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David Y. Huang, MD/PhD - Publications

2002- Neurology University of North Carolina, Chapel Hill, Chapel Hill, NC 
Stroke, Alzheimer's disease, neurodegeneration

63 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Pan YG, Huang MT, Sekar P, Huang DY, Lin WW, Hsieh SL. Decoy Receptor 3 Inhibits Monosodium Urate-Induced NLRP3 Inflammasome Activation Reduction of Reactive Oxygen Species Production and Lysosomal Rupture. Frontiers in Immunology. 12: 638676. PMID 33746978 DOI: 10.3389/fimmu.2021.638676  0.4
2020 Chan CM, Sekar P, Huang DY, Hsu SH, Lin WW. Different Effects of Metformin and A769662 on Sodium Iodate-Induced Cytotoxicity in Retinal Pigment Epithelial Cells: Distinct Actions on Mitochondrial Fission and Respiration. Antioxidants (Basel, Switzerland). 9. PMID 33126710 DOI: 10.3390/antiox9111057  0.4
2020 Huang DY, Chen WY, Chen CL, Wu NL, Lin WW. Synergistic Anti-Tumour Effect of Syk Inhibitor and Olaparib in Squamous Cell Carcinoma: Roles of Syk in EGFR Signalling and PARP1 Activation. Cancers. 12. PMID 32093123 DOI: 10.3390/cancers12020489  0.4
2019 Chan CM, Huang DY, Sekar P, Hsu SH, Lin WW. Correction to: Reactive oxygen species-dependent mitochondrial dynamics and autophagy confer protective effects in retinal pigment epithelial cells against sodium iodate-induced cell death. Journal of Biomedical Science. 26: 66. PMID 31481051 DOI: 10.1186/s12929-019-0555-4  0.4
2019 Chan CM, Huang DY, Sekar P, Hsu SH, Lin WW. Reactive oxygen species-dependent mitochondrial dynamics and autophagy confer protective effects in retinal pigment epithelial cells against sodium iodate-induced cell death. Journal of Biomedical Science. 26: 40. PMID 31118030 DOI: 10.1186/s12929-019-0531-z  0.4
2018 Sekar P, Huang DY, Hsieh SL, Chang SF, Lin WW. AMPK-dependent and independent actions of P2X7 in regulation of mitochondrial and lysosomal functions in microglia. Cell Communication and Signaling : Ccs. 16: 83. PMID 30458799 DOI: 10.1186/s12964-018-0293-3  0.4
2018 Chang HC, Huang DY, Wu NL, Kannagi R, Wang LF, Lin WW. BLIMP1 transcriptionally induced by EGFR activation and post-translationally regulated by proteasome and lysosome is involved in keratinocyte differentiation, migration and inflammation. Journal of Dermatological Science. PMID 30197274 DOI: 10.1016/j.jdermsci.2018.08.011  0.4
2018 Sekar P, Huang DY, Chang SF, Lin WW. Coordinate effects of P2X7 and extracellular acidification in microglial cells. Oncotarget. 9: 12718-12731. PMID 29560104 DOI: 10.18632/oncotarget.24331  0.4
2017 Jhou JP, Chen SJ, Huang HY, Lin WW, Huang DY, Tzeng SJ. Upregulation of FcγRIIB by resveratrol via NF-κB activation reduces B-cell numbers and ameliorates lupus. Experimental & Molecular Medicine. 49: e381. PMID 28960214 DOI: 10.1038/Emm.2017.144  0.4
2017 Chang HC, Huang DY, Wu MS, Chu CL, Tzeng SJ, Lin WW. Spleen tyrosine kinase mediates the actions of EPO and GM-CSF and coordinates with TGF-β in erythropoiesis. Biochimica Et Biophysica Acta. PMID 28131718 DOI: 10.1016/j.bbamcr.2017.01.014  0.4
2016 Chan CM, Huang DY, Huang YP, Hsu SH, Kang LY, Shen CM, Lin WW. Methylglyoxal induces cell death through endoplasmic reticulum stress-associated ROS production and mitochondrial dysfunction. Journal of Cellular and Molecular Medicine. PMID 27307396 DOI: 10.1111/jcmm.12893  0.4
2016 Wu NL, Huang DY, Wang LF, Kannagi R, Fan YC, Lin WW. Spleen Tyrosine Kinase Mediates EGFR Signaling to Regulate Keratinocyte Terminal Differentiation. The Journal of Investigative Dermatology. 136: 192-201. PMID 26763439 DOI: 10.1038/JID.2015.381  0.4
