John W. Regan - Publications

Affiliations: 
Neuroscience University of Arizona, Tucson, AZ 
Area:
Neuroscience Biology, Pharmacology, Cell Biology

136 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

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Year Citation  Score
2021 Okura I, Hasuoka N, Senoo K, Suganami A, Fukushima K, Regan JW, Mashimo M, Murayama T, Tamura Y, Fujino H. The differential functional coupling of phosphodiesterase 4 to human DP and EP2 prostanoid receptors stimulated with PGD or PGE. Pharmacological Reports : Pr. PMID 33786738 DOI: 10.1007/s43440-021-00247-x  0.68
2020 Endo S, Suganami A, Fukushima K, Senoo K, Araki Y, Regan JW, Mashimo M, Tamura Y, Fujino H. 15-keto-PGEacts as a biased/partial agonist to terminate PGE-evoked signaling. The Journal of Biological Chemistry. PMID 32727851 DOI: 10.1074/jbc.RA120.013988  0.68
2019 Kurata N, Tokashiki N, Fukushima K, Misao T, Hasuoka N, Kitagawa K, Mashimo M, Regan JW, Murayama T, Fujino H. Short chain fatty acid butyrate uptake reduces expressions of prostanoid EP receptors and their mediation of cyclooxygenase-2 induction in HCA-7 human colon cancer cells. European Journal of Pharmacology. 853: 308-315. PMID 30980797 DOI: 10.1016/j.ejphar.2019.04.014  0.68
2018 Seira N, Yamagata K, Fukushima K, Araki Y, Kurata N, Yanagisawa N, Mashimo M, Nakamura H, Regan JW, Murayama T, Fujino H. Cellular density-dependent increases in HIF-1α compete with c-Myc to down-regulate human EP4 receptor promoter activity through Sp-1-binding region. Pharmacology Research & Perspectives. 6: e00441. PMID 30455960 DOI: 10.1002/prp2.441  0.68
2017 Araki Y, Suganami A, Endo S, Masuda Y, Fukushima K, Regan JW, Murayama T, Tamura Y, Fujino H. PGE1 and E3 show lower efficacies than E2 to β-catenin-mediated activity as biased ligands of EP4 prostanoid receptors. Febs Letters. PMID 28986997 DOI: 10.1002/1873-3468.12878  0.68
2017 Seira N, Yanagisawa N, Suganami A, Honda T, Wasai M, Regan JW, Fukushima K, Yamaguchi N, Tamura Y, Arai T, Murayama T, Fujino H. Anti-cancer Effects of MW-03, a Novel Indole Compound, by Inducing 15-Hydroxyprostaglandin Dehydrogenase and Cellular Growth Inhibition in the LS174T Human Colon Cancer Cell Line. Biological & Pharmaceutical Bulletin. 40: 1806-1812. PMID 28966256 DOI: 10.1248/bpb.b17-00458  0.68
2016 Suganami A, Fujino H, Okura I, Yanagisawa N, Sugiyama H, Regan JW, Tamura Y, Murayama T. Human DP and EP2 prostanoid receptors take on distinct forms depending on the diverse binding of different ligands. The Febs Journal. PMID 27636113 DOI: 10.1111/febs.13899  0.68
2015 Fujino H, Seira N, Kurata N, Araki Y, Nakamura H, Regan JW, Murayama T. Prostaglandin E2-stimulated prostanoid EP4 receptors induce prolonged de novo prostaglandin E2 synthesis through biphasic phosphorylation of extracellular signal-regulated kinases mediated by activation of protein kinase A in HCA-7 human colon cancer cells. European Journal of Pharmacology. PMID 26518053 DOI: 10.1016/j.ejphar.2015.10.044  0.88
2015 Otake S, Yoshida K, Seira N, Sanchez CM, Regan JW, Fujino H, Murayama T. Cellular density-dependent down-regulation of EP4 prostanoid receptors via the up-regulation of hypoxia-inducible factor-1α in HCA-7 human colon cancer cells. Pharmacology Research & Perspectives. 3: e00083. PMID 25692008 DOI: 10.1002/prp2.83  0.68
2014 Oyama S, Fujino H, Yamazaki R, Okura I, Regan JW, Awata A, Arai T, Murayama T. A novel indole compound, AWT-489, inhibits prostaglandin D2-induced CD55 expression by acting on DP prostanoid receptors as an antagonist in LS174T human colon cancer cells. Archives of Biochemistry and Biophysics. 541: 21-9. PMID 24239863 DOI: 10.1016/j.abb.2013.10.023  0.88
2013 Yoshida K, Fujino H, Otake S, Seira N, Regan JW, Murayama T. Induction of cyclooxygenase-2 expression by prostaglandin E2 stimulation of the prostanoid EP4 receptor via coupling to Gαi and transactivation of the epidermal growth factor receptor in HCA-7 human colon cancer cells. European Journal of Pharmacology. 718: 408-17. PMID 23973650 DOI: 10.1016/j.ejphar.2013.08.002  0.88
2012 Ji R, Sanchez CM, Chou CL, Chen XB, Woodward DF, Regan JW. Prostanoid EP₁ receptors mediate up-regulation of the orphan nuclear receptor Nurr1 by cAMP-independent activation of protein kinase A, CREB and NF-κB. British Journal of Pharmacology. 166: 1033-46. PMID 22188298 DOI: 10.1111/j.1476-5381.2011.01817.x  0.88
