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Markus Heilig - Publications

Affiliations: 
National Institute on Alcohol Abuse and Alcoholism, North Bethesda, MD, United States 
Area:
Alcohol, behavioral pharmacology, target discovery and validation
Website:
http://www.niaaa.nih.gov/ResearchInformation/IntramuralResearch/AboutDICBR/LCTS/MP/
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252 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Heilig M, Augier E, Pfarr S, Sommer WH. Developing neuroscience-based treatments for alcohol addiction: A matter of choice? Translational Psychiatry. 9: 255. PMID 31594920 DOI: 10.1038/s41398-019-0591-6  0.64
2019 Mayo LM, Asratian A, Lindé J, Morena M, Haataja R, Hammar V, Augier G, Hill MN, Heilig M. Elevated Anandamide, Enhanced Recall of Fear Extinction, and Attenuated Stress Responses Following Inhibition of Fatty Acid Amide Hydrolase: A Randomized, Controlled Experimental Medicine Trial. Biological Psychiatry. PMID 31590924 DOI: 10.1016/j.biopsych.2019.07.034  1
2019 Perini I, Gustafsson PA, Hamilton JP, Kämpe R, Mayo LM, Heilig M, Zetterqvist M. Brain-based Classification of Negative Social Bias in Adolescents With Nonsuicidal Self-injury: Findings From Simulated Online Social Interaction. Eclinicalmedicine. 13: 81-90. PMID 31517265 DOI: 10.1016/j.eclinm.2019.06.016  1
2019 Johnstone AL, Andrade NS, Barbier E, Khomtchouk BB, Rienas CA, Lowe K, Van Booven DJ, Domi E, Esanov R, Vilca S, Tapocik JD, Rodriguez K, Maryanski D, Keogh MC, Meinhardt MW, ... ... Heilig M, et al. Dysregulation of the histone demethylase KDM6B in alcohol dependence is associated with epigenetic regulation of inflammatory signaling pathways. Addiction Biology. e12816. PMID 31373129 DOI: 10.1111/adb.12816  0.68
2019 Nelson BS, Fulenwider HD, Nennig SE, Smith BM, Sequeira MK, Chimberoff SH, Richie CT, Cheng K, Rice KC, Harvey BK, Heilig M, Schank JR. Escalated Alcohol Self-Administration and Sensitivity to Yohimbine-Induced Reinstatement in Alcohol Preferring Rats: Potential Role of Neurokinin-1 Receptors in the Amygdala. Neuroscience. PMID 31242442 DOI: 10.1016/j.neuroscience.2019.06.023  0.52
2019 Mayo LM, Heilig M. In the face of stress: Interpreting individual differences in stress-induced facial expressions. Neurobiology of Stress. 10: 100166. PMID 31193535 DOI: 10.1016/j.ynstr.2019.100166  1
2019 Spagnolo PA, Kimes A, Schwandt ML, Shokri-Kojori E, Thada S, Phillips KA, Diazgranados N, Preston KL, Herscovitch P, Tomasi D, Ramchandani VA, Heilig M. Striatal Dopamine Release in Response to Morphine: A [C]-Raclopride Positron Emission Tomography Study in Healthy Men. Biological Psychiatry. PMID 31097294 DOI: 10.1016/j.biopsych.2019.03.965  0.32
2019 Ree A, Morrison I, Olausson H, Sailer U, Heilig M, Mayo LM. Using Facial Electromyography to Assess Facial Muscle Reactions to Experienced and Observed Affective Touch in Humans. Journal of Visualized Experiments : Jove. PMID 30933066 DOI: 10.3791/59228  1
2019 Boehme R, Hauser S, Gerling GJ, Heilig M, Olausson H. Distinction of self-produced touch and social touch at cortical and spinal cord levels. Proceedings of the National Academy of Sciences of the United States of America. PMID 30670645 DOI: 10.1073/pnas.1816278116  0.32
2018 Mayo LM, Heilig M. A Hippocampal Signature of Posttraumatic Stress Disorder Vulnerability. Biological Psychiatry. 84: 78-79. PMID 31178061 DOI: 10.1016/j.biopsych.2018.04.015  1
2018 Epstein DH, Heilig M, Shaham Y. Science-Based Actions Can Help Address the Opioid Crisis. Trends in Pharmacological Sciences. 39: 911-916. PMID 30343726 DOI: 10.1016/j.tips.2018.06.002  0.52
2018 Mayo LM, Asratian A, Lindé J, Holm L, Nätt D, Augier G, Stensson N, Vecchiarelli HA, Balsevich G, Aukema RJ, Ghafouri B, Spagnolo PA, Lee FS, Hill MN, Heilig M. Protective effects of elevated anandamide on stress and fear-related behaviors: translational evidence from humans and mice. Molecular Psychiatry. PMID 30120421 DOI: 10.1038/s41380-018-0215-1  1
2018 Mayo LM, Lindé J, Olausson H, Heilig M, Morrison I. Putting a good face on touch: Facial expression reflects the affective valence of caress-like touch across modalities. Biological Psychology. PMID 30003943 DOI: 10.1016/j.biopsycho.2018.07.001  1
2018 Augier E, Barbier E, Dulman RS, Licheri V, Augier G, Domi E, Barchiesi R, Farris S, Nätt D, Mayfield RD, Adermark L, Heilig M. A molecular mechanism for choosing alcohol over an alternative reward. Science (New York, N.Y.). 360: 1321-1326. PMID 29930131 DOI: 10.1126/science.aao1157  0.68
2018 Sequeira MK, Nelson BS, Fulenwider HD, King CE, Nennig SE, Bohannon JB, Cheng K, Rice KC, Heilig M, Schank JR. The neurokinin-1 receptor mediates escalated alcohol intake induced by multiple drinking models. Neuropharmacology. 137: 194-201. PMID 29758386 DOI: 10.1016/j.neuropharm.2018.05.005  0.52
2018 Lee JS, Sorcher JL, Rosen AD, Damadzic R, Sun H, Schwandt M, Heilig M, Kelly J, Mauro KL, Luo A, Rosoff D, Muench C, Jung J, Kaminsky ZA, Lohoff FW. Genetic Association and Expression Analyses of the Phosphatidylinositol-4-Phosphate 5-Kinase (PIP5K1C) Gene in Alcohol Use Disorder - Relevance for Pain Signaling and Alcohol Use. Alcoholism, Clinical and Experimental Research. PMID 29667742 DOI: 10.1111/acer.13751  0.48
2018 Stojakovic A, Walczak M, Cieślak PE, Trenk A, Sköld J, Zajdel J, Mirrasekhian E, Karlsson C, Thorsell A, Heilig M, Parkitna JR, Błasiak T, Engblom D. Several behavioral traits relevant for alcoholism are controlled by ɣ2 subunit containing GABAreceptors on dopamine neurons in mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 29463910 DOI: 10.1038/s41386-018-0022-z  0.68
2018 Van Hedger K, Keedy SK, Mayo LM, Heilig M, de Wit H. Neural responses to cues paired with methamphetamine in healthy volunteers. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 29463908 DOI: 10.1038/s41386-017-0005-5  1
2017 Baker M, Lindell SG, Driscoll CA, Zhou Z, Yuan Q, Schwandt ML, Miller-Crews I, Simpson EA, Paukner A, Ferrari PF, Sindhu RK, Razaqyar M, Sommer WH, Lopez JF, Thompson RC, ... ... Heilig M, et al. Early rearing history influences oxytocin receptor epigenetic regulation in rhesus macaques. Proceedings of the National Academy of Sciences of the United States of America. PMID 29078292 DOI: 10.1073/pnas.1706206114  0.48
2017 Schank JR, Heilig M. Substance P and the Neurokinin-1 Receptor: The New CRF. International Review of Neurobiology. 136: 151-175. PMID 29056150 DOI: 10.1016/bs.irn.2017.06.008  0.52
2017 Augier E, Dulman RS, Damadzic R, Pilling A, Hamilton JP, Heilig M. The GABAB Positive Allosteric Modulator, ADX71441 Attenuates Alcohol Self-Administration and Relapse to Alcohol Seeking in Rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 28294133 DOI: 10.1038/npp.2017.53  0.64
2017 Augier E, Dulman RS, Singley E, Heilig M. A Method for Evaluating the Reinforcing Properties of Ethanol in Rats without Water Deprivation, Saccharin Fading or Extended Access Training. Journal of Visualized Experiments : Jove. PMID 28190044 DOI: 10.3791/53305  0.64
2016 Domi E, Uhrig S, Soverchia L, Spanagel R, Hansson AC, Barbier E, Heilig M, Ciccocioppo R, Ubaldi M. Genetic deletion of neuronal PPARγ enhances the emotional response to acute stress and exacerbates anxiety: An effect reversed by rescue of amygdala PPARγ function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 27810934 DOI: 10.1523/JNEUROSCI.4127-15.2016  0.8
2016 Spagnolo PA, Ramchandani VA, Schwandt ML, Kwako LE, George DT, Mayo LM, Hillard CJ, Heilig M. FAAH Gene Variation Moderates Stress Response and Symptom Severity in Patients with Posttraumatic Stress Disorder and Comorbid Alcohol Dependence. Alcoholism, Clinical and Experimental Research. PMID 27716956 DOI: 10.1111/acer.13210  1
2016 Heilig M, Barbier E, Johnstone AL, Tapocik J, Meinhardt MW, Pfarr S, Wahlestedt CR, Sommer WH. Reprogramming of mPFC transcriptome and function in alcohol dependence. Genes, Brain, and Behavior. PMID 27657733 DOI: 10.1111/gbb.12344  0.48
2016 Karlsson C, Rehman F, Damadzic R, Atkins AL, Schank JR, Gehlert DR, Steensland P, Thorsell A, Heilig M. Erratum to: The melanin-concentrating hormone-1 receptor modulates alcohol-induced reward and DARPP-32 phosphorylation. Psychopharmacology. PMID 27650828 DOI: 10.1007/s00213-016-4434-3  0.68
2016 Epstein DH, Kennedy AP, Furnari M, Heilig M, Shaham Y, Phillips KA, Preston KL. Effect of the CRF1-receptor antagonist pexacerfont on stress-induced eating and food craving. Psychopharmacology. PMID 27595147 DOI: 10.1007/s00213-016-4424-5  1
2016 Karlsson C, Aziz AM, Rehman F, Pitcairn C, Barchiesi R, Barbier E, Wendel Hansen M, Gehlert D, Steensland P, Heilig M, Thorsell A. Melanin-Concentrating Hormone and Its MCH-1 Receptor: Relationship Between Effects on Alcohol and Caloric Intake. Alcoholism, Clinical and Experimental Research. PMID 27579857 DOI: 10.1111/acer.13181  0.68
2016 Aziz AM, Brothers S, Sartor G, Holm L, Heilig M, Wahlestedt C, Thorsell A. The nociceptin/orphanin FQ receptor agonist SR-8993 as a candidate therapeutic for alcohol use disorders: validation in rat models. Psychopharmacology. PMID 27515665 DOI: 10.1007/s00213-016-4385-8  0.68