2015 Wu NL, Huang DY, Wang LF, Kannagi R, Fan YC, Lin WW. Spleen Tyrosine Kinase Mediates EGFR Signaling to Regulate Keratinocyte Terminal Differentiation. The Journal of Investigative Dermatology. PMID 26422383 DOI: 10.1038/jid.2015.381  0.4
2015 Wang JS, Wu D, Huang DY, Lin WW. TAK1 inhibition-induced RIP1-dependent apoptosis in murine macrophages relies on constitutive TNF-α signaling and ROS production. Journal of Biomedical Science. 22: 76. PMID 26381601 DOI: 10.1186/s12929-015-0182-7  0.4
2015 Lin KC, Huang DY, Huang DW, Tzeng SJ, Lin WW. Inhibition of AMPK through Lyn-Syk-Akt enhances FcεRI signal pathways for allergic response. Journal of Molecular Medicine (Berlin, Germany). PMID 26373430 DOI: 10.1007/s00109-015-1339-2  0.4
2015 Chen KT, Huang DY, Chiu CH, Lin WW, Liang PH, Cheng WC. Synthesis of Diverse N-Substituted Muramyl Dipeptide Derivatives and Their Use in a Study of Human NOD2 Stimulation Activity. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 11984-8. PMID 26226896 DOI: 10.1002/Chem.201501557  0.4
2015 Lin YC, Huang DY, Wang JS, Lin YL, Hsieh SL, Huang KC, Lin WW. Syk is involved in NLRP3 inflammasome-mediated caspase-1 activation through adaptor ASC phosphorylation and enhanced oligomerization. Journal of Leukocyte Biology. PMID 25605870 DOI: 10.1189/jlb.3HI0814-371RR  0.4
2015 Chen PT, Lin CK, Tsai CJ, Huang DY, Nien FY, Lin WW, Cheng WC. Expeditious synthesis of enantiopure, orthogonally protected bis-α-amino acids (OPBAAs) and their use in a study of Nod1 stimulation. Chemistry, An Asian Journal. 10: 474-82. PMID 25504924 DOI: 10.1002/Asia.201403173  0.4
2015 Wu NL, Huang DY, Tsou HN, Lin YC, Lin WW. Syk mediates IL-17-induced CCL20 expression by targeting Act1-dependent K63-linked ubiquitination of TRAF6. The Journal of Investigative Dermatology. 135: 490-8. PMID 25202827 DOI: 10.1038/jid.2014.383  0.4
2014 Hacke W, Schellinger PD, Albers GW, Bornstein NM, Dahlof BL, Fulton R, Kasner SE, Shuaib A, Richieri SP, Dilly SG, Zivin J, Lees KR. Transcranial laser therapy in acute stroke treatment: results of neurothera effectiveness and safety trial 3, a phase III clinical end point device trial. Stroke; a Journal of Cerebral Circulation. 45: 3187-93. PMID 25293665 DOI: 10.1161/Strokeaha.114.005795  1
2014 Wu CA, Huang DY, Lin WW. Beclin-1-independent autophagy positively regulates internal ribosomal entry site-dependent translation of hypoxia-inducible factor 1α under nutrient deprivation. Oncotarget. 5: 7525-39. PMID 25115400  0.4
2014 Huang CT, Huang DY, Hu CJ, Wu D, Lin WW. Energy adaptive response during parthanatos is enhanced by PD98059 and involves mitochondrial function but not autophagy induction. Biochimica Et Biophysica Acta. 1843: 531-43. PMID 24321770 DOI: 10.1016/j.bbamcr.2013.12.001  0.4
2014 Lin TY, Chen CF, Huang DY, Huang CW, Chen GD. Using resource of classroom and content of textbook to build immersive interactive learning playground Proceedings - Ieee 14th International Conference On Advanced Learning Technologies, Icalt 2014. 244-248. DOI: 10.1109/ICALT.2014.78  0.36
2014 Li WH, Huang SY, Lien CL, Huang DY, Huang CW, Yang SH, Chen GD. Using learning portfolio platform to enhance altruistic behaviors Proceedings - Ieee 14th International Conference On Advanced Learning Technologies, Icalt 2014. 488-492. DOI: 10.1109/ICALT.2014.144  0.36
