Pamela J. Lein - Publications

University of California, Davis, Davis, CA 
developmental neurobiology, dendrites

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Year Citation  Score
2019 Yang J, Bruun DA, Wang C, Wan D, Reynolds CB, Phu K, Inceoglu B, Lein PJ, Hammock BD. Lipidomes of brain from rats acutely intoxicated with diisopropylfluorophosphate identifies potential therapeutic targets. Toxicology and Applied Pharmacology. 114749. PMID 31521729 DOI: 10.1016/j.taap.2019.114749  0.76
2019 Rude KM, Pusceddu MM, Keogh CE, Sladek JA, Rabasa G, Miller EN, Sethi S, Keil KP, Pessah IN, Lein PJ, Gareau MG. Developmental exposure to polychlorinated biphenyls (PCBs) in the maternal diet causes host-microbe defects in weanling offspring mice. Environmental Pollution (Barking, Essex : 1987). 253: 708-721. PMID 31336350 DOI: 10.1016/j.envpol.2019.07.066  0.8
2019 Karey E, Pan S, Morris AN, Bruun DA, Lein PJ, Chen CY. The Use of Percent Change in RR Interval for Data Exclusion in Analyzing 24-h Time Domain Heart Rate Variability in Rodents. Frontiers in Physiology. 10: 693. PMID 31244671 DOI: 10.3389/fphys.2019.00693  0.76
2019 Pravoverov K, Whiting K, Thapa S, Bushong T, Trang K, Lein PJ, Chandrasekaran V. MicroRNAs are Necessary for BMP-7-induced Dendritic Growth in Cultured Rat Sympathetic Neurons. Cellular and Molecular Neurobiology. PMID 31104181 DOI: 10.1007/s10571-019-00688-2  0.48
2019 Hobson BA, Rowland DJ, Sisó S, Guignet MA, Harmany ZT, Bandara S, Saito N, Harvey DJ, Bruun DA, Garbow JR, Chaudhari AJ, Lein PJ. TSPO PET Using [18F]PBR111 Reveals Persistent Neuroinflammation Following Acute Diisopropylfluorophosphate Intoxication in the Rat. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 31087103 DOI: 10.1093/toxsci/kfz096  0.76
2019 Proskocil BJ, Grodzki ACG, Jacoby DB, Lein PJ, Fryer AD. Organophosphorus Pesticides Induce Cytokine Release from Differentiated Human THP1 Cells. American Journal of Respiratory Cell and Molecular Biology. PMID 30978295 DOI: 10.1165/rcmb.2018-0257OC  1
2019 Pessah IN, Lein PJ, Seegal RF, Sagiv SK. Neurotoxicity of polychlorinated biphenyls and related organohalogens. Acta Neuropathologica. PMID 30976975 DOI: 10.1007/s00401-019-01978-1  0.8
2019 Guignet M, Dhakal K, Flannery BM, Hobson BA, Zolkowska D, Dhir A, Bruun DA, Li S, Wahab A, Harvey DJ, Silverman JL, Rogawski MA, Lein PJ. Persistent behavior deficits, neuroinflammation, and oxidative stress in a rat model of acute organophosphate intoxication. Neurobiology of Disease. PMID 30905768 DOI: 10.1016/j.nbd.2019.03.019  0.76
2019 Bruun DA, Guignet M, Harvey DJ, Lein PJ. Pretreatment with pyridostigmine bromide has no effect on seizure behavior or 24 hour survival in the rat model of acute diisopropylfluorophosphate intoxication. Neurotoxicology. PMID 30853371 DOI: 10.1016/j.neuro.2019.03.001  0.76
2019 Sethi S, Morgan R, Feng W, Lin Y, Li X, Luna C, Koch M, Bansal R, Duffel MW, Puschner B, Zoeller TR, Lehmler HJ, Pessah IN, Lein PJ. Comparative analyses of the 12 most abundant PCB congeners detected in human maternal serum for activity at the thyroid hormone receptor and ryanodine receptor. Environmental Science & Technology. PMID 30821444 DOI: 10.1021/acs.est.9b00535  0.8
2018 Keil KP, Sethi S, Wilson MD, Silverman JL, Pessah IN, Lein PJ. Genetic mutations in Ca signaling alter dendrite morphology and social approach in juvenile mice. Genes, Brain, and Behavior. e12526. PMID 30311737 DOI: 10.1111/gbb.12526  0.8
2018 Shaffo FC, Grodzki AC, Fryer AD, Lein PJ. Mechanisms of Organophosphorus Pesticide Toxicity in the Context of Airway Hyperreactivity and Asthma. American Journal of Physiology. Lung Cellular and Molecular Physiology. PMID 29952220 DOI: 10.1152/ajplung.00211.2018  0.76
2018 Miller GW, Chandrasekaran V, Yaghoobi B, Lein PJ. Opportunities and challenges for using the zebrafish to study neuronal connectivity as an endpoint of developmental neurotoxicity. Neurotoxicology. PMID 29704525 DOI: 10.1016/j.neuro.2018.04.016  0.48
2018 Berg EL, Copping NA, Rivera JK, Pride MC, Careaga M, Bauman MD, Berman RF, Lein PJ, Harony-Nicolas H, Buxbaum JD, Ellegood J, Lerch JP, Wöhr M, Silverman JL. Developmental social communication deficits in the Shank3 rat model of phelan-mcdermid syndrome and autism spectrum disorder. Autism Research : Official Journal of the International Society For Autism Research. PMID 29377611 DOI: 10.1002/aur.1925  0.4
2017 Sethi S, Keil KP, Chen H, Hayakawa K, Li X, Lin Y, Lehmler HJ, Puschner B, Lein PJ. Detection of 3,3'-Dichlorobiphenyl in Human Maternal Plasma and Its Effects on Axonal and Dendritic Growth in Primary Rat Neurons. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 28510766 DOI: 10.1093/toxsci/kfx100  0.4
2017 Kania-Korwel I, Lukasiewicz T, Barnhart CD, Stamou M, Chung H, Kelly KM, Bandiera S, Lein PJ, Lehmler HJ. Congener-Specific Disposition of Chiral Polychlorinated Biphenyls in Lactating Mice and Their Offspring: Implications for PCB Developmental Neurotoxicity. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 28431184 DOI: 10.1093/toxsci/kfx071  0.56
2017 Chen H, Judkins J, Thomas C, Wu M, Khoury L, Benjamin CG, Pacione D, Golfinos JG, Kumthekar P, Ghamsari F, Chen L, Lein P, Chetkovich DM, Snuderl M, Horbinski C. Mutant IDH1 and seizures in patients with glioma. Neurology. PMID 28404805 DOI: 10.1212/WNL.0000000000003911  0.48
2017 Sisó S, Hobson BA, Harvey DJ, Bruun DA, Rowland DJ, Garbow JR, Lein PJ. Spatiotemporal Progression and Remission of Lesions in the Rat Brain Following Acute Intoxication with Diisopropylfluorophosphate. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 28329845 DOI: 10.1093/toxsci/kfx048  0.76
2017 Hobson BA, Sisó S, Rowland DJ, Harvey DJ, Bruun DA, Garbow JR, Lein PJ. Magnetic Resonance Imaging Reveals Progressive Brain Injury in Rats Acutely Intoxicated with Diisopropylfluorophosphate. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 28329842 DOI: 10.1093/toxsci/kfx049  0.76
