George R. Siggins - Publications

Affiliations: 
Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
Electrophysiology, neuropharmacology, drug and alcohol abuse
Website:
http://www.scripps.edu/research/faculty.php?rec_id=1778

163 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Park MK, Kieffer B, Roberts AJ, Siggins GR, Moore SD. Interaction of CRF and Kappa Opioid Systems on GABAergic Neurotransmission in the Mouse Central Amygdala. The Journal of Pharmacology and Experimental Therapeutics. PMID 26350161 DOI: 10.1124/jpet.115.225870  0.32
2015 Bajo M, Varodayan FP, Madamba SG, Robert AJ, Casal LM, Oleata CS, Siggins GR, Roberto M. IL-1 interacts with ethanol effects on GABAergic transmission in the mouse central amygdala. Frontiers in Pharmacology. 6: 49. PMID 25852553 DOI: 10.3389/fphar.2015.00049  1
2014 Bajo M, Madamba SG, Roberto M, Siggins GR. Acute morphine alters GABAergic transmission in the central amygdala during naloxone-precipitated morphine withdrawal: role of cyclic AMP. Frontiers in Integrative Neuroscience. 8: 45. PMID 24926240 DOI: 10.3389/fnint.2014.00045  1
2014 Bajo M, Madamba SG, Roberto M, Blednov YA, Sagi VN, Roberts E, Rice KC, Harris RA, Siggins GR. Innate immune factors modulate ethanol interaction with GABAergic transmission in mouse central amygdala. Brain, Behavior, and Immunity. 40: 191-202. PMID 24675033 DOI: 10.1016/j.bbi.2014.03.007  1
2013 Kang-Park M, Kieffer BL, Roberts AJ, Siggins GR, Moore SD. κ-Opioid receptors in the central amygdala regulate ethanol actions at presynaptic GABAergic sites. The Journal of Pharmacology and Experimental Therapeutics. 346: 130-7. PMID 23587526 DOI: 10.1124/jpet.112.202903  1
2012 Roberto M, Gilpin NW, Siggins GR. The central amygdala and alcohol: role of γ-aminobutyric acid, glutamate, and neuropeptides. Cold Spring Harbor Perspectives in Medicine. 2: a012195. PMID 23085848 DOI: 10.1101/cshperspect.a012195  1
2012 Bajo M, Madamba SG, Lu X, Sharkey LM, Bartfai T, Siggins GR. Receptor subtype-dependent galanin actions on gamma-aminobutyric acidergic neurotransmission and ethanol responses in the central amygdala. Addiction Biology. 17: 694-705. PMID 21955024 DOI: 10.1111/j.1369-1600.2011.00360.x  1
2011 Cruz MT, Bajo M, Maragnoli ME, Tabakoff B, Siggins GR, Roberto M. Type 7 Adenylyl Cyclase is Involved in the Ethanol and CRF Sensitivity of GABAergic Synapses in Mouse Central Amygdala. Frontiers in Neuroscience. 4: 207. PMID 21258618 DOI: 10.3389/fnins.2010.00207  1
2011 Bajo M, Roberto M, Madamba SG, Siggins GR. Neuroadaptation of GABAergic transmission in the central amygdala during chronic morphine treatment. Addiction Biology. 16: 551-64. PMID 21182569 DOI: 10.1111/j.1369-1600.2010.00269.x  1
2010 Roberto M, Cruz M, Bajo M, Siggins GR, Parsons LH, Schweitzer P. The endocannabinoid system tonically regulates inhibitory transmission and depresses the effect of ethanol in central amygdala. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 1962-72. PMID 20463657 DOI: 10.1038/npp.2010.70  1
2010 Roberto M, Cruz MT, Gilpin NW, Sabino V, Schweitzer P, Bajo M, Cottone P, Madamba SG, Stouffer DG, Zorrilla EP, Koob GF, Siggins GR, Parsons LH. Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence. Biological Psychiatry. 67: 831-9. PMID 20060104 DOI: 10.1016/j.biopsych.2009.11.007  1
2009 Silberman Y, Bajo M, Chappell AM, Christian DT, Cruz M, Diaz MR, Kash T, Lack AK, Messing RO, Siggins GR, Winder D, Roberto M, McCool BA, Weiner JL. Neurobiological mechanisms contributing to alcohol-stress-anxiety interactions. Alcohol (Fayetteville, N.Y.). 43: 509-19. PMID 19913194 DOI: 10.1016/j.alcohol.2009.01.002  1
2009 Nie Z, Zorrilla EP, Madamba SG, Rice KC, Roberto M, Siggins GR. Presynaptic CRF1 receptors mediate the ethanol enhancement of GABAergic transmission in the mouse central amygdala. Thescientificworldjournal. 9: 68-85. PMID 19151899 DOI: 10.1100/tsw.2009.1  1
2009 Kang-Park MH, Kieffer BL, Roberts AJ, Roberto M, Madamba SG, Siggins GR, Moore SD. Mu-opioid receptors selectively regulate basal inhibitory transmission in the central amygdala: lack of ethanol interactions. The Journal of Pharmacology and Experimental Therapeutics. 328: 284-93. PMID 18854491 DOI: 10.1124/jpet.108.140749  1
2008 Bajo M, Cruz MT, Siggins GR, Messing R, Roberto M. Protein kinase C epsilon mediation of CRF- and ethanol-induced GABA release in central amygdala. Proceedings of the National Academy of Sciences of the United States of America. 105: 8410-5. PMID 18541912 DOI: 10.1073/pnas.0802302105  1
2008 Roberto M, Gilpin NW, O'Dell LE, Cruz MT, Morse AC, Siggins GR, Koob GF. Cellular and behavioral interactions of gabapentin with alcohol dependence. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 5762-71. PMID 18509038 DOI: 10.1523/JNEUROSCI.0575-08.2008  1
2008 Sharkey LM, Madamba SG, Siggins GR, Bartfai T. Galanin alters GABAergic neurotransmission in the dorsal raphe nucleus. Neurochemical Research. 33: 285-91. PMID 17973188 DOI: 10.1007/s11064-007-9524-5  1
