Pamela J. Lein - Publications

Affiliations: 
University of California, Davis, Davis, CA 
Area:
developmental neurobiology, dendrites

137/271 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Karunungan K, Garza RH, Grodzki AC, Holt M, Lein PJ, Chandrasekaran V. Gamma secretase activity modulates BMP-7-induced dendritic growth in primary rat sympathetic neurons. Autonomic Neuroscience : Basic & Clinical. 247: 103085. PMID 37031474 DOI: 10.1016/j.autneu.2023.103085  0.382
2022 Yaghoobi B, Miller GW, Holland EB, Li X, Harvey D, Li S, Lehmler HJ, Pessah IN, Lein PJ. Ryanodine receptor-active non-dioxin-like polychlorinated biphenyls cause neurobehavioral deficits in larval zebrafish. Frontiers in Toxicology. 4: 947795. PMID 36278027 DOI: 10.3389/ftox.2022.947795  0.55
2021 Sethi S, Keil Stietz KP, Valenzuela AE, Klocke CR, Silverman JL, Puschner B, Pessah IN, Lein PJ. Developmental Exposure to a Human-Relevant Polychlorinated Biphenyl Mixture Causes Behavioral Phenotypes That Vary by Sex and Genotype in Juvenile Mice Expressing Human Mutations That Modulate Neuronal Calcium. Frontiers in Neuroscience. 15: 766826. PMID 34938155 DOI: 10.3389/fnins.2021.766826  0.495
2021 Keil Stietz KP, Sethi S, Klocke CR, de Ruyter TE, Wilson MD, Pessah IN, Lein PJ. Sex and Genotype Modulate the Dendritic Effects of Developmental Exposure to a Human-Relevant Polychlorinated Biphenyls Mixture in the Juvenile Mouse. Frontiers in Neuroscience. 15: 766802. PMID 34924936 DOI: 10.3389/fnins.2021.766802  0.569
2021 Ly C, Greb AC, Vargas MV, Duim WC, Grodzki ACG, Lein PJ, Olson DE. Transient Stimulation with Psychoplastogens Is Sufficient to Initiate Neuronal Growth. Acs Pharmacology & Translational Science. 4: 452-460. PMID 33860174 DOI: 10.1021/acsptsci.0c00065  0.349
2020 Panesar HK, Kennedy CL, Keil Stietz KP, Lein PJ. Polychlorinated Biphenyls (PCBs): Risk Factors for Autism Spectrum Disorder? Toxics. 8. PMID 32957475 DOI: 10.3390/Toxics8030070  0.3
2020 Supasai S, González EA, Rowland DJ, Hobson B, Bruun DA, Guignet MA, Soares S, Singh V, Wulff H, Saito N, Harvey DJ, Lein PJ. Acute administration of diazepam or midazolam minimally alters long-term neuropathological effects in the rat brain following acute intoxication with diisopropylfluorophosphate. European Journal of Pharmacology. 173538. PMID 32898549 DOI: 10.1016/J.Ejphar.2020.173538  0.305
2020 Berg EL, Pedersen LR, Pride MC, Petkova SP, Patten KT, Valenzuela AE, Wallis C, Bein KJ, Wexler A, Lein PJ, Silverman JL. Developmental exposure to near roadway pollution produces behavioral phenotypes relevant to neurodevelopmental disorders in juvenile rats. Translational Psychiatry. 10: 289. PMID 32807767 DOI: 10.1038/S41398-020-00978-0  0.315
2020 Jett DA, Sibrizzi CA, Blain RB, Hartman PA, Lein PJ, Taylor KW, Rooney AA. A national toxicology program systematic review of the evidence for long-term effects after acute exposure to sarin nerve agent. Critical Reviews in Toxicology. 1-17. PMID 32755358 DOI: 10.1080/10408444.2020.1787330  0.308
2020 Patten KT, González EA, Valenzuela A, Berg E, Wallis C, Garbow JR, Silverman JL, Bein KJ, Wexler AS, Lein PJ. Effects of early life exposure to traffic-related air pollution on brain development in juvenile Sprague-Dawley rats. Translational Psychiatry. 10: 166. PMID 32483143 DOI: 10.1038/S41398-020-0845-3  0.315
2020 Schmuck MR, Keil KP, Sethi S, Morgan RK, Lein PJ. Automated high content image analysis of dendritic arborization in primary mouse hippocampal and rat cortical neurons in culture. Journal of Neuroscience Methods. 108793. PMID 32461071 DOI: 10.1016/J.Jneumeth.2020.108793  0.43
2020 Goshi N, Morgan RK, Lein PJ, Seker E. A primary neural cell culture model to study neuron, astrocyte, and microglia interactions in neuroinflammation. Journal of Neuroinflammation. 17: 155. PMID 32393376 DOI: 10.1186/S12974-020-01819-Z  0.371
2020 Klocke C, Lein PJ. Evidence Implicating Non-Dioxin-Like Congeners as the Key Mediators of Polychlorinated Biphenyl (PCB) Developmental Neurotoxicity. International Journal of Molecular Sciences. 21. PMID 32033061 DOI: 10.3390/Ijms21031013  0.339
2020 Dunlap LE, Azinfar A, Ly C, Cameron LP, Viswanathan J, Tombari RJ, Myers-Turnbull D, Taylor JC, Grodzki AC, Lein PJ, Kokel D, Olson DE. Identification of Psychoplastogenic ,-Dimethylaminoisotryptamine (isoDMT) Analogues through Structure-Activity Relationship Studies. Journal of Medicinal Chemistry. PMID 31977208 DOI: 10.1021/Acs.Jmedchem.9B01404  0.36
2020 Matelski L, Morgan RK, Grodzki AC, Van de Water J, Lein PJ. Effects of cytokines on nuclear factor-kappa B, cell viability, and synaptic connectivity in a human neuronal cell line. Molecular Psychiatry. PMID 31965031 DOI: 10.1038/S41380-020-0647-2  0.409
2019 Klocke C, Sethi S, Lein PJ. The developmental neurotoxicity of legacy vs. contemporary polychlorinated biphenyls (PCBs): similarities and differences. Environmental Science and Pollution Research International. PMID 31713823 DOI: 10.1007/S11356-019-06723-5  0.37
2019 Yang J, Bruun DA, Wang C, Wan D, Reynolds CB, Phu K, Inceoglu B, Lein PJ, Hammock BD. Lipidomes of brain from rats acutely intoxicated with diisopropylfluorophosphate identifies potential therapeutic targets. Toxicology and Applied Pharmacology. 114749. PMID 31521729 DOI: 10.1016/J.Taap.2019.114749  0.311
2019 Walter KM, Dach K, Hayakawa K, Giersiefer S, Heuer H, Lein PJ, Fritsche E. Ontogenetic expression of thyroid hormone signaling genes: An in vitro and in vivo species comparison. Plos One. 14: e0221230. PMID 31513589 DOI: 10.1371/Journal.Pone.0221230  0.328
2019 Rude KM, Pusceddu MM, Keogh CE, Sladek JA, Rabasa G, Miller EN, Sethi S, Keil KP, Pessah IN, Lein PJ, Gareau MG. Developmental exposure to polychlorinated biphenyls (PCBs) in the maternal diet causes host-microbe defects in weanling offspring mice. Environmental Pollution (Barking, Essex : 1987). 253: 708-721. PMID 31336350 DOI: 10.1016/J.Envpol.2019.07.066  0.529
2019 Hennebelle M, Morgan RK, Sethi S, Zhang Z, Chen H, Grodzki AC, Lein PJ, Taha AY. Linoleic acid-derived metabolites constitute the majority of oxylipins in the rat pup brain and stimulate axonal growth in primary rat cortical neuron-glia co-cultures in a sex-dependent manner. Journal of Neurochemistry. PMID 31283837 DOI: 10.1111/Jnc.14818  0.364
2019 Walter KM, Miller GW, Chen X, Harvey DJ, Puschner B, Lein PJ. Changes in Thyroid Hormone Activity Disrupt Photomotor Behavior of Larval Zebrafish. Neurotoxicology. PMID 31121238 DOI: 10.1016/J.Neuro.2019.05.008  0.308
2019 Pravoverov K, Whiting K, Thapa S, Bushong T, Trang K, Lein PJ, Chandrasekaran V. MicroRNAs are Necessary for BMP-7-induced Dendritic Growth in Cultured Rat Sympathetic Neurons. Cellular and Molecular Neurobiology. PMID 31104181 DOI: 10.1007/S10571-019-00688-2  0.367
2019 Proskocil BJ, Grodzki ACG, Jacoby DB, Lein PJ, Fryer AD. Organophosphorus Pesticides Induce Cytokine Release from Differentiated Human THP1 Cells. American Journal of Respiratory Cell and Molecular Biology. PMID 30978295 DOI: 10.1165/Rcmb.2018-0257Oc  0.468
2019 Pessah IN, Lein PJ, Seegal RF, Sagiv SK. Neurotoxicity of polychlorinated biphenyls and related organohalogens. Acta Neuropathologica. PMID 30976975 DOI: 10.1007/S00401-019-01978-1  0.501
2019 Guignet M, Dhakal K, Flannery BM, Hobson BA, Zolkowska D, Dhir A, Bruun DA, Li S, Wahab A, Harvey DJ, Silverman JL, Rogawski MA, Lein PJ. Persistent behavior deficits, neuroinflammation, and oxidative stress in a rat model of acute organophosphate intoxication. Neurobiology of Disease. PMID 30905768 DOI: 10.1016/J.Nbd.2019.03.019  0.318
2019 Sethi S, Morgan R, Feng W, Lin Y, Li X, Luna C, Koch M, Bansal R, Duffel MW, Puschner B, Zoeller TR, Lehmler HJ, Pessah IN, Lein PJ. Comparative analyses of the 12 most abundant PCB congeners detected in human maternal serum for activity at the thyroid hormone receptor and ryanodine receptor. Environmental Science & Technology. PMID 30821444 DOI: 10.1021/Acs.Est.9B00535  0.539
2019 Keil KP, Sethi S, Wilson MD, Silverman JL, Pessah IN, Lein PJ. 34.1 GENETIC MUTATIONS AND ENVIRONMENTAL FACTORS THAT PROMOTE ADVERSE NEURODEVELOPMENTAL OUTCOMES IN PRECLINICAL MODELS Journal of the American Academy of Child & Adolescent Psychiatry. 58: S351. DOI: 10.1016/J.Jaac.2019.07.844  0.478
2018 Frank DF, Brander SM, Hasenbein S, Harvey DJ, Lein PJ, Geist J, Connon RE. Developmental exposure to environmentally relevant concentrations of bifenthrin alters transcription of mTOR and ryanodine receptor-dependent signaling molecules and impairs predator avoidance behavior across early life stages in inland silversides (Menidia beryllina). Aquatic Toxicology (Amsterdam, Netherlands). 206: 1-13. PMID 30414561 DOI: 10.1016/J.Aquatox.2018.10.014  0.332
2018 Keil KP, Sethi S, Lein PJ. Sex-dependent effects of 2,2',3,5',6-pentachlorobiphenyl (PCB 95) on dendritic arborization of primary mouse neurons. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 30395321 DOI: 10.1093/Toxsci/Kfy277  0.459
2018 Keil KP, Sethi S, Wilson MD, Silverman JL, Pessah IN, Lein PJ. Genetic mutations in Ca signaling alter dendrite morphology and social approach in juvenile mice. Genes, Brain, and Behavior. e12526. PMID 30311737 DOI: 10.1111/Gbb.12526  0.58
2018 Sethi S, Keil KP, Lein PJ. 3,3'-Dichlorobiphenyl (PCB 11) promotes dendritic arborization in primary rat cortical neurons via a CREB-dependent mechanism. Archives of Toxicology. PMID 30225637 DOI: 10.1007/S00204-018-2307-8  0.499
2018 Keil KP, Miller GW, Chen H, Sethi S, Schmuck MR, Dhakal K, Kim JW, Lein PJ. PCB 95 promotes dendritic growth in primary rat hippocampal neurons via mTOR-dependent mechanisms. Archives of Toxicology. PMID 30132043 DOI: 10.1007/S00204-018-2285-X  0.501
