| Year |
Citation |
Score |
| 2023 |
Kegulian NC, Langen R, Moradian-Oldak J. The Dynamic Interactions of a Multitargeting Domain in Ameloblastin Protein with Amelogenin and Membrane. International Journal of Molecular Sciences. 24. PMID 36834897 DOI: 10.3390/ijms24043484 |
0.357 |
|
| 2021 |
Okada AK, Teranishi K, Ambroso MR, Isas JM, Vazquez-Sarandeses E, Lee JY, Melo AA, Pandey P, Merken D, Berndt L, Lammers M, Daumke O, Chang K, Haworth IS, Langen R. Lysine acetylation regulates the interaction between proteins and membranes. Nature Communications. 12: 6466. PMID 34753925 DOI: 10.1038/s41467-021-26657-2 |
0.351 |
|
| 2020 |
Varkey J, Zhang J, Kim J, George G, He G, Belov G, Langen R, Wang X. An Amphipathic Alpha-Helix Domain from Poliovirus 2C Protein Tubulate Lipid Vesicles. Viruses. 12. PMID 33353144 DOI: 10.3390/v12121466 |
0.348 |
|
| 2020 |
Lo CH, Pandey NK, Lim CK, Ding Z, Tao M, Thomas D, Langen R, Sachs JN. Discovery of small molecule inhibitors of huntingtin exon 1 aggregation by FRET-based high-throughput screening in living cells. Acs Chemical Neuroscience. PMID 32568514 DOI: 10.1021/Acschemneuro.0C00226 |
0.317 |
|
| 2020 |
Tao M, Isas JM, Langen R. Annexin B12 Trimer Formation is Governed by a Network of Protein-Protein and Protein-Lipid Interactions. Scientific Reports. 10: 5301. PMID 32210350 DOI: 10.1038/S41598-020-62343-X |
0.447 |
|
| 2020 |
Cervantes Cortes SA, Isas JM, Kirstein J, Langen R, Siemer AB. Structural Characterization of Huntingtin: Mechanism of Aggregation and Disaggregation Biophysical Journal. 118: 216a. DOI: 10.1016/J.Bpj.2019.11.1285 |
0.337 |
|
| 2019 |
Tao M, Pandey NK, Barnes R, Han S, Langen R. Structure of Membrane-Bound Huntingtin Exon 1 Reveals Membrane Interaction and Aggregation Mechanisms. Structure (London, England : 1993). PMID 31466833 DOI: 10.1016/J.Str.2019.08.003 |
0.493 |
|
| 2019 |
Levine ZA, Teranishi K, Okada AK, Langen R, Shea JE. The Mitochondrial Peptide Humanin Targets, but does not Denature Amyloid Oligomers in Type II Diabetes. Journal of the American Chemical Society. PMID 31456396 DOI: 10.1021/Jacs.9B04995 |
0.378 |
|
| 2019 |
Rovere M, Powers AE, Jiang H, Pitino JC, Fonseca-Ornelas L, Patel DS, Achille A, Langen R, Varkey J, Bartels T. E46K-like α-synuclein mutants increase lipid interactions and disrupt membrane selectivity. The Journal of Biological Chemistry. PMID 31048377 DOI: 10.1074/Jbc.Ra118.006551 |
0.413 |
|
| 2019 |
Vasquez-Montes V, Vargas-Uribe M, Pandey NK, Rodnin MV, Langen R, Ladokhin AS. Lipid-modulation of membrane insertion and refolding of the apoptotic inhibitor Bcl-xL. Biochimica Et Biophysica Acta. Proteins and Proteomics. PMID 31004798 DOI: 10.1016/J.Bbapap.2019.04.006 |
0.463 |
|
| 2018 |
Kahraman O, Langen R, Haselwandter CA. Directed Supramolecular Organization of N-BAR Proteins through Regulation of H0 Membrane Immersion Depth. Scientific Reports. 8: 16383. PMID 30401832 DOI: 10.1038/S41598-018-34273-2 |
0.423 |
|
| 2018 |
Bravo-Arredondo JM, Kegulian NC, Schmidt T, Pandey NK, Situ AJ, Ulmer TS, Langen R. The Folding Equilibrium of Huntingtin Exon-1 Monomer Depends on its Polyglutamine Tract. The Journal of Biological Chemistry. PMID 30315108 DOI: 10.1074/Jbc.Ra118.004808 |
0.368 |
|
| 2018 |
Ko J, Isas JM, Sabbaugh A, Yoo JH, Pandey NK, Chongtham A, Ladinsky M, Wu WL, Rohweder H, Weiss A, Macdonald D, Munoz-Sanjuan I, Langen R, Patterson PH, Khoshnan A. Identification of distinct conformations associated with monomers and fibril assemblies of mutant huntingtin. Human Molecular Genetics. PMID 29912367 DOI: 10.1093/Hmg/Ddy141 |
0.393 |
|
| 2018 |
Rawat A, Langen R, Varkey J. Membranes as modulators of amyloid protein misfolding and target of toxicity. Biochimica Et Biophysica Acta. PMID 29702073 DOI: 10.1016/J.Bbamem.2018.04.011 |
