Year |
Citation |
Score |
2023 |
Latif-Hernandez A, Yang T, Raymond-Butler R, Losada PM, Minhas P, White H, Tran KC, Liu H, Simmons DA, Langness V, Andreasson K, Wyss-Coray T, Longo FM. A TrkB and TrkC partial agonist restores deficits in synaptic function and promotes activity-dependent synaptic and microglial transcriptomic changes in a late-stage Alzheimer's mouse model. Biorxiv : the Preprint Server For Biology. PMID 37781573 DOI: 10.1101/2023.09.18.558138 |
0.536 |
|
2023 |
Simmons DA, Belichenko NP, Longo FM. Pharmacological Co-Activation of TrkB and TrkC Receptor Signaling Ameliorates Striatal Neuropathology and Motor Deficits in Mouse Models of Huntington's Disease. Journal of Huntington's Disease. PMID 37638447 DOI: 10.3233/JHD-230589 |
0.578 |
|
2021 |
Gonzalez S, McHugh TLM, Yang T, Syriani W, Massa SM, Longo FM, Simmons DA. Small molecule modulation of TrkB and TrkC neurotrophin receptors prevents cholinergic neuron atrophy in an Alzheimer's disease mouse model at an advanced pathological stage. Neurobiology of Disease. 105563. PMID 34838668 DOI: 10.1016/j.nbd.2021.105563 |
0.607 |
|
2021 |
Simmons DA, Mills BD, Butler Iii RR, Kuan J, McHugh TLM, Akers C, Zhou J, Syriani W, Grouban M, Zeineh M, Longo FM. Neuroimaging, Urinary, and Plasma Biomarkers of Treatment Response in Huntington's Disease: Preclinical Evidence with the p75 Ligand LM11A-31. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 33786806 DOI: 10.1007/s13311-021-01023-8 |
0.533 |
|
2019 |
Mufson EJ, Counts SE, Ginsberg SD, Mahady L, Perez SE, Massa SM, Longo FM, Ikonomovic MD. Nerve Growth Factor Pathobiology During the Progression of Alzheimer's Disease. Frontiers in Neuroscience. 13: 533. PMID 31312116 DOI: 10.3389/fnins.2019.00533 |
0.314 |
|
2019 |
Simmons DA, Lartey FM, Schüler E, Rafat M, King G, Kim A, Ko R, Semaan S, Gonzalez S, Jenkins M, Pradhan P, Shih Z, Wang J, von Eyben R, Graves EE, ... ... Longo FM, et al. Reduced cognitive deficits after FLASH irradiation of whole mouse brain are associated with less hippocampal dendritic spine loss and neuroinflammation. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. PMID 31253467 DOI: 10.1016/J.Radonc.2019.06.006 |
0.498 |
|
2019 |
Boakye PA, Rancic V, Whitlock KH, Simmons D, Longo FM, Ballanyi K, Smith PA. Receptor-dependence of BDNF Actions in Superficial Dorsal Horn; Relation to Central Sensitization and Actions of Macrophage Colony Stimulating Factor 1 (CSF-1). Journal of Neurophysiology. PMID 30995156 DOI: 10.1152/Jn.00839.2018 |
0.604 |
|
2018 |
Simmons DA, James ML, Belichenko NP, Semaan S, Condon C, Kuan J, Shuhendler AJ, Miao Z, Chin FT, Longo FM. TSPO-PET Imaging Using [18F]PBR06 is a Potential Translatable Biomarker for Treatment Response in Huntington's Disease: Preclinical Evidence with the p75NTR Ligand LM11A-31. Human Molecular Genetics. PMID 29860333 DOI: 10.1093/Hmg/Ddy202 |
0.514 |
|
2016 |
Simmons DA, Belichenko NP, Ford EC, Semaan S, Monbureau M, Aiyaswamy S, Holman CM, Condon C, Shamloo M, Massa SM, Longo FM. A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice. Human Molecular Genetics. 25: 4920-4938. PMID 28171570 DOI: 10.1093/Hmg/Ddw316 |
0.572 |
|
2016 |
Simmons DA, Longo FM, Massa SM. Neurotrophin receptor signaling as a therapeutic target for Huntington's Disease. Cns & Neurological Disorders Drug Targets. PMID 27823570 DOI: 10.2174/1871527315666161107093047 |
0.551 |
|
2016 |
Simmons DA, Belichenko NP, Ford EC, Semaan S, Monbureau M, Aiyaswamy S, Holman CM, Condon C, Shamloo M, Massa SM, Longo FM. A small molecule p75NTR ligand normalizes signaling and reduces Huntington's Disease phenotypes in R6/2 and BACHD mice. Human Molecular Genetics. PMID 27638888 DOI: 10.1093/hmg/ddw316 |