2011 Fujino H, Toyomura K, Chen XB, Regan JW, Murayama T. Prostaglandin E₂ regulates cellular migration via induction of vascular endothelial growth factor receptor-1 in HCA-7 human colon cancer cells. Biochemical Pharmacology. 81: 379-87. PMID 21070749 DOI: 10.1016/j.bcp.2010.11.001  0.88
2011 Salinthone S, Schillace RV, Tsang C, Regan JW, Bourdette DN, Carr DW. Lipoic acid stimulates cAMP production via G protein-coupled receptor-dependent and -independent mechanisms. The Journal of Nutritional Biochemistry. 22: 681-90. PMID 21036588 DOI: 10.1016/j.jnutbio.2010.05.008  0.88
2010 Fujino H, Murayama T, Regan JW. Assessment of constitutive activity in E-type prostanoid receptors. Methods in Enzymology. 484: 95-107. PMID 21036228 DOI: 10.1016/B978-0-12-381298-8.00005-8  0.88
2010 Chandramouli A, Mercado-Pimentel ME, Hutchinson A, Gibadulinová A, Olson ER, Dickinson S, Shañas R, Davenport J, Owens J, Bhattacharyya AK, Regan JW, Pastorekova S, Arumugam T, Logsdon CD, Nelson MA. The induction of S100p expression by the Prostaglandin E₂ (PGE₂)/EP4 receptor signaling pathway in colon cancer cells. Cancer Biology & Therapy. 10: 1056-66. PMID 20890108 DOI: 10.4161/cbt.10.10.13373  0.88
2010 Hutchinson AJ, Coons SC, Chou CL, Xu W, Stamer WD, Woodward DF, Regan JW. Induction of angiogenic immediate early genes by activation of FP prostanoid receptors in cultured human ciliary smooth muscle cells. Current Eye Research. 35: 408-18. PMID 20450254 DOI: 10.3109/02713680903581021  0.88
2010 Ji R, Chou CL, Xu W, Chen XB, Woodward DF, Regan JW. EP1 prostanoid receptor coupling to G i/o up-regulates the expression of hypoxia-inducible factor-1 alpha through activation of a phosphoinositide-3 kinase signaling pathway. Molecular Pharmacology. 77: 1025-36. PMID 20335389 DOI: 10.1124/mol.110.063933  0.88
2009 Hutchinson AJ, Chou CL, Israel DD, Xu W, Regan JW. Activation of EP2 prostanoid receptors in human glial cell lines stimulates the secretion of BDNF. Neurochemistry International. 54: 439-46. PMID 19428786 DOI: 10.1016/j.neuint.2009.01.018  0.88
2009 Israel DD, Regan JW. EP(3) prostanoid receptor isoforms utilize distinct mechanisms to regulate ERK 1/2 activation. Biochimica Et Biophysica Acta. 1791: 238-45. PMID 19416642 DOI: 10.1016/j.bbalip.2009.01.021  0.88
2009 Xu W, Chou CL, Israel DD, Hutchinson AJ, Regan JW. PGF(2alpha) stimulates FP prostanoid receptor mediated crosstalk between Ras/Raf signaling and Tcf transcriptional activation. Biochemical and Biophysical Research Communications. 381: 625-9. PMID 19248765 DOI: 10.1016/j.bbrc.2009.02.102  0.88
2008 Taniguchi T, Fujino H, Israel DD, Regan JW, Murayama T. Human EP3(I) prostanoid receptor induces VEGF and VEGF receptor-1 mRNA expression. Biochemical and Biophysical Research Communications. 377: 1173-8. PMID 18996083 DOI: 10.1016/j.bbrc.2008.10.140  0.88
2008 Xu W, Chou CL, Sun H, Fujino H, Chen QM, Regan JW. FP prostanoid receptor-mediated induction of the expression of early growth response factor-1 by activation of a Ras/Raf/mitogen-activated protein kinase signaling cascade. Molecular Pharmacology. 73: 111-8. PMID 17911534 DOI: 10.1124/mol.107.038778  0.88
2007 Cherukuri DP, Chen XB, Goulet AC, Young RN, Han Y, Heimark RL, Regan JW, Meuillet E, Nelson MA. The EP4 receptor antagonist, L-161,982, blocks prostaglandin E2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells. Experimental Cell Research. 313: 2969-79. PMID 17631291 DOI: 10.1016/j.yexcr.2007.06.004  0.88
2007 Fujino H, Chen XB, Regan JW, Murayama T. Indomethacin decreases EP2 prostanoid receptor expression in colon cancer cells. Biochemical and Biophysical Research Communications. 359: 568-73. PMID 17555711 DOI: 10.1016/j.bbrc.2007.05.145  0.88
2007 Wada M, DeLong CJ, Hong YH, Rieke CJ, Song I, Sidhu RS, Yuan C, Warnock M, Schmaier AH, Yokoyama C, Smyth EM, Wilson SJ, FitzGerald GA, Garavito RM, Sui de X, ... Regan JW, et al. Enzymes and receptors of prostaglandin pathways with arachidonic acid-derived versus eicosapentaenoic acid-derived substrates and products. The Journal of Biological Chemistry. 282: 22254-66. PMID 17519235 DOI: 10.1074/jbc.M703169200  0.88
2006 Chen XB, Regan JW. Activation of the human FP prostanoid receptor disrupts mitosis progression and generates aneuploidy and polyploidy Cellular and Molecular Life Sciences. 63: 112-121. PMID 16378246 DOI: 10.1007/s00018-005-5303-0  0.88