0.478 |
|
| 2018 |
Cervantes Cortes SA, Isas JM, Kirstein J, Langen R, Siemer AB. Structural Characterization of the Mechanism of Aggregation and Disaggregation of Huntingtin Biophysical Journal. 114: 427a. DOI: 10.1016/J.Bpj.2017.11.2369 |
0.337 |
|
| 2018 |
Langen R. Molecular Mechanisms of Membrane Remodeling Biophysical Journal. 114: 34a. DOI: 10.1016/J.Bpj.2017.11.235 |
0.388 |
|
| 2017 |
Pandey NK, Isas JM, Rawat A, Lee RV, Langen J, Pandey P, Langen R. The 17-residue-long N terminus in huntingtin controls step-wise aggregation in solution and on membranes via different mechanisms. The Journal of Biological Chemistry. PMID 29282287 DOI: 10.1074/Jbc.M117.813667 |
0.449 |
|
| 2017 |
Okada AK, Teranishi K, Lobo F, Isas JM, Xiao J, Yen K, Cohen P, Langen R. The Mitochondrial-Derived Peptides, HumaninS14G and Small Humanin-like Peptide 2, Exhibit Chaperone-like Activity. Scientific Reports. 7: 7802. PMID 28798389 DOI: 10.1038/S41598-017-08372-5 |
0.35 |
|
| 2017 |
Varkey J, Langen R. Membrane remodeling by amyloidogenic and non-amyloidogenic proteins studied by EPR. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 280: 127-139. PMID 28579098 DOI: 10.1016/J.Jmr.2017.02.014 |
0.491 |
|
| 2017 |
Melo AA, Hegde BG, Shah C, Larsson E, Isas JM, Kunz S, Lundmark R, Langen R, Daumke O. Structural insights into the activation mechanism of dynamin-like EHD ATPases. Proceedings of the National Academy of Sciences of the United States of America. PMID 28228524 DOI: 10.1073/Pnas.1614075114 |
0.481 |
|
| 2016 |
Cervantes SA, Bajakian TH, Soria MA, Falk AS, Service RJ, Langen R, Siemer AB. Identification and Structural Characterization of the N-terminal Amyloid Core of Orb2 isoform A. Scientific Reports. 6: 38265. PMID 27922050 DOI: 10.1038/Srep38265 |
0.362 |
|
| 2016 |
Fisette O, Päslack C, Barnes R, Isas JM, Langen R, Heyden M, Han S, Schäfer LV. Hydration dynamics of a peripheral membrane protein. Journal of the American Chemical Society. PMID 27548572 DOI: 10.1021/Jacs.6B07005 |
0.401 |
|
| 2016 |
Okada AK, Teranishi K, Isas JM, Bedrood S, Chow RH, Langen R. Diabetic Risk Factors Promote Islet Amyloid Polypeptide Misfolding by a Common, Membrane-mediated Mechanism. Scientific Reports. 6: 31094. PMID 27531121 DOI: 10.1038/Srep31094 |
0.782 |
|
| 2016 |
Levine ZA, Okada A, Teranishi K, Langen R, Shea J. Reducing IAPP Aggregation with Mitochondrial Humanin Peptides; Results from Simulations and Experiments Biophysical Journal. 110: 177a. DOI: 10.1016/J.Bpj.2015.11.990 |
0.366 |
|
| 2016 |
Kegulian NC, Isas MJ, Chung SS, Pandey NK, Bravo JM, Langen R. Conformational Shifts in Huntingtin Exon 1 Monomer are Dependent on Temperature and Polyglutamine Length Biophysical Journal. 110: 534a. DOI: 10.1016/J.Bpj.2015.11.2859 |
0.397 |
|
| 2016 |
Teranishi K, Okada A, Yen K, Cohen P, Langen R. Mitochondrially-Derived Peptides as Defense Against Amyloid Protein Misfolding Biophysical Journal. 110: 401a. DOI: 10.1016/J.Bpj.2015.11.2165 |
0.369 |
|
| 2016 |
Okada AK, Teranishi K, Chow RH, Langen R. Membrane-Mediated Misfolding of Islet Amyloid Polypeptide is a Shared Mechanism among Type 2 Diabetic Risk Factors Biophysical Journal. 110: 399a. DOI: 10.1016/J.Bpj.2015.11.2155 |
0.443 |
|
| 2016 |
Pandey NK, Mario Isas J, Langen R. Studies on Domain Specific Aggregation Behavior of Huntingtin Exon1 Biophysical Journal. 110: 214a. DOI: 10.1016/J.Bpj.2015.11.1190 |
0.368 |
|
| 2015 |
Dearborn AD, Wall JS, Cheng N, Heymann JB, Kajava AV, Varkey J, Langen R, Steven AC. α-Synuclein Amyloid Fibrils with Two Entwined, Asymmetrically Associated, Protofibrils. The Journal of Biological Chemistry. PMID 26644467 DOI: 10.1074/Jbc.M115.698787 |
0.343 |
|
| 2015 |