2016 Driscoll CA, Lindell SG, Schwandt ML, Suomi SJ, Higley JD, Heilig M, Barr CS. OPRM1 genotype interacts with serotonin system dysfunction to predict alcohol-heightened aggression in primates. Addiction Biology. PMID 27484010 DOI: 10.1111/adb.12428  1
2016 Augier E, Dulman RS, Rauffenbart C, Augier G, Cross AJ, Heilig M. The mGluR2 Positive Allosteric Modulator, AZD8529 and Cue-Induced Relapse to Alcohol Seeking in Rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27339394 DOI: 10.1038/npp.2016.107  0.64
2016 Heilig M, Epstein DH, Nader MA, Shaham Y. Time to connect: bringing social context into addiction neuroscience. Nature Reviews. Neuroscience. PMID 27277868 DOI: 10.1038/nrn.2016.67  1
2016 Karlsson C, Schank JR, Rehman F, Stojakovic A, Björk K, Barbier E, Solomon M, Tapocik J, Engblom D, Thorsell A, Heilig M. Proinflammatory signaling regulates voluntary alcohol intake and stress-induced consumption after exposure to social defeat stress in mice. Addiction Biology. PMID 27273552 DOI: 10.1111/adb.12416  0.68
2016 Heilig M, Sommer WH, Spanagel R. The Need for Treatment Responsive Translational Biomarkers in Alcoholism Research. Current Topics in Behavioral Neurosciences. PMID 27240677 DOI: 10.1007/7854_2015_5006  0.48
2016 Sells JR, Waters AJ, Schwandt ML, Kwako LE, Heilig M, George DT, Ramchandani VA. Characterization of comorbid PTSD in treatment-seeking alcohol dependent inpatients: Severity and personality trait differences. Drug and Alcohol Dependence. PMID 27114205 DOI: 10.1016/j.drugalcdep.2016.03.016  1
2016 Schwandt ML, Cortes CR, Kwako LE, George DT, Momenan R, Sinha R, Grigoriadis DE, Leggio L, Heilig M. The CRF1 Antagonist Verucerfont in Anxious Alcohol Dependent Women: Translation of Neuroendocrine, but not of Anti-Craving Effects. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27109623 DOI: 10.1038/npp.2016.61  1
2016 Gowin JL, Vatsalya V, Westman JG, Schwandt ML, Bartlett S, Heilig M, Momenan R, Ramchandani VA. The Effect of Varenicline on the Neural Processing of Fearful Faces and the Subjective Effects of Alcohol in Heavy Drinkers. Alcoholism, Clinical and Experimental Research. PMID 27062270 DOI: 10.1111/acer.13046  1
2016 Karlsson C, Rehman F, Damdazic R, Atkins AL, Schank JR, Gehlert DR, Steensland P, Thorsell A, Heilig M. The melanin-concentrating hormone-1 receptor modulates alcohol-induced reward and DARPP-32 phosphorylation. Psychopharmacology. PMID 27044354 DOI: 10.1007/s00213-016-4285-y  0.68
2016 Caruso V, Sreedharan S, Carlini VP, Jacobsson JA, Haitina T, Hammer J, Stephansson O, Crona F, Sommer WH, Risérus U, Lannfelt L, Marcus C, Heilig M, de Barioglio SR, Fredriksson R, et al. mRNA GPR162 changes are associated with decreased food intake in rat, and its human genetic variants with impairments in glucose homeostasis in two Swedish cohorts. Gene. PMID 26827797 DOI: 10.1016/j.gene.2016.01.044  1
2016 Heilig M, Leggio L. What the alcohol doctor ordered from the neuroscientist: Theragnostic biomarkers for personalized treatments. Progress in Brain Research. 224: 401-18. PMID 26822368 DOI: 10.1016/bs.pbr.2015.07.023  1
2015 Heilig M, Carlezon WA. Circumspectives: Cannabis and Psychiatric Illness: Blunt Thoughts. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26555278 DOI: 10.1038/npp.2015.321  1
2015 Herman MA, Varodayan FP, Oleata CS, Luu G, Kirson D, Heilig M, Ciccocioppo R, Roberto M. Glutamatergic transmission in the central nucleus of the amygdala is selectively altered in Marchigian Sardinian alcohol-preferring rats: Alcohol and CRF effects. Neuropharmacology. 102: 21-31. PMID 26519902 DOI: 10.1016/j.neuropharm.2015.10.027  1
2015 Ayanwuyi LO, Stopponi S, Ubaldi M, Cippitelli A, Nasuti C, Damadzic R, Heilig M, Schank J, Cheng K, Rice KC, Ciccocioppo R. Neurokinin 1 receptor blockade in the medial amygdala attenuates alcohol drinking in rats with innate anxiety but not in wistar rats. British Journal of Pharmacology. PMID 26275374 DOI: 10.1111/bph.13280  1
2015 Vatsalya V, Gowin JL, Schwandt ML, Momenan R, Coe MA, Cooke ME, Hommer DW, Bartlett S, Heilig M, Ramchandani VA. Effects of Varenicline on Neural Correlates of Alcohol Salience in Heavy Drinkers. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). PMID 26209857 DOI: 10.1093/ijnp/pyv068  1
2015 Schank JR, Nelson BS, Damadzic R, Tapocik JD, Yao M, King CE, Rowe KE, Cheng K, Rice KC, Heilig M. Neurokinin-1 receptor antagonism attenuates neuronal activity triggered by stress-induced reinstatement of alcohol seeking. Neuropharmacology. 99: 106-114. PMID 26188146 DOI: 10.1016/j.neuropharm.2015.07.009  0.52
2015 Suchankova P, Yan J, Schwandt ML, Stangl BL, Caparelli EC, Momenan R, Jerlhag E, Engel JA, Hodgkinson CA, Egli M, Lopez MF, Becker HC, Goldman D, Heilig M, Ramchandani VA, et al. The glucagon-like peptide-1 receptor as a potential treatment target in alcohol use disorder: evidence from human genetic association studies and a mouse model of alcohol dependence. Translational Psychiatry. 5: e583. PMID 26080318 DOI: 10.1038/tp.2015.68  0.32
2015 Heilig M, Carlezon WA. Circumspectives: The Replacements. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 1813-4. PMID 26068571 DOI: 10.1038/npp.2015.82  1
2015 Robinson JE, Vardy E, DiBerto JF, Chefer VI, White KL, Fish EW, Chen M, Gigante E, Krouse MC, Sun H, Thorsell A, Roth BL, Heilig M, Malanga CJ. Receptor Reserve Moderates Mesolimbic Responses to Opioids in a Humanized Mouse Model of the OPRM1 A118G Polymorphism. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 2614-22. PMID 25881115 DOI: 10.1038/npp.2015.109  1
2015 Barbier E, Tapocik JD, Juergens N, Pitcairn C, Borich A, Schank JR, Sun H, Schuebel K, Zhou Z, Yuan Q, Vendruscolo LF, Goldman D, Heilig M. DNA methylation in the medial prefrontal cortex regulates alcohol-induced behavior and plasticity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 6153-64. PMID 25878287 DOI: 10.1523/JNEUROSCI.4571-14.2015  1
2015 Spagnolo PA, Colloca L, Heilig M. The role of expectation in the therapeutic outcomes of alcohol and drug addiction treatments. Alcohol and Alcoholism (Oxford, Oxfordshire). 50: 282-5. PMID 25761920 DOI: 10.1093/alcalc/agv015  1
2015 de Guglielmo G, Melis M, De Luca MA, Kallupi M, Li HW, Niswender K, Giordano A, Senzacqua M, Somaini L, Cippitelli A, Gaitanaris G, Demopulos G, Damadzic R, Tapocik J, Heilig M, et al. PPARc activation attenuates opioid consumption and modulates mesolimbic dopamine transmission. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 1052. PMID 25668637 DOI: 10.1038/npp.2014.305  0.8
2015 Bilbao A, Robinson JE, Heilig M, Malanga CJ, Spanagel R, Sommer WH, Thorsell A. A pharmacogenetic determinant of mu-opioid receptor antagonist effects on alcohol reward and consumption: evidence from humanized mice. Biological Psychiatry. 77: 850-8. PMID 25442002 DOI: 10.1016/j.biopsych.2014.08.021  1
2015 Kwako LE, Spagnolo PA, Schwandt ML, Thorsell A, George DT, Momenan R, Rio DE, Huestis M, Anizan S, Concheiro M, Sinha R, Heilig M. The corticotropin releasing hormone-1 (CRH1) receptor antagonist pexacerfont in alcohol dependence: a randomized controlled experimental medicine study. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 1053-63. PMID 25409596 DOI: 10.1038/npp.2014.306  1
2015 Schmeichel BE, Barbier E, Misra KK, Contet C, Schlosburg JE, Grigoriadis D, Williams JP, Karlsson C, Pitcairn C, Heilig M, Koob GF, Vendruscolo LF. Hypocretin receptor 2 antagonism dose-dependently reduces escalated heroin self-administration in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 1123-9. PMID 25367502 DOI: 10.1038/npp.2014.293  1
2015 Senatorov VV, Damadzic R, Mann CL, Schwandt ML, George DT, Hommer DW, Heilig M, Momenan R. Reduced anterior insula, enlarged amygdala in alcoholism and associated depleted von Economo neurons. Brain : a Journal of Neurology. 138: 69-79. PMID 25367022 DOI: 10.1093/brain/awu305  0.48
2015 de Guglielmo G, Melis M, De Luca MA, Kallupi M, Li HW, Niswender K, Giordano A, Senzacqua M, Somaini L, Cippitelli A, Gaitanaris G, Demopulos G, Damadzic R, Tapocik J, Heilig M, et al. PPARγ activation attenuates opioid consumption and modulates mesolimbic dopamine transmission. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 927-37. PMID 25311134 DOI: 10.1038/npp.2014.268  1
2015 Cippitelli A, Ayanwuyi LO, Barbier E, Domi E, Lerma-Cabrera JM, Carvajal F, Scuppa G, Li H, Ubaldi M, Heilig M, Roberto M, Ciccocioppo R. Polymorphism in the corticotropin-releasing factor receptor 1 (CRF1-R) gene plays a role in shaping the high anxious phenotype of Marchigian Sardinian alcohol-preferring (msP) rats. Psychopharmacology. 232: 1083-93. PMID 25260340 DOI: 10.1007/s00213-014-3743-7  1
2015 Kwako LE, George DT, Schwandt ML, Spagnolo PA, Momenan R, Hommer DW, Diamond CA, Sinha R, Shaham Y, Heilig M. The neurokinin-1 receptor antagonist aprepitant in co-morbid alcohol dependence and posttraumatic stress disorder: a human experimental study. Psychopharmacology. 232: 295-304. PMID 25030801 DOI: 10.1007/s00213-014-3665-4  1
