John Blenis - Publications

Affiliations: 
Harvard Medical School, Boston, MA, United States 
Area:
Cell biology

201 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Samson SC, Elliott A, Mueller BD, Kim Y, Carney KR, Bergman JP, Blenis J, Mendoza MC. p90 ribosomal S6 kinase (RSK) phosphorylates myosin phosphatase and thereby controls edge dynamics during cell migration. The Journal of Biological Chemistry. PMID 31138649 DOI: 10.1074/jbc.RA119.007431  0.56
2019 Liu P, Gan W, Inuzuka H, Lazorchak AS, Gao D, Arojo O, Liu D, Wan L, Zhai B, Yu Y, Yuan M, Kim BM, Shaik S, Menon S, Gygi SP, ... ... Blenis J, et al. Author Correction: Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. Nature Cell Biology. PMID 30783264 DOI: 10.1038/s41556-019-0280-y  0.44
2019 Shin S, Buel GR, Nagiec MJ, Han MJ, Roux PP, Blenis J, Yoon SO. ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation. Proceedings of the National Academy of Sciences of the United States of America. PMID 30728292 DOI: 10.1073/pnas.1811923116  0.88
2018 Zheng Y, Lin TY, Lee G, Paddock MN, Momb J, Cheng Z, Li Q, Fei DL, Stein BD, Ramsamooj S, Zhang G, Blenis J, Cantley LC. Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells. Cell. 175: 1546-1560.e17. PMID 30500537 DOI: 10.1016/j.cell.2018.09.041  0.36
2018 He L, Gomes AP, Wang X, Yoon SO, Lee G, Nagiec MJ, Cho S, Chavez A, Islam T, Yu Y, Asara JM, Kim BY, Blenis J. mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation. Molecular Cell. PMID 29861159 DOI: 10.1016/j.molcel.2018.04.024  0.52
2017 Lee G, Zheng Y, Cho S, Jang C, England C, Dempsey JM, Yu Y, Liu X, He L, Cavaliere PM, Chavez A, Zhang E, Isik M, Couvillon A, Dephoure NE, ... ... Blenis J, et al. Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling. Cell. PMID 29153836 DOI: 10.1016/j.cell.2017.10.037  0.52
2017 Yoon SO, Shin S, Karreth FA, Buel GR, Jedrychowski MP, Plas DR, Dedhar S, Gygi SP, Roux PP, Dephoure N, Blenis J. Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition. Molecular Cell. PMID 28757207 DOI: 10.1016/j.molcel.2017.06.033  0.88
2016 Wada S, Neinast M, Jang C, Ibrahim YH, Lee G, Babu A, Li J, Hoshino A, Rowe GC, Rhee J, Martina JA, Puertollano R, Blenis J, Morley M, Baur JA, et al. The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue. Genes & Development. PMID 27913603 DOI: 10.1101/gad.287953.116  0.52
2016 Li C, Li N, Liu X, Zhang EY, Sun Y, Masuda K, Li J, Sun J, Morrison T, Li X, Chen Y, Wang J, Karim NA, Zhang Y, Blenis J, et al. Proapoptotic protein Bim attenuates estrogen-enhanced survival in lymphangioleiomyomatosis. Jci Insight. 1: e86629. PMID 27882343 DOI: 10.1172/jci.insight.86629  0.56
2016 Li J, Shin S, Sun Y, Yoon SO, Li C, Zhang E, Yu J, Zhang J, Blenis J. mTORC1-driven tumor cells are highly sensitive to therapeutic targeting by antagonists of oxidative stress. Cancer Research. PMID 27197195 DOI: 10.1158/0008-5472.CAN-15-2629  1
2016 Mullarky E, Lucki NC, Beheshti Zavareh R, Anglin JL, Gomes AP, Nicolay BN, Wong JC, Christen S, Takahashi H, Singh PK, Blenis J, Warren JD, Fendt SM, Asara JM, DeNicola GM, et al. Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers. Proceedings of the National Academy of Sciences of the United States of America. PMID 26831078 DOI: 10.1073/pnas.1521548113  0.36
2016 Buel GR, Blenis J. CELL SIGNALING. Seeing mTORC1 specificity. Science (New York, N.Y.). 351: 25-6. PMID 26721988 DOI: 10.1126/science.aad9696  1
2015 Liu P, Gan W, Chin YR, Ogura K, Guo J, Zhang J, Wang B, Blenis J, Cantley LC, Toker A, Su B, Wei W. PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex. Cancer Discovery. 5: 1194-209. PMID 26293922 DOI: 10.1158/2159-8290.CD-15-0460  0.52
2015 Shin S, Buel GR, Wolgamott L, Plas DR, Asara JM, Blenis J, Yoon SO. ERK2 Mediates Metabolic Stress Response to Regulate Cell Fate. Molecular Cell. 59: 382-98. PMID 26190261 DOI: 10.1016/j.molcel.2015.06.020  1
2015 Mendoza MC, Vilela M, Juarez JE, Blenis J, Danuser G. ERK reinforces actin polymerization to power persistent edge protrusion during motility. Science Signaling. 8: ra47. PMID 25990957 DOI: 10.1126/scisignal.aaa8859  1
2015 Gomes AP, Blenis J. A nexus for cellular homeostasis: the interplay between metabolic and signal transduction pathways. Current Opinion in Biotechnology. 34: 110-117. PMID 25562138 DOI: 10.1016/j.copbio.2014.12.007  1
2015 Li J, Csibi A, Yang S, Hoffman GR, Li C, Zhang E, Yu JJ, Blenis J. Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells. Proceedings of the National Academy of Sciences of the United States of America. 112: E21-9. PMID 25524627 DOI: 10.1073/pnas.1417015112  1
2014 Csibi A, Lee G, Yoon SO, Tong H, Ilter D, Elia I, Fendt SM, Roberts TM, Blenis J. The mTORC1/S6K1 pathway regulates glutamine metabolism through the eIF4B-dependent control of c-Myc translation. Current Biology : Cb. 24: 2274-80. PMID 25220053 DOI: 10.1016/j.cub.2014.08.007  1
2014 Dunlop EA, Seifan S, Claessens T, Behrends C, Kamps MA, Rozycka E, Kemp AJ, Nookala RK, Blenis J, Coull BJ, Murray JT, van Steensel MA, Wilkinson S, Tee AR. FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation. Autophagy. 10: 1749-60. PMID 25126726 DOI: 10.4161/auto.29640  1
2014 Galan JA, Geraghty KM, Lavoie G, Kanshin E, Tcherkezian J, Calabrese V, Jeschke GR, Turk BE, Ballif BA, Blenis J, Thibault P, Roux PP. Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3. Proceedings of the National Academy of Sciences of the United States of America. 111: E2918-27. PMID 25002506 DOI: 10.1073/pnas.1405601111  1
2014 Sun Y, Gu X, Zhang E, Park MA, Pereira AM, Wang S, Morrison T, Li C, Blenis J, Gerbaudo VH, Henske EP, Yu JJ. Estradiol promotes pentose phosphate pathway addiction and cell survival via reactivation of Akt in mTORC1 hyperactive cells. Cell Death & Disease. 5: e1231. PMID 24832603 DOI: 10.1038/cddis.2014.204  1