2006 Fujino H, Regan JW. EP(4) prostanoid receptor coupling to a pertussis toxin-sensitive inhibitory G protein. Molecular Pharmacology. 69: 5-10. PMID 16204467 DOI: 10.1124/mol.105.017749  0.88
2005 Fujino H, Salvi S, Regan JW. Differential regulation of phosphorylation of the cAMP response element-binding protein after activation of EP2 and EP4 prostanoid receptors by prostaglandin E2. Molecular Pharmacology. 68: 251-9. PMID 15855407 DOI: 10.1124/mol.105.011833  0.88
2004 Fujino H, Vielhauer GA, Regan JW. Prostaglandin E2 selectively antagonizes prostaglandin F2alpha-stimulated T-cell factor/beta-catenin signaling pathway by the FPB prostanoid receptor. The Journal of Biological Chemistry. 279: 43386-91. PMID 15280380 DOI: 10.1074/jbc.M408276200  0.88
2004 Fujino H, Regan JW. Prostaglandin F2alpha amplifies tumor necrosis factor-alpha promoter activity by the FPB prostanoid receptor. Biochemical and Biophysical Research Communications. 317: 1114-20. PMID 15094384 DOI: 10.1016/j.bbrc.2004.03.167  0.88
2004 Vielhauer GA, Fujino H, Regan JW. Cloning and localization of hFP(S): a six-transmembrane mRNA splice variant of the human FP prostanoid receptor. Archives of Biochemistry and Biophysics. 421: 175-85. PMID 14984197 DOI: 10.1016/j.abb.2003.10.021  0.88
2003 Regan JW. EP2 and EP4 prostanoid receptor signaling. Life Sciences. 74: 143-53. PMID 14607241 DOI: 10.1016/j.lfs.2003.09.031  0.88
2003 Fujino H, Regan JW. Prostanoid receptors and phosphatidylinositol 3-kinase: a pathway to cancer? Trends in Pharmacological Sciences. 24: 335-40. PMID 12871665 DOI: 10.1016/S0165-6147(03)00162-7  0.88
2003 Fujino H, Regan JW. Prostaglandin F(2alpha) stimulation of cyclooxygenase-2 promoter activity by the FP(B) prostanoid receptor. European Journal of Pharmacology. 465: 39-41. PMID 12650831 DOI: 10.1016/S0014-2999(03)01485-7  0.88
2003 Fujino H, Xu W, Regan JW. Prostaglandin E2 induced functional expression of early growth response factor-1 by EP4, but not EP2, prostanoid receptors via the phosphatidylinositol 3-kinase and extracellular signal-regulated kinases. The Journal of Biological Chemistry. 278: 12151-6. PMID 12566441 DOI: 10.1074/jbc.M212665200  0.88
2003 Porter AC, Svensson SP, Stamer WD, Bahl JJ, Richman JG, Regan JW. Alpha-2 adrenergic receptors stimulate actin organization in developing fetal rat cardiac myocytes. Life Sciences. 72: 1455-66. PMID 12535714 DOI: 10.1016/S0024-3205(02)02381-0  0.88
2002 Weber TJ, Markillie LM, Chrisler WB, Vielhauer GA, Regan JW. Modulation of JB6 mouse epidermal cell transformation response by the prostaglandin F2alpha receptor. Molecular Carcinogenesis. 35: 163-72. PMID 12489107 DOI: 10.1002/mc.10079  0.88
2002 Fujino H, Srinivasan D, Regan JW. Cellular conditioning and activation of beta-catenin signaling by the FPB prostanoid receptor. The Journal of Biological Chemistry. 277: 48786-95. PMID 12368277 DOI: 10.1074/jbc.M209393200  0.88
2002 Srinivasan D, Fujino H, Regan JW. Differential internalization of the prostaglandin f(2alpha) receptor isoforms: role of protein kinase C and clathrin. The Journal of Pharmacology and Experimental Therapeutics. 302: 219-24. PMID 12065720 DOI: 10.1124/jpet.302.1.219  0.88
2002 Anthony TL, Fujino H, Pierce KL, Yool AJ, Regan JW. Differential regulation of Ca(2+)-dependent Cl- currents by FP prostanoid receptor isoforms in Xenopus oocytes. Biochemical Pharmacology. 63: 1797-806. PMID 12034364 DOI: 10.1016/S0006-2952(02)00953-X  0.88
2002 Huang Y, Stamer WD, Anthony TL, Kumar DV, St John PA, Regan JW. Expression of alpha(2)-adrenergic receptor subtypes in prenatal rat spinal cord. Brain Research. Developmental Brain Research. 133: 93-104. PMID 11882340 DOI: 10.1016/S0165-3806(02)00275-4  0.88
2002 Fujino H, West KA, Regan JW. Phosphorylation of glycogen synthase kinase-3 and stimulation of T-cell factor signaling following activation of EP2 and EP4 prostanoid receptors by prostaglandin E2. The Journal of Biological Chemistry. 277: 2614-9. PMID 11706038 DOI: 10.1074/jbc.M109440200  0.88
2001 Thompson EJ, Gupta A, Vielhauer GA, Regan JW, Bowden GT. The growth of malignant keratinocytes depends on signaling through the PGE(2) receptor EP1. Neoplasia (New York, N.Y.). 3: 402-10. PMID 11687951 DOI: 10.1038/sj.neo.7900182  0.88
2001 Ostrom RS, Gregorian C, Drenan RM, Xiang Y, Regan JW, Insel PA. Receptor number and caveolar co-localization determine receptor coupling efficiency to adenylyl cyclase. The Journal of Biological Chemistry. 276: 42063-9. PMID 11533056 DOI: 10.1074/jbc.M105348200  0.88