2015 Kwako LE, Schwandt ML, Sells JR, Ramchandani VA, Hommer DW, George DT, Sinha R, Heilig M. Methods for inducing alcohol craving in individuals with co-morbid alcohol dependence and posttraumatic stress disorder: behavioral and physiological outcomes. Addiction Biology. 20: 733-46. PMID 24806358 DOI: 10.1111/adb.12150  1
2015 Schank JR, Nelson BS, Damadzic R, Tapocik JD, Yao M, King CE, Rowe KE, Cheng K, Rice KC, Heilig M. Neurokinin-1 receptor antagonism attenuates neuronal activity triggered by stress-induced reinstatement of alcohol seeking Neuropharmacology. 99: 106-114. DOI: 10.1016/j.neuropharm.2015.07.009  1
2014 Spagnolo PA, Ramchandani VA, Schwandt ML, Zhang L, Blaine SK, Usala JM, Diamond KA, Phillips MJ, George DT, Momenan R, Heilig M. Effects of naltrexone on neural and subjective response to alcohol in treatment-seeking alcohol-dependent patients. Alcoholism, Clinical and Experimental Research. 38: 3024-32. PMID 25581657 DOI: 10.1111/acer.12581  1
2014 Heilig MA. Daniel W. Hommer. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 3128. PMID 25381706 DOI: 10.1038/npp.2014.249  1
2014 Ciccocioppo R, Stopponi S, Economidou D, Kuriyama M, Kinoshita H, Heilig M, Roberto M, Weiss F, Teshima K. Chronic treatment with novel brain-penetrating selective NOP receptor agonist MT-7716 reduces alcohol drinking and seeking in the rat. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 2601-10. PMID 24863033 DOI: 10.1038/npp.2014.113  1
2014 Augier E, Flanigan M, Dulman RS, Pincus A, Schank JR, Rice KC, Kejun C, Heilig M, Tapocik JD. Wistar rats acquire and maintain self-administration of 20 % ethanol without water deprivation, saccharin/sucrose fading, or extended access training. Psychopharmacology. 231: 4561-8. PMID 24858375 DOI: 10.1007/s00213-014-3605-3  1
2014 Heilig M, Schank JR. Kappa-opioid receptor antagonism: a mechanism for treatment of relief drinking? Biological Psychiatry. 75: 750-1. PMID 24780009 DOI: 10.1016/j.biopsych.2014.03.004  1
2014 Umhau JC, Schwandt M, Solomon MG, Yuan P, Nugent A, Zarate CA, Drevets WC, Hall SD, George DT, Heilig M. Cerebrospinal fluid monocyte chemoattractant protein-1 in alcoholics: support for a neuroinflammatory model of chronic alcoholism. Alcoholism, Clinical and Experimental Research. 38: 1301-6. PMID 24689518 DOI: 10.1111/acer.12367  1
2014 Tapocik JD, Barbier E, Flanigan M, Solomon M, Pincus A, Pilling A, Sun H, Schank JR, King C, Heilig M. microRNA-206 in rat medial prefrontal cortex regulates BDNF expression and alcohol drinking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 4581-8. PMID 24672003 DOI: 10.1523/JNEUROSCI.0445-14.2014  1
2014 Spanagel R, Noori HR, Heilig M. Stress and alcohol interactions: animal studies and clinical significance. Trends in Neurosciences. 37: 219-27. PMID 24636458 DOI: 10.1016/j.tins.2014.02.006  1
2014 Yong W, Spence JP, Eskay R, Fitz SD, Damadzic R, Lai D, Foroud T, Carr LG, Shekhar A, Chester JA, Heilig M, Liang T. Alcohol-preferring rats show decreased corticotropin-releasing hormone-2 receptor expression and differences in HPA activation compared to alcohol-nonpreferring rats. Alcoholism, Clinical and Experimental Research. 38: 1275-83. PMID 24611993 DOI: 10.1111/acer.12379  1
2014 Huang MC, Schwandt ML, Chester JA, Kirchhoff AM, Kao CF, Liang T, Tapocik JD, Ramchandani VA, George DT, Hodgkinson CA, Goldman D, Heilig M. FKBP5 moderates alcohol withdrawal severity: human genetic association and functional validation in knockout mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 2029-38. PMID 24603855 DOI: 10.1038/npp.2014.55  1
2014 Heilig M. Acamprosate: an alcoholism treatment that may not be what we thought. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 781-2. PMID 24518272 DOI: 10.1038/npp.2013.272  1
2014 Ciccocioppo R, de Guglielmo G, Hansson AC, Ubaldi M, Kallupi M, Cruz MT, Oleata CS, Heilig M, Roberto M. Restraint stress alters nociceptin/orphanin FQ and CRF systems in the rat central amygdala: significance for anxiety-like behaviors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 363-72. PMID 24403138 DOI: 10.1523/JNEUROSCI.2400-13.2014  1
2014 Lee MR, Cacic K, Demers CH, Haroon M, Heishman S, Hommer DW, Epstein DH, Ross TJ, Stein EA, Heilig M, Salmeron BJ. Gender differences in neural-behavioral response to self-observation during a novel fMRI social stress task. Neuropsychologia. 53: 257-63. PMID 24316200 DOI: 10.1016/j.neuropsychologia.2013.11.022  1
2014 Schank JR, King CE, Sun H, Cheng K, Rice KC, Heilig M, Weinshenker D, Schroeder JP. The role of the neurokinin-1 receptor in stress-induced reinstatement of alcohol and cocaine seeking. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 1093-101. PMID 24173499 DOI: 10.1038/npp.2013.309  1
2014 Cippitelli A, Damadzic R, Hamelink C, Brunnquell M, Thorsell A, Heilig M, Eskay RL. Binge-like ethanol consumption increases corticosterone levels and neurodegneration whereas occupancy of type II glucocorticoid receptors with mifepristone is neuroprotective. Addiction Biology. 19: 27-36. PMID 22500955 DOI: 10.1111/j.1369-1600.2012.00451.x  1
2013 Heilig M. [Opioid dependence: New national guidelines must allow maintenance treatment]. LäKartidningen. 110: 1908-9. PMID 24340431  1
2013 Patnaik S, Marugan JJ, Liu K, Zheng W, Southall N, Dehdashti SJ, Thorsell A, Heilig M, Bell L, Zook M, Eskay B, Brimacombe KR, Austin CP. Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide s receptor. Journal of Medicinal Chemistry. 56: 9045-56. PMID 24171469 DOI: 10.1021/jm400904m  1
2013 Zhou Z, Karlsson C, Liang T, Xiong W, Kimura M, Tapocik JD, Yuan Q, Barbier E, Feng A, Flanigan M, Augier E, Enoch MA, Hodgkinson CA, Shen PH, Lovinger DM, ... ... Heilig M, et al. Loss of metabotropic glutamate receptor 2 escalates alcohol consumption. Proceedings of the National Academy of Sciences of the United States of America. 110: 16963-8. PMID 24082084 DOI: 10.1073/pnas.1309839110  1
2013 Björk K, Tronci V, Thorsell A, Tanda G, Hirth N, Heilig M, Hansson AC, Sommer WH. β-Arrestin 2 knockout mice exhibit sensitized dopamine release and increased reward in response to a low dose of alcohol. Psychopharmacology. 230: 439-49. PMID 23779257 DOI: 10.1007/s00213-013-3166-x  1
2013 Thorsell A, Tapocik JD, Liu K, Zook M, Bell L, Flanigan M, Patnaik S, Marugan J, Damadzic R, Dehdashti SJ, Schwandt ML, Southall N, Austin CP, Eskay R, Ciccocioppo R, ... ... Heilig M, et al. A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 10132-42. PMID 23761908 DOI: 10.1523/JNEUROSCI.4742-12.2013  1
2013 Ayanwuyi LO, Carvajal F, Lerma-Cabrera JM, Domi E, Björk K, Ubaldi M, Heilig M, Roberto M, Ciccocioppo R, Cippitelli A. Role of a genetic polymorphism in the corticotropin-releasing factor receptor 1 gene in alcohol drinking and seeking behaviors of marchigian sardinian alcohol-preferring rats. Frontiers in Psychiatry. 4: 23. PMID 23630503 DOI: 10.3389/fpsyt.2013.00023  1
2013 Stopponi S, de Guglielmo G, Somaini L, Cippitelli A, Cannella N, Kallupi M, Ubaldi M, Heilig M, Demopulos G, Gaitanaris G, Ciccocioppo R. Activation of PPARγ by pioglitazone potentiates the effects of naltrexone on alcohol drinking and relapse in msP rats. Alcoholism, Clinical and Experimental Research. 37: 1351-60. PMID 23550625 DOI: 10.1111/acer.12091  1
2013 Schank JR, Tapocik JD, Barbier E, Damadzic R, Eskay RL, Sun H, Rowe KE, King CE, Yao M, Flanigan ME, Solomon MG, Karlsson C, Cheng K, Rice KC, Heilig M. Tacr1 gene variation and neurokinin 1 receptor expression is associated with antagonist efficacy in genetically selected alcohol-preferring rats. Biological Psychiatry. 73: 774-81. PMID 23419547 DOI: 10.1016/j.biopsych.2012.12.027  1
2013 Mayo LM, Fraser D, Childs E, Momenan R, Hommer DW, de Wit H, Heilig M. Conditioned preference to a methamphetamine-associated contextual cue in humans. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 921-9. PMID 23416857 DOI: 10.1038/npp.2013.3  1
2013 Meinhardt MW, Hansson AC, Perreau-Lenz S, Bauder-Wenz C, Stählin O, Heilig M, Harper C, Drescher KU, Spanagel R, Sommer WH. Rescue of infralimbic mGluR2 deficit restores control over drug-seeking behavior in alcohol dependence. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 2794-806. PMID 23407939 DOI: 10.1523/JNEUROSCI.4062-12.2013  1
2013 Umhau JC, George DT, Heaney RP, Lewis MD, Ursano RJ, Heilig M, Hibbeln JR, Schwandt ML. Low vitamin D status and suicide: a case-control study of active duty military service members. Plos One. 8: e51543. PMID 23308099 DOI: 10.1371/journal.pone.0051543  1
2013 Barbier E, Vendruscolo LF, Schlosburg JE, Edwards S, Juergens N, Park PE, Misra KK, Cheng K, Rice KC, Schank J, Schulteis G, Koob GF, Heilig M. The NK1 receptor antagonist L822429 reduces heroin reinforcement. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 976-84. PMID 23303056 DOI: 10.1038/npp.2012.261  1
2013 Zorrilla EP, Heilig M, de Wit H, Shaham Y. Behavioral, biological, and chemical perspectives on targeting CRF(1) receptor antagonists to treat alcoholism. Drug and Alcohol Dependence. 128: 175-86. PMID 23294766 DOI: 10.1016/j.drugalcdep.2012.12.017  1