2007 Kang-Park MH, Kieffer BL, Roberts AJ, Siggins GR, Moore SD. Presynaptic delta opioid receptors regulate ethanol actions in central amygdala. The Journal of Pharmacology and Experimental Therapeutics. 320: 917-25. PMID 17114568 DOI: 10.1124/jpet.106.112722  1
2006 Roberto M, Siggins GR. Nociceptin/orphanin FQ presynaptically decreases GABAergic transmission and blocks the ethanol-induced increase of GABA release in central amygdala. Proceedings of the National Academy of Sciences of the United States of America. 103: 9715-20. PMID 16788074 DOI: 10.1073/pnas.0601899103  1
2006 Breese GR, Criswell HE, Carta M, Dodson PD, Hanchar HJ, Khisti RT, Mameli M, Ming Z, Morrow AL, Olsen RW, Otis TS, Parsons LH, Penland SN, Roberto M, Siggins GR, et al. Basis of the gabamimetic profile of ethanol. Alcoholism, Clinical and Experimental Research. 30: 731-44. PMID 16573592 DOI: 10.1111/j.0145-6008.2006.00086.x  1
2006 Bajo M, Crawford EF, Roberto M, Madamba SG, Siggins GR. Chronic morphine treatment alters expression of N-methyl-D-aspartate receptor subunits in the extended amygdala. Journal of Neuroscience Research. 83: 532-7. PMID 16453311 DOI: 10.1002/jnr.20756  1
2006 Roberto M, Treistman SN, Pietrzykowski AZ, Weiner J, Galindo R, Mameli M, Valenzuela F, Zhu PJ, Lovinger D, Zhang TA, Hendricson AH, Morrisett R, Siggins GR. Actions of acute and chronic ethanol on presynaptic terminals. Alcoholism, Clinical and Experimental Research. 30: 222-32. PMID 16441271 DOI: 10.1111/j.1530-0277.2006.00030.x  1
2006 Roberto M, Bajo M, Crawford E, Madamba SG, Siggins GR. Chronic ethanol exposure and protracted abstinence alter NMDA receptors in central amygdala. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 988-96. PMID 16052244 DOI: 10.1038/sj.npp.1300840  1
2005 Tallent MK, Fabre V, Qiu C, Calbet M, Lamp T, Baratta MV, Suzuki C, Levy CL, Siggins GR, Henriksen SJ, Criado JR, Roberts A, de Lecea L. Cortistatin overexpression in transgenic mice produces deficits in synaptic plasticity and learning. Molecular and Cellular Neurosciences. 30: 465-75. PMID 16182561 DOI: 10.1016/j.mcn.2005.08.010  1
2005 Siggins GR, Roberto M, Nie Z. The tipsy terminal: presynaptic effects of ethanol. Pharmacology & Therapeutics. 107: 80-98. PMID 15963352 DOI: 10.1016/j.pharmthera.2005.01.006  1
2004 Roberto M, Madamba SG, Stouffer DG, Parsons LH, Siggins GR. Increased GABA release in the central amygdala of ethanol-dependent rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 10159-66. PMID 15537886 DOI: 10.1523/JNEUROSCI.3004-04.2004  1
2004 Martin G, Guadaño-Ferraz A, Morte B, Ahmed S, Koob GF, De Lecea L, Siggins GR. Chronic morphine treatment alters N-methyl-D-aspartate receptors in freshly isolated neurons from nucleus accumbens. The Journal of Pharmacology and Experimental Therapeutics. 311: 265-73. PMID 15263066 DOI: 10.1124/jpet.104.067504  1
2004 Schweitzer P, Roberto M, Madamba SG, Siggins GR. gamma-hydroxybutyrate increases a potassium current and decreases the H-current in hippocampal neurons via GABAB receptors. The Journal of Pharmacology and Experimental Therapeutics. 311: 172-9. PMID 15152029 DOI: 10.1124/jpet.104.069534  1
2004 Vlkolinský R, Siggins GR, Campbell IL, Krucker T. Acute exposure to CXC chemokine ligand 10, but not its chronic astroglial production, alters synaptic plasticity in mouse hippocampal slices. Journal of Neuroimmunology. 150: 37-47. PMID 15081247 DOI: 10.1016/j.jneuroim.2004.01.011  1
2004 Nie Z, Schweitzer P, Roberts AJ, Madamba SG, Moore SD, Siggins GR. Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors. Science (New York, N.Y.). 303: 1512-4. PMID 15001778 DOI: 10.1126/science.1092550  1
2004 Roberto M, Schweitzer P, Madamba SG, Stouffer DG, Parsons LH, Siggins GR. Acute and chronic ethanol alter glutamatergic transmission in rat central amygdala: an in vitro and in vivo analysis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 1594-603. PMID 14973247 DOI: 10.1523/JNEUROSCI.5077-03.2004  1
2003 Siggins GR, Martin G, Roberto M, Nie Z, Madamba S, De Lecea L. Glutamatergic transmission in opiate and alcohol dependence. Annals of the New York Academy of Sciences. 1003: 196-211. PMID 14684447 DOI: 10.1196/annals.1300.012  1
2003 Schweitzer P, Madamba SG, Siggins GR. The sleep-modulating peptide cortistatin augments the h-current in hippocampal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 10884-91. PMID 14645483  1
2003 Roberto M, Madamba SG, Moore SD, Tallent MK, Siggins GR. Ethanol increases GABAergic transmission at both pre- and postsynaptic sites in rat central amygdala neurons. Proceedings of the National Academy of Sciences of the United States of America. 100: 2053-8. PMID 12566570 DOI: 10.1073/pnas.0437926100  1
2002 Martin G, Siggins GR. Electrophysiological evidence for expression of glycine receptors in freshly isolated neurons from nucleus accumbens. The Journal of Pharmacology and Experimental Therapeutics. 302: 1135-45. PMID 12183673 DOI: 10.1124/jpet.102.033399  1
