Edward M. De Robertis - Publications

Affiliations: 
University of California, Los Angeles, Los Angeles, CA 

160 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Azbazdar Y, De Robertis EM. Molecular analysis of a self-organizing signaling pathway for axial patterning from egg to tailbud. Proceedings of the National Academy of Sciences of the United States of America. 121: e2408346121. PMID 38968117 DOI: 10.1073/pnas.2408346121  0.386
2023 Azbazdar Y, Pera EM, De Robertis EM. Head organizer: Cerberus and IGF cooperate in brain induction in Xenopus embryos. Cells & Development. 203897. PMID 38109998 DOI: 10.1016/j.cdev.2023.203897  0.764
2023 Azbazdar Y, De Robertis EM. The early dorsal signal in vertebrate embryos requires endolysosomal membrane trafficking. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. e2300179. PMID 37983969 DOI: 10.1002/bies.202300179  0.336
2023 Azbazdar Y, Tejeda-Munoz N, Monka JC, Dayrit A, Binder G, Ozhan G, De Robertis EM. Addition of exogenous diacylglycerol enhances Wnt/β-catenin signaling through stimulation of macropinocytosis. Iscience. 26: 108075. PMID 37860772 DOI: 10.1016/j.isci.2023.108075  0.355
2023 Tejeda-Muñoz N, Azbazdar Y, Monka J, Binder G, Dayrit A, Ayala R, O'Brien N, De Robertis EM. The PMA Phorbol Ester Tumor Promoter Increases Canonical Wnt Signaling Via Macropinocytosis. Biorxiv : the Preprint Server For Biology. PMID 37333286 DOI: 10.1101/2023.06.02.543509  0.323
2022 Tejeda-Muñoz N, De Robertis EM. Lysosomes are required for early dorsal signaling in the embryo. Proceedings of the National Academy of Sciences of the United States of America. 119: e2201008119. PMID 35446621 DOI: 10.1073/pnas.2201008119  0.384
2022 Tejeda-Muñoz N, Morselli M, Moriyama Y, Sheladiya P, Pellegrini M, De Robertis EM. Canonical Wnt signaling induces focal adhesion and Integrin beta-1 endocytosis. Iscience. 25: 104123. PMID 35402867 DOI: 10.1016/j.isci.2022.104123  0.365
2022 Tejeda-Muñoz N, De Robertis EM. Wnt, GSK3, and Macropinocytosis. Sub-Cellular Biochemistry. 98: 169-187. PMID 35378708 DOI: 10.1007/978-3-030-94004-1_9  0.363
2021 Albrecht LV, Tejeda-Muñoz N, De Robertis EM. Cell Biology of Canonical Wnt Signaling. Annual Review of Cell and Developmental Biology. PMID 34196570 DOI: 10.1146/annurev-cellbio-120319-023657  0.365
2021 Zhang F, Zhu X, Wang P, He Q, Huang H, Zheng T, Li Y, Jia H, Xu L, Zhao H, Colozza G, Tao Q, De Robertis EM, Ding Y. The cytokine FAM3B/PANDER is an FGFR ligand that promotes posterior development in . Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33975953 DOI: 10.1073/pnas.2100342118  0.448
2021 De Robertis EM, Gurdon JB. A Brief History of in Biology. Cold Spring Harbor Protocols. PMID 33785561 DOI: 10.1101/pdb.top107615  0.532
2020 Colozza G, Jami-Alahmadi Y, Dsouza A, Tejeda-Muñoz N, Albrecht LV, Sosa EA, Wohlschlegel JA, De Robertis EM. Wnt-inducible Lrp6-APEX2 interacting proteins identify ESCRT machinery and Trk-fused gene as components of the Wnt signaling pathway. Scientific Reports. 10: 21555. PMID 33299006 DOI: 10.1038/s41598-020-78019-5  0.385
2020 Colozza G, De Robertis EM. Dact-4 is a Xenopus laevis Spemann organizer gene related to the Dapper/Frodo antagonist of β-catenin family of proteins. Gene Expression Patterns : Gep. 38: 119153. PMID 33186756 DOI: 10.1016/j.gep.2020.119153  0.328
2020 Albrecht LV, Tejeda-Muñoz N, Bui MH, Cicchetto AC, Di Biagio D, Colozza G, Schmid E, Piccolo S, Christofk HR, De Robertis EM. GSK3 Inhibits Macropinocytosis and Lysosomal Activity through the Wnt Destruction Complex Machinery. Cell Reports. 32: 107973. PMID 32726636 DOI: 10.1016/J.Celrep.2020.107973  0.601