2013 Schwandt ML, Heilig M, Hommer DW, George DT, Ramchandani VA. Childhood trauma exposure and alcohol dependence severity in adulthood: mediation by emotional abuse severity and neuroticism. Alcoholism, Clinical and Experimental Research. 37: 984-92. PMID 23278300 DOI: 10.1111/acer.12053  1
2013 Herman MA, Kallupi M, Luu G, Oleata CS, Heilig M, Koob GF, Ciccocioppo R, Roberto M. Enhanced GABAergic transmission in the central nucleus of the amygdala of genetically selected Marchigian Sardinian rats: alcohol and CRF effects. Neuropharmacology. 67: 337-48. PMID 23220399 DOI: 10.1016/j.neuropharm.2012.11.026  1
2013 Hirvonen J, Zanotti-Fregonara P, Umhau JC, George DT, Rallis-Frutos D, Lyoo CH, Li CT, Hines CS, Sun H, Terry GE, Morse C, Zoghbi SS, Pike VW, Innis RB, Heilig M. Reduced cannabinoid CB1 receptor binding in alcohol dependence measured with positron emission tomography. Molecular Psychiatry. 18: 916-21. PMID 22776901 DOI: 10.1038/mp.2012.100  1
2013 Tapocik JD, Solomon M, Flanigan M, Meinhardt M, Barbier E, Schank JR, Schwandt M, Sommer WH, Heilig M. Coordinated dysregulation of mRNAs and microRNAs in the rat medial prefrontal cortex following a history of alcohol dependence. The Pharmacogenomics Journal. 13: 286-96. PMID 22614244 DOI: 10.1038/tpj.2012.17  1
2013 Walsh SL, Heilig M, Nuzzo PA, Henderson P, Lofwall MR. Effects of the NK1 antagonist, aprepitant, on response to oral and intranasal oxycodone in prescription opioid abusers. Addiction Biology. 18: 332-43. PMID 22260216 DOI: 10.1111/j.1369-1600.2011.00419.x  1
2013 Bartlett S, Heilig M. Translational approaches to medication development. Current Topics in Behavioral Neurosciences. 13: 543-82. PMID 21590390 DOI: 10.1007/7854_2011_132  1
2012 Schank JR, Ryabinin AE, Giardino WJ, Ciccocioppo R, Heilig M. Stress-related neuropeptides and addictive behaviors: beyond the usual suspects. Neuron. 76: 192-208. PMID 23040815 DOI: 10.1016/j.neuron.2012.09.026  1
2012 Karlsson C, Zook M, Ciccocioppo R, Gehlert DR, Thorsell A, Heilig M, Cippitelli A. Melanin-concentrating hormone receptor 1 (MCH1-R) antagonism: reduced appetite for calories and suppression of addictive-like behaviors. Pharmacology, Biochemistry, and Behavior. 102: 400-6. PMID 22705492 DOI: 10.1016/j.pbb.2012.06.010  1
2012 Vendruscolo LF, Barbier E, Schlosburg JE, Misra KK, Whitfield TW, Logrip ML, Rivier C, Repunte-Canonigo V, Zorrilla EP, Sanna PP, Heilig M, Koob GF. Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 7563-71. PMID 22649234 DOI: 10.1523/JNEUROSCI.0069-12.2012  1
2012 Schank JR, Goldstein AL, Rowe KE, King CE, Marusich JA, Wiley JL, Carroll FI, Thorsell A, Heilig M. The kappa opioid receptor antagonist JDTic attenuates alcohol seeking and withdrawal anxiety. Addiction Biology. 17: 634-47. PMID 22515275 DOI: 10.1111/j.1369-1600.2012.00455.x  1
2012 Litten RZ, Egli M, Heilig M, Cui C, Fertig JB, Ryan ML, Falk DE, Moss H, Huebner R, Noronha A. Medications development to treat alcohol dependence: a vision for the next decade. Addiction Biology. 17: 513-27. PMID 22458728 DOI: 10.1111/j.1369-1600.2012.00454.x  1
2012 Huang MC, Schwandt ML, Ramchandani VA, George DT, Heilig M. Impact of multiple types of childhood trauma exposure on risk of psychiatric comorbidity among alcoholic inpatients. Alcoholism, Clinical and Experimental Research. 36: 1099-107. PMID 22420670 DOI: 10.1111/j.1530-0277.2011.01695.x  1
2012 Karlsson RM, Adermark L, Molander A, Perreau-Lenz S, Singley E, Solomon M, Holmes A, Tanaka K, Lovinger DM, Spanagel R, Heilig M. Reduced alcohol intake and reward associated with impaired endocannabinoid signaling in mice with a deletion of the glutamate transporter GLAST. Neuropharmacology. 63: 181-9. PMID 22342743 DOI: 10.1016/j.neuropharm.2012.01.027  1
2012 Spinelli S, Schwandt ML, Lindell SG, Heilig M, Suomi SJ, Higley JD, Goldman D, Barr CS. The serotonin transporter gene linked polymorphic region is associated with the behavioral response to repeated stress exposure in infant rhesus macaques. Development and Psychopathology. 24: 157-65. PMID 22293001 DOI: 10.1017/S0954579411000745  1
2012 Molander A, Vengeliene V, Heilig M, Wurst W, Deussing JM, Spanagel R. Brain-specific inactivation of the Crhr1 gene inhibits post-dependent and stress-induced alcohol intake, but does not affect relapse-like drinking. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 1047-56. PMID 22113086 DOI: 10.1038/npp.2011.297  1
2012 Cippitelli A, Damadzic R, Singley E, Thorsell A, Ciccocioppo R, Eskay RL, Heilig M. Pharmacological blockade of corticotropin-releasing hormone receptor 1 (CRH1R) reduces voluntary consumption of high alcohol concentrations in non-dependent Wistar rats. Pharmacology, Biochemistry, and Behavior. 100: 522-9. PMID 22036774 DOI: 10.1016/j.pbb.2011.10.016  1
2012 Chen CH, Walker J, Momenan R, Rawlings R, Heilig M, Hommer DW. Relationship between liver function and brain shrinkage in patients with alcohol dependence. Alcoholism, Clinical and Experimental Research. 36: 625-32. PMID 21995416 DOI: 10.1111/j.1530-0277.2011.01662.x  1
2012 Robinson JE, Fish EW, Krouse MC, Thorsell A, Heilig M, Malanga CJ. Potentiation of brain stimulation reward by morphine: effects of neurokinin-1 receptor antagonism. Psychopharmacology. 220: 215-24. PMID 21909635 DOI: 10.1007/s00213-011-2469-z  1
2012 Snell LD, Ramchandani VA, Saba L, Herion D, Heilig M, George DT, Pridzun L, Helander A, Schwandt ML, Phillips MJ, Hoffman PL, Tabakoff B. The biometric measurement of alcohol consumption. Alcoholism, Clinical and Experimental Research. 36: 332-41. PMID 21895709 DOI: 10.1111/j.1530-0277.2011.01605.x  1
2012 Magnusson Ã…, Lundholm C, Göransson M, Copeland W, Heilig M, Pedersen NL. Familial influence and childhood trauma in female alcoholism. Psychological Medicine. 42: 381-9. PMID 21798111 DOI: 10.1017/S0033291711001310  1
2012 Heilig M. Our focus on the pharmacogenetics of CRF 1 antagonists is simply because they are in clinical development Nature Reviews Neuroscience. 13: 70. DOI: 10.1038/nrn3110-c2  1
2012 Heilig M. Svaga argument mot en restriktiv narkotikapolitik Lakartidningen. 109.  1
2011 Heilig M, Goldman D, Berrettini W, O'Brien CP. Pharmacogenetic approaches to the treatment of alcohol addiction. Nature Reviews. Neuroscience. 12: 670-84. PMID 22011682 DOI: 10.1038/nrn3110  1
2011 Sreedharan S, Almén MS, Carlini VP, Haitina T, Stephansson O, Sommer WH, Heilig M, de Barioglio SR, Fredriksson R, Schiöth HB. The G protein coupled receptor Gpr153 shares common evolutionary origin with Gpr162 and is highly expressed in central regions including the thalamus, cerebellum and the arcuate nucleus. The Febs Journal. 278: 4881-94. PMID 21981325 DOI: 10.1111/j.1742-4658.2011.08388.x  1
2011 Mahmoud S, Thorsell A, Sommer WH, Heilig M, Holgate JK, Bartlett SE, Ruiz-Velasco V. Pharmacological consequence of the A118G μ opioid receptor polymorphism on morphine- and fentanyl-mediated modulation of Ca²⁺ channels in humanized mouse sensory neurons. Anesthesiology. 115: 1054-62. PMID 21926562 DOI: 10.1097/ALN.0b013e318231fc11  1
2011 Sinha R, Shaham Y, Heilig M. Translational and reverse translational research on the role of stress in drug craving and relapse. Psychopharmacology. 218: 69-82. PMID 21494792 DOI: 10.1007/s00213-011-2263-y  1
2011 Heilig M. A welcome change that stops short of being fully satisfying. Addiction (Abingdon, England). 106: 874-5; discussion 89. PMID 21477231 DOI: 10.1111/j.1360-0443.2010.03233.x  1
2011 Schwandt ML, Lindell SG, Higley JD, Suomi SJ, Heilig M, Barr CS. OPRM1 gene variation influences hypothalamic-pituitary-adrenal axis function in response to a variety of stressors in rhesus macaques. Psychoneuroendocrinology. 36: 1303-11. PMID 21459516 DOI: 10.1016/j.psyneuen.2011.03.002  1
2011 Rinker JA, Hutchison MA, Chen SA, Thorsell A, Heilig M, Riley AL. Exposure to nicotine during periadolescence or early adulthood alters aversive and physiological effects induced by ethanol. Pharmacology, Biochemistry, and Behavior. 99: 7-16. PMID 21420998 DOI: 10.1016/j.pbb.2011.03.009  1
2011 Schank JR, Pickens CL, Rowe KE, Cheng K, Thorsell A, Rice KC, Shaham Y, Heilig M. Stress-induced reinstatement of alcohol-seeking in rats is selectively suppressed by the neurokinin 1 (NK1) antagonist L822429. Psychopharmacology. 218: 111-9. PMID 21340476 DOI: 10.1007/s00213-011-2201-z  1
2011 Copeland WE, Sun H, Costello EJ, Angold A, Heilig MA, Barr CS. Child μ-opioid receptor gene variant influences parent-child relations. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 1165-70. PMID 21326192 DOI: 10.1038/npp.2010.251  1
2011 Umhau JC, Schwandt ML, Usala J, Geyer C, Singley E, George DT, Heilig M. Pharmacologically induced alcohol craving in treatment seeking alcoholics correlates with alcoholism severity, but is insensitive to acamprosate. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 1178-86. PMID 21289601 DOI: 10.1038/npp.2010.253  1
2011 Stopponi S, Somaini L, Cippitelli A, Cannella N, Braconi S, Kallupi M, Ruggeri B, Heilig M, Demopulos G, Gaitanaris G, Massi M, Ciccocioppo R. Activation of nuclear PPARγ receptors by the antidiabetic agent pioglitazone suppresses alcohol drinking and relapse to alcohol seeking. Biological Psychiatry. 69: 642-9. PMID 21276964 DOI: 10.1016/j.biopsych.2010.12.010  1