2001 Fujino H, Regan JW. FP Prostanoid Receptor Activation of a T-cell Factor/β-Catenin Signaling Pathway Journal of Biological Chemistry. 276: 12489-12492. PMID 11278257 DOI: 10.1074/jbc.C100039200  0.88
2000 Woodward DF, Krauss AH, Chen J, Gil DW, Kedzie KM, Protzman CE, Shi L, Chen R, Krauss HA, Bogardus A, Dinh HT, Wheeler LA, Andrews SW, Burk RM, Gac T, ... ... Regan JW, et al. Replacement of the carboxylic acid group of prostaglandin f(2alpha) with a hydroxyl or methoxy substituent provides biologically unique compounds. British Journal of Pharmacology. 130: 1933-43. PMID 10952685 DOI: 10.1038/sj.bjp.0703462  0.88
2000 Fujino H, Pierce KL, Srinivasan D, Protzman CE, Krauss AH, Woodward DF, Regan JW. Delayed reversal of shape change in cells expressing FP(B) prostanoid receptors. Possible role of receptor resensitization. The Journal of Biological Chemistry. 275: 29907-14. PMID 10893233 DOI: 10.1074/jbc.M003467200  0.88
2000 Anthony TL, Pierce KL, Regan JW. Characterization of ep prostanoid receptor subtypes in primary cultures of bovine ciliary epithelial cells by immunofluorescent microscopy and functional studies. Current Eye Research. 20: 394-404. PMID 10855034  0.88
2000 Brooks HL, Regan JW, Yool AJ. Inhibition of aquaporin-1 water permeability by tetraethylammonium: Involvement of the loop E pore region Molecular Pharmacology. 57: 1021-1026. PMID 10779387  0.88
2000 Anthony TL, Brooks HL, Boassa D, Leonov S, Yanochko GM, Regan JW, Yool AJ. Cloned human aquaporin-1 is a cyclic GMP-gated ion channel. Molecular Pharmacology. 57: 576-88. PMID 10692499  0.88
2000 Fujino H, Srinivasan D, Pierce KL, Regan JW. Differential regulation of prostaglandin F(2alpha) receptor isoforms by protein kinase C. Molecular Pharmacology. 57: 353-8. PMID 10648645  0.88
1999 Pierce KL, Fujino H, Srinivasan D, Regan JW. Activation of FP prostanoid receptor isoforms leads to Rho-mediated changes in cell morphology and in the cell cytoskeleton. The Journal of Biological Chemistry. 274: 35944-9. PMID 10585482 DOI: 10.1074/jbc.274.50.35944  0.88
1999 Fraeyman N, Vanscheeuwijck P, Wang JM, Huang Y, De Potter WP, Regan JW. Changes in the expression of a2-adrenergic receptor subtypes during maturation of neuronal cells from fetal pig superior cervical ganglia Developmental Brain Research. 116: 127-132. PMID 10521556 DOI: 10.1016/S0165-3806(99)00078-4  0.88
1999 Hoyer PB, Marion SL, Stine I, Rueda BR, Hamernik DL, Regan JW, Wise ME. Ovine prostaglandin F2alpha receptor: steroid influence on steady-state levels of luteal mRNA. Endocrine. 10: 105-11. PMID 10451218 DOI: 10.1385/ENDO:10:2:105  0.88
1998 Kedzie KM, Donello JE, Krauss HA, Regan JW, Gil DW. A single amino-acid substitution in the EP2 prostaglandin receptor confers responsiveness to prostacyclin analogs Molecular Pharmacology. 54: 584-590. PMID 9730918  0.88
1998 Pierce KL, Regan JW. Prostanoid receptor heterogeneity through alternative mRNA splicing. Life Sciences. 62: 1479-83. PMID 9585122 DOI: 10.1016/S0024-3205(98)00093-9  0.88
1998 Richman JG, Regan JW. α2-adrenergic receptors increase cell migration and decrease F-actin labeling in rat aortic smooth muscle cells American Journal of Physiology - Cell Physiology. 274: C654-C662. PMID 9530096  0.88
1998 Anthony TL, Pierce KL, Stamer WD, Regan JW. Prostaglandin F2 alpha receptors in the human trabecular meshwork. Investigative Ophthalmology & Visual Science. 39: 315-21. PMID 9477988  0.88
1998 Regan JW, Richman JG. α2-Adrenergic receptors stimulate cell migration and decrease cytoskeletal organization in rat aortic smooth muscle cells Faseb Journal. 12: A700.  0.88
1997 LeVan TD, Dow SB, Chase PB, Bloom JW, Regan JW, Cunningham E, Halonen M. Evidence for platelet-activating factor receptor subtypes on human polymorphonuclear leukocyte membranes. Biochemical Pharmacology. 54: 1007-12. PMID 9374421 DOI: 10.1016/S0006-2952(97)00249-9  0.88
1997 Svensson SPS, Porter AC, Regan JW. Cloning and functional expression of guinea pig atrial α2-adrenergic receptor subtypes Annals of the New York Academy of Sciences. 812: 171-173. PMID 9186732 DOI: 10.1111/j.1749-6632.1997.tb48162.x  0.88
1997 Woodward DF, Regan JW, Lake S, Ocklind A. The molecular biology and ocular distribution of prostanoid receptors Survey of Ophthalmology. 41: S15-S21. PMID 9154272  0.88
1997 Agre P, Lee MD, Devidas S, Guggino WB. Aquaporins and ion conductance. Science (New York, N.Y.). 275: 1490; author reply 1. PMID 9045617 DOI: 10.1126/science.275.5305.1490  0.88
