/7854_2021_274  0.496
2021 Mayo LM, Rabinak CA, Hill MN, Heilig M. Targeting the Endocannabinoid System in the Treatment of Posttraumatic Stress Disorder: A Promising Case of Preclinical-Clinical Translation? Biological Psychiatry. PMID 34598785 DOI: 10.1016/j.biopsych.2021.07.019  0.537
2021 Kroll SL, Mayo LM, Asratian A, Yngve A, Perini I, Heilig M. Negative self-evaluation induced by acute stress indexed using facial EMG. Psychoneuroendocrinology. 133: 105402. PMID 34530295 DOI: 10.1016/j.psyneuen.2021.105402  0.53
2021 Capusan AJ, Gustafsson PA, Kuja-Halkola R, Igelström K, Mayo LM, Heilig M. Correction: Re-examining the link between childhood maltreatment and substance use disorder: a prospective, genetically informative study. Molecular Psychiatry. PMID 33931734 DOI: 10.1038/s41380-021-01115-z  0.498
2021 Perini I, Gustafsson PA, Igelström K, Jasiunaite-Jokubaviciene B, Kämpe R, Mayo LM, Molander J, Olausson H, Zetterqvist M, Heilig M. Altered relationship between subjective perception and central representation of touch hedonics in adolescents with autism-spectrum disorder. Translational Psychiatry. 11: 224. PMID 33866324 DOI: 10.1038/s41398-021-01341-7  0.509
2021 Capusan AJ, Gustafsson PA, Kuja-Halkola R, Igelström K, Mayo L, Heilig M. Re-examining the link between childhood maltreatment and substance use disorder: a prospective, genetically informative study. Molecular Psychiatry. PMID 33824431 DOI: 10.1038/s41380-021-01071-8  0.497
2020 Mayo LM, Perini I, Gustafsson PA, Hamilton JP, Kämpe R, Heilig M, Zetterqvist M. Psychophysiological and Neural Support for Enhanced Emotional Reactivity in Female Adolescents With Nonsuicidal Self-injury. Biological Psychiatry. Cognitive Neuroscience and Neuroimaging. PMID 33541848 DOI: 10.1016/j.bpsc.2020.11.004  0.493
2020 Schwandt ML, Diazgranados N, Umhau JC, Kwako LE, George DT, Heilig M. PPARγ activation by pioglitazone does not suppress cravings for alcohol, and is associated with a risk of myopathy in treatment seeking alcohol dependent patients: a randomized controlled proof of principle study. Psychopharmacology. PMID 32445052 DOI: 10.1007/S00213-020-05540-W  0.4
2020 Ray LA, Grodin EN, Leggio L, Bechtholt AJ, Becker H, Feldstein Ewing SW, Jentsch JD, King AC, Mason BJ, O'Malley S, MacKillop J, Heilig M, Koob GF. The future of translational research on alcohol use disorder. Addiction Biology. e12903. PMID 32286721 DOI: 10.1111/Adb.12903  0.552
2020 Best LM, Williams B, Le Foll B, Mansouri E, Bazinet RP, Lin L, De Luca V, Lagzdins D, Rusjan P, Tyndale RF, Wilson AA, Hendershot CS, Heilig M, Houle S, Tong J, et al. Lower brain fatty acid amide hydrolase in treatment-seeking patients with alcohol use disorder: a positron emission tomography study with [C-11]CURB. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 31910433 DOI: 10.1038/S41386-020-0606-2  0.379
2020 Blokhin I, Van Booven D, Mayfield D, Argemi J, Bataller R, Barbier E, Heilig M, Wahlestedt C. Genome-Wide Effects of Alcohol Use Disorder on Long Non-Coding RNAs and Splicing in Brain and Liver Biological Psychiatry. 87: S178-S179. DOI: 10.1016/J.Biopsych.2020.02.469  0.314
2019 Muench C, Charlet K, Balderston NL, Grillon C, Heilig M, Cortes CR, Momenan R, Lohoff FW. Fear conditioning and extinction in alcohol dependence: Evidence for abnormal amygdala reactivity. Addiction Biology. e12835. PMID 31702089 DOI: 10.1111/Adb.12835  0.323
2019 Domi E, Caputi FF, Romualdi P, Domi A, Scuppa G, Candeletti S, Atkins A, Heilig M, Demopulos G, Gaitanaris G, Ciccocioppo R, Ubaldi M. Activation of PPARγ attenuates the expression of physical and affective nicotine withdrawal symptoms through mechanisms involving amygdala and hippocampus neurotransmission. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31685649 DOI: 10.1523/Jneurosci.1922-19.2019  0.492
2019 Mayo LM, Asratian A, Lindé J, Morena M, Haataja R, Hammar V, Augier G, Hill MN, Heilig M. Elevated Anandamide, Enhanced Recall of Fear Extinction, and Attenuated Stress Responses Following Inhibition of Fatty Acid Amide Hydrolase: A Randomized, Controlled Experimental Medicine Trial. Biological Psychiatry. PMID 31590924 DOI: 10.1016/J.Biopsych.2019.07.034  0.569
2019 Perini I, Gustafsson PA, Hamilton JP, Kämpe R, Mayo LM, Heilig M, Zetterqvist M. Brain-based Classification of Negative Social Bias in Adolescents With Nonsuicidal Self-injury: Findings From Simulated Online Social Interaction. Eclinicalmedicine. 13: 81-90. PMID 31517265 DOI: 10.1016/J.Eclinm.2019.06.016  0.554
2019 Carvalho AF, Heilig M, Perez A, Probst C, Rehm J. Alcohol use disorders. Lancet (London, England). 394: 781-792. PMID 31478502 DOI: 10.1016/S0140-6736(19)31775-1  0.374
2019 Rehm J, Heilig M, Gual A. ICD-11 for Alcohol Use Disorders: Not a Convincing Answer to the Challenges. Alcoholism, Clinical and Experimental Research. PMID 31424579 DOI: 10.1111/Acer.14182  0.367
2019 Johnstone AL, Andrade NS, Barbier E, Khomtchouk BB, Rienas CA, Lowe K, Van Booven DJ, Domi E, Esanov R, Vilca S, Tapocik JD, Rodriguez K, Maryanski D, Keogh MC, Meinhardt MW, ... ... Heilig M, et al. Dysregulation of the histone demethylase KDM6B in alcohol dependence is associated with epigenetic regulation of inflammatory signaling pathways. Addiction Biology. e12816. PMID 31373129 DOI: 10.1111/Adb.12816  0.387
2019 Nelson BS, Fulenwider HD, Nennig SE, Smith BM, Sequeira MK, Chimberoff SH, Richie CT, Cheng K, Rice KC, Harvey BK, Heilig M, Schank JR. Escalated Alcohol Self-Administration and Sensitivity to Yohimbine-Induced Reinstatement in Alcohol Preferring Rats: Potential Role of Neurokinin-1 Receptors in the Amygdala. Neuroscience. PMID 31242442 DOI: 10.1016/J.Neuroscience.2019.06.023  0.414
2019 Mayo LM, Heilig M. In the face of stress: Interpreting individual differences in stress-induced facial expressions. Neurobiology of Stress. 10: 100166. PMID 31193535 DOI: 10.1016/J.Ynstr.2019.100166  0.564
2019 Ree A, Morrison I, Olausson H, Sailer U, Heilig M, Mayo LM. Using Facial Electromyography to Assess Facial Muscle Reactions to Experienced and Observed Affective Touch in Humans. Journal of Visualized Experiments : Jove. PMID 30933066 DOI: 10.3791/59228  0.553
2019 Mayo L, Linde J, Asratian A, Morena M, Hill M, Heilig M. S31. Beneficial Effects of FAAH Inhibition on Fear- and Stress-Related Behaviors in Healthy Humans Biological Psychiatry. 85: S308. DOI: 10.1016/J.Biopsych.2019.03.782  0.567
2019 Perini I, Gustafsson P, Hamilton P, Kämpe R, Mayo L, Zetterqvist M, Heilig M. T57. Social Interaction Processing in Adolescents With Non-Suicidal Self-Injury (NSSI) Behavior Biological Psychiatry. 85: S150-S151. DOI: 10.1016/J.Biopsych.2019.03.380  0.538
2018 Mayo LM, Heilig M. A Hippocampal Signature of Posttraumatic Stress Disorder Vulnerability. Biological Psychiatry. 84: 78-79. PMID 31178061 DOI: 10.1016/J.Biopsych.2018.04.015  0.556