2014 Yi T, Zhai B, Yu Y, Kiyotsugu Y, Raschle T, Etzkorn M, Seo HC, Nagiec M, Luna RE, Reinherz EL, Blenis J, Gygi SP, Wagner G. Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells. Proceedings of the National Academy of Sciences of the United States of America. 111: E2182-90. PMID 24782546 DOI: 10.1073/pnas.1404943111  1
2014 Liu M, Bai J, He S, Villarreal R, Hu D, Zhang C, Yang X, Liang H, Slaga TJ, Yu Y, Zhou Z, Blenis J, Scherer PE, Dong LQ, Liu F. Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1. Cell Metabolism. 19: 967-80. PMID 24746805 DOI: 10.1016/j.cmet.2014.03.018  1
2014 Lee G, Blenis J. Akt-ivation of RNA splicing. Molecular Cell. 53: 519-20. PMID 24560271 DOI: 10.1016/j.molcel.2014.02.010  1
2014 Li J, Kim SG, Blenis J. Rapamycin: one drug, many effects. Cell Metabolism. 19: 373-9. PMID 24508508 DOI: 10.1016/j.cmet.2014.01.001  1
2014 Li C, Lee PS, Sun Y, Gu X, Zhang E, Guo Y, Wu CL, Auricchio N, Priolo C, Li J, Csibi A, Parkhitko A, Morrison T, Planaguma A, Kazani S, ... ... Blenis J, et al. Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells. The Journal of Experimental Medicine. 211: 15-28. PMID 24395886 DOI: 10.1084/jem.20131080  1
2014 Yi T, Zhai B, Yu Y, Kiyotsugu Y, Raschle T, Etzkorn M, Seo HC, Nagiec M, Luna RE, Reinherz EL, Blenis J, Gygi SP, Wagner G. Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells (Proceedings of the National Academy of Sciences of the United States of America (2014) 111 (E2182-E2190) DOI: 10.1073/pnas.1404943111) Proceedings of the National Academy of Sciences of the United States of America. 111: 11223. DOI: 10.1073/pnas.1411381111  1
2013 Liu P, Gan W, Inuzuka H, Lazorchak AS, Gao D, Arojo O, Liu D, Wan L, Zhai B, Yu Y, Yuan M, Kim BM, Shaik S, Menon S, Gygi SP, ... ... Blenis J, et al. Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. Nature Cell Biology. 15: 1340-50. PMID 24161930 DOI: 10.1038/ncb2860  1
2013 Gu X, Yu JJ, Ilter D, Blenis N, Henske EP, Blenis J. Integration of mTOR and estrogen-ERK2 signaling in lymphangioleiomyomatosis pathogenesis. Proceedings of the National Academy of Sciences of the United States of America. 110: 14960-5. PMID 23983265 DOI: 10.1073/pnas.1309110110  1
2013 Er EE, Mendoza MC, Mackey AM, Rameh LE, Blenis J. AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyve. Science Signaling. 6: ra45. PMID 23757022 DOI: 10.1126/scisignal.2004015  1
2013 Kim SG, Buel GR, Blenis J. Nutrient regulation of the mTOR complex 1 signaling pathway. Molecules and Cells. 35: 463-73. PMID 23694989 DOI: 10.1007/s10059-013-0138-2  1
2013 Fendt SM, Bell EL, Keibler MA, Davidson SM, Wirth GJ, Fiske B, Mayers JR, Schwab M, Bellinger G, Csibi A, Patnaik A, Blouin MJ, Cantley LC, Guarente L, Blenis J, et al. Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism. Cancer Research. 73: 4429-38. PMID 23687346 DOI: 10.1158/0008-5472.CAN-13-0080  1
2013 Csibi A, Fendt SM, Li C, Poulogiannis G, Choo AY, Chapski DJ, Jeong SM, Dempsey JM, Parkhitko A, Morrison T, Henske EP, Haigis MC, Cantley LC, Stephanopoulos G, Yu J, ... Blenis J, et al. The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. Cell. 153: 840-54. PMID 23663782 DOI: 10.1016/j.cell.2013.04.023  1
2013 Buel GR, Kim SG, Blenis J. mTORC1 signaling aids in CADalyzing pyrimidine biosynthesis. Cell Metabolism. 17: 633-5. PMID 23663734 DOI: 10.1016/j.cmet.2013.04.018  1
2013 Jeong SM, Xiao C, Finley LW, Lahusen T, Souza AL, Pierce K, Li YH, Wang X, Laurent G, German NJ, Xu X, Li C, Wang RH, Lee J, Csibi A, ... ... Blenis J, et al. SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. Cancer Cell. 23: 450-63. PMID 23562301 DOI: 10.1016/j.ccr.2013.02.024  1
2013 Kim SG, Hoffman GR, Poulogiannis G, Buel GR, Jang YJ, Lee KW, Kim BY, Erikson RL, Cantley LC, Choo AY, Blenis J. Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex. Molecular Cell. 49: 172-85. PMID 23142078 DOI: 10.1016/j.molcel.2012.10.003  1
2012 Csibi A, Blenis J. Hippo-YAP and mTOR pathways collaborate to regulate organ size. Nature Cell Biology. 14: 1244-5. PMID 23196842 DOI: 10.1038/ncb2634  1
2012 Anjum R, Pae E, Blenis J, Ballif BA. TPCK inhibits AGC kinases by direct activation loop adduction at phenylalanine-directed cysteine residues. Febs Letters. 586: 3471-6. PMID 22967899 DOI: 10.1016/j.febslet.2012.07.075  1
2012 Zhang W, Mendoza MC, Pei X, Ilter D, Mahoney SJ, Zhang Y, Ma D, Blenis J, Wang Y. Down-regulation of CMTM8 induces epithelial-to-mesenchymal transition-like changes via c-MET/extracellular signal-regulated kinase (ERK) signaling. The Journal of Biological Chemistry. 287: 11850-8. PMID 22337876 DOI: 10.1074/jbc.M111.258236  1
2011 Shin S, Wolgamott L, Yu Y, Blenis J, Yoon SO. Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferation. Proceedings of the National Academy of Sciences of the United States of America. 108: E1204-13. PMID 22065737 DOI: 10.1073/pnas.1110195108  1
2011 Csibi A, Blenis J. Appetite for destruction: the inhibition of glycolysis as a therapy for tuberous sclerosis complex-related tumors. Bmc Biology. 9: 69. PMID 22018140 DOI: 10.1186/1741-7007-9-69  1
2011 Yu Y, Yoon SO, Poulogiannis G, Yang Q, Ma XM, Villén J, Kubica N, Hoffman GR, Cantley LC, Gygi SP, Blenis J. Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science (New York, N.Y.). 332: 1322-6. PMID 21659605 DOI: 10.1126/science.1199484  1
2011 Mendoza MC, Er EE, Blenis J. The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation. Trends in Biochemical Sciences. 36: 320-8. PMID 21531565 DOI: 10.1016/j.tibs.2011.03.006  1
2011 Mendoza MC, Er EE, Zhang W, Ballif BA, Elliott HL, Danuser G, Blenis J. ERK-MAPK drives lamellipodia protrusion by activating the WAVE2 regulatory complex. Molecular Cell. 41: 661-71. PMID 21419341 DOI: 10.1016/j.molcel.2011.02.031  1
2010 Kim SG, Choo AY, Blenis J. ATM: Promoter of metabolic "cost" reduction and "savings" usage during hypoxia through mTORC1 regulation. Molecular Cell. 40: 501-2. PMID 21095578 DOI: 10.1016/j.molcel.2010.11.013  1
