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Leslie Z. Benet - Publications

Affiliations: 
Bioengineering University of California, San Francisco, San Francisco, CA 
Area:
Pharmacy
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Year Citation  Score
2022 Bocci G, Oprea TI, Benet LZ. State of the Art and Uses for the Biopharmaceutics Drug Disposition Classification System (BDDCS): New Additions, Revisions, and Citation References. The Aaps Journal. 24: 37. PMID 35199251 DOI: 10.1208/s12248-022-00687-0  0.339
2020 Benet LZ, Sodhi JK. Investigating the Theoretical Basis for In Vitro-In Vivo Extrapolation (IVIVE) in Predicting Drug Metabolic Clearance and Proposing Future Experimental Pathways. The Aaps Journal. 22: 120. PMID 32914238 DOI: 10.1208/S12248-020-00501-9  0.399
2020 Sodhi JK, Benet LZ. The Necessity of Using Changes in Absorption Time to Implicate Intestinal Transporter Involvement in Oral Drug-Drug Interactions. The Aaps Journal. 22: 111. PMID 32808084 DOI: 10.1208/S12248-020-00469-6  0.435
2020 Di L, Artursson P, Avdeef A, Benet L, Houston B, Kansy M, Kerns E, Lennernäs H, Smith D, Sugano K. The Critical Role of Passive Permeability in Designing Successful Drugs. Chemmedchem. PMID 32743945 DOI: 10.1002/Cmdc.202000419  0.402
2020 Sodhi JK, Huang CH, Benet LZ. Volume of Distribution is Unaffected by Metabolic Drug-Drug Interactions. Clinical Pharmacokinetics. PMID 32725383 DOI: 10.1007/S40262-020-00926-7  0.414
2020 Sodhi JK, Wang HJ, Benet LZ. Are there any experimental perfusion data that preferentially support the dispersion and parallel tube models over the well-stirred model of organ elimination? Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 32305951 DOI: 10.1124/Dmd.120.090530  0.383
2020 Sodhi JK, Liu S, Benet LZ. Challenging the Relevance of Unbound Tissue-to-Blood Partition Coefficient (Kp) on Prediction of Drug-Drug Interactions. Pharmaceutical Research. 37: 73. PMID 32215750 DOI: 10.1007/S11095-020-02797-W  0.394
2020 Sodhi JK, Benet LZ. A Simple Methodology to Differentiate Changes in Bioavailability from Changes in Clearance Following Oral Dosing of Metabolized Drugs. Clinical Pharmacology and Therapeutics. PMID 32150643 DOI: 10.1002/Cpt.1828  0.414
2020 Liu W, Yan T, Chen K, Yang L, Benet L, Zhai S. Predicting Interactions between Rifampin and Antihypertensive Drugs Using the Biopharmaceutics Drug Disposition Classification System (BDDCS). Pharmacotherapy. PMID 32100890 DOI: 10.1002/Phar.2380  0.395
2020 Sun A, Benet LZ. Late-Stage Failures of Monoclonal Antibody Drugs: A Retrospective Case Study Analysis. Pharmacology. 1-19. PMID 31910414 DOI: 10.1159/000505379  0.325
2019 Bocci G, Benet LZ, Oprea TI. Can BDDCS illuminate targets in drug design? Drug Discovery Today. PMID 31585170 DOI: 10.1016/J.Drudis.2019.09.021  0.384
2019 Wang HJ, Benet LZ. Protein binding and hepatic clearance: Re-examining the discrimination between models of hepatic clearance with diazepam in the isolated perfused rat liver preparation. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 31563869 DOI: 10.1124/Dmd.119.088872  0.329
2019 Bowman CM, Benet LZ. In Vitro - In Vivo Accuracy: The CYP3A4 Anomaly. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 31551322 DOI: 10.1124/Dmd.119.088427  0.339
2019 Benet LZ, Bowman CM, Sodhi JK. How Transporters Have Changed Basic Pharmacokinetic Understanding. The Aaps Journal. 21: 103. PMID 31482335 DOI: 10.1208/S12248-019-0373-3  0.411
2019 Moriya Y, Kogame A, Tagawa Y, Morohashi A, Kondo T, Asahi S, Benet LZ. The enhancement of subcutaneous first-pass metabolism causes non-linear pharmacokinetics of TAK-448 after a single subcutaneous administration to rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 31201213 DOI: 10.1124/Dmd.119.087148  0.358
2019 Benet LZ, Bowman CM, Koleske ML, Rinaldi CL, Sodhi JK. Understanding drug-drug interaction and pharmacogenomic changes in pharmacokinetics for metabolized drugs. Journal of Pharmacokinetics and Pharmacodynamics. PMID 30911879 DOI: 10.1007/S10928-019-09626-7  0.459
2019 Bowman CM, Benet LZ. In vitro-in vivo extrapolation and hepatic clearance dependent underprediction. Journal of Pharmaceutical Sciences. PMID 30817922 DOI: 10.1016/J.Xphs.2019.02.009  0.32
2019 Kogame A, Moriya Y, Mori I, Pan L, Morohashi A, Ebihara T, Fukui H, Tagawa Y, Benet LZ. Characterization of fasiglifam-related liver toxicity in dogs. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 30765394 DOI: 10.1124/Dmd.118.084889  0.32
2019 Bowman CM, Okochi H, Benet LZ. The Presence of a Transporter-Induced Protein Binding Shift: A new Explanation for Protein-Facilitated Uptake and Improvement for In Vitro-In Vivo Extrapolation. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 30674616 DOI: 10.1124/Dmd.118.085779  0.359
2019 Jayachandran P, Okochi H, Frassetto LA, Park W, Fang L, Zhao L, Benet LZ. Evaluating Within-Subject Variability for Narrow Therapeutic Index Drugs. Clinical Pharmacology and Therapeutics. PMID 30652304 DOI: 10.1002/Cpt.1293  0.391
2018 Wolfe AR, Neitz RJ, Burlingame M, Suzuki BM, Lim KC, Scheideler M, Nelson DL, Benet LZ, Caffrey CR. TPT sulfonate, a single, oral dose schistosomicidal prodrug: In vivo efficacy, disposition and metabolic profiling. International Journal For Parasitology. Drugs and Drug Resistance. 8: 571-586. PMID 30503203 DOI: 10.1016/J.Ijpddr.2018.10.004  0.333
2018 Bowman CM, Benet LZ. An examination of protein binding and protein-facilitated uptake relating to in vitro-in vivo extrapolation. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 123: 502-514. PMID 30098391 DOI: 10.1016/J.Ejps.2018.08.008  0.332
2018 Chan R, Benet LZ. Evaluation of the Relevance of DILI Predictive Hypotheses in Early Drug Development: Review of Methodologies BDDCS Classification. Toxicology Research. 7: 358-370. PMID 29785262 DOI: 10.1039/C8Tx00016F  0.436
2018 Benet LZ. Predicting Pharmacokinetics/Pharmacodynamics in the Individual Patient: Separating Reality From Hype. Journal of Clinical Pharmacology. PMID 29663413 DOI: 10.1002/Jcph.1105  0.443
2018 Liu W, Guan X, Yu Z, Chen K, Benet L, Zhai S. A Drug-drug Interaction Between Cyclosporine and Nystatin. Clinical Therapeutics. PMID 29551534 DOI: 10.1016/J.Clinthera.2018.02.008  0.406
2018 Parasrampuria DA, Benet LZ, Sharma A. Why Drugs Fail in Late Stages of Development: Case Study Analyses from the Last Decade and Recommendations. The Aaps Journal. 20: 46. PMID 29536211 DOI: 10.1208/S12248-018-0204-Y  0.346
2018 Phung N, Kuncze K, Okochi H, Louie A, Benet LZ, Ofokotun I, Haas DW, Currier JS, Chawana TD, Sheth AN, Bacchetti P, Gandhi M, Horng H. Development and Validation of an Assay to Analyze Atazanavir in Human Hair Via Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS). Rapid Communications in Mass Spectrometry : Rcm. PMID 29315954 DOI: 10.1002/Rcm.8058  0.714
2018 Benet LZ. The application of BCS and BDDCS in drug discovery and development Drug Metabolism and Pharmacokinetics. 33: S2. DOI: 10.1016/J.Dmpk.2017.11.014  0.374
2017 Chan R, Benet LZ. Measures of BSEP Inhibition In Vitro Are Not Useful Predictors of DILI. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 29272540 DOI: 10.1093/Toxsci/Kfx284  0.425
2017 Koss CA, Hosek SG, Bacchetti P, Anderson PL, Liu AY, Horng H, Benet LZ, Kuncze K, Louie A, Saberi P, Wilson CM, Gandhi M. Comparison of Measures of Adherence to HIV Preexposure Prophylaxis among Adolescent and Young Men Who Have Sex with Men in the United States. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. PMID 29020194 DOI: 10.1093/Cid/Cix755  0.67
2017 Benet LZ, Liu S, Wolfe AR. The Universally Unrecognized Assumption in Predicting Drug Clearance and Organ Extraction Ratio. Clinical Pharmacology and Therapeutics. 103: 521-525. PMID 28762489 DOI: 10.1002/Cpt.802  0.355
2017 Noguchi S, Nishimura T, Mukaida S, Benet LZ, Nakashima E, Tomi M. Cellular Uptake of Levocetirizine by Organic Anion Transporter 4. Journal of Pharmaceutical Sciences. PMID 28385546 DOI: 10.1016/J.Xphs.2017.03.026  0.313
2017 Wu HF, Hristeva N, Chang J, Liang X, Li R, Frassetto L, Benet LZ. Rosuvastatin Pharmacokinetics in Asian and White Subjects wild-type for Both OATP1B1 and BCRP Under Control and Inhibited Conditions. Journal of Pharmaceutical Sciences. PMID 28385543 DOI: 10.1016/J.Xphs.2017.03.027  0.309
2017 Chan R, Benet LZ. Evaluation of DILI Predictive Hypotheses in Early Drug Development. Chemical Research in Toxicology. PMID 28257576 DOI: 10.1021/Acs.Chemrestox.7B00025  0.424
2017 Koss CA, Bacchetti P, Hillier SL, Livant E, Horng H, Mgodi N, Mirembe BG, Gomez Feliciano K, Horn S, Liu AY, Glidden DV, Grant RM, Benet LZ, Louie A, van der Straten A, et al. Differences in Cumulative Exposure and Adherence to Tenofovir in the VOICE, iPrEx OLE, and PrEP Demo Studies as Determined via Hair Concentrations. Aids Research and Human Retroviruses. PMID 28253024 DOI: 10.1089/aid.2016.0202  0.697
2016 Li J, Larregieu CA, Benet LZ. Classification of natural products as sources of drugs according to the biopharmaceutics drug disposition classification system (BDDCS). Chinese Journal of Natural Medicines. 14: 888-897. PMID 28262115 DOI: 10.1016/S1875-5364(17)30013-4  0.793
2016 Faber KP, Wu HF, Yago MR, Xu X, Kadiyala P, Frassetto LA, Benet LZ. Meal Effects Confound Attempts to Counteract Rabeprazole-Induced Hypochlorhydria Decreases in Atazanavir Absorption. Pharmaceutical Research. PMID 28028768 DOI: 10.1007/S11095-016-2090-2  0.343
2016 Gandhi M, Glidden DV, Mayer K, Schechter M, Buchbinder S, Grinsztejn B, Hosek S, Casapia M, Guanira J, Bekker LG, Louie A, Horng H, Benet LZ, Liu A, Grant RM. Association of age, baseline kidney function, and medication exposure with declines in creatinine clearance on pre-exposure prophylaxis: an observational cohort study. The Lancet. Hiv. PMID 27658870 DOI: 10.1016/S2352-3018(16)30153-9  0.689
2016 Bowman CM, Benet LZ. Hepatic clearance predictions from in vitro-in vivo extrapolation and BDDCS. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 27519549 DOI: 10.1124/Dmd.116.071514  0.389