1997 Pierce KL, Bailey TJ, Hoyer PB, Gil DW, Woodward DF, Regan JW. Cloning of a carboxyl-terminal isoform of the prostanoid FP receptor. The Journal of Biological Chemistry. 272: 883-7. PMID 8995377 DOI: 10.1074/jbc.272.2.883  0.88
1996 Chase PB, Yang JM, Thompson FH, Halonen M, Regan JW. Regional mapping of the human platelet-activating factor receptor gene (PTAFR) to 1p35-->p34.3 by fluorescence in situ hybridization. Cytogenetics and Cell Genetics. 72: 205-7. PMID 8978777  0.88
1996 Stamer WD, Snyder RW, Regan JW. Characterization of the transmembrane orientation of aquaporin-1 using antibodies to recombinant fusion proteins. Biochemistry. 35: 16313-8. PMID 8973206 DOI: 10.1021/bi9619536  0.88
1996 Stamer WD, Huang Y, Seftor RE, Svensson SS, Snyder RW, Regan JW. Cultured human trabecular meshwork cells express functional alpha 2A adrenergic receptors. Investigative Ophthalmology & Visual Science. 37: 2426-33. PMID 8933759  0.88
1996 Yool AJ, Stamer WD, Regan JW. Forskolin stimulation of water and cation permeability in aquaporin 1 water channels. Science (New York, N.Y.). 273: 1216-8. PMID 8703053  0.88
1996 Svensson SPS, Bailey TJ, Porter AC, Richman JG, Regan JW. Heterologous expression of the cloned guinea pig α2A, α2B, and α2C adrenoceptor subtypes: Radioligand binding and functional coupling to a cAMP-responsive reporter gene Biochemical Pharmacology. 51: 291-300. PMID 8573196 DOI: 10.1016/0006-2952(95)02179-5  0.88
1996 Pierce KL, Yool AJ, Moyer PB, Gil DW, Woodward DE, Regan JW. Cloning of a novel isoform of the sheep FP prostaglandin receptor Proceedings of the Western Pharmacology Society. 39: 104.  0.88
1996 Stamer WD, Snyder RW, Burkey TH, Regan JW. Activation of α2A-adrenergic receptors in human trabecular meshwork cells stimulates MAP kinase activity Investigative Ophthalmology and Visual Science. 37: S206.  0.88
1995 Rueda BR, Botros IW, Pierce KL, Regan JW, Hoyer PB. Comparison of mRNA levels for the PGF(2α) receptor (FP) during luteolysis and early pregnancy in the ovine corpus luteum. Endocrine. 3: 781-7. PMID 21153121 DOI: 10.1007/BF02935681  0.88
1995 Stamer WD, Seftor RE, Snyder RW, Regan JW. Cultured human trabecular meshwork cells express aquaporin-1 water channels. Current Eye Research. 14: 1095-1100. PMID 8974838 DOI: 10.3109/02713689508995815  0.88
1995 Woodward DF, Bogardus AM, Donello JE, Fairbairn CE, Gil DW, Kedzie KM, Burke JA, Kharlamb A, Runde E, Andrews SW, Pierce KL, Regan JW. Molecular characterization and ocular hypotensive properties of the prostanoid EP2 receptor Journal of Ocular Pharmacology and Therapeutics. 11: 447-454. PMID 8590276  0.88
1995 Burkey TH, Regan JW. Activation of Mitogen-Activated Protein Kinase by the Human Prostaglandin EP3A Receptor Biochemical and Biophysical Research Communications. 211: 152-158. PMID 7779081 DOI: 10.1006/bbrc.1995.1790  0.88
1995 Graves PE, Pierce KL, Bailey TJ, Rueda BR, Gil DW, Woodward DF, Yool AJ, Hoyer PB, Regan JW. Cloning of a receptor for prostaglandin F2 alpha from the ovine corpus luteum. Endocrinology. 136: 3430-6. PMID 7628379 DOI: 10.1210/endo.136.8.7628379  0.88
1995 Bylund DB, Regan JW, Faber JE, Hieble JP, Triggle CR, Ruffolo RR. Vascular alpha-adrenoceptors: from the gene to the human. Canadian Journal of Physiology and Pharmacology. 73: 533-43. PMID 7585318 DOI: 10.1139/y95-068  0.88
1995 Woodward DF, Pepperl DJ, Burkey TH, Regan JW. 6-isopropoxy-9-oxoxanthene-2-carboxylic acid (AH 6809), a human EP2 receptor antagonist Biochemical Pharmacology. 50: 1731-1733. PMID 7503778 DOI: 10.1016/0006-2952(95)02035-7  0.88
1995 Huang Y, Gil DW, Vanscheeuwijck P, Stamer WD, Regan JW. Localization of alpha 2-adrenergic receptor subtypes in the anterior segment of the human eye with selective antibodies. Investigative Ophthalmology & Visual Science. 36: 2729-39. PMID 7499095  0.88
1995 Pierce KL, Gil DW, Woodward DF, Regan JW. Cloning of human prostanoid receptors. Trends in Pharmacological Sciences. 16: 253-6. PMID 7482980 DOI: 10.1016/S0165-6147(00)89035-5  0.88
1994 Regan JW, Bailey TJ, Pepperl DJ, Pierce KL, Bogardus AM, Donello JE, Fairbairn CE, Kedzie KM, Woodward DF, Gil DW. Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype. Molecular Pharmacology. 46: 213-20. PMID 8078484  0.88