2016 Chen H, Streifel KM, Singh V, Yang D, Mangini L, Wulff H, Lein PJ. BDE-47 and BDE-49 Inhibit Axonal Growth in Primary Rat Hippocampal Neuron-Glia Co-Cultures via Ryanodine Receptor-Dependent Mechanisms. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 28003438 DOI: 10.1093/toxsci/kfw259  0.36
2016 Flannery BM, Bruun DA, Rowland DJ, Banks CN, Austin AT, Kukis DL, Li Y, Ford BD, Tancredi DJ, Silverman JL, Cherry SR, Lein PJ. Persistent neuroinflammation and cognitive impairment in a rat model of acute diisopropylfluorophosphate intoxication. Journal of Neuroinflammation. 13: 267. PMID 27733171 DOI: 10.1186/s12974-016-0744-y  1
2016 Pessah IN, Rogawski MA, Tancredi DJ, Wulff H, Zolkowska D, Bruun DA, Hammock BD, Lein PJ. Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents. Annals of the New York Academy of Sciences. PMID 27467073 DOI: 10.1111/nyas.13137  1
2016 Bal-Price A, Lein PJ, Keil KP, Sethi S, Shafer T, Barenys M, Fritsche E, Sachana M, Meek ME. Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity. Neurotoxicology. PMID 27212452 DOI: 10.1016/j.neuro.2016.05.010  1
2016 Singh L, Pressly B, Mengeling BJ, Fettinger JC, Furlow JD, Lein PJ, Wulff H, Singh V. Chasing the Elusive Benzofuran Impurity of the THR Antagonist NH-3: Synthesis, Isotope Labeling and Biological Activity. The Journal of Organic Chemistry. PMID 26849160 DOI: 10.1021/acs.joc.5b02665  1
2016 Saldarriaga W, Lein P, González Teshima LY, Isaza C, Rosa L, Polyak A, Hagerman R, Girirajan S, Silva M, Tassone F. PHENOBARBITAL USE AND NEUROLOGICAL PROBLEMS IN FMR1 PREMUTATION CARRIERS. Neurotoxicology. PMID 26802682 DOI: 10.1016/j.neuro.2016.01.008  1
2016 Lee YS, Lewis JA, Ippolito DL, Hussainzada N, Lein PJ, Jackson DA, Stallings JD. Repeated exposure to neurotoxic levels of chlorpyrifos alters hippocampal expression of neurotrophins and neuropeptides. Toxicology. PMID 26775027 DOI: 10.1016/j.tox.2016.01.001  1
2015 Courter LA, Shaffo FC, Ghogha A, Parrish DJ, Lorentz CU, Habecker BA, Lein PJ. BMP7-Induced Dendritic Growth in Sympathetic Neurons Requires p75(NTR) Signaling. Developmental Neurobiology. PMID 26663679 DOI: 10.1002/dneu.22371  1
2015 Bui-Nguyen TM, Baer CE, Lewis JA, Yang D, Lein PJ, Jackson DA. Dichlorvos exposure results in large scale disruption of energy metabolism in the liver of the zebrafish, Danio rerio. Bmc Genomics. 16: 853. PMID 26499117 DOI: 10.1186/s12864-015-1941-2  1
2015 Stamou M, Uwimana E, Flannery BM, Kania-Korwel I, Lehmler HJ, Lein PJ. Subacute nicotine co-exposure has no effect on 2,2',3,5',6- pentachlorobiphenyl disposition but alters hepatic cytochrome P450 expression in the male rat. Toxicology. 338: 59-68. PMID 26463278 DOI: 10.1016/j.tox.2015.10.002  1
2015 Kania-Korwel I, Barnhart CD, Lein PJ, Lehmler HJ. Effect of Pregnancy on the Disposition of 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) Atropisomers and Their Hydroxylated Metabolites in Female Mice. Chemical Research in Toxicology. 28: 1774-83. PMID 26271003 DOI: 10.1021/acs.chemrestox.5b00241  1
2015 Chandrasekaran V, Lea C, Sosa JC, Higgins D, Lein PJ. Reactive oxygen species are involved in BMP-induced dendritic growth in cultured rat sympathetic neurons. Molecular and Cellular Neurosciences. 67: 116-125. PMID 26079955 DOI: 10.1016/j.mcn.2015.06.007  1
2015 Proskocil BJ, Bruun DA, Garg JA, Villagomez CC, Jacoby DB, Lein PJ, Fryer AD. Sensitization Can Influence Mechanisms of Organophosphorus Pesticide-Induced Airway Hyperreactivity. American Journal of Respiratory Cell and Molecular Biology. PMID 25897622 DOI: 10.1165/rcmb.2014-0444OC  1
2015 Barnhart CD, Yang D, Lein PJ. Using the Morris water maze to assess spatial learning and memory in weanling mice. Plos One. 10: e0124521. PMID 25886563 DOI: 10.1371/journal.pone.0124521  1
2015 Bruun DA, Cao Z, Inceoglu B, Vito ST, Austin AT, Hulsizer S, Hammock BD, Tancredi DJ, Rogawski MA, Pessah IN, Lein PJ. Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures. Neuropharmacology. 95: 332-42. PMID 25882826 DOI: 10.1016/j.neuropharm.2015.03.035  1
2015 Li Y, Lein PJ, Ford GD, Liu C, Stovall KC, White TE, Bruun DA, Tewolde T, Gates AS, Distel TJ, Surles-Zeigler MC, Ford BD. Neuregulin-1 inhibits neuroinflammatory responses in a rat model of organophosphate-nerve agent-induced delayed neuronal injury. Journal of Neuroinflammation. 12: 64. PMID 25880399 DOI: 10.1186/s12974-015-0283-y  1
2015 Harrill JA, Chen H, Streifel KM, Yang D, Mundy WR, Lein PJ. Ontogeny of biochemical, morphological and functional parameters of synaptogenesis in primary cultures of rat hippocampal and cortical neurons. Molecular Brain. 8: 10. PMID 25757474 DOI: 10.1186/s13041-015-0099-9  1
2015 Chapman CA, Chen H, Stamou M, Biener J, Biener MM, Lein PJ, Seker E. Nanoporous gold as a neural interface coating: effects of topography, surface chemistry, and feature size. Acs Applied Materials & Interfaces. 7: 7093-100. PMID 25706691 DOI: 10.1021/acsami.5b00410  1
2015 Bal-Price A, Crofton KM, Sachana M, Shafer TJ, Behl M, Forsby A, Hargreaves A, Landesmann B, Lein PJ, Louisse J, Monnet-Tschudi F, Paini A, Rolaki A, Schrattenholz A, Suñol C, et al. Putative adverse outcome pathways relevant to neurotoxicity. Critical Reviews in Toxicology. 45: 83-91. PMID 25605028 DOI: 10.3109/10408444.2014.981331  1
2015 Cao Z, Zou X, Cui Y, Hulsizer S, Lein PJ, Wulff H, Pessah IN. Rapid throughput analysis demonstrates that chemicals with distinct seizurogenic mechanisms differentially alter Ca2+ dynamics in networks formed by hippocampal neurons in culture. Molecular Pharmacology. 87: 595-605. PMID 25583085 DOI: 10.1124/mol.114.096701  1
2015 Grodzki AC, Poola B, Pasupuleti N, Nantz MH, Lein PJ, Gorin F. A novel carboline derivative inhibits nitric oxide formation in macrophages independent of effects on tumor necrosis factor α and interleukin-1β expression. The Journal of Pharmacology and Experimental Therapeutics. 352: 438-47. PMID 25538105 DOI: 10.1124/jpet.114.220186  1
2015 Singleton ST, Lein PJ, Dadson OA, McGarrigle BP, Farahat FM, Farahat T, Bonner MR, Fenske RA, Galvin K, Lasarev MR, Anger WK, Rohlman DS, Olson JR. Longitudinal assessment of occupational exposures to the organophosphorous insecticides chlorpyrifos and profenofos in Egyptian cotton field workers. International Journal of Hygiene and Environmental Health. 218: 203-11. PMID 25466362 DOI: 10.1016/j.ijheh.2014.10.005  1