2002 Krucker T, Siggins GR, McNamara RK, Lindsley KA, Dao A, Allison DW, De Lecea L, Lovenberg TW, Sutcliffe JG, Gerendasy DD. Targeted disruption of RC3 reveals a calmodulin-based mechanism for regulating metaplasticity in the hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 5525-35. PMID 12097504  1
2002 Koob GF, Mason BJ, De Witte P, Littleton J, Siggins GR. Potential neuroprotective effects of acamprosate. Alcoholism, Clinical and Experimental Research. 26: 586-92. PMID 11981137  1
2002 Martin G, Fabre V, Siggins GR, de Lecea L. Interaction of the hypocretins with neurotransmitters in the nucleus accumbens. Regulatory Peptides. 104: 111-7. PMID 11830285 DOI: 10.1016/S0167-0115(01)00354-8  1
2001 Tallent MK, Madamba SG, Siggins GR. Nociceptin reduces epileptiform events in CA3 hippocampus via presynaptic and postsynaptic mechanisms. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 6940-8. PMID 11517281  1
2000 Steffensen SC, Nie Z, Criado JR, Siggins GR. Ethanol inhibition of N-methyl-D-aspartate responses involves presynaptic gamma-aminobutyric acid(B) receptors. The Journal of Pharmacology and Experimental Therapeutics. 294: 637-47. PMID 10900243  1
2000 Sanna PP, Berton F, Cammalleri M, Tallent MK, Siggins GR, Bloom FE, Francesconi W. A role for Src kinase in spontaneous epileptiform activity in the CA3 region of the hippocampus. Proceedings of the National Academy of Sciences of the United States of America. 97: 8653-7. PMID 10890901 DOI: 10.1073/pnas.140219097  1
2000 Krucker T, Siggins GR, Halpain S. Dynamic actin filaments are required for stable long-term potentiation (LTP) in area CA1 of the hippocampus. Proceedings of the National Academy of Sciences of the United States of America. 97: 6856-61. PMID 10823894 DOI: 10.1073/pnas.100139797  1
2000 Nie Z, Madamba SG, Siggins GR. Ethanol enhances gamma-aminobutyric acid responses in a subpopulation of nucleus accumbens neurons: role of metabotropic glutamate receptors. The Journal of Pharmacology and Experimental Therapeutics. 293: 654-61. PMID 10773041  1
1999 Schweitzer P, Siggins GR, Madamba SG. Cannabinoid modulation of neuronal activity in adult rat hippocampus. Advances in Experimental Medicine and Biology. 469: 547-52. PMID 10667381  1
1999 Przewlocki R, Parsons KL, Sweeney DD, Trotter C, Netzeband JG, Siggins GR, Gruol DL. Opioid enhancement of calcium oscillations and burst events involving NMDA receptors and L-type calcium channels in cultured hippocampal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 9705-15. PMID 10559380  1
1999 Martin G, Ahmed SH, Blank T, Spiess J, Koob GF, Siggins GR. Chronic morphine treatment alters NMDA receptor-mediated synaptic transmission in the nucleus accumbens. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 9081-9. PMID 10516325  1
1999 Madamba SG, Schweitzer P, Siggins GR. Nociceptin augments K(+) currents in hippocampal CA1 neurons by both ORL-1 and opiate receptor mechanisms. Journal of Neurophysiology. 82: 1776-85. PMID 10515967  1
1999 Madamba SG, Schweitzer P, Siggins GR. Dynorphin selectively augments the M-current in hippocampal CA1 neurons by an opiate receptor mechanism. Journal of Neurophysiology. 82: 1768-75. PMID 10515966  1
1999 Campbell IL, Krucker T, Steffensen S, Akwa Y, Powell HC, Lane T, Carr DJ, Gold LH, Henriksen SJ, Siggins GR. Structural and functional neuropathology in transgenic mice with CNS expression of IFN-alpha. Brain Research. 835: 46-61. PMID 10448195 DOI: 10.1016/S0006-8993(99)01328-1  1
1999 Tallent MK, Siggins GR. Somatostatin acts in CA1 and CA3 to reduce hippocampal epileptiform activity. Journal of Neurophysiology. 81: 1626-35. PMID 10200199  1
1999 Martin G, Przewlocki R, Siggins GR. Chronic morphine treatment selectively augments metabotropic glutamate receptor-induced inhibition of N-methyl-D-aspartate receptor-mediated neurotransmission in nucleus accumbens. The Journal of Pharmacology and Experimental Therapeutics. 288: 30-5. PMID 9862749  1
1998 Berton F, Francesconi WG, Madamba SG, Zieglgänsberger W, Siggins GR. Acamprosate enhances N-methyl-D-apartate receptor-mediated neurotransmission but inhibits presynaptic GABA(B) receptors in nucleus accumbens neurons. Alcoholism, Clinical and Experimental Research. 22: 183-91. PMID 9514305  1
1998 Schweitzer P, Madamba SG, Siggins GR. Somatostatin increases a voltage-insensitive K+ conductance in rat CA1 hippocampal neurons. Journal of Neurophysiology. 79: 1230-8. PMID 9497404  1
1998 Krucker T, Toggas SM, Mucke L, Siggins GR. Transgenic mice with cerebral expression of human immunodeficiency virus type-1 coat protein gp120 show divergent changes in short- and long-term potentiation in CA1 hippocampus. Neuroscience. 83: 691-700. PMID 9483553 DOI: 10.1016/S0306-4522(97)00413-2  1
1997 Martin G, Nie Z, Siggins GR. Metabotropic glutamate receptors regulate N-methyl-D-aspartate-mediated synaptic transmission in nucleus accumbens. Journal of Neurophysiology. 78: 3028-38. PMID 9405522  1