2018 Shaffo FC, Grodzki AC, Fryer AD, Lein PJ. Mechanisms of Organophosphorus Pesticide Toxicity in the Context of Airway Hyperreactivity and Asthma. American Journal of Physiology. Lung Cellular and Molecular Physiology. PMID 29952220 DOI: 10.1152/Ajplung.00211.2018  0.463
2018 Shaffo FC, Grodzki AC, Schelegle ES, Lein PJ. The Organophosphorus Pesticide Chlorpyrifos Induces Sex-Specific Airway Hyperreactivity in Adult Rats. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 29939342 DOI: 10.1093/Toxsci/Kfy158  0.303
2018 Frank DF, Miller GW, Harvey DJ, Brander SM, Geist J, Connon RE, Lein PJ. Bifenthrin causes transcriptomic alterations in mTOR and ryanodine receptor-dependent signaling and delayed hyperactivity in developing zebrafish (Danio rerio). Aquatic Toxicology (Amsterdam, Netherlands). 200: 50-61. PMID 29727771 DOI: 10.1016/J.Aquatox.2018.04.003  0.381
2018 Miller GW, Chandrasekaran V, Yaghoobi B, Lein PJ. Opportunities and challenges for using the zebrafish to study neuronal connectivity as an endpoint of developmental neurotoxicity. Neurotoxicology. PMID 29704525 DOI: 10.1016/J.Neuro.2018.04.016  0.416
2018 Fritsche E, Grandjean P, Crofton KM, Aschner M, Goldberg A, Heinonen T, Hessel EVS, Hogberg H, Bennekou SH, Lein PJ, Leist M, Mundy WR, Paparella M, Piersma AH, Sachana M, et al. Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes. Toxicology and Applied Pharmacology. PMID 29447839 DOI: 10.1016/J.Taap.2018.02.004  0.337
2018 Stamou M, Grodzki AC, van Oostrum M, Wollscheid B, Lein PJ. Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex. Journal of Neuroinflammation. 15: 7. PMID 29306331 DOI: 10.1186/S12974-017-1050-Z  0.38
2017 Sethi S, Keil KP, Lein PJ. Species and Sex Differences in the Morphogenic Response of Primary Rodent Neurons to 3,3'-Dichlorobiphenyl (PCB 11). Toxics. 6. PMID 29295518 DOI: 10.3390/Toxics6010004  0.458
2017 Frank DF, Miller GW, Connon RE, Geist J, Lein PJ. Transcriptomic profiling of mTOR and ryanodine receptor signaling molecules in developing zebrafish in the absence and presence of PCB 95. Peerj. 5: e4106. PMID 29201571 DOI: 10.7717/Peerj.4106  0.345
2017 Keil KP, Sethi S, Wilson MD, Chen H, Lein PJ. In vivo and in vitro sex differences in the dendritic morphology of developing murine hippocampal and cortical neurons. Scientific Reports. 7: 8486. PMID 28814778 DOI: 10.1038/S41598-017-08459-Z  0.424
2017 Mengeling BJ, Wei Y, Dobrawa LN, Streekstra M, Louisse J, Singh V, Singh L, Lein PJ, Wulff H, Murk AJ, Furlow JD. A multi-tiered, in vivo, quantitative assay suite for environmental disruptors of thyroid hormone signaling. Aquatic Toxicology (Amsterdam, Netherlands). 190: 1-10. PMID 28662416 DOI: 10.1016/J.Aquatox.2017.06.019  0.332
2017 Chapman CAR, Wang L, Chen H, Garrison J, Lein PJ, Seker E. Nanoporous Gold Biointerfaces: Modifying Nanostructure to Control Neural Cell Coverage and Enhance Electrophysiological Recording Performance. Advanced Functional Materials. 27. PMID 28626362 DOI: 10.1002/Adfm.201604631  0.32
2017 Sethi S, Keil KP, Chen H, Hayakawa K, Li X, Lin Y, Lehmler HJ, Puschner B, Lein PJ. Detection of 3,3'-Dichlorobiphenyl in Human Maternal Plasma and Its Effects on Axonal and Dendritic Growth in Primary Rat Neurons. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 28510766 DOI: 10.1093/Toxsci/Kfx100  0.462
2017 Kania-Korwel I, Lukasiewicz T, Barnhart CD, Stamou M, Chung H, Kelly KM, Bandiera S, Lein PJ, Lehmler HJ. Congener-Specific Disposition of Chiral Polychlorinated Biphenyls in Lactating Mice and Their Offspring: Implications for PCB Developmental Neurotoxicity. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 28431184 DOI: 10.1093/Toxsci/Kfx071  0.304
2017 Chen H, Judkins J, Thomas C, Wu M, Khoury L, Benjamin CG, Pacione D, Golfinos JG, Kumthekar P, Ghamsari F, Chen L, Lein P, Chetkovich DM, Snuderl M, Horbinski C. Mutant IDH1 and seizures in patients with glioma. Neurology. PMID 28404805 DOI: 10.1212/Wnl.0000000000003911  0.517
2017 Sisó S, Hobson BA, Harvey DJ, Bruun DA, Rowland DJ, Garbow JR, Lein PJ. Spatiotemporal Progression and Remission of Lesions in the Rat Brain Following Acute Intoxication with Diisopropylfluorophosphate. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 28329845 DOI: 10.1093/Toxsci/Kfx048  0.339
2017 Wilson MD, Sethi S, Lein PJ, Keil KP. Valid Statistical Approaches for Analyzing Sholl Data: Mixed Effects versus Simple Linear Models. Journal of Neuroscience Methods. PMID 28104486 DOI: 10.1016/J.Jneumeth.2017.01.003  0.3
2017 Proskocil B, Lein P, Jacoby D, Fryer A. Organophosphorus pesticides increase inflammatory cytokines by activating macrophage Mac-1 European Respiratory Journal. 50. DOI: 10.1183/1393003.Congress-2017.Pa4926  0.479
2017 Chen H, Judkins J, Ghamsari F, Lein P, Horbinski C. OS05.1 The D-2-hydroxyglutarate product of mutant IDH1 induces synchronized neuronal firing via NMDA receptor activation Neuro-Oncology. 19: iii8-iii9. DOI: 10.1093/Neuonc/Nox036.028  0.556
2016 Voorhees JR, Rohlman DS, Lein PJ, Pieper AA. Neurotoxicity in Preclinical Models of Occupational Exposure to Organophosphorus Compounds. Frontiers in Neuroscience. 10: 590. PMID 28149268 DOI: 10.3389/Fnins.2016.00590  0.348
2016 Chen H, Streifel KM, Singh V, Yang D, Mangini L, Wulff H, Lein PJ. BDE-47 and BDE-49 Inhibit Axonal Growth in Primary Rat Hippocampal Neuron-Glia Co-Cultures via Ryanodine Receptor-Dependent Mechanisms. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 28003438 DOI: 10.1093/Toxsci/Kfw259  0.497
2016 Chapman CA, Chen H, Stamou M, Lein PJ, Seker E. Mechanisms of Reduced Astrocyte Surface Coverage in Cortical Neuron-Glia Co-cultures on Nanoporous Gold Surfaces. Cellular and Molecular Bioengineering. 9: 433-442. PMID 27795742 DOI: 10.1007/S12195-016-0449-4  0.329
2016 Pessah IN, Rogawski MA, Tancredi DJ, Wulff H, Zolkowska D, Bruun DA, Hammock BD, Lein PJ. Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents. Annals of the New York Academy of Sciences. PMID 27467073 DOI: 10.1111/Nyas.13137  0.514
2016 Aschner M, Ceccatelli S, Daneshian M, Fritsche E, Hasiwa N, Hartung T, Hogberg HT, Leist M, Li A, Mundi WR, Padilla S, Piersma AH, Bal-Price A, Seiler A, Westerink R, ... ... Lein P, et al. Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use. Altex. PMID 27452664 DOI: 10.14573/Altex.1604201  0.322
2016 Lee YS, Lewis JA, Ippolito DL, Hussainzada N, Lein PJ, Jackson DA, Stallings JD. Repeated exposure to neurotoxic levels of chlorpyrifos alters hippocampal expression of neurotrophins and neuropeptides. Toxicology. PMID 26775027 DOI: 10.1016/J.Tox.2016.01.001  0.355
2016 Chen H, Judkins J, Ghamsari F, Lein P, Horbinski C. QLIF-03. MUTANT IDH1 PROMOTES TUMOR-ASSOCIATED EPILEPSY IN GLIOMA PATIENTS Neuro-Oncology. 18: vi156-vi156. DOI: 10.1093/Neuonc/Now212.649  0.463
2015 Courter LA, Shaffo FC, Ghogha A, Parrish DJ, Lorentz CU, Habecker BA, Lein PJ. BMP7-Induced Dendritic Growth in Sympathetic Neurons Requires p75(NTR) Signaling. Developmental Neurobiology. PMID 26663679 DOI: 10.1002/Dneu.22371  0.488
2015 Bui-Nguyen TM, Baer CE, Lewis JA, Yang D, Lein PJ, Jackson DA. Dichlorvos exposure results in large scale disruption of energy metabolism in the liver of the zebrafish, Danio rerio. Bmc Genomics. 16: 853. PMID 26499117 DOI: 10.1186/S12864-015-1941-2  0.314
2015 Chandrasekaran V, Lea C, Sosa JC, Higgins D, Lein PJ. Reactive oxygen species are involved in BMP-induced dendritic growth in cultured rat sympathetic neurons. Molecular and Cellular Neurosciences. 67: 116-125. PMID 26079955 DOI: 10.1016/J.Mcn.2015.06.007  0.608
2015 Proskocil BJ, Bruun DA, Garg JA, Villagomez CC, Jacoby DB, Lein PJ, Fryer AD. Sensitization Can Influence Mechanisms of Organophosphorus Pesticide-Induced Airway Hyperreactivity. American Journal of Respiratory Cell and Molecular Biology. PMID 25897622 DOI: 10.1165/Rcmb.2014-0444Oc  0.475
2015 Bruun DA, Cao Z, Inceoglu B, Vito ST, Austin AT, Hulsizer S, Hammock BD, Tancredi DJ, Rogawski MA, Pessah IN, Lein PJ. Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures. Neuropharmacology. 95: 332-42. PMID 25882826 DOI: 10.1016/J.Neuropharm.2015.03.035  0.551
2015 Li Y, Lein PJ, Ford GD, Liu C, Stovall KC, White TE, Bruun DA, Tewolde T, Gates AS, Distel TJ, Surles-Zeigler MC, Ford BD. Neuregulin-1 inhibits neuroinflammatory responses in a rat model of organophosphate-nerve agent-induced delayed neuronal injury. Journal of Neuroinflammation. 12: 64. PMID 25880399 DOI: 10.1186/S12974-015-0283-Y  0.337
2015 Harrill JA, Chen H, Streifel KM, Yang D, Mundy WR, Lein PJ. Ontogeny of biochemical, morphological and functional parameters of synaptogenesis in primary cultures of rat hippocampal and cortical neurons. Molecular Brain. 8: 10. PMID 25757474 DOI: 10.1186/S13041-015-0099-9  0.404
2015 Chapman CA, Chen H, Stamou M, Biener J, Biener MM, Lein PJ, Seker E. Nanoporous gold as a neural interface coating: effects of topography, surface chemistry, and feature size. Acs Applied Materials & Interfaces. 7: 7093-100. PMID 25706691 DOI: 10.1021/Acsami.5B00410  0.307
2015 Cao Z, Zou X, Cui Y, Hulsizer S, Lein PJ, Wulff H, Pessah IN. Rapid throughput analysis demonstrates that chemicals with distinct seizurogenic mechanisms differentially alter Ca2+ dynamics in networks formed by hippocampal neurons in culture. Molecular Pharmacology. 87: 595-605. PMID 25583085 DOI: 10.1124/Mol.114.096701  0.541