2019 Sosa EA, Moriyama Y, Ding Y, Tejeda-Muñoz N, Colozza G, De Robertis EM. Transcriptome analysis of regeneration during Xenopus laevis experimental twinning. The International Journal of Developmental Biology. 63: 301-309. PMID 31250914 DOI: 10.1387/ijdb.190006ed  0.323
2019 Tejeda-Muñoz N, Albrecht LV, Bui MH, De Robertis EM. Wnt canonical pathway activates macropinocytosis and lysosomal degradation of extracellular proteins. Proceedings of the National Academy of Sciences of the United States of America. PMID 31061124 DOI: 10.1073/pnas.1903506116  0.366
2018 Ding Y, Colozza G, Sosa EA, Moriyama Y, Rundle S, Salwinski L, De Robertis EM. Bighead is a Wnt antagonist secreted by the Spemann organizer that promotes Lrp6 endocytosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 30209221 DOI: 10.1073/pnas.1812117115  0.451
2018 Albrecht LV, Ploper D, Tejeda-Muñoz N, De Robertis EM. Arginine methylation is required for canonical Wnt signaling and endolysosomal trafficking. Proceedings of the National Academy of Sciences of the United States of America. PMID 29773710 DOI: 10.1073/pnas.1804091115  0.341
2017 Kirsch N, Chang LS, Koch S, Glinka A, Dolde C, Colozza G, Benitez MDJ, De Robertis EM, Niehrs C. Angiopoietin-like 4 Is a Wnt Signaling Antagonist that Promotes LRP6 Turnover. Developmental Cell. 43: 71-82.e6. PMID 29017031 DOI: 10.1016/J.Devcel.2017.09.011  0.616
2017 De Robertis EM, Moriyama Y, Colozza G. Generation of animal form by the Chordin/Tolloid/BMP gradient: 100 years after D'Arcy Thompson. Development, Growth & Differentiation. PMID 28815565 DOI: 10.1111/dgd.12388  0.327
2017 Ding Y, Ploper D, Sosa EA, Colozza G, Moriyama Y, Benitez MD, Zhang K, Merkurjev D, De Robertis EM. Spemann organizer transcriptome induction by early beta-catenin, Wnt, Nodal, and Siamois signals in Xenopus laevis. Proceedings of the National Academy of Sciences of the United States of America. PMID 28348214 DOI: 10.1073/pnas.1700766114  0.339
2016 Ding Y, Colozza G, Zhang K, Moriyama Y, Ploper D, Sosa EA, Benitez MD, De Robertis EM. Genome-wide analysis of dorsal and ventral transcriptomes of the Xenopus laevis gastrula. Developmental Biology. PMID 27016259 DOI: 10.1016/j.ydbio.2016.02.032  0.305
2015 De Robertis EM, Ploper D. Sperm Motility Requires Wnt/GSK3 Stabilization of Proteins. Developmental Cell. 35: 401-402. PMID 26609954 DOI: 10.1016/j.devcel.2015.11.009  0.349
2015 Blum M, De Robertis EM, Wallingford JB, Niehrs C. Morpholinos: Antisense and Sensibility. Developmental Cell. 35: 145-9. PMID 26506304 DOI: 10.1016/J.Devcel.2015.09.017  0.658
2015 Bier E, De Robertis EM. BMP gradients: A paradigm for morphogen-mediated developmental patterning Science. 348. PMID 26113727 DOI: 10.1126/science.aaa5838  0.364
2015 Kim H, Vick P, Hedtke J, Ploper D, De Robertis EM. Wnt Signaling Translocates Lys48-Linked Polyubiquitinated Proteins to the Lysosomal Pathway. Cell Reports. 11: 1151-9. PMID 26004177 DOI: 10.1016/j.celrep.2015.04.048  0.324
2015 Ploper D, De Robertis EM. The MITF family of transcription factors: Role in endolysosomal biogenesis, Wnt signaling, and oncogenesis. Pharmacological Research. 99: 36-43. PMID 26003288 DOI: 10.1016/j.phrs.2015.04.006  0.352
2015 Ploper D, Taelman VF, Robert L, Perez BS, Titz B, Chen HW, Graeber TG, von Euw E, Ribas A, De Robertis EM. MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells. Proceedings of the National Academy of Sciences of the United States of America. 112: E420-9. PMID 25605940 DOI: 10.1073/pnas.1424576112  0.408
2015 Kim H, Vick P, Hedtke J, Ploper D, De Robertis EM. Wnt Signaling Translocates Lys48-Linked Polyubiquitinated Proteins to the Lysosomal Pathway Cell Reports. 11: 1151-1159. DOI: 10.1016/j.celrep.2015.04.048  0.336