1997 Tallent MK, Siggins GR. Somatostatin depresses excitatory but not inhibitory neurotransmission in rat CA1 hippocampus. Journal of Neurophysiology. 78: 3008-18. PMID 9405520  1
1997 Francesconi W, Berton F, Demuro A, Madamba SG, Siggins GR. Naloxone blocks long-term depression of excitatory transmission in rat CA1 hippocampus in vitro. Archives Italiennes De Biologie. 135: 37-48. PMID 9139581  1
1997 Campbell IL, Stalder AK, Chiang CS, Bellinger R, Heyser CJ, Steffensen S, Masliah E, Powell HC, Gold LH, Henriksen SJ, Siggins GR. Transgenic models to assess the pathogenic actions of cytokines in the central nervous system. Molecular Psychiatry. 2: 125-9. PMID 9106234  1
1997 Martin G, Nie Z, Siggins GR. mu-Opioid receptors modulate NMDA receptor-mediated responses in nucleus accumbens neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 11-22. PMID 8987732  1
1996 Madamba SG, Schweitzer P, Zieglgänsberger W, Siggins GR. Acamprosate (calcium acetylhomotaurinate) enhances the N-methyl-D-aspartate component of excitatory neurotransmission in rat hippocampal CA1 neurons in vitro. Alcoholism, Clinical and Experimental Research. 20: 651-8. PMID 8800380  1
1996 Gold LH, Heyser CJ, Roberts AJ, Henriksen SJ, Steffensen SC, Siggins GR, Bellinger FP, Chiang CS, Powell HC, Masliah E, Campbell IL. Behavioral and neurophysiological effects of CNS expression of cytokines in transgenic mice. Advances in Experimental Medicine and Biology. 402: 199-205. PMID 8787661  1
1996 Wan FJ, Berton F, Madamba SG, Francesconi W, Siggins GR. Low ethanol concentrations enhance GABAergic inhibitory postsynaptic potentials in hippocampal pyramidal neurons only after block of GABAB receptors. Proceedings of the National Academy of Sciences of the United States of America. 93: 5049-54. PMID 8643527  1
1996 de Lecea L, Criado JR, Prospero-Garcia O, Gautvik KM, Schweitzer P, Danielson PE, Dunlop CL, Siggins GR, Henriksen SJ, Sutcliffe JG. A cortical neuropeptide with neuronal depressant and sleep-modulating properties. Nature. 381: 242-5. PMID 8622767 DOI: 10.1038/381242a0  1
1996 Lammers CH, Schweitzer P, Facchinetti P, Arrang JM, Madamba SG, Siggins GR, Piomelli D. Arachidonate 5-lipoxygenase and its activating protein: prominent hippocampal expression and role in somatostatin signaling. Journal of Neurochemistry. 66: 147-52. PMID 8522947  1
1995 Bellinger FP, Madamba SG, Campbell IL, Siggins GR. Reduced long-term potentiation in the dentate gyrus of transgenic mice with cerebral overexpression of interleukin-6. Neuroscience Letters. 198: 95-8. PMID 8592650 DOI: 10.1016/0304-3940(95)11976-4  1
1995 Madamba SG, Hsu M, Schweitzer P, Siggins GR. Ethanol enhances muscarinic cholinergic neurotransmission in rat hippocampus in vitro. Brain Research. 685: 21-32. PMID 7583249 DOI: 10.1016/0006-8993(95)00393-5  1
1994 Moore SD, Madamba SG, Schweitzer P, Siggins GR. Voltage-dependent effects of opioid peptides on hippocampal CA3 pyramidal neurons in vitro. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 809-20. PMID 7905518  1
1994 Nie Z, Madamba SG, Siggins GR. Ethanol inhibits glutamatergic neurotransmission in nucleus accumbens neurons by multiple mechanisms. The Journal of Pharmacology and Experimental Therapeutics. 271: 1566-73. PMID 7527857  1
1993 Nie Z, Yuan X, Madamba SG, Siggins GR. Ethanol decreases glutamatergic synaptic transmission in rat nucleus accumbens in vitro: naloxone reversal. The Journal of Pharmacology and Experimental Therapeutics. 266: 1705-12. PMID 8396641  1
1993 Bellinger FP, Madamba S, Siggins GR. Interleukin 1 beta inhibits synaptic strength and long-term potentiation in the rat CA1 hippocampus. Brain Research. 628: 227-34. PMID 8313151 DOI: 10.1016/0006-8993(93)90959-Q  1
1993 Yuan XR, Madamba S, Siggins GR. [The effects of opioid peptides on postsynaptic potentials in slice preparation of nucleus accumbens of rats]. Sheng Li Xue Bao : [Acta Physiologica Sinica]. 45: 528-35. PMID 8146677  1
1993 Schweitzer P, Madamba S, Champagnat J, Siggins GR. Somatostatin inhibition of hippocampal CA1 pyramidal neurons: mediation by arachidonic acid and its metabolites. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 2033-49. PMID 8097529  1
1992 Zeise ML, Madamba S, Siggins GR. Interleukin-1 beta increases synaptic inhibition in rat hippocampal pyramidal neurons in vitro. Regulatory Peptides. 39: 1-7. PMID 1579655 DOI: 10.1016/0167-0115(92)90002-C  1
1992 Pontzer NJ, Madamba S, Siggins GR, Crews FT. Concentrations of carbachol stimulating phosphoinositide hydrolysis cause a sustained decrease in membrane potential and firing rate: role of inositol and inositol polyphosphate second messengers. Brain Research. 597: 189-99. PMID 1335346 DOI: 10.1016/0006-8993(92)91474-S  1
1992 Yuan XR, Madamba S, Siggins GR. Opioid peptides reduce synaptic transmission in the nucleus accumbens. Neuroscience Letters. 134: 223-8. PMID 1317025 DOI: 10.1016/0304-3940(92)90522-9  1