2018 Grodin EN, Sussman L, Sundby K, Brennan GM, Diazgranados N, Heilig M, Momenan R. Neural Correlates of Compulsive Alcohol Seeking in Heavy Drinkers. Biological Psychiatry. Cognitive Neuroscience and Neuroimaging. PMID 30143454 DOI: 10.1016/J.Bpsc.2018.06.009  0.404
2018 Mayo LM, Asratian A, Lindé J, Holm L, Nätt D, Augier G, Stensson N, Vecchiarelli HA, Balsevich G, Aukema RJ, Ghafouri B, Spagnolo PA, Lee FS, Hill MN, Heilig M. Protective effects of elevated anandamide on stress and fear-related behaviors: translational evidence from humans and mice. Molecular Psychiatry. PMID 30120421 DOI: 10.1038/S41380-018-0215-1  0.586
2018 Mayo LM, Lindé J, Olausson H, Heilig M, Morrison I. Putting a good face on touch: Facial expression reflects the affective valence of caress-like touch across modalities. Biological Psychology. PMID 30003943 DOI: 10.1016/J.Biopsycho.2018.07.001  0.551
2018 Augier E, Barbier E, Dulman RS, Licheri V, Augier G, Domi E, Barchiesi R, Farris S, Nätt D, Mayfield RD, Adermark L, Heilig M. A molecular mechanism for choosing alcohol over an alternative reward. Science (New York, N.Y.). 360: 1321-1326. PMID 29930131 DOI: 10.1126/Science.Aao1157  0.413
2018 Sequeira MK, Nelson BS, Fulenwider HD, King CE, Nennig SE, Bohannon JB, Cheng K, Rice KC, Heilig M, Schank JR. The neurokinin-1 receptor mediates escalated alcohol intake induced by multiple drinking models. Neuropharmacology. 137: 194-201. PMID 29758386 DOI: 10.1016/J.Neuropharm.2018.05.005  0.427
2018 Lee MR, Tapocik JD, Ghareeb M, Schwandt ML, Dias AA, Le AN, Cobbina E, Farinelli LA, Bouhlal S, Farokhnia M, Heilig M, Akhlaghi F, Leggio L. The novel ghrelin receptor inverse agonist PF-5190457 administered with alcohol: preclinical safety experiments and a phase 1b human laboratory study. Molecular Psychiatry. PMID 29728704 DOI: 10.1038/S41380-018-0064-Y  0.41
2018 Lee JS, Sorcher JL, Rosen AD, Damadzic R, Sun H, Schwandt M, Heilig M, Kelly J, Mauro KL, Luo A, Rosoff D, Muench C, Jung J, Kaminsky ZA, Lohoff FW. Genetic Association and Expression Analyses of the Phosphatidylinositol-4-Phosphate 5-Kinase (PIP5K1C) Gene in Alcohol Use Disorder - Relevance for Pain Signaling and Alcohol Use. Alcoholism, Clinical and Experimental Research. PMID 29667742 DOI: 10.1111/Acer.13751  0.335
2018 Van Hedger K, Keedy SK, Mayo LM, Heilig M, de Wit H. Neural responses to cues paired with methamphetamine in healthy volunteers. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 29463908 DOI: 10.1038/S41386-017-0005-5  0.637
2018 Zallar LJ, Tunstall BJ, Richie CT, Zhang YJ, You ZB, Gardner EL, Heilig M, Pickel J, Koob GF, Vendruscolo LF, Harvey BK, Leggio L. Development and initial characterization of a novel ghrelin receptor CRISPR/Cas9 knockout wistar rat model. International Journal of Obesity (2005). PMID 29453460 DOI: 10.1038/S41366-018-0013-5  0.564
2018 Cortes CR, Grodin EN, Mann CL, Mathur K, Kerich M, Zhu X, Schwandt M, Diazgranados N, George DT, Momenan R, Heilig M. Insula Sensitivity to Unfairness in Alcohol Use Disorder. Alcohol and Alcoholism (Oxford, Oxfordshire). PMID 29309499 DOI: 10.1093/Alcalc/Agx115  0.36
2018 Heilig M, Wahlestedt C, Barbier E, Johnstone A. 10. Epigenetic Enzymes as Novel Therapeutic Targets in Alcohol Addiction Biological Psychiatry. 83: S4. DOI: 10.1016/J.Biopsych.2018.02.027  0.351
2017 Malik S, Jacobs M, Cho SS, Boileau I, Blumberger D, Heilig M, Wilson A, Daskalakis ZJ, Strafella AP, Zangen A, Le Foll B. Deep TMS of the insula using the H-coil modulates dopamine release: a crossover [(11)C] PHNO-PET pilot trial in healthy humans. Brain Imaging and Behavior. PMID 29170944 DOI: 10.1007/S11682-017-9800-1  0.31
2017 Baker M, Lindell SG, Driscoll CA, Zhou Z, Yuan Q, Schwandt ML, Miller-Crews I, Simpson EA, Paukner A, Ferrari PF, Sindhu RK, Razaqyar M, Sommer WH, Lopez JF, Thompson RC, ... ... Heilig M, et al. Early rearing history influences oxytocin receptor epigenetic regulation in rhesus macaques. Proceedings of the National Academy of Sciences of the United States of America. PMID 29078292 DOI: 10.1073/Pnas.1706206114  0.321
2017 Schank JR, Heilig M. Substance P and the Neurokinin-1 Receptor: The New CRF. International Review of Neurobiology. 136: 151-175. PMID 29056150 DOI: 10.1016/Bs.Irn.2017.06.008  0.364
2017 Nennig SE, Fulenwider HD, Chimberoff SH, Smith BM, Eskew JE, Sequeira MK, Karlsson C, Liang C, Chen J, Heilig M, Schank JR. Selective Lesioning of Nuclear Factor kB Activated Cells in the Nucleus Accumbens Shell Attenuates Alcohol Place Preference. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 28901327 DOI: 10.1038/Npp.2017.214  0.397
2017 Aoun EG, Jimenez VA, Vendruscolo LF, Walter NAR, Barbier E, Ferrulli A, Haass-Koffler CL, Darakjian P, Lee MR, Addolorato G, Heilig M, Hitzemann R, Koob GF, Grant KA, Leggio L. A relationship between the aldosterone-mineralocorticoid receptor pathway and alcohol drinking: preliminary translational findings across rats, monkeys and humans. Molecular Psychiatry. PMID 28461696 DOI: 10.1038/Mp.2017.97  0.615
2017 Badiani A, Berridge KC, Heilig M, Nutt DJ, Robinson TE. Addiction research and theory: a commentary on the Surgeon General's Report on alcohol, drugs, and health. Addiction Biology. PMID 28224686 DOI: 10.1111/Adb.12497  0.333
2017 Persson A, Back SE, Killeen TK, Brady KT, Schwandt ML, Heilig M, Magnusson Å. Concurrent Treatment of PTSD and Substance Use Disorders Using Prolonged Exposure (COPE): A Pilot Study in Alcohol-dependent Women. Journal of Addiction Medicine. PMID 28079572 DOI: 10.1097/Adm.0000000000000286  0.309
2017 Grodin E, Sussman L, Sundby K, Brennan G, Heilig M, Momenan R. 196. The Neural Correlates of Compulsive Alcohol Seeking Biological Psychiatry. 81. DOI: 10.1016/J.Biopsych.2017.02.209  0.372
2017 Barbier E, Johnstone A, Khomtchouk B, Tapocik J, Pitcairn C, Rehman F, Augier E, Borich A, Schank J, Rienas C, Van Booven D, Sun H, Nätt D, Wahlestedt C, Heilig M. Epigenetic enzymes as a novel class of targets for disease-modifying pharmacotherapies in alcohol addiction Alcohol. 60: 209. DOI: 10.1016/J.Alcohol.2017.02.211  0.337
2016 Domi E, Uhrig S, Soverchia L, Spanagel R, Hansson AC, Barbier E, Heilig M, Ciccocioppo R, Ubaldi M. Genetic deletion of neuronal PPARγ enhances the emotional response to acute stress and exacerbates anxiety: An effect reversed by rescue of amygdala PPARγ function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 27810934 DOI: 10.1523/Jneurosci.4127-15.2016  0.492
2016 Spagnolo PA, Ramchandani VA, Schwandt ML, Kwako LE, George DT, Mayo LM, Hillard CJ, Heilig M. FAAH Gene Variation Moderates Stress Response and Symptom Severity in Patients with Posttraumatic Stress Disorder and Comorbid Alcohol Dependence. Alcoholism, Clinical and Experimental Research. PMID 27716956 DOI: 10.1111/Acer.13210  0.604