2016 Benet LZ, Hosey CM, Ursu O, Oprea TI. BDDCS, the Rule of 5 and drugability. Advanced Drug Delivery Reviews. PMID 27182629 DOI: 10.1016/J.Addr.2016.05.007  0.341
2016 Mave V, Chandanwale A, Kinikar A, Khadse S, Kagal A, Gupte N, Suryavanshi N, Nimkar S, Koli H, Khwaja S, Bharadwaj R, Joshi S, Horng H, Benet LZ, Ramachandran G, et al. Isoniazid hair concentrations in children with tuberculosis: a proof of concept study. The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease. 20: 844-847. PMID 27155191 DOI: 10.5588/Ijtld.15.0882  0.719
2016 Chan R, Wei CY, Chen YT, Benet LZ. Use of the Biopharmaceutics Drug Disposition Classification System (BDDCS) to Help Predict the Occurrence of Idiosyncratic Cutaneous Adverse Drug Reactions Associated with Antiepileptic Drug Usage. The Aaps Journal. PMID 26951484 DOI: 10.1208/S12248-016-9898-X  0.313
2016 Estudante M, Soveral G, Morais JG, Benet LZ. Insights into solute carriers: physiological functions and implications in disease and pharmacokinetics Medchemcomm. 7: 1462-1478. DOI: 10.1039/C6Md00188B  0.412
2015 Hosey CM, Chan R, Benet LZ. BDDCS Predictions, Self-Correcting Aspects of BDDCS Assignments, BDDCS Assignment Corrections, and Classification for more than 175 Additional Drugs. The Aaps Journal. PMID 26589308 DOI: 10.1208/S12248-015-9845-2  0.421
2015 Zheng Y, Chen X, Benet LZ. Reliability of In Vitro and In Vivo Methods for Predicting the Effect of P-Glycoprotein on the Delivery of Antidepressants to the Brain. Clinical Pharmacokinetics. PMID 26293617 DOI: 10.1007/S40262-015-0310-2  0.352
2015 Garrison KL, Sahin S, Benet LZ. Few Drugs Display Flip-Flop Pharmacokinetics and These Are Primarily Associated with Classes 3 and 4 of the BDDCS. Journal of Pharmaceutical Sciences. 104: 3229-35. PMID 26010239 DOI: 10.1002/Jps.24505  0.443
2015 Hosey CM, Benet LZ. Predicting the extent of metabolism using in vitro permeability rate measurements and in silico permeability rate predictions. Molecular Pharmaceutics. 12: 1456-66. PMID 25816851 DOI: 10.1021/Mp500783G  0.39
2015 Zheng Y, Benet LZ, Okochi H, Chen X. pH Dependent but not P-gp Dependent Bidirectional Transport Study of S-propranolol: The Importance of Passive Diffusion. Pharmaceutical Research. 32: 2516-26. PMID 25690341 DOI: 10.1007/S11095-015-1640-3  0.35
2015 Parasrampuria DA, Benet LZ. Inclusion of placebos and blinding for ascending dose first-in-human studies and other underpowered phase 1 studies has not been justified and on balance is not useful. Basic & Clinical Pharmacology & Toxicology. 117: 44-51. PMID 25406995 DOI: 10.1111/Bcpt.12352  0.337
2015 Estudante M, Sampayo C, Carvalho C, Morais J, Benet L. Correlation of rat intestinal permeability rate measures with human absorption and metabolism to improve BCS and BDDCS predictions Toxicology Letters. 238: S379. DOI: 10.1016/J.Toxlet.2015.08.1082  0.312
2014 Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. The Aaps Journal. 16: 1358-65. PMID 25274610 DOI: 10.1208/S12248-014-9673-9  0.424
2014 Hosey CM, Broccatelli F, Benet LZ. Predicting when biliary excretion of parent drug is a major route of elimination in humans. The Aaps Journal. 16: 1085-96. PMID 25004821 DOI: 10.1208/S12248-014-9636-1  0.453
2014 Larregieu CA, Benet LZ. Distinguishing between the permeability relationships with absorption and metabolism to improve BCS and BDDCS predictions in early drug discovery. Molecular Pharmaceutics. 11: 1335-44. PMID 24628254 DOI: 10.1021/Mp4007858  0.811
2013 Estudante M, Maya M, Morais JG, Soveral G, Benet LZ. Effect of P-glycoprotein on the rat intestinal permeability and metabolism of the BDDCS class 1 drug verapamil. Molecular Pharmaceutics. 10: 4038-45. PMID 24044638 DOI: 10.1021/Mp400381P  0.45
2013 Smelick GS, Heffron TP, Chu L, Dean B, West DA, Duvall SL, Lum BL, Budha N, Holden SN, Benet LZ, Frymoyer A, Dresser MJ, Ware JA. Prevalence of acid-reducing agents (ARA) in cancer populations and ARA drug-drug interaction potential for molecular targeted agents in clinical development. Molecular Pharmaceutics. 10: 4055-62. PMID 24044612 DOI: 10.1021/Mp400403S  0.307
2013 Frassetto L, Floren L, Barin B, Browne M, Wolfe A, Roland M, Stock P, Carlson L, Christians U, Benet L. Changes in clearance, volume and bioavailability of immunosuppressants when given with HAART in HIV-1 infected liver and kidney transplant recipients. Biopharmaceutics & Drug Disposition. 34: 442-51. PMID 24030928 DOI: 10.1002/Bdd.1860  0.404
2013 Horng H, Benet LZ. The nonenzymatic reactivity of the acyl-linked metabolites of mefenamic acid toward amino and thiol functional group bionucleophiles. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 1923-33. PMID 23975029 DOI: 10.1124/Dmd.113.053223  0.712
2013 Silber BM, Rao S, Fife KL, Gallardo-Godoy A, Renslo AR, Dalvie DK, Giles K, Freyman Y, Elepano M, Gever JR, Li Z, Jacobson MP, Huang Y, Benet LZ, Prusiner SB. Pharmacokinetics and metabolism of 2-aminothiazoles with antiprion activity in mice. Pharmaceutical Research. 30: 932-50. PMID 23417511 DOI: 10.1007/S11095-012-0912-4  0.351
2013 Horng H, Benet LZ. Characterization of the acyl-adenylate linked metabolite of mefenamic Acid. Chemical Research in Toxicology. 26: 465-76. PMID 23402341 DOI: 10.1021/Tx300520J  0.735
2013 Larregieu CA, Benet LZ. Drug discovery and regulatory considerations for improving in silico and in vitro predictions that use Caco-2 as a surrogate for human intestinal permeability measurements. The Aaps Journal. 15: 483-97. PMID 23344793 DOI: 10.1208/S12248-013-9456-8  0.795
2013 Budha NR, Benet LZ, Ware JA. Response to "drug interactions produced by proton pump inhibitors: Not simply a ph effect" Clinical Pharmacology and Therapeutics. 93: 151. PMID 23169432 DOI: 10.1038/Clpt.2012.206  0.325
2013 Benet LZ. The role of BCS (biopharmaceutics classification system) and BDDCS (biopharmaceutics drug disposition classification system) in drug development. Journal of Pharmaceutical Sciences. 102: 34-42. PMID 23147500 DOI: 10.1002/Jps.23359  0.38
2013 Estudante M, Morais JG, Soveral G, Benet LZ. Intestinal drug transporters: an overview. Advanced Drug Delivery Reviews. 65: 1340-56. PMID 23041352 DOI: 10.1016/J.Addr.2012.09.042  0.431
2012 Benet LZ. A step closer to personalized chemotherapy: Consideration of the influence of genetic variation in hepatic uptake transporters on the metabolism of CYP3A substrates Clinical Pharmacology and Therapeutics. 92: 551-552. PMID 23085879 DOI: 10.1038/Clpt.2012.165  0.416
2012 Budha NR, Frymoyer A, Smelick GS, Jin JY, Yago MR, Dresser MJ, Holden SN, Benet LZ, Ware JA. Drug absorption interactions between oral targeted anticancer agents and PPIs: Is pH-dependent solubility the achilles heel of targeted therapy Clinical Pharmacology and Therapeutics. 92: 203-213. PMID 22739140 DOI: 10.1038/Clpt.2012.73  0.308
2012 Liu W, Okochi H, Benet LZ, Zhai SD. Sotalol permeability in cultured-cell, rat intestine, and PAMPA system. Pharmaceutical Research. 29: 1768-74. PMID 22350803 DOI: 10.1007/S11095-012-0699-3  0.348
2012 Benet LZ. Benet L Z and Galeazzi R L: noncompartmental determination of the steady-state volume of distribution, J Pharm Sci 68, 1071-1074, 1979--the backstory. The Aaps Journal. 14: 164-7. PMID 22302585 DOI: 10.1208/S12248-012-9326-9  0.318
2012 Broccatelli F, Larregieu CA, Cruciani G, Oprea TI, Benet LZ. Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Advanced Drug Delivery Reviews. 64: 95-109. PMID 22261306 DOI: 10.1016/J.Addr.2011.12.008  0.804
2012 Broccatelli F, Cruciani G, Benet LZ, Oprea TI. BDDCS class prediction for new molecular entities. Molecular Pharmaceutics. 9: 570-80. PMID 22224483 DOI: 10.1021/Mp2004302  0.412
2011 Grover A, Frassetto LA, Benet LZ, Chakkera HA. Pharmacokinetic differences corroborate observed low tacrolimus dosage in Native American renal transplant patients. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 2017-9. PMID 21849516 DOI: 10.1124/Dmd.111.041350  0.576
2011 Benet LZ, Broccatelli F, Oprea TI. BDDCS applied to over 900 drugs. The Aaps Journal. 13: 519-47. PMID 21818695 DOI: 10.1208/S12248-011-9290-9  0.433
2011 Reyes M, Benet LZ. Effects of uremic toxins on transport and metabolism of different biopharmaceutics drug disposition classification system xenobiotics. Journal of Pharmaceutical Sciences. 100: 3831-42. PMID 21618544 DOI: 10.1002/Jps.22640  0.686
2011 Park MS, Okochi H, Benet LZ. Is Ciprofloxacin a Substrate of P-glycoprotein? Archives of Drug Information. 4: 1-9. PMID 21572514 DOI: 10.1111/J.1753-5174.2010.00032.X  0.31
2011 Grover A, Benet LZ. Intermittent drug dosing intervals guided by the operational multiple dosing half lives for predictable plasma accumulation and fluctuation. Journal of Pharmacokinetics and Pharmacodynamics. 38: 369-83. PMID 21499748 DOI: 10.1007/S10928-011-9198-0  0.611
2011 Chen ML, Amidon GL, Benet LZ, Lennernas H, Yu LX. The BCS, BDDCS, and regulatory guidances. Pharmaceutical Research. 28: 1774-8. PMID 21491148 DOI: 10.1007/S11095-011-0438-1  0.447
2011 Gottschalk S, Cummins CL, Leibfritz D, Christians U, Benet LZ, Serkova NJ. Age and sex differences in the effects of the immunosuppressants cyclosporine, sirolimus and everolimus on rat brain metabolism. Neurotoxicology. 32: 50-7. PMID 21075140 DOI: 10.1016/J.Neuro.2010.10.006  0.607
2011 Benet LZ. Transporter-Enzyme Interplay and Its Importance in Defining Drug Absorption and Disposition Annual Review of Pharmacology and Toxicology. 52: 110301101444027. DOI: 10.1146/Annurev-Pharmtox-010611-134726  0.397
2010 Benet LZ. Clearance (née Rowland) concepts: a downdate and an update. Journal of Pharmacokinetics and Pharmacodynamics. 37: 529-39. PMID 21113650 DOI: 10.1007/S10928-010-9187-8  0.443
2010 Aarons L, Benet LZ. Founding figures of pharmacokinetics: tribute to Malcolm Rowland. Journal of Pharmacokinetics and Pharmacodynamics. 37: 525-7. PMID 21069561 DOI: 10.1007/S10928-010-9178-9  0.36