1990 Schweitzer P, Madamba S, Siggins GR. Arachidonic acid metabolites as mediators of somatostatin-induced increase of neuronal M-current. Nature. 346: 464-7. PMID 1974033 DOI: 10.1038/346464a0  1
1990 Moore SD, Madamba SG, Siggins GR. Ethanol diminishes a voltage-dependent K+ current, the M-current, in CA1 hippocampal pyramidal neurons in vitro. Brain Research. 516: 222-8. PMID 1973065 DOI: 10.1016/0006-8993(90)90922-X  1
1990 Joëls M, Madamba SG, Moore SD, Morrison JH, Siggins GR. Somatostatin immunohistochemistry of hippocampal slices with lucifer yellow-stained pyramidal neurons responding to somatostatin. Regulatory Peptides. 28: 215-21. PMID 1693006 DOI: 10.1016/0167-0115(90)90019-S  1
1990 Siggins GR. Electrophysiological actions of opioids on central neurons New Leads in Opioid Research: Proceedings of the International Narcotics Research Conference. Ics914. 293-294.  1
1988 Moore SD, Madamba SG, Zieglgänsberger W, Siggins GR. Enkephalin analogues depress synaptic potentials in rat dentate granule cells recorded intracellularly in vitro. Neuroscience Letters. 91: 71-6. PMID 3050621 DOI: 10.1016/0304-3940(88)90251-0  1
1988 Staunton DA, Svensson TH, Chouvet GE, Siggins GR, Bloom FE. Systemic phenoxybenzamine but not beta-adrenergic antagonists block noradrenergic inhibition of cerebellar Purkinje and hippocampal pyramidal neurons. Journal of Neural Transmission. 73: 101-13. PMID 2905380 DOI: 10.1007/BF01243381  1
1988 Moore SD, Madamba SG, Joëls M, Siggins GR. Somatostatin augments the M-current in hippocampal neurons. Science (New York, N.Y.). 239: 278-80. PMID 2892268  1
1988 Jacquin T, Champagnat J, Madamba S, Denavit-Saubié M, Siggins GR. Somatostatin depresses excitability in neurons of the solitary tract complex through hyperpolarization and augmentation of IM, a non-inactivating voltage-dependent outward current blocked by muscarinic agonists. Proceedings of the National Academy of Sciences of the United States of America. 85: 948-52. PMID 2448787  1
1987 Siggins GR, Pittman QJ, French ED. Effects of ethanol on CA1 and CA3 pyramidal cells in the hippocampal slice preparation: an intracellular study. Brain Research. 414: 22-34. PMID 3620923 DOI: 10.1016/0006-8993(87)91323-0  1
1987 Siggins GR, Bloom FE, French ED, Madamba SG, Mancillas J, Pittman QJ, Rogers J. Electrophysiology of ethanol on central neurons. Annals of the New York Academy of Sciences. 492: 350-66. PMID 3474932 DOI: 10.1111/j.1749-6632.1987.tb48692.x  1
1987 Bloom FE, Siggins GR. Electrophysiological action of ethanol at the cellular level. Alcohol (Fayetteville, N.Y.). 4: 331-7. PMID 3304331 DOI: 10.1016/0741-8329(87)90031-0  1
1986 Rogers J, Madamba SG, Staunton DA, Siggins GR. Ethanol increases single unit activity in the inferior olivary nucleus. Brain Research. 385: 253-62. PMID 3779391 DOI: 10.1016/0006-8993(86)91071-1  1
1986 Siggins GR, Henriksen SJ, Chavkin C, Gruol D. Opioid peptides and epileptogenesis in the limbic system: cellular mechanisms. Advances in Neurology. 44: 501-12. PMID 2939697  1
1986 Mancillas JR, Siggins GR, Bloom FE. Somatostatin selectively enhances acetylcholine-induced excitations in rat hippocampus and cortex. Proceedings of the National Academy of Sciences of the United States of America. 83: 7518-21. PMID 2876428  1
1986 Mancillas JR, Siggins GR, Bloom FE. Systemic ethanol: selective enhancement of responses to acetylcholine and somatostatin in hippocampus. Science (New York, N.Y.). 231: 161-3. PMID 2867600  1
1985 Ferron A, Siggins GR, Bloom FE. Vasoactive intestinal polypeptide acts synergistically with norepinephrine to depress spontaneous discharge rate in cerebral cortical neurons. Proceedings of the National Academy of Sciences of the United States of America. 82: 8810-2. PMID 3866254  1
1985 Siggins GR, Gruol D, Aldenhoff J, Pittman Q. Electrophysiological actions of corticotropin-releasing factor in the central nervous system. Federation Proceedings. 44: 237-42. PMID 3155696  1
1985 Champagnat J, Siggins GR, Koda LY, Denavit-Saubié M. Synaptic responses of neurons of the nucleus tractus solitarius in vitro. Brain Research. 325: 49-56. PMID 2983833 DOI: 10.1016/0006-8993(85)90301-4  1
1985 Bloom FE, Battenberg E, Ferron A, Mancillas JR, Milner RJ, Siggins G, Sutcliffe JG. Neuropeptides: interactions and diversities. Recent Progress in Hormone Research. 41: 339-67. PMID 2864725  1
1985 Chavkin C, Henriksen SJ, Siggins GR, Bloom FE. Selective inactivation of opioid receptors in rat hippocampus demonstrates that dynorphin-A and -B may act on mu-receptors in the CA1 region. Brain Research. 331: 366-70. PMID 2859095 DOI: 10.1016/0006-8993(85)91565-3  1
1983 Champagnat J, Denavit-Saubie M, Siggins GR. Rhythmic neuronal activities in the nucleus of the tractus solitarius isolated in vitro. Brain Research. 280: 155-9. PMID 6652474 DOI: 10.1016/0006-8993(83)91184-8  1
1983 Aldenhoff JB, Gruol DL, Rivier J, Vale W, Siggins GR. Corticotropin releasing factor decreases postburst hyperpolarizations and excites hippocampal neurons. Science (New York, N.Y.). 221: 875-7. PMID 6603658 DOI: 10.1126/science.6603658  1