2015 Flannery BM, Silverman JL, Bruun DA, Puhger KR, McCoy MR, Hammock BD, Crawley JN, Lein PJ. Behavioral assessment of NIH Swiss mice acutely intoxicated with tetramethylenedisulfotetramine. Neurotoxicology and Teratology. 47: 36-45. PMID 25446016 DOI: 10.1016/  1
2015 Wu X, Barnhart C, Lein PJ, Lehmler HJ. Hepatic metabolism affects the atropselective disposition of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) in mice. Environmental Science & Technology. 49: 616-25. PMID 25420130 DOI: 10.1021/es504766p  1
2015 Lein PJ. Overview of the Role of Environmental Factors in Neurodevelopmental Disorders Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders. 3-20. DOI: 10.1016/B978-0-12-800228-5.00001-7  1
2014 Levoe SN, Flannery BM, Brignolo L, Imai DM, Koehne A, Austin AT, Bruun DA, Tancredi DJ, Lein PJ. Factors influencing adverse skin responses in rats receiving repeated subcutaneous injections and potential impact on neurobehavior. Current Neurobiology. 5: 1-10. PMID 25705100  1
2014 Vito ST, Austin AT, Banks CN, Inceoglu B, Bruun DA, Zolkowska D, Tancredi DJ, Rogawski MA, Hammock BD, Lein PJ. Post-exposure administration of diazepam combined with soluble epoxide hydrolase inhibition stops seizures and modulates neuroinflammation in a murine model of acute TETS intoxication. Toxicology and Applied Pharmacology. 281: 185-94. PMID 25448683 DOI: 10.1016/j.taap.2014.10.001  1
2014 Haudenschild DR, Eldridge A, Lein PJ, Chromy BA. High abundant protein removal from rodent blood for biomarker discovery. Biochemical and Biophysical Research Communications. 455: 84-9. PMID 25445603 DOI: 10.1016/j.bbrc.2014.09.137  1
2014 Moore CE, Lein PJ, Puschner B. Microcystins alter chemotactic behavior in Caenorhabditis elegans by selectively targeting the AWA sensory neuron. Toxins. 6: 1813-36. PMID 24918360 DOI: 10.3390/toxins6061813  1
2014 Lesiak A, Zhu M, Chen H, Appleyard SM, Impey S, Lein PJ, Wayman GA. The environmental neurotoxicant PCB 95 promotes synaptogenesis via ryanodine receptor-dependent miR132 upregulation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 717-25. PMID 24431430 DOI: 10.1523/JNEUROSCI.2884-13.2014  1
2014 Yang D, Kania-Korwel I, Ghogha A, Chen H, Stamou M, Bose DD, Pessah IN, Lehmler HJ, Lein PJ. PCB 136 atropselectively alters morphometric and functional parameters of neuronal connectivity in cultured rat hippocampal neurons via ryanodine receptor-dependent mechanisms. Toxicological Sciences : An Official Journal of the Society of Toxicology. 138: 379-92. PMID 24385416 DOI: 10.1093/toxsci/kft334  1
2014 Singleton ST, Lein PJ, Farahat FM, Farahat T, Bonner MR, Knaak JB, Olson JR. Characterization of α-cypermethrin exposure in Egyptian agricultural workers. International Journal of Hygiene and Environmental Health. 217: 538-45. PMID 24269189 DOI: 10.1016/j.ijheh.2013.10.003  1
2014 Stamou M, Wu X, Kania-Korwel I, Lehmler HJ, Lein PJ. Cytochrome p450 mRNA expression in the rodent brain: species-, sex-, and region-dependent differences. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 239-44. PMID 24255117 DOI: 10.1124/dmd.113.054239  1
2013 Wu X, Kania-Korwel I, Chen H, Stamou M, Dammanahalli KJ, Duffel M, Lein PJ, Lehmler HJ. Metabolism of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) atropisomers in tissue slices from phenobarbital or dexamethasone-induced rats is sex-dependent. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 43: 933-47. PMID 23581876 DOI: 10.3109/00498254.2013.785626  1
2013 Dadson OA, Ellison CA, Singleton ST, Chi LH, McGarrigle BP, Lein PJ, Farahat FM, Farahat T, Olson JR. Metabolism of profenofos to 4-bromo-2-chlorophenol, a specific and sensitive exposure biomarker. Toxicology. 306: 35-9. PMID 23415833 DOI: 10.1016/j.tox.2013.01.023  1
2013 Proskocil BJ, Bruun DA, Jacoby DB, van Rooijen N, Lein PJ, Fryer AD. Macrophage TNF-α mediates parathion-induced airway hyperreactivity in guinea pigs. American Journal of Physiology. Lung Cellular and Molecular Physiology. 304: L519-29. PMID 23377347 DOI: 10.1152/ajplung.00381.2012  1
2013 Grodzki AC, Giulivi C, Lein PJ. Oxygen tension modulates differentiation and primary macrophage functions in the human monocytic THP-1 cell line. Plos One. 8: e54926. PMID 23355903 DOI: 10.1371/journal.pone.0054926  1
2013 Stamou M, Streifel KM, Goines PE, Lein PJ. Neuronal connectivity as a convergent target of gene × environment interactions that confer risk for Autism Spectrum Disorders. Neurotoxicology and Teratology. 36: 3-16. PMID 23269408 DOI: 10.1016/  1
2013 Mooney SM, Lein PJ, Miller MW. Fetal Alcohol Spectrum Disorder: Targeted Effects of Ethanol on Cell Proliferation and Survival Neural Circuit Development and Function in the Heathy and Diseased Brain. 521-537. DOI: 10.1016/B978-0-12-397267-5.00139-4  1
2012 Liu C, Li Y, Lein PJ, Ford BD. Spatiotemporal patterns of GFAP upregulation in rat brain following acute intoxication with diisopropylfluorophosphate (DFP). Current Neurobiology. 3: 90-97. PMID 24039349  1
2012 Ellison CA, Crane AL, Bonner MR, Knaak JB, Browne RW, Lein PJ, Olson JR. PON1 status does not influence cholinesterase activity in Egyptian agricultural workers exposed to chlorpyrifos. Toxicology and Applied Pharmacology. 265: 308-15. PMID 22975224 DOI: 10.1016/j.taap.2012.08.031  1
2012 Kania-Korwel I, Barnhart CD, Stamou M, Truong KM, El-Komy MH, Lein PJ, Veng-Pedersen P, Lehmler HJ. 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice. Environmental Science & Technology. 46: 11393-401. PMID 22974126 DOI: 10.1021/es302810t  1
2012 Bal-Price AK, Coecke S, Costa L, Crofton KM, Fritsche E, Goldberg A, Grandjean P, Lein PJ, Li A, Lucchini R, Mundy WR, Padilla S, Persico AM, Seiler AE, Kreysa J. Advancing the science of developmental neurotoxicity (DNT): testing for better safety evaluation. Altex. 29: 202-15. PMID 22892558  1