2010 Mendoza MC, Er EE, Blenis J. ERK-MAP Kinase signaling in the cytoplasm. Methods in Molecular Biology (Clifton, N.J.). 661: 185-203. PMID 20811984 DOI: 10.1007/978-1-60761-795-2_11  1
2010 Lipinski MM, Hoffman G, Ng A, Zhou W, Py BF, Hsu E, Liu X, Eisenberg J, Liu J, Blenis J, Xavier RJ, Yuan J. A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions. Developmental Cell. 18: 1041-52. PMID 20627085 DOI: 10.1016/j.devcel.2010.05.005  1
2010 Shin S, Blenis J. ERK2/Fra1/ZEB pathway induces epithelial-to-mesenchymal transition. Cell Cycle (Georgetown, Tex.). 9: 2483-4. PMID 20543576 DOI: 10.4161/cc.9.13.12270  1
2010 Choo AY, Kim SG, Vander Heiden MG, Mahoney SJ, Vu H, Yoon SO, Cantley LC, Blenis J. Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply. Molecular Cell. 38: 487-99. PMID 20513425 DOI: 10.1016/j.molcel.2010.05.007  1
2010 Shin S, Dimitri CA, Yoon SO, Dowdle W, Blenis J. ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events. Molecular Cell. 38: 114-27. PMID 20385094 DOI: 10.1016/j.molcel.2010.02.020  1
2010 Hoffman GR, Moerke NJ, Hsia M, Shamu CE, Blenis J. A high-throughput, cell-based screening method for siRNA and small molecule inhibitors of mTORC1 signaling using the In Cell Western technique. Assay and Drug Development Technologies. 8: 186-99. PMID 20085456 DOI: 10.1089/adt.2009.0213  1
2010 Dempsey JM, Mahoney SJ, Blenis J. MTORC1-mediated control of protein translation Enzymes. 28: 1-20. DOI: 10.1016/S1874-6047(10)28001-0  1
2009 Mahoney SJ, Dempsey JM, Blenis J. Cell signaling in protein synthesis ribosome biogenesis and translation initiation and elongation. Progress in Molecular Biology and Translational Science. 90: 53-107. PMID 20374739 DOI: 10.1016/S1877-1173(09)90002-3  1
2009 Ma XM, Blenis J. Molecular mechanisms of mTOR-mediated translational control. Nature Reviews. Molecular Cell Biology. 10: 307-18. PMID 19339977 DOI: 10.1038/nrm2672  1
2009 Abe Y, Yoon SO, Kubota K, Mendoza MC, Gygi SP, Blenis J. p90 ribosomal S6 kinase and p70 ribosomal S6 kinase link phosphorylation of the eukaryotic chaperonin containing TCP-1 to growth factor, insulin, and nutrient signaling. The Journal of Biological Chemistry. 284: 14939-48. PMID 19332537 DOI: 10.1074/jbc.M900097200  1
2009 Choo AY, Blenis J. Not all substrates are treated equally: implications for mTOR, rapamycin-resistance and cancer therapy. Cell Cycle (Georgetown, Tex.). 8: 567-72. PMID 19197153  1
2009 Rahimi RA, Andrianifahanana M, Wilkes MC, Edens M, Kottom TJ, Blenis J, Leof EB. Distinct roles for mammalian target of rapamycin complexes in the fibroblast response to transforming growth factor-beta. Cancer Research. 69: 84-93. PMID 19117990 DOI: 10.1158/0008-5472.CAN-08-2146  1
2008 Choo AY, Yoon SO, Kim SG, Roux PP, Blenis J. Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation. Proceedings of the National Academy of Sciences of the United States of America. 105: 17414-9. PMID 18955708 DOI: 10.1073/pnas.0809136105  1
2008 Anjum R, Blenis J. The RSK family of kinases: emerging roles in cellular signalling. Nature Reviews. Molecular Cell Biology. 9: 747-58. PMID 18813292 DOI: 10.1038/nrm2509  1
2008 Carriere A, Ray H, Blenis J, Roux PP. The RSK factors of activating the Ras/MAPK signaling cascade. Frontiers in Bioscience : a Journal and Virtual Library. 13: 4258-75. PMID 18508509 DOI: 10.2741/3003  1
2008 Zhu J, Blenis J, Yuan J. Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1. Proceedings of the National Academy of Sciences of the United States of America. 105: 6584-9. PMID 18451027 DOI: 10.1073/pnas.0802785105  1
2008 Ma XM, Yoon SO, Richardson CJ, Jülich K, Blenis J. SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs. Cell. 133: 303-13. PMID 18423201 DOI: 10.1016/j.cell.2008.02.031  1
2008 Yoon SO, Shin S, Liu Y, Ballif BA, Woo MS, Gygi SP, Blenis J. Ran-binding protein 3 phosphorylation links the Ras and PI3-kinase pathways to nucleocytoplasmic transport. Molecular Cell. 29: 362-75. PMID 18280241 DOI: 10.1016/j.molcel.2007.12.024  1
2007 Mendoza MC, Blenis J. PHLPPing it off: phosphatases get in the Akt. Molecular Cell. 25: 798-800. PMID 17386258 DOI: 10.1016/j.molcel.2007.03.007  1
2007 Roux PP, Shahbazian D, Vu H, Holz MK, Cohen MS, Taunton J, Sonenberg N, Blenis J. RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation. The Journal of Biological Chemistry. 282: 14056-64. PMID 17360704 DOI: 10.1074/jbc.M700906200  1
2007 Zito CI, Qin H, Blenis J, Bennett AM. SHP-2 regulates cell growth by controlling the mTOR/S6 kinase 1 pathway. The Journal of Biological Chemistry. 282: 6946-53. PMID 17229738 DOI: 10.1074/jbc.M608338200  1
2007 Roux PP, Blenis J. MAPK signaling in human diseases Apoptosis, Cell Signaling, and Human Diseases. 2: 135-149. DOI: 10.1007/978-1-59745-199-4_6  1
2006 Choo AY, Roux PP, Blenis J. Mind the GAP: Wnt steps onto the mTORC1 train. Cell. 126: 834-6. PMID 16959561 DOI: 10.1016/j.cell.2006.08.025  1
2006 Shahbazian D, Roux PP, Mieulet V, Cohen MS, Raught B, Taunton J, Hershey JW, Blenis J, Pende M, Sonenberg N. The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. The Embo Journal. 25: 2781-91. PMID 16763566 DOI: 10.1038/sj.emboj.7601166  1
2006 Kim M, Lee JH, Koh H, Lee SY, Jang C, Chung CJ, Sung JH, Blenis J, Chung J. Inhibition of ERK-MAP kinase signaling by RSK during Drosophila development. The Embo Journal. 25: 3056-67. PMID 16763554 DOI: 10.1038/sj.emboj.7601180  1
2006 Hanrahan J, Blenis J. Rheb activation of mTOR and S6K1 signaling. Methods in Enzymology. 407: 542-55. PMID 16757352 DOI: 10.1016/S0076-6879(05)07044-8  1
2006 Liu L, Li F, Cardelli JA, Martin KA, Blenis J, Huang S. Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways. Oncogene. 25: 7029-40. PMID 16715128 DOI: 10.1038/sj.onc.1209691  1