2011 Hansson AC, Rimondini R, Heilig M, Mathé AA, Sommer WH. Dissociation of antidepressant-like activity of escitalopram and nortriptyline on behaviour and hippocampal BDNF expression in female rats. Journal of Psychopharmacology (Oxford, England). 25: 1378-87. PMID 21262856 DOI: 10.1177/0269881110393049  1
2011 Copeland WE, Magnusson A, Göransson M, Heilig MA. Genetic moderators and psychiatric mediators of the link between sexual abuse and alcohol dependence. Drug and Alcohol Dependence. 115: 183-9. PMID 21193270 DOI: 10.1016/j.drugalcdep.2010.10.024  1
2011 Cippitelli A, Rezvani AH, Robinson JE, Eisenberg L, Levin ED, Bonaventure P, Motley ST, Lovenberg TW, Heilig M, Thorsell A. The novel, selective, brain-penetrant neuropeptide Y Y2 receptor antagonist, JNJ-31020028, tested in animal models of alcohol consumption, relapse, and anxiety. Alcohol (Fayetteville, N.Y.). 45: 567-76. PMID 21145691 DOI: 10.1016/j.alcohol.2010.09.003  1
2011 Breese GR, Sinha R, Heilig M. Chronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapse. Pharmacology & Therapeutics. 129: 149-71. PMID 20951730 DOI: 10.1016/j.pharmthera.2010.09.007  1
2011 Heilig M, Warren KR, Kunos G, Silverman PB, Hewitt BG. Addiction research centres and the nurturing of creativity: the National Institute on Alcohol Abuse and Alcoholism. Addiction (Abingdon, England). 106: 1052-60. PMID 20569230 DOI: 10.1111/j.1360-0443.2010.02995.x  1
2011 Ramchandani VA, Umhau J, Pavon FJ, Ruiz-Velasco V, Margas W, Sun H, Damadzic R, Eskay R, Schoor M, Thorsell A, Schwandt ML, Sommer WH, George DT, Parsons LH, Herscovitch P, ... ... Heilig M, et al. A genetic determinant of the striatal dopamine response to alcohol in men. Molecular Psychiatry. 16: 809-17. PMID 20479755 DOI: 10.1038/mp.2010.56  1
2010 Blom ES, Wang Y, Skoglund L, Hansson AC, Ubaldi M, Lourdusamy A, Sommer WH, Mielke M, Hyman BT, Heilig M, Lannfelt L, Nilsson LN, Ingelsson M. Increased mRNA Levels of TCF7L2 and MYC of the Wnt Pathway in Tg-ArcSwe Mice and Alzheimer's Disease Brain. International Journal of Alzheimer's Disease. 2011: 936580. PMID 21234373 DOI: 10.4061/2011/936580  1
2010 McCoy JG, Marugan JJ, Liu K, Zheng W, Southall N, Huang W, Heilig M, Austin CP. Selective Modulation of Gq/Gs pathways by Naphtho Pyrano Pyrimidines as antagonists of the Neuropeptide S Receptor. Acs Chemical Neuroscience. 1: 559-574. PMID 21116448 DOI: 10.1021/cn100040h  1
2010 Kallupi M, Cannella N, Economidou D, Ubaldi M, Ruggeri B, Weiss F, Massi M, Marugan J, Heilig M, Bonnavion P, de Lecea L, Ciccocioppo R. Neuropeptide S facilitates cue-induced relapse to cocaine seeking through activation of the hypothalamic hypocretin system. Proceedings of the National Academy of Sciences of the United States of America. 107: 19567-72. PMID 20974945 DOI: 10.1073/pnas.1004100107  1
2010 Umhau JC, Momenan R, Schwandt ML, Singley E, Lifshitz M, Doty L, Adams LJ, Vengeliene V, Spanagel R, Zhang Y, Shen J, George DT, Hommer D, Heilig M. Effect of acamprosate on magnetic resonance spectroscopy measures of central glutamate in detoxified alcohol-dependent individuals: a randomized controlled experimental medicine study. Archives of General Psychiatry. 67: 1069-77. PMID 20921123 DOI: 10.1001/archgenpsychiatry.2010.125  1
2010 Cippitelli A, Zook M, Bell L, Damadzic R, Eskay RL, Schwandt M, Heilig M. Reversibility of object recognition but not spatial memory impairment following binge-like alcohol exposure in rats. Neurobiology of Learning and Memory. 94: 538-46. PMID 20849966 DOI: 10.1016/j.nlm.2010.09.006  1
2010 Sommer WH, Lidström J, Sun H, Passer D, Eskay R, Parker SC, Witt SH, Zimmermann US, Nieratschker V, Rietschel M, Margulies EH, Palkovits M, Laucht M, Heilig M. Human NPY promoter variation rs16147:T>C as a moderator of prefrontal NPY gene expression and negative affect. Human Mutation. 31: E1594-608. PMID 20648632 DOI: 10.1002/humu.21299  1
2010 Cippitelli A, Karlsson C, Shaw JL, Thorsell A, Gehlert DR, Heilig M. Suppression of alcohol self-administration and reinstatement of alcohol seeking by melanin-concentrating hormone receptor 1 (MCH1-R) antagonism in Wistar rats. Psychopharmacology. 211: 367-75. PMID 20628734 DOI: 10.1007/s00213-010-1891-y  1
2010 Björk K, Terasmaa A, Sun H, Thorsell A, Sommer WH, Heilig M. Ethanol-induced activation of AKT and DARPP-32 in the mouse striatum mediated by opioid receptors. Addiction Biology. 15: 299-303. PMID 20456289 DOI: 10.1111/j.1369-1600.2010.00212.x  1
2010 Lindell SG, Schwandt ML, Sun H, Sparenborg JD, Björk K, Kasckow JW, Sommer WH, Goldman D, Higley JD, Suomi SJ, Heilig M, Barr CS. Functional NPY variation as a factor in stress resilience and alcohol consumption in rhesus macaques. Archives of General Psychiatry. 67: 423-31. PMID 20368518 DOI: 10.1001/archgenpsychiatry.2010.23  1
2010 Hansson AC, Nixon K, Rimondini R, Damadzic R, Sommer WH, Eskay R, Crews FT, Heilig M. Long-term suppression of forebrain neurogenesis and loss of neuronal progenitor cells following prolonged alcohol dependence in rats. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 13: 583-93. PMID 20334723 DOI: 10.1017/S1461145710000246  1
2010 Liu K, Southall N, Titus SA, Inglese J, Eskay RL, Shinn P, Austin CP, Heilig MA, Zheng W. A multiplex calcium assay for identification of GPCR agonists and antagonists. Assay and Drug Development Technologies. 8: 367-79. PMID 20230302 DOI: 10.1089/adt.2009.0245  1
2010 Magnusson A, Göransson M, Heilig M. Early onset alcohol dependence with high density of family history is not "male limited". Alcohol (Fayetteville, N.Y.). 44: 131-9. PMID 20193873 DOI: 10.1016/j.alcohol.2010.01.001  1
2010 Spinelli S, Chefer S, Carson RE, Jagoda E, Lang L, Heilig M, Barr CS, Suomi SJ, Higley JD, Stein EA. Effects of early-life stress on serotonin(1A) receptors in juvenile Rhesus monkeys measured by positron emission tomography. Biological Psychiatry. 67: 1146-53. PMID 20172506 DOI: 10.1016/j.biopsych.2009.12.030  1
2010 Heilig M, Egli M, Crabbe JC, Becker HC. Acute withdrawal, protracted abstinence and negative affect in alcoholism: are they linked? Addiction Biology. 15: 169-84. PMID 20148778 DOI: 10.1111/j.1369-1600.2009.00194.x  1
2010 Stephens DN, Duka T, Crombag HS, Cunningham CL, Heilig M, Crabbe JC. Reward sensitivity: issues of measurement, and achieving consilience between human and animal phenotypes. Addiction Biology. 15: 145-68. PMID 20148777 DOI: 10.1111/j.1369-1600.2009.00193.x  1
2010 Leeman RF, Heilig M, Cunningham CL, Stephens DN, Duka T, O'Malley SS. Ethanol consumption: how should we measure it? Achieving consilience between human and animal phenotypes. Addiction Biology. 15: 109-24. PMID 20148775 DOI: 10.1111/j.1369-1600.2009.00192.x  1
2010 Cippitelli A, Damadzic R, Frankola K, Goldstein A, Thorsell A, Singley E, Eskay RL, Heilig M. Alcohol-induced neurodegeneration, suppression of transforming growth factor-beta, and cognitive impairment in rats: prevention by group II metabotropic glutamate receptor activation. Biological Psychiatry. 67: 823-30. PMID 20132926 DOI: 10.1016/j.biopsych.2009.12.018  1
2010 Schwandt ML, Lindell SG, Chen S, Higley JD, Suomi SJ, Heilig M, Barr CS. Alcohol response and consumption in adolescent rhesus macaques: life history and genetic influences. Alcohol (Fayetteville, N.Y.). 44: 67-80. PMID 20113875 DOI: 10.1016/j.alcohol.2009.09.034  1
2010 Thorsell A, Schank JR, Singley E, Hunt SP, Heilig M. Neurokinin-1 receptors (NK1R:s), alcohol consumption, and alcohol reward in mice. Psychopharmacology. 209: 103-11. PMID 20112009 DOI: 10.1007/s00213-010-1775-1  1
2010 Schwandt ML, Lindell SG, Sjöberg RL, Chisholm KL, Higley JD, Suomi SJ, Heilig M, Barr CS. Gene-environment interactions and response to social intrusion in male and female rhesus macaques. Biological Psychiatry. 67: 323-30. PMID 20015482 DOI: 10.1016/j.biopsych.2009.10.016  1
2010 Cippitelli A, Damadzic R, Hansson AC, Singley E, Sommer WH, Eskay R, Thorsell A, Heilig M. Neuropeptide Y (NPY) suppresses yohimbine-induced reinstatement of alcohol seeking. Psychopharmacology. 208: 417-26. PMID 20012021 DOI: 10.1007/s00213-009-1741-y  1
2010 Heilig M, Thorsell A, Sommer WH, Hansson AC, Ramchandani VA, George DT, Hommer D, Barr CS. Translating the neuroscience of alcoholism into clinical treatments: from blocking the buzz to curing the blues. Neuroscience and Biobehavioral Reviews. 35: 334-44. PMID 19941895 DOI: 10.1016/j.neubiorev.2009.11.018  1
2010 George DT, Herion DW, Jones CL, Phillips MJ, Hersh J, Hill D, Heilig M, Ramchandani VA, Geyer C, Spero DE, Singley ED, O'Malley SS, Bishai R, Rawlings RR, Kunos G. Rimonabant (SR141716) has no effect on alcohol self-administration or endocrine measures in nontreatment-seeking heavy alcohol drinkers. Psychopharmacology. 208: 37-44. PMID 19902183 DOI: 10.1007/s00213-009-1704-3  1
2010 Barr CS, Chen SA, Schwandt ML, Lindell SG, Sun H, Suomi SJ, Heilig M. Suppression of alcohol preference by naltrexone in the rhesus macaque: a critical role of genetic variation at the micro-opioid receptor gene locus. Biological Psychiatry. 67: 78-80. PMID 19748082 DOI: 10.1016/j.biopsych.2009.07.026  1