1983 Gruol DL, Chavkin C, Valentino RJ, Siggins GR. Dynorphin-A alters the excitability of pyramidal neurons of the rat hippocampus in vitro. Life Sciences. 33: 533-6. PMID 6141499 DOI: 10.1016/0024-3205(83)90558-1  1
1982 Berger T, French ED, Siggins GR, Shier WT, Bloom FE. Ethanol and some tetrahydroisoquinolines alter the discharge of cortical and hippocampal neurons: relationship to endogenous opioids. Pharmacology, Biochemistry, and Behavior. 17: 813-21. PMID 7178189 DOI: 10.1016/0091-3057(82)90365-3  1
1982 Schultz JE, Siggins GR, Türck M, Bloom FE. Electrophysiological and biochemical comparison of the acute and chronic effects of lithium and tricyclic antidepressants. Advances in Biochemical Psychopharmacology. 31: 347-57. PMID 6282062  1
1982 Siggins GR, McGinty JF, Morrison JH, Pittman QJ, Zieglgänsberger W, Magistretti PJ, Gruol DL. The role of neuropeptides in the hippocampal formation. Advances in Biochemical Psychopharmacology. 33: 413-22. PMID 6127004  1
1982 Siggins GR, Berger T, French ED, Shier T, Bloom FE. Ethanol, salsolinol and tetrahydropapaveroline alter the discharge of neurons in several brain regions: comparison to opioid effects. Progress in Clinical and Biological Research. 90: 275-87. PMID 6125947  1
1981 Siggins GR, Zieglgänsberger W. Morphine and opioid peptides reduce inhibitory synaptic potentials in hippocampal pyramidal cells in vitro without alteration of membrane potential. Proceedings of the National Academy of Sciences of the United States of America. 78: 5235-9. PMID 6272296  1
1981 Siggins GR, Schubert P. Adenosine depression of hippocampal neurons in vitro: an intracellular study of dose-dependent actions on synaptic and membrane potentials. Neuroscience Letters. 23: 55-60. PMID 6262683 DOI: 10.1016/0304-3940(81)90186-5  1
1981 Bloom FE, Siggins GR, Henriksen SJ. Electrophysiologic assessment of receptor changes following chronic drug treatment. Federation Proceedings. 40: 166-72. PMID 6257556  1
1981 Schultz JE, Siggins GR, Schocker FW, Türck M, Bloom FE. Effects of prolonged treatment with lithium and tricyclic antidepressants on discharge frequency, norepinephrine responses and beta receptor binding in rat cerebellum: electrophysiological and biochemical comparison. The Journal of Pharmacology and Experimental Therapeutics. 216: 28-38. PMID 6256526  1
1981 Gruol DL, Siggins GR, Padjen AL, Forman DS. Explant cultures of adult amphibian sympathetic ganglia: electrophysiological and pharmacological investigation of neurotransmitter and nucleotide action. Brain Research. 223: 81-106. PMID 6116525 DOI: 10.1016/0006-8993(81)90808-8  1
1981 Pittman QJ, Siggins GR. Somatostatin hyperpolarizes hippocampal pyramidal cells in vitro. Brain Research. 221: 402-8. PMID 6116516 DOI: 10.1016/0006-8993(81)90791-5  1
1980 Bloom FE, Rogers J, Schulman JA, Schultz J, Siggins GR. Inferential changes after chronic treatments with Li, DMI, or ethanol detected by electrophysiological correlates [proceedings]. Psychopharmacology Bulletin. 16: 19-20. PMID 7454923  1
1980 Rogers J, Siggins GR, Schulman JA, Bloom FE. Physiological correlates of ethanol intoxication tolerance, and dependence in rat cerebellar Purkinje cells. Brain Research. 196: 183-98. PMID 7190454 DOI: 10.1016/0006-8993(80)90725-8  1
1980 Siggins GR, Bloom FE. Alcohol-related electrophysiology. Pharmacology, Biochemistry, and Behavior. 13: 203-11. PMID 7017760  1
1980 French ED, Siggins GR. An iontophoretic survey of opioid peptide actions in the rat limbic system: in search of opiate epileptogenic mechanisms. Regulatory Peptides. 1: 127-46. PMID 6265978 DOI: 10.1016/0167-0115(80)90016-6  1
1980 Bloom FE, Schultz JE, Siggins GR, Henriksen SJ. Catecholamine transmitter systems [proceedings]. Psychopharmacology Bulletin. 16: 35-6. PMID 6102400  1
1980 Pittman QJ, Siggins GR. Somatostatin (SS) hyperpolarizes hippocampal (HPC) pyramidal neurons in vitro Physiologist. 23: No. 365.  1
1979 Siggins GR, French E. Central neurons are depressed by iontophoretic and micropressure application of ethanol and tetrahydropapaveroline. Drug and Alcohol Dependence. 4: 239-43. PMID 527479 DOI: 10.1016/0376-8716(79)90004-8  1
1979 Zieglgänsberger W, French ED, Siggins GR, Bloom FE. Opioid peptides may excite hippocampal pyramidal neurons by inhibiting adjacent inhibitory interneurons. Science (New York, N.Y.). 205: 415-7. PMID 451610  1
1979 Siggins GR, Henriksen SJ, Bloom F. Iontophoresis of Li+ antagonizes noradrenergic synaptic inhibition of rat cerebellar Purkinje cells. Proceedings of the National Academy of Sciences of the United States of America. 76: 3015-8. PMID 288083  1
1979 Siggins GR. Cyclic nucleotides in the development of alcohol tolerance and dependence: a commentary. Drug and Alcohol Dependence. 4: 307-19. PMID 230950 DOI: 10.1016/0376-8716(79)90013-9  1