1994 Regan JW, Bailey TJ, Donello JE, Pierce KL, Pepperl DJ, Zhang D, Kedzie KM, Fairbairn CE, Bogardus AM, Woodward DF. Molecular cloning and expression of human EP3 receptors: evidence of three variants with differing carboxyl termini. British Journal of Pharmacology. 112: 377-85. PMID 8075855 DOI: 10.1111/j.1476-5381.1994.tb13082.x  0.4
1994 Stamer WD, Snyder RW, Smith BL, Agre P, Regan JW. Localization of aquaporin CHIP in the human eye: implications in the pathogenesis of glaucoma and other disorders of ocular fluid balance. Investigative Ophthalmology & Visual Science. 35: 3867-72. PMID 7523327  0.88
1994 Chase PB, Regan JW, Halonen M. Evidence for an intron in the 5'-untranslated region of a human PAF receptor gene Journal of Lipid Mediators and Cell Signalling. 10: 81-82.  0.88
1993 Chase PB, Halonen M, Regan JW. Cloning of a human platelet-activating factor receptor gene: evidence for an intron in the 5'-untranslated region. American Journal of Respiratory Cell and Molecular Biology. 8: 240-4. PMID 8383507 DOI: 10.1165/ajrcmb/8.3.240  0.88
1993 Vanscheeuwijck P, Huang Y, Schullery D, Regan JW. Antibodies to a Human α2-C10 Adrenergic Receptor Fusion Protein Confirm the Cytoplasmic Orientation of the V-VI Loop Biochemical and Biophysical Research Communications. 190: 340-346. PMID 8381272 DOI: 10.1006/bbrc.1993.1053  0.88
1993 Huang Y, Vanscheeuwijck P, Regan JW. Precipitation with KCl improves the chemical cross-linking of GST-fusion proteins to agarose after solubilization with SDS Biotechniques. 15: 987+989+992. PMID 8292352  0.88
1993 Agarwal A, Pearson PP, Taylor EW, Li HB, Dahlgren T, Herslöf M, Yang Y, Lambert G, Nelson DL, Regan JW. Three-dimensional quantitative structure-activity relationships of 5-HT receptor binding data for tetrahydropyridinylindole derivatives: a comparison of the Hansch and CoMFA methods. Journal of Medicinal Chemistry. 36: 4006-14. PMID 8258822  0.88
1993 Pepperl DJ, Regan JW. Selective coupling of α2-adrenergic receptor subtypes to cyclic AMP-dependent reporter gene expression in transiently transfected JEG-3 cells Molecular Pharmacology. 44: 802-809. PMID 8232231  0.88
1993 Svensson SPS, Bailey TJ, Pepperl DJ, Grundstrom N, Ala-Uotila S, Scheinin M, Karlsson JOG, Regan JW. Cloning and expression of a fish α2-adrenoceptor British Journal of Pharmacology. 110: 54-60. PMID 7693288  0.88
1992 Sun L, Schulte N, Pettinger P, Regan JW, Pettinger WA. The frequency of α2-adrenoceptor restriction fragment length polymorphisms in normotensive and hypertensive humans Journal of Hypertension. 10: 1011-1015. PMID 1357028  0.88
1992 Perälä M, Hirvonen H, Kalimo H, Ala-Uotila S, Regan JW, Akerman KE, Scheinin M. Differential expression of two alpha 2-adrenergic receptor subtype mRNAs in human tissues. Brain Research. Molecular Brain Research. 16: 57-63. PMID 1334200 DOI: 10.1016/0169-328X(92)90193-F  0.88
1992 Marjamäki A, Ala-Uotila S, Luomala K, Perälä M, Jansson C, Jalkanen M, Regan JW, Scheinin M. Stable expression of recombinant human α2-adrenoceptor subtypes in two mammalian cell lines: characterization with [3H]rauwolscine binding, inhibition of adenylate cyclase and RNase protection assay Bba - Molecular Cell Research. 1134: 169-177. PMID 1313304 DOI: 10.1016/0167-4889(92)90041-9  0.88
1991 Kurose H, Regan JW, Caron MG, Lefkowitz RJ. Functional interactions of recombinant alpha 2 adrenergic receptor subtypes and G proteins in reconstituted phospholipid vesicles. Biochemistry. 30: 3335-41. PMID 1849000 DOI: 10.1021/bi00227a024  0.48
1991 Kedzie KM, Balfour CA, Escobar GY, Grimm SW, He YA, Pepperl DJ, Regan JW, Stevens JC, Halpert JR. Molecular basis for a functionally unique cytochrome P450IIB1 variant. The Journal of Biological Chemistry. 266: 22515-21. PMID 1718996  0.88
1991 Maze M, Regan JW. Role of signal transduction in anesthetic action. α2 adrenergic agonists Annals of the New York Academy of Sciences. 625: 409-422. PMID 1711813 DOI: 10.1111/j.1749-6632.1991.tb33868.x  0.88
1991 Parola AL, Stump DG, Pepperl DJ, Krueger KE, Regan JW, Laird HE. Cloning and expression of a pharmacologically unique bovine peripheral-type benzodiazepine receptor isoquinoline binding protein. The Journal of Biological Chemistry. 266: 14082-7. PMID 1649835  0.88
1991 Onorato JJ, Palczewski K, Regan JW, Caron MG, Lefkowitz RJ, Benovic JL. Role of acidic amino acids in peptide substrates of the β-adrenergic receptor kinase and rhodopsin kinase Biochemistry®. 30: 5118-5125. PMID 1645191  0.88