2014 Demagny H, Araki T, De Robertis EM. The tumor suppressor Smad4/DPC4 is regulated by phosphorylations that integrate FGF, Wnt, and TGF-β signaling. Cell Reports. 9: 688-700. PMID 25373906 DOI: 10.1016/j.celrep.2014.09.020  0.324
2014 De Robertis EM, Niehrs C. Herbert Steinbeisser: a life with the Xenopus embryo. The International Journal of Developmental Biology. 58: 299-302. PMID 25354448 DOI: 10.1387/Ijdb.140117Ed  0.446
2014 Colozza G, De Robertis EM. Maternal syntabulin is required for dorsal axis formation and is a germ plasm component in Xenopus. Differentiation; Research in Biological Diversity. 88: 17-26. PMID 24798204 DOI: 10.1016/j.diff.2014.03.002  0.353
2013 Plouhinec JL, Zakin L, Moriyama Y, De Robertis EM. Chordin forms a self-organizing morphogen gradient in the extracellular space between ectoderm and mesoderm in the Xenopus embryo. Proceedings of the National Academy of Sciences of the United States of America. 110: 20372-9. PMID 24284174 DOI: 10.1073/pnas.1319745110  0.382
2012 Dobrowolski R, Vick P, Ploper D, Gumper I, Snitkin H, Sabatini DD, De Robertis EM. Presenilin deficiency or lysosomal inhibition enhances Wnt signaling through relocalization of GSK3 to the late-endosomal compartment. Cell Reports. 2: 1316-28. PMID 23122960 DOI: 10.1016/J.Celrep.2012.09.026  0.38
2012 Dobrowolski R, De Robertis EM. Endocytic control of growth factor signalling: multivesicular bodies as signalling organelles. Nature Reviews. Molecular Cell Biology. 13: 53-60. PMID 22108513 DOI: 10.1038/nrm3244  0.33
2011 Eivers E, Demagny H, Choi RH, De Robertis EM. Phosphorylation of Mad controls competition between wingless and BMP signaling. Science Signaling. 4: ra68. PMID 21990430 DOI: 10.1126/scisignal.2002034  0.394
2011 Vorwald-Denholtz PP, De Robertis EM. Temporal pattern of the posterior expression of Wingless in Drosophila blastoderm. Gene Expression Patterns : Gep. 11: 456-63. PMID 21821151 DOI: 10.1016/j.gep.2011.07.004  0.313
2011 Ploper D, Lee HX, De Robertis EM. Dorsal-ventral patterning: Crescent is a dorsally secreted Frizzled-related protein that competitively inhibits Tolloid proteases. Developmental Biology. 352: 317-28. PMID 21295563 DOI: 10.1016/j.ydbio.2011.01.029  0.624
2011 De Robertis EM, VanHook AM. Science Signaling Podcast: 11 October 2011 Science Signaling. 4: pc21-pc21. DOI: 10.1126/Scisignal.2002559  0.311
2010 Taelman VF, Dobrowolski R, Plouhinec JL, Fuentealba LC, Vorwald PP, Gumper I, Sabatini DD, De Robertis EM. Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes. Cell. 143: 1136-48. PMID 21183076 DOI: 10.1016/J.Cell.2010.11.034  0.812
2010 Zakin L, Chang EY, Plouhinec JL, De Robertis EM. Crossveinless-2 is required for the relocalization of Chordin protein within the vertebral field in mouse embryos. Developmental Biology. 347: 204-15. PMID 20807528 DOI: 10.1016/j.ydbio.2010.08.025  0.335
2010 De Robertis EM. Wnt signaling in axial patterning and regeneration: lessons from planaria. Science Signaling. 3: pe21. PMID 20571126 DOI: 10.1126/scisignal.3127pe21  0.383
2010 Sander V, Eivers E, Choi RH, De Robertis EM. Drosophila Smad2 opposes Mad signaling during wing vein development. Plos One. 5: e10383. PMID 20442782 DOI: 10.1371/journal.pone.0010383  0.423
2010 Tran U, Zakin L, Schweickert A, Agrawal R, Döger R, Blum M, De Robertis EM, Wessely O. The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity. Development (Cambridge, England). 137: 1107-16. PMID 20215348 DOI: 10.1242/Dev.046045  0.592