2016 Heilig M, Barbier E, Johnstone AL, Tapocik J, Meinhardt MW, Pfarr S, Wahlestedt CR, Sommer WH. Reprogramming of mPFC transcriptome and function in alcohol dependence. Genes, Brain, and Behavior. PMID 27657733 DOI: 10.1111/Gbb.12344  0.398
2016 Karlsson C, Rehman F, Damadzic R, Atkins AL, Schank JR, Gehlert DR, Steensland P, Thorsell A, Heilig M. Erratum to: The melanin-concentrating hormone-1 receptor modulates alcohol-induced reward and DARPP-32 phosphorylation. Psychopharmacology. PMID 27650828 DOI: 10.1007/S00213-016-4434-3  0.398
2016 Epstein DH, Kennedy AP, Furnari M, Heilig M, Shaham Y, Phillips KA, Preston KL. Effect of the CRF1-receptor antagonist pexacerfont on stress-induced eating and food craving. Psychopharmacology. PMID 27595147 DOI: 10.1007/S00213-016-4424-5  0.323
2016 Barbier E, Johnstone AL, Khomtchouk BB, Tapocik JD, Pitcairn C, Rehman F, Augier E, Borich A, Schank JR, Rienas CA, Van Booven DJ, Sun H, Nätt D, Wahlestedt C, Heilig M. Dependence-induced increase of alcohol self-administration and compulsive drinking mediated by the histone methyltransferase PRDM2. Molecular Psychiatry. PMID 27573876 DOI: 10.1038/Mp.2016.131  0.412
2016 Aziz AM, Brothers S, Sartor G, Holm L, Heilig M, Wahlestedt C, Thorsell A. The nociceptin/orphanin FQ receptor agonist SR-8993 as a candidate therapeutic for alcohol use disorders: validation in rat models. Psychopharmacology. PMID 27515665 DOI: 10.1016/J.Alcohol.2017.02.313  0.432
2016 Driscoll CA, Lindell SG, Schwandt ML, Suomi SJ, Higley JD, Heilig M, Barr CS. OPRM1 genotype interacts with serotonin system dysfunction to predict alcohol-heightened aggression in primates. Addiction Biology. PMID 27484010 DOI: 10.1111/Adb.12428  0.393
2016 Augier E, Dulman RS, Rauffenbart C, Augier G, Cross AJ, Heilig M. The mGluR2 Positive Allosteric Modulator, AZD8529 and Cue-Induced Relapse to Alcohol Seeking in Rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27339394 DOI: 10.1038/Npp.2016.107  0.746
2016 Karlsson C, Schank JR, Rehman F, Stojakovic A, Björk K, Barbier E, Solomon M, Tapocik J, Engblom D, Thorsell A, Heilig M. Proinflammatory signaling regulates voluntary alcohol intake and stress-induced consumption after exposure to social defeat stress in mice. Addiction Biology. PMID 27273552 DOI: 10.1111/Adb.12416  0.387
2016 Sells JR, Waters AJ, Schwandt ML, Kwako LE, Heilig M, George DT, Ramchandani VA. Characterization of comorbid PTSD in treatment-seeking alcohol dependent inpatients: Severity and personality trait differences. Drug and Alcohol Dependence. PMID 27114205 DOI: 10.1016/J.Drugalcdep.2016.03.016  0.361
2016 Schwandt ML, Cortes CR, Kwako LE, George DT, Momenan R, Sinha R, Grigoriadis DE, Leggio L, Heilig M. The CRF1 Antagonist Verucerfont in Anxious Alcohol Dependent Women: Translation of Neuroendocrine, but not of Anti-Craving Effects. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27109623 DOI: 10.1038/Npp.2016.61  0.434
2016 Gowin JL, Vatsalya V, Westman JG, Schwandt ML, Bartlett S, Heilig M, Momenan R, Ramchandani VA. The Effect of Varenicline on the Neural Processing of Fearful Faces and the Subjective Effects of Alcohol in Heavy Drinkers. Alcoholism, Clinical and Experimental Research. PMID 27062270 DOI: 10.1111/Acer.13046  0.384
2016 Caruso V, Sreedharan S, Carlini VP, Jacobsson JA, Haitina T, Hammer J, Stephansson O, Crona F, Sommer WH, Risérus U, Lannfelt L, Marcus C, Heilig M, de Barioglio SR, Fredriksson R, et al. mRNA GPR162 changes are associated with decreased food intake in rat, and its human genetic variants with impairments in glucose homeostasis in two Swedish cohorts. Gene. PMID 26827797 DOI: 10.1016/J.Gene.2016.01.044  0.302
2016 Heilig M, Leggio L. What the alcohol doctor ordered from the neuroscientist: Theragnostic biomarkers for personalized treatments. Progress in Brain Research. 224: 401-18. PMID 26822368 DOI: 10.1016/Bs.Pbr.2015.07.023  0.378
2015 Herman MA, Varodayan FP, Oleata CS, Luu G, Kirson D, Heilig M, Ciccocioppo R, Roberto M. Glutamatergic transmission in the central nucleus of the amygdala is selectively altered in Marchigian Sardinian alcohol-preferring rats: Alcohol and CRF effects. Neuropharmacology. 102: 21-31. PMID 26519902 DOI: 10.1016/J.Neuropharm.2015.10.027  0.544
2015 Ayanwuyi LO, Stopponi S, Ubaldi M, Cippitelli A, Nasuti C, Damadzic R, Heilig M, Schank J, Cheng K, Rice KC, Ciccocioppo R. Neurokinin 1 receptor blockade in the medial amygdala attenuates alcohol drinking in rats with innate anxiety but not in wistar rats. British Journal of Pharmacology. PMID 26275374 DOI: 10.1111/Bph.13280  0.577
2015 Vatsalya V, Gowin JL, Schwandt ML, Momenan R, Coe MA, Cooke ME, Hommer DW, Bartlett S, Heilig M, Ramchandani VA. Effects of Varenicline on Neural Correlates of Alcohol Salience in Heavy Drinkers. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). PMID 26209857 DOI: 10.1093/Ijnp/Pyv068  0.392
2015 Suchankova P, Yan J, Schwandt ML, Stangl BL, Caparelli EC, Momenan R, Jerlhag E, Engel JA, Hodgkinson CA, Egli M, Lopez MF, Becker HC, Goldman D, Heilig M, Ramchandani VA, et al. The glucagon-like peptide-1 receptor as a potential treatment target in alcohol use disorder: evidence from human genetic association studies and a mouse model of alcohol dependence. Translational Psychiatry. 5: e583. PMID 26080318 DOI: 10.1038/Tp.2015.68  0.414
2015 Robinson JE, Vardy E, DiBerto JF, Chefer VI, White KL, Fish EW, Chen M, Gigante E, Krouse MC, Sun H, Thorsell A, Roth BL, Heilig M, Malanga CJ. Receptor Reserve Moderates Mesolimbic Responses to Opioids in a Humanized Mouse Model of the OPRM1 A118G Polymorphism. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 2614-22. PMID 25881115 DOI: 10.1038/Npp.2015.109  0.687
2015 Barbier E, Tapocik JD, Juergens N, Pitcairn C, Borich A, Schank JR, Sun H, Schuebel K, Zhou Z, Yuan Q, Vendruscolo LF, Goldman D, Heilig M. DNA methylation in the medial prefrontal cortex regulates alcohol-induced behavior and plasticity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 6153-64. PMID 25878287 DOI: 10.1523/Jneurosci.4571-14.2015  0.385
2015 Spagnolo PA, Colloca L, Heilig M. The role of expectation in the therapeutic outcomes of alcohol and drug addiction treatments. Alcohol and Alcoholism (Oxford, Oxfordshire). 50: 282-5. PMID 25761920 DOI: 10.1093/Alcalc/Agv015  0.35
2015 de Guglielmo G, Melis M, De Luca MA, Kallupi M, Li HW, Niswender K, Giordano A, Senzacqua M, Somaini L, Cippitelli A, Gaitanaris G, Demopulos G, Damadzic R, Tapocik J, Heilig M, et al. PPARc activation attenuates opioid consumption and modulates mesolimbic dopamine transmission. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 1052. PMID 25668637 DOI: 10.1038/Npp.2014.305  0.531
2015 Bilbao A, Robinson JE, Heilig M, Malanga CJ, Spanagel R, Sommer WH, Thorsell A. A pharmacogenetic determinant of mu-opioid receptor antagonist effects on alcohol reward and consumption: evidence from humanized mice. Biological Psychiatry. 77: 850-8. PMID 25442002 DOI: 10.1016/J.Biopsych.2014.08.021  0.706