Marotta NP, Lin YH, Lewis YE, Ambroso MR, Zaro BW, Roth MT, Arnold DB, Langen R, Pratt MR. O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease. Nature Chemistry. 7: 913-20. PMID 26492012 DOI: 10.1038/Nchem.2361 |
0.327 |
|
| 2015 |
Beasley KN, Sutch BT, Hatmal MM, Langen R, Qin PZ, Haworth IS. Computer Modeling of Spin Labels: NASNOX, PRONOX, and ALLNOX. Methods in Enzymology. 563: 569-93. PMID 26478499 DOI: 10.1016/Bs.Mie.2015.07.021 |
0.303 |
|
| 2015 |
Ambroso MR, Haworth IS, Langen R. Structural Characterization of Membrane-Curving Proteins: Site-Directed Spin Labeling, EPR, and Computational Refinement. Methods in Enzymology. 564: 259-88. PMID 26477254 DOI: 10.1016/Bs.Mie.2015.07.002 |
0.486 |
|
| 2015 |
Kegulian NC, Sankhagowit S, Apostolidou M, Jayasinghe SA, Malmstadt N, Butler PC, Langen R. Membrane Curvature-Sensing and -Inducing Activity of Islet Amyloid Polypeptide and Its Implications for Membrane Disruption. The Journal of Biological Chemistry. PMID 26283787 DOI: 10.1074/Jbc.M115.659797 |
0.755 |
|
| 2015 |
Isas JM, Langen R, Siemer AB. Solid-State Nuclear Magnetic Resonance on the Static and Dynamic Domains of Huntingtin Exon-1 Fibrils. Biochemistry. 54: 3942-9. PMID 26020223 DOI: 10.1021/Acs.Biochem.5B00281 |
0.391 |
|
| 2015 |
Darrow MC, Sergeeva OA, Isas JM, Galaz-Montoya J, King JA, Langen R, Schmid MF, Chiu W. Structural Mechanisms of Mutant Huntingtin Aggregation Suppression by Synthetic Chaperonin-like CCT5 Complex Explained by Cryo-electron Tomography. The Journal of Biological Chemistry. PMID 25995452 DOI: 10.1074/Jbc.M115.655373 |
0.336 |
|
| 2015 |
Isas JM, Ambroso MR, Hegde PB, Langen J, Langen R. Tubulation by amphiphysin requires concentration-dependent switching from wedging to scaffolding. Structure (London, England : 1993). 23: 873-81. PMID 25865245 DOI: 10.1016/J.Str.2015.02.014 |
0.463 |
|
| 2015 |
Dearborn AD, Cheng N, Bernard Heymann J, Wall JS, Varkey J, Langen R, Steven AC. α-Synuclein Amyloid Fibrils Formed of Two Protofibrils Microscopy and Microanalysis. 21: 1285-1286. DOI: 10.1017/S1431927615007217 |
0.316 |
|
| 2014 |
Fodale V, Kegulian NC, Verani M, Cariulo C, Azzollini L, Petricca L, Daldin M, Boggio R, Padova A, Kuhn R, Pacifici R, Macdonald D, Schoenfeld RC, Park H, Isas JM, ... Langen R, et al. Polyglutamine- and temperature-dependent conformational rigidity in mutant huntingtin revealed by immunoassays and circular dichroism spectroscopy. Plos One. 9: e112262. PMID 25464275 DOI: 10.1371/Journal.Pone.0112262 |
0.359 |
|
| 2014 |
Lai Y, Kim S, Varkey J, Lou X, Song JK, Diao J, Langen R, Shin YK. Nonaggregated α-synuclein influences SNARE-dependent vesicle docking via membrane binding. Biochemistry. 53: 3889-96. PMID 24884175 DOI: 10.1021/Bi5002536 |
0.408 |
|
| 2014 |
Ambroso MR, Hegde BG, Langen R. Endophilin A1 induces different membrane shapes using a conformational switch that is regulated by phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 111: 6982-7. PMID 24778241 DOI: 10.1073/Pnas.1402233111 |
0.453 |
|
| 2014 |
Shah C, Hegde BG, Morén B, Behrmann E, Mielke T, Moenke G, Spahn CM, Lundmark R, Daumke O, Langen R. Structural insights into membrane interaction and caveolar targeting of dynamin-like EHD2. Structure (London, England : 1993). 22: 409-20. PMID 24508342 DOI: 10.1016/J.Str.2013.12.015 |
0.478 |
|
| 2013 |
Cheng CY, Varkey J, Ambroso MR, Langen R, Han S. Hydration dynamics as an intrinsic ruler for refining protein structure at lipid membrane interfaces. Proceedings of the National Academy of Sciences of the United States of America. 110: 16838-43. PMID 24082088 DOI: 10.1073/Pnas.1307678110 |
0.471 |
|
| 2013 |