2010 Frymoyer A, Shugarts S, Browne M, Wu AHB, Frassetto L, Benet LZ. Effect of single-dose rifampin on the pharmacokinetics of warfarin in healthy volunteers Clinical Pharmacology and Therapeutics. 88: 540-547. PMID 20703222 DOI: 10.1038/Clpt.2010.142  0.378
2010 Benet LZ, Larregieu CA. The FDA should eliminate the ambiguities in the current BCS biowaiver guidance and make public the drugs for which BCS biowaivers have been granted. Clinical Pharmacology and Therapeutics. 88: 405-7. PMID 20668447 DOI: 10.1038/Clpt.2010.149  0.8
2010 Giacomini KM, Huang SM, Tweedie DJ, Benet LZ, Brouwer KL, Chu X, Dahlin A, Evers R, Fischer V, Hillgren KM, Hoffmaster KA, Ishikawa T, Keppler D, Kim RB, et al. Membrane transporters in drug development. Nature Reviews. Drug Discovery. 9: 215-36. PMID 20190787 DOI: 10.1038/Nrd3028  0.417
2010 Sun H, Frassetto LA, Huang Y, Benet LZ. Hepatic clearance, but not gut availability, of erythromycin is altered in patients with end-stage renal disease Clinical Pharmacology and Therapeutics. 87: 465-472. PMID 20090676 DOI: 10.1038/Clpt.2009.247  0.344
2010 Benet LZ. Predicting drug disposition via application of a Biopharmaceutics Drug Disposition Classification System. Basic & Clinical Pharmacology & Toxicology. 106: 162-7. PMID 20002064 DOI: 10.1111/J.1742-7843.2009.00498.X  0.46
2010 Grillo MP, Wait JC, Tadano Lohr M, Khera S, Benet LZ. Stereoselective flunoxaprofen-S-acyl-glutathione thioester formation mediated by acyl-CoA formation in rat hepatocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 38: 133-42. PMID 19786506 DOI: 10.1124/Dmd.109.029371  0.314
2010 Grover A, Benet LZ. Transporter-based drug-drug interactions and their effect on distribution volumes Enzyme- and Transporter-Based Drug-Drug Interactions: Progress and Future Challenges. 437-471. DOI: 10.1007/978-1-4419-0840-7_18  0.586
2009 Benet LZ. The drug transporter-metabolism alliance: uncovering and defining the interplay. Molecular Pharmaceutics. 6: 1631-43. PMID 19874004 DOI: 10.1021/Mp900253N  0.421
2009 Benet LZ. A holy grail of clinical pharmacology: Prediction of drug pharmacokinetics and pharmacodynamics in the individual patient Clinical Pharmacology and Therapeutics. 86: 133-134. PMID 19621007 DOI: 10.1038/Clpt.2009.102  0.422
2009 Shugarts S, Benet LZ. The role of transporters in the pharmacokinetics of orally administered drugs. Pharmaceutical Research. 26: 2039-54. PMID 19568696 DOI: 10.1007/S11095-009-9924-0  0.821
2009 de Souza J, Benet LZ, Huang Y, Storpirtis S. Comparison of bidirectional lamivudine and zidovudine transport using MDCK, MDCK-MDR1, and Caco-2 cell monolayers. Journal of Pharmaceutical Sciences. 98: 4413-9. PMID 19472342 DOI: 10.1002/Jps.21744  0.357
2009 Grover A, Benet LZ. Effects of drug transporters on volume of distribution. The Aaps Journal. 11: 250-61. PMID 19399628 DOI: 10.1208/S12248-009-9102-7  0.623
2009 Zheng HX, Huang Y, Frassetto LA, Benet LZ. Elucidating rifampin's inducing and inhibiting effects on glyburide pharmacokinetics and blood glucose in healthy volunteers: Unmasking the differential effects of enzyme induction and transporter inhibition for a drug and its primary metabolite Clinical Pharmacology and Therapeutics. 85: 78-85. PMID 18843263 DOI: 10.1038/Clpt.2008.186  0.416
2009 Gwaza L, Wolfe AR, Benet LZ, Guglielmo BJ, Chagwedera TE, Maponga CC, Masimirembwa CM. In vitro inhibitory effects of Hypoxis obtusa and Dicoma anomala on cyp450 enzymes and p-glycoprotein African Journal of Pharmacy and Pharmacology. 3: 539-546. DOI: 10.5897/Ajpp.9000184  0.396
2008 Monera TG, Wolfe AR, Maponga CC, Benet LZ, Guglielmo J. Moringa oleifera leaf extracts inhibit 6beta-hydroxylation of testosterone by CYP3A4. Journal of Infection in Developing Countries. 2: 379-83. PMID 19745507 DOI: 10.3855/Jidc.201  0.307
2008 Sahin S, Benet LZ. The operational multiple dosing half-life: a key to defining drug accumulation in patients and to designing extended release dosage forms. Pharmaceutical Research. 25: 2869-77. PMID 19015955 DOI: 10.1007/S11095-008-9787-9  0.303
2008 Grillo MP, Hua F, March KL, Benet LZ, Knutson CG, Ware JA. Gamma-glutamyltranspeptidase-mediated degradation of diclofenac-S-acyl-glutathione in vitro and in vivo in rat. Chemical Research in Toxicology. 21: 1933-8. PMID 18693772 DOI: 10.1021/Tx800073P  0.301
2008 Benet LZ, Amidon GL, Barends DM, Lennernäs H, Polli JE, Shah VP, Stavchansky SA, Yu LX. The use of BDDCS in classifying the permeability of marketed drugs. Pharmaceutical Research. 25: 483-8. PMID 18236138 DOI: 10.1007/S11095-007-9523-X  0.424
2008 Custodio JM, Wu CY, Benet LZ. Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption. Advanced Drug Delivery Reviews. 60: 717-33. PMID 18199522 DOI: 10.1016/J.Addr.2007.08.043  0.75
2008 Li C, Grillo MP, Badagnani I, Fife KL, Benet LZ. Differential effects of fibrates on the metabolic activation of 2-phenylpropionic acid in rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 682-7. PMID 18187563 DOI: 10.1124/Dmd.107.017764  0.56
2007 Frassetto LA, Browne M, Cheng A, Wolfe AR, Roland ME, Stock PG, Carlson L, Benet LZ. Immunosuppressant pharmacokinetics and dosing modifications in HIV-1 infected liver and kidney transplant recipients. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 7: 2816-20. PMID 17949460 DOI: 10.1111/J.1600-6143.2007.02007.X  0.336
2007 Frassetto LA, Poon S, Tsourounis C, Valera C, Benet LZ. Effects of uptake and efflux transporter inhibition on erythromycin breath test results Clinical Pharmacology and Therapeutics. 81: 828-832. PMID 17361125 DOI: 10.1038/Sj.Clpt.6100148  0.332
2007 Olsen J, Li C, Skonberg C, Bjørnsdottir I, Sidenius U, Benet LZ, Hansen SH. Studies on the metabolism of tolmetin to the chemically reactive acyl-coenzyme A thioester intermediate in rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 758-64. PMID 17303625 DOI: 10.1124/Dmd.106.013334  0.55
2007 Benet LZ. Review and critique of the institute of medicine report "The future of drug safety" Clinical Pharmacology and Therapeutics. 81: 158-161. PMID 17259941 DOI: 10.1038/Sj.Clpt.6100083  0.336
2007 Lau YY, Huang Y, Frassetto L, Benet LZ. effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers. Clinical Pharmacology and Therapeutics. 81: 194-204. PMID 17192770 DOI: 10.1038/Sj.Clpt.6100038  0.619
2006 Lam JL, Shugarts SB, Okochi H, Benet LZ. Elucidating the effect of final-day dosing of rifampin in induction studies on hepatic drug disposition and metabolism. The Journal of Pharmacology and Experimental Therapeutics. 319: 864-70. PMID 16905688 DOI: 10.1124/Jpet.106.108282  0.8
2006 Lam JL, Okochi H, Huang Y, Benet LZ. In vitro and in vivo correlation of hepatic transporter effects on erythromycin metabolism: characterizing the importance of transporter-enzyme interplay. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 1336-44. PMID 16698890 DOI: 10.1124/Dmd.106.009258  0.794
2006 Lau YY, Okochi H, Huang Y, Benet LZ. Pharmacokinetics of atorvastatin and its hydroxy metabolites in rats and the effects of concomitant rifampicin single doses: relevance of first-pass effect from hepatic uptake transporters, and intestinal and hepatic metabolism. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 1175-81. PMID 16624870 DOI: 10.1124/Dmd.105.009076  0.64
2006 Huang Y, Okochi H, May BC, Legname G, Prusiner SB, Benet LZ, Guglielmo BJ, Lin ET. Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 1136-44. PMID 16581945 DOI: 10.1124/Dmd.105.008664  0.381
2006 Lau YY, Okochi H, Huang Y, Benet LZ. Multiple transporters affect the disposition of atorvastatin and its two active hydroxy metabolites: application of in vitro and ex situ systems. The Journal of Pharmacology and Experimental Therapeutics. 316: 762-71. PMID 16258024 DOI: 10.1124/Jpet.105.093088  0.63
2006 Sun H, Frassetto L, Benet LZ. Effects of renal failure on drug transport and metabolism. Pharmacology & Therapeutics. 109: 1-11. PMID 16085315 DOI: 10.1016/J.Pharmthera.2005.05.010  0.396
2006 Lau YY, Okochi H, Huang Y, Benet LZ. Response to comments on "multiple transporters affect the disposition of atorvastatin and its two active hydroxy metabolites: Application of in vitro and ex situ systems" [2] Journal of Pharmacology and Experimental Therapeutics. 316: 1387. DOI: 10.1124/jpet.105.099473  0.495
2005 Olsen J, Li C, Bjørnsdottir I, Sidenius U, Hansen SH, Benet LZ. In vitro and in vivo studies on acyl-coenzyme A-dependent bioactivation of zomepirac in rats. Chemical Research in Toxicology. 18: 1729-36. PMID 16300382 DOI: 10.1021/Tx0501785  0.525
2005 Chang JH, Benet LZ. Glucuronidation and the transport of the glucuronide metabolites in LLC-PK1 cells. Molecular Pharmaceutics. 2: 428-34. PMID 16196496 DOI: 10.1021/Mp050018M  0.384
2005 Frassetto L, Baluom M, Jacobsen W, Christians U, Roland ME, Stock PG, Carlson L, Benet LZ. Cyclosporine pharmacokinetics and dosing modifications in human immunodeficiency virus-infected liver and kidney transplant recipients. Transplantation. 80: 13-7. PMID 16003227 DOI: 10.1097/01.Tp.0000165111.09687.4E  0.325
2005 Benet LZ. There are no useful CYP3A probes that quantitatively predict the in vivo kinetics of other CYP3A substrates and no expectation that one will be found. Molecular Interventions. 5: 79-83. PMID 15821156 DOI: 10.1124/Mi.5.2.5  0.418
2005 Putnam WS, Woo JM, Huang Y, Benet LZ. Effect of the MDR1 C3435T variant and P-glycoprotein induction on dicloxacillin pharmacokinetics. Journal of Clinical Pharmacology. 45: 411-21. PMID 15778422 DOI: 10.1177/0091270004273492  0.71
2005 Wu CY, Benet LZ. Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system. Pharmaceutical Research. 22: 11-23. PMID 15771225 DOI: 10.1007/S11095-004-9004-4  0.462
2005 SUN H, HUANG Y, OKOCHI H, FRASSETTO L, BENET L. Uremic toxins inhibit hepatic uptake of eprosartan Clinical Pharmacology & Therapeutics. 77: P2-P2. DOI: 10.1016/J.Clpt.2004.11.012  0.335
2004 Lam JL, Benet LZ. Hepatic microsome studies are insufficient to characterize in vivo hepatic metabolic clearance and metabolic drug-drug interactions: studies of digoxin metabolism in primary rat hepatocytes versus microsomes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 32: 1311-6. PMID 15483198 DOI: 10.1124/Dmd.32.11.1311  0.799