2015 Kwako LE, Spagnolo PA, Schwandt ML, Thorsell A, George DT, Momenan R, Rio DE, Huestis M, Anizan S, Concheiro M, Sinha R, Heilig M. The corticotropin releasing hormone-1 (CRH1) receptor antagonist pexacerfont in alcohol dependence: a randomized controlled experimental medicine study. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 1053-63. PMID 25409596 DOI: 10.1038/Npp.2014.306  0.432
2015 Schmeichel BE, Barbier E, Misra KK, Contet C, Schlosburg JE, Grigoriadis D, Williams JP, Karlsson C, Pitcairn C, Heilig M, Koob GF, Vendruscolo LF. Hypocretin receptor 2 antagonism dose-dependently reduces escalated heroin self-administration in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 1123-9. PMID 25367502 DOI: 10.1038/Npp.2014.293  0.776
2015 Senatorov VV, Damadzic R, Mann CL, Schwandt ML, George DT, Hommer DW, Heilig M, Momenan R. Reduced anterior insula, enlarged amygdala in alcoholism and associated depleted von Economo neurons. Brain : a Journal of Neurology. 138: 69-79. PMID 25367022 DOI: 10.1093/Brain/Awu305  0.389
2015 de Guglielmo G, Melis M, De Luca MA, Kallupi M, Li HW, Niswender K, Giordano A, Senzacqua M, Somaini L, Cippitelli A, Gaitanaris G, Demopulos G, Damadzic R, Tapocik J, Heilig M, et al. PPARγ activation attenuates opioid consumption and modulates mesolimbic dopamine transmission. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 927-37. PMID 25311134 DOI: 10.1038/npp.2014.268  0.473
2015 Cippitelli A, Ayanwuyi LO, Barbier E, Domi E, Lerma-Cabrera JM, Carvajal F, Scuppa G, Li H, Ubaldi M, Heilig M, Roberto M, Ciccocioppo R. Polymorphism in the corticotropin-releasing factor receptor 1 (CRF1-R) gene plays a role in shaping the high anxious phenotype of Marchigian Sardinian alcohol-preferring (msP) rats. Psychopharmacology. 232: 1083-93. PMID 25260340 DOI: 10.1007/S00213-014-3743-7  0.579
2015 Kwako LE, George DT, Schwandt ML, Spagnolo PA, Momenan R, Hommer DW, Diamond CA, Sinha R, Shaham Y, Heilig M. The neurokinin-1 receptor antagonist aprepitant in co-morbid alcohol dependence and posttraumatic stress disorder: a human experimental study. Psychopharmacology. 232: 295-304. PMID 25030801 DOI: 10.1007/S00213-014-3665-4  0.407
2015 Kwako LE, Schwandt ML, Sells JR, Ramchandani VA, Hommer DW, George DT, Sinha R, Heilig M. Methods for inducing alcohol craving in individuals with co-morbid alcohol dependence and posttraumatic stress disorder: behavioral and physiological outcomes. Addiction Biology. 20: 733-46. PMID 24806358 DOI: 10.1111/Adb.12150  0.408
2015 Suchankova P, Yan, J, Schwandt ML, Stangl BL, Caparelli EC, Momenan R, Hodgkinson CA, Goldman D, Heilig M, Ramchandani VA, Nilsson S, von der Pahlen B, Santtila P, Sandnabba K, et al. SY15-3THE ROLE OF THE GUT-BRAIN-AXIS IN SUBSTANCE USE DISORDERS: EVIDENCE FROM HUMAN GENETIC STUDIES Alcohol and Alcoholism. 50: i18.1-i18. DOI: 10.1093/Alcalc/Agv076.63  0.358
2014 Spagnolo PA, Ramchandani VA, Schwandt ML, Zhang L, Blaine SK, Usala JM, Diamond KA, Phillips MJ, George DT, Momenan R, Heilig M. Effects of naltrexone on neural and subjective response to alcohol in treatment-seeking alcohol-dependent patients. Alcoholism, Clinical and Experimental Research. 38: 3024-32. PMID 25581657 DOI: 10.1111/Acer.12581  0.779
2014 Ciccocioppo R, Stopponi S, Economidou D, Kuriyama M, Kinoshita H, Heilig M, Roberto M, Weiss F, Teshima K. Chronic treatment with novel brain-penetrating selective NOP receptor agonist MT-7716 reduces alcohol drinking and seeking in the rat. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 2601-10. PMID 24863033 DOI: 10.1038/Npp.2014.113  0.726
2014 Heilig M, Schank JR. Kappa-opioid receptor antagonism: a mechanism for treatment of relief drinking? Biological Psychiatry. 75: 750-1. PMID 24780009 DOI: 10.1016/J.Biopsych.2014.03.004  0.424
2014 Umhau JC, Schwandt M, Solomon MG, Yuan P, Nugent A, Zarate CA, Drevets WC, Hall SD, George DT, Heilig M. Cerebrospinal fluid monocyte chemoattractant protein-1 in alcoholics: support for a neuroinflammatory model of chronic alcoholism. Alcoholism, Clinical and Experimental Research. 38: 1301-6. PMID 24689518 DOI: 10.1111/Acer.12367  0.371
2014 Tapocik JD, Barbier E, Flanigan M, Solomon M, Pincus A, Pilling A, Sun H, Schank JR, King C, Heilig M. microRNA-206 in rat medial prefrontal cortex regulates BDNF expression and alcohol drinking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 4581-8. PMID 24672003 DOI: 10.1523/Jneurosci.0445-14.2014  0.321
2014 Yong W, Spence JP, Eskay R, Fitz SD, Damadzic R, Lai D, Foroud T, Carr LG, Shekhar A, Chester JA, Heilig M, Liang T. Alcohol-preferring rats show decreased corticotropin-releasing hormone-2 receptor expression and differences in HPA activation compared to alcohol-nonpreferring rats. Alcoholism, Clinical and Experimental Research. 38: 1275-83. PMID 24611993 DOI: 10.1111/Acer.12379  0.406
2014 Huang MC, Schwandt ML, Chester JA, Kirchhoff AM, Kao CF, Liang T, Tapocik JD, Ramchandani VA, George DT, Hodgkinson CA, Goldman D, Heilig M. FKBP5 moderates alcohol withdrawal severity: human genetic association and functional validation in knockout mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 2029-38. PMID 24603855 DOI: 10.1038/Npp.2014.55  0.371
2014 Ciccocioppo R, de Guglielmo G, Hansson AC, Ubaldi M, Kallupi M, Cruz MT, Oleata CS, Heilig M, Roberto M. Restraint stress alters nociceptin/orphanin FQ and CRF systems in the rat central amygdala: significance for anxiety-like behaviors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 363-72. PMID 24403138 DOI: 10.1523/Jneurosci.2400-13.2014  0.534
2014 Lee MR, Cacic K, Demers CH, Haroon M, Heishman S, Hommer DW, Epstein DH, Ross TJ, Stein EA, Heilig M, Salmeron BJ. Gender differences in neural-behavioral response to self-observation during a novel fMRI social stress task. Neuropsychologia. 53: 257-63. PMID 24316200 DOI: 10.1016/J.Neuropsychologia.2013.11.022  0.307
2014 Schank JR, King CE, Sun H, Cheng K, Rice KC, Heilig M, Weinshenker D, Schroeder JP. The role of the neurokinin-1 receptor in stress-induced reinstatement of alcohol and cocaine seeking. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 1093-101. PMID 24173499 DOI: 10.1038/Npp.2013.309  0.406
2013 Zhou Z, Karlsson C, Liang T, Xiong W, Kimura M, Tapocik JD, Yuan Q, Barbier E, Feng A, Flanigan M, Augier E, Enoch MA, Hodgkinson CA, Shen PH, Lovinger DM, ... ... Heilig M, et al. Loss of metabotropic glutamate receptor 2 escalates alcohol consumption. Proceedings of the National Academy of Sciences of the United States of America. 110: 16963-8. PMID 24082084 DOI: 10.1073/Pnas.1309839110  0.408