2012 Cao Z, Hammock BD, McCoy M, Rogawski MA, Lein PJ, Pessah IN. Tetramethylenedisulfotetramine alters Ca²⁺ dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation. Toxicological Sciences : An Official Journal of the Society of Toxicology. 130: 362-72. PMID 22889812 DOI: 10.1093/toxsci/kfs244  1
2012 Lein PJ. Emerging concepts in neurotoxicology: models, mechanisms and modifying factors. Neurotoxicology. 33: 516-7. PMID 22694846 DOI: 10.1016/j.neuro.2012.04.010  1
2012 Li Y, Lein PJ, Liu C, Bruun DA, Giulivi C, Ford GD, Tewolde T, Ross-Inta C, Ford BD. Neuregulin-1 is neuroprotective in a rat model of organophosphate-induced delayed neuronal injury. Toxicology and Applied Pharmacology. 262: 194-204. PMID 22583949 DOI: 10.1016/j.taap.2012.05.001  1
2012 Wayman GA, Bose DD, Yang D, Lesiak A, Bruun D, Impey S, Ledoux V, Pessah IN, Lein PJ. PCB-95 modulates the calcium-dependent signaling pathway responsible for activity-dependent dendritic growth. Environmental Health Perspectives. 120: 1003-9. PMID 22534176 DOI: 10.1289/ehp.1104833  1
2012 Wayman GA, Yang D, Bose DD, Lesiak A, Ledoux V, Bruun D, Pessah IN, Lein PJ. PCB-95 promotes dendritic growth via ryanodine receptor-dependent mechanisms. Environmental Health Perspectives. 120: 997-1002. PMID 22534141 DOI: 10.1289/ehp.1104832  1
2012 Ghogha A, Bruun DA, Lein PJ. Inducing dendritic growth in cultured sympathetic neurons. Journal of Visualized Experiments : Jove. PMID 22473299 DOI: 10.3791/3546  1
2012 Ellison CA, Abou El-Ella SS, Tawfik M, Lein PJ, Olson JR. Allele and genotype frequencies of CYP2B6 and CYP2C19 polymorphisms in Egyptian agricultural workers. Journal of Toxicology and Environmental Health. Part A. 75: 232-41. PMID 22352331 DOI: 10.1080/15287394.2012.641201  1
2012 Banks CN, Lein PJ. A review of experimental evidence linking neurotoxic organophosphorus compounds and inflammation. Neurotoxicology. 33: 575-84. PMID 22342984 DOI: 10.1016/j.neuro.2012.02.002  1
2012 Zolkowska D, Banks CN, Dhir A, Inceoglu B, Sanborn JR, McCoy MR, Bruun DA, Hammock BD, Lein PJ, Rogawski MA. Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine. The Journal of Pharmacology and Experimental Therapeutics. 341: 435-46. PMID 22328574 DOI: 10.1124/jpet.111.190579  1
2012 Lein PJ, Bonner MR, Farahat FM, Olson JR, Rohlman DS, Fenske RA, Lattal KM, Lasarev MR, Galvin K, Farahat TM, Anger WK. Experimental strategy for translational studies of organophosphorus pesticide neurotoxicity based on real-world occupational exposures to chlorpyrifos. Neurotoxicology. 33: 660-8. PMID 22240005 DOI: 10.1016/j.neuro.2011.12.017  1
2012 van Thriel C, Westerink RH, Beste C, Bale AS, Lein PJ, Leist M. Translating neurobehavioural endpoints of developmental neurotoxicity tests into in vitro assays and readouts. Neurotoxicology. 33: 911-24. PMID 22008243 DOI: 10.1016/j.neuro.2011.10.002  1
2012 Harry GJ, Lein PJ. Developmental Neurotoxicity of Dioxins Dioxins and Health: Including Other Persistent Organic Pollutants and Endocrine Disruptors: Third Edition. 193-227. DOI: 10.1002/9781118184141.ch7  1
2011 Grodzki AC, Ghogha A, Mangini L, Fryer AD, Lein PJ. IFNγ Increases M2 Muscarinic Receptor Expression in Cultured Sympathetic Neurons. Current Neurobiology. 2: 23-29. PMID 23226931  1
2011 Lein PJ, Barnhart CD, Pessah IN. Acute hippocampal slice preparation and hippocampal slice cultures. Methods in Molecular Biology (Clifton, N.J.). 758: 115-34. PMID 21815062 DOI: 10.1007/978-1-61779-170-3_8  1
2011 Garred MM, Wang MM, Guo X, Harrington CA, Lein PJ. Transcriptional responses of cultured rat sympathetic neurons during BMP-7-induced dendritic growth. Plos One. 6: e21754. PMID 21765909 DOI: 10.1371/journal.pone.0021754  1
2011 Ellison CA, Smith JN, Lein PJ, Olson JR. Pharmacokinetics and pharmacodynamics of chlorpyrifos in adult male Long-Evans rats following repeated subcutaneous exposure to chlorpyrifos. Toxicology. 287: 137-44. PMID 21708215 DOI: 10.1016/j.tox.2011.06.010  1
2011 Li Y, Lein PJ, Liu C, Bruun DA, Tewolde T, Ford G, Ford BD. Spatiotemporal pattern of neuronal injury induced by DFP in rats: a model for delayed neuronal cell death following acute OP intoxication. Toxicology and Applied Pharmacology. 253: 261-9. PMID 21513723 DOI: 10.1016/j.taap.2011.03.026  1
2011 Yang D, Lauridsen H, Buels K, Chi LH, La Du J, Bruun DA, Olson JR, Tanguay RL, Lein PJ. Chlorpyrifos-oxon disrupts zebrafish axonal growth and motor behavior. Toxicological Sciences : An Official Journal of the Society of Toxicology. 121: 146-59. PMID 21346248 DOI: 10.1093/toxsci/kfr028  1
2011 Crofton KM, Mundy WR, Lein PJ, Bal-Price A, Coecke S, Seiler AE, Knaut H, Buzanska L, Goldberg A. Developmental neurotoxicity testing: recommendations for developing alternative methods for the screening and prioritization of chemicals. Altex. 28: 9-15. PMID 21311847  1
2011 Farahat FM, Ellison CA, Bonner MR, McGarrigle BP, Crane AL, Fenske RA, Lasarev MR, Rohlman DS, Anger WK, Lein PJ, Olson JR. Biomarkers of chlorpyrifos exposure and effect in Egyptian cotton field workers. Environmental Health Perspectives. 119: 801-6. PMID 21224175 DOI: 10.1289/ehp.1002873  1
2011 Rohlman DS, Anger WK, Lein PJ. Correlating neurobehavioral performance with biomarkers of organophosphorous pesticide exposure. Neurotoxicology. 32: 268-76. PMID 21182866 DOI: 10.1016/j.neuro.2010.12.008  1
2011 Abdu E, Bruun DA, Yang D, Yang J, Inceoglu B, Hammock BD, Alkayed NJ, Lein PJ. Epoxyeicosatrienoic acids enhance axonal growth in primary sensory and cortical neuronal cell cultures. Journal of Neurochemistry. 117: 632-42. PMID 21155804 DOI: 10.1111/j.1471-4159.2010.07139.x  1
2011 Kim KH, Bose DD, Ghogha A, Riehl J, Zhang R, Barnhart CD, Lein PJ, Pessah IN. Para- and ortho-substitutions are key determinants of polybrominated diphenyl ether activity toward ryanodine receptors and neurotoxicity. Environmental Health Perspectives. 119: 519-26. PMID 21106467 DOI: 10.1289/ehp.1002728  1
2010 Yang D, Bruun D, Andres DA, Lein PJ. Method for Shipping Live Cultures of Dissociated Rat Hippocampal Neurons. Current Neurobiology. 1: 95-98. PMID 24052689  1