Moaven H, Koike Y, Jao CC, Gurevich VV, Langen R, Chen J. Visual arrestin interaction with clathrin adaptor AP-2 regulates photoreceptor survival in the vertebrate retina. Proceedings of the National Academy of Sciences of the United States of America. 110: 9463-8. PMID 23690606 DOI: 10.1073/Pnas.1301126110 |
0.67 |
|
| 2013 |
Varkey J, Mizuno N, Hegde BG, Cheng N, Steven AC, Langen R. α-Synuclein oligomers with broken helical conformation form lipoprotein nanoparticles. The Journal of Biological Chemistry. 288: 17620-30. PMID 23609437 DOI: 10.1074/Jbc.M113.476697 |
0.382 |
|
| 2013 |
Dearborn A, Cheng N, Heymann J, Varkey J, Langen R, Steven A. α Synuclein Amyloid Fibrils With Two Entwined Protofibrils Each With One Subunit Per 4.7 Å Axial Rise Microscopy and Microanalysis. 19: 82-83. DOI: 10.1017/S1431927613002407 |
0.309 |
|
| 2013 |
Cheng C, Varkey J, Langen R, Han S. Hydration Dynamics as a Molecular Ruler for Refining Protein Structure at Lipid Membrane Interfaces Biophysical Journal. 104: 221a. DOI: 10.1016/j.bpj.2012.11.1246 |
0.314 |
|
| 2012 |
Ladiwala AR, Bhattacharya M, Perchiacca JM, Cao P, Raleigh DP, Abedini A, Schmidt AM, Varkey J, Langen R, Tessier PM. Rational design of potent domain antibody inhibitors of amyloid fibril assembly. Proceedings of the National Academy of Sciences of the United States of America. 109: 19965-70. PMID 23161913 DOI: 10.1073/Pnas.1208797109 |
0.342 |
|
| 2012 |
Li Y, Hatmal MM, Langen R, Haworth IS. Idealized models of protofilaments of human islet amyloid polypeptide. Journal of Chemical Information and Modeling. 52: 2983-91. PMID 23116372 DOI: 10.1021/Ci300300E |
0.365 |
|
| 2012 |
Lai CL, Jao CC, Lyman E, Gallop JL, Peter BJ, McMahon HT, Langen R, Voth GA. Membrane binding and self-association of the epsin N-terminal homology domain. Journal of Molecular Biology. 423: 800-17. PMID 22922484 DOI: 10.1016/J.Jmb.2012.08.010 |
0.739 |
|
| 2012 |
Bugg CW, Isas JM, Fischer T, Patterson PH, Langen R. Structural features and domain organization of huntingtin fibrils. The Journal of Biological Chemistry. 287: 31739-46. PMID 22801429 DOI: 10.1074/Jbc.M112.353839 |
0.412 |
|
| 2012 |
Mizuno N, Varkey J, Kegulian NC, Hegde BG, Cheng N, Langen R, Steven AC. Remodeling of lipid vesicles into cylindrical micelles by α-synuclein in an extended α-helical conformation. The Journal of Biological Chemistry. 287: 29301-11. PMID 22767608 DOI: 10.1074/Jbc.M112.365817 |
0.429 |
|
| 2012 |
Ruggiero L, Connor MP, Chen J, Langen R, Finnemann SC. Diurnal, localized exposure of phosphatidylserine by rod outer segment tips in wild-type but not Itgb5-/- or Mfge8-/- mouse retina. Proceedings of the National Academy of Sciences of the United States of America. 109: 8145-8. PMID 22566632 DOI: 10.1073/Pnas.1121101109 |
0.315 |
|
| 2012 |
Meier F, Abeywardana T, Dhall A, Marotta NP, Varkey J, Langen R, Chatterjee C, Pratt MR. Semisynthetic, site-specific ubiquitin modification of α-synuclein reveals differential effects on aggregation. Journal of the American Chemical Society. 134: 5468-71. PMID 22404520 DOI: 10.1021/Ja300094R |
0.355 |
|
| 2012 |
Krishnamani V, Hegde BG, Langen R, Lanyi JK. Secondary and tertiary structure of bacteriorhodopsin in the SDS denatured state. Biochemistry. 51: 1051-60. PMID 22242919 DOI: 10.1021/Bi201769Z |
0.374 |
|
| 2012 |
Bedrood S, Li Y, Isas JM, Hegde BG, Baxa U, Haworth IS, Langen R. Fibril structure of human islet amyloid polypeptide. The Journal of Biological Chemistry. 287: 5235-41. PMID 22187437 DOI: 10.1074/Jbc.M111.327817 |
0.784 |
|
| 2012 |
Hatmal MM, Li Y, Hegde BG, Hegde PB, Jao CC, Langen R, Haworth IS. Computer modeling of nitroxide spin labels on proteins. Biopolymers. 97: 35-44. PMID 21792846 DOI: 10.1002/Bip.21699 |
0.689 |
|
| 2011 |