2015 Grodzki AC, Poola B, Pasupuleti N, Nantz MH, Lein PJ, Gorin F. A novel carboline derivative inhibits nitric oxide formation in macrophages independent of effects on tumor necrosis factor α and interleukin-1β expression. The Journal of Pharmacology and Experimental Therapeutics. 352: 438-47. PMID 25538105 DOI: 10.1124/Jpet.114.220186  0.318
2015 Lein P. The developmental neurotoxicity of non-dioxin-like PCBs: Sensitization of ryanodine receptors interferes with neurodevelopmental processes that determine neuronal connectivity Neurotoxicology and Teratology. 49: 118. DOI: 10.1016/J.Ntt.2015.04.063  0.392
2014 Vito ST, Austin AT, Banks CN, Inceoglu B, Bruun DA, Zolkowska D, Tancredi DJ, Rogawski MA, Hammock BD, Lein PJ. Post-exposure administration of diazepam combined with soluble epoxide hydrolase inhibition stops seizures and modulates neuroinflammation in a murine model of acute TETS intoxication. Toxicology and Applied Pharmacology. 281: 185-94. PMID 25448683 DOI: 10.1016/J.Taap.2014.10.001  0.314
2014 Moore CE, Lein PJ, Puschner B. Microcystins alter chemotactic behavior in Caenorhabditis elegans by selectively targeting the AWA sensory neuron. Toxins. 6: 1813-36. PMID 24918360 DOI: 10.3390/Toxins6061813  0.425
2014 Lesiak A, Zhu M, Chen H, Appleyard SM, Impey S, Lein PJ, Wayman GA. The environmental neurotoxicant PCB 95 promotes synaptogenesis via ryanodine receptor-dependent miR132 upregulation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 717-25. PMID 24431430 DOI: 10.1523/Jneurosci.2884-13.2014  0.312
2014 Yang D, Kania-Korwel I, Ghogha A, Chen H, Stamou M, Bose DD, Pessah IN, Lehmler HJ, Lein PJ. PCB 136 atropselectively alters morphometric and functional parameters of neuronal connectivity in cultured rat hippocampal neurons via ryanodine receptor-dependent mechanisms. Toxicological Sciences : An Official Journal of the Society of Toxicology. 138: 379-92. PMID 24385416 DOI: 10.1093/Toxsci/Kft334  0.66
2013 Wu X, Kania-Korwel I, Chen H, Stamou M, Dammanahalli KJ, Duffel M, Lein PJ, Lehmler HJ. Metabolism of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) atropisomers in tissue slices from phenobarbital or dexamethasone-induced rats is sex-dependent. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 43: 933-47. PMID 23581876 DOI: 10.3109/00498254.2013.785626  0.307
2013 Proskocil BJ, Bruun DA, Jacoby DB, van Rooijen N, Lein PJ, Fryer AD. Macrophage TNF-α mediates parathion-induced airway hyperreactivity in guinea pigs. American Journal of Physiology. Lung Cellular and Molecular Physiology. 304: L519-29. PMID 23377347 DOI: 10.1152/Ajplung.00381.2012  0.466
2013 Stamou M, Streifel KM, Goines PE, Lein PJ. Neuronal connectivity as a convergent target of gene × environment interactions that confer risk for Autism Spectrum Disorders. Neurotoxicology and Teratology. 36: 3-16. PMID 23269408 DOI: 10.1016/J.Ntt.2012.12.001  0.389
2012 Ellison CA, Crane AL, Bonner MR, Knaak JB, Browne RW, Lein PJ, Olson JR. PON1 status does not influence cholinesterase activity in Egyptian agricultural workers exposed to chlorpyrifos. Toxicology and Applied Pharmacology. 265: 308-15. PMID 22975224 DOI: 10.1016/J.Taap.2012.08.031  0.307
2012 Kania-Korwel I, Barnhart CD, Stamou M, Truong KM, El-Komy MH, Lein PJ, Veng-Pedersen P, Lehmler HJ. 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice. Environmental Science & Technology. 46: 11393-401. PMID 22974126 DOI: 10.1021/Es302810T  0.312
2012 Cao Z, Hammock BD, McCoy M, Rogawski MA, Lein PJ, Pessah IN. Tetramethylenedisulfotetramine alters Ca²⁺ dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation. Toxicological Sciences : An Official Journal of the Society of Toxicology. 130: 362-72. PMID 22889812 DOI: 10.1093/Toxsci/Kfs244  0.552
2012 Li Y, Lein PJ, Liu C, Bruun DA, Giulivi C, Ford GD, Tewolde T, Ross-Inta C, Ford BD. Neuregulin-1 is neuroprotective in a rat model of organophosphate-induced delayed neuronal injury. Toxicology and Applied Pharmacology. 262: 194-204. PMID 22583949 DOI: 10.1016/J.Taap.2012.05.001  0.377
2012 Wayman GA, Bose DD, Yang D, Lesiak A, Bruun D, Impey S, Ledoux V, Pessah IN, Lein PJ. PCB-95 modulates the calcium-dependent signaling pathway responsible for activity-dependent dendritic growth. Environmental Health Perspectives. 120: 1003-9. PMID 22534176 DOI: 10.1289/Ehp.1104833  0.641
2012 Wayman GA, Yang D, Bose DD, Lesiak A, Ledoux V, Bruun D, Pessah IN, Lein PJ. PCB-95 promotes dendritic growth via ryanodine receptor-dependent mechanisms. Environmental Health Perspectives. 120: 997-1002. PMID 22534141 DOI: 10.1289/Ehp.1104832  0.643
2012 Ghogha A, Bruun DA, Lein PJ. Inducing dendritic growth in cultured sympathetic neurons. Journal of Visualized Experiments : Jove. PMID 22473299 DOI: 10.3791/3546  0.499
2012 van Thriel C, Westerink RH, Beste C, Bale AS, Lein PJ, Leist M. Translating neurobehavioural endpoints of developmental neurotoxicity tests into in vitro assays and readouts. Neurotoxicology. 33: 911-24. PMID 22008243 DOI: 10.1016/J.Neuro.2011.10.002  0.455
2012 Kim KH, Bose DD, Ghogha A, Riehl J, Zhang R, Barnhart CD, Lein PJ, Pessah IN. Erratum: “ Para – and Ortho -SubstitutionsAre Key Determinants of Polybrominated Diphenyl Ether Activity toward RyanodineReceptors and Neurotoxicity” Environmental Health Perspectives. 120. DOI: 10.1289/ehp.120-a189  0.418
2011 Grodzki AC, Ghogha A, Mangini L, Fryer AD, Lein PJ. IFNγ Increases M2 Muscarinic Receptor Expression in Cultured Sympathetic Neurons. Current Neurobiology. 2: 23-29. PMID 23226931  0.434
2011 Lein PJ, Barnhart CD, Pessah IN. Acute hippocampal slice preparation and hippocampal slice cultures. Methods in Molecular Biology (Clifton, N.J.). 758: 115-34. PMID 21815062 DOI: 10.1007/978-1-61779-170-3_8  0.568
2011 Garred MM, Wang MM, Guo X, Harrington CA, Lein PJ. Transcriptional responses of cultured rat sympathetic neurons during BMP-7-induced dendritic growth. Plos One. 6: e21754. PMID 21765909 DOI: 10.1371/Journal.Pone.0021754  0.495
2011 Ellison CA, Smith JN, Lein PJ, Olson JR. Pharmacokinetics and pharmacodynamics of chlorpyrifos in adult male Long-Evans rats following repeated subcutaneous exposure to chlorpyrifos. Toxicology. 287: 137-44. PMID 21708215 DOI: 10.1016/J.Tox.2011.06.010  0.313
2011 Li Y, Lein PJ, Liu C, Bruun DA, Tewolde T, Ford G, Ford BD. Spatiotemporal pattern of neuronal injury induced by DFP in rats: a model for delayed neuronal cell death following acute OP intoxication. Toxicology and Applied Pharmacology. 253: 261-9. PMID 21513723 DOI: 10.1016/J.Taap.2011.03.026  0.373
2011 Yang D, Lauridsen H, Buels K, Chi LH, La Du J, Bruun DA, Olson JR, Tanguay RL, Lein PJ. Chlorpyrifos-oxon disrupts zebrafish axonal growth and motor behavior. Toxicological Sciences : An Official Journal of the Society of Toxicology. 121: 146-59. PMID 21346248 DOI: 10.1093/Toxsci/Kfr028  0.413
2011 Rohlman DS, Anger WK, Lein PJ. Correlating neurobehavioral performance with biomarkers of organophosphorous pesticide exposure. Neurotoxicology. 32: 268-76. PMID 21182866 DOI: 10.1016/J.Neuro.2010.12.008  0.304
2011 Abdu E, Bruun DA, Yang D, Yang J, Inceoglu B, Hammock BD, Alkayed NJ, Lein PJ. Epoxyeicosatrienoic acids enhance axonal growth in primary sensory and cortical neuronal cell cultures. Journal of Neurochemistry. 117: 632-42. PMID 21155804 DOI: 10.1111/J.1471-4159.2010.07139.X  0.404
2011 Kim KH, Bose DD, Ghogha A, Riehl J, Zhang R, Barnhart CD, Lein PJ, Pessah IN. Para- and ortho-substitutions are key determinants of polybrominated diphenyl ether activity toward ryanodine receptors and neurotoxicity. Environmental Health Perspectives. 119: 519-26. PMID 21106467 DOI: 10.1289/Ehp.1002728  0.549
2010 Proskocil BJ, Bruun DA, Thompson CM, Fryer AD, Lein PJ. Organophosphorus pesticides decrease M2 muscarinic receptor function in guinea pig airway nerves via indirect mechanisms. Plos One. 5: e10562. PMID 20479945 DOI: 10.1371/Journal.Pone.0010562  0.506
2010 Pessah IN, Cherednichenko G, Lein PJ. Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity. Pharmacology & Therapeutics. 125: 260-85. PMID 19931307 DOI: 10.1016/J.Pharmthera.2009.10.009  0.546
2010 Lein PJ, Fryer AD, Higgins D. Cell Culture: Autonomic and Enteric Neurons Encyclopedia of Neuroscience. 625-632. DOI: 10.1016/B978-008045046-9.00626-4  0.55
2010 Lein PJ, Kim KH, Berman RF, Pessah IN. Exposure of the developing brain to polychlorinated biphenyls influences the susceptibility of the adult brain to stress Developmental Neurotoxicology Research: Principles, Models, Techniques, Strategies, and Mechanisms. 211-229. DOI: 10.1002/9780470917060.ch12  0.427
2009 Halladay AK, Amaral D, Aschner M, Bolivar VJ, Bowman A, DiCicco-Bloom E, Hyman SL, Keller F, Lein P, Pessah I, Restifo L, Threadgill DW. Animal models of autism spectrum disorders: information for neurotoxicologists. Neurotoxicology. 30: 811-21. PMID 19596370 DOI: 10.1016/J.Neuro.2009.07.002  0.507
2009 Yang D, Kim KH, Phimister A, Bachstetter AD, Ward TR, Stackman RW, Mervis RF, Wisniewski AB, Klein SL, Kodavanti PR, Anderson KA, Wayman G, Pessah IN, Lein PJ. Developmental exposure to polychlorinated biphenyls interferes with experience-dependent dendritic plasticity and ryanodine receptor expression in weanling rats. Environmental Health Perspectives. 117: 426-35. PMID 19337518 DOI: 10.1289/Ehp.11771  0.653
2009 Kim WY, Gonsiorek EA, Barnhart C, Davare MA, Engebose AJ, Lauridsen H, Bruun D, Lesiak A, Wayman G, Bucelli R, Higgins D, Lein PJ. Statins decrease dendritic arborization in rat sympathetic neurons by blocking RhoA activation. Journal of Neurochemistry. 108: 1057-71. PMID 19209406 DOI: 10.1111/J.1471-4159.2008.05854.X  0.789