2006 Murphy LO, Blenis J. MAPK signal specificity: the right place at the right time. Trends in Biochemical Sciences. 31: 268-75. PMID 16603362 DOI: 10.1016/j.tibs.2006.03.009  1
2006 Choo AY, Blenis J. TORgeting oncogene addiction for cancer therapy. Cancer Cell. 9: 77-9. PMID 16473275 DOI: 10.1016/j.ccr.2006.01.021  1
2006 Lewthwaite JC, Bastow ER, Lamb KJ, Blenis J, Wheeler-Jones CP, Pitsillides AA. A specific mechanomodulatory role for p38 MAPK in embryonic joint articular surface cell MEK-ERK pathway regulation. The Journal of Biological Chemistry. 281: 11011-8. PMID 16464862 DOI: 10.1074/jbc.M510680200  1
2005 Holz MK, Ballif BA, Gygi SP, Blenis J. mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell. 123: 569-80. PMID 16286006 DOI: 10.1016/j.cell.2005.10.024  1
2005 Anjum R, Roux PP, Ballif BA, Gygi SP, Blenis J. The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling. Current Biology : Cb. 15: 1762-7. PMID 16213824 DOI: 10.1016/j.cub.2005.08.050  1
2005 Tee AR, Blenis J, Proud CG. Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1. Febs Letters. 579: 4763-8. PMID 16098514 DOI: 10.1016/j.febslet.2005.07.054  1
2005 Dimitri CA, Dowdle W, MacKeigan JP, Blenis J, Murphy LO. Spatially separate docking sites on ERK2 regulate distinct signaling events in vivo. Current Biology : Cb. 15: 1319-24. PMID 16051177 DOI: 10.1016/j.cub.2005.06.037  1
2005 Holz MK, Blenis J. Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase. The Journal of Biological Chemistry. 280: 26089-93. PMID 15905173 DOI: 10.1074/jbc.M504045200  1
2005 Mackeigan JP, Murphy LO, Dimitri CA, Blenis J. Graded mitogen-activated protein kinase activity precedes switch-like c-Fos induction in mammalian cells. Molecular and Cellular Biology. 25: 4676-82. PMID 15899869 DOI: 10.1128/MCB.25.11.4676-4682.2005  1
2005 MacKeigan JP, Murphy LO, Blenis J. Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance. Nature Cell Biology. 7: 591-600. PMID 15864305 DOI: 10.1038/ncb1258  1
2005 Schalm SS, Tee AR, Blenis J. Characterization of a conserved C-terminal motif (RSPRR) in ribosomal protein S6 kinase 1 required for its mammalian target of rapamycin-dependent regulation. The Journal of Biological Chemistry. 280: 11101-6. PMID 15659381 DOI: 10.1074/jbc.M413995200  1
2005 Tee AR, Blenis J. mTOR, translational control and human disease. Seminars in Cell & Developmental Biology. 16: 29-37. PMID 15659337 DOI: 10.1016/j.semcdb.2004.11.005  1
2005 Ballif BA, Roux PP, Gerber SA, MacKeigan JP, Blenis J, Gygi SP. Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors. Proceedings of the National Academy of Sciences of the United States of America. 102: 667-72. PMID 15647351 DOI: 10.1073/pnas.0409143102  1
2004 Roux PP, Ballif BA, Anjum R, Gygi SP, Blenis J. Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. Proceedings of the National Academy of Sciences of the United States of America. 101: 13489-94. PMID 15342917 DOI: 10.1073/pnas.0405659101  1
2004 Richardson CJ, Bröenstrup M, Fingar DC, Jülich K, Ballif BA, Gygi S, Blenis J. SKAR is a specific target of S6 kinase 1 in cell growth control. Current Biology : Cb. 14: 1540-9. PMID 15341740 DOI: 10.1016/j.cub.2004.08.061  1
2004 McMullen JR, Shioi T, Zhang L, Tarnavski O, Sherwood MC, Dorfman AL, Longnus S, Pende M, Martin KA, Blenis J, Thomas G, Izumo S. Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophy. Molecular and Cellular Biology. 24: 6231-40. PMID 15226426 DOI: 10.1128/MCB.24.14.6231-6240.2004  1
2004 Richardson CJ, Schalm SS, Blenis J. PI3-kinase and TOR: PIKTORing cell growth. Seminars in Cell & Developmental Biology. 15: 147-59. PMID 15209374 DOI: 10.1016/j.semcdb.2003.12.023  1
2004 Roux PP, Blenis J. ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiology and Molecular Biology Reviews : Mmbr. 68: 320-44. PMID 15187187 DOI: 10.1128/MMBR.68.2.320-344.2004  1
2004 Fingar DC, Blenis J. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene. 23: 3151-71. PMID 15094765 DOI: 10.1038/sj.onc.1207542  1
2004 Tee AR, Tee JA, Blenis J. Characterizing the interaction of the mammalian eIF4E-related protein 4EHP with 4E-BP1. Febs Letters. 564: 58-62. PMID 15094042 DOI: 10.1016/S0014-5793(04)00313-8  1
2004 Woo MS, Ohta Y, Rabinovitz I, Stossel TP, Blenis J. Ribosomal S6 kinase (RSK) regulates phosphorylation of filamin A on an important regulatory site. Molecular and Cellular Biology. 24: 3025-35. PMID 15024089 DOI: 10.1128/MCB.24.7.3025-3035.2004  1
2004 Fingar DC, Richardson CJ, Tee AR, Cheatham L, Tsou C, Blenis J. mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Molecular and Cellular Biology. 24: 200-16. PMID 14673156 DOI: 10.1128/MCB.24.1.200-216.2004  1
2004 Murphy LO, MacKeigan JP, Blenis J. A network of immediate early gene products propagates subtle differences in mitogen-activated protein kinase signal amplitude and duration. Molecular and Cellular Biology. 24: 144-53. PMID 14673150 DOI: 10.1128/MCB.24.1.144-153.2004  1
2004 Qian Y, Corum L, Meng Q, Blenis J, Zheng JZ, Shi X, Flynn DC, Jiang BH. PI3K induced actin filament remodeling through Akt and p70S6K1: implication of essential role in cell migration. American Journal of Physiology. Cell Physiology. 286: C153-63. PMID 12967912 DOI: 10.1152/ajpcell.00142.2003  1
2003 Agrawal S, Agrawal A, Doughty B, Gerwitz A, Blenis J, Van Dyke T, Pulendran B. Cutting edge: different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos. Journal of Immunology (Baltimore, Md. : 1950). 171: 4984-9. PMID 14607893  1
2003 Tee AR, Manning BD, Roux PP, Cantley LC, Blenis J. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Current Biology : Cb. 13: 1259-68. PMID 12906785 DOI: 10.1016/S0960-9822(03)00506-2  1
2003 Tee AR, Anjum R, Blenis J. Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin. The Journal of Biological Chemistry. 278: 37288-96. PMID 12867426 DOI: 10.1074/jbc.M303257200  1