2009 Ciccocioppo R, Gehlert DR, Ryabinin A, Kaur S, Cippitelli A, Thorsell A, Lê AD, Hipskind PA, Hamdouchi C, Lu J, Hembre EJ, Cramer J, Song M, McKinzie D, Morin M, ... ... Heilig M, et al. Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond. Alcohol (Fayetteville, N.Y.). 43: 491-8. PMID 19913192 DOI: 10.1016/j.alcohol.2009.08.003  1
2009 Pickens CL, Adams-Deutsch T, Nair SG, Navarre BM, Heilig M, Shaham Y. Effect of pharmacological manipulations of neuropeptide Y and corticotropin-releasing factor neurotransmission on incubation of conditioned fear. Neuroscience. 164: 1398-406. PMID 19800945 DOI: 10.1016/j.neuroscience.2009.09.079  1
2009 Barr CS, Dvoskin RL, Gupte M, Sommer W, Sun H, Schwandt ML, Lindell SG, Kasckow JW, Suomi SJ, Goldman D, Higley JD, Heilig M. Functional CRH variation increases stress-induced alcohol consumption in primates. Proceedings of the National Academy of Sciences of the United States of America. 106: 14593-8. PMID 19706546 DOI: 10.1073/pnas.0902863106  1
2009 Jerlhag E, Egecioglu E, Landgren S, Salomé N, Heilig M, Moechars D, Datta R, Perrissoud D, Dickson SL, Engel JA. Requirement of central ghrelin signaling for alcohol reward. Proceedings of the National Academy of Sciences of the United States of America. 106: 11318-23. PMID 19564604 DOI: 10.1073/pnas.0812809106  1
2009 Cannella N, Economidou D, Kallupi M, Stopponi S, Heilig M, Massi M, Ciccocioppo R. Persistent increase of alcohol-seeking evoked by neuropeptide S: an effect mediated by the hypothalamic hypocretin system. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 2125-34. PMID 19322167 DOI: 10.1038/npp.2009.37  1
2009 Skinbjerg M, Ariano MA, Thorsell A, Heilig M, Halldin C, Innis RB, Sibley DR. Arrestin3 mediates D(2) dopamine receptor internalization. Synapse (New York, N.Y.). 63: 621-4. PMID 19309759 DOI: 10.1002/syn.20636  1
2009 Karlsson RM, Tanaka K, Saksida LM, Bussey TJ, Heilig M, Holmes A. Assessment of glutamate transporter GLAST (EAAT1)-deficient mice for phenotypes relevant to the negative and executive/cognitive symptoms of schizophrenia. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 1578-89. PMID 19078949 DOI: 10.1038/npp.2008.215  1
2009 Wahlberg K, Ghatan PH, Modell S, Nygren A, Ingvar M, Asberg M, Heilig M. Suppressed neuroendocrine stress response in depressed women on job-stress-related long-term sick leave: a stable marker potentially suggestive of preexisting vulnerability. Biological Psychiatry. 65: 742-7. PMID 19058782 DOI: 10.1016/j.biopsych.2008.10.035  1
2009 Neznanova O, Björk K, Rimondini R, Hansson AC, Hyytiä P, Heilig M, Sommer WH. Acute ethanol challenge inhibits glycogen synthase kinase-3beta in the rat prefrontal cortex. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 12: 275-80. PMID 19007447 DOI: 10.1017/S1461145708009620  1
2008 Heilig M, Gunne L. [New guidelines against unfair treatment of narcotic addicts necessary]. LäKartidningen. 105: 3093-4. PMID 19031975  1
2008 Barr CS, Dvoskin RL, Yuan Q, Lipsky RH, Gupte M, Hu X, Zhou Z, Schwandt ML, Lindell SG, McKee M, Becker ML, Kling MA, Gold PW, Higley D, Heilig M, et al. CRH haplotype as a factor influencing cerebrospinal fluid levels of corticotropin-releasing hormone, hypothalamic-pituitary-adrenal axis activity, temperament, and alcohol consumption in rhesus macaques. Archives of General Psychiatry. 65: 934-44. PMID 18678798 DOI: 10.1001/archpsyc.65.8.934  1
2008 Karlsson RM, Tanaka K, Heilig M, Holmes A. Loss of glial glutamate and aspartate transporter (excitatory amino acid transporter 1) causes locomotor hyperactivity and exaggerated responses to psychotomimetics: rescue by haloperidol and metabotropic glutamate 2/3 agonist. Biological Psychiatry. 64: 810-4. PMID 18550032 DOI: 10.1016/j.biopsych.2008.05.001  1
2008 Schwandt ML, Higley JD, Suomi SJ, Heilig M, Barr CS. Rapid tolerance and locomotor sensitization in ethanol-naïve adolescent rhesus macaques. Alcoholism, Clinical and Experimental Research. 32: 1217-28. PMID 18482160 DOI: 10.1111/j.1530-0277.2008.00676.x  1
2008 Hansson AC, Rimondini R, Neznanova O, Sommer WH, Heilig M. Neuroplasticity in brain reward circuitry following a history of ethanol dependence. The European Journal of Neuroscience. 27: 1912-22. PMID 18412612 DOI: 10.1111/j.1460-9568.2008.06159.x  1
2008 Barr CS, Schwandt ML, Lindell SG, Higley JD, Maestripieri D, Goldman D, Suomi SJ, Heilig M. Variation at the mu-opioid receptor gene (OPRM1) influences attachment behavior in infant primates. Proceedings of the National Academy of Sciences of the United States of America. 105: 5277-81. PMID 18378897 DOI: 10.1073/pnas.0710225105  1
2008 Björk K, Rimondini R, Hansson AC, Terasmaa A, Hyytiä P, Heilig M, Sommer WH. Modulation of voluntary ethanol consumption by beta-arrestin 2. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 2552-60. PMID 18367649 DOI: 10.1096/fj.07-102442  1
2008 Economidou D, Hansson AC, Weiss F, Terasmaa A, Sommer WH, Cippitelli A, Fedeli A, Martin-Fardon R, Massi M, Ciccocioppo R, Heilig M. Dysregulation of nociceptin/orphanin FQ activity in the amygdala is linked to excessive alcohol drinking in the rat. Biological Psychiatry. 64: 211-8. PMID 18367152 DOI: 10.1016/j.biopsych.2008.02.004  1
2008 Kakko J, Heilig M, Sarman I. Buprenorphine and methadone treatment of opiate dependence during pregnancy: comparison of fetal growth and neonatal outcomes in two consecutive case series. Drug and Alcohol Dependence. 96: 69-78. PMID 18355989 DOI: 10.1016/j.drugalcdep.2008.01.025  1
2008 George DT, Gilman J, Hersh J, Thorsell A, Herion D, Geyer C, Peng X, Kielbasa W, Rawlings R, Brandt JE, Gehlert DR, Tauscher JT, Hunt SP, Hommer D, Heilig M. Neurokinin 1 receptor antagonism as a possible therapy for alcoholism. Science (New York, N.Y.). 319: 1536-9. PMID 18276852 DOI: 10.1126/science.1153813  1
2008 Huang J, Young B, Pletcher MT, Heilig M, Wahlestedt C. Association between the nociceptin receptor gene (OPRL1) single nucleotide polymorphisms and alcohol dependence. Addiction Biology. 13: 88-94. PMID 18269382 DOI: 10.1111/j.1369-1600.2007.00089.x  1
2008 Karlsson RM, Choe JS, Cameron HA, Thorsell A, Crawley JN, Holmes A, Heilig M. The neuropeptide Y Y1 receptor subtype is necessary for the anxiolytic-like effects of neuropeptide Y, but not the antidepressant-like effects of fluoxetine, in mice. Psychopharmacology. 195: 547-57. PMID 17891380 DOI: 10.1007/s00213-007-0945-2  1
2008 Kakko J, von Wachenfeldt J, Svanborg KD, Lidström J, Barr CS, Heilig M. Mood and neuroendocrine response to a chemical stressor, metyrapone, in buprenorphine-maintained heroin dependence. Biological Psychiatry. 63: 172-7. PMID 17850768 DOI: 10.1016/j.biopsych.2007.05.001  1
2008 Rimondini R, Sommer WH, Dall'Olio R, Heilig M. Long-lasting tolerance to alcohol following a history of dependence. Addiction Biology. 13: 26-30. PMID 17850416 DOI: 10.1111/j.1369-1600.2007.00079.x  1
2008 Sommer WH, Rimondini R, Hansson AC, Hipskind PA, Gehlert DR, Barr CS, Heilig MA. Upregulation of voluntary alcohol intake, behavioral sensitivity to stress, and amygdala crhr1 expression following a history of dependence. Biological Psychiatry. 63: 139-45. PMID 17585886 DOI: 10.1016/j.biopsych.2007.01.010  1
2008 Heilig M. Triggering addiction Scientist. 22: 30-35.  1
2007 Spinelli S, Schwandt ML, Lindell SG, Newman TK, Heilig M, Suomi SJ, Higley JD, Goldman D, Barr CS. Association between the recombinant human serotonin transporter linked promoter region polymorphism and behavior in rhesus macaques during a separation paradigm. Development and Psychopathology. 19: 977-87. PMID 17931429 DOI: 10.1017/S095457940700048X  1
2007 Sommer WH, Rimondini R, Marquitz M, Lidström J, Siems WE, Bader M, Heilig M. Plasticity and impact of the central renin-angiotensin system during development of ethanol dependence. Journal of Molecular Medicine (Berlin, Germany). 85: 1089-97. PMID 17823780 DOI: 10.1007/s00109-007-0255-5  0.48
2007 Heilig M, Koob GF. A key role for corticotropin-releasing factor in alcohol dependence. Trends in Neurosciences. 30: 399-406. PMID 17629579 DOI: 10.1016/j.tins.2007.06.006  1
2007 Thorsell A, Johnson J, Heilig M. Effect of the adenosine A2a receptor antagonist 3,7-dimethyl-propargylxanthine on anxiety-like and depression-like behavior and alcohol consumption in Wistar Rats. Alcoholism, Clinical and Experimental Research. 31: 1302-7. PMID 17550371 DOI: 10.1111/j.1530-0277.2007.00425.x  0.68
2007 Hansson AC, Cippitelli A, Sommer WH, Ciccocioppo R, Heilig M. Region-specific down-regulation of Crhr1 gene expression in alcohol-preferring msP rats following ad lib access to alcohol. Addiction Biology. 12: 30-4. PMID 17407495 DOI: 10.1111/j.1369-1600.2007.00050.x  1
2007 Gehlert DR, Cippitelli A, Thorsell A, Lê AD, Hipskind PA, Hamdouchi C, Lu J, Hembre EJ, Cramer J, Song M, McKinzie D, Morin M, Ciccocioppo R, Heilig M. 3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine: a novel brain-penetrant, orally available corticotropin-releasing factor receptor 1 antagonist with efficacy in animal models of alcoholism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 2718-26. PMID 17344409 DOI: 10.1523/JNEUROSCI.4985-06.2007  1