0.575 |
|
2016 |
Yang T, Massa SM, Tran KC, Simmons DA, Rajadas J, Zeng AY, Jang T, Carsanaro S, Longo FM. A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth. Neuropharmacology. PMID 27334657 DOI: 10.1016/J.Neuropharm.2016.06.015 |
0.703 |
|
2015 |
Malkovskiy AV, Wagh DA, Longo FM, Rajadas J. A strategy for analyzing bond strength and interaction kinetics between Pleckstrin homology domains and PI(4,5)P2 phospholipids using force distance spectroscopy and surface plasmon resonance. The Analyst. 140: 4558-65. PMID 26040325 DOI: 10.1039/C5An00498E |
0.484 |
|
2014 |
Friesland A, Weng Z, Duenas M, Massa SM, Longo FM, Lu Q. Amelioration of cisplatin-induced experimental peripheral neuropathy by a small molecule targeting p75 NTR. Neurotoxicology. 45: 81-90. PMID 25277379 DOI: 10.1016/j.neuro.2014.09.005 |
0.3 |
|
2014 |
Simmons DA, Knowles JK, Belichenko NP, Banerjee G, Finkle C, Massa SM, Longo FM. A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression. Plos One. 9: e102136. PMID 25153701 DOI: 10.1371/journal.pone.0102136 |
0.566 |
|
2014 |
Villeda SA, Plambeck KE, Middeldorp J, Castellano JM, Mosher KI, Luo J, Smith LK, Bieri G, Lin K, Berdnik D, Wabl R, Udeochu J, Wheatley EG, Zou B, Simmons DA, ... ... Longo FM, et al. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nature Medicine. 20: 659-63. PMID 24793238 DOI: 10.1038/Nm.3569 |
0.499 |
|
2013 |
Simmons DA, Belichenko NP, Yang T, Condon C, Monbureau M, Shamloo M, Jing D, Massa SM, Longo FM. A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 18712-27. PMID 24285878 DOI: 10.1523/Jneurosci.1310-13.2013 |
0.59 |
|
2013 |
Knowles JK, Simmons DA, Nguyen TV, Vander Griend L, Xie Y, Zhang H, Yang T, Pollak J, Chang T, Arancio O, Buckwalter MS, Wyss-Coray T, Massa SM, Longo FM. Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model. Neurobiology of Aging. 34: 2052-63. PMID 23545424 DOI: 10.1016/J.Neurobiolaging.2013.02.015 |
0.584 |
|
2013 |
Longo F, Nguyen T, Simmons D, Yang T, Knowles J, Zhang H, Arancio O, Massa S, Longo F. S4-02-04: Targeting Alzheimer's disease-related mechanisms with p75 ligands Alzheimer's & Dementia. 9: P674-P674. DOI: 10.1016/J.Jalz.2013.04.323 |
0.559 |
|
2010 |
Massa SM, Yang T, Xie Y, Shi J, Bilgen M, Joyce JN, Nehama D, Rajadas J, Longo FM. Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents. The Journal of Clinical Investigation. 120: 1774-85. PMID 20407211 DOI: 10.1172/Jci41356 |
0.593 |
|
2009 |
Knowles JK, Rajadas J, Nguyen TV, Yang T, LeMieux MC, Vander Griend L, Ishikawa C, Massa SM, Wyss-Coray T, Longo FM. The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 10627-37. PMID 19710315 DOI: 10.1523/Jneurosci.0620-09.2009 |
0.552 |
|
2008 |
Yang T, Knowles JK, Lu Q, Zhang H, Arancio O, Moore LA, Chang T, Wang Q, Andreasson K, Rajadas J, Fuller GG, Xie Y, Massa SM, Longo FM. Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment. Plos One. 3: e3604. PMID 18978948 DOI: 10.1371/Journal.Pone.0003604 |
0.57 |
|
1997 |
Longo FM, Manthorpe M, Xie YM, Varon S. Synthetic NGF peptide derivatives prevent neuronal death via a p75 receptor-dependent mechanism. Journal of Neuroscience Research. 48: 1-17. PMID 9086177 DOI: 10.1002/(Sici)1097-4547(19970401)48:1<1::Aid-Jnr1>3.0.Co;2-K |
0.656 |
|
1989 |
Fields RD, Le Beau JM, Longo FM, Ellisman MH. Nerve regeneration through artificial tubular implants. Progress in Neurobiology. 33: 87-134. PMID 2678271 DOI: 10.1016/0301-0082(89)90036-1 |
0.588 |
|
1984 |