2003 Roux PP, Richards SA, Blenis J. Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity. Molecular and Cellular Biology. 23: 4796-804. PMID 12832467 DOI: 10.1128/MCB.23.14.4796-4804.2003  1
2003 Schalm SS, Fingar DC, Sabatini DM, Blenis J. TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function. Current Biology : Cb. 13: 797-806. PMID 12747827 DOI: 10.1016/S0960-9822(03)00329-4  1
2002 Martin KA, Blenis J. Coordinate regulation of translation by the PI 3-kinase and mTOR pathways. Advances in Cancer Research. 86: 1-39. PMID 12374276 DOI: 10.1016/S0065-230X(02)86001-8  1
2002 Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J. Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proceedings of the National Academy of Sciences of the United States of America. 99: 13571-6. PMID 12271141 DOI: 10.1073/pnas.202476899  1
2002 Romanelli A, Dreisbach VC, Blenis J. Characterization of phosphatidylinositol 3-kinase-dependent phosphorylation of the hydrophobic motif site Thr(389) in p70 S6 kinase 1. The Journal of Biological Chemistry. 277: 40281-9. PMID 12183455 DOI: 10.1074/jbc.M205168200  1
2002 Manning BD, Tee AR, Logsdon MN, Blenis J, Cantley LC. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Molecular Cell. 10: 151-62. PMID 12150915 DOI: 10.1016/S1097-2765(02)00568-3  1
2002 Murphy LO, Smith S, Chen RH, Fingar DC, Blenis J. Molecular interpretation of ERK signal duration by immediate early gene products. Nature Cell Biology. 4: 556-64. PMID 12134156 DOI: 10.1038/ncb822  1
2002 Fingar DC, Salama S, Tsou C, Harlow E, Blenis J. Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes & Development. 16: 1472-87. PMID 12080086 DOI: 10.1101/gad.995802  1
2002 Schalm SS, Blenis J. Identification of a conserved motif required for mTOR signaling. Current Biology : Cb. 12: 632-9. PMID 11967149 DOI: 10.1016/S0960-9822(02)00762-5  1
2001 Richards SA, Dreisbach VC, Murphy LO, Blenis J. Characterization of regulatory events associated with membrane targeting of p90 ribosomal S6 kinase 1. Molecular and Cellular Biology. 21: 7470-80. PMID 11585927 DOI: 10.1128/MCB.21.21.7470-7480.2001  1
2001 Kischkel FC, Lawrence DA, Tinel A, LeBlanc H, Virmani A, Schow P, Gazdar A, Blenis J, Arnott D, Ashkenazi A. Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8. The Journal of Biological Chemistry. 276: 46639-46. PMID 11583996 DOI: 10.1074/jbc.M105102200  1
2001 Podsypanina K, Lee RT, Politis C, Hennessy I, Crane A, Puc J, Neshat M, Wang H, Yang L, Gibbons J, Frost P, Dreisbach V, Blenis J, Gaciong Z, Fisher P, et al. An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice. Proceedings of the National Academy of Sciences of the United States of America. 98: 10320-5. PMID 11504907 DOI: 10.1073/pnas.171060098  1
2001 Ballif BA, Blenis J. Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell survival signals. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 12: 397-408. PMID 11504705  1
2001 Chen CY, Juo P, Liou JS, Li CQ, Yu Q, Blenis J, Faller DV. The recruitment of Fas-associated death domain/caspase-8 in Ras-induced apoptosis. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 12: 297-306. PMID 11432804  1
2001 Siegmund D, Mauri D, Peters N, Juo P, Thome M, Reichwein M, Blenis J, Scheurich P, Tschopp J, Wajant H. Fas-associated death domain protein (FADD) and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) via a FLICE inhibitory protein (FLIP)-regulated pathway. The Journal of Biological Chemistry. 276: 32585-90. PMID 11384965 DOI: 10.1074/jbc.M100444200  1
2001 Ballif BA, Shimamura A, Pae E, Blenis J. Disruption of 3-phosphoinositide-dependent kinase 1 (PDK1) signaling by the anti-tumorigenic and anti-proliferative agent n-alpha-tosyl-l-phenylalanyl chloromethyl ketone. The Journal of Biological Chemistry. 276: 12466-75. PMID 11278584 DOI: 10.1074/jbc.M009939200  1
2001 Verhey KJ, Meyer D, Deehan R, Blenis J, Schnapp BJ, Rapoport TA, Margolis B. Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules. The Journal of Cell Biology. 152: 959-70. PMID 11238452 DOI: 10.1083/jcb.152.5.959  1
2001 Martin KA, Schalm SS, Romanelli A, Keon KL, Blenis J. Ribosomal S6 kinase 2 inhibition by a potent C-terminal repressor domain is relieved by mitogen-activated protein-extracellular signal-regulated kinase kinase-regulated phosphorylation. The Journal of Biological Chemistry. 276: 7892-8. PMID 11108720 DOI: 10.1074/jbc.M009972200  1
2001 Martin KA, Schalm SS, Richardson C, Romanelli A, Keon KL, Blenis J. Regulation of ribosomal S6 kinase 2 by effectors of the phosphoinositide 3-kinase pathway. The Journal of Biological Chemistry. 276: 7884-91. PMID 11108711 DOI: 10.1074/jbc.M006969200  1
2000 Ding HF, Lin YL, McGill G, Juo P, Zhu H, Blenis J, Yuan J, Fisher DE. Essential role for caspase-8 in transcription-independent apoptosis triggered by p53. The Journal of Biological Chemistry. 275: 38905-11. PMID 10988287 DOI: 10.1074/jbc.M004714200  1
2000 Sprick MR, Weigand MA, Rieser E, Rauch CT, Juo P, Blenis J, Krammer PH, Walczak H. FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2. Immunity. 12: 599-609. PMID 10894160  1
2000 Bodmer JL, Holler N, Reynard S, Vinciguerra P, Schneider P, Juo P, Blenis J, Tschopp J. TRAIL receptor-2 signals apoptosis through FADD and caspase-8. Nature Cell Biology. 2: 241-3. PMID 10783243 DOI: 10.1038/35008667  0.32
2000 Kwon EM, Raines MA, Blenis J, Sakamoto KM. Granulocyte-macrophage colony-stimulating factor stimulation results in phosphorylation of cAMP response element-binding protein through activation of pp90RSK. Blood. 95: 2552-8. PMID 10753834  1
2000 Shimamura A, Ballif BA, Richards SA, Blenis J. Rsk1 mediates a MEK-MAP kinase cell survival signal. Current Biology : Cb. 10: 127-35. PMID 10679322 DOI: 10.1016/S0960-9822(00)00310-9  1
1999 Juo P, Woo MS, Kuo CJ, Signorelli P, Biemann HP, Hannun YA, Blenis J. FADD is required for multiple signaling events downstream of the receptor Fas. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 10: 797-804. PMID 10616904  1