2008 Andres DA, Shi GX, Bruun D, Barnhart C, Lein PJ. Rit signaling contributes to interferon-gamma-induced dendritic retraction via p38 mitogen-activated protein kinase activation. Journal of Neurochemistry. 107: 1436-47. PMID 18957053 DOI: 10.1111/J.1471-4159.2008.05708.X  0.494
2008 Boswell BA, Lein PJ, Musil LS. Cross-talk between fibroblast growth factor and bone morphogenetic proteins regulates gap junction-mediated intercellular communication in lens cells. Molecular Biology of the Cell. 19: 2631-41. PMID 18400943 DOI: 10.1091/Mbc.E08-02-0124  0.337
2008 Pessah IN, Seegal RF, Lein PJ, LaSalle J, Yee BK, Van De Water J, Berman RF. Immunologic and neurodevelopmental susceptibilities of autism. Neurotoxicology. 29: 532-45. PMID 18394707 DOI: 10.1016/J.Neuro.2008.02.006  0.496
2008 Proskocil BJ, Bruun DA, Lorton JK, Blensly KC, Jacoby DB, Lein PJ, Fryer AD. Antigen sensitization influences organophosphorus pesticide-induced airway hyperreactivity. Environmental Health Perspectives. 116: 381-8. PMID 18335107 DOI: 10.1289/Ehp.10694  0.466
2008 Bucelli RC, Gonsiorek EA, Kim WY, Bruun D, Rabin RA, Higgins D, Lein PJ. Statins decrease expression of the proinflammatory neuropeptides calcitonin gene-related peptide and substance P in sensory neurons. The Journal of Pharmacology and Experimental Therapeutics. 324: 1172-80. PMID 18079356 DOI: 10.1124/Jpet.107.132795  0.767
2008 Yang D, Howard A, Bruun D, Ajua-Alemanj M, Pickart C, Lein PJ. Chlorpyrifos and chlorpyrifos-oxon inhibit axonal growth by interfering with the morphogenic activity of acetylcholinesterase. Toxicology and Applied Pharmacology. 228: 32-41. PMID 18076960 DOI: 10.1016/J.Taap.2007.11.005  0.439
2007 Lein PJ, Guo X, Shi GX, Moholt-Siebert M, Bruun D, Andres DA. The novel GTPase Rit differentially regulates axonal and dendritic growth. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 4725-36. PMID 17460085 DOI: 10.1523/Jneurosci.5633-06.2007  0.499
2007 Lein PJ, Yang D, Bachstetter AD, Tilson HA, Harry GJ, Mervis RF, Kodavanti PR. Ontogenetic alterations in molecular and structural correlates of dendritic growth after developmental exposure to polychlorinated biphenyls. Environmental Health Perspectives. 115: 556-63. PMID 17450224 DOI: 10.1289/Ehp.9773  0.447
2006 Pin S, Chen H, Lein PJ, Wang MM. Nucleic acid binding agents exert local toxic effects on neurites via a non-nuclear mechanism. Journal of Neurochemistry. 96: 1253-66. PMID 16441515 DOI: 10.1111/J.1471-4159.2006.03653.X  0.382
2005 Howard AS, Bucelli R, Jett DA, Bruun D, Yang D, Lein PJ. Chlorpyrifos exerts opposing effects on axonal and dendritic growth in primary neuronal cultures. Toxicology and Applied Pharmacology. 207: 112-24. PMID 16102564 DOI: 10.1016/J.Taap.2004.12.008  0.713
2005 Lein PJ, Fryer AD. Organophosphorus insecticides induce airway hyperreactivity by decreasing neuronal M2 muscarinic receptor function independent of acetylcholinesterase inhibition. Toxicological Sciences : An Official Journal of the Society of Toxicology. 83: 166-76. PMID 15470232 DOI: 10.1093/Toxsci/Kfi001  0.501
2004 Shen W, Finnegan S, Lein P, Sullivan S, Slaughter M, Higgins D. Bone morphogenetic proteins regulate ionotropic glutamate receptors in human retina. The European Journal of Neuroscience. 20: 2031-7. PMID 15450082 DOI: 10.1111/J.1460-9568.2004.03681.X  0.465
2004 Kim IJ, Drahushuk KM, Kim WY, Gonsiorek EA, Lein P, Andres DA, Higgins D. Extracellular signal-regulated kinases regulate dendritic growth in rat sympathetic neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 3304-12. PMID 15056710 DOI: 10.1523/Jneurosci.3286-03.2004  0.771
2004 Fryer AD, Lein PJ, Howard AS, Yost BL, Beckles RA, Jett DA. Mechanisms of organophosphate insecticide-induced airway hyperreactivity. American Journal of Physiology. Lung Cellular and Molecular Physiology. 286: L963-9. PMID 14704222 DOI: 10.1152/Ajplung.00343.2003  0.505
2003 Howard AS, Fitzpatrick R, Pessah I, Kostyniak P, Lein PJ. Polychlorinated biphenyls induce caspase-dependent cell death in cultured embryonic rat hippocampal but not cortical neurons via activation of the ryanodine receptor. Toxicology and Applied Pharmacology. 190: 72-86. PMID 12831785 DOI: 10.1016/S0041-008X(03)00156-X  0.611
2002 Lein PJ, Beck HN, Chandrasekaran V, Gallagher PJ, Chen HL, Lin Y, Guo X, Kaplan PL, Tiedge H, Higgins D. Glia induce dendritic growth in cultured sympathetic neurons by modulating the balance between bone morphogenetic proteins (BMPs) and BMP antagonists. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 10377-87. PMID 12451137 DOI: 10.1523/Jneurosci.22-23-10377.2002  0.602
2002 Roth JA, Horbinski C, Higgins D, Lein P, Garrick MD. Mechanisms of manganese-induced rat pheochromocytoma (PC12) cell death and cell differentiation. Neurotoxicology. 23: 147-57. PMID 12224755 DOI: 10.1016/S0161-813X(01)00077-8  0.636
2002 Schuh RA, Lein PJ, Beckles RA, Jett DA. Noncholinesterase mechanisms of chlorpyrifos neurotoxicity: altered phosphorylation of Ca2+/cAMP response element binding protein in cultured neurons. Toxicology and Applied Pharmacology. 182: 176-85. PMID 12140181 DOI: 10.1006/Taap.2002.9445  0.449
2002 Kim IJ, Beck HN, Lein PJ, Higgins D. Interferon gamma induces retrograde dendritic retraction and inhibits synapse formation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 4530-9. PMID 12040060  0.643
2002 Lein PJ, Beck HN, Chandrasekaran V, Gallagher PJ, Chen H, Lin Y, Guo X, Kaplan PL, Tiedge H, Higgins D. Glia Induce Dendritic Growth in Cultured Sympathetic Neurons by Modulating the Balance between Bone Morphogenetic Proteins (BMPs) and BMP Antagonists The Journal of Neuroscience. 22: 10377-10387. DOI: 10.1523/JNEUROSCI.22-23-10377.2002  0.47
2002 Kim I, Beck HN, Lein PJ, Higgins D. Interferon γ Induces Retrograde Dendritic Retraction and Inhibits Synapse Formation The Journal of Neuroscience. 22: 4530-4539. DOI: 10.1523/Jneurosci.22-11-04530.2002  0.576
2001 Dattatreyamurty B, Roux E, Horbinski C, Kaplan PL, Robak LA, Beck HN, Lein P, Higgins D, Chandrasekaran V. Cerebrospinal fluid contains biologically active bone morphogenetic protein-7. Experimental Neurology. 172: 273-81. PMID 11716552 DOI: 10.1006/Exnr.2001.7728  0.656
2001 Beck HN, Drahushuk K, Jacoby DB, Higgins D, Lein PJ. Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons. Bmc Neuroscience. 2: 12. PMID 11580864 DOI: 10.1186/1471-2202-2-12  0.796
2001 Guo X, Lin Y, Horbinski C, Drahushuk KM, Kim IJ, Kaplan PL, Lein P, Wang T, Higgins D. Dendritic growth induced by BMP-7 requires Smad1 and proteasome activity. Journal of Neurobiology. 48: 120-30. PMID 11438941 DOI: 10.1002/Neu.1046  0.776
1999 Guo X, Chandrasekaran V, Lein P, Kaplan PL, Higgins D. Leukemia inhibitory factor and ciliary neurotrophic factor cause dendritic retraction in cultured rat sympathetic neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 2113-21. PMID 10066264 DOI: 10.1523/Jneurosci.19-06-02113.1999  0.565
1998 Gadient RA, Lein P, Higgins D, Patterson PH. Effect of leukemia inhibitory factor (LIF) on the morphology and survival of cultured hippocampal neurons and glial cells. Brain Research. 798: 140-6. PMID 9666105 DOI: 10.1016/S0006-8993(98)00236-4  0.558
1997 Guo X, Metzler-Northrup J, Lein P, Rueger D, Higgins D. Leukemia inhibitory factor and ciliary neurotrophic factor regulate dendritic growth in cultures of rat sympathetic neurons. Brain Research. Developmental Brain Research. 104: 101-10. PMID 9466712 DOI: 10.1016/S0165-3806(97)00142-9  0.593
1997 Higgins D, Burack M, Lein P, Banker G. Mechanisms of neuronal polarity. Current Opinion in Neurobiology. 7: 599-604. PMID 9384542 DOI: 10.1016/S0959-4388(97)80078-5  0.538
1996 Lein P, Higgins D. Antibodies to β1 integrins inhibit dendritic growth in rat sympathetic neurons. Biomedical Research (Aligarh, India). 7: 101-111. PMID 29238133  0.49
1996 Lein P, Guo X, Hedges AM, Rueger D, Johnson M, Higgins D. The effects of extracellular matrix and osteogenic protein-1 on the morphological differentiation of rat sympathetic neurons. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 14: 203-15. PMID 8842799 DOI: 10.1016/0736-5748(96)00008-1  0.581
1995 Lein P, Johnson M, Guo X, Rueger D, Higgins D. Osteogenic protein-1 induces dendritic growth in rat sympathetic neurons. Neuron. 15: 597-605. PMID 7546739 DOI: 10.1016/0896-6273(95)90148-5  0.589
1992 Lein PJ, Banker GA, Higgins D. Laminin selectively enhances axonal growth and accelerates the development of polarity by hippocampal neurons in culture. Brain Research. Developmental Brain Research. 69: 191-7. PMID 1424096 DOI: 10.1016/0165-3806(92)90159-T  0.529
1991 Lein PJ, Higgins D, Turner DC, Flier LA, Terranova VP. The NC1 domain of type IV collagen promotes axonal growth in sympathetic neurons through interaction with the alpha 1 beta 1 integrin. The Journal of Cell Biology. 113: 417-28. PMID 2010469 DOI: 10.1083/Jcb.113.2.417  0.53
1991 Lein PJ, Higgins D. Protein synthesis is required for the initiation of dendritic growth in embryonic rat sympathetic neurons in vitro. Brain Research. Developmental Brain Research. 60: 187-96. PMID 1716531 DOI: 10.1016/0165-3806(91)90047-M  0.546
1990 Bruckenstein DA, Lein PJ, Higgins D, Fremeau RT. Distinct spatial localization of specific mRNAs in cultured sympathetic neurons. Neuron. 5: 809-19. PMID 2148487 DOI: 10.1016/0896-6273(90)90340-L  0.489
1989 Lein PJ, Higgins D. Laminin and a basement membrane extract have different effects on axonal and dendritic outgrowth from embryonic rat sympathetic neurons in vitro. Developmental Biology. 136: 330-45. PMID 2479584 DOI: 10.1016/0012-1606(89)90260-1  0.56