Jensen MB, Bhatia VK, Jao CC, Rasmussen JE, Pedersen SL, Jensen KJ, Langen R, Stamou D. Membrane curvature sensing by amphipathic helices: a single liposome study using α-synuclein and annexin B12. The Journal of Biological Chemistry. 286: 42603-14. PMID 21953452 DOI: 10.1074/Jbc.M111.271130 |
0.753 |
|
| 2011 |
Richard JP, Leikina E, Langen R, Henne WM, Popova M, Balla T, McMahon HT, Kozlov MM, Chernomordik LV. Intracellular curvature-generating proteins in cell-to-cell fusion. The Biochemical Journal. 440: 185-93. PMID 21895608 DOI: 10.1042/Bj20111243 |
0.409 |
|
| 2011 |
Zhang QC, Yeh TL, Leyva A, Frank LG, Miller J, Kim YE, Langen R, Finkbeiner S, Amzel ML, Ross CA, Poirier MA. A compact beta model of huntingtin toxicity. The Journal of Biological Chemistry. 286: 8188-96. PMID 21209075 DOI: 10.1074/Jbc.M110.192013 |
0.54 |
|
| 2011 |
Langen R. Protein-Mediated Induction of Membrane Curvature Biophysical Journal. 100: 170a. DOI: 10.1016/J.Bpj.2010.12.1150 |
0.495 |
|
| 2010 |
Heinrich MC, Capraro BR, Tian A, Isas JM, Langen R, Baumgart T. Quantifying Membrane Curvature Generation of Drosophila Amphiphysin N-BAR Domains. The Journal of Physical Chemistry Letters. 1: 3401-3406. PMID 23772271 DOI: 10.1021/Jz101403Q |
0.423 |
|
| 2010 |
Daval M, Bedrood S, Gurlo T, Huang CJ, Costes S, Butler PC, Langen R. The effect of curcumin on human islet amyloid polypeptide misfolding and toxicity. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 17: 118-28. PMID 21067307 DOI: 10.3109/13506129.2010.530008 |
0.764 |
|
| 2010 |
Varkey J, Isas JM, Mizuno N, Jensen MB, Bhatia VK, Jao CC, Petrlova J, Voss JC, Stamou DG, Steven AC, Langen R. Membrane curvature induction and tubulation are common features of synucleins and apolipoproteins. The Journal of Biological Chemistry. 285: 32486-93. PMID 20693280 DOI: 10.1074/Jbc.M110.139576 |
0.755 |
|
| 2010 |
Kim YE, Chen J, Langen R, Chan JR. Monitoring apoptosis and neuronal degeneration by real-time detection of phosphatidylserine externalization using a polarity-sensitive indicator of viability and apoptosis. Nature Protocols. 5: 1396-405. PMID 20671723 DOI: 10.1038/Nprot.2010.101 |
0.485 |
|
| 2010 |
Rao JN, Jao CC, Hegde BG, Langen R, Ulmer TS. A combinatorial NMR and EPR approach for evaluating the structural ensemble of partially folded proteins. Journal of the American Chemical Society. 132: 8657-68. PMID 20524659 DOI: 10.1021/Ja100646T |
0.72 |
|
| 2010 |
Mizuno N, Jao CC, Langen R, Steven AC. Multiple modes of endophilin-mediated conversion of lipid vesicles into coated tubes: implications for synaptic endocytosis. The Journal of Biological Chemistry. 285: 23351-8. PMID 20484046 DOI: 10.1074/Jbc.M110.143776 |
0.721 |
|
| 2010 |
Jao CC, Hegde BG, Gallop JL, Hegde PB, McMahon HT, Haworth IS, Langen R. Roles of amphipathic helices and the bin/amphiphysin/rvs (BAR) domain of endophilin in membrane curvature generation. The Journal of Biological Chemistry. 285: 20164-70. PMID 20418375 DOI: 10.1074/Jbc.M110.127811 |
0.754 |
|
| 2010 |
Ladner CL, Chen M, Smith DP, Platt GW, Radford SE, Langen R. Stacked sets of parallel, in-register beta-strands of beta2-microglobulin in amyloid fibrils revealed by site-directed spin labeling and chemical labeling. The Journal of Biological Chemistry. 285: 17137-47. PMID 20335170 DOI: 10.1074/Jbc.M110.117234 |
0.335 |
|
| 2010 |
Wu JW, Breydo L, Isas JM, Lee J, Kuznetsov YG, Langen R, Glabe C. Fibrillar oligomers nucleate the oligomerization of monomeric amyloid beta but do not seed fibril formation. The Journal of Biological Chemistry. 285: 6071-9. PMID 20018889 DOI: 10.1074/Jbc.M109.069542 |
0.388 |
|
| 2010 |
Kim YE, Chen J, Chan JR, Langen R. Engineering a polarity-sensitive biosensor for time-lapse imaging of apoptotic processes and degeneration. Nature Methods. 7: 67-73. PMID 19966809 DOI: 10.1038/Nmeth.1405 |