1999 Lee-Fruman KK, Kuo CJ, Lippincott J, Terada N, Blenis J. Characterization of S6K2, a novel kinase homologous to S6K1. Oncogene. 18: 5108-14. PMID 10490847 DOI: 10.1038/sj.onc.1202894  1
1999 Richards SA, Fu J, Romanelli A, Shimamura A, Blenis J. Ribosomal S6 kinase 1 (RSK1) activation requires signals dependent on and independent of the MAP kinase ERK. Current Biology : Cb. 9: 810-20. PMID 10469565 DOI: 10.1016/S0960-9822(99)80364-9  1
1999 Sánchez I, Xu CJ, Juo P, Kakizaka A, Blenis J, Yuan J. Caspase-8 is required for cell death induced by expanded polyglutamine repeats. Neuron. 22: 623-33. PMID 10197541  1
1999 Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell. 96: 857-68. PMID 10102273  1
1999 Romanelli A, Martin KA, Toker A, Blenis J. p70 S6 kinase is regulated by protein kinase Czeta and participates in a phosphoinositide 3-kinase-regulated signalling complex. Molecular and Cellular Biology. 19: 2921-8. PMID 10082559  1
1998 Oehrl W, Kardinal C, Ruf S, Adermann K, Groffen J, Feng GS, Blenis J, Tan TH, Feller SM. The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins. Oncogene. 17: 1893-901. PMID 9788432 DOI: 10.1038/sj.onc.1202108  1
1998 Juo P, Kuo CJ, Yuan J, Blenis J. Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade. Current Biology : Cb. 8: 1001-8. PMID 9740801  1
1998 Joel PB, Smith J, Sturgill TW, Fisher TL, Blenis J, Lannigan DA. pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167. Molecular and Cellular Biology. 18: 1978-84. PMID 9528769  1
1997 Schinkmann K, Blenis J. Cloning and characterization of a human STE20-like protein kinase with unusual cofactor requirements. The Journal of Biological Chemistry. 272: 28695-703. PMID 9353338 DOI: 10.1074/jbc.272.45.28695  1
1997 Chung J, Uchida E, Grammer TC, Blenis J. STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation. Molecular and Cellular Biology. 17: 6508-16. PMID 9343414  1
1997 Grammer TC, Blenis J. Evidence for MEK-independent pathways regulating the prolonged activation of the ERK-MAP kinases. Oncogene. 14: 1635-42. PMID 9135064 DOI: 10.1038/sj.onc.1201000  1
1997 Tung RM, Blenis J. A novel human SPS1/STE20 homologue, KHS, activates Jun N-terminal kinase. Oncogene. 14: 653-9. PMID 9038372 DOI: 10.1038/sj.onc.1200877  1
1997 Pende M, Fisher TL, Simpson PB, Russell JT, Blenis J, Gallo V. Neurotransmitter- and growth factor-induced cAMP response element binding protein phosphorylation in glial cell progenitors: role of calcium ions, protein kinase C, and mitogen-activated protein kinase/ribosomal S6 kinase pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 1291-301. PMID 9006973  1
1997 Juo P, Kuo CJ, Reynolds SE, Konz RF, Raingeaud J, Davis RJ, Biemann HP, Blenis J. Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteases. Molecular and Cellular Biology. 17: 24-35. PMID 8972182  1
1996 Watson KL, Chou MM, Blenis J, Gelbart WM, Erikson RL. A Drosophila gene structurally and functionally homologous to the mammalian 70-kDa s6 kinase gene. Proceedings of the National Academy of Sciences of the United States of America. 93: 13694-8. PMID 8942996 DOI: 10.1073/pnas.93.24.13694  1
1996 Grammer TC, Cheatham L, Chou MM, Blenis J. The p70S6K signalling pathway: a novel signalling system involved in growth regulation. Cancer Surveys. 27: 271-92. PMID 8909805  1
1996 Songyang Z, Lu KP, Kwon YT, Tsai LH, Filhol O, Cochet C, Brickey DA, Soderling TR, Bartleson C, Graves DJ, DeMaggio AJ, Hoekstra MF, Blenis J, Hunter T, Cantley LC. A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1. Molecular and Cellular Biology. 16: 6486-93. PMID 8887677  1
1996 Monfar M, Blenis J. Inhibition of p70/p85 S6 kinase activities in T cells by dexamethasone. Molecular Endocrinology (Baltimore, Md.). 10: 1107-15. PMID 8885245 DOI: 10.1210/mend.10.9.8885245  1
1996 Grammer TC, Blenis J. The serine protease inhibitors, tosylphenylalanine chloromethyl ketone and tosyllysine chloromethyl ketone, potently inhibit pp70s6k activation. The Journal of Biological Chemistry. 271: 23650-2. PMID 8798584 DOI: 10.1074/jbc.271.39.23650  1
1996 Nakajima T, Fukamizu A, Takahashi J, Gage FH, Fisher T, Blenis J, Montminy MR. The signal-dependent coactivator CBP is a nuclear target for pp90RSK. Cell. 86: 465-74. PMID 8756728 DOI: 10.1016/S0092-8674(00)80119-1  1
1996 Myers MG, Zhang Y, Aldaz GA, Grammer T, Glasheen EM, Yenush L, Wang LM, Sun XJ, Blenis J, Pierce JH, White MF. YMXM motifs and signaling by an insulin receptor substrate 1 molecule without tyrosine phosphorylation sites. Molecular and Cellular Biology. 16: 4147-55. PMID 8754813  1
1996 Chou MM, Blenis J. The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1. Cell. 85: 573-83. PMID 8653792 DOI: 10.1016/S0092-8674(00)81257-X  1
1996 Dahl J, Freund R, Blenis J, Benjamin TL. Studies of partially transforming polyomavirus mutants establish a role for phosphatidylinositol 3-kinase in activation of pp70 S6 kinase. Molecular and Cellular Biology. 16: 2728-35. PMID 8649380  1
1996 Yenush L, Fernandez R, Myers MG, Grammer TC, Sun XJ, Blenis J, Pierce JH, Schlessinger J, White MF. The Drosophila insulin receptor activates multiple signaling pathways but requires insulin receptor substrate proteins for DNA synthesis. Molecular and Cellular Biology. 16: 2509-17. PMID 8628319  1
1996 Chen RH, Juo PC, Curran T, Blenis J. Phosphorylation of c-Fos at the C-terminus enhances its transforming activity. Oncogene. 12: 1493-502. PMID 8622865  1
1996 Fisher TL, Blenis J. Evidence for two catalytically active kinase domains in pp90rsk. Molecular and Cellular Biology. 16: 1212-9. PMID 8622665  1
1995 Chou MM, Blenis J. The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling. Current Opinion in Cell Biology. 7: 806-14. PMID 8608011 DOI: 10.1016/0955-0674(95)80064-6  1