2014 Dai WC, Chiu SJ, Huang DY, Juan HY, Chen CY, Chen SS, Su CH, Li SY. Lipase-catalyzed synthesis of butyl propionate in solvent-free system: Optimization by response surface methodology Journal of the Taiwan Institute of Chemical Engineers. 45: 2233-2237. DOI: 10.1016/j.jtice.2014.05.007  0.32
2014 Luo YF, Lin WC, Lin TY, Huang DY, Huang CW, Chen GD. Learning cinema authoring system in the classroom Proceedings of the 22nd International Conference On Computers in Education, Icce 2014. 355-360.  0.36
2014 Wang SY, Li WH, Huang DY, Huang CW, Yang SH, Chen GD. Altruistic behavior in a learning stage through social network Proceedings of the 22nd International Conference On Computers in Education, Icce 2014. 313-318.  0.36
2013 Tu YC, Huang DY, Shiah SG, Wang JS, Lin WW. Regulation of c-Fos gene expression by NF-κB: a p65 homodimer binding site in mouse embryonic fibroblasts but not human HEK293 cells. Plos One. 8: e84062. PMID 24386331 DOI: 10.1371/journal.pone.0084062  0.4
2013 Huang DY, Eisert WG. CHANCE trial: early short-term dual antiplatelet treatment for stroke prevention. Stroke; a Journal of Cerebral Circulation. 44: 3623-4. PMID 24253544 DOI: 10.1161/STROKEAHA.113.003380  1
2013 Lin YC, Huang DY, Chu CL, Lin YL, Lin WW. The tyrosine kinase Syk differentially regulates Toll-like receptor signaling downstream of the adaptor molecules TRAF6 and TRAF3. Science Signaling. 6: ra71. PMID 23962979 DOI: 10.1126/scisignal.2003973  0.4
2013 Schellinger PD, Shuaib A, Köhrmann M, Liebeskind DS, Jovin T, Hammer MD, Sen S, Huang DY, Solander S, Gupta R, Leker RR, Saver JL. Reduced mortality and severe disability rates in the SENTIS trial. Ajnr. American Journal of Neuroradiology. 34: 2312-6. PMID 23828106 DOI: 10.3174/ajnr.A3613  1
2013 Wu NL, Huang DY, Hsieh SL, Hsiao CH, Lee TA, Lin WW. EGFR-driven up-regulation of decoy receptor 3 in keratinocytes contributes to the pathogenesis of psoriasis. Biochimica Et Biophysica Acta. 1832: 1538-48. PMID 23707413 DOI: 10.1016/j.bbadis.2013.05.020  0.4
2013 Vinikoor MJ, Napravnik S, Floris-Moore M, Wilson S, Huang DY, Eron JJ. Incidence and clinical features of cerebrovascular disease among HIV-infected adults in the Southeastern United States. Aids Research and Human Retroviruses. 29: 1068-74. PMID 23565888 DOI: 10.1089/Aid.2012.0334  1
2013 Shuaib A, Schwab S, Rutledge JN, Starkman S, Liebeskind DS, Bernardini GL, Boulos A, Abou-Chebl A, Huang DY, Vanhooren G, Cruz-Flores S, Klucznik RP, Saver JL. Importance of proper patient selection and endpoint selection in evaluation of new therapies in acute stroke: further analysis of the SENTIS trial. Journal of Neurointerventional Surgery. 5: i21-4. PMID 23291425 DOI: 10.1136/Neurintsurg-2012-010562  1
2012 Chang MY, Huang DY, Ho FM, Huang KC, Lin WW. PKC-dependent human monocyte adhesion requires AMPK and Syk activation. Plos One. 7: e40999. PMID 22848421 DOI: 10.1371/journal.pone.0040999  0.4
2012 Ho HJ, Huang DY, Ho FM, Lee LT, Lin WW. Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase expression by endoplasmic reticulum stress. Cellular Signalling. 24: 2166-78. PMID 22841895 DOI: 10.1016/j.cellsig.2012.07.018  0.4
2012 Huang DY, Chao Y, Tai MH, Yu YH, Lin WW. STI571 reduces TRAIL-induced apoptosis in colon cancer cells: c-Abl activation by the death receptor leads to stress kinase-dependent cell death. Journal of Biomedical Science. 19: 35. PMID 22462553 DOI: 10.1186/1423-0127-19-35  0.4