1990 Lorenz W, Lomasney JW, Collins S, Regan JW, Caron MG, Lefkowitz RJ. Expression of three α2-adrenergic receptor subtypes in rat tissues: Implications for α2 receptor classification Molecular Pharmacology. 38: 599-603. PMID 2172770  0.88
1990 Lomasney JW, Lorenz W, Allen LF, Klng K, Regan JW, Yang-Fengh TL, Caron MG, Lefkowitz RJ. Expansion of the α2-adrenergic receptor family: Cloning and characterization of a human α2-adrenergic receptor subtype, the gene for which is located on chromosome 2 Proceedings of the National Academy of Sciences of the United States of America. 87: 5094-5098. PMID 2164221  0.88
1990 Michel MC, Regan JW, Gerhardt MA, Neubig RR, Insel PA, Motulsky HJ. Nonadrenergic [3H]idazoxan binding sites are physically distinct from alpha 2-adrenergic receptors. Molecular Pharmacology. 37: 65-8. PMID 2153910  0.88
1990 Cotecchia S, Kobilka BK, Daniel KW, Nolan RD, Lapetina EY, Caron MG, Lefkowitz RJ, Regan JW. Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells. The Journal of Biological Chemistry. 265: 63-9. PMID 2152928  0.88
1990 Seuwen K, Magnaldo I, Kobilka BK, Caron MG, Regan JW, Lefkowitz RJ, Pouysségur J. Alpha 2-adrenergic agonists stimulate DNA synthesis in Chinese hamster lung fibroblasts transfected with a human alpha 2-adrenergic receptor gene. Cell Regulation. 1: 445-51. PMID 1981685  0.88
1990 Seuwen K, Magnaldo I, Kobilka BK, Caron MG, Regan JW, Lefkowitz RJ, Pouysségur J. α2-Adrenergic agonists stimulate DNA synthesis in Chinese hamster lung fibroblasts transfected with a human α2-adrenergic receptor gene Molecular Biology of the Cell. 1: 445-451.  0.88
1989 Fargin A, Raymond JR, Regan JW, Cotecchia S, Lefkowitz RJ, Caron MG. Effector coupling mechanisms of the cloned 5-HT1A receptor Journal of Biological Chemistry. 264: 14848-14852. PMID 2549039  0.88
1989 Matsui H, Lefkowitz RJ, Caron MG, Regan JW. Localization of the fourth membrane spanning domain as a ligand binding site in the human platelet α2-adrenergic receptor Biochemistry. 28: 4125-4130. PMID 2546589  0.88
1989 Catterall WA, Kobilka BK, Kobilka TS, Daniels KW, Regan JW, Caran MG, Lefkowitz RJ. Analysis of ligand binding specificity of receptor chimeras Science. 243: 236-237. PMID 2536189 DOI: 10.1126/SCIENCE.2536189  0.88
1989 Raymond JR, Fargin A, Lohse MJ, Regan JW, Senogles SE, Lefkowitz RJ, Caron MG. Identification of the ligand-binding subunit of the human 5-hydroxytryptamine1A receptor with N-(p-azido-m-[125I] iodophenethyl)spiperone, a high affinity radioiodinated photoaffinity probe. Molecular Pharmacology. 36: 15-21. PMID 2526292  0.88
1988 Daly RN, Sulpizio AC, Levitt B, DeMarinis RM, Regan JW, Ruffolo RR, Hieble JP. Evidence for heterogeneity between pre- and postjunctional alpha-2 adrenoceptors using 9-substituted 3-benzazepines Journal of Pharmacology and Experimental Therapeutics. 247: 122-128. PMID 2902209  0.88
1988 Lefkowitz RJ, Kobilka BK, Benovic JL, Bouvier M, Cotecchia S, Hausdorff WP, Dohlman HG, Regan JW, Caron MG. Molecular biology of adrenergic receptors. Cold Spring Harbor Symposia On Quantitative Biology. 53: 507-14. PMID 2855490  0.88
1988 O'Dowd BF, Hnatowich M, Regan JW, Leader WM, Caron MG, Lefkowitz RJ. Site-directed mutagenesis of the cytoplasmic domains of the human β2-adrenergic receptor. Localization of regions involved in G protein-receptor coupling Journal of Biological Chemistry. 263: 15985-15992. PMID 2846532  0.88
1988 Regan JW, Kobilka TS, Yang-Feng TL, Caron MG, Lefkowitz RJ, Kobilka BK. Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype. Proceedings of the National Academy of Sciences of the United States of America. 85: 6301-5. PMID 2842764  0.88
1988 Kobilka BK, Kobilka TS, Daniel K, Regan JW, Caron MG, Lefkowitz RJ. Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity. Science (New York, N.Y.). 240: 1310-6. PMID 2836950  0.88
1987 Benovic JL, Regan JW, Matsui H, Mayor F, Cotecchia S, Leeb-Lundberg LMF, Caron MG, Lefkowitz RJ. Agonist-dependent phosphorylation of the α2-adrenergic receptor by the β-adrenergic receptor kinase Journal of Biological Chemistry. 262: 17251-17253. PMID 2826414  0.88
1987 Kobilka BK, Matsui H, Kobilka TS, Yang-Feng TL, Francke U, Caron MG, Lefkowitz RJ, Regan JW. Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor. Science (New York, N.Y.). 238: 650-6. PMID 2823383  0.88
1986 Hiroyasu N, Regan JW, Lefkowitz RJ. Chemical modification of α2-adrenoceptors. Possible role for tyrosine in the ligand binding site Biochemical Pharmacology. 35: 4089-4094. PMID 3022750 DOI: 10.1016/0006-2952(86)90033-X  0.88