2013 Thorsell A, Tapocik JD, Liu K, Zook M, Bell L, Flanigan M, Patnaik S, Marugan J, Damadzic R, Dehdashti SJ, Schwandt ML, Southall N, Austin CP, Eskay R, Ciccocioppo R, ... ... Heilig M, et al. A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 10132-42. PMID 23761908 DOI: 10.1523/Jneurosci.4742-12.2013  0.605
2013 Ayanwuyi LO, Carvajal F, Lerma-Cabrera JM, Domi E, Björk K, Ubaldi M, Heilig M, Roberto M, Ciccocioppo R, Cippitelli A. Role of a genetic polymorphism in the corticotropin-releasing factor receptor 1 gene in alcohol drinking and seeking behaviors of marchigian sardinian alcohol-preferring rats. Frontiers in Psychiatry. 4: 23. PMID 23630503 DOI: 10.3389/Fpsyt.2013.00023  0.604
2013 Stopponi S, de Guglielmo G, Somaini L, Cippitelli A, Cannella N, Kallupi M, Ubaldi M, Heilig M, Demopulos G, Gaitanaris G, Ciccocioppo R. Activation of PPARγ by pioglitazone potentiates the effects of naltrexone on alcohol drinking and relapse in msP rats. Alcoholism, Clinical and Experimental Research. 37: 1351-60. PMID 23550625 DOI: 10.1111/Acer.12091  0.603
2013 Schank JR, Tapocik JD, Barbier E, Damadzic R, Eskay RL, Sun H, Rowe KE, King CE, Yao M, Flanigan ME, Solomon MG, Karlsson C, Cheng K, Rice KC, Heilig M. Tacr1 gene variation and neurokinin 1 receptor expression is associated with antagonist efficacy in genetically selected alcohol-preferring rats. Biological Psychiatry. 73: 774-81. PMID 23419547 DOI: 10.1016/J.Biopsych.2012.12.027  0.42
2013 Mayo LM, Fraser D, Childs E, Momenan R, Hommer DW, de Wit H, Heilig M. Conditioned preference to a methamphetamine-associated contextual cue in humans. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 921-9. PMID 23416857 DOI: 10.1038/Npp.2013.3  0.637
2013 Barbier E, Vendruscolo LF, Schlosburg JE, Edwards S, Juergens N, Park PE, Misra KK, Cheng K, Rice KC, Schank J, Schulteis G, Koob GF, Heilig M. The NK1 receptor antagonist L822429 reduces heroin reinforcement. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 976-84. PMID 23303056 DOI: 10.1038/Npp.2012.261  0.781
2013 Zorrilla EP, Heilig M, de Wit H, Shaham Y. Behavioral, biological, and chemical perspectives on targeting CRF(1) receptor antagonists to treat alcoholism. Drug and Alcohol Dependence. 128: 175-86. PMID 23294766 DOI: 10.1016/J.Drugalcdep.2012.12.017  0.713
2013 Schwandt ML, Heilig M, Hommer DW, George DT, Ramchandani VA. Childhood trauma exposure and alcohol dependence severity in adulthood: mediation by emotional abuse severity and neuroticism. Alcoholism, Clinical and Experimental Research. 37: 984-92. PMID 23278300 DOI: 10.1111/Acer.12053  0.362
2013 Herman MA, Kallupi M, Luu G, Oleata CS, Heilig M, Koob GF, Ciccocioppo R, Roberto M. Enhanced GABAergic transmission in the central nucleus of the amygdala of genetically selected Marchigian Sardinian rats: alcohol and CRF effects. Neuropharmacology. 67: 337-48. PMID 23220399 DOI: 10.1016/J.Neuropharm.2012.11.026  0.677
2013 Hirvonen J, Zanotti-Fregonara P, Umhau JC, George DT, Rallis-Frutos D, Lyoo CH, Li CT, Hines CS, Sun H, Terry GE, Morse C, Zoghbi SS, Pike VW, Innis RB, Heilig M. Reduced cannabinoid CB1 receptor binding in alcohol dependence measured with positron emission tomography. Molecular Psychiatry. 18: 916-21. PMID 22776901 DOI: 10.1038/Mp.2012.100  0.408
2013 Tapocik JD, Solomon M, Flanigan M, Meinhardt M, Barbier E, Schank JR, Schwandt M, Sommer WH, Heilig M. Coordinated dysregulation of mRNAs and microRNAs in the rat medial prefrontal cortex following a history of alcohol dependence. The Pharmacogenomics Journal. 13: 286-96. PMID 22614244 DOI: 10.1038/Tpj.2012.17  0.355
2013 Walsh SL, Heilig M, Nuzzo PA, Henderson P, Lofwall MR. Effects of the NK1 antagonist, aprepitant, on response to oral and intranasal oxycodone in prescription opioid abusers. Addiction Biology. 18: 332-43. PMID 22260216 DOI: 10.1111/J.1369-1600.2011.00419.X  0.302
2013 Mayo LM, Momenan R, Heilig M, Harriet dW. C.21 - CHARACTERIZATION OF RESPONSES TO A CONDITIONED DRUG CUE IN HEALTHY, NON-DEPENDENT HUMANS Behavioural Pharmacology. 24: e36. DOI: 10.1097/01.Fbp.0000434805.81334.B3  0.559
2012 Schank JR, Ryabinin AE, Giardino WJ, Ciccocioppo R, Heilig M. Stress-related neuropeptides and addictive behaviors: beyond the usual suspects. Neuron. 76: 192-208. PMID 23040815 DOI: 10.1016/J.Neuron.2012.09.026  0.539
2012 Karlsson C, Zook M, Ciccocioppo R, Gehlert DR, Thorsell A, Heilig M, Cippitelli A. Melanin-concentrating hormone receptor 1 (MCH1-R) antagonism: reduced appetite for calories and suppression of addictive-like behaviors. Pharmacology, Biochemistry, and Behavior. 102: 400-6. PMID 22705492 DOI: 10.1016/J.Pbb.2012.06.010  0.541
2012 Vendruscolo LF, Barbier E, Schlosburg JE, Misra KK, Whitfield TW, Logrip ML, Rivier C, Repunte-Canonigo V, Zorrilla EP, Sanna PP, Heilig M, Koob GF. Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 7563-71. PMID 22649234 DOI: 10.1523/Jneurosci.0069-12.2012  0.805
2012 Schank JR, Goldstein AL, Rowe KE, King CE, Marusich JA, Wiley JL, Carroll FI, Thorsell A, Heilig M. The kappa opioid receptor antagonist JDTic attenuates alcohol seeking and withdrawal anxiety. Addiction Biology. 17: 634-47. PMID 22515275 DOI: 10.1111/J.1369-1600.2012.00455.X  0.442
2012 Litten RZ, Egli M, Heilig M, Cui C, Fertig JB, Ryan ML, Falk DE, Moss H, Huebner R, Noronha A. Medications development to treat alcohol dependence: a vision for the next decade. Addiction Biology. 17: 513-27. PMID 22458728 DOI: 10.1111/J.1369-1600.2012.00454.X  0.343
2012 Karlsson RM, Adermark L, Molander A, Perreau-Lenz S, Singley E, Solomon M, Holmes A, Tanaka K, Lovinger DM, Spanagel R, Heilig M. Reduced alcohol intake and reward associated with impaired endocannabinoid signaling in mice with a deletion of the glutamate transporter GLAST. Neuropharmacology. 63: 181-9. PMID 22342743 DOI: 10.1016/J.Neuropharm.2012.01.027  0.401
2012 Molander A, Vengeliene V, Heilig M, Wurst W, Deussing JM, Spanagel R. Brain-specific inactivation of the Crhr1 gene inhibits post-dependent and stress-induced alcohol intake, but does not affect relapse-like drinking. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 1047-56. PMID 22113086 DOI: 10.1038/Npp.2011.297  0.428
2012 Cippitelli A, Damadzic R, Singley E, Thorsell A, Ciccocioppo R, Eskay RL, Heilig M. Pharmacological blockade of corticotropin-releasing hormone receptor 1 (CRH1R) reduces voluntary consumption of high alcohol concentrations in non-dependent Wistar rats. Pharmacology, Biochemistry, and Behavior. 100: 522-9. PMID 22036774 DOI: 10.1016/J.Pbb.2011.10.016  0.492
2012 Chen CH, Walker J, Momenan R, Rawlings R, Heilig M, Hommer DW. Relationship between liver function and brain shrinkage in patients with alcohol dependence. Alcoholism, Clinical and Experimental Research. 36: 625-32. PMID 21995416 DOI: 10.1111/J.1530-0277.2011.01662.X  0.355