0.467 |
|
| 2010 |
Isas JM, Luibl V, Johnson LV, Kayed R, Wetzel R, Glabe CG, Langen R, Chen J. Soluble and mature amyloid fibrils in drusen deposits. Investigative Ophthalmology & Visual Science. 51: 1304-10. PMID 19892876 DOI: 10.1167/Iovs.09-4207 |
0.34 |
|
| 2009 |
Bedrood S, Jayasinghe S, Sieburth D, Chen M, Erbel S, Butler PC, Langen R, Ritzel RA. Annexin A5 directly interacts with amyloidogenic proteins and reduces their toxicity. Biochemistry. 48: 10568-76. PMID 19810772 DOI: 10.1021/Bi900608M |
0.77 |
|
| 2008 |
Margittai M, Langen R. Fibrils with parallel in-register structure constitute a major class of amyloid fibrils: molecular insights from electron paramagnetic resonance spectroscopy. Quarterly Reviews of Biophysics. 41: 265-97. PMID 19079806 DOI: 10.1017/S0033583508004733 |
0.424 |
|
| 2008 |
Jao CC, Hegde BG, Chen J, Haworth IS, Langen R. Structure of membrane-bound alpha-synuclein from site-directed spin labeling and computational refinement. Proceedings of the National Academy of Sciences of the United States of America. 105: 19666-71. PMID 19066219 DOI: 10.1073/Pnas.0807826105 |
0.744 |
|
| 2008 |
Shin TM, Isas JM, Hsieh CL, Kayed R, Glabe CG, Langen R, Chen J. Formation of soluble amyloid oligomers and amyloid fibrils by the multifunctional protein vitronectin. Molecular Neurodegeneration. 3: 16. PMID 18939994 DOI: 10.1186/1750-1326-3-16 |
0.4 |
|
| 2008 |
Apostolidou M, Jayasinghe SA, Langen R. Structure of alpha-helical membrane-bound human islet amyloid polypeptide and its implications for membrane-mediated misfolding. The Journal of Biological Chemistry. 283: 17205-10. PMID 18442979 DOI: 10.1074/Jbc.M801383200 |
0.77 |
|
| 2007 |
Chen M, Margittai M, Chen J, Langen R. Investigation of alpha-synuclein fibril structure by site-directed spin labeling. The Journal of Biological Chemistry. 282: 24970-9. PMID 17573347 DOI: 10.1074/Jbc.M700368200 |
0.411 |
|
| 2007 |
Henne WM, Kent HM, Ford MG, Hegde BG, Daumke O, Butler PJ, Mittal R, Langen R, Evans PR, McMahon HT. Structure and analysis of FCHo2 F-BAR domain: a dimerizing and membrane recruitment module that effects membrane curvature. Structure (London, England : 1993). 15: 839-52. PMID 17540576 DOI: 10.1016/J.Str.2007.05.002 |
0.45 |
|
| 2007 |
Jayasinghe SA, Langen R. Membrane interaction of islet amyloid polypeptide. Biochimica Et Biophysica Acta. 1768: 2002-9. PMID 17349968 DOI: 10.1016/J.Bbamem.2007.01.022 |
0.452 |
|
| 2007 |
Fischer T, Lu L, Haigler HT, Langen R. Annexin B12 is a sensor of membrane curvature and undergoes major curvature-dependent structural changes. The Journal of Biological Chemistry. 282: 9996-10004. PMID 17267400 DOI: 10.1074/Jbc.M611180200 |
0.481 |
|
| 2006 |
Margittai M, Langen R. Spin labeling analysis of amyloids and other protein aggregates. Methods in Enzymology. 413: 122-39. PMID 17046394 DOI: 10.1016/S0076-6879(06)13007-4 |
0.425 |
|
| 2006 |
Margittai M, Langen R. Side chain-dependent stacking modulates tau filament structure. The Journal of Biological Chemistry. 281: 37820-7. PMID 17023423 DOI: 10.1074/Jbc.M605336200 |
0.374 |
|
| 2006 |
Meier JJ, Kayed R, Lin CY, Gurlo T, Haataja L, Jayasinghe S, Langen R, Glabe CG, Butler PC. Inhibition of human IAPP fibril formation does not prevent beta-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP. American Journal of Physiology. Endocrinology and Metabolism. 291: E1317-24. PMID 16849627 DOI: 10.1152/Ajpendo.00082.2006 |
0.323 |
|
| 2006 |
Gallop JL, Jao CC, Kent HM, Butler PJ, Evans PR, Langen R, McMahon HT. Mechanism of endophilin N-BAR domain-mediated membrane curvature. The Embo Journal. 25: 2898-910. PMID 16763559 DOI: 10.1038/Sj.Emboj.7601174 |
0.735 |
|
| 2006 |