2004 Ikeno F, Lyons J, Kaneda H, Baluom M, Benet LZ, Rezaee M. Novel percutaneous adventitial drug delivery system for regional vascular treatment. Catheterization and Cardiovascular Interventions : Official Journal of the Society For Cardiac Angiography & Interventions. 63: 222-30. PMID 15390346 DOI: 10.1002/Ccd.20167  0.363
2004 Egge-Jacobsen W, Unger M, Niemann CU, Baluom M, Hirai S, Benet LZ, Christians U. Automated, fast, and sensitive quantification of drugs in human plasma by LC/LC-MS: quantification of 6 protease inhibitors and 3 nonnucleoside transcriptase inhibitors. Therapeutic Drug Monitoring. 26: 546-62. PMID 15385839 DOI: 10.1097/00007691-200410000-00014  0.366
2004 Christians U, Gottschalk S, Miljus J, Hainz C, Benet LZ, Leibfritz D, Serkova N. Alterations in glucose metabolism by cyclosporine in rat brain slices link to oxidative stress: interactions with mTOR inhibitors. British Journal of Pharmacology. 143: 388-96. PMID 15339861 DOI: 10.1038/Sj.Bjp.0705939  0.301
2004 Kim WY, Benet LZ. P-glycoprotein (P-gp/MDR1)-mediated efflux of sex-steroid hormones and modulation of P-gp expression in vitro. Pharmaceutical Research. 21: 1284-93. PMID 15290871 DOI: 10.1023/B:Pham.0000033017.52484.81  0.517
2004 Sun H, Huang Y, Frassetto L, Benet LZ. Effects of uremic toxins on hepatic uptake and metabolism of erythromycin. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 32: 1239-46. PMID 15286055 DOI: 10.1124/Dmd.104.000521  0.386
2004 Benet LZ, Cummins CL, Wu CY. Unmasking the dynamic interplay between efflux transporters and metabolic enzymes. International Journal of Pharmaceutics. 277: 3-9. PMID 15158963 DOI: 10.1016/J.Ijpharm.2002.12.002  0.654
2004 Serkova NJ, Christians U, Benet LZ. Biochemical mechanisms of cyclosporine neurotoxicity. Molecular Interventions. 4: 97-107. PMID 15087483 DOI: 10.1124/Mi.4.2.7  0.307
2004 Lau YY, Wu CY, Okochi H, Benet LZ. Ex situ inhibition of hepatic uptake and efflux significantly changes metabolism: hepatic enzyme-transporter interplay. The Journal of Pharmacology and Experimental Therapeutics. 308: 1040-5. PMID 14634033 DOI: 10.1124/Jpet.103.061770  0.606
2004 Cummins CL, Jacobsen W, Christians U, Benet LZ. CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolam. The Journal of Pharmacology and Experimental Therapeutics. 308: 143-55. PMID 14569063 DOI: 10.1124/Jpet.103.058065  0.673
2003 Frassetto L, Thai T, Aggarwal AM, Bucher P, Jacobsen W, Christians U, Benet LZ, Floren LC. Pharmacokinetic interactions between cyclosporine and protease inhibitors in HIV+ subjects. Drug Metabolism and Pharmacokinetics. 18: 114-20. PMID 15618725 DOI: 10.2133/Dmpk.18.114  0.358
2003 Wu CY, Benet LZ. Disposition of tacrolimus in isolated perfused rat liver: influence of troleandomycin, cyclosporine, and gg918. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 1292-5. PMID 14570757 DOI: 10.1124/Dmd.31.11.1292  0.377
2003 Benet LZ, Cummins CL, Wu CY. Transporter-enzyme interactions: implications for predicting drug-drug interactions from in vitro data. Current Drug Metabolism. 4: 393-8. PMID 14529371 DOI: 10.2174/1389200033489389  0.679
2003 Li C, Olurinde MO, Hodges LM, Grillo MP, Benet LZ. Covalent binding of 2-phenylpropionyl-S-acyl-CoA thioester to tissue proteins in vitro. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 727-30. PMID 12756204 DOI: 10.1124/Dmd.31.6.727  0.551
2003 Cummins CL, Salphati L, Reid MJ, Benet LZ. In vivo modulation of intestinal CYP3A metabolism by P-glycoprotein: studies using the rat single-pass intestinal perfusion model. The Journal of Pharmacology and Experimental Therapeutics. 305: 306-14. PMID 12649383 DOI: 10.1124/Jpet.102.044719  0.666
2003 Li C, Grillo MP, Benet LZ. In vivo mechanistic studies on the metabolic activation of 2-phenylpropionic acid in rat. The Journal of Pharmacology and Experimental Therapeutics. 305: 250-6. PMID 12649376 DOI: 10.1124/Jpet.102.043174  0.563
2003 Li C, Grillo MP, Benet LZ. In vitro studies on the chemical reactivity of 2,4-dichlorophenoxyacetyl-S-acyl-CoA thioester. Toxicology and Applied Pharmacology. 187: 101-9. PMID 12649042 DOI: 10.1016/S0041-008X(02)00043-1  0.5
2003 Putnam W, Desai D, Huang Y, Woo J, Benet L. The effect of induction conditions and MDR1 genotypes on dicloxacillin pharmacokinetics Clinical Pharmacology & Therapeutics. 73: P57-P57. DOI: 10.1016/S0009-9236(03)90568-6  0.672
2003 Benet LZ, Perotti BYT, Hardy L. Drug Absorption, Distribution, and Elimination Burger's Medicinal Chemistry and Drug Discovery. 633-647. DOI: 10.1002/0471266949.Bmc037  0.392
2002 Unger M, Holzgrabe U, Jacobsen W, Cummins C, Benet LZ. Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava). Planta Medica. 68: 1055-8. PMID 12494328 DOI: 10.1055/S-2002-36360  0.59
2002 Li C, Benet LZ, Grillo MP. Enantioselective covalent binding of 2-phenylpropionic Acid to protein in vitro in rat hepatocytes. Chemical Research in Toxicology. 15: 1480-7. PMID 12437340 DOI: 10.1021/Tx025600L  0.51
2002 Putnam WS, Ramanathan S, Pan L, Takahashi LH, Benet LZ. Functional characterization of monocarboxylic acid, large neutral amino acid, bile acid and peptide transporters, and P-glycoprotein in MDCK and Caco-2 cells. Journal of Pharmaceutical Sciences. 91: 2622-35. PMID 12434407 DOI: 10.1002/Jps.10264  0.702
2002 Cummins CL, Wu CY, Benet LZ. Sex-related differences in the clearance of cytochrome P450 3A4 substrates may be caused by P-glycoprotein. Clinical Pharmacology and Therapeutics. 72: 474-89. PMID 12426511 DOI: 10.1067/Mcp.2002.128388  0.583
2002 Li C, Benet LZ, Grillo MP. Studies on the chemical reactivity of 2-phenylpropionic acid 1-O-acyl glucuronide and S-acyl-CoA thioester metabolites. Chemical Research in Toxicology. 15: 1309-17. PMID 12387630 DOI: 10.1021/Tx020013L  0.52
2002 Christians U, Jacobsen W, Benet LZ, Lampen A. Mechanisms of clinically relevant drug interactions associated with tacrolimus. Clinical Pharmacokinetics. 41: 813-51. PMID 12190331 DOI: 10.2165/00003088-200241110-00003  0.424
2002 Susanto M, Benet LZ. Can the enhanced renal clearance of antibiotics in cystic fibrosis patients be explained by P-glycoprotein transport? Pharmaceutical Research. 19: 457-62. PMID 12033380 DOI: 10.1023/A:1015191511817  0.358
2002 Flanagan SD, Takahashi LH, Liu X, Benet LZ. Contributions of saturable active secretion, passive transcellular, and paracellular diffusion to the overall transport of furosemide across adenocarcinoma (Caco-2) cells. Journal of Pharmaceutical Sciences. 91: 1169-77. PMID 11948555 DOI: 10.1002/Jps.10099  0.32
2002 Serkova N, Donohoe P, Gottschalk S, Hainz C, Niemann CU, Bickler PE, Litt L, Benet LZ, Leibfritz D, Christians U. Comparison of the effects of cyclosporin a on the metabolism of perfused rat brain slices during normoxia and hypoxia. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 22: 342-52. PMID 11891440 DOI: 10.1097/00004647-200203000-00012  0.302
2002 Parasrampuria DA, Lantz MV, Birnbaum JL, Vincenti FG, Benet LZ. Effect of calcineurin inhibitor therapy on P-gp expression and function in lymphocytes of renal transplant patients: a preliminary evaluation. Journal of Clinical Pharmacology. 42: 304-11. PMID 11865967 DOI: 10.1177/00912700222011337  0.342
2002 Cummins CL, Jacobsen W, Benet LZ. Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4. The Journal of Pharmacology and Experimental Therapeutics. 300: 1036-45. PMID 11861813 DOI: 10.1124/Jpet.300.3.1036  0.654
2002 Putnam WS, Pan L, Tsutsui K, Takahashi L, Benet LZ. Comparison of bidirectional cephalexin transport across MDCK and caco-2 cell monolayers: interactions with peptide transporters. Pharmaceutical Research. 19: 27-33. PMID 11837697 DOI: 10.1023/A:1013647114152  0.691
2002 Flanagan SD, Cummins CL, Susanto M, Liu X, Takahashi LH, Benet LZ. Comparison of furosemide and vinblastine secretion from cell lines overexpressing multidrug resistance protein (P-glycoprotein) and multidrug resistance-associated proteins (MRP1 and MRP2). Pharmacology. 64: 126-34. PMID 11834888 DOI: 10.1159/000056161  0.609
2001 Qiu Y, Benet LZ, Burlingame AL. Identification of hepatic protein targets of the reactive metabolites of the non-hepatotoxic regioisomer of acetaminophen, 3'-hydroxyacetanilide, in the mouse in vivo using two-dimensional gel electrophoresis and mass spectrometry Advances in Experimental Medicine and Biology. 500: 663-673. PMID 11765013 DOI: 10.1007/978-1-4615-0667-6_99  0.304
2001 Tsunoda SM, Harris RZ, Christians U, Velez RL, Freeman RB, Benet LZ, Warshaw A. Red wine decreases cyclosporine bioavailability. Clinical Pharmacology and Therapeutics. 70: 462-7. PMID 11719733 DOI: 10.1067/Mcp.2001.119814  0.411
2001 Cummins CL, Mangravite LM, Benet LZ. Characterizing the expression of CYP3A4 and efflux transporters (P-gp, MRP1, and MRP2) in CYP3A4-transfected Caco-2 cells after induction with sodium butyrate and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate. Pharmaceutical Research. 18: 1102-9. PMID 11587480 DOI: 10.1023/A:1010914624111  0.624
2001 Benet LZ, Cummins CL. The drug efflux-metabolism alliance: biochemical aspects. Advanced Drug Delivery Reviews. 50: S3-11. PMID 11576692 DOI: 10.1016/S0169-409X(01)00178-8  0.685
2001 Serkova N, Jacobsen W, Niemann CU, Litt L, Benet LZ, Leibfritz D, Christians U. Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain British Journal of Pharmacology. 133: 875-885. PMID 11454661 DOI: 10.1038/Sj.Bjp.0704142  0.327
2001 Kuhn B, Jacobsen W, Christians U, Benet LZ, Kollman PA. Metabolism of sirolimus and its derivative everolimus by cytochrome P450 3A4: insights from docking, molecular dynamics, and quantum chemical calculations. Journal of Medicinal Chemistry. 44: 2027-34. PMID 11384247 DOI: 10.1021/Jm010079Y  0.316
2001 Parasrampuria DA, Lantz MV, Benet LZ. A human lymphocyte based Ex Vivo assay to study the effect of drugs on P-glycoprotein (P-gp) function Pharmaceutical Research. 18: 39-44. PMID 11336351 DOI: 10.1023/A:1011070509191  0.38