2007 Barr CS, Schwandt M, Lindell SG, Chen SA, Goldman D, Suomi SJ, Higley JD, Heilig M. Association of a functional polymorphism in the mu-opioid receptor gene with alcohol response and consumption in male rhesus macaques. Archives of General Psychiatry. 64: 369-76. PMID 17339526 DOI: 10.1001/archpsyc.64.3.369  1
2007 Ciccocioppo R, Economidou D, Rimondini R, Sommer W, Massi M, Heilig M. Buprenorphine reduces alcohol drinking through activation of the nociceptin/orphanin FQ-NOP receptor system. Biological Psychiatry. 61: 4-12. PMID 16533497 DOI: 10.1016/j.biopsych.2006.01.006  1
2007 Hansson AC, Bermúdez-Silva FJ, Malinen H, Hyytiä P, Sanchez-Vera I, Rimondini R, Rodriguez de Fonseca F, Kunos G, Sommer WH, Heilig M. Genetic impairment of frontocortical endocannabinoid degradation and high alcohol preference. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 117-26. PMID 16482090 DOI: 10.1038/sj.npp.1301034  1
2006 Hansson AC, Cippitelli A, Sommer WH, Fedeli A, Björk K, Soverchia L, Terasmaa A, Massi M, Heilig M, Ciccocioppo R. Variation at the rat Crhr1 locus and sensitivity to relapse into alcohol seeking induced by environmental stress. Proceedings of the National Academy of Sciences of the United States of America. 103: 15236-41. PMID 17015825 DOI: 10.1073/pnas.0604419103  1
2006 Björk K, Saarikoski ST, Arlinde C, Kovanen L, Osei-Hyiaman D, Ubaldi M, Reimers M, Hyytiä P, Heilig M, Sommer WH. Glutathione-S-transferase expression in the brain: possible role in ethanol preference and longevity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 1826-35. PMID 16940154 DOI: 10.1096/fj.06-5896com  0.68
2006 Rydmark I, Wahlberg K, Ghatan PH, Modell S, Nygren A, Ingvar M, Asberg M, Heilig M. Neuroendocrine, cognitive and structural imaging characteristics of women on longterm sickleave with job stress-induced depression. Biological Psychiatry. 60: 867-73. PMID 16934773 DOI: 10.1016/j.biopsych.2006.04.029  1
2006 Thorsell A, Karlsson RM, Heilig M. NPY in alcoholism and psychiatric disorders. Exs. 183-92. PMID 16383007  1
2005 Spanagel R, Heilig M. Addiction and its brain science. Addiction (Abingdon, England). 100: 1813-22. PMID 16367982 DOI: 10.1111/j.1360-0443.2005.01260.x  1
2005 Reimers M, Heilig M, Sommer WH. Gene discovery in neuropharmacological and behavioral studies using Affymetrix microarray data. Methods (San Diego, Calif.). 37: 219-28. PMID 16308151 DOI: 10.1016/j.ymeth.2005.09.002  0.48
2005 Mottagui-Tabar S, Prince JA, Wahlestedt C, Zhu G, Goldman D, Heilig M. A novel single nucleotide polymorphism of the neuropeptide Y (NPY) gene associated with alcohol dependence. Alcoholism, Clinical and Experimental Research. 29: 702-7. PMID 15897713 DOI: 10.1097/01.ALC.0000164365.04961.B1  1
2005 Cippitelli A, Bilbao A, Hansson AC, del Arco I, Sommer W, Heilig M, Massi M, Bermúdez-Silva FJ, Navarro M, Ciccocioppo R, de Fonseca FR. Cannabinoid CB1 receptor antagonism reduces conditioned reinstatement of ethanol-seeking behavior in rats. The European Journal of Neuroscience. 21: 2243-51. PMID 15869521 DOI: 10.1111/j.1460-9568.2005.04056.x  1
2005 Karlsson RM, Holmes A, Heilig M, Crawley JN. Anxiolytic-like actions of centrally-administered neuropeptide Y, but not galanin, in C57BL/6J mice. Pharmacology, Biochemistry, and Behavior. 80: 427-36. PMID 15740785 DOI: 10.1016/j.pbb.2004.12.009  1
2005 Rimondini R, Thorsell A, Heilig M. Suppression of ethanol self-administration by the neuropeptide Y (NPY) Y2 receptor antagonist BIIE0246: evidence for sensitization in rats with a history of dependence. Neuroscience Letters. 375: 129-33. PMID 15670655 DOI: 10.1016/j.neulet.2004.10.084  0.68
2005 Bart G, Kreek MJ, Ott J, LaForge KS, Proudnikov D, Pollak L, Heilig M. Increased attributable risk related to a functional mu-opioid receptor gene polymorphism in association with alcohol dependence in central Sweden. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 30: 417-22. PMID 15525999 DOI: 10.1038/sj.npp.1300598  1
2004 Kalisch R, Salomé N, Platzer S, Wigger A, Czisch M, Sommer W, Singewald N, Heilig M, Berthele A, Holsboer F, Landgraf R, Auer DP. High trait anxiety and hyporeactivity to stress of the dorsomedial prefrontal cortex: a combined phMRI and Fos study in rats. Neuroimage. 23: 382-91. PMID 15325386 DOI: 10.1016/j.neuroimage.2004.06.012  1
2004 Mottagui-Tabar S, McCarthy S, Reinemund J, Andersson B, Wahlestedt C, Heilig M. Analysis of 5-hydroxytryptamine 2c receptor gene promoter variants as alcohol-dependence risk factors. Alcohol and Alcoholism (Oxford, Oxfordshire). 39: 380-5. PMID 15304380 DOI: 10.1093/alcalc/agh086  1
2004 Bart G, Heilig M, LaForge KS, Pollak L, Leal SM, Ott J, Kreek MJ. Substantial attributable risk related to a functional mu-opioid receptor gene polymorphism in association with heroin addiction in central Sweden. Molecular Psychiatry. 9: 547-9. PMID 15037869 DOI: 10.1038/sj.mp.4001504  1
2004 Heilig M, Zachrisson O, Thorsell A, Ehnvall A, Mottagui-Tabar S, Sjögren M, Asberg M, Ekman R, Wahlestedt C, Agren H. Decreased cerebrospinal fluid neuropeptide Y (NPY) in patients with treatment refractory unipolar major depression: preliminary evidence for association with preproNPY gene polymorphism. Journal of Psychiatric Research. 38: 113-21. PMID 14757324 DOI: 10.1016/S0022-3956(03)00101-8  1
2004 Ciccocioppo R, Economidou D, Fedeli A, Angeletti S, Weiss F, Heilig M, Massi M. Attenuation of ethanol self-administration and of conditioned reinstatement of alcohol-seeking behaviour by the antiopioid peptide nociceptin/orphanin FQ in alcohol-preferring rats. Psychopharmacology. 172: 170-8. PMID 14624331 DOI: 10.1007/s00213-003-1645-1  1
2004 Caberlotto L, Rimondini R, Hansson A, Eriksson S, Heilig M. Corticotropin-releasing hormone (CRH) mRNA expression in rat central amygdala in cannabinoid tolerance and withdrawal: evidence for an allostatic shift? Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 15-22. PMID 12968131 DOI: 10.1038/sj.npp.1300296  0.32
2003 Rimondini R, Sommer W, Heilig M. A temporal threshold for induction of persistent alcohol preference: behavioral evidence in a rat model of intermittent intoxication. Journal of Studies On Alcohol. 64: 445-9. PMID 12921185  0.32
2003 Kela J, Salmi P, Rimondini-Giorgini R, Heilig M, Wahlestedt C. Behavioural analysis of melanin-concentrating hormone in rats: evidence for orexigenic and anxiolytic properties. Regulatory Peptides. 114: 109-14. PMID 12832098 DOI: 10.1016/S0167-0115(03)00114-9  1
2003 Rimondini R, Agren G, Börjesson S, Sommer W, Heilig M. Persistent behavioral and autonomic supersensitivity to stress following prenatal stress exposure in rats. Behavioural Brain Research. 140: 75-80. PMID 12644280 DOI: 10.1016/S0166-4328(02)00273-5  1
2003 Adolfsson R, Bejerot S, Engel J, Forssberg H, Heilig M, Humble M, Ingvar M, Levander S, Oreland L, Pedersen N, Asberg M, Ohman A. [Researchers and psychiatrists defending Gillberg's research on ADDH: Karfve's campaign is a form of personal persecution and scientific basis is missing]. LäKartidningen. 100: 636-7. PMID 12640980  1
2003 Pandey SC, Carr LG, Heilig M, Ilveskoski E, Thiele TE. Neuropeptide y and alcoholism: genetic, molecular, and pharmacological evidence. Alcoholism, Clinical and Experimental Research. 27: 149-54. PMID 12605064 DOI: 10.1097/01.ALC.0000052706.21367.0E  1
2003 Zhu G, Pollak L, Mottagui-Tabar S, Wahlestedt C, Taubman J, Virkkunen M, Goldman D, Heilig M. NPY Leu7Pro and alcohol dependence in Finnish and Swedish populations. Alcoholism, Clinical and Experimental Research. 27: 19-24. PMID 12544000 DOI: 10.1097/01.ALC.0000050642.62233.44  1
2002 Heilig M, Forslund K, Asberg M, Rydberg U. The dual-diagnosis concept used by Swedish social workers: limited validity upon examination using a structured diagnostic approach. European Psychiatry : the Journal of the Association of European Psychiatrists. 17: 363-5. PMID 12457747 DOI: 10.1016/S0924-9338(02)00690-9  1
2002 Thorsell A, Rimondini R, Heilig M. Blockade of central neuropeptide Y (NPY) Y2 receptors reduces ethanol self-administration in rats. Neuroscience Letters. 332: 1-4. PMID 12377370  0.68
2002 Thorsell A, Heilig M. Diverse functions of neuropeptide Y revealed using genetically modified animals. Neuropeptides. 36: 182-93. PMID 12359508  0.68
2002 Heilig M, Oreland L, Ekman R, Akerstedt T, Nygren A. [The brain behind stress and fatigue depression]. LäKartidningen. 99: 2515-8. PMID 12092052  0.72
2002 Heilig M, Thorsell A. Brain neuropeptide Y (NPY) in stress and alcohol dependence. Reviews in the Neurosciences. 13: 85-94. PMID 12013027  0.68
2002 Rimondini R, Sommer W, Heilig M. Effects of tiagabine and diazepam on operant ethanol self-administration in the rat. Journal of Studies On Alcohol. 63: 100-6. PMID 11925051  0.32
2002 Möller C, Sommer W, Thorsell A, Rimondini R, Heilig M. Anxiogenic-like action of centrally administered glucagon-like peptide-1 in a punished drinking test. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 26: 119-22. PMID 11853101  0.68