2011 Tsai WH, Huang DY, Yu YH, Chen CY, Lin WW. Dual roles of NOD2 in TLR4-mediated signal transduction and -induced inflammatory gene expression in macrophages. Cellular Microbiology. 13: 717-30. PMID 21199260 DOI: 10.1111/j.1462-5822.2010.01567.x  0.4
2010 Lin YC, Huang DY, Chu CL, Lin WW. Anti-inflammatory actions of Syk inhibitors in macrophages involve non-specific inhibition of toll-like receptors-mediated JNK signaling pathway. Molecular Immunology. 47: 1569-78. PMID 20138367 DOI: 10.1016/j.molimm.2010.01.008  0.4
2010 Anderson LG, Meeker RB, Poulton WE, Huang DY. Brain distribution of carboxy terminus of Hsc70-interacting protein (CHIP) and its nuclear translocation in cultured cortical neurons following heat stress or oxygen-glucose deprivation. Cell Stress & Chaperones. 15: 487-95. PMID 19953350 DOI: 10.1007/S12192-009-0162-5  1
2010 Aucutt-Walter N, Jewells V, Huang DY. Neurology Practical Hemostasis and Thrombosis: Second Edition. 209-217. DOI: 10.1002/9781444306286.ch20  1
2009 Hwang ES, Zhang Z, Cai H, Huang DY, Huong SM, Cha CY, Huang ES. Human cytomegalovirus IE1-72 protein interacts with p53 and inhibits p53-dependent transactivation by a mechanism different from that of IE2-86 protein. Journal of Virology. 83: 12388-98. PMID 19776115 DOI: 10.1128/Jvi.00304-09  1
2009 Sen S, Huang DY, Akhavan O, Wilson S, Verro P, Solander S. IV vs. IA TPA in acute ischemic stroke with CT angiographic evidence of major vessel occlusion: a feasibility study. Neurocritical Care. 11: 76-81. PMID 19277904 DOI: 10.1007/s12028-009-9204-1  1
2008 Su RY, Chi KH, Huang DY, Tai MH, Lin WW. 15-deoxy-Delta12,14-prostaglandin J2 up-regulates death receptor 5 gene expression in HCT116 cells: involvement of reactive oxygen species and C/EBP homologous transcription factor gene transcription. Molecular Cancer Therapeutics. 7: 3429-40. PMID 18852146 DOI: 10.1158/1535-7163.MCT-08-0498  0.4
2007 Su RY, Chao Y, Chen TY, Huang DY, Lin WW. 5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- and TNF{alpha}-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling. Molecular Cancer Therapeutics. 6: 1562-71. PMID 17513605 DOI: 10.1158/1535-7163.MCT-06-0800  0.4
2005 Dai Q, Qian SB, Li HH, McDonough H, Borchers C, Huang D, Takayama S, Younger JM, Ren HY, Cyr DM, Patterson C. Regulation of the cytoplasmic quality control protein degradation pathway by BAG2. The Journal of Biological Chemistry. 280: 38673-81. PMID 16169850 DOI: 10.1074/Jbc.M507986200  1
2005 Wang X, Huang DY, Huong SM, Huang ES. Integrin alphavbeta3 is a coreceptor for human cytomegalovirus. Nature Medicine. 11: 515-21. PMID 15834425 DOI: 10.1038/nm1236  1
2004 Evers DL, Wang X, Huong SM, Huang DY, Huang ES. 3,4',5-Trihydroxy-trans-stilbene (resveratrol) inhibits human cytomegalovirus replication and virus-induced cellular signaling. Antiviral Research. 63: 85-95. PMID 15302137 DOI: 10.1016/J.Antiviral.2004.03.002  1
2003 Zhang Z, Huong SM, Wang X, Huang DY, Huang ES. Interactions between human cytomegalovirus IE1-72 and cellular p107: functional domains and mechanisms of up-regulation of cyclin E/cdk2 kinase activity. Journal of Virology. 77: 12660-70. PMID 14610188 DOI: 10.1128/Jvi.77.23.12660-12670.2003  1
1999 Hu PPC, Shen X, Huang D, Liu Y, Counter C, Wang XF. The MEK pathway is required for stimulation of p21(WAF1/CIP1) by transforming growth factor-β Journal of Biological Chemistry. 274: 35381-35387. PMID 10585406 DOI: 10.1074/Jbc.274.50.35381  1