1995 Cheatham L, Monfar M, Chou MM, Blenis J. Structural and functional analysis of pp70S6k. Proceedings of the National Academy of Sciences of the United States of America. 92: 11696-700. PMID 8524831  1
1995 Karnitz LM, Burns LA, Sutor SL, Blenis J, Abraham RT. Interleukin-2 triggers a novel phosphatidylinositol 3-kinase-dependent MEK activation pathway. Molecular and Cellular Biology. 15: 3049-57. PMID 7760801  1
1995 Myers MG, Grammer TC, Brooks J, Glasheen EM, Wang LM, Sun XJ, Blenis J, Pierce JH, White MF. The pleckstrin homology domain in insulin receptor substrate-1 sensitizes insulin signaling. The Journal of Biological Chemistry. 270: 11715-8. PMID 7744813 DOI: 10.1074/jbc.270.20.11715  1
1995 Zhang X, Blenis J, Li HC, Schindler C, Chen-Kiang S. Requirement of serine phosphorylation for formation of STAT-promoter complexes. Science (New York, N.Y.). 267: 1990-4. PMID 7701321  1
1995 Dumont FJ, Staruch MJ, Grammer T, Blenis J, Kastner CA, Rupprecht KM. Dominant mutations confer resistance to the immunosuppressant, rapamycin, in variants of a T cell lymphoma. Cellular Immunology. 163: 70-9. PMID 7538911 DOI: 10.1006/cimm.1995.1100  1
1995 Monfar M, Lemon KP, Grammer TC, Cheatham L, Chung J, Vlahos CJ, Blenis J. Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP. Molecular and Cellular Biology. 15: 326-37. PMID 7528328  1
1994 Dumont FJ, Altmeyer A, Kastner C, Fischer PA, Lemon KP, Chung J, Blenis J, Staruch MJ. Relationship between multiple biologic effects of rapamycin and the inhibition of pp70S6 protein kinase activity. Analysis in mutant clones of a T cell lymphoma. Journal of Immunology (Baltimore, Md. : 1950). 152: 992-1003. PMID 8301150  1
1994 Papkoff J, Chen RH, Blenis J, Forsman J. p42 mitogen-activated protein kinase and p90 ribosomal S6 kinase are selectively phosphorylated and activated during thrombin-induced platelet activation and aggregation. Molecular and Cellular Biology. 14: 463-72. PMID 8264614  1
1994 Kharbanda S, Saleem A, Hirano M, Emoto Y, Sukhatme V, Blenis J, Kufe D. Activation of early growth response 1 gene transcription and pp90rsk during induction of monocytic differentiation. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 5: 259-65. PMID 8018558  1
1994 Chung J, Grammer TC, Lemon KP, Kazlauskas A, Blenis J. PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase. Nature. 370: 71-5. PMID 8015612 DOI: 10.1038/370071a0  1
1994 Cheatham B, Vlahos CJ, Cheatham L, Wang L, Blenis J, Kahn CR. Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. Molecular and Cellular Biology. 14: 4902-11. PMID 8007986  1
1994 Myers MG, Grammer TC, Wang LM, Sun XJ, Pierce JH, Blenis J, White MF. Insulin receptor substrate-1 mediates phosphatidylinositol 3'-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation. The Journal of Biological Chemistry. 269: 28783-9. PMID 7961833  1
1993 Rivera VM, Miranti CK, Misra RP, Ginty DD, Chen RH, Blenis J, Greenberg ME. A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity. Molecular and Cellular Biology. 13: 6260-73. PMID 8413226  1
1993 Blenis J. Signal transduction via the MAP kinases: proceed at your own RSK. Proceedings of the National Academy of Sciences of the United States of America. 90: 5889-92. PMID 8392180  1
1993 Terada N, Franklin RA, Lucas JJ, Blenis J, Gelfand EW. Failure of rapamycin to block proliferation once resting cells have entered the cell cycle despite inactivation of p70 S6 kinase. The Journal of Biological Chemistry. 268: 12062-8. PMID 8389370  1
1993 Chen RH, Abate C, Blenis J. Phosphorylation of the c-Fos transrepression domain by mitogen-activated protein kinase and 90-kDa ribosomal S6 kinase. Proceedings of the National Academy of Sciences of the United States of America. 90: 10952-6. PMID 8248197  1
1993 Davis IJ, Hazel TG, Chen RH, Blenis J, Lau LF. Functional domains and phosphorylation of the orphan receptor Nur77. Molecular Endocrinology (Baltimore, Md.). 7: 953-64. PMID 8232315 DOI: 10.1210/mend.7.8.8232315  1
1993 Chen RH, Tung R, Abate C, Blenis J. Cytoplasmic to nuclear signal transduction by mitogen-activated protein kinase and 90 kDa ribosomal S6 kinase. Biochemical Society Transactions. 21: 895-900. PMID 8132089  1
1993 Blenis J, Resh MD. Subcellular localization specified by protein acylation and phosphorylation. Current Opinion in Cell Biology. 5: 984-9. PMID 8129952  1
1993 Kharbanda S, Saleem A, Rubin E, Sukhatme V, Blenis J, Kufe D. Activation of the early growth response 1 gene and nuclear pp90rsk in human myeloid leukemia cells by 1-(beta-D-arabinofuranosyl)cytosine. Biochemistry. 32: 9137-42. PMID 7690249  1
1993 Fingar DC, Hausdorff SF, Blenis J, Birnbaum MJ. Dissociation of pp70 ribosomal protein S6 kinase from insulin-stimulated glucose transport in 3T3-L1 adipocytes. The Journal of Biological Chemistry. 268: 3005-8. PMID 7679106  1
1993 Tsai M, Chen RH, Tam SY, Blenis J, Galli SJ. Activation of MAP kinases, pp90rsk and pp70-S6 kinases in mouse mast cells by signaling through the c-kit receptor tyrosine kinase or Fc epsilon RI: rapamycin inhibits activation of pp70-S6 kinase and proliferation in mouse mast cells. European Journal of Immunology. 23: 3286-91. PMID 7504992 DOI: 10.1002/eji.1830231234  1
1992 Kuo CJ, Chung J, Fiorentino DF, Flanagan WM, Blenis J, Crabtree GR. Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature. 358: 70-3. PMID 1614535 DOI: 10.1038/358070a0  1
1992 Chen RH, Sarnecki C, Blenis J. Nuclear localization and regulation of erk- and rsk-encoded protein kinases. Molecular and Cellular Biology. 12: 915-27. PMID 1545823  1
1992 Chung J, Kuo CJ, Crabtree GR, Blenis J. Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. Cell. 69: 1227-36. PMID 1377606 DOI: 10.1016/0092-8674(92)90643-Q  1
1992 Wood KW, Sarnecki C, Roberts TM, Blenis J. ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK. Cell. 68: 1041-50. PMID 1312393 DOI: 10.1016/0092-8674(92)90076-O  1