2002 Thorsell A, Caberlotto L, Rimondini R, Heilig M. Leptin suppression of hypothalamic NPY expression and feeding, but not amygdala NPY expression and experimental anxiety. Pharmacology, Biochemistry, and Behavior. 71: 425-30. PMID 11830177  0.68
2002 Rimondini R, Arlinde C, Sommer W, Heilig M. Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 27-35. PMID 11772933 DOI: 10.1096/fj.01-0593com  0.32
2001 Wicks S, Hammar J, Heilig M, Wisén O. Factors Affecting the Short-Term Prognosis of Alcohol Dependent Patients Undergoing Inpatient Detoxification. Substance Abuse : Official Publication of the Association For Medical Education and Research in Substance Abuse. 22: 235-245. PMID 12466683 DOI: 10.1080/08897070109511465  1
2001 Thorsell A, Gruber SH, Mathé AA, Heilig M. Neuropeptide Y (NPY) mRNA in rat brain tissue: effects of decapitation and high-energy microwave irradiation on post mortem stability. Neuropeptides. 35: 168-73. PMID 11884207 DOI: 10.1054/npep.2001.0860  0.68
2001 Caberlotto L, Thorsell A, Rimondini R, Sommer W, Hyytiä P, Heilig M. Differential expression of NPY and its receptors in alcohol-preferring AA and alcohol-avoiding ANA rats. Alcoholism, Clinical and Experimental Research. 25: 1564-9. PMID 11707630  0.68
2001 Sommer W, Arlinde C, Caberlotto L, Thorsell A, Hyytia P, Heilig M. Differential expression of diacylglycerol kinase iota and L18A mRNAs in the brains of alcohol-preferring AA and alcohol-avoiding ANA rats. Molecular Psychiatry. 6: 103-8; 5. PMID 11244494  0.68
2001 Sommer W, Möller C, Wiklund L, Thorsell A, Rimondini R, Nissbrandt H, Heilig M. Local 5,7-dihydroxytryptamine lesions of rat amygdala: release of punished drinking, unaffected plus-maze behavior and ethanol consumption. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 24: 430-40. PMID 11182538 DOI: 10.1016/S0893-133X(00)00210-4  0.68
2000 Thorsell A, Michalkiewicz M, Dumont Y, Quirion R, Caberlotto L, Rimondini R, Mathé AA, Heilig M. Behavioral insensitivity to restraint stress, absent fear suppression of behavior and impaired spatial learning in transgenic rats with hippocampal neuropeptide Y overexpression. Proceedings of the National Academy of Sciences of the United States of America. 97: 12852-7. PMID 11058155 DOI: 10.1073/pnas.220232997  0.68
2000 Sommer W, Hebb MO, Heilig M. Pharmacokinetic properties of oligonucleotides in brain. Methods in Enzymology. 314: 261-75. PMID 10565019 DOI: 10.1016/S0076-6879(99)14109-0  1
1999 Thorsell A, Carlsson K, Ekman R, Heilig M. Behavioral and endocrine adaptation, and up-regulation of NPY expression in rat amygdala following repeated restraint stress. Neuroreport. 10: 3003-7. PMID 10549813  0.72
1999 Möller C, Sommer W, Thorsell A, Heilig M. Anxiogenic-like action of galanin after intra-amygdala administration in the rat. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 21: 507-12. PMID 10481834 DOI: 10.1016/S0893-133X(98)00102-X  0.68
1999 Thorsell A, Fox E, Heilig M. Lipid mediated gene delivery in the adult rat brain: quantitative analysis of expression. Neurochemistry International. 35: 65-71. PMID 10403431 DOI: 10.1016/S0197-0186(99)00034-0  1
1998 Thorsell A, Svensson P, Wiklund L, Sommer W, Ekman R, Heilig M. Suppressed neuropeptide Y (NPY) mRNA in rat amygdala following restraint stress. Regulatory Peptides. 75: 247-54. PMID 9802416  0.72
1998 Sommer W, Cui X, Erdmann B, Wiklund L, Bricca G, Heilig M, Fuxe K. The spread and uptake pattern of intracerebrally administered oligonucleotides in nerve and glial cell populations of the rat brain. Antisense & Nucleic Acid Drug Development. 8: 75-85. PMID 9593045  1
1997 Svenningsson P, Georgieva J, Kontny E, Heilig M, Fredholm BB. Involvement of a c-fos-dependent mechanism in caffeine-induced expression of the preprotachykinin A and neurotensin/neuromedin N genes in rat striatum. The European Journal of Neuroscience. 9: 2135-41. PMID 9421173 DOI: 10.1111/j.1460-9568.1997.tb01380.x  1
1997 Möller C, Wiklund L, Sommer W, Thorsell A, Heilig M. Decreased experimental anxiety and voluntary ethanol consumption in rats following central but not basolateral amygdala lesions. Brain Research. 760: 94-101. PMID 9237523  0.68
1997 Möller C, Wiklund L, Thorsell A, Hyytiä P, Heilig M. Decreased measures of experimental anxiety in rats bred for high alcohol preference. Alcoholism, Clinical and Experimental Research. 21: 656-60. PMID 9194920  0.68
1996 Ekman R, Juhasz P, Heilig M, Agren H, Costello CE. Novel neuropeptide Y processing in human cerebrospinal fluid from depressed patients. Peptides. 17: 1107-11. PMID 8959743 DOI: 10.1016/S0196-9781(96)00168-4  1
1996 Blennow K, Davidsson P, Gottfries CG, Ekman R, Heilig M. Synaptic degeneration in thalamus in schizophrenia. Lancet. 348: 692-3. PMID 8782788 DOI: 10.1016/S0140-6736(05)65124-0  0.72
1996 Nilsson C, Karlsson G, Blennow K, Heilig M, Ekman R. Differences in the neuropeptide Y-like immunoreactivity of the plasma and platelets of human volunteers and depressed patients. Peptides. 17: 359-62. PMID 8735959  0.72
1996 Thorsell A, Blomqvist AG, Heilig M. Cationic lipid-mediated delivery and expression of prepro-neuropeptide Y cDNA after intraventricular administration in rat: feasibility and limitations. Regulatory Peptides. 61: 205-11. PMID 8701037  0.68
1995 Heilig M, Sjögren M, Blennow K, Ekman R, Wallin A. Cerebrospinal fluid neuropeptides in Alzheimer's disease and vascular dementia. Biological Psychiatry. 38: 210-6. PMID 8547442 DOI: 10.1016/0006-3223(94)00239-Y  0.72
1995 Heilig M, Ekman R. Chronic parenteral antidepressant treatment in rats: unaltered levels and processing of neuropeptide Y (NPY) and corticotropin-releasing hormone (CRH). Neurochemistry International. 26: 351-5. PMID 7633328  0.72
1994 Heilig M, Koob GF, Ekman R, Britton KT. Corticotropin-releasing factor and neuropeptide Y: role in emotional integration. Trends in Neurosciences. 17: 80-5. PMID 7512773  1
1993 Pich EM, Koob GF, Heilig M, Menzaghi F, Vale W, Weiss F. Corticotropin-releasing factor release from the mediobasal hypothalamus of the rat as measured by microdialysis. Neuroscience. 55: 695-707. PMID 8413932  1
1993 Wahlestedt C, Pich EM, Koob GF, Yee F, Heilig M. Modulation of anxiety and neuropeptide Y-Y1 receptors by antisense oligodeoxynucleotides. Science (New York, N.Y.). 259: 528-31. PMID 8380941  1
1993 Heilig M, Engel JA, Söderpalm B. C-fos antisense in the nucleus accumbens blocks the locomotor stimulant action of cocaine. European Journal of Pharmacology. 236: 339-40. PMID 8319761 DOI: 10.1016/0014-2999(93)90610-T  1
1993 Heilig M, McLeod S, Brot M, Heinrichs SC, Menzaghi F, Koob GF, Britton KT. Anxiolytic-like action of neuropeptide Y: mediation by Y1 receptors in amygdala, and dissociation from food intake effects. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 8: 357-63. PMID 8099792 DOI: 10.1038/npp.1993.35  1
1993 Bing O, Möller C, Engel JA, Söderpalm B, Heilig M. Anxiolytic-like action of centrally administered galanin. Neuroscience Letters. 164: 17-20. PMID 7512244 DOI: 10.1016/0304-3940(93)90846-D  1
1992 Heilig M, McLeod S, Koob GK, Britton KT. Anxiolytic-like effect of neuropeptide Y (NPY), but not other peptides in an operant conflict test. Regulatory Peptides. 41: 61-9. PMID 1360689  0.72
1991 Heilig M, Edvinsson L, Wahlestedt C. Effects of intracerebroventricular D-myo-inositol-1,2,6-trisphosphate (PP56), a proposed neuropeptide Y (NPY) antagonist, on locomotor activity, food intake, central effects of NPY and NPY-receptor binding. European Journal of Pharmacology. 209: 27-32. PMID 1667639 DOI: 10.1016/0014-2999(91)90006-C  1
1990 Wahlestedt C, Blendy JA, Kellar KJ, Heilig M, Widerlöv E, Ekman R. Electroconvulsive shocks increase the concentration of neocortical and hippocampal neuropeptide Y (NPY)-like immunoreactivity in the rat. Brain Research. 507: 65-8. PMID 2302581 DOI: 10.1016/0006-8993(90)90523-E  1
1989 Heilig M, Söderpalm B, Engel JA, Widerlöv E. Centrally administered neuropeptide Y (NPY) produces anxiolytic-like effects in animal anxiety models. Psychopharmacology. 98: 524-9. PMID 2570434 DOI: 10.1007/BF00441953  1
1989 Wahlestedt C, Ekman R, Heilig M, Widerlöv E. Effects of psychoactive drugs on delta sleep-inducing peptide concentrations in rat brain. European Journal of Pharmacology. 159: 285-9. PMID 2522052  0.72
1988 Heilig M, Wahlestedt C, Ekman R, Widerlöv E. Antidepressant drugs increase the concentration of neuropeptide Y (NPY)-like immunoreactivity in the rat brain. European Journal of Pharmacology. 147: 465-7. PMID 2967771  0.72
1987 Wahlestedt C, Skagerberg G, Ekman R, Heilig M, Sundler F, HÃ¥kanson R. Neuropeptide Y (NPY) in the area of the hypothalamic paraventricular nucleus activates the pituitary-adrenocortical axis in the rat. Brain Research. 417: 33-8. PMID 3040184 DOI: 10.1016/0006-8993(87)90176-4  1
1987 HÃ¥kanson R, Beding B, Ekman R, Heilig M, Wahlestedt C, Sundler F. Multiple tachykinin pools in sensory nerve fibres in the rabbit iris. Neuroscience. 21: 943-50. PMID 2442656  0.72
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