2010 Yang D, Lein PJ. Polychlorinated biphenyls increase apoptosis in the developing rat brain. Current Neurobiology. 1: 70-76. PMID 24052688  1
2010 Proskocil BJ, Bruun DA, Thompson CM, Fryer AD, Lein PJ. Organophosphorus pesticides decrease M2 muscarinic receptor function in guinea pig airway nerves via indirect mechanisms. Plos One. 5: e10562. PMID 20479945 DOI: 10.1371/journal.pone.0010562  1
2010 Farahat FM, Fenske RA, Olson JR, Galvin K, Bonner MR, Rohlman DS, Farahat TM, Lein PJ, Anger WK. Chlorpyrifos exposures in Egyptian cotton field workers. Neurotoxicology. 31: 297-304. PMID 20193710 DOI: 10.1016/j.neuro.2010.02.005  1
2010 Pessah IN, Cherednichenko G, Lein PJ. Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity. Pharmacology & Therapeutics. 125: 260-85. PMID 19931307 DOI: 10.1016/j.pharmthera.2009.10.009  1
2010 Lein PJ, Fryer AD, Higgins D. Cell Culture: Autonomic and Enteric Neurons Encyclopedia of Neuroscience. 625-632. DOI: 10.1016/B978-008045046-9.00626-4  1
2010 Lein PJ, Kim KH, Berman RF, Pessah IN. Exposure of the developing brain to polychlorinated biphenyls influences the susceptibility of the adult brain to stress Developmental Neurotoxicology Research: Principles, Models, Techniques, Strategies, and Mechanisms. 211-229. DOI: 10.1002/9780470917060.ch12  1
2009 Halladay AK, Amaral D, Aschner M, Bolivar VJ, Bowman A, DiCicco-Bloom E, Hyman SL, Keller F, Lein P, Pessah I, Restifo L, Threadgill DW. Animal models of autism spectrum disorders: information for neurotoxicologists. Neurotoxicology. 30: 811-21. PMID 19596370 DOI: 10.1016/j.neuro.2009.07.002  1
2009 Yang D, Kim KH, Phimister A, Bachstetter AD, Ward TR, Stackman RW, Mervis RF, Wisniewski AB, Klein SL, Kodavanti PR, Anderson KA, Wayman G, Pessah IN, Lein PJ. Developmental exposure to polychlorinated biphenyls interferes with experience-dependent dendritic plasticity and ryanodine receptor expression in weanling rats. Environmental Health Perspectives. 117: 426-35. PMID 19337518 DOI: 10.1289/ehp.11771  1
2009 Kim WY, Gonsiorek EA, Barnhart C, Davare MA, Engebose AJ, Lauridsen H, Bruun D, Lesiak A, Wayman G, Bucelli R, Higgins D, Lein PJ. Statins decrease dendritic arborization in rat sympathetic neurons by blocking RhoA activation. Journal of Neurochemistry. 108: 1057-71. PMID 19209406 DOI: 10.1111/j.1471-4159.2008.05854.x  1
2008 Andres DA, Shi GX, Bruun D, Barnhart C, Lein PJ. Rit signaling contributes to interferon-gamma-induced dendritic retraction via p38 mitogen-activated protein kinase activation. Journal of Neurochemistry. 107: 1436-47. PMID 18957053 DOI: 10.1111/j.1471-4159.2008.05708.x  1
2008 Dziennis S, Yang D, Cheng J, Anderson KA, Alkayed NJ, Hurn PD, Lein PJ. Developmental exposure to polychlorinated biphenyls influences stroke outcome in adult rats. Environmental Health Perspectives. 116: 474-80. PMID 18414629 DOI: 10.1289/ehp.10828  1
2008 Boswell BA, Lein PJ, Musil LS. Cross-talk between fibroblast growth factor and bone morphogenetic proteins regulates gap junction-mediated intercellular communication in lens cells. Molecular Biology of the Cell. 19: 2631-41. PMID 18400943 DOI: 10.1091/mbc.E08-02-0124  1
2008 Pessah IN, Seegal RF, Lein PJ, LaSalle J, Yee BK, Van De Water J, Berman RF. Immunologic and neurodevelopmental susceptibilities of autism. Neurotoxicology. 29: 532-45. PMID 18394707 DOI: 10.1016/j.neuro.2008.02.006  1
2008 Proskocil BJ, Bruun DA, Lorton JK, Blensly KC, Jacoby DB, Lein PJ, Fryer AD. Antigen sensitization influences organophosphorus pesticide-induced airway hyperreactivity. Environmental Health Perspectives. 116: 381-8. PMID 18335107 DOI: 10.1289/ehp.10694  1
2008 Bucelli RC, Gonsiorek EA, Kim WY, Bruun D, Rabin RA, Higgins D, Lein PJ. Statins decrease expression of the proinflammatory neuropeptides calcitonin gene-related peptide and substance P in sensory neurons. The Journal of Pharmacology and Experimental Therapeutics. 324: 1172-80. PMID 18079356 DOI: 10.1124/jpet.107.132795  1
2008 Yang D, Howard A, Bruun D, Ajua-Alemanj M, Pickart C, Lein PJ. Chlorpyrifos and chlorpyrifos-oxon inhibit axonal growth by interfering with the morphogenic activity of acetylcholinesterase. Toxicology and Applied Pharmacology. 228: 32-41. PMID 18076960 DOI: 10.1016/j.taap.2007.11.005  1
2007 Coecke S, Goldberg AM, Allen S, Buzanska L, Calamandrei G, Crofton K, Hareng L, Hartung T, Knaut H, Honegger P, Jacobs M, Lein P, Li A, Mundy W, Owen D, et al. Workgroup report: incorporating in vitro alternative methods for developmental neurotoxicity into international hazard and risk assessment strategies. Environmental Health Perspectives. 115: 924-31. PMID 17589601 DOI: 10.1289/ehp.9427  1
2007 Lein P, Locke P, Goldberg A. Meeting report: alternatives for developmental neurotoxicity testing. Environmental Health Perspectives. 115: 764-8. PMID 17520065 DOI: 10.1289/ehp.9841  1
2007 Lein PJ, Guo X, Shi GX, Moholt-Siebert M, Bruun D, Andres DA. The novel GTPase Rit differentially regulates axonal and dendritic growth. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 4725-36. PMID 17460085 DOI: 10.1523/JNEUROSCI.5633-06.2007  1
2007 Lein PJ, Yang D, Bachstetter AD, Tilson HA, Harry GJ, Mervis RF, Kodavanti PR. Ontogenetic alterations in molecular and structural correlates of dendritic growth after developmental exposure to polychlorinated biphenyls. Environmental Health Perspectives. 115: 556-63. PMID 17450224 DOI: 10.1289/ehp.9773  1
2006 Pin S, Chen H, Lein PJ, Wang MM. Nucleic acid binding agents exert local toxic effects on neurites via a non-nuclear mechanism. Journal of Neurochemistry. 96: 1253-66. PMID 16441515 DOI: 10.1111/j.1471-4159.2006.03653.x  1
2006 Jett DA, Lein PJ. Noncholinesterase mechanisms of central and peripheral neurotoxicity: Muscarinic receptors and other targets Toxicology of Organophosphate & Carbamate Compounds. 233-245. DOI: 10.1016/B978-012088523-7/50018-1  1
2005 Lein P, Silbergeld E, Locke P, Goldberg AM. In vitro and other alternative approaches to developmental neurotoxicity testing (DNT). Environmental Toxicology and Pharmacology. 19: 735-44. PMID 21783550 DOI: 10.1016/j.etap.2004.12.035  1