1988 Kung MP, Nickerson PA, Sansone FM, Olson JR, Kostyniak PJ, Adolf MA, Lein PJ, Roth JA. Effect of short-term exposure to hexachlorophene on rat brain cell specific marker enzymes. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology. 11: 519-27. PMID 2906023 DOI: 10.1016/0272-0590(88)90116-9  0.339
Low-probability matches (unlikely to be authored by this person)
2020 Pressly B, Vasylieva N, Barnych B, Singh V, Singh L, Bruun DA, Hwang SH, Chen YJ, Fettinger JC, Johnnides S, Lein PJ, Yang J, Hammock BD, Wulff H. Comparison of the toxicokinetics of the convulsants picrotoxinin and tetramethylenedisulfotetramine (TETS) in mice. Archives of Toxicology. PMID 32239239 DOI: 10.1007/S00204-020-02728-Z  0.299
2008 Dziennis S, Yang D, Cheng J, Anderson KA, Alkayed NJ, Hurn PD, Lein PJ. Developmental exposure to polychlorinated biphenyls influences stroke outcome in adult rats. Environmental Health Perspectives. 116: 474-80. PMID 18414629 DOI: 10.1289/Ehp.10828  0.299
2020 González EA, Rindy AC, Guignet MA, Calsbeek JJ, Bruun DA, Dhir A, Andrew P, Saito N, Rowland DJ, Harvey DJ, Rogawski MA, Lein PJ. The chemical convulsant diisopropylfluorophosphate (DFP) causes persistent neuropathology in adult male rats independent of seizure activity. Archives of Toxicology. PMID 32303805 DOI: 10.1007/S00204-020-02747-W  0.298
2018 Walter KM, Miller GW, Chen X, Yaghoobi B, Puschner B, Lein PJ. Effects of Thyroid Hormone Disruption on the Ontogenetic Expression of Thyroid Hormone Signaling Genes in Developing Zebrafish (Danio rerio). General and Comparative Endocrinology. PMID 30448381 DOI: 10.1016/J.Ygcen.2018.11.007  0.297
2012 Banks CN, Lein PJ. A review of experimental evidence linking neurotoxic organophosphorus compounds and inflammation. Neurotoxicology. 33: 575-84. PMID 22342984 DOI: 10.1016/J.Neuro.2012.02.002  0.297
2015 Singleton ST, Lein PJ, Dadson OA, McGarrigle BP, Farahat FM, Farahat T, Bonner MR, Fenske RA, Galvin K, Lasarev MR, Anger WK, Rohlman DS, Olson JR. Longitudinal assessment of occupational exposures to the organophosphorous insecticides chlorpyrifos and profenofos in Egyptian cotton field workers. International Journal of Hygiene and Environmental Health. 218: 203-11. PMID 25466362 DOI: 10.1016/J.Ijheh.2014.10.005  0.296
2019 Bruun DA, Guignet M, Harvey DJ, Lein PJ. Pretreatment with pyridostigmine bromide has no effect on seizure behavior or 24 hour survival in the rat model of acute diisopropylfluorophosphate intoxication. Neurotoxicology. PMID 30853371 DOI: 10.1016/J.Neuro.2019.03.001  0.296
2017 Dach K, Bendt F, Huebenthal U, Giersiefer S, Lein PJ, Heuer H, Fritsche E. BDE-99 impairs differentiation of human and mouse NPCs into the oligodendroglial lineage by species-specific modes of action. Scientific Reports. 7: 44861. PMID 28317842 DOI: 10.1038/Srep44861  0.295
2014 Singleton ST, Lein PJ, Farahat FM, Farahat T, Bonner MR, Knaak JB, Olson JR. Characterization of α-cypermethrin exposure in Egyptian agricultural workers. International Journal of Hygiene and Environmental Health. 217: 538-45. PMID 24269189 DOI: 10.1016/J.Ijheh.2013.10.003  0.295
2015 Bal-Price A, Crofton KM, Sachana M, Shafer TJ, Behl M, Forsby A, Hargreaves A, Landesmann B, Lein PJ, Louisse J, Monnet-Tschudi F, Paini A, Rolaki A, Schrattenholz A, Suñol C, et al. Putative adverse outcome pathways relevant to neurotoxicity. Critical Reviews in Toxicology. 45: 83-91. PMID 25605028 DOI: 10.3109/10408444.2014.981331  0.293
2012 Lein PJ, Bonner MR, Farahat FM, Olson JR, Rohlman DS, Fenske RA, Lattal KM, Lasarev MR, Galvin K, Farahat TM, Anger WK. Experimental strategy for translational studies of organophosphorus pesticide neurotoxicity based on real-world occupational exposures to chlorpyrifos. Neurotoxicology. 33: 660-8. PMID 22240005 DOI: 10.1016/J.Neuro.2011.12.017  0.292
2022 Chen H, Carty RK, Bautista AC, Hayakawa KA, Lein PJ. Triiodothyronine or Antioxidants Block the Inhibitory Effects of BDE-47 and BDE-49 on Axonal Growth in Rat Hippocampal Neuron-Glia Co-Cultures. Toxics. 10. PMID 35202279 DOI: 10.3390/toxics10020092  0.291
2011 Farahat FM, Ellison CA, Bonner MR, McGarrigle BP, Crane AL, Fenske RA, Lasarev MR, Rohlman DS, Anger WK, Lein PJ, Olson JR. Biomarkers of chlorpyrifos exposure and effect in Egyptian cotton field workers. Environmental Health Perspectives. 119: 801-6. PMID 21224175 DOI: 10.1289/Ehp.1002873  0.291
2003 Chen HL, Lein PJ, Wang JY, Gash D, Hoffer BJ, Chiang YH. Expression of bone morphogenetic proteins in the brain during normal aging and in 6-hydroxydopamine-lesioned animals. Brain Research. 994: 81-90. PMID 14642451 DOI: 10.1016/J.Brainres.2003.09.020  0.291
2016 Bal-Price A, Lein PJ, Keil KP, Sethi S, Shafer T, Barenys M, Fritsche E, Sachana M, Meek ME. Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity. Neurotoxicology. PMID 27212452 DOI: 10.1016/J.Neuro.2016.05.010  0.29
2020 Dhir A, Bruun DA, Guignet M, Tsai YH, González E, Calsbeek J, Vu J, Saito N, Tancredi DJ, Harvey DJ, Lein PJ, Rogawski MA. Allopregnanolone and perampanel as adjuncts to midazolam for treating diisopropylfluorophosphate-induced status epilepticus in rats. Annals of the New York Academy of Sciences. PMID 32915470 DOI: 10.1111/Nyas.14479  0.29
2015 Flannery BM, Silverman JL, Bruun DA, Puhger KR, McCoy MR, Hammock BD, Crawley JN, Lein PJ. Behavioral assessment of NIH Swiss mice acutely intoxicated with tetramethylenedisulfotetramine. Neurotoxicology and Teratology. 47: 36-45. PMID 25446016 DOI: 10.1016/J.Ntt.2014.10.008  0.289
2020 Anger WK, Farahat FM, Lein PJ, Lasarev MR, Olson JR, Farahat TM, Rohlman DS. Magnitude of behavioral deficits varies with job-related chlorpyrifos exposure levels among Egyptian pesticide workers. Neurotoxicology. 77: 216-230. PMID 32006538 DOI: 10.1016/J.Neuro.2020.01.012  0.288
2020 vonderEmbse A, Tong JW, Lein PJ, Merrill ML. SUN-638 Perinatal DDE Exposure Disrupts Thermogenesis Early in Development Journal of the Endocrine Society. 4. DOI: 10.1210/Jendso/Bvaa046.1962  0.287
2010 Farahat FM, Fenske RA, Olson JR, Galvin K, Bonner MR, Rohlman DS, Farahat TM, Lein PJ, Anger WK. Chlorpyrifos exposures in Egyptian cotton field workers. Neurotoxicology. 31: 297-304. PMID 20193710 DOI: 10.1016/J.Neuro.2010.02.005  0.286
2023 da Costa Souza F, Grodzki ACG, Morgan RK, Zhang Z, Taha AY, Lein PJ. Oxidized linoleic acid metabolites regulate neuronal morphogenesis in vitro. Neurochemistry International. 105506. PMID 36758902 DOI: 10.1016/j.neuint.2023.105506  0.286
2016 Keil KP, Lein PJ. DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? Environmental Epigenetics. 2. PMID 27158529 DOI: 10.1093/Eep/Dvv012  0.285
2005 Lein P, Silbergeld E, Locke P, Goldberg AM. In vitro and other alternative approaches to developmental neurotoxicity testing (DNT). Environmental Toxicology and Pharmacology. 19: 735-44. PMID 21783550 DOI: 10.1016/J.Etap.2004.12.035  0.284
2013 Grodzki AC, Giulivi C, Lein PJ. Oxygen tension modulates differentiation and primary macrophage functions in the human monocytic THP-1 cell line. Plos One. 8: e54926. PMID 23355903 DOI: 10.1371/Journal.Pone.0054926  0.282
2015 Stamou M, Uwimana E, Flannery BM, Kania-Korwel I, Lehmler HJ, Lein PJ. Subacute nicotine co-exposure has no effect on 2,2',3,5',6- pentachlorobiphenyl disposition but alters hepatic cytochrome P450 expression in the male rat. Toxicology. 338: 59-68. PMID 26463278 DOI: 10.1016/J.Tox.2015.10.002  0.28
2012 Zolkowska D, Banks CN, Dhir A, Inceoglu B, Sanborn JR, McCoy MR, Bruun DA, Hammock BD, Lein PJ, Rogawski MA. Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine. The Journal of Pharmacology and Experimental Therapeutics. 341: 435-46. PMID 22328574 DOI: 10.1124/Jpet.111.190579  0.28
2019 Bruce M, Streifel KM, Boosalis CA, Heuer L, González EA, Li S, Harvey DJ, Lein PJ, Van de Water J. Acute peripheral immune activation alters cytokine expression and glial activation in the early postnatal rat brain. Journal of Neuroinflammation. 16: 200. PMID 31672161 DOI: 10.1186/S12974-019-1569-2  0.279
2019 Hobson BA, Rowland DJ, Sisó S, Guignet MA, Harmany ZT, Bandara S, Saito N, Harvey DJ, Bruun DA, Garbow JR, Chaudhari AJ, Lein PJ. TSPO PET Using [18F]PBR111 Reveals Persistent Neuroinflammation Following Acute Diisopropylfluorophosphate Intoxication in the Rat. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 31087103 DOI: 10.1093/Toxsci/Kfz096  0.279
2020 Tal T, Yaghoobi B, Lein PJ. Translational Toxicology in Zebrafish. Current Opinion in Toxicology. 23: 56-66. PMID 32656393 DOI: 10.1016/J.Cotox.2020.05.004  0.279
2013 Lein P. Interferon-gamma (IFNγ) causes dendrite retraction and synapse loss in rat sympathetic neurons in vivo Autonomic Neuroscience. 177: 25. DOI: 10.1016/j.autneu.2013.05.031  0.277
2003 Chang CF, Lin SZ, Chiang YH, Morales M, Chou J, Lein P, Chen HL, Hoffer BJ, Wang Y. Intravenous administration of bone morphogenetic protein-7 after ischemia improves motor function in stroke rats. Stroke; a Journal of Cerebral Circulation. 34: 558-64. PMID 12574575 DOI: 10.1161/01.Str.0000051507.64423.00  0.275
2000 Lein P, Gallagher PJ, Amodeo J, Howie H, Roth JA. Manganese induces neurite outgrowth in PC12 cells via upregulation of alpha(v) integrins. Brain Research. 885: 220-30. PMID 11102576 DOI: 10.1016/S0006-8993(00)02943-7  0.273
2019 Bandara SB, Carty DR, Singh V, Harvey DJ, Vasylieva N, Pressly B, Wulff H, Lein PJ. Susceptibility of larval zebrafish to the seizurogenic activity of GABA type A receptor antagonists. Neurotoxicology. PMID 31811871 DOI: 10.1016/J.Neuro.2019.12.001  0.272
2014 Stamou M, Wu X, Kania-Korwel I, Lehmler HJ, Lein PJ. Cytochrome p450 mRNA expression in the rodent brain: species-, sex-, and region-dependent differences. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 239-44. PMID 24255117 DOI: 10.1124/Dmd.113.054239  0.27