2001 Zhang Y, Benet LZ. The gut as a barrier to drug absorption: Combined role of cytochrome P450 3A and P-glycoprotein Clinical Pharmacokinetics. 40: 159-168. PMID 11327196 DOI: 10.2165/00003088-200140030-00002  0.43
2001 Wacher VJ, Salphati L, Benet LZ. Active secretion and enterocytic drug metabolism barriers to drug absorption Advanced Drug Delivery Reviews. 46: 89-102. PMID 11259835 DOI: 10.1016/S0169-409X(00)00126-5  0.461
2001 Mancinelli LM, Frassetto L, Floren LC, Dressler D, Carrier S, Bekersky I, Benet LZ, Christians U. The pharmacokinetics and metabolic disposition of tacrolimus: A comparison across ethnic groups Clinical Pharmacology and Therapeutics. 69: 24-31. PMID 11180035 DOI: 10.1067/Mcp.2001.113183  0.313
2000 Boni JP, Korthbradley JM, Richards LS, Chiang ST, Hicks DR, Benet LZ. Chiral bioequivalence: Effect of absorption rate on racemic etodolac Clinical Pharmacokinetics. 39: 459-469. PMID 11192477 DOI: 10.2165/00003088-200039060-00006  0.389
2000 Christians U, First MR, Benet LZ. Recommendations for bioequivalence testing of cyclosporine generics revisited Therapeutic Drug Monitoring. 22: 330-345. PMID 10850403 DOI: 10.1097/00007691-200006000-00017  0.303
2000 Soldner A, Benet LZ, Mutschler E, Christians U. Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and Caco-2 cell monolayers British Journal of Pharmacology. 129: 1235-1243. PMID 10725273 DOI: 10.1038/Sj.Bjp.0703150  0.319
1999 Benet LZ, Izumi T, Zhang Y, Silverman JA, Wacher VJ. Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery Journal of Controlled Release. 62: 25-31. PMID 10518631 DOI: 10.1016/S0168-3659(99)00034-6  0.451
1999 Benet LZ. Relevance of pharmacokinetics in narrow therapeutic index drugs Transplantation Proceedings. 31: 1642-1644. PMID 10331032 DOI: 10.1016/S0041-1345(99)00083-4  0.412
1999 Soldner A, Christians U, Susanto M, Wacher VJ, Silverman JA, Benet LZ. Grapefruit juice activates P-glycoprotein-mediated drug transport Pharmaceutical Research. 16: 478-485. PMID 10227700 DOI: 10.1023/A:1011902625609  0.401
1999 Hausen B, Boeke K, Berry GJ, Segarra I, Benet LZ, Christians U, Morris RE. Coadministration of neoral and the novel rapamycin analog, SDZ RAD, to rat lung allograft recipients: Potentiation of immunosuppressive efficacy and improvement of tolerability by staggered versus simultaneous treatment Transplantation. 67: 956-962. PMID 10221478 DOI: 10.1097/00007890-199904150-00005  0.379
1999 Salphati L, Benet LZ. Metabolism of digoxin and digoxigenin digitoxosides in rat liver microsomes: Involvement of cytochrome P4503A Xenobiotica. 29: 171-185. PMID 10199593 DOI: 10.1080/004982599238722  0.318
1999 Flanagan SD, Benet LZ. Net secretion of furosemide is subject to indomethacin inhibition, as observed in Caco-2 monolayers and excised rat jejunum Pharmaceutical Research. 16: 221-224. PMID 10100306 DOI: 10.1023/A:1018868123367  0.312
1999 Soldner A, Christians U, Susanto M, Wacher VJ, Silverman JA, Benet LZ. Grapefruit juice exerts stimulatory effects on P-glycoprotein Clinical Pharmacology and Therapeutics. 65: 205. DOI: 10.1016/S0009-9236(99)80351-8  0.375
1999 Floren LC, Christians U, Zimmerman JJ, Neefe L, Schorer R, Rushworth D, Harper D, Renz J, Benet LZ. Sirolimus oral bioavailability increases ten-fold with concomitant ketoconazole Clinical Pharmacology and Therapeutics. 65: 159. DOI: 10.1016/S0009-9236(99)80167-2  0.301
1998 Tsunoda SM, Harris RZ, Mroczkowski PJ, Benet LZ. Preliminary evaluation of progestins as inducers of cytochrome P450 3A4 activity in postmenopausal women. Journal of Clinical Pharmacology. 38: 1137-43. PMID 11301566 DOI: 10.1177/009127009803801208  0.313
1998 Wacher VJ, Silverman JA, Zhang Y, Benet LZ. Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics Journal of Pharmaceutical Sciences. 87: 1322-1330. PMID 9811484 DOI: 10.1021/Js980082D  0.41
1998 Benet LZ. Impact of intraindividual variability of drugs on therapeutic outcomes: Lessons from outside transplantation Transplantation Proceedings. 30: 1650-1651. PMID 9723227 DOI: 10.1016/S0041-1345(98)00376-5  0.312
1998 Salphati L, Benet LZ. Effects of ketoconazole on digoxin absorption and disposition in rat Pharmacology. 56: 308-313. PMID 9654217 DOI: 10.1159/000028214  0.323
1998 Qiu Y, Benet LZ, Burlingame AL. Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry Journal of Biological Chemistry. 273: 17940-17953. PMID 9651401 DOI: 10.1074/Jbc.273.28.17940  0.3
1998 Jang GR, Benet LZ. Antiprogestin-mediated inactivation of cytochrome P450 3A4 Pharmacology. 56: 150-157. PMID 9532615 DOI: 10.1159/000028193  0.383
1998 Mizuma T, Benet LZ, Lin ET. Preparative chromatography of furosemide 1-O-acyl-glucuronide from urine using micronized amberlite XAD-2 and its application to other 1-O-acyl-glucuronides Preparative Biochemistry and Biotechnology. 28: 37-47. PMID 9516641 DOI: 10.1080/10826069808010125  0.308
1997 Jang GR, Benet LZ. Antiprogestin pharmacodynamics, pharmacokinetics, and metabolism: Implications for their long-term use Journal of Pharmacokinetics and Biopharmaceutics. 25: 647-672. PMID 9697076 DOI: 10.1023/A:1025725716343  0.425
1997 Lown KS, Mayo RR, Leichtman AB, Hsiao HL, Turgeon DK, Schmiedlin-Ren P, Brown MB, Guo W, Rossi SJ, Benet LZ, Watkins PB. Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine Clinical Pharmacology and Therapeutics. 62: 248-260. PMID 9333100 DOI: 10.1016/S0009-9236(97)90027-8  0.375
1997 Floren LC, Bekersky I, Benet LZ, Mekki Q, Dressier D, Lee JW, Roberts JP, Hebert MF. Tacrolimus oral bioavailability doubles with coadministration of ketoconazole Clinical Pharmacology and Therapeutics. 62: 41-49. PMID 9246018 DOI: 10.1016/S0009-9236(97)90150-8  0.337
1996 Sambol NC, Chiang J, O'Conner M, Liu CY, Lin ET, Goodman AM, Benet LZ, Karam JH. Pharmacokinetics and pharmacodynamics of metformin in healthy subjects and patients with noninsulin-dependent diabetes mellitus. Journal of Clinical Pharmacology. 36: 1012-21. PMID 8973990 DOI: 10.1177/009127009603601105  0.301
1996 Shah VP, Yacobi A, Barr WH, Benet LZ, Breimer D, Dobrinska MR, Endrenyi L, Fairweather W, Gillespie W, Gonzalez MA, Hooper J, Jackson A, Lesko LJ, Midha KK, Noonan PK, et al. Evaluation of orally administered highly variable drugs and drug formulations Pharmaceutical Research. 13: 1590-1594. PMID 8956322 DOI: 10.1023/A:1016468018478  0.406
1996 Jang GR, Wrighton SA, Benet LZ. Identification of CYP3A4 as the principal enzyme catalyzing mifepristone (RU 486) oxidation in human liver microsomes. Biochemical Pharmacology. 52: 753-61. PMID 8765473 DOI: 10.1016/0006-2952(96)00357-7  0.341
1996 Jaeger W, Benet LZ, Bornheim LM. Inhibition of cyclosporine and tetrahydrocannabinol metabolism by cannabidiol in mouse and human microsomes. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 26: 275-84. PMID 8730919 DOI: 10.3109/00498259609046707  0.366
1996 Chang T, Benet LZ, Hebert MF. The effect of water-soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers. Clinical Pharmacology and Therapeutics. 59: 297-303. PMID 8653992 DOI: 10.1016/S0009-9236(96)80007-5  0.397
1996 d'Uscio CH, Aweeka FT, Prueksaritanont T, Tomlanovich SJ, Gupta SK, Lantz MV, Gambertoglio JG, Garovoy MR, Benet LZ. Immunopharmacodynamic studies of cyclosporine in patients awaiting renal transplantation. Journal of Clinical Pharmacology. 35: 967-73. PMID 8568014 DOI: 10.1002/J.1552-4604.1995.Tb04012.X  0.345
1996 Harris RZ, Benet LZ, Schwartz JB. Gender effects in pharmacokinetics and pharmacodynamics. Drugs. 50: 222-39. PMID 8521756 DOI: 10.2165/00003495-199550020-00003  0.409
1996 Benet LZ, Wu C, Hebert MF, Wacher VJ. Intestinal drug metabolism and antitransport processes: A potential paradigm shift in oral drug delivery Journal of Controlled Release. 39: 139-143. DOI: 10.1016/0168-3659(95)00147-6  0.45
1995 Gomez DY, Wacher VJ, Tomlanovich SJ, Hebert MF, Benet LZ. The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine. Clinical Pharmacology and Therapeutics. 58: 15-9. PMID 7628178 DOI: 10.1016/0009-9236(95)90067-5  0.358
1995 Wacher VJ, Wu CY, Benet LZ. Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy. Molecular Carcinogenesis. 13: 129-34. PMID 7619215 DOI: 10.1002/Mc.2940130302  0.325
1995 Wu CY, Benet LZ, Hebert MF, Gupta SK, Rowland M, Gomez DY, Wacher VJ. Differentiation of absorption and first-pass gut and hepatic metabolism in humans: studies with cyclosporine. Clinical Pharmacology and Therapeutics. 58: 492-7. PMID 7586942 DOI: 10.1016/0009-9236(95)90168-X  0.373
1995 Zia-Amirhosseini P, Harris RZ, Brodsky FM, Benet LZ. Hypersensitivity to nonsteroidal anti-inflammatory drugs Nature Medicine. 1: 2-4. PMID 7584944 DOI: 10.1038/Nm0195-2B  0.323
1995 Benet LZ, Zia-Amirhosseini P. Basic principles of pharmacokinetics. Toxicologic Pathology. 23: 115-23. PMID 7569664 DOI: 10.1177/019262339502300203  0.395
1995 Wacher VJ, Liu T, Roberts JP, Ascher NL, Benet LZ. Time course of cyclosporine and ist motabolites in blood, liver and spleen of naive Lewis rats: comparison with preliminary data obtained in transplanted animals. Biopharmaceutics & Drug Disposition. 16: 303-12. PMID 7548779 DOI: 10.1002/Bdd.2510160406  0.31
1995 Zia-Amirhosseini P, Ding A, Burlingame AL, McDonagh AF, Benet LZ. Synthesis and mass-spectrometric characterization of human serum albumins modified by covalent binding of two non-steroidal anti-inflammatory drugs: tolmetin and zomepirac. The Biochemical Journal. 431-5. PMID 7487878 DOI: 10.1042/Bj3110431  0.339
1995 Benet LZ, Goyan JE. Bioequivalence and Narrow Therapeutic Index Drugs Pharmacotherapy. 15: 433-440. DOI: 10.1002/J.1875-9114.1995.Tb04379.X  0.386
1994 Zia-Amirhosseini P, Ojingwa JC, Spahn-Langguth H, McDonagh AF, Benet LZ. Enhanced covalent binding of tolmetin to proteins in humans after multiple dosing. Clinical Pharmacology and Therapeutics. 55: 21-7. PMID 8299313 DOI: 10.1038/Clpt.1994.5  0.324
1994 Benet LZ, Zech K. Pharmacokinetics--a relevant factor for the choice of a drug? Alimentary Pharmacology & Therapeutics. 25-32. PMID 8180291 DOI: 10.1111/J.1365-2036.1994.Tb00225.X  0.443