2005 Howard AS, Bucelli R, Jett DA, Bruun D, Yang D, Lein PJ. Chlorpyrifos exerts opposing effects on axonal and dendritic growth in primary neuronal cultures. Toxicology and Applied Pharmacology. 207: 112-24. PMID 16102564 DOI: 10.1016/j.taap.2004.12.008  1
2005 Lein PJ, Fryer AD. Organophosphorus insecticides induce airway hyperreactivity by decreasing neuronal M2 muscarinic receptor function independent of acetylcholinesterase inhibition. Toxicological Sciences : An Official Journal of the Society of Toxicology. 83: 166-76. PMID 15470232 DOI: 10.1093/toxsci/kfi001  1
2004 Shen W, Finnegan S, Lein P, Sullivan S, Slaughter M, Higgins D. Bone morphogenetic proteins regulate ionotropic glutamate receptors in human retina. The European Journal of Neuroscience. 20: 2031-7. PMID 15450082 DOI: 10.1111/j.1460-9568.2004.03681.x  1
2004 Kim IJ, Drahushuk KM, Kim WY, Gonsiorek EA, Lein P, Andres DA, Higgins D. Extracellular signal-regulated kinases regulate dendritic growth in rat sympathetic neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 3304-12. PMID 15056710 DOI: 10.1523/JNEUROSCI.3286-03.2004  1
2004 Fryer AD, Lein PJ, Howard AS, Yost BL, Beckles RA, Jett DA. Mechanisms of organophosphate insecticide-induced airway hyperreactivity. American Journal of Physiology. Lung Cellular and Molecular Physiology. 286: L963-9. PMID 14704222 DOI: 10.1152/ajplung.00343.2003  1
2003 Chen HL, Lein PJ, Wang JY, Gash D, Hoffer BJ, Chiang YH. Expression of bone morphogenetic proteins in the brain during normal aging and in 6-hydroxydopamine-lesioned animals. Brain Research. 994: 81-90. PMID 14642451 DOI: 10.1016/j.brainres.2003.09.020  1
2003 Howard AS, Fitzpatrick R, Pessah I, Kostyniak P, Lein PJ. Polychlorinated biphenyls induce caspase-dependent cell death in cultured embryonic rat hippocampal but not cortical neurons via activation of the ryanodine receptor. Toxicology and Applied Pharmacology. 190: 72-86. PMID 12831785 DOI: 10.1016/S0041-008X(03)00156-X  1
2003 Chang CF, Lin SZ, Chiang YH, Morales M, Chou J, Lein P, Chen HL, Hoffer BJ, Wang Y. Intravenous administration of bone morphogenetic protein-7 after ischemia improves motor function in stroke rats. Stroke; a Journal of Cerebral Circulation. 34: 558-64. PMID 12574575 DOI: 10.1161/01.STR.0000051507.64423.00  1
2002 Lein PJ, Beck HN, Chandrasekaran V, Gallagher PJ, Chen HL, Lin Y, Guo X, Kaplan PL, Tiedge H, Higgins D. Glia induce dendritic growth in cultured sympathetic neurons by modulating the balance between bone morphogenetic proteins (BMPs) and BMP antagonists. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 10377-87. PMID 12451137  1
2002 Roth JA, Horbinski C, Higgins D, Lein P, Garrick MD. Mechanisms of manganese-induced rat pheochromocytoma (PC12) cell death and cell differentiation. Neurotoxicology. 23: 147-57. PMID 12224755 DOI: 10.1016/S0161-813X(01)00077-8  1
2002 Schuh RA, Lein PJ, Beckles RA, Jett DA. Noncholinesterase mechanisms of chlorpyrifos neurotoxicity: altered phosphorylation of Ca2+/cAMP response element binding protein in cultured neurons. Toxicology and Applied Pharmacology. 182: 176-85. PMID 12140181 DOI: 10.1006/taap.2002.9445  1
2002 Kim IJ, Beck HN, Lein PJ, Higgins D. Interferon gamma induces retrograde dendritic retraction and inhibits synapse formation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 4530-9. PMID 12040060  1
2001 Dattatreyamurty B, Roux E, Horbinski C, Kaplan PL, Robak LA, Beck HN, Lein P, Higgins D, Chandrasekaran V. Cerebrospinal fluid contains biologically active bone morphogenetic protein-7. Experimental Neurology. 172: 273-81. PMID 11716552 DOI: 10.1006/exnr.2001.7728  1
2001 Beck HN, Drahushuk K, Jacoby DB, Higgins D, Lein PJ. Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons. Bmc Neuroscience. 2: 12. PMID 11580864 DOI: 10.1186/1471-2202-2-12  1
2001 Guo X, Lin Y, Horbinski C, Drahushuk KM, Kim IJ, Kaplan PL, Lein P, Wang T, Higgins D. Dendritic growth induced by BMP-7 requires Smad1 and proteasome activity. Journal of Neurobiology. 48: 120-30. PMID 11438941 DOI: 10.1002/neu.1046  1
2000 Lein P, Gallagher PJ, Amodeo J, Howie H, Roth JA. Manganese induces neurite outgrowth in PC12 cells via upregulation of alpha(v) integrins. Brain Research. 885: 220-30. PMID 11102576 DOI: 10.1016/S0006-8993(00)02943-7  1
1999 Guo X, Chandrasekaran V, Lein P, Kaplan PL, Higgins D. Leukemia inhibitory factor and ciliary neurotrophic factor cause dendritic retraction in cultured rat sympathetic neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 2113-21. PMID 10066264  1
1998 Gadient RA, Lein P, Higgins D, Patterson PH. Effect of leukemia inhibitory factor (LIF) on the morphology and survival of cultured hippocampal neurons and glial cells. Brain Research. 798: 140-6. PMID 9666105 DOI: 10.1016/S0006-8993(98)00236-4  1
1997 Guo X, Metzler-Northrup J, Lein P, Rueger D, Higgins D. Leukemia inhibitory factor and ciliary neurotrophic factor regulate dendritic growth in cultures of rat sympathetic neurons. Brain Research. Developmental Brain Research. 104: 101-10. PMID 9466712 DOI: 10.1016/S0165-3806(97)00142-9  1
1997 Higgins D, Burack M, Lein P, Banker G. Mechanisms of neuronal polarity. Current Opinion in Neurobiology. 7: 599-604. PMID 9384542 DOI: 10.1016/S0959-4388(97)80078-5  1
1996 Lein P, Higgins D. Antibodies to β1 integrins inhibit dendritic growth in rat sympathetic neurons. Biomedical Research (Aligarh, India). 7: 101-111. PMID 29238133  1
1996 Lein P, Guo X, Hedges AM, Rueger D, Johnson M, Higgins D. The effects of extracellular matrix and osteogenic protein-1 on the morphological differentiation of rat sympathetic neurons. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 14: 203-15. PMID 8842799 DOI: 10.1016/0736-5748(96)00008-1  1
1995 Lein P, Johnson M, Guo X, Rueger D, Higgins D. Osteogenic protein-1 induces dendritic growth in rat sympathetic neurons. Neuron. 15: 597-605. PMID 7546739 DOI: 10.1016/0896-6273(95)90148-5  1