2017 Hobson BA, Rowland DJ, Supasai S, Harvey DJ, Lein PJ, Garbow JR. A magnetic resonance imaging study of early brain injury in a rat model of acute DFP intoxication. Neurotoxicology. PMID 29183789 DOI: 10.1016/J.Neuro.2017.11.009  0.269
2015 Kania-Korwel I, Barnhart CD, Lein PJ, Lehmler HJ. Effect of Pregnancy on the Disposition of 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) Atropisomers and Their Hydroxylated Metabolites in Female Mice. Chemical Research in Toxicology. 28: 1774-83. PMID 26271003 DOI: 10.1021/Acs.Chemrestox.5B00241  0.268
2019 Grodzki AC, Schelegle E, Lein P. Developmental Exposure to Chlorpyrifos Modulates Pulmonary Function in Adult Rats The Faseb Journal. 33. DOI: 10.1096/Fasebj.2019.33.1_Supplement.812.12  0.268
2020 Grodzki ACG, Kurland JS, Gorin FA, Lein PJ. Cytokines Modulate the Expression of Calcitonin‐Gene‐Related‐Peptide and Substance P in Primary Rat DRG Neuron‐glia Co‐cultures The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.09268  0.266
2017 Hobson BA, Sisó S, Rowland DJ, Harvey DJ, Bruun DA, Garbow JR, Lein PJ. Magnetic Resonance Imaging Reveals Progressive Brain Injury in Rats Acutely Intoxicated with Diisopropylfluorophosphate. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 28329842 DOI: 10.1093/Toxsci/Kfx049  0.266
1988 Kung MP, Nickerson P, Sansone FM, Olson JR, Kostyniak PJ, Adolf MA, Lein PJ, Roth JA. Effect of short-term exposure to hexachlorophene on rat brain marker enzymes Toxicological Sciences. 11: 519-527. DOI: 10.1093/Toxsci/11.1.519  0.266
2018 Berg EL, Copping NA, Rivera JK, Pride MC, Careaga M, Bauman MD, Berman RF, Lein PJ, Harony-Nicolas H, Buxbaum JD, Ellegood J, Lerch JP, Wöhr M, Silverman JL. Developmental social communication deficits in the Shank3 rat model of phelan-mcdermid syndrome and autism spectrum disorder. Autism Research : Official Journal of the International Society For Autism Research. PMID 29377611 DOI: 10.1002/Aur.1925  0.265
2013 Dadson OA, Ellison CA, Singleton ST, Chi LH, McGarrigle BP, Lein PJ, Farahat FM, Farahat T, Olson JR. Metabolism of profenofos to 4-bromo-2-chlorophenol, a specific and sensitive exposure biomarker. Toxicology. 306: 35-9. PMID 23415833 DOI: 10.1016/J.Tox.2013.01.023  0.264
2016 Flannery BM, Bruun DA, Rowland DJ, Banks CN, Austin AT, Kukis DL, Li Y, Ford BD, Tancredi DJ, Silverman JL, Cherry SR, Lein PJ. Persistent neuroinflammation and cognitive impairment in a rat model of acute diisopropylfluorophosphate intoxication. Journal of Neuroinflammation. 13: 267. PMID 27733171 DOI: 10.1186/S12974-016-0744-Y  0.261
2010 Yang D, Bruun D, Andres DA, Lein PJ. Method for Shipping Live Cultures of Dissociated Rat Hippocampal Neurons. Current Neurobiology. 1: 95-98. PMID 24052689  0.261
2024 Kim H, Le B, Goshi N, Zhu K, Grodzki AC, Lein PJ, Zhao M, Seker E. Rat primary cortical cell tri-culture to study effects of amyloid-beta on microglia function. Biorxiv : the Preprint Server For Biology. PMID 38558989 DOI: 10.1101/2024.03.15.584736  0.259
2007 Lein P, Locke P, Goldberg A. Meeting report: alternatives for developmental neurotoxicity testing. Environmental Health Perspectives. 115: 764-8. PMID 17520065 DOI: 10.1289/Ehp.9841  0.258
2018 Chen X, Walter KM, Miller GW, Lein PJ, Puschner B. Simultaneous quantification of T4, T3, rT3, 3,5-T2 and 3,3'-T2 in larval zebrafish (Danio rerio) as a model to study exposure to polychlorinated biphenyls. Biomedical Chromatography : Bmc. PMID 29314156 DOI: 10.1002/Bmc.4185  0.258
2020 Petkova SP, Pride M, Klocke C, Fenton TA, White J, Lein PJ, Ellegood J, Lerch JP, Silverman JL, Waldau B. Cyclin D2-knock-out mice with attenuated dentate gyrus neurogenesis have robust deficits in long-term memory formation. Scientific Reports. 10: 8204. PMID 32424171 DOI: 10.1038/S41598-020-65090-1  0.256
2012 Bal-Price AK, Coecke S, Costa L, Crofton KM, Fritsche E, Goldberg A, Grandjean P, Lein PJ, Li A, Lucchini R, Mundy WR, Padilla S, Persico AM, Seiler AE, Kreysa J. Advancing the science of developmental neurotoxicity (DNT): testing for better safety evaluation. Altex. 29: 202-15. PMID 22892558 DOI: 10.14573/Altex.2012.2.202  0.252
2016 Singh L, Pressly B, Mengeling BJ, Fettinger JC, Furlow JD, Lein PJ, Wulff H, Singh V. Chasing the Elusive Benzofuran Impurity of the THR Antagonist NH-3: Synthesis, Isotope Labeling and Biological Activity. The Journal of Organic Chemistry. PMID 26849160 DOI: 10.1021/Acs.Joc.5B02665  0.251
2018 Dach K, Yaghoobi B, Schmuck MR, Carty DR, Morales KM, Lein PJ. Teratological and behavioral screening of the National Toxicology Program 91-compound library in zebrafish (Danio rerio). Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 30364989 DOI: 10.1093/Toxsci/Kfy266  0.25
2007 Coecke S, Goldberg AM, Allen S, Buzanska L, Calamandrei G, Crofton K, Hareng L, Hartung T, Knaut H, Honegger P, Jacobs M, Lein P, Li A, Mundy W, Owen D, et al. Workgroup report: incorporating in vitro alternative methods for developmental neurotoxicity into international hazard and risk assessment strategies. Environmental Health Perspectives. 115: 924-31. PMID 17589601 DOI: 10.1289/Ehp.9427  0.245
2018 González EA, Carty DR, Tran FD, Cole AM, Lein PJ. Developmental Exposure to Silver Nanoparticles at Environmentally Relevant Concentrations Alters Swimming Behavior in Zebrafish (Danio rerio). Environmental Toxicology and Chemistry. PMID 30242895 DOI: 10.1002/Etc.4275  0.243
2016 Dunaway K, Goorha S, Matelski L, Urraca N, Lein PJ, Korf I, Reiter LT, LaSalle JM. Dental Pulp Stem Cells Model Early Life and Imprinted DNA Methylation Patterns. Stem Cells (Dayton, Ohio). PMID 28032673 DOI: 10.1002/Stem.2563  0.242
2016 Saldarriaga W, Lein P, González Teshima LY, Isaza C, Rosa L, Polyak A, Hagerman R, Girirajan S, Silva M, Tassone F. PHENOBARBITAL USE AND NEUROLOGICAL PROBLEMS IN FMR1 PREMUTATION CARRIERS. Neurotoxicology. PMID 26802682 DOI: 10.1016/J.Neuro.2016.01.008  0.241
2015 Wu X, Barnhart C, Lein PJ, Lehmler HJ. Hepatic metabolism affects the atropselective disposition of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) in mice. Environmental Science & Technology. 49: 616-25. PMID 25420130 DOI: 10.1021/Es504766P  0.239
2022 Goshi N, Morgan RK, Lein PJ, Seker E. Correction to: A primary neural cell culture model to study neuron, astrocyte, and microglia interactions in neuroinflammation. Journal of Neuroinflammation. 19: 49. PMID 35151333 DOI: 10.1186/s12974-022-02391-4  0.238
2014 Haudenschild DR, Eldridge A, Lein PJ, Chromy BA. High abundant protein removal from rodent blood for biomarker discovery. Biochemical and Biophysical Research Communications. 455: 84-9. PMID 25445603 DOI: 10.1016/J.Bbrc.2014.09.137  0.238
2011 Crofton KM, Mundy WR, Lein PJ, Bal-Price A, Coecke S, Seiler AE, Knaut H, Buzanska L, Goldberg A. Developmental neurotoxicity testing: recommendations for developing alternative methods for the screening and prioritization of chemicals. Altex. 28: 9-15. PMID 21311847 DOI: 10.14573/Altex.2011.1.009  0.235
2018 Hampe AE, Li Z, Sethi S, Lein PJ, Seker E. A Microfluidic Platform to Study Astrocyte Adhesion on Nanoporous Gold Thin Films. Nanomaterials (Basel, Switzerland). 8. PMID 29933551 DOI: 10.3390/Nano8070452  0.235
2017 Chapman CA, Zhu X, Chen H, Yanik AA, Lein PJ, Seker E. Nanostructure Introduces Artifacts in Quantitative Immunofluorescence by Influencing Fluorophore Intensity. Scientific Reports. 7: 427. PMID 28348397 DOI: 10.1038/S41598-017-00447-7  0.234
2012 Lein PJ. Emerging concepts in neurotoxicology: models, mechanisms and modifying factors. Neurotoxicology. 33: 516-7. PMID 22694846 DOI: 10.1016/J.Neuro.2012.04.010  0.234
2019 Karey E, Pan S, Morris AN, Bruun DA, Lein PJ, Chen CY. The Use of Percent Change in RR Interval for Data Exclusion in Analyzing 24-h Time Domain Heart Rate Variability in Rodents. Frontiers in Physiology. 10: 693. PMID 31244671 DOI: 10.3389/Fphys.2019.00693  0.233
2017 Chapman CAR, Wang L, Chen H, Garrison J, Lein PJ, Seker E. Neural Interfaces: Nanoporous Gold Biointerfaces: Modifying Nanostructure to Control Neural Cell Coverage and Enhance Electrophysiological Recording Performance (Adv. Funct. Mater. 3/2017) Advanced Functional Materials. 27. DOI: 10.1002/Adfm.201770015  0.232
2010 Yang D, Lein PJ. Polychlorinated biphenyls increase apoptosis in the developing rat brain. Current Neurobiology. 1: 70-76. PMID 24052688  0.23
2017 van Thriel C, Levin E, Lein P, Costa LG, Westerink RH. Neural mechanisms of functional impairment across the lifespan: The 15th Biennial Meeting of the International Neurotoxicology Association and 39th Annual Meeting of the Neurobehavioral Teratology Society. Neurotoxicology. 59: 131-132. PMID 28347437 DOI: 10.1016/J.Neuro.2017.03.003  0.228
2015 Barnhart CD, Yang D, Lein PJ. Using the Morris water maze to assess spatial learning and memory in weanling mice. Plos One. 10: e0124521. PMID 25886563 DOI: 10.1371/Journal.Pone.0124521  0.228
2018 Saldarriaga W, Salcedo-Arellano MJ, Rodriguez-Guerrero T, Ríos M, Fandiño-Losada A, Ramirez-Cheyne J, Lein PJ, Tassone F, Hagerman RJ. Increased Severity of Fragile X Spectrum Disorders in the Agricultural Community of Ricaurte, Colombia. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. PMID 30385191 DOI: 10.1016/J.Ijdevneu.2018.10.002  0.224
2022 Pullin AN, Farrar VS, Loxterkamp JW, Jones CT, Calisi RM, Horback K, Lein PJ, Makagon MM. Providing height to pullets does not influence hippocampal dendritic morphology or brain-derived neurotrophic factor at the end of the rearing period. Poultry Science. 101: 102161. PMID 36252500 DOI: 10.1016/j.psj.2022.102161  0.224