1994 Peck CC, Barr WH, Benet LZ, Collins J, Desjardins RE, Furst DE, Harter JG, Levy G, Ludden T, Rodman JH. Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development. Journal of Clinical Pharmacology. 34: 111-9. PMID 8163710 DOI: 10.1002/J.1552-4604.1994.Tb03974.X  0.393
1994 Gumbleton M, Benet LZ. Simultaneous pharmacodynamic modeling of the non-steady-state effects of three oral doses of 1,3-glyceryl dinitrate upon blood pressure in healthy volunteers. Journal of Pharmacokinetics and Biopharmaceutics. 21: 515-32. PMID 8145129 DOI: 10.1007/Bf01059112  0.359
1994 Aweeka FT, Tomlanovich SJ, Prueksaritanont T, Gupta SK, Benet LZ. Pharmacokinetics of orally and intravenously administered cyclosporine in pre-kidney transplant patients. Journal of Clinical Pharmacology. 34: 60-7. PMID 8132853 DOI: 10.1002/J.1552-4604.1994.Tb03967.X  0.334
1994 Ojingwa JC, Spahn-Langguth H, Benet LZ. Reversible binding of tolmetin, zomepirac, and their glucuronide conjugates to human serum albumin and plasma. Journal of Pharmacokinetics and Biopharmaceutics. 22: 19-40. PMID 8027947 DOI: 10.1007/Bf02353408  0.31
1994 Han C, Jung P, Sanders SW, Lin ET, Benet LZ. Pharmacokinetics of nitroglycerin and its four metabolites during nitroglycerin transdermal administration. Biopharmaceutics & Drug Disposition. 15: 179-83. PMID 8011969 DOI: 10.1002/Bdd.2510150210  0.394
1994 Perotti BY, Prueksaritanont T, Benet LZ. HPLC assay for FK 506 and two metabolites in isolated rat hepatocytes and rat liver microsomes. Pharmaceutical Research. 11: 844-7. PMID 7524055 DOI: 10.1023/A:1018977707960  0.398
1993 Spahn-Langguth H, Benet LZ. Microsomal acyl glucuronidation: enzyme-kinetic studies with labile glucuronides. Pharmacology. 46: 268-73. PMID 8488171 DOI: 10.1159/000139054  0.316
1993 Ding A, Ojingwa JC, McDonagh AF, Burlingame AL, Benet LZ. Evidence for covalent binding of acyl glucuronides to serum albumin via an imine mechanism as revealed by tandem mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America. 90: 3797-801. PMID 8483897 DOI: 10.1073/Pnas.90.9.3797  0.301
1993 Benet LZ, Spahn-Langguth H, Iwakawa S, Volland C, Mizuma T, Mayer S, Mutschler E, Lin ET. Predictability of the covalent binding of acidic drugs in man. Life Sciences. 53: PL141-6. PMID 8350674 DOI: 10.1016/0024-3205(93)90279-C  0.404
1993 Mayer S, Mutschler E, Benet LZ, Sphahn-Langguth H. In vitro and in vivo irreversible plasma protein binding of beclobric acid enantiomers. Chirality. 5: 120-5. PMID 8338721 DOI: 10.1002/Chir.530050304  0.367
1993 Lee FW, Hu J, Metzler CH, Benet LZ. Nitroglycerin dinitrate metabolites do not affect the pharmacokinetics and pharmacodynamics of nitroglycerin in the dog: A preliminary report Journal of Pharmacokinetics and Biopharmaceutics. 21: 163-173. PMID 8229678 DOI: 10.1007/Bf01059768  0.341
1993 Benet LZ. Pharmacokinetics of sustained-release etodolac. Rheumatology International. 13: S3-5. PMID 8210922 DOI: 10.1007/Bf00290277  0.363
1993 Lee FW, Salmonson T, Benet LZ. Pharmacokinetics and pharmacodynamics of nitroglycerin and its dinitrate metabolites in conscious dogs: Intravenous infusion studies Journal of Pharmacokinetics and Biopharmaceutics. 21: 533-550. PMID 8145130 DOI: 10.1007/Bf01059113  0.318
1993 Haefeli WE, Gumbleton M, Benet LZ, Hoffman BB, Blaschke TF. Comparison of vasodilatory responses to nitroglycerin and its dinitrate metabolites in human veins. Clinical Pharmacology and Therapeutics. 52: 590-6. PMID 1458768 DOI: 10.1038/Clpt.1992.196  0.345
1992 Benet LZ. Safety and pharmacokinetics: colloidal bismuth subcitrate. Scandinavian Journal of Gastroenterology. Supplement. 185: 29-35. PMID 1957122 DOI: 10.3109/00365529109093217  0.359
1992 Volland C, Benet LZ. In vitro enantioselective glucuronidation of fenoprofen. Pharmacology. 43: 53-60. PMID 1775510 DOI: 10.1159/000138828  0.319
1992 Lau DT, Benet LZ. Effects of sulfobromophthalein and ethacrynic acid on glyceryl trinitrate relaxation. Biochemical Pharmacology. 43: 2247-54. PMID 1599510 DOI: 10.1016/0006-2952(92)90184-K  0.309
1992 Prueksaritanont T, Koike M, Hoener BA, Benet LZ. Transport and metabolism of cyclosporine in isolated rat hepatocytes. The effects of lipids. Biochemical Pharmacology. 43: 1997-2006. PMID 1596287 DOI: 10.1016/0006-2952(92)90643-W  0.355
1992 Peck CC, Barr WH, Benet LZ, Collins J, Desjardins RE, Furst DE, Harter JG, Levy G, Ludden T, Rodman JH. Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development. Clinical Pharmacology and Therapeutics. 51: 465-73. PMID 1563216 DOI: 10.1038/Clpt.1992.47  0.393
1992 Higo N, Hinz RS, Lau DT, Benet LZ, Guy RH. Cutaneous metabolism of nitroglycerin in vitro. I. Homogenized versus intact skin. Pharmaceutical Research. 9: 187-90. PMID 1553339 DOI: 10.1023/A:1018925004345  0.311
1992 Han C, Gumbleton M, Lau DT, Benet LZ. Improved gas chromatographic assay for the simultaneous determination of nitroglycerin and its mono- and dinitrate metabolites. Journal of Chromatography. 579: 237-45. PMID 1429971 DOI: 10.1016/0378-4347(92)80387-6  0.329
1992 Hebert MF, Roberts JP, Prueksaritanont T, Benet LZ. Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction. Clinical Pharmacology and Therapeutics. 52: 453-7. PMID 1424418 DOI: 10.1038/Clpt.1992.171  0.383
1992 Peck CC, Barr WH, Benet LZ, Collins J, Desjardins RE, Furst DE, Harter JG, Levy G, Ludden T, Rodman JH. Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development. Journal of Pharmaceutical Sciences. 81: 605-10. PMID 1355792 DOI: 10.1002/Jps.2600810630  0.381
1992 Peck CC, Barr WH, Benet LZ, Collins J, Desjardins RE, Furst DE, Harter JG, Levy G, Ludden T, H. Rodman J, Sanathanan L, Schentag JJ, Shah VP, Sheiner LB, Skelly JP, et al. Opportunities for integration of pharmacokinetics, pharmacodynamics and toxicokinetics in rational drug development International Journal of Pharmaceutics. 82: 9-19. DOI: 10.1016/0378-5173(92)90066-B  0.398
1991 Volland C, Sun H, Benet LZ. Stereoselective analysis of fenoprofen and its metabolites. Journal of Chromatography. 534: 127-38. PMID 2094699 DOI: 10.1016/S0378-4347(00)82155-6  0.339
1991 Hammarlund-Udenaes M, Benet LZ. Prednisone and prednisolone interconversion in the rabbit utilizing unbound concentrations. Biopharmaceutics & Drug Disposition. 12: 467-77. PMID 1932610 DOI: 10.1002/Bdd.2510120608  0.318
1991 Benet LZ. Rho Chi Lecture. Ideals and innovation: drugs, generics, the FDA, and the pharmacist. Dicp : the Annals of Pharmacotherapy. 25: 427-30. PMID 1926916 DOI: 10.1177/106002809102500419  0.375
1991 Williams RL, Thakker KM, John V, Lin ET, Liang-Gee W, Benet LZ. Nitroglycerin absorption from transdermal systems: formulation effects and metabolite concentrations. Pharmaceutical Research. 8: 744-9. PMID 1905809 DOI: 10.1023/A:1015802101272  0.406
1991 Lau DT, Gumbleton M, Labisch C, Benet LZ. Pharmacokinetic studies of the nitroglycerin metabolites, 1,2- and 1,3- glyceryl dinitrates, in the rat. Biopharmaceutics & Drug Disposition. 12: 215-22. PMID 1905575 DOI: 10.1002/Bdd.2510120306  0.356
1991 Gumbleton M, Benet LZ. Drug metabolism and laboratory anesthetic protocols in the rat: examination of antipyrine pharmacokinetics. Pharmaceutical Research. 8: 544-6. PMID 1871056 DOI: 10.1023/A:1015827917684  0.402
1991 Hale VG, Aizawa K, Sheiner LB, Benet LZ. Disposition of prednisone and prednisolone in the perfused rabbit liver: Modeling hepatic metabolic processes Journal of Pharmacokinetics and Biopharmaceutics. 19: 597-614. PMID 1783993 DOI: 10.1007/Bf01062965  0.389
1991 Snah VP, Flynn GL, Guy RH, Maibach HI, Schaefer H, Skelly JP, Wester RC, Yacobi A, Anderson BD, Andersen KE, Barry BW, Behl CR, Benet LZ, Bronaugh RL, Bucks DAW, et al. In vivo percutaneous penetration/absorption. Sponsored by the American Association of Pharmaceutical Scientist, U.S. Food and Drug Administration, American Academy of Dermatology, Skin Pharmacology Society and the U.S. Army Environmental Hygiene Agency May 1-3, 1989, Washington, DC International Journal of Pharmaceutics. 74: 1-8. DOI: 10.1016/0378-5173(91)90402-A  0.358
1990 Gupta SK, Manfro RC, Tomlanovich SJ, Gambertoglio JG, Garovoy MR, Benet LZ. Effect of food on the pharmacokinetics of cyclosporine in healthy subjects following oral and intravenous administration. Journal of Clinical Pharmacology. 30: 643-53. PMID 2391396 DOI: 10.1002/J.1552-4604.1990.Tb01868.X  0.321
1990 Williams RL, Lin ET, Liang-Gee W, Blume CD, Benet LZ. Absorption and disposition of a new low-dose combination formulation of hydrochlorothiazide and triamterene. Biopharmaceutics & Drug Disposition. 11: 233-43. PMID 2328310 DOI: 10.1002/Bdd.2510110308  0.335
1990 Gupta SK, Benet LZ. High-fat meals increase the clearance of cyclosporine. Pharmaceutical Research. 7: 46-8. PMID 2300535 DOI: 10.1023/A:1015831408425  0.368
1990 Nakashima E, Rigod JF, Lin ET, Benet LZ. Pharmacokinetics of nitroglycerin and its dinitrate metabolites over a thirtyfold range of oral doses. Clinical Pharmacology and Therapeutics. 47: 592-8. PMID 2111749 DOI: 10.1038/Clpt.1990.80  0.32
1990 Wang LH, Rudolph AM, Benet LZ. Comparative Study of Acetaminophen Disposition in Sheep at Three Developmental Stages: the Fetal, Neonatal and Adult Periods Developmental Pharmacology and Therapeutics. 14: 161-179. DOI: 10.1159/000480915  0.361
1990 Gloff CA, Benet LZ. Pharmacokinetics and protein therapeutics Advanced Drug Delivery Reviews. 4: 359-386. DOI: 10.1016/0169-409X(90)90027-P  0.333
1990 Skelly JP, Amidon GL, Barr WH, Benet LZ, Carter JE, Robinson JR, Shah VP, Yacobi A. In vitro and in vivo testing and correlation for oral controlled/ modified release dosage forms. report of the 2nd workshop held December 1988, Washington, DC. U.S.A. Journal of Controlled Release. 14: 95-106. DOI: 10.1016/0168-3659(90)90064-Z  0.368
1989 Gloff CA, Benet LZ. Differential effects of the degree of renal damage on p-aminohippuric acid and inulin clearances in rats. Journal of Pharmacokinetics and Biopharmaceutics. 17: 169-77. PMID 2795454 DOI: 10.1007/Bf01059026  0.305