2012 Robinson JE, Fish EW, Krouse MC, Thorsell A, Heilig M, Malanga CJ. Potentiation of brain stimulation reward by morphine: effects of neurokinin-1 receptor antagonism. Psychopharmacology. 220: 215-24. PMID 21909635 DOI: 10.1007/S00213-011-2469-Z  0.637
2012 Snell LD, Ramchandani VA, Saba L, Herion D, Heilig M, George DT, Pridzun L, Helander A, Schwandt ML, Phillips MJ, Hoffman PL, Tabakoff B. The biometric measurement of alcohol consumption. Alcoholism, Clinical and Experimental Research. 36: 332-41. PMID 21895709 DOI: 10.1111/J.1530-0277.2011.01605.X  0.356
2012 Magnusson Ã…, Lundholm C, Göransson M, Copeland W, Heilig M, Pedersen NL. Familial influence and childhood trauma in female alcoholism. Psychological Medicine. 42: 381-9. PMID 21798111 DOI: 10.1017/S0033291711001310  0.347
2011 Heilig M, Goldman D, Berrettini W, O'Brien CP. Pharmacogenetic approaches to the treatment of alcohol addiction. Nature Reviews. Neuroscience. 12: 670-84. PMID 22011682 DOI: 10.1038/Nrn3110  0.357
2011 Sinha R, Shaham Y, Heilig M. Translational and reverse translational research on the role of stress in drug craving and relapse. Psychopharmacology. 218: 69-82. PMID 21494792 DOI: 10.1007/S00213-011-2263-Y  0.336
2011 Schwandt ML, Lindell SG, Higley JD, Suomi SJ, Heilig M, Barr CS. OPRM1 gene variation influences hypothalamic-pituitary-adrenal axis function in response to a variety of stressors in rhesus macaques. Psychoneuroendocrinology. 36: 1303-11. PMID 21459516 DOI: 10.1016/J.Psyneuen.2011.03.002  0.337
2011 Rinker JA, Hutchison MA, Chen SA, Thorsell A, Heilig M, Riley AL. Exposure to nicotine during periadolescence or early adulthood alters aversive and physiological effects induced by ethanol. Pharmacology, Biochemistry, and Behavior. 99: 7-16. PMID 21420998 DOI: 10.1016/J.Pbb.2011.03.009  0.558
2011 Schank JR, Pickens CL, Rowe KE, Cheng K, Thorsell A, Rice KC, Shaham Y, Heilig M. Stress-induced reinstatement of alcohol-seeking in rats is selectively suppressed by the neurokinin 1 (NK1) antagonist L822429. Psychopharmacology. 218: 111-9. PMID 21340476 DOI: 10.1007/S00213-011-2201-Z  0.433
2011 Umhau JC, Schwandt ML, Usala J, Geyer C, Singley E, George DT, Heilig M. Pharmacologically induced alcohol craving in treatment seeking alcoholics correlates with alcoholism severity, but is insensitive to acamprosate. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 1178-86. PMID 21289601 DOI: 10.1038/Npp.2010.253  0.41
2011 Stopponi S, Somaini L, Cippitelli A, Cannella N, Braconi S, Kallupi M, Ruggeri B, Heilig M, Demopulos G, Gaitanaris G, Massi M, Ciccocioppo R. Activation of nuclear PPARγ receptors by the antidiabetic agent pioglitazone suppresses alcohol drinking and relapse to alcohol seeking. Biological Psychiatry. 69: 642-9. PMID 21276964 DOI: 10.1016/J.Biopsych.2010.12.010  0.492
2011 Cippitelli A, Rezvani AH, Robinson JE, Eisenberg L, Levin ED, Bonaventure P, Motley ST, Lovenberg TW, Heilig M, Thorsell A. The novel, selective, brain-penetrant neuropeptide Y Y2 receptor antagonist, JNJ-31020028, tested in animal models of alcohol consumption, relapse, and anxiety. Alcohol (Fayetteville, N.Y.). 45: 567-76. PMID 21145691 DOI: 10.1016/J.Alcohol.2010.09.003  0.604
2011 Breese GR, Sinha R, Heilig M. Chronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapse. Pharmacology & Therapeutics. 129: 149-71. PMID 20951730 DOI: 10.1016/J.Pharmthera.2010.09.007  0.411
2011 Heilig M, Warren KR, Kunos G, Silverman PB, Hewitt BG. Addiction research centres and the nurturing of creativity: the National Institute on Alcohol Abuse and Alcoholism. Addiction (Abingdon, England). 106: 1052-60. PMID 20569230 DOI: 10.1111/J.1360-0443.2010.02995.X  0.377
2011 Ramchandani VA, Umhau J, Pavon FJ, Ruiz-Velasco V, Margas W, Sun H, Damadzic R, Eskay R, Schoor M, Thorsell A, Schwandt ML, Sommer WH, George DT, Parsons LH, Herscovitch P, ... ... Heilig M, et al. A genetic determinant of the striatal dopamine response to alcohol in men. Molecular Psychiatry. 16: 809-17. PMID 20479755 DOI: 10.1038/Mp.2010.56  0.638
2010 Kallupi M, Cannella N, Economidou D, Ubaldi M, Ruggeri B, Weiss F, Massi M, Marugan J, Heilig M, Bonnavion P, de Lecea L, Ciccocioppo R. Neuropeptide S facilitates cue-induced relapse to cocaine seeking through activation of the hypothalamic hypocretin system. Proceedings of the National Academy of Sciences of the United States of America. 107: 19567-72. PMID 20974945 DOI: 10.1073/Pnas.1004100107  0.664
2010 Umhau JC, Momenan R, Schwandt ML, Singley E, Lifshitz M, Doty L, Adams LJ, Vengeliene V, Spanagel R, Zhang Y, Shen J, George DT, Hommer D, Heilig M. Effect of acamprosate on magnetic resonance spectroscopy measures of central glutamate in detoxified alcohol-dependent individuals: a randomized controlled experimental medicine study. Archives of General Psychiatry. 67: 1069-77. PMID 20921123 DOI: 10.1001/Archgenpsychiatry.2010.125  0.382
2010 Cippitelli A, Zook M, Bell L, Damadzic R, Eskay RL, Schwandt M, Heilig M. Reversibility of object recognition but not spatial memory impairment following binge-like alcohol exposure in rats. Neurobiology of Learning and Memory. 94: 538-46. PMID 20849966 DOI: 10.1016/J.Nlm.2010.09.006  0.322
2010 Lindell SG, Schwandt ML, Sun H, Sparenborg JD, Björk K, Kasckow JW, Sommer WH, Goldman D, Higley JD, Suomi SJ, Heilig M, Barr CS. Functional NPY variation as a factor in stress resilience and alcohol consumption in rhesus macaques. Archives of General Psychiatry. 67: 423-31. PMID 20368518 DOI: 10.1001/Archgenpsychiatry.2010.23  0.407
2010 Hansson AC, Nixon K, Rimondini R, Damadzic R, Sommer WH, Eskay R, Crews FT, Heilig M. Long-term suppression of forebrain neurogenesis and loss of neuronal progenitor cells following prolonged alcohol dependence in rats. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 13: 583-93. PMID 20334723 DOI: 10.1017/S1461145710000246  0.382
2010 Heilig M, Egli M, Crabbe JC, Becker HC. Acute withdrawal, protracted abstinence and negative affect in alcoholism: are they linked? Addiction Biology. 15: 169-84. PMID 20148778 DOI: 10.1111/J.1369-1600.2009.00194.X  0.412
2010 Leeman RF, Heilig M, Cunningham CL, Stephens DN, Duka T, O'Malley SS. Ethanol consumption: how should we measure it? Achieving consilience between human and animal phenotypes. Addiction Biology. 15: 109-24. PMID 20148775 DOI: 10.1111/J.1369-1600.2009.00192.X  0.368
2010 Schwandt ML, Lindell SG, Chen S, Higley JD, Suomi SJ, Heilig M, Barr CS. Alcohol response and consumption in adolescent rhesus macaques: life history and genetic influences. Alcohol (Fayetteville, N.Y.). 44: 67-80. PMID 20113875 DOI: 10.1016/J.Alcohol.2009.09.034  0.572
2010 Thorsell A, Schank JR, Singley E, Hunt SP, Heilig M. Neurokinin-1 receptors (NK1R:s), alcohol consumption, and alcohol reward in mice. Psychopharmacology. 209: 103-11. PMID 20112009 DOI: 10.1007/S00213-010-1775-1  0.412