Luibl V, Isas JM, Kayed R, Glabe CG, Langen R, Chen J. Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers. The Journal of Clinical Investigation. 116: 378-85. PMID 16453022 DOI: 10.1172/Jci25843 |
0.349 |
|
| 2006 |
Hegde BG, Isas JM, Zampighi G, Haigler HT, Langen R. A novel calcium-independent peripheral membrane-bound form of annexin B12. Biochemistry. 45: 934-42. PMID 16411769 DOI: 10.1021/Bi052143+ |
0.411 |
|
| 2006 |
Bedrood S, Jayasinghe SA, Langen R. 61 IDENTIFYING STRUCTURAL FEATURES OF ISLET AMYLOID POLYPEPTIDE USING SITE-DIRECTED SPIN LABELING. Journal of Investigative Medicine. 54: S90.2-S90. DOI: 10.2310/6650.2005.X0004.60 |
0.779 |
|
| 2005 |
Isas JM, Kim YE, Jao CC, Hegde PB, Haigler HT, Langen R. Calcium- and membrane-induced changes in the structure and dynamics of three helical hairpins in annexin B12. Biochemistry. 44: 16435-44. PMID 16342936 DOI: 10.1021/Bi051751M |
0.773 |
|
| 2005 |
Shi GW, Chen J, Concepcion F, Motamedchaboki K, Marjoram P, Langen R, Chen J. Light causes phosphorylation of nonactivated visual pigments in intact mouse rod photoreceptor cells. The Journal of Biological Chemistry. 280: 41184-91. PMID 16219764 DOI: 10.1074/Jbc.M506935200 |
0.487 |
|
| 2005 |
Jayasinghe SA, Langen R. Lipid membranes modulate the structure of islet amyloid polypeptide. Biochemistry. 44: 12113-9. PMID 16142909 DOI: 10.1021/Bi050840W |
0.482 |
|
| 2005 |
Kim YE, Isas JM, Haigler HT, Langen R. A helical hairpin region of soluble annexin B12 refolds and forms a continuous transmembrane helix at mildly acidic pH. The Journal of Biological Chemistry. 280: 32398-404. PMID 15975928 DOI: 10.1074/Jbc.M505017200 |
0.603 |
|
| 2005 |
Raghavan SC, Chastain P, Lee JS, Hegde BG, Houston S, Langen R, Hsieh CL, Haworth IS, Lieber MR. Evidence for a triplex DNA conformation at the bcl-2 major breakpoint region of the t(14;18) translocation. The Journal of Biological Chemistry. 280: 22749-60. PMID 15840562 DOI: 10.1074/Jbc.M502952200 |
0.304 |
|
| 2005 |
Patel DR, Isas JM, Ladokhin AS, Jao CC, Kim YE, Kirsch T, Langen R, Haigler HT. The conserved core domains of annexins A1, A2, A5, and B12 can be divided into two groups with different Ca2+-dependent membrane-binding properties. Biochemistry. 44: 2833-44. PMID 15723527 DOI: 10.1021/Bi047642+ |
0.746 |
|
| 2004 |
Lee JC, Langen R, Hummel PA, Gray HB, Winkler JR. Alpha-synuclein structures from fluorescence energy-transfer kinetics: implications for the role of the protein in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 101: 16466-71. PMID 15536128 DOI: 10.1073/Pnas.0407307101 |
0.377 |
|
| 2004 |
Jayasinghe SA, Langen R. Identifying structural features of fibrillar islet amyloid polypeptide using site-directed spin labeling. The Journal of Biological Chemistry. 279: 48420-5. PMID 15358791 DOI: 10.1074/Jbc.M406853200 |
0.372 |
|
| 2004 |
Margittai M, Langen R. Template-assisted filament growth by parallel stacking of tau. Proceedings of the National Academy of Sciences of the United States of America. 101: 10278-83. PMID 15240881 DOI: 10.1073/Pnas.0401911101 |
0.364 |
|
| 2004 |
Jao CC, Der-Sarkissian A, Chen J, Langen R. Structure of membrane-bound alpha-synuclein studied by site-directed spin labeling. Proceedings of the National Academy of Sciences of the United States of America. 101: 8331-6. PMID 15155902 DOI: 10.1073/Pnas.0400553101 |
0.756 |
|
| 2004 |
Isas JM, Langen R, Hubbell WL, Haigler HT. Structure and dynamics of a helical hairpin that mediates calcium-dependent membrane binding of annexin B12. The Journal of Biological Chemistry. 279: 32492-8. PMID 15143059 DOI: 10.1074/Jbc.M402568200 |
0.466 |
|
| 2003 |
Der-Sarkissian A, Jao CC, Chen J, Langen R. Structural organization of alpha-synuclein fibrils studied by site-directed spin labeling. The Journal of Biological Chemistry. 278: 37530-5. PMID 12815044 DOI: 10.1074/Jbc.M305266200 |