1989 Spahn H, Spahn I, Benet LZ. Probenecid-induced changes in the clearance of carprofen enantiomers: a preliminary study. Clinical Pharmacology and Therapeutics. 45: 500-5. PMID 2721105 DOI: 10.1038/Clpt.1989.64  0.362
1989 Watari N, Benet LZ. Determination of mean input time, mean residence time, and steady-state volume of distribution with multiple drug inputs. Journal of Pharmacokinetics and Biopharmaceutics. 17: 593-9. PMID 2614687 DOI: 10.1007/Bf01071351  0.329
1989 Gupta S, Benet L. HPLC Measurement of Cyclosporine in Blood Plasma and Urine and Simultaneous Measurement of its Four Metabolites in Blood Journal of Liquid Chromatography & Related Technologies. 12: 1451-1462. DOI: 10.1080/01483918908049516  0.304
1988 Schwartz JB, Upton RA, Lin ET, Williams RL, Benet LZ. Effect of cimetidine or ranitidine administration on nifedipine pharmacokinetics and pharmacodynamics. Clinical Pharmacology and Therapeutics. 43: 673-80. PMID 3378388 DOI: 10.1038/Clpt.1988.94  0.325
1988 Gawienowski M, Benet LZ, Fleckenstein L, Lin ET. Ion-paired liquid chromatographic method for the analysis of blood and plasma for the antimalarial drug halofantrine and its putative mono-debutylated metabolite. Journal of Chromatography. 430: 412-9. PMID 3235515 DOI: 10.1016/S0378-4347(00)83179-5  0.345
1988 Gloff CA, Mamelok RD, Benet LZ. Organic anion transport by basal-lateral membranes: effect of PAH and furosemide on each other's transport. Pharmacology. 37: 268-76. PMID 3194444 DOI: 10.1159/000138476  0.302
1988 Yu DK, Williams RL, Benet LZ, Lin ET, Giesing DH. Pharmacokinetics of nitroglycerin and metabolites in humans following oral dosing. Biopharmaceutics & Drug Disposition. 9: 557-65. PMID 3147725 DOI: 10.1002/Bod.2510090606  0.351
1988 Lee FW, Watari N, Rigod J, Benet LZ. Simultaneous determination of nitroglycerin and its dinitrate metabolites by capillary gas chromatography with electron-capture detection. Journal of Chromatography. 426: 259-66. PMID 3134385 DOI: 10.1016/S0378-4347(00)81954-4  0.302
1988 Nakashima E, Noonan PK, Benet LZ. Transdermal bioavailability and first-pass skin metabolism: a preliminary evaluation with nitroglycerin. Journal of Pharmacokinetics and Biopharmaceutics. 15: 423-37. PMID 3119815 DOI: 10.1007/Bf01066522  0.347
1987 Williams RL, Mordenti J, Upton RA, Lin ET, Gee WL, Blume CD, Benet LZ. Effects of formulation and food on the absorption of hydrochlorothiazide and triamterene or amiloride from combination diuretic products. Pharmaceutical Research. 4: 348-52. PMID 3508542 DOI: 10.1023/A:1016409606936  0.308
1987 Noonan PK, Benet LZ. Variable glyceryl dinitrate formation as a function of route of nitroglycerin administration. Clinical Pharmacology and Therapeutics. 42: 273-7. PMID 3113806 DOI: 10.1038/Clpt.1987.146  0.358
1987 Ferraiolo BL, Halldin MM, Asscher Y, Akita Y, Melmon KL, Benet LZ, Castagnoli N. Pharmacokinetics and excretion of unique beta-adrenergic agonists. Pharmacology. 34: 157-66. PMID 2884679 DOI: 10.1159/000138265  0.347
1987 Yturralde O, Lee R, Benet LZ, Fleckenstein L, Lin ETL. Ion-Paired Liquid Chromatographic Method for the Analysis of Pyridostigmine in Plasma Journal of Liquid Chromatography. 10: 2231-2246. DOI: 10.1080/01483918708068907  0.331
1986 Sörgel F, Ettinger B, Benet LZ. Metabolic fate and solubility of triamterene--not an explanation for triamterene nephrolithiasis. Journal of Pharmaceutical Sciences. 75: 129-32. PMID 3958920 DOI: 10.1002/Jps.2600750205  0.359
1986 Legler UF, Benet LZ. Marked alterations in dose-dependent prednisolone kinetics in women taking oral contraceptives. Clinical Pharmacology and Therapeutics. 39: 425-9. PMID 3956058 DOI: 10.1038/Clpt.1986.66  0.348
1986 Smith PC, McDonagh AF, Benet LZ. Irreversible binding of zomepirac to plasma protein in vitro and in vivo. The Journal of Clinical Investigation. 77: 934-9. PMID 3949982 DOI: 10.1172/Jci112392  0.38
1986 Williams RL, Thornhill MD, Upton RA, Blume C, Clark TS, Lin E, Benet LZ. Absorption and disposition of two combination formulations of hydrochlorothiazide and triamterene: influence of age and renal function. Clinical Pharmacology and Therapeutics. 40: 226-32. PMID 3731685 DOI: 10.1038/Clpt.1986.167  0.313
1986 Varughese A, Brater DC, Benet LZ, Lee CS. Ethambutol kinetics in patients with impaired renal function. The American Review of Respiratory Disease. 134: 34-8. PMID 3729159 DOI: 10.1164/Arrd.1986.134.1.34  0.302
1986 Shi RJ, Benet LZ, Lin ET. High-performance liquid chromatographic assay of basic amine drugs in plasma and urine using a silica gel column and an aqueous mobile phase. I. Amiloride. Journal of Chromatography. 377: 399-404. PMID 3711234 DOI: 10.1016/S0378-4347(00)80800-2  0.336
1986 Noonan PK, Benet LZ. The bioavailability of oral nitroglycerin. Journal of Pharmaceutical Sciences. 75: 241-3. PMID 3084757 DOI: 10.1002/Jps.2600750306  0.36
1985 Sörgel F, Ettinger B, Benet LZ. The true composition of kidney stones passed during triamterene therapy. The Journal of Urology. 134: 871-3. PMID 4057369 DOI: 10.1016/S0022-5347(17)47497-0  0.309
1985 Noonan PK, Williams RL, Benet LZ. Dose dependent pharmacokinetics of nitroglycerin after multiple intravenous infusions in healthy volunteers. Journal of Pharmacokinetics and Biopharmaceutics. 13: 143-57. PMID 3932639 DOI: 10.1007/Bf01059395  0.358
1985 Sheiner LB, Benet LZ. Premarketing observational studies of population pharmacokinetics of new drugs Clinical Pharmacology and Therapeutics. 38: 481-487. PMID 3931953 DOI: 10.1038/Clpt.1985.212  0.363
1985 Noonan PK, Benet LZ. Incomplete and delayed bioavailability of sublingual nitroglycerin. The American Journal of Cardiology. 55: 184-7. PMID 3917598 DOI: 10.1016/0002-9149(85)90325-X  0.386
1985 Smith PC, Langendijk PN, Bosso JA, Benet LZ. Effect of probenecid on the formation and elimination of acyl glucuronides: studies with zomepirac. Clinical Pharmacology and Therapeutics. 38: 121-7. PMID 3874742 DOI: 10.1038/Clpt.1985.146  0.404
1985 Benet LZ. Pharmacokinetics and metabolism of bepridil. The American Journal of Cardiology. 55: 8C-13C. PMID 3872057 DOI: 10.1016/0002-9149(85)90799-4  0.438
1984 Chiang CW, Benet LZ. Dose-dependent kinetics of probenecid in rhesus monkeys--infusion studies. Pharmacology. 28: 181-7. PMID 6728896 DOI: 10.1159/000137960  0.377
1984 Meister W, Benowitz NL, Benet LZ. Unchanged absorption of digoxin tablets in patients with cardiac failure. Pharmacology. 28: 90-4. PMID 6709691 DOI: 10.1159/000137948  0.327
1984 Langendijk PN, Smith PC, Hasegawa J, Benet LZ. Simultaneous determination of zomepirac and its major metabolite zomepirac glucuronide in human plasma and urine. Journal of Chromatography. 307: 371-9. PMID 6610684 DOI: 10.1016/S0378-4347(00)84108-0  0.307
1984 Upton RA, Williams RL, Lin ET, Gee WL, Blume CD, Benet LZ. Absence of a significant pharmacokinetic interaction between hydrochlorothiazide and triamterene when coadministered. Journal of Pharmacokinetics and Biopharmaceutics. 12: 575-86. PMID 6533293 DOI: 10.1007/Bf01059553  0.423
1984 Blume CD, Williams RL, Upton RA, Lin ET, Benet LZ. Bioequivalence study of a new tablet formulation of triamterene and hydrochlorothiazide. The American Journal of Medicine. 77: 59-61. PMID 6496560 DOI: 10.1016/S0002-9343(84)80009-1  0.368
1984 Noonan PK, Kanfer I, Riegelman S, Benet LZ. Determination of picogram nitroglycerin plasma concentrations using capillary gas chromatography with on-column injection. Journal of Pharmaceutical Sciences. 73: 923-7. PMID 6432997 DOI: 10.1002/Jps.2600730715  0.309
1983 O'Neill PJ, Yorgey KA, Renzi NL, Williams RL, Benet LZ. Disposition of zomepirac sodium in man. Journal of Clinical Pharmacology. 22: 470-6. PMID 7174855 DOI: 10.1002/J.1552-4604.1982.Tb02637.X  0.357
1983 Park GB, Kershner RP, Angellotti J, Williams RL, Benet LZ, Edelson J. Oral bioavailability and intravenous pharmacokinetics of amrinone in humans. Journal of Pharmaceutical Sciences. 72: 817-9. PMID 6886991 DOI: 10.1002/Jps.2600720726  0.324
1983 Smith DE, Benet LZ. Plasma protein binding of furosemide in kidney transplant patients. Journal of Pharmacokinetics and Biopharmaceutics. 10: 663-74. PMID 6763626 DOI: 10.1007/Bf01062547  0.305
1983 Smith DE, Benet LZ. Biotransformation of furosemide in kidney transplant patients. European Journal of Clinical Pharmacology. 24: 787-90. PMID 6350024 DOI: 10.1007/Bf00607088  0.35
1983 Baughman RA, Sorgel F, Mico BA, Benet LZ. Dose-dependent bioavailability of prazosin in beagle dogs Journal of Cardiovascular Pharmacology. 5: 613-617. PMID 6193359 DOI: 10.1097/00005344-198307000-00016  0.337
1982 Gustafson JH, Benet LZ. Saturable kinetics of intravenous chlorothiazide in the rhesus monkey. Journal of Pharmacokinetics and Biopharmaceutics. 9: 461-76. PMID 7310644 DOI: 10.1007/Bf01060889  0.346
1982 Hasegawa J, Lin ET, Williams RL, Sörgel F, Benet LZ. Pharmacokinetics of triamterene and its metabolite in man. Journal of Pharmacokinetics and Biopharmaceutics. 10: 507-23. PMID 7166735 DOI: 10.1007/Bf01059034  0.365
1982 Legler UF, Frey FJ, Benet LZ. Prednisolone clearance at steady state in man. The Journal of Clinical Endocrinology and Metabolism. 55: 762-7. PMID 7107818 DOI: 10.1210/Jcem-55-4-762  0.326
1982 Williams RL, Blume CD, Lin ET, Holford NH, Benet LZ. Relative bioavailability of chlorthalidone in humans: adverse influence of polyethylene glycol. Journal of Pharmaceutical Sciences. 71: 533-5. PMID 7097499 DOI: 10.1002/Jps.2600710514  0.302
1982 Williams RL, Davies RO, Berman RS, Holmes GI, Huber P, Gee WL, Lin ET, Benet LZ. Hydrochlorothiazide pharmacokinetics and pharmacologic effect: the influence of indomethacin. Journal of Clinical Pharmacology. 22: 32-41. PMID 7061724 DOI: 10.1002/J.1552-4604.1982.Tb05705.X  0.394
1982 Benet LZ, Frey FJ, Amend WJC, Lozada F. Endogenous and exogenous glucocorticoids in cushingoid patients Drug Intelligence and Clinical Pharmacy. 16: 863-868. PMID 6756849 DOI: 10.1177/106002808201601109  0.313