Longo FM, Selak I, Zovickian J, Manthorpe M, Varon S, U HS. Neuronotrophic activities in cerebrospinal fluid of head trauma patients. Experimental Neurology. 84: 207-18. PMID 6705885 DOI: 10.1016/0014-4886(84)90016-5 |
0.669 |
|
1984 |
Longo FM, Hayman EG, Davis GE, Ruoslahti E, Engvall E, Manthorpe M, Varon S. Neurite-promoting factors and extracellular matrix components accumulating in vivo within nerve regeneration chambers. Brain Research. 309: 105-17. PMID 6488001 DOI: 10.1016/0006-8993(84)91014-X |
0.676 |
|
1983 |
Longo FM, Skaper SD, Manthorpe M, Williams LR, Lundborg G, Varon S. Temporal changes of neuronotrophic activities accumulating in vivo within nerve regeneration chambers. Experimental Neurology. 81: 756-69. PMID 6884483 DOI: 10.1016/0014-4886(83)90342-4 |
0.668 |
|
1983 |
Manthorpe M, Luyten W, Longo FM, Varon S. Endogenous and exogenous factors support neuronal survival and choline acetyltransferase activity in embryonic spinal cord cultures. Brain Research. 267: 57-66. PMID 6860950 DOI: 10.1016/0006-8993(83)91039-9 |
0.665 |
|
1983 |
Longo FM, Manthorpe M, Skaper SD, Lundborg G, Varon S. Neuronotrophic activities accumulate in vivo within silicone nerve regeneration chambers. Brain Research. 261: 109-16. PMID 6839146 DOI: 10.1016/0006-8993(83)91289-1 |
0.653 |
|
1983 |
Manthorpe M, Engvall E, Ruoslahti E, Longo FM, Davis GE, Varon S. Laminin promotes neuritic regeneration from cultured peripheral and central neurons. The Journal of Cell Biology. 97: 1882-90. PMID 6643580 DOI: 10.1083/Jcb.97.6.1882 |
0.689 |
|
1983 |
Williams LR, Longo FM, Powell HC, Lundborg G, Varon S. Spatial-temporal progress of peripheral nerve regeneration within a silicone chamber: parameters for a bioassay. The Journal of Comparative Neurology. 218: 460-70. PMID 6619324 DOI: 10.1002/Cne.902180409 |
0.48 |
|
1982 |
Lundborg G, Dahlin LB, Danielsen N, Hansson HA, Johannesson A, Longo FM, Varon S. Nerve regeneration across an extended gap: a neurobiological view of nerve repair and the possible involvement of neuronotrophic factors. The Journal of Hand Surgery. 7: 580-7. PMID 7175129 DOI: 10.1016/S0363-5023(82)80107-X |
0.495 |
|
1982 |
Manthorpe M, Longo FM, Varon S. Comparative features of spinal neuronotrophic factors in fluids collected in vitro and in vivo. Journal of Neuroscience Research. 8: 241-50. PMID 7154113 DOI: 10.1002/Jnr.490080214 |
0.66 |
|
1982 |
Nieto-Sampedro M, Lewis ER, Cotman CW, Manthorpe M, Skaper SD, Barbin G, Longo FM, Varon S. Brain injury causes a time-dependent increase in neuronotrophic activity at the lesion site. Science (New York, N.Y.). 217: 860-1. PMID 7100931 DOI: 10.1126/Science.7100931 |
0.667 |
|
1982 |
Lundborg G, Gelberman RH, Longo FM, Powell HC, Varon S. In vivo regeneration of cut nerves encased in silicone tubes: growth across a six-millimeter gap. Journal of Neuropathology and Experimental Neurology. 41: 412-22. PMID 7086464 DOI: 10.1097/00005072-198207000-00004 |
0.494 |
|
1982 |
Longo FM, Manthorpe M, Varon S. Spinal cord neuronotrophic factors (SCNTFs): I. Bioassay of schwannoma and other conditioned media. Brain Research. 255: 277-94. PMID 7055725 DOI: 10.1016/0165-3806(82)90027-X |
0.672 |
|
1982 |
Lundborg G, Longo FM, Varon S. Nerve regeneration model and trophic factors in vivo. Brain Research. 232: 157-61. PMID 7055692 DOI: 10.1016/0006-8993(82)90618-7 |
0.541 |
|
1982 |
Longo FM, Lundborg G, Varon S, Powell HC. NERVE REGENERATION IN SILICONE CHAMBERS Journal of Neuropathology and Experimental Neurology. 41: 372. DOI: 10.1097/00005072-198205000-00103 |
0.47 |
|
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