1996 Strittmatter WJ, Burke JR, DeSerrano VS, Huang DY, Matthew W, Saunders AM, Scott BL, Vance JM, Weisgraber KH, Roses AD. Protein: protein interactions in Alzheimer's disease and the CAG triplet repeat diseases. Cold Spring Harbor Symposia On Quantitative Biology. 61: 597-605. PMID 9246486 DOI: 10.1101/Sqb.1996.061.01.060  1
1996 Montine TJ, Huang DY, Valentine WM, Amarnath V, Saunders A, Weisgraber KH, Graham DG, Strittmatter WJ. Crosslinking of apolipoprotein E by products of lipid peroxidation. Journal of Neuropathology and Experimental Neurology. 55: 202-10. PMID 8786379 DOI: 10.1097/00005072-199602000-00009  1
1996 Roses AD, Einstein G, Gilbert J, Goedert M, Han SH, Huang D, Hulette C, Masliah E, Pericak-Vance MA, Saunders AM, Schmechel DE, Strittmatter WJ, Weisgraber KH, Xi PT. Morphological, biochemical, and genetic support for an apolipoprotein E effect on microtubular metabolism. Annals of the New York Academy of Sciences. 777: 146-57. PMID 8624078 DOI: 10.1111/J.1749-6632.1996.Tb34413.X  1
1995 Roses AD, Saunders AM, Corder EH, Pericak-Vance MA, Han SH, Einstein G, Hulette C, Schmechel DE, Holsti M, Huang D. Influence of the susceptibility genes apolipoprotein E-epsilon 4 and apolipoprotein E-epsilon 2 on the rate of disease expressivity of late-onset Alzheimer's disease. Arzneimittel-Forschung. 45: 413-7. PMID 7763336  1
1995 Huang DY, Weisgraber KH, Goedert M, Saunders AM, Roses AD, Strittmatter WJ. ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation. Neuroscience Letters. 192: 209-12. PMID 7566652 DOI: 10.1016/0304-3940(95)11649-H  1
1995 Huang DY, Weisgraber KH, Strittmatter WJ, Matthew WD. Interaction of apolipoprotein E with laminin increases neuronal adhesion and alters neurite morphology. Experimental Neurology. 136: 251-7. PMID 7498414 DOI: 10.1006/Exnr.1995.1101  1
1994 Strittmatter WJ, Weisgraber KH, Goedert M, Saunders AM, Huang D, Corder EH, Dong LM, Jakes R, Alberts MJ, Gilbert JR. Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype. Experimental Neurology. 125: 163-71; discussion 1. PMID 8313935 DOI: 10.1006/Exnr.1994.1019  1
1994 Sanan DA, Weisgraber KH, Russell SJ, Mahley RW, Huang D, Saunders A, Schmechel D, Wisniewski T, Frangione B, Roses AD. Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3. The Journal of Clinical Investigation. 94: 860-9. PMID 8040342 DOI: 10.1172/Jci117407  1
1994 Strittmatter WJ, Saunders AM, Goedert M, Weisgraber KH, Dong LM, Jakes R, Huang DY, Pericak-Vance M, Schmechel D, Roses AD. Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 91: 11183-6. PMID 7972031 DOI: 10.1073/Pnas.91.23.11183  1
1994 Huang DY, Goedert M, Jakes R, Weisgraber KH, Garner CC, Saunders AM, Pericak-Vance MA, Schmechel DE, Roses AD, Strittmatter WJ. Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease. Neuroscience Letters. 182: 55-8. PMID 7891887 DOI: 10.1016/0304-3940(94)90204-6  1
1993 Strittmatter WJ, Huang DY, Bhasin R, Roses AD, Goldgaber D. Avid binding of beta A amyloid peptide to its own precursor. Experimental Neurology. 122: 327-34. PMID 8405269 DOI: 10.1006/Exnr.1993.1132  1
1993 Strittmatter WJ, Weisgraber KH, Huang DY, Dong LM, Salvesen GS, Pericak-Vance M, Schmechel D, Saunders AM, Goldgaber D, Roses AD. Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 90: 8098-102. PMID 8367470 DOI: 10.1073/Pnas.90.17.8098  1
1993 Huang D, Martin M, Hu D, Roses AD, Goldgaber D, Strittmatter WJ. Binding of IgG to amyloid beta A4 peptide via the heavy-chain hinge region with preservation of antigen binding. Journal of Neuroimmunology. 48: 199-203. PMID 8227317 DOI: 10.1016/0165-5728(93)90192-2  1
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