0.725 |
|
| 2003 |
Isas JM, Patel DR, Jao C, Jayasinghe S, Cartailler JP, Haigler HT, Langen R. Global structural changes in annexin 12. The roles of phospholipid, Ca2+, and pH. The Journal of Biological Chemistry. 278: 30227-34. PMID 12756261 DOI: 10.1074/Jbc.M301228200 |
0.736 |
|
| 2003 |
Margittai M, Fasshauer D, Jahn R, Langen R. The Habc domain and the SNARE core complex are connected by a highly flexible linker. Biochemistry. 42: 4009-14. PMID 12680753 DOI: 10.1021/Bi027437Z |
0.438 |
|
| 2002 |
Török M, Milton S, Kayed R, Wu P, McIntire T, Glabe CG, Langen R. Structural and dynamic features of Alzheimer's Abeta peptide in amyloid fibrils studied by site-directed spin labeling. The Journal of Biological Chemistry. 277: 40810-5. PMID 12181315 DOI: 10.1074/Jbc.M205659200 |
0.373 |
|
| 2002 |
Isas JM, Langen R, Haigler HT, Hubbell WL. Structure and dynamics of a helical hairpin and loop region in annexin 12: a site-directed spin labeling study. Biochemistry. 41: 1464-73. PMID 11814339 DOI: 10.1021/Bi011856Z |
0.35 |
|
| 2002 |
Pabst S, Margittai M, Vainius D, Langen R, Jahn R, Fasshauer D. Rapid and selective binding to the synaptic SNARE complex suggests a modulatory role of complexins in neuroexocytosis. The Journal of Biological Chemistry. 277: 7838-48. PMID 11751907 DOI: 10.1074/Jbc.M109507200 |
0.413 |
|
| 2001 |
Patel DR, Jao CC, Mailliard WS, Isas JM, Langen R, Haigler HT. Calcium-dependent binding of annexin 12 to phospholipid bilayers: stoichiometry and implications. Biochemistry. 40: 7054-60. PMID 11401549 DOI: 10.1021/bi010345+ |
0.672 |
|
| 2001 |
Margittai M, Fasshauer D, Pabst S, Jahn R, Langen R. Homo- and heterooligomeric SNARE complexes studied by site-directed spin labeling. The Journal of Biological Chemistry. 276: 13169-77. PMID 11278719 DOI: 10.1074/Jbc.M010653200 |
0.423 |
|
| 2000 |
Langen R, Oh KJ, Cascio D, Hubbell WL. Crystal structures of spin labeled T4 lysozyme mutants: implications for the interpretation of EPR spectra in terms of structure. Biochemistry. 39: 8396-405. PMID 10913245 DOI: 10.1021/Bi000604F |
0.322 |
|
| 2000 |
Isas JM, Cartailler JP, Sokolov Y, Patel DR, Langen R, Luecke H, Hall JE, Haigler HT. Annexins V and XII insert into bilayers at mildly acidic pH and form ion channels. Biochemistry. 39: 3015-22. PMID 10715122 DOI: 10.1021/Bi9922401 |
0.337 |
|
| 1998 |
Langen R, Isas JM, Hubbell WL, Haigler HT. A transmembrane form of annexin XII detected by site-directed spin labeling. Proceedings of the National Academy of Sciences of the United States of America. 95: 14060-5. PMID 9826653 DOI: 10.1073/Pnas.95.24.14060 |
0.469 |
|
| 1998 |
Hubbell WL, Gross A, Langen R, Lietzow MA. Recent advances in site-directed spin labeling of proteins. Current Opinion in Structural Biology. 8: 649-56. PMID 9818271 DOI: 10.1016/S0959-440X(98)80158-9 |
0.426 |
|
| 1998 |
Langen R, Isas JM, Luecke H, Haigler HT, Hubbell WL. Membrane-mediated assembly of annexins studied by site-directed spin labeling. The Journal of Biological Chemistry. 273: 22453-7. PMID 9712869 DOI: 10.1074/jbc.273.35.22453 |
0.366 |
|
| 1996 |
Muegge I, Schweins T, Langen R, Warshel A. Electrostatic control of GTP and GDP binding in the oncoprotein p21ras. Structure (London, England : 1993). 4: 475-89. PMID 8740369 DOI: 10.1016/S0969-2126(96)00052-4 |
0.339 |
|
| 1992 |
Langen R, Brayer GD, Berghuis AM, McLendon G, Sherman F, Warshel A. Effect of the Asn52----Ile mutation on the redox potential of yeast cytochrome c. Theory and experiment. Journal of Molecular Biology. 224: 589-600. PMID 1314900 DOI: 10.1016/0022-2836(92)90546-V |
0.307 |
|
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