1991 Chung J, Pelech SL, Blenis J. Mitogen-activated Swiss mouse 3T3 RSK kinases I and II are related to pp44mpk from sea star oocytes and participate in the regulation of pp90rsk activity. Proceedings of the National Academy of Sciences of the United States of America. 88: 4981-5. PMID 2052581  1
1991 Jurivich DA, Chung J, Blenis J. Heat shock induces two distinct S6 protein kinase activities in quiescent mammalian fibroblasts. Journal of Cellular Physiology. 148: 252-9. PMID 1880153 DOI: 10.1002/jcp.1041480210  1
1991 Chen RH, Chung J, Blenis J. Regulation of pp90rsk phosphorylation and S6 phosphotransferase activity in Swiss 3T3 cells by growth factor-, phorbol ester-, and cyclic AMP-mediated signal transduction. Molecular and Cellular Biology. 11: 1861-7. PMID 1848664  1
1991 Chung J, Chen RH, Blenis J. Coordinate regulation of pp90rsk and a distinct protein-serine/threonine kinase activity that phosphorylates recombinant pp90rsk in vitro. Molecular and Cellular Biology. 11: 1868-74. PMID 1826043  1
1991 Blenis J. Growth-regulated signal transduction by the MAP kinases and RSKs. Cancer Cells (Cold Spring Harbor, N.Y. : 1989). 3: 445-9. PMID 1662059  1
1991 Blenis J, Chung J, Erikson E, Alcorta DA, Erikson RL. Distinct mechanisms for the activation of the RSK kinases/MAP2 kinase/pp90rsk and pp70-S6 kinase signaling systems are indicated by inhibition of protein synthesis. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 2: 279-85. PMID 1648378  1
1990 Chen RH, Blenis J. Identification of Xenopus S6 protein kinase homologs (pp90rsk) in somatic cells: phosphorylation and activation during initiation of cell proliferation. Molecular and Cellular Biology. 10: 3204-15. PMID 2342472  1
1988 Jones SW, Erikson E, Blenis J, Maller JL, Erikson RL. A Xenopus ribosomal protein S6 kinase has two apparent kinase domains that are each similar to distinct protein kinases. Proceedings of the National Academy of Sciences of the United States of America. 85: 3377-81. PMID 3368449  1
1988 Erikson RL, Alcorta D, Bedard PA, Blenis J, Biemann HP, Erikson E, Jones SW, Maller JL, Martins TJ, Simmons DL. Molecular analyses of gene products associated with the response of cells to mitogenic stimulation. Cold Spring Harbor Symposia On Quantitative Biology. 53: 143-51. PMID 3151166  1
1988 Talmage DA, Blenis J, Benjamin TL. Polyomavirus middle T antigen induces ribosomal protein S6 phosphorylation through pp60c-src-dependent and -independent pathways. Molecular and Cellular Biology. 8: 2309-15. PMID 2457149  1
1987 Erikson E, Stefanovic D, Blenis J, Erikson RL, Maller JL. Antibodies to Xenopus egg S6 kinase II recognize S6 kinase from progesterone- and insulin-stimulated Xenopus oocytes and from proliferating chicken embryo fibroblasts. Molecular and Cellular Biology. 7: 3147-55. PMID 3313008  1
1987 Blenis J, Kuo CJ, Erikson RL. Identification of a ribosomal protein S6 kinase regulated by transformation and growth-promoting stimuli. The Journal of Biological Chemistry. 262: 14373-6. PMID 2822690  1
1987 Blenis J, Kuo CJ, Alcorta DA, Erikson RL. Role of second messengers in regulating the growth-associated S6 protein kinase activity. Progress in Clinical and Biological Research. 249: 181-92. PMID 2444994  1
1986 Blenis J, Erikson RL. Stimulation of ribosomal protein S6 kinase activity by pp60v-src or by serum: dissociation from phorbol ester-stimulated activity. Proceedings of the National Academy of Sciences of the United States of America. 83: 1733-7. PMID 3081899  1
1986 Blenis J, Erikson RL. Regulation of protein kinase activities in PC12 pheochromocytoma cells. The Embo Journal. 5: 3441-7. PMID 3030727  1
1985 Blenis J, Erikson RL. Regulation of a ribosomal protein S6 kinase activity by the Rous sarcoma virus transforming protein, serum, or phorbol ester. Proceedings of the National Academy of Sciences of the United States of America. 82: 7621-5. PMID 3934663  1
1984 Blenis J, Hawkes SP. Characterization of a transformation-sensitive protein in the extracellular matrix of chicken embryo fibroblasts. The Journal of Biological Chemistry. 259: 11563-70. PMID 6432799  1
1984 Blenis J, Erikson RL. Phosphorylation of the ribosomal protein S6 is elevated in cells transformed by a variety of tumor viruses. Journal of Virology. 50: 966-9. PMID 6328026  1
1984 Blenis J, Spivack JG, Erikson RL. Phorbol ester, serum, and rous sarcoma virus transforming gene product induce similar phosphorylations of ribosomal protein S6. Proceedings of the National Academy of Sciences of the United States of America. 81: 6408-12. PMID 6093101  1
1983 Roff CF, Wozniak RW, Blenis J, Wang JL. The effect of mannose6-phosphate on the turnover of cell surface glycosaminoglycans. Experimental Cell Research. 144: 333-44. PMID 6404644 DOI: 10.1016/0014-4827(83)90412-3  1
1983 Blenis J, Hawkes SP. Transformation-sensitive protein associated with the cell substratum of chicken embryo fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 80: 770-4. PMID 6298774  1
1982 Steck PA, Blenis J, Voss PG, Wang JL. Growth control in cultured 3T3 fibroblasts II. Molecular properties of a fraction enriched in growth inhibitory activity. The Journal of Cell Biology. 92: 523-30. PMID 7061594  1
1982 Parry G, Blenis J, Hawkes SP. Detection of transformed cells using a fluorescent probe: the molecular basis for the differential reaction of fluorescamine with normal and transformed cells. Cytometry. 3: 97-103. PMID 6291884 DOI: 10.1002/cyto.990030206  1
1980 Nilson JH, Thomason AR, Horowitz S, Sasavage NL, Blenis J, Albers R, Salser W, Rottman FM. Construction and characterization of a cDNA clone containing a portion of the bovine prolactin sequence. Nucleic Acids Research. 8: 1561-73. PMID 7001369 DOI: 10.1093/nar/8.7.1561  1
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