1992 Lein PJ, Banker GA, Higgins D. Laminin selectively enhances axonal growth and accelerates the development of polarity by hippocampal neurons in culture. Brain Research. Developmental Brain Research. 69: 191-7. PMID 1424096 DOI: 10.1016/0165-3806(92)90159-T  1
1991 Lein PJ, Higgins D, Turner DC, Flier LA, Terranova VP. The NC1 domain of type IV collagen promotes axonal growth in sympathetic neurons through interaction with the alpha 1 beta 1 integrin. The Journal of Cell Biology. 113: 417-28. PMID 2010469  1
1991 Lein PJ, Higgins D. Protein synthesis is required for the initiation of dendritic growth in embryonic rat sympathetic neurons in vitro. Brain Research. Developmental Brain Research. 60: 187-96. PMID 1716531 DOI: 10.1016/0165-3806(91)90047-M  1
1990 Bruckenstein DA, Lein PJ, Higgins D, Fremeau RT. Distinct spatial localization of specific mRNAs in cultured sympathetic neurons. Neuron. 5: 809-19. PMID 2148487 DOI: 10.1016/0896-6273(90)90340-L  1
1989 Lein PJ, Higgins D. Laminin and a basement membrane extract have different effects on axonal and dendritic outgrowth from embryonic rat sympathetic neurons in vitro. Developmental Biology. 136: 330-45. PMID 2479584 DOI: 10.1016/0012-1606(89)90260-1  1
1988 Kung MP, Nickerson PA, Sansone FM, Olson JR, Kostyniak PJ, Adolf MA, Lein PJ, Roth JA. Effect of short-term exposure to hexachlorophene on rat brain cell specific marker enzymes. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology. 11: 519-27. PMID 2906023 DOI: 10.1016/0272-0590(88)90116-9  1
1988 Kung MP, Nickerson P, Sansone FM, Olson JR, Kostyniak PJ, Adolf MA, Lein PJ, Roth JA. Effect of short-term exposure to hexachlorophene on rat brain marker enzymes Toxicological Sciences. 11: 519-527. DOI: 10.1093/toxsci/11.1.519  1
1987 Pancorbo OC, Lein PJ, Blevins RD. Mutagenic activity of surface waters adjacent to a nuclear fuel processing facility. Archives of Environmental Contamination and Toxicology. 16: 531-7. PMID 3632040 DOI: 10.1007/BF01055809  1
Low-probability matches
2019 Hennebelle M, Morgan RK, Sethi S, Zhang Z, Chen H, Grodzki AC, Lein PJ, Taha AY. Linoleic acid-derived metabolites constitute the majority of oxylipins in the rat pup brain and stimulate axonal growth in primary rat cortical neuron-glia co-cultures in a sex-dependent manner. Journal of Neurochemistry. PMID 31283837 DOI: 10.1111/jnc.14818  0.24
2019 Stamou M, Lein PJ. Commentary: Fc Gamma Receptors are Expressed in the Developing Rat Brain and Activate Downstream Signaling Molecules upon Cross-Linking with Immune Complex. Journal of Neurology & Neuromedicine. 4: 26-29. PMID 31131371 DOI: 10.29245/2572.942X/2019/1.1243  0.24
2018 Keil KP, Miller GW, Chen H, Sethi S, Schmuck MR, Dhakal K, Kim JW, Lein PJ. PCB 95 promotes dendritic growth in primary rat hippocampal neurons via mTOR-dependent mechanisms. Archives of Toxicology. PMID 30132043 DOI: 10.1007/s00204-018-2285-x  0.24
2018 Shaffo FC, Grodzki AC, Schelegle ES, Lein PJ. The Organophosphorus Pesticide Chlorpyrifos Induces Sex-Specific Airway Hyperreactivity in Adult Rats. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 29939342 DOI: 10.1093/toxsci/kfy158  0.24
2018 Stamou M, Grodzki AC, van Oostrum M, Wollscheid B, Lein PJ. Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex. Journal of Neuroinflammation. 15: 7. PMID 29306331 DOI: 10.1186/s12974-017-1050-z  0.24
2017 Keil KP, Sethi S, Wilson MD, Chen H, Lein PJ. In vivo and in vitro sex differences in the dendritic morphology of developing murine hippocampal and cortical neurons. Scientific Reports. 7: 8486. PMID 28814778 DOI: 10.1038/s41598-017-08459-z  0.24
2017 Mengeling BJ, Wei Y, Dobrawa LN, Streekstra M, Louisse J, Singh V, Singh L, Lein PJ, Wulff H, Murk AJ, Furlow JD. A multi-tiered, in vivo, quantitative assay suite for environmental disruptors of thyroid hormone signaling. Aquatic Toxicology (Amsterdam, Netherlands). 190: 1-10. PMID 28662416 DOI: 10.1016/j.aquatox.2017.06.019  0.24
2017 Chapman CAR, Wang L, Chen H, Garrison J, Lein PJ, Seker E. Nanoporous Gold Biointerfaces: Modifying Nanostructure to Control Neural Cell Coverage and Enhance Electrophysiological Recording Performance. Advanced Functional Materials. 27. PMID 28626362 DOI: 10.1002/adfm.201604631  0.24
2017 Chapman CA, Zhu X, Chen H, Yanik AA, Lein PJ, Seker E. Nanostructure Introduces Artifacts in Quantitative Immunofluorescence by Influencing Fluorophore Intensity. Scientific Reports. 7: 427. PMID 28348397 DOI: 10.1038/s41598-017-00447-7  0.24
2016 Chapman CA, Chen H, Stamou M, Lein PJ, Seker E. Mechanisms of Reduced Astrocyte Surface Coverage in Cortical Neuron-Glia Co-cultures on Nanoporous Gold Surfaces. Cellular and Molecular Bioengineering. 9: 433-442. PMID 27795742 DOI: 10.1007/s12195-016-0449-4  0.24
2018 Keil KP, Sethi S, Lein PJ. Sex-dependent effects of 2,2',3,5',6-pentachlorobiphenyl (PCB 95) on dendritic arborization of primary mouse neurons. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 30395321 DOI: 10.1093/toxsci/kfy277  0.2
2018 Sethi S, Keil KP, Lein PJ. 3,3'-Dichlorobiphenyl (PCB 11) promotes dendritic arborization in primary rat cortical neurons via a CREB-dependent mechanism. Archives of Toxicology. PMID 30225637 DOI: 10.1007/s00204-018-2307-8  0.2
2018 Hampe AE, Li Z, Sethi S, Lein PJ, Seker E. A Microfluidic Platform to Study Astrocyte Adhesion on Nanoporous Gold Thin Films. Nanomaterials (Basel, Switzerland). 8. PMID 29933551 DOI: 10.3390/nano8070452  0.2
2017 Sethi S, Keil KP, Lein PJ. Species and Sex Differences in the Morphogenic Response of Primary Rodent Neurons to 3,3'-Dichlorobiphenyl (PCB 11). Toxics. 6. PMID 29295518 DOI: 10.3390/toxics6010004  0.2
2017 Wilson MD, Sethi S, Lein PJ, Keil KP. Valid Statistical Approaches for Analyzing Sholl Data: Mixed Effects versus Simple Linear Models. Journal of Neuroscience Methods. PMID 28104486 DOI: 10.1016/j.jneumeth.2017.01.003  0.2
2016 Keil KP, Lein PJ. DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? Environmental Epigenetics. 2. PMID 27158529 DOI: 10.1093/eep/dvv012  0.2