1979 Siggins GR, Schultz JE. Chronic treatment with lithium or desipramine alters discharge frequency and norepinephrine responsiveness of cerebellar Purkinje cells. Proceedings of the National Academy of Sciences of the United States of America. 76: 5987-91. PMID 230496  1
1979 Siggins GR. The role of catecholamines and opiate peptides with particular reference to the striatum. Applied Neurophysiology. 42: 60-1. PMID 222208 DOI: 10.1159/000102339  1
1979 Siggins GR. Neurotransmitters and neuromodulators and their mediation by cyclic nucleotides. Advances in Experimental Medicine and Biology. 116: 41-64. PMID 38646  1
1978 Bloom FE, Rossier J, Battenberg EL, Bayon A, French E, Henriksen SJ, Siggins GR, Segal D, Browne R, Ling N, Guillemin R. beta-endorphin: cellular localization, electrophysiological and behavioral effects. Advances in Biochemical Psychopharmacology. 18: 89-109. PMID 77124  1
1978 Schultz J, Schocker W, Siggins GR. Mechanism of action of tricyclic antidepresants: Biochemical and electrophysiological studies Hoppe-Seyler's Zeitschrift Fur Physiologische Chemie. 359: 462-463.  1
1978 Zieglgaensberger W, French E, Siggins GR, Bloom F. Opiates and opioid peptides may cause excitation of hippocampal pyramidal neurons (HPN) by disinhibition Pflugers Archiv European Journal of Physiology. 377: R34.  1
1977 Nicoll RA, Siggins GR, Ling N, Bloom FE, Guillemin R. Neuronal actions of endorphins and enkephalins among brain regions: a comparative microiontophoretic study. Proceedings of the National Academy of Sciences of the United States of America. 74: 2584-8. PMID 267951  1
1977 Siggins GR, Gruol DL, Padjen AL, Formans DS. Purine and pyrimidine mononucleotides depolarise neurones of explanted amphibian sympathetic ganglia. Nature. 270: 263-5. PMID 201858 DOI: 10.1038/270263a0  1
1977 Forman DS, Padjen AL, Siggins GR. Effect of temperature on the rapid retrograde transport of microscopically visible intra-axonal organelles. Brain Research. 136: 215-26. PMID 72585 DOI: 10.1016/0006-8993(77)90799-5  1
1977 Forman DS, Padjen AL, Siggins GR. Axonal transport of organelles visualized by light microscopy: cinemicrographic and computer analysis. Brain Research. 136: 197-213. PMID 72584 DOI: 10.1016/0006-8993(77)90798-3  1
1976 Siggins GR, Hoffer BJ, Bloom FE, Ungerstedt U. Cytochemical and electrophysiological studies of dopamine in the caudate nucleus. Research Publications - Association For Research in Nervous and Mental Disease. 55: 227-48. PMID 188086  1
1976 Siggins GR, Henriksen SJ, Landis SC. Electrophysiology of Purkinje neurons in the weaver mouse: iontophoresis of neurotransmitters and cyclic nucleotides, and stimulation of the nucleus locus coeruleus. Brain Research. 114: 53-69. PMID 183862 DOI: 10.1016/0006-8993(76)91007-6  1
1975 Hoffer BJ, Siggins GR. Electrophysiological techniques for the study of hormone action in the central nervous system. Methods in Enzymology. 39: 429-40. PMID 239301 DOI: 10.1016/S0076-6879(75)39038-1  1
1975 Siggins GR, Henriksen SJ. Analogs of cyclic adenosine monophosphate: correlation of inhibition of Purkinje Neurons with Protein Kinase Activation. Science (New York, N.Y.). 189: 559-61. PMID 167439  1
1975 Bloom FE, Siggins GR, Hoffer BJ, Segal M, Oliver AP. Cyclic nucleotdides in the central synaptic actions of catecholamines. Advances in Cyclic Nucleotide Research. 5: 603-18. PMID 165689  1
1975 Shoemaker WJ, Balentine LT, Siggins GR, Hoffer BJ, Henriksen SJ, Bloom FE. Characteristics of the release of adenosine 3':5'-monophosphate from micropipets by microiontophoresis. Journal of Cyclic Nucleotide Research. 1: 97-106. PMID 4474  1
1974 Siggins GR, Hoffer BJ, Ungerstedt U. Electrophysiological evidence for involvement of cyclic adenosine monophosphate in dopamine responses of caudate neurons. Life Sciences. 15: 779-92. PMID 4378085 DOI: 10.1016/0024-3205(74)90298-7  1
1974 Bloom FE, Siggins GR, Hoffer BJ. Interpreting the failures to confirm the depression of cerebellar Purkinje cells by cyclic AMP. Science (New York, N.Y.). 185: 627-9. PMID 4366788  1
1974 Freedman R, Siggins GR. Effect of phenothiazines on catecholamine inhibition in rat cerebellum and caudate Federation Proceedings. 33: No. 242.  1
1973 Siggins GR, Forman DS. Degenerative effects of 6-aminodopamine and 6-hydroxydopamine on peripheral adrenergic nerves. Zeitschrift FüR Zellforschung Und Mikroskopische Anatomie (Vienna, Austria : 1948). 146: 339-49. PMID 4544341 DOI: 10.1007/BF02346226  1
1973 Bloom FE, Chu N, Hoffer BJ, Nelson CN, Siggins GR. Studies on the function of central noradrenergic neurons. Neurosciences Research. 5: 53-72. PMID 4366084  1
1973 Hoffer BJ, Siggins GR, Oliver AP, Bloom FE. Activation of the pathway from locus coeruleus to rat cerebellar Purkinje neurons: pharmacological evidence of noradrenergic central inhibition. The Journal of Pharmacology and Experimental Therapeutics. 184: 553-69. PMID 4347049  1
1973 Siggins GR, Battenberg EF, Hoffer BJ, Bloom FE, Steiner AL. Noradrenergic stimulation of cyclic adenosine monophosphate in rat Purkinje neurons: an immunocytochemical study. Science (New York, N.Y.). 179: 585-8. PMID 4346826  1