2010 Heilig M, Thorsell A, Sommer WH, Hansson AC, Ramchandani VA, George DT, Hommer D, Barr CS. Translating the neuroscience of alcoholism into clinical treatments: from blocking the buzz to curing the blues. Neuroscience and Biobehavioral Reviews. 35: 334-44. PMID 19941895 DOI: 10.1016/J.Neubiorev.2009.11.018  0.43
2010 George DT, Herion DW, Jones CL, Phillips MJ, Hersh J, Hill D, Heilig M, Ramchandani VA, Geyer C, Spero DE, Singley ED, O'Malley SS, Bishai R, Rawlings RR, Kunos G. Rimonabant (SR141716) has no effect on alcohol self-administration or endocrine measures in nontreatment-seeking heavy alcohol drinkers. Psychopharmacology. 208: 37-44. PMID 19902183 DOI: 10.1007/S00213-009-1704-3  0.403
2010 Barr CS, Chen SA, Schwandt ML, Lindell SG, Sun H, Suomi SJ, Heilig M. Suppression of alcohol preference by naltrexone in the rhesus macaque: a critical role of genetic variation at the micro-opioid receptor gene locus. Biological Psychiatry. 67: 78-80. PMID 19748082 DOI: 10.1016/J.Biopsych.2009.07.026  0.564
2009 Ciccocioppo R, Gehlert DR, Ryabinin A, Kaur S, Cippitelli A, Thorsell A, Lê AD, Hipskind PA, Hamdouchi C, Lu J, Hembre EJ, Cramer J, Song M, McKinzie D, Morin M, ... ... Heilig M, et al. Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond. Alcohol (Fayetteville, N.Y.). 43: 491-8. PMID 19913192 DOI: 10.1016/J.Alcohol.2009.08.003  0.603
2009 Pickens CL, Adams-Deutsch T, Nair SG, Navarre BM, Heilig M, Shaham Y. Effect of pharmacological manipulations of neuropeptide Y and corticotropin-releasing factor neurotransmission on incubation of conditioned fear. Neuroscience. 164: 1398-406. PMID 19800945 DOI: 10.1016/J.Neuroscience.2009.09.079  0.304
2009 Barr CS, Dvoskin RL, Gupte M, Sommer W, Sun H, Schwandt ML, Lindell SG, Kasckow JW, Suomi SJ, Goldman D, Higley JD, Heilig M. Functional CRH variation increases stress-induced alcohol consumption in primates. Proceedings of the National Academy of Sciences of the United States of America. 106: 14593-8. PMID 19706546 DOI: 10.1073/Pnas.0902863106  0.387
2009 Jerlhag E, Egecioglu E, Landgren S, Salomé N, Heilig M, Moechars D, Datta R, Perrissoud D, Dickson SL, Engel JA. Requirement of central ghrelin signaling for alcohol reward. Proceedings of the National Academy of Sciences of the United States of America. 106: 11318-23. PMID 19564604 DOI: 10.1073/Pnas.0812809106  0.393
2009 Cannella N, Economidou D, Kallupi M, Stopponi S, Heilig M, Massi M, Ciccocioppo R. Persistent increase of alcohol-seeking evoked by neuropeptide S: an effect mediated by the hypothalamic hypocretin system. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 2125-34. PMID 19322167 DOI: 10.1038/Npp.2009.37  0.492
2009 Momenan R, Kerich M, Van K, Zhang Y, Hommer D, Heilig M. Relationship Between Cerebral Glutamate and the Brain Volume in Alcoholic Subjects Neuroimage. 47: S154. DOI: 10.1016/S1053-8119(09)71606-4  0.335
2008 Barr CS, Dvoskin RL, Yuan Q, Lipsky RH, Gupte M, Hu X, Zhou Z, Schwandt ML, Lindell SG, McKee M, Becker ML, Kling MA, Gold PW, Higley D, Heilig M, et al. CRH haplotype as a factor influencing cerebrospinal fluid levels of corticotropin-releasing hormone, hypothalamic-pituitary-adrenal axis activity, temperament, and alcohol consumption in rhesus macaques. Archives of General Psychiatry. 65: 934-44. PMID 18678798 DOI: 10.1001/Archpsyc.65.8.934  0.388
2008 Economidou D, Hansson AC, Weiss F, Terasmaa A, Sommer WH, Cippitelli A, Fedeli A, Martin-Fardon R, Massi M, Ciccocioppo R, Heilig M. Dysregulation of nociceptin/orphanin FQ activity in the amygdala is linked to excessive alcohol drinking in the rat. Biological Psychiatry. 64: 211-8. PMID 18367152 DOI: 10.1016/J.Biopsych.2008.02.004  0.723
2008 George DT, Gilman J, Hersh J, Thorsell A, Herion D, Geyer C, Peng X, Kielbasa W, Rawlings R, Brandt JE, Gehlert DR, Tauscher JT, Hunt SP, Hommer D, Heilig M. Neurokinin 1 receptor antagonism as a possible therapy for alcoholism. Science (New York, N.Y.). 319: 1536-9. PMID 18276852 DOI: 10.1126/Science.1153813  0.424
2008 Huang J, Young B, Pletcher MT, Heilig M, Wahlestedt C. Association between the nociceptin receptor gene (OPRL1) single nucleotide polymorphisms and alcohol dependence. Addiction Biology. 13: 88-94. PMID 18269382 DOI: 10.1111/J.1369-1600.2007.00089.X  0.365
2008 Karlsson RM, Choe JS, Cameron HA, Thorsell A, Crawley JN, Holmes A, Heilig M. The neuropeptide Y Y1 receptor subtype is necessary for the anxiolytic-like effects of neuropeptide Y, but not the antidepressant-like effects of fluoxetine, in mice. Psychopharmacology. 195: 547-57. PMID 17891380 DOI: 10.1007/S00213-007-0945-2  0.301
2008 Kakko J, von Wachenfeldt J, Svanborg KD, Lidström J, Barr CS, Heilig M. Mood and neuroendocrine response to a chemical stressor, metyrapone, in buprenorphine-maintained heroin dependence. Biological Psychiatry. 63: 172-7. PMID 17850768 DOI: 10.1016/J.Biopsych.2007.05.001  0.306
2008 Sommer WH, Rimondini R, Hansson AC, Hipskind PA, Gehlert DR, Barr CS, Heilig MA. Upregulation of voluntary alcohol intake, behavioral sensitivity to stress, and amygdala crhr1 expression following a history of dependence. Biological Psychiatry. 63: 139-45. PMID 17585886 DOI: 10.1016/j.biopsych.2007.01.010  0.307
2007 Heilig M, Koob GF. A key role for corticotropin-releasing factor in alcohol dependence. Trends in Neurosciences. 30: 399-406. PMID 17629579 DOI: 10.1016/J.Tins.2007.06.006  0.629
2007 Hansson AC, Cippitelli A, Sommer WH, Ciccocioppo R, Heilig M. Region-specific down-regulation of Crhr1 gene expression in alcohol-preferring msP rats following ad lib access to alcohol. Addiction Biology. 12: 30-4. PMID 17407495 DOI: 10.1111/J.1369-1600.2007.00050.X  0.492
2007 Gehlert DR, Cippitelli A, Thorsell A, Lê AD, Hipskind PA, Hamdouchi C, Lu J, Hembre EJ, Cramer J, Song M, McKinzie D, Morin M, Ciccocioppo R, Heilig M. 3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine: a novel brain-penetrant, orally available corticotropin-releasing factor receptor 1 antagonist with efficacy in animal models of alcoholism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 2718-26. PMID 17344409 DOI: 10.1523/Jneurosci.4985-06.2007  0.492
2007 Barr CS, Schwandt M, Lindell SG, Chen SA, Goldman D, Suomi SJ, Higley JD, Heilig M. Association of a functional polymorphism in the mu-opioid receptor gene with alcohol response and consumption in male rhesus macaques. Archives of General Psychiatry. 64: 369-76. PMID 17339526 DOI: 10.1001/Archpsyc.64.3.369  0.585
2007 Ciccocioppo R, Economidou D, Rimondini R, Sommer W, Massi M, Heilig M. Buprenorphine reduces alcohol drinking through activation of the nociceptin/orphanin FQ-NOP receptor system. Biological Psychiatry. 61: 4-12. PMID 16533497 DOI: 10.1016/J.Biopsych.2006.01.006  0.492
2007 Ciccocioppo R, Heilig M. Reply Biological Psychiatry. 62: 702. DOI: 10.1016/j.biopsych.2007.02.013  0.428