2018 Fritsche E, Grandjean P, Crofton KM, Aschner M, Goldberg A, Heinonen T, Hessel EVS, Hogberg H, Bennekou SH, Lein PJ, Leist M, Mundy WR, Paparella M, Piersma AH, Sachana M, et al. Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes. Toxicology and Applied Pharmacology. PMID 29447839 DOI: 10.1016/j.taap.2018.02.004  0.16
2017 van Thriel C, Levin E, Lein P, Costa LG, Westerink RH. Neural mechanisms of functional impairment across the lifespan: The 15th Biennial Meeting of the International Neurotoxicology Association and 39th Annual Meeting of the Neurobehavioral Teratology Society. Neurotoxicology. 59: 131-132. PMID 28347437 DOI: 10.1016/j.neuro.2017.03.003  0.12
2019 Walter KM, Dach K, Hayakawa K, Giersiefer S, Heuer H, Lein PJ, Fritsche E. Ontogenetic expression of thyroid hormone signaling genes: An in vitro and in vivo species comparison. Plos One. 14: e0221230. PMID 31513589 DOI: 10.1371/journal.pone.0221230  0.08
2019 Walter KM, Miller GW, Chen X, Harvey DJ, Puschner B, Lein PJ. Changes in Thyroid Hormone Activity Disrupt Photomotor Behavior of Larval Zebrafish. Neurotoxicology. PMID 31121238 DOI: 10.1016/j.neuro.2019.05.008  0.08
2018 Walter KM, Miller GW, Chen X, Yaghoobi B, Puschner B, Lein PJ. Effects of Thyroid Hormone Disruption on the Ontogenetic Expression of Thyroid Hormone Signaling Genes in Developing Zebrafish (Danio rerio). General and Comparative Endocrinology. PMID 30448381 DOI: 10.1016/j.ygcen.2018.11.007  0.08
2018 Frank DF, Brander SM, Hasenbein S, Harvey DJ, Lein PJ, Geist J, Connon RE. Developmental exposure to environmentally relevant concentrations of bifenthrin alters transcription of mTOR and ryanodine receptor-dependent signaling molecules and impairs predator avoidance behavior across early life stages in inland silversides (Menidia beryllina). Aquatic Toxicology (Amsterdam, Netherlands). 206: 1-13. PMID 30414561 DOI: 10.1016/j.aquatox.2018.10.014  0.08
2018 Saldarriaga W, Salcedo-Arellano MJ, Rodriguez-Guerrero T, Ríos M, Fandiño-Losada A, Ramirez-Cheyne J, Lein PJ, Tassone F, Hagerman RJ. Increased Severity of Fragile X Spectrum Disorders in the Agricultural Community of Ricaurte, Colombia. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. PMID 30385191 DOI: 10.1016/j.ijdevneu.2018.10.002  0.08
2018 Dach K, Yaghoobi B, Schmuck MR, Carty DR, Morales KM, Lein PJ. Teratological and behavioral screening of the National Toxicology Program 91-compound library in zebrafish (Danio rerio). Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 30364989 DOI: 10.1093/toxsci/kfy266  0.08
2018 Frank DF, Miller GW, Harvey DJ, Brander SM, Geist J, Connon RE, Lein PJ. Bifenthrin causes transcriptomic alterations in mTOR and ryanodine receptor-dependent signaling and delayed hyperactivity in developing zebrafish (Danio rerio). Aquatic Toxicology (Amsterdam, Netherlands). 200: 50-61. PMID 29727771 DOI: 10.1016/j.aquatox.2018.04.003  0.08
2018 Chen X, Walter KM, Miller GW, Lein PJ, Puschner B. Simultaneous quantification of T4, T3, rT3, 3,5-T2 and 3,3'-T2 in larval zebrafish (Danio rerio) as a model to study exposure to polychlorinated biphenyls. Biomedical Chromatography : Bmc. PMID 29314156 DOI: 10.1002/bmc.4185  0.08
2017 Frank DF, Miller GW, Connon RE, Geist J, Lein PJ. Transcriptomic profiling of mTOR and ryanodine receptor signaling molecules in developing zebrafish in the absence and presence of PCB 95. Peerj. 5: e4106. PMID 29201571 DOI: 10.7717/peerj.4106  0.08
2017 Hobson BA, Rowland DJ, Supasai S, Harvey DJ, Lein PJ, Garbow JR. A magnetic resonance imaging study of early brain injury in a rat model of acute DFP intoxication. Neurotoxicology. PMID 29183789 DOI: 10.1016/j.neuro.2017.11.009  0.08
2016 Aschner M, Ceccatelli S, Daneshian M, Fritsche E, Hasiwa N, Hartung T, Hogberg HT, Leist M, Li A, Mundi WR, Padilla S, Piersma AH, Bal-Price A, Seiler A, Westerink R, ... ... Lein P, et al. Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use. Altex. PMID 27452664 DOI: 10.14573/altex.1604201  0.04
2018 González EA, Carty DR, Tran FD, Cole AM, Lein PJ. Developmental Exposure to Silver Nanoparticles at Environmentally Relevant Concentrations Alters Swimming Behavior in Zebrafish (Danio rerio). Environmental Toxicology and Chemistry. PMID 30242895 DOI: 10.1002/etc.4275  0.01
2017 Dach K, Bendt F, Huebenthal U, Giersiefer S, Lein PJ, Heuer H, Fritsche E. BDE-99 impairs differentiation of human and mouse NPCs into the oligodendroglial lineage by species-specific modes of action. Scientific Reports. 7: 44861. PMID 28317842 DOI: 10.1038/srep44861  0.01
2016 Voorhees JR, Rohlman DS, Lein PJ, Pieper AA. Neurotoxicity in Preclinical Models of Occupational Exposure to Organophosphorus Compounds. Frontiers in Neuroscience. 10: 590. PMID 28149268 DOI: 10.3389/fnins.2016.00590  0.01
2016 Dunaway K, Goorha S, Matelski L, Urraca N, Lein PJ, Korf I, Reiter LT, LaSalle JM. Dental Pulp Stem Cells Model Early Life and Imprinted DNA Methylation Patterns. Stem Cells (Dayton, Ohio). PMID 28032673 DOI: 10.1002/stem.2563  0.01
1953 LEIN J, PUGLISI TA, LEIN PS. Unsaturated fatty acid metabolism in Neurospora. Archives of Biochemistry and Biophysics. 45: 434-42. PMID 13081151  0.01
1952 Lein J, Lein PS. Studies on a Suppressor of Non-Allelic Acetate-Requiring Mutants of Neurospora. Proceedings of the National Academy of Sciences of the United States of America. 38: 44-8. PMID 16589049  0.01
1951 LEIN J, APPLEBY DC, LEIN PS. Acetate formation in neurospora studied with biochemical mutants. Archives of Biochemistry and Biophysics. 34: 72-80. PMID 14904036  0.01
1950 LEIN J, LEIN PS. The production of acetate from fatty acids by Neurospora. Journal of Bacteriology. 60: 185-90. PMID 14774369  0.01
1949 LEIN J, LEIN PS. Stabilization of the thromboplastic lipid by hydroquinone. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 70: 446-8. PMID 18116445  0.01
1949 LEIN J, LEIN PS. Studies on a Neurospora mutant requiring unsaturated fatty acids for growth. Journal of Bacteriology. 58: 595-9. PMID 15393690  0.01
1948 LEIN J, LEIN PS. An altered prothrombin produced by dicumarol-treated rabbits. The American Journal of Physiology. 155: 394-401. PMID 18113179  0.01
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