1982 Frey FJ, Gambertoglio JG, Frey BM, Benet LZ, Amend WJ. Nonlinear plasma protein binding and haemodialysis clearance of prednisolone. European Journal of Clinical Pharmacology. 23: 65-74. PMID 6751835 DOI: 10.1007/Bf01061379  0.334
1982 Frey BM, Frey FJ, Holford NHG, Lozada F, Benet LZ. Prednisolone pharmacodynamics assessed by inhibition of the mixed lymphocyte reaction Transplantation. 33: 578-584. PMID 6213074 DOI: 10.1097/00007890-198206000-00002  0.333
1981 Lee CS, Brater DC, Gambertoglio JG, Benet LZ. Disposition kinetics of ethambutol in man. Journal of Pharmacokinetics and Biopharmaceutics. 8: 335-46. PMID 7431225 DOI: 10.1007/Bf01059382  0.304
1981 Chiang CW, Benet LZ. Dose-dependent kinetics of probenecid in rhesus monkeys - intravenous bolus studies Pharmacology. 23: 326-336. PMID 7312942 DOI: 10.1159/000137568  0.34
1981 Williams RL, Furst DE, Mandel HG, Nicoll D, Konikoff JJ, Benet LZ. Effects of indomethacin and carprofen on renal homeostasis in rheumatoid arthritis patients and in healthy individuals. Journal of Clinical Pharmacology. 21: 493-500. PMID 7037867 DOI: 10.1002/J.1552-4604.1981.Tb05656.X  0.37
1981 Frey FJ, Amend WJC, Lozada F, Frey BM, Holford NHG, Benet LZ. Pharmacokinetics of prednisolone and endogenous hydrocortisone levels in cushingoid and non-cushingoid patients European Journal of Clinical Pharmacology. 21: 235-242. PMID 7032949 DOI: 10.1007/Bf00627926  0.331
1981 Frey FJ, Amend WJC, Lozada F, Benet LZ. Endogenous hydrocortisone, a possible factor contributing to the genesis of cushingoid habitus in patients on prednisone Journal of Clinical Endocrinology and Metabolism. 53: 1076-1080. PMID 7026594 DOI: 10.1210/Jcem-53-5-1076  0.309
1981 Smith DE, Gambertoglio JG, Vincenti F, Benet LZ. Furosemide kinetics and dynamics after kidney transplant. Clinical Pharmacology and Therapeutics. 30: 105-13. PMID 7016396 DOI: 10.1038/Clpt.1981.134  0.323
1981 Sheiner LB, Benet LZ, Pagliaro LA. A standard approach to compiling clinical pharmacokinetic data Journal of Pharmacokinetics and Biopharmaceutics. 9: 59-127. PMID 7014827 DOI: 10.1007/Bf01059343  0.335
1980 Baughman RA, Arnold S, Benet LZ, Lin ET, Chatterjee K, Williams RL. Altered prazosin pharmacokinetics in congestive heart failure. European Journal of Clinical Pharmacology. 17: 425-8. PMID 7398734 DOI: 10.1007/Bf00570159  0.339
1980 Smith DE, Gee WL, Brater DC, Lin ET, Benet LZ. Preliminary evaluation of furosemide-probenecid interaction in humans. Journal of Pharmaceutical Sciences. 69: 571-5. PMID 7381747 DOI: 10.1002/Jps.2600690526  0.347
1980 Lee CS, Marbury TC, Benet LZ. Clearance calculations in hemodialysis: application to blood, plasma, and dialysate measurements for ethambutol. Journal of Pharmacokinetics and Biopharmaceutics. 8: 69-81. PMID 7381692 DOI: 10.1007/Bf01059449  0.361
1980 Williams RL, Benet LZ. Drug pharmacokinetics in cardiac and hepatic disease Annual Review of Pharmacology and Toxicology. 20: 389-413. PMID 6992701 DOI: 10.1146/Annurev.Pa.20.040180.002133  0.434
1980 Gambertoglio JG, Amend WJC, Benet LZ. Pharmacokinetics and bioavailability of prednisone and prednisolone in healthy volunteers and patients: A review Journal of Pharmacokinetics and Biopharmaceutics. 8: 1-52. PMID 6991663 DOI: 10.1007/Bf01059447  0.309
1980 Smith DE, Benet LZ. Relationship between urinary excretion rate, steady-state plasma levels and diuretic response of furosemide in the rat. Pharmacology. 19: 301-6. PMID 549032 DOI: 10.1159/000137329  0.337
1980 Greither A, Goldman S, Edelen JS, Benet LZ, Cohn K. Pharmacokinetics of furosemide in patients with congestive heart failure. Pharmacology. 19: 121-31. PMID 523503 DOI: 10.1159/000137299  0.377
1980 Ding TL, Benet LZ. Determination of 6-mercaptopurine and azathioprine in plasma by high-performance liquid chromatography. Journal of Chromatography. 163: 281-8. PMID 120373 DOI: 10.1016/S0378-4347(00)81415-2  0.302
1980 Øie S, Benet LZ. Chapter 29. Altered Drug Disposition in Disease States Annual Reports in Medicinal Chemistry. 15: 277-287. DOI: 10.1016/S0065-7743(08)60390-5  0.408
1979 Benet LZ. Effect of route of administration and distribution on drug action. Journal of Pharmacokinetics and Biopharmaceutics. 6: 559-85. PMID 731418 DOI: 10.1007/Bf01062110  0.434
1979 Till AE, Benet LZ. Pseudoephedrine pharmacokinetics in the rat using a microanalysis technique. Pharmacology. 18: 306-10. PMID 493335 DOI: 10.1159/000137270  0.323
1979 Smith DE, Brater DC, Lin ET, Benet LZ. Attenuation of furosemide's diuretic effect by indomethacin: pharmacokinetic evaluation. Journal of Pharmacokinetics and Biopharmaceutics. 7: 265-74. PMID 480148 DOI: 10.1007/Bf01060017  0.338
1979 Benet LZ. Pharmacokinetics/pharmacodynamics of furosemide in man: a review. Journal of Pharmacokinetics and Biopharmaceutics. 7: 1-27. PMID 458552 DOI: 10.1007/Bf01059438  0.313
1979 Frey FJ, Frey BM, Benet LZ. Liquid-chromatographic measurement of endogenous and exogenous glucocorticoids in plasma. Clinical Chemistry. 25: 1944-1947. DOI: 10.1093/Clinchem/25.11.1944  0.328
1978 Aziz NS, Gambertoglio JG, Lin ET, Grausz H, Benet LZ. Pharmacokinetics of cefamandole using a HPLC assay. Journal of Pharmacokinetics and Biopharmaceutics. 6: 153-64. PMID 671221 DOI: 10.1007/Bf01117449  0.324
1978 Lee CS, Benet LZ. Micro and macro GLC determination of ethambutol in biological fluids. Journal of Pharmaceutical Sciences. 67: 470-3. PMID 641750 DOI: 10.1002/Jps.2600670407  0.303
1978 Stalker NE, Gambertoglio JG, Fukumitsu CJ, Naughton JL, Benet LZ. Acute massive chloral hydrate intoxication treated with hemodialysis: a clinical pharmacokinetic analysis. Journal of Clinical Pharmacology. 18: 136-42. PMID 624775 DOI: 10.1002/J.1552-4604.1978.Tb02434.X  0.301
1977 Lee CS, Gambertoglio JG, Brater DC, Benet LZ. Kinetics of oral ethambutol in the normal subject. Clinical Pharmacology and Therapeutics. 22: 615-21. PMID 410579 DOI: 10.1002/Cpt1977225Part1615  0.336
1976 Galeazzi RL, Benet LZ. Inappropriate use of the law of corresponding areas to calculate the time course of absorption for multicompartmental systems. Journal of Pharmacokinetics and Biopharmaceutics. 4: 43-56. PMID 1271239 DOI: 10.1007/Bf01271443  0.383
1976 Pagliaro LA, Benet LZ. Critical compilation of terminal half-lives, percent excreted unchanged, and changes of half-life in renal and hepatic dysfunction for studies in humans with references. Journal of Pharmacokinetics and Biopharmaceutics. 3: 333-83. PMID 1107513 DOI: 10.1007/Bf01082306  0.312
1976 Galeazzi RL, Benet LZ, Sheiner LB. Relationship between the pharmacokinetics and pharmacodynamics of procainamide Clinical Pharmacology and Therapeutics. 20: 278-289. PMID 954350 DOI: 10.1002/Cpt1976203278  0.408
1975 Till AE, Benet LZ, Kwan KC. An integrated approach to the pharmacokinetic analysis of drug absorption. Journal of Pharmacokinetics and Biopharmaceutics. 2: 525-44. PMID 4461782 DOI: 10.1007/Bf01070946  0.374
1975 Gustafson JH, Benet LZ. Biliary excretion kinetics of phenolphthalein glucuronide after intravenous and retrograde biliary administration. The Journal of Pharmacy and Pharmacology. 26: 937-44. PMID 4156858 DOI: 10.1111/J.2042-7158.1974.Tb09212.X  0.339
1975 Orr JM, Benet LZ. The effect of fasting on the rate of intestinal drug absorption in rats: preliminary studies. The American Journal of Digestive Diseases. 20: 858-65. PMID 1163521 DOI: 10.1007/Bf01070955  0.353
1975 Till AE, Benet LZ, Kwan KC. Erratum to: An integrated approach to the pharmacokinetic analysis of drug absorption Journal of Pharmacokinetics and Biopharmaceutics. 3: 291-291. DOI: 10.1007/Bf01066924  0.374
1974 Rowland M, Benet LZ, Graham GG. Clearance concepts in pharmacokinetics. Journal of Pharmacokinetics and Biopharmaceutics. 1: 123-36. PMID 4764426 DOI: 10.1007/Bf01059626  0.376
1974 Nayak RK, Benet LZ. Use of the unanesthetized rhesus monkey as a model for studying the gastrointestinal absorption of drugs Journal of Pharmacokinetics and Biopharmaceutics. 2: 417-431. PMID 4452944 DOI: 10.1007/Bf01071311  0.394
1973 Wolfe DL, Forland SC, Benet LZ. Drug transfer across intact rat intestinal mucosa following surgical removal of serosa and muscularis externa Journal of Pharmaceutical Sciences. 62: 200-205. PMID 4686389 DOI: 10.1002/Jps.2600620203  0.304
1972 Benet LZ. General treatment of linear mammillary models with elimination from any compartment as used in pharmacokinetics. Journal of Pharmaceutical Sciences. 61: 536-41. PMID 5014309 DOI: 10.1002/Jps.2600610408  0.344
1972 Benet LZ. Chapter 24. Biopharmaceutics and Pharmacokinetics Annual Reports in Medicinal Chemistry. 7: 259-268. DOI: 10.1016/S0065-7743(08)60819-2  0.461
1971 Benet LZ, Orr JM, Turner RH, Webb HS. Effect of buffer constituents and time on drug transfer across in vitro rat intestine. Journal of Pharmaceutical Sciences. 60: 234-8. PMID 5572446 DOI: 10.1002/Jps.2600600216  0.327
1971 Nayak RK, Benet LZ. Drug transfer across rat intestinal musculature after edetic acid treatment Journal of Pharmaceutical Sciences. 60: 1508-1511. PMID 5001965 DOI: 10.1002/Jps.2600601014  0.3
1971 Benet LZ. Chapter 26. Biopharmaceutics and Pharmacokinetics Annual Reports in Medicinal Chemistry. 6: 264-273. DOI: 10.1016/S0065-7743(08)60981-1  0.426
1970 Turner RH, Mehta CS, Benet LZ. Apparent directional permeability coefficients for drug ions: in vitro intestinal perfusion studies Journal of Pharmaceutical Sciences. 59: 590-595. PMID 5446410 DOI: 10.1002/Jps.2600590503  0.409
1970 Rowland M, Benet LZ, Riegelman S. Two-compartment model for a drug and its metabolite: application to acetylsalicylic acid pharmacokinetics. Journal of Pharmaceutical Sciences. 59: 364-7. PMID 5416180 DOI: 10.1002/Jps.2600590319  0.358
1966 Singh P, Guillory JK, Sokoloski TD, Benet LZ, Bhatia VN. Effect of inert tablet ingredients on drug absorption. I. Effect of polyethylene glycol 4000 on the intestinal absorption of four barbiturates. Journal of Pharmaceutical Sciences. 55: 63-8. PMID 5918653 DOI: 10.1002/Jps.2600550114  0.321
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