2006 Hansson AC, Cippitelli A, Sommer WH, Fedeli A, Björk K, Soverchia L, Terasmaa A, Massi M, Heilig M, Ciccocioppo R. Variation at the rat Crhr1 locus and sensitivity to relapse into alcohol seeking induced by environmental stress. Proceedings of the National Academy of Sciences of the United States of America. 103: 15236-41. PMID 17015825 DOI: 10.1073/Pnas.0604419103  0.492
2006 Heilig M, Egli M. Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms. Pharmacology & Therapeutics. 111: 855-76. PMID 16545872 DOI: 10.1016/J.Pharmthera.2006.02.001  0.4
2005 Mottagui-Tabar S, Prince JA, Wahlestedt C, Zhu G, Goldman D, Heilig M. A novel single nucleotide polymorphism of the neuropeptide Y (NPY) gene associated with alcohol dependence. Alcoholism, Clinical and Experimental Research. 29: 702-7. PMID 15897713 DOI: 10.1097/01.Alc.0000164365.04961.B1  0.379
2005 Cippitelli A, Bilbao A, Hansson AC, del Arco I, Sommer W, Heilig M, Massi M, Bermúdez-Silva FJ, Navarro M, Ciccocioppo R, de Fonseca FR. Cannabinoid CB1 receptor antagonism reduces conditioned reinstatement of ethanol-seeking behavior in rats. The European Journal of Neuroscience. 21: 2243-51. PMID 15869521 DOI: 10.1111/J.1460-9568.2005.04056.X  0.428
2005 Karlsson RM, Holmes A, Heilig M, Crawley JN. Anxiolytic-like actions of centrally-administered neuropeptide Y, but not galanin, in C57BL/6J mice. Pharmacology, Biochemistry, and Behavior. 80: 427-36. PMID 15740785 DOI: 10.1016/J.Pbb.2004.12.009  0.314
2005 Bart G, Kreek MJ, Ott J, LaForge KS, Proudnikov D, Pollak L, Heilig M. Increased attributable risk related to a functional mu-opioid receptor gene polymorphism in association with alcohol dependence in central Sweden. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 30: 417-22. PMID 15525999 DOI: 10.1038/Sj.Npp.1300598  0.403
2004 Kalisch R, Salomé N, Platzer S, Wigger A, Czisch M, Sommer W, Singewald N, Heilig M, Berthele A, Holsboer F, Landgraf R, Auer DP. High trait anxiety and hyporeactivity to stress of the dorsomedial prefrontal cortex: a combined phMRI and Fos study in rats. Neuroimage. 23: 382-91. PMID 15325386 DOI: 10.1016/J.Neuroimage.2004.06.012  0.326
2004 Mottagui-Tabar S, McCarthy S, Reinemund J, Andersson B, Wahlestedt C, Heilig M. Analysis of 5-hydroxytryptamine 2c receptor gene promoter variants as alcohol-dependence risk factors. Alcohol and Alcoholism (Oxford, Oxfordshire). 39: 380-5. PMID 15304380 DOI: 10.1093/Alcalc/Agh086  0.381
2004 Ciccocioppo R, Economidou D, Fedeli A, Angeletti S, Weiss F, Heilig M, Massi M. Attenuation of ethanol self-administration and of conditioned reinstatement of alcohol-seeking behaviour by the antiopioid peptide nociceptin/orphanin FQ in alcohol-preferring rats. Psychopharmacology. 172: 170-8. PMID 14624331 DOI: 10.1007/S00213-003-1645-1  0.729
2004 Ciccocioppo R, Cippitelli A, Soverchia L, Ubaldi M, Heilig M, Sommer W, Arlinde C, Hansson A, Hyytia P, Fonseca Fd, Massi M. P13 FUNCTIONAL GENOMICS FOR TARGET GENE IDENTIFICATION IN ANIMAL MODELS OF ALCOHOL ABUSE: THE ROLE OF THE CANNABINOID CB1 RECEPTOR SYSTEM Behavioural Pharmacology. 15: A11-A12. DOI: 10.1097/00008877-200409000-00053  0.492
2004 Fedeli A, Hansson A, Heilig M, Economidou D, Massi M, Ciccocioppo R. THE NOCICEPTIN/ORPHANIN FQ SYSTEM IS DIFFERENTIALLY REGULATED IN GENETICALLY SELECTED ALCOHOL PREFERRING MSP COMPARED TO WISTAR RATS. Alcoholism: Clinical & Experimental Research. 28: 17A. DOI: 10.1097/00000374-200408002-00064  0.492
2003 Holmes A, Heilig M, Rupniak NM, Steckler T, Griebel G. Neuropeptide systems as novel therapeutic targets for depression and anxiety disorders. Trends in Pharmacological Sciences. 24: 580-8. PMID 14607081 DOI: 10.1016/J.Tips.2003.09.011  0.316
2003 Kela J, Salmi P, Rimondini-Giorgini R, Heilig M, Wahlestedt C. Behavioural analysis of melanin-concentrating hormone in rats: evidence for orexigenic and anxiolytic properties. Regulatory Peptides. 114: 109-14. PMID 12832098 DOI: 10.1016/S0167-0115(03)00114-9  0.315
2003 Pandey SC, Carr LG, Heilig M, Ilveskoski E, Thiele TE. Neuropeptide y and alcoholism: genetic, molecular, and pharmacological evidence. Alcoholism, Clinical and Experimental Research. 27: 149-54. PMID 12605064 DOI: 10.1097/01.Alc.0000052706.21367.0E  0.404
2003 Zhu G, Pollak L, Mottagui-Tabar S, Wahlestedt C, Taubman J, Virkkunen M, Goldman D, Heilig M. NPY Leu7Pro and alcohol dependence in Finnish and Swedish populations. Alcoholism, Clinical and Experimental Research. 27: 19-24. PMID 12544000 DOI: 10.1111/J.1530-0277.2003.Tb02715.X  0.387
1994 Heilig M, Koob GF, Ekman R, Britton KT. Corticotropin-releasing factor and neuropeptide Y: role in emotional integration. Trends in Neurosciences. 17: 80-5. PMID 7512773 DOI: 10.1016/0166-2236(94)90079-5  0.551
1993 Pich EM, Koob GF, Heilig M, Menzaghi F, Vale W, Weiss F. Corticotropin-releasing factor release from the mediobasal hypothalamus of the rat as measured by microdialysis. Neuroscience. 55: 695-707. PMID 8413932 DOI: 10.1016/0306-4522(93)90435-I  0.673
1993 Wahlestedt C, Pich EM, Koob GF, Yee F, Heilig M. Modulation of anxiety and neuropeptide Y-Y1 receptors by antisense oligodeoxynucleotides. Science (New York, N.Y.). 259: 528-31. PMID 8380941 DOI: 10.1126/Science.8380941  0.563
1993 Heilig M, McLeod S, Brot M, Heinrichs SC, Menzaghi F, Koob GF, Britton KT. Anxiolytic-like action of neuropeptide Y: mediation by Y1 receptors in amygdala, and dissociation from food intake effects. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 8: 357-63. PMID 8099792 DOI: 10.1038/Npp.1993.35  0.702
1993 Bing O, Möller C, Engel JA, Söderpalm B, Heilig M. Anxiolytic-like action of centrally administered galanin. Neuroscience Letters. 164: 17-20. PMID 7512244 DOI: 10.1016/0304-3940(93)90846-D  0.346
1991 Heilig M, Edvinsson L, Wahlestedt C. Effects of intracerebroventricular D-myo-inositol-1,2,6-trisphosphate (PP56), a proposed neuropeptide Y (NPY) antagonist, on locomotor activity, food intake, central effects of NPY and NPY-receptor binding. European Journal of Pharmacology. 209: 27-32. PMID 1667639 DOI: 10.1016/0014-2999(91)90006-C  0.323
1990 Wahlestedt C, Grundemar L, HÃ¥kanson R, Heilig M, Shen GH, Zukowska-Grojec Z, Reis DJ. Neuropeptide Y receptor subtypes, Y1 and Y2. Annals of the New York Academy of Sciences. 611: 7-26. PMID 2174225 DOI: 10.1111/J.1749-6632.1990.Tb48918.X  0.304
1989 Heilig M, Söderpalm B, Engel JA, Widerlöv E. Centrally administered neuropeptide Y (NPY) produces anxiolytic-like effects in animal anxiety models. Psychopharmacology. 98: 524-9. PMID 2570434 DOI: 10.1007/Bf00441953  0.327
1988 Heilig M, Wahlestedt C, Widerlöv E. Neuropeptide Y (NPY)-induced suppression of activity in the rat: evidence for NPY receptor heterogeneity and for interaction with alpha-adrenoceptors. European Journal of Pharmacology. 157: 205-13. PMID 2852114 DOI: 10.1016/0014-2999(88)90384-6  0.305
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