1986 Regan JW, Raymond JR, Lefkowitz RJ, DeMarinis RM. Photoaffinity labeling of human platelet and rabbit kidney α2-adrenoceptors with [3H]SKF 102229 Biochemical and Biophysical Research Communications. 137: 606-613. PMID 3015124 DOI: 10.1016/0006-291X(86)91121-6  0.88
1986 Lomasney JW, Leeb-Lundberg LMF, Cotecchia S, Regan JW, DeBernardis JF, Caron MG, Lefkowitz RJ. Mammalian α1-adrenergic receptor. Purification and characterization of the native receptor ligand binding subunit Journal of Biological Chemistry. 261: 7710-7716. PMID 3011796  0.88
1986 Cerione RA, Regan JW, Nakata H, Codina J, Benovic JL, Gierschik P, Somers RL, Spiegel AM, Birnbaumer L, Lefkowitz RJ. Functional reconstitution of the alpha 2-adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles. The Journal of Biological Chemistry. 261: 3901-9. PMID 3005307  0.88
1986 Regan JW, Nakata H, DeMarinis RM, Caron MG, Lefkowitz RJ. Purification and characterization of the human platelet α2-adrenergic receptor Journal of Biological Chemistry. 261: 3894-3900. PMID 3005306  0.88
1985 Regan JW, DeMarinis RM, Lefkowitz RJ. Arylazide photoaffinity probe for α2-adrenoceptors Biochemical Pharmacology. 34: 3667-3672. PMID 2864929 DOI: 10.1016/0006-2952(85)90228-X  0.88
1984 DeMarinis RM, Krog AJ, Shah DH, Lafferty J, Holden KG, Hieble JP, Matthews WD, Regan JW, Lefkowitz RJ, Caron MG. Development of an affinity ligand for purification of α2-adrenoceptors from human platelet membranes Journal of Medicinal Chemistry. 27: 918-921. PMID 6330361  0.88
1984 Regan JW, DeMarinis RM, Caron MG, Lefkowitz RJ. Identification of the subunit-binding site of α2-adrenergic receptors using [3H]phenoxybenzamine Journal of Biological Chemistry. 259: 7864-7869. PMID 6330087  0.88
1982 Regan JW, Barden N, Lefkowitz RJ, Caron MG, DeMarinis RM, Krog AJ, Holden KG, Matthews WD, Hieble JP. Affinity chromatography of human platelet α 2-adrenergic receptors Proceedings of the National Academy of Sciences of the United States of America. 79: 7223-7227. PMID 6130523 DOI: 10.1073/pnas.79.23.7223  0.88
1981 Regan JW, Roeske WR, Malick JB, Yamamura SH, Yamamura HI. γ-Aminobutyric acid enhancement of CL 218,872 affinity and evidence of benzodiazepine receptor heterogeneity Molecular Pharmacology. 20: 477-483. PMID 6276709  0.88
1981 Regan JW, Roeske WR, Ruth WH, Deshmukh P, Yamamura HI. Reductions in retinal γ-aminobutyric acid (GABA) content and in [ 3H]flunitrazepam binding after postnatal monosodium glutamate injections in rats Journal of Pharmacology and Experimental Therapeutics. 218: 791-796. PMID 6267248  0.88
1981 Regan JW, Yamamura HI, Yamada S, Roeske WR. High affinity renal [3H]flunitrazepam binding: Characterization, localization, and alteration in hypertension Life Sciences. 28: 991-998. PMID 6111733 DOI: 10.1016/0024-3205(81)90744-X  0.88
1981 Regan JW, Roeske WR, Ruth W. Reductions in benzodiazepine binding following postnatal monosodium glutamate injections in rats Federation Proceedings. 40: 434.  0.88
1980 Regan JW, Yamamura HI, Yamada S, Roeske WR. Renal benzodiazepine binding increases during deoxycorticosterone/salt hypertension in rats European Journal of Pharmacology. 67: 167-168. PMID 7418732 DOI: 10.1016/0014-2999(80)90029-1  0.88
1980 Regan JW, Roeske WR, Yamamura HI. The benzodiazepine receptor: Its development and its modulation by γ-aminobutyric acid Journal of Pharmacology and Experimental Therapeutics. 212: 137-143. PMID 7351621  0.88
1980 Regan JW, Morris MM, Nao B, Bjeldanes LF. Metabolism of limonene-1,2-epoxide in the rat Xenobiotica. 10: 859-861. PMID 7210698 DOI: 10.3109/00498258009033819  0.88
1980 Regan JW, Roeske WR, Yamamura HI. 3H-flunitrazepam binding to bovine retina and the effect of GABA thereon Neuropharmacology. 19: 413-414. PMID 6104311 DOI: 10.1016/0028-3908(80)90195-1  0.88
1980 Regan JW, Roeske WR, Yamamura HI. The effect of GABA on the binding of 3H-flunitrazepam in mouse brains during development Brain Research Bulletin. 5: 857-860. DOI: 10.1016/0361-9230(80)90144-6  0.88
1976 Regan JW, Bjeldanes LF. Metabolism of (+)-limonene in rats Journal of Agricultural and Food Chemistry. 24: 377-380. PMID 815305  0.88
1974 Mainoya JR, Bern HA, Regan JW. Influence of ovine prolactin on transport of fluid and sodium chloride by the mammalian intestine and gall bladder Journal of Endocrinology. 63: 311-317. PMID 4443693  0.88
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