2012 Liu C, Li Y, Lein PJ, Ford BD. Spatiotemporal patterns of GFAP upregulation in rat brain following acute intoxication with diisopropylfluorophosphate (DFP). Current Neurobiology. 3: 90-97. PMID 24039349  0.22
2023 Biechele-Speziale D, Camarillo M, Martin NR, Biechele-Speziale J, Lein PJ, Plavicki JS. Assessing CaMPARI as new approach methodology for evaluating neurotoxicity. Neurotoxicology. PMID 37244562 DOI: 10.1016/j.neuro.2023.05.013  0.214
2021 Tsai YH, Lein PJ. Mechanisms of organophosphate neurotoxicity. Current Opinion in Toxicology. 26: 49-60. PMID 34308007 DOI: 10.1016/j.cotox.2021.04.002  0.21
2012 Ellison CA, Abou El-Ella SS, Tawfik M, Lein PJ, Olson JR. Allele and genotype frequencies of CYP2B6 and CYP2C19 polymorphisms in Egyptian agricultural workers. Journal of Toxicology and Environmental Health. Part A. 75: 232-41. PMID 22352331 DOI: 10.1080/15287394.2012.641201  0.21
1987 Pancorbo OC, Lein PJ, Blevins RD. Mutagenic activity of surface waters adjacent to a nuclear fuel processing facility. Archives of Environmental Contamination and Toxicology. 16: 531-7. PMID 3632040 DOI: 10.1007/Bf01055809  0.209
2021 Keil Stietz KP, Kennedy CL, Sethi S, Valenzuela A, Nunez A, Wang K, Wang Z, Wang P, Spiegelhoff A, Puschner B, Bjorling DE, Lein PJ. In utero and lactational PCB exposure drives anatomic changes in the juvenile mouse bladder. Current Research in Toxicology. 2: 1-18. PMID 34337439 DOI: 10.1016/j.crtox.2021.01.002  0.208
2019 Doorn J, Lein P. Editorial: Influence of the Microbiome on Neurotoxic Outcomes. Neurotoxicology. PMID 31811870 DOI: 10.1016/J.Neuro.2019.12.002  0.205
2019 Patten KT, Lein PJ. Gene-environment interactions determine risk for dementia: the influence of lifestyle on genetic risk for dementia. Annals of Translational Medicine. 7: S322. PMID 32016040 DOI: 10.21037/Atm.2019.09.155  0.2
2021 Walter KM, Singh L, Singh V, Lein PJ. Investigation of NH3 as a selective thyroid hormone receptor modulator in larval zebrafish (Danio rerio). Neurotoxicology. PMID 33745965 DOI: 10.1016/j.neuro.2021.03.003  0.191
2021 vonderEmbse AN, Elmore SE, Jackson KB, Habecker BA, Manz KE, Pennell KD, Lein PJ, La Merrill MA. Developmental exposure to DDT or DDE alters sympathetic innervation of brown adipose in adult female mice. Environmental Health : a Global Access Science Source. 20: 37. PMID 33794904 DOI: 10.1186/s12940-021-00721-2  0.184
2023 Bernardino PN, Hobson BA, Huddleston SL, Andrew PM, MacMahon JA, Saito NH, Porter VA, Bruun DA, Harvey DJ, Garbow JR, Gelli A, Chaudhari AJ, Lein PJ. Time- and region-dependent blood-brain barrier impairment in a rat model of organophosphate-induced status epilepticus. Neurobiology of Disease. 187: 106316. PMID 37797902 DOI: 10.1016/j.nbd.2023.106316  0.181
2021 Calsbeek JJ, González EA, Bruun DA, Guignet MA, Copping N, Dawson ME, Yu AJ, MacMahon JA, Saito NH, Harvey DJ, Silverman JL, Lein PJ. Persistent neuropathology and behavioral deficits in a mouse model of status epilepticus induced by acute intoxication with diisopropylfluorophosphate. Neurotoxicology. PMID 34509511 DOI: 10.1016/j.neuro.2021.09.001  0.175
2020 Matelski L, Keil Stietz KP, Sethi S, Taylor SL, Van de Water J, Lein PJ. The influence of sex, genotype, and dose on serum and hippocampal cytokine levels in juvenile mice developmentally exposed to a human-relevant mixture of polychlorinated biphenyls. Current Research in Toxicology. 1: 85-103. PMID 34296199 DOI: 10.1016/j.crtox.2020.09.001  0.168
2022 Laufer BI, Neier K, Valenzuela AE, Yasui DH, Schmidt RJ, Lein PJ, LaSalle JM. Placenta and fetal brain share a neurodevelopmental disorder DNA methylation profile in a mouse model of prenatal PCB exposure. Cell Reports. 38: 110442. PMID 35235788 DOI: 10.1016/j.celrep.2022.110442  0.167
2021 González EA, Calsbeek JJ, Tsai YH, Tang MY, Andrew P, Vu J, Berg EL, Saito NH, Harvey DJ, Supasai S, Gurkoff GG, Silverman JL, Lein PJ. Sex-specific acute and chronic neurotoxicity of acute diisopropylfluorophosphate (DFP)-intoxication in juvenile Sprague-Dawley rats. Current Research in Toxicology. 2: 341-356. PMID 34622217 DOI: 10.1016/j.crtox.2021.09.002  0.165
2022 Mundy PC, Mendieta R, Lein PJ. Diisopropylfluorophosphate (DFP) volatizes and cross-contaminates wells in a common 96-well plate format used in zebrafish larvae toxicology studies. Journal of Pharmacological and Toxicological Methods. 115: 107173. PMID 35545188 DOI: 10.1016/j.vascn.2022.107173  0.164
2020 Perng V, Li C, Navazesh S, Klocke C, Pinneles D, Lein P, Ji P. Iron Deficiency and Iron Excess Alter Dendritic Architecture of Pyramidal Neurons in the Hippocampus of Neonatal Pigs Current Developments in Nutrition. 4: 1232-1232. DOI: 10.1093/cdn/nzaa057_048  0.164
2021 Toedebusch R, Grodzki AC, Dickinson PJ, Woolard K, Vinson N, Sturges B, Snyder J, Li CF, Nagasaka O, Consales B, Vernau K, Knipe M, Murthy V, Lein PJ, Toedebusch CM. Glioma-associated microglia/macrophages augment tumorigenicity in canine astrocytoma, a naturally occurring model of human glioma. Neuro-Oncology Advances. 3: vdab062. PMID 34131649 DOI: 10.1093/noajnl/vdab062  0.153
2012 Harry GJ, Lein PJ. Developmental Neurotoxicity of Dioxins Dioxins and Health: Including Other Persistent Organic Pollutants and Endocrine Disruptors: Third Edition. 193-227. DOI: 10.1002/9781118184141.ch7  0.152
2022 Goshi N, Girardi G, da Costa Souza F, Gardner A, Lein PJ, Seker E. Influence of microchannel geometry on device performance and electrophysiological recording fidelity during long-term studies of connected neural populations. Lab On a Chip. PMID 36111641 DOI: 10.1039/d2lc00683a  0.151
2019 Stamou M, Lein PJ. Commentary: Fc Gamma Receptors are Expressed in the Developing Rat Brain and Activate Downstream Signaling Molecules upon Cross-Linking with Immune Complex. Journal of Neurology & Neuromedicine. 4: 26-29. PMID 31131371 DOI: 10.29245/2572.942X/2019/1.1243  0.151
2024 Pan S, Bruun DA, Lein PJ, Chen CY. Cardiovascular responses of adult male Sprague-Dawley rats following acute organophosphate intoxication and post-exposure treatment with midazolam with or without allopregnanolone. Archives of Toxicology. PMID 38305864 DOI: 10.1007/s00204-023-03679-x  0.15
2020 Cameron LP, Tombari RJ, Lu J, Pell AJ, Hurley ZQ, Ehinger Y, Vargas MV, McCarroll MN, Taylor JC, Myers-Turnbull D, Liu T, Yaghoobi B, Laskowski LJ, Anderson EI, Zhang G, ... ... Lein PJ, et al. A non-hallucinogenic psychedelic analogue with therapeutic potential. Nature. PMID 33299186 DOI: 10.1038/s41586-020-3008-z  0.15
2021 Calsbeek JJ, González EA, Boosalis CA, Zolkowska D, Bruun DA, Rowland DJ, Saito NH, Harvey DJ, Chaudhari AJ, Rogawski MA, Garbow JR, Lein PJ. Strain differences in the extent of brain injury in mice after tetramethylenedisulfotetramine-induced status epilepticus. Neurotoxicology. PMID 34478772 DOI: 10.1016/j.neuro.2021.08.011  0.147
2022 Liang N, Emami S, Patten KT, Valenzuela AE, Wallis CD, Wexler AS, Bein KJ, Lein PJ, Taha AY. Chronic exposure to traffic-related air pollution reduces lipid mediators of linoleic acid and soluble epoxide hydrolase in serum of female rats. Environmental Toxicology and Pharmacology. 103875. PMID 35550873 DOI: 10.1016/j.etap.2022.103875  0.145
2023 Tombari RJ, Mundy PC, Morales KM, Dunlap LE, Olson DE, Lein PJ. Developmental Neurotoxicity Screen of Psychedelics and Other Drugs of Abuse in Larval Zebrafish (). Acs Chemical Neuroscience. PMID 36753397 DOI: 10.1021/acschemneuro.2c00642  0.141
2023 Bernardino PN, Luo AS, Andrew PM, Unkel CM, Gonzalez MI, Gelli A, Lein PJ. . The Journal of Pharmacology and Experimental Therapeutics. PMID 37827702 DOI: 10.1124/jpet.123.001836  0.139
2022 Bein KJ, Wallis CD, Silverman JL, Lein PJ, Wexler AS. Emulating Near-Roadway Exposure to Traffic-Related Air Pollution via Real-Time Emissions from a Major Freeway Tunnel System. Environmental Science & Technology. PMID 35235290 DOI: 10.1021/acs.est.1c07047  0.134
2022 Patten KT, Valenzuela AE, Wallis C, Harvey DJ, Bein KJ, Wexler AS, Gorin FA, Lein PJ. Hippocampal but Not Serum Cytokine Levels Are Altered by Traffic-Related Air Pollution in TgF344-AD and Wildtype Fischer 344 Rats in a Sex- and Age-Dependent Manner. Frontiers in Cellular Neuroscience. 16: 861733. PMID 35530180 DOI: 10.3389/fncel.2022.861733  0.132
2022 Carlson LM, Christensen K, Sagiv SK, Rajan P, Klocke CR, Lein PJ, Coffman E, Shaffer RM, Yost EE, Arzuaga X, Factor-Litvak P, Sergeev A, Toborek M, Bloom MS, Trgovcich J, et al. A systematic evidence map for the evaluation of noncancer health effects and exposures to polychlorinated biphenyl mixtures. Environmental Research. 115148. PMID 36580985 DOI: 10.1016/j.envres.2022.115148  0.132
2021 Zhang CY, Klocke CR, Lein PJ, Lehmler HJ. Disposition of PCB 11 in Mice Following Acute Oral Exposure. Chemical Research in Toxicology. PMID 33734669 DOI: 10.1021/acs.chemrestox.1c00067  0.132
2022 Keil-Stietz K, Lein PJ. Gene×environment interactions in autism spectrum disorders. Current Topics in Developmental Biology. 152: 221-284. PMID 36707213 DOI: 10.1016/bs.ctdb.2022.11.001  0.127
2020 Perng V, Li C, Klocke CR, Navazesh SE, Pinneles DK, Lein PJ, Ji P. Iron Deficiency and Iron Excess Differently Affect Dendritic Architecture of Pyramidal Neurons in the Hippocampus of Piglets. The Journal of Nutrition. PMID 33245133 DOI: 10.1093/jn/nxaa326  0.126
2022 Shen Q, Patten KT, Valenzuela A, Lein PJ, Taha AY. Probing changes in brain esterified oxylipin concentrations during the early stages of pathogenesis in Alzheimer's Disease transgenic rats. Neuroscience Letters. 136921. PMID 36270451 DOI: 10.1016/j.neulet.2022.136921  0.125