1973 Siggins GR, Forman DS, Bloom FE. Destruction of peripheral and central adrenergic nerves by 6 amino dopamine (6 ADA) Federation Proceedings. 32: I.  1
1972 Hoffer BJ, Siggins GR, Oliver AP, Bloom FE. Cyclic AMP-mediated adrenergic synapses to cerebellar Purkinje cells. Advances in Cyclic Nucleotide Research. 1: 411-23. PMID 4353180  1
1972 Bloom FE, Hoffer BJ, Battenberg ER, Siggins GR, Steiner AL, Parker CW, Wedner HJ. Adenosine 3',5'-monophosphate is localized in cerebellar neurons: immunofluorescence evidence. Science (New York, N.Y.). 177: 436-8. PMID 4339615  1
1972 Bloom FE, Hoffer BJ, Siggins GR. Norepinephrine mediated cerebellar synapses: a model system for neuropsychopharmacology. Biological Psychiatry. 4: 157-77. PMID 4337435  1
1972 Bloom FE, Hoffer BJ, Siggins GR, Barker JL, Nicoll RA. Effects of serotonin on central neurons: microiontophoretic administration. Federation Proceedings. 31: 97-106. PMID 4333253  1
1971 Bloom FE, Hoffer BJ, Siggins GR. Studies on norepinephrine-containing afferents to Purkinje cells of art cerebellum. I. Localization of the fibers and their synapses. Brain Research. 25: 501-21. PMID 5544323 DOI: 10.1016/0006-8993(71)90457-4  1
1971 Hoffer BJ, Neff NH, Siggins GR. Microiontophoretic release of norepinephrine from micropipettes. Neuropharmacology. 10: 175-80. PMID 5093958 DOI: 10.1016/0028-3908(71)90038-4  1
1971 Siggins GR, Hoffer BJ, Oliver AP, Bloom FE. Activation of a central noradrenergic projection to cerebellum. Nature. 233: 481-3. PMID 4939543 DOI: 10.1038/233481a0  1
1971 Hoffer BJ, Siggins GR, Bloom FE. Studies on norepinephrine-containing afferents to Purkinje cells of rat cerebellum. II. Sensitivity of Purkinje cells to norepinephrine and related substances administered by microiontophoresis. Brain Research. 25: 523-34. PMID 4395919 DOI: 10.1016/0006-8993(71)90458-6  1
1971 Godfraind JM, Pumain R, Siggins GR, Hoffer BJ, Bloom FE. Cyclic adenosine monophosphate and norepinephrine: effect on purkinje cells in rat cerebellar cortex. Science (New York, N.Y.). 174: 1257-9. PMID 4332286  1
1971 Woodward DJ, Hoffer BJ, Siggins GR, Bloom FE. The ontogenetic development of synaptic junctions, synaptic activation and responsiveness to neurotransmitter substances in rat cerebellar purkinje cells. Brain Research. 34: 73-97. PMID 4330971 DOI: 10.1016/0006-8993(71)90352-0  1
1971 Hoffer BJ, Siggins GR, Oliver AP, Bloom FE. Cyclic AMP mediation of norepinephrine inhibition in rat cerebellar cortex: a unique class of synaptic responses. Annals of the New York Academy of Sciences. 185: 531-49. PMID 4330518  1
1971 Woodward DJ, Hoffer BJ, Siggins GR, Oliver AP. Inhibition of Purkinje cells in the frog cerebellum. II. Evidence for GABA as the inhibitory transmitter. Brain Research. 33: 91-100. PMID 4330216 DOI: 10.1016/0006-8993(71)90308-8  1
1971 Hoffer BJ, Siggins GR, Woodward DJ, Bloom FE. Spontaneous discharge of Purkinje neurons after destruction of catecholamine-containing afferents by 6-hydroxydopamine. Brain Research. 30: 425-30. PMID 4329214 DOI: 10.1016/0006-8993(71)90095-3  1
1971 Siggins GR, Hoffer BJ, Bloom FE. Studies on norepinephrine-containing afferents to Purkinje cells of rat cerebellum. 3. Evidence for mediation of norepinephrine effects by cyclic 3',5'-adenosine monophosphate. Brain Research. 25: 535-53. PMID 4322679 DOI: 10.1016/0006-8993(71)90459-8  1
1971 Siggins GR, Oliver AP, Hoffer BJ, Bloom FE. Cyclic adenosine monophosphate and norepinephrine: effects on transmembrane properties of cerebellar Purkinje cells. Science (New York, N.Y.). 171: 192-4. PMID 4322158  1
1971 Siggins GR, Weitsen HA. Cytochemical and physiological evidence for cholinergic, neurogenic vasodilation of amphibian arterioles and precapillary sphincters. I. Light microscopy. Microvascular Research. 3: 308-22. PMID 4106944 DOI: 10.1016/0026-2862(71)90056-2  1
1970 Siggins GR, Bloom FE. Cytochemical and physiological effects of 6-hydroxydopamine on periarteriolar nerves of frogs. Circulation Research. 27: 23-38. PMID 5424564  1
1970 Hoffer BJ, Siggins GR, Bloom FE. Possible cyclic AMP-mediated adrenergic synapses to rat cerebellar Purkinje cells: combined structural, physiological, and pharmacological analyses. Advances in Biochemical Psychopharmacology. 3: 349-70. PMID 4331463  1
1969 Hoffer BJ, Siggins GR, Bloom FE. Prostaglandins E1 and E2 antagonize norepinephrine effects on cerebellar purkinje cells: microelectrophoretic study. Science (New York, N.Y.). 166: 1418-20. PMID 5350346  1
1969 Siggins GR, Hoffer BJ, Bloom FE. Cyclic adenosine monophosphate: possible mediator for norepinephrine effects on cerebellar Purkinje cells. Science (New York, N.Y.). 165: 1018-20. PMID 4308638  1
1968 Berman HJ, Siggins GR. Neurogenic factors in the microvascular system. Federation Proceedings. 27: 1384-90. PMID 5725230  1
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