2021 Andrew PM, Lein PJ. Neuroinflammation as a Therapeutic Target for Mitigating the Long-Term Consequences of Acute Organophosphate Intoxication. Frontiers in Pharmacology. 12: 674325. PMID 34054549 DOI: 10.3389/fphar.2021.674325  0.125
2023 Mouat JS, Li X, Neier K, Zhu Y, Mordaunt CE, La Merrill MA, Lehmler HJ, Jones MP, Lein PJ, Schmidt RJ, LaSalle JM. Networks of placental DNA methylation correlate with maternal serum PCB concentrations and child neurodevelopment. Environmental Research. 220: 115227. PMID 36608759 DOI: 10.1016/j.envres.2023.115227  0.125
2024 Hobson BA, Rowland DR, Dou Y, Saito N, Harmany ZT, Bruun DA, Harvey DJ, Chaudhari A, Garbow JR, Lein PJ. A longitudinal MRI and TSPO PET-based investigation of brain region-specific neuroprotection by diazepam versus midazolam following organophosphate-induced seizures. Neuropharmacology. 109918. PMID 38527652 DOI: 10.1016/j.neuropharm.2024.109918  0.124
2021 Mundy PC, Pressly B, Carty DR, Yaghoobi B, Wulff H, Lein PJ. The efficacy of γ-aminobutyric acid type A receptor (GABA R) subtype-selective positive allosteric modulators in blocking tetramethylenedisulfotetramine (TETS)-induced seizure-like behavior in larval zebrafish with minimal sedation. Toxicology and Applied Pharmacology. 115643. PMID 34265354 DOI: 10.1016/j.taap.2021.115643  0.124
2020 Matelski L, Keil Stietz KP, Sethi S, Taylor SL, Van de Water J, Lein PJ. The influence of sex, genotype, and dose on serum and hippocampal cytokine levels in juvenile mice developmentally exposed to a human-relevant mixture of polychlorinated biphenyls Current Research in Toxicology. 1: 85-103. DOI: 10.1016/j.crtox.2020.09.001  0.123
2023 Mundy PC, Werner A, Singh L, Singh V, Mendieta R, Patullo CE, Wulff H, Lein PJ. Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) causes seizure activity in larval zebrafish via antagonism of γ-aminobutyric acid type A receptor α1β2γ2. Archives of Toxicology. PMID 36912926 DOI: 10.1007/s00204-023-03475-7  0.123
2020 Edwards S, Zhao G, Tran J, Patten KT, Valenzuela A, Wallis C, Bein KJ, Wexler AS, Lein PJ, Rao X. Pathological Cardiopulmonary Evaluation of Rats Chronically Exposed to Traffic-Related Air Pollution. Environmental Health Perspectives. 128: 127003. PMID 33275451 DOI: 10.1289/EHP7045  0.121
2020 Colón-Rodríguez A, Uribe-Salazar JM, Weyenberg KB, Sriram A, Quezada A, Kaya G, Jao E, Radke B, Lein PJ, Dennis MY. Assessment of Autism Zebrafish Mutant Models Using a High-Throughput Larval Phenotyping Platform. Frontiers in Cell and Developmental Biology. 8: 586296. PMID 33330465 DOI: 10.3389/fcell.2020.586296  0.12
2024 Almeida AJD, Hobson BA, Saito N, Bruun DA, Porter VA, Harvey DJ, Garbow JR, Chaudhari AJ, Lein PJ. Quantitative T mapping-based longitudinal assessment of brain injury and therapeutic rescue in the rat following acute organophosphate intoxication. Neuropharmacology. 109895. PMID 38437913 DOI: 10.1016/j.neuropharm.2024.109895  0.118
2020 Berg EL, Ching TM, Bruun DA, Rivera JK, Careaga M, Ellegood J, Lerch JP, Wöhr M, Lein PJ, Silverman JL. Translational outcomes relevant to neurodevelopmental disorders following early life exposure of rats to chlorpyrifos. Journal of Neurodevelopmental Disorders. 12: 40. PMID 33327943 DOI: 10.1186/s11689-020-09342-1  0.114
2023 Sandoval S, Malany K, Thongphanh K, Martinez CA, Goodson ML, Souza FDC, Lin LW, Sweeney N, Pennington J, Lein PJ, Kerkvliet NI, Ehrlich AK. Activation of the aryl hydrocarbon receptor inhibits neuropilin-1 upregulation on IL-2-responding CD4 T cells. Frontiers in Immunology. 14: 1193535. PMID 38035105 DOI: 10.3389/fimmu.2023.1193535  0.113
2021 Patten KT, Valenzuela AE, Wallis C, Berg EL, Silverman JL, Bein KJ, Wexler AS, Lein PJ. The Effects of Chronic Exposure to Ambient Traffic-Related Air Pollution on Alzheimer's Disease Phenotypes in Wildtype and Genetically Predisposed Male and Female Rats. Environmental Health Perspectives. 129: 57005. PMID 33971107 DOI: 10.1289/EHP8905  0.112
2023 Sandoval S, Malany K, Thongphanh K, Martinez CA, Goodson ML, Souza FDC, Lin LW, Pennington J, Lein PJ, Kerkvliet NI, Ehrlich AK. Activation of the aryl hydrocarbon receptor inhibits neuropilin-1 upregulation on IL-2 responding CD4 T cells. Biorxiv : the Preprint Server For Biology. PMID 37808764 DOI: 10.1101/2023.09.25.559429  0.106
2020 Zhang Z, Emami S, Hennebelle M, Morgan RK, Lerno LA, Slupsky CM, Lein PJ, Taha AY. Linoleic acid-derived 13-hydroxyoctadecadienoic acid is absorbed and incorporated into rat tissues. Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. 158870. PMID 33340768 DOI: 10.1016/j.bbalip.2020.158870  0.104
2023 Guignet M, Schmuck M, Harvey DJ, Nguyen D, Bruun D, Echeverri A, Gurkoff G, Lein PJ. Novel image analysis tool for rapid screening of cell morphology in preclinical animal models of disease. Heliyon. 9: e13449. PMID 36873154 DOI: 10.1016/j.heliyon.2023.e13449  0.103
2006 Jett DA, Lein PJ. Noncholinesterase mechanisms of central and peripheral neurotoxicity: Muscarinic receptors and other targets Toxicology of Organophosphate & Carbamate Compounds. 233-245. DOI: 10.1016/B978-012088523-7/50018-1  0.102
2022 Tang MY, Gorin FA, Lein PJ. Review of evidence implicating the plasminogen activator system in blood-brain barrier dysfunction associated with Alzheimer's disease. Ageing and Neurodegenerative Diseases. 2. PMID 35156107 DOI: 10.20517/and.2022.05  0.1
2021 Dou Y, Tsai YH, Liu CC, Hobson BA, Lein PJ. Co-localization of fluorescent signals using deep learning with Manders overlapping coefficient. Proceedings of Spie--the International Society For Optical Engineering. 11596. PMID 34305257 DOI: 10.1117/12.2580650  0.099
2022 Thessen AE, Marvel S, Achenbach JC, Fischer S, Haendel MA, Hayward K, Klüver N, Könemann S, Legradi J, Lein P, Leong C, Mylroie JE, Padilla S, Perone D, Planchart A, et al. Implementation of Zebrafish Ontologies for Toxicology Screening. Frontiers in Toxicology. 4: 817999. PMID 35387429 DOI: 10.3389/ftox.2022.817999  0.096
2022 Dutta M, Weigel KM, Patten KT, Valenzuela AE, Wallis C, Bein KJ, Wexler AS, Lein PJ, Cui JY. Chronic exposure to ambient traffic-related air pollution (TRAP) alters gut microbial abundance and bile acid metabolism in a transgenic rat model of Alzheimer's disease. Toxicology Reports. 9: 432-444. PMID 35310146 DOI: 10.1016/j.toxrep.2022.03.003  0.092
2024 Reuter MA, Tucker M, Marfori Z, Shishani R, Bustamante JM, Moreno R, Goodson ML, Ehrlich A, Taha AY, Lein PJ, Joshi N, Brito I, Durbin-Johnson B, Nandakumar R, Cummings BP. Dietary resistant starch supplementation increases gut luminal deoxycholic acid abundance in mice. Gut Microbes. 16: 2315632. PMID 38375831 DOI: 10.1080/19490976.2024.2315632  0.088
2023 Lavezzi AM, Colizzi M, Lein PJ. Editorial: Advances in understanding the pathogenetic mechanisms of neurodevelopmental disorders and neurodegenerative disease - The environment as a putative risk factor. Frontiers in Neurology. 14: 1259772. PMID 37602235 DOI: 10.3389/fneur.2023.1259772  0.081
2015 Lein PJ. Overview of the Role of Environmental Factors in Neurodevelopmental Disorders Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders. 3-20. DOI: 10.1016/B978-0-12-800228-5.00001-7  0.079
2023 Bruun DA, Ma B, Chen YJ, Wu CY, Aleman M, Zolkowska D, Smiley-Jewell SM, Rogawski MA, Lein PJ. Tolerability and pharmacokinetics of intravenous allopregnanolone with and without midazolam pretreatment in two healthy dogs. Epilepsia Open. PMID 36919379 DOI: 10.1002/epi4.12723  0.076
2024 Rutkowsky JM, Roland Z, Valenzuela A, Nguyen AB, Park HH, Six N, Dursun I, Kim K, Lein PJ, Ramsey JJ. The impact of continuous and intermittent ketogenic diets on cognitive behavior, motor function, and blood lipids in TgF344-AD rats. Aging. 16. PMID 38613791 DOI: 10.18632/aging.205741  0.075
2013 Mooney SM, Lein PJ, Miller MW. Fetal Alcohol Spectrum Disorder: Targeted Effects of Ethanol on Cell Proliferation and Survival Neural Circuit Development and Function in the Heathy and Diseased Brain. 521-537. DOI: 10.1016/B978-0-12-397267-5.00139-4  0.073
2014 Levoe SN, Flannery BM, Brignolo L, Imai DM, Koehne A, Austin AT, Bruun DA, Tancredi DJ, Lein PJ. Factors influencing adverse skin responses in rats receiving repeated subcutaneous injections and potential impact on neurobehavior. Current Neurobiology. 5: 1-10. PMID 25705100  0.073
2022 Dyall SC, Balas L, Bazan NG, Brenna JT, Chiang N, da Costa Souza F, Dalli J, Durand T, Galano JM, Lein PJ, Serhan CN, Taha AY. Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions. Progress in Lipid Research. 86: 101165. PMID 35508275 DOI: 10.1016/j.plipres.2022.101165  0.072
2024 Porter VA, Hobson BA, Foster B, Lein PJ, Chaudhari AJ. Fully automated whole brain segmentation from rat MRI scans with a convolutional neural network. Journal of Neuroscience Methods. 405: 110078. PMID 38340902 DOI: 10.1016/j.jneumeth.2024.110078  0.07
2022 Zhang CY, Li X, Keil Stietz KP, Sethi S, Yang W, Marek RF, Ding X, Lein PJ, Hornbuckle KC, Lehmler HJ. Machine Learning-Assisted Identification and Quantification of Hydroxylated Metabolites of Polychlorinated Biphenyls in Animal Samples. Environmental Science & Technology. PMID 36047920 DOI: 10.1021/acs.est.2c02027  0.063
2023 Zhang CY, Li X, Keil Stietz KP, Sethi S, Yang W, Marek RF, Ding X, Lein PJ, Hornbuckle KC, Lehmler HJ. Rebuttal to Correspondence on "Machine Learning-Assisted Identification and Quantification of Hydroxylated Metabolites of Polychlorinated Biphenyls in Animal Samples". Environmental Science & Technology. PMID 37017328 DOI: 10.1021/acs.est.3c01659  0.036
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