2010 Fuentealba LC, Eivers E, Lee HX, De Robertis EM. Integration of BMP, RTK, and wnt signaling through smad1 phosphorylations Handbook of Cell Signaling, 2/E. 2: 1989-1994. DOI: 10.1016/B978-0-12-374145-5.00243-6  0.785
2009 Plouhinec JL, De Robertis EM. Systems biology of the self-regulating morphogenetic gradient of the Xenopus gastrula. Cold Spring Harbor Perspectives in Biology. 1: a001701. PMID 20066084 DOI: 10.1101/cshperspect.a001701  0.395
2009 Eivers E, Demagny H, De Robertis EM. Integration of BMP and Wnt signaling via vertebrate Smad1/5/8 and Drosophila Mad. Cytokine & Growth Factor Reviews. 20: 357-65. PMID 19896409 DOI: 10.1016/j.cytogfr.2009.10.017  0.376
2009 Lee HX, Mendes FA, Plouhinec JL, De Robertis EM. Enzymatic regulation of pattern: BMP4 binds CUB domains of Tolloids and inhibits proteinase activity. Genes & Development. 23: 2551-62. PMID 19884260 DOI: 10.1101/gad.1839309  0.591
2009 De Robertis EM. Spemann's organizer and the self-regulation of embryonic fields. Mechanisms of Development. 126: 925-41. PMID 19733655 DOI: 10.1016/j.mod.2009.08.004  0.407
2009 Eivers E, Fuentealba LC, Sander V, Clemens JC, Hartnett L, De Robertis EM. Mad is required for wingless signaling in wing development and segment patterning in Drosophila. Plos One. 4: e6543. PMID 19657393 DOI: 10.1371/Journal.Pone.0006543  0.778
2008 Zakin L, Metzinger CA, Chang EY, Coffinier C, De Robertis EM. Development of the vertebral morphogenetic field in the mouse: interactions between Crossveinless-2 and Twisted Gastrulation. Developmental Biology. 323: 6-18. PMID 18789316 DOI: 10.1016/j.ydbio.2008.08.019  0.33
2008 Ambrosio AL, Taelman VF, Lee HX, Metzinger CA, Coffinier C, De Robertis EM. Crossveinless-2 Is a BMP feedback inhibitor that binds Chordin/BMP to regulate Xenopus embryonic patterning. Developmental Cell. 15: 248-60. PMID 18694564 DOI: 10.1016/j.devcel.2008.06.013  0.612
2008 Eivers E, Fuentealba LC, De Robertis EM. Integrating positional information at the level of Smad1/5/8. Current Opinion in Genetics & Development. 18: 304-10. PMID 18590818 DOI: 10.1016/J.Gde.2008.06.001  0.781
2008 Fuentealba LC, Eivers E, Geissert D, Taelman V, De Robertis EM. Asymmetric mitosis: Unequal segregation of proteins destined for degradation. Proceedings of the National Academy of Sciences of the United States of America. 105: 7732-7. PMID 18511557 DOI: 10.1073/Pnas.0803027105  0.757
2008 Ishibashi H, Matsumura N, Hanafusa H, Matsumoto K, De Robertis EM, Kuroda H. Expression of Siamois and Twin in the blastula Chordin/Noggin signaling center is required for brain formation in Xenopus laevis embryos. Mechanisms of Development. 125: 58-66. PMID 18036787 DOI: 10.1016/J.Mod.2007.10.005  0.728
2007 Fuentealba LC, Eivers E, Ikeda A, Hurtado C, Kuroda H, Pera EM, De Robertis EM. Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal. Cell. 131: 980-93. PMID 18045539 DOI: 10.1016/J.Cell.2007.09.027  0.814
2007 Sander V, Reversade B, De Robertis EM. The opposing homeobox genes Goosecoid and Vent1/2 self-regulate Xenopus patterning. The Embo Journal. 26: 2955-65. PMID 17525737 DOI: 10.1038/Sj.Emboj.7601705  0.611
2006 De Robertis EM. Spemann's organizer and self-regulation in amphibian embryos. Nature Reviews. Molecular Cell Biology. 7: 296-302. PMID 16482093 DOI: 10.1038/nrm1855  0.373
2006 Lee HX, Ambrosio AL, Reversade B, De Robertis EM. Embryonic dorsal-ventral signaling: secreted frizzled-related proteins as inhibitors of tolloid proteinases. Cell. 124: 147-59. PMID 16413488 DOI: 10.1016/J.Cell.2005.12.018  0.71
2005 Reversade B, De Robertis EM. Regulation of ADMP and BMP2/4/7 at opposite embryonic poles generates a self-regulating morphogenetic field. Cell. 123: 1147-60. PMID 16360041 DOI: 10.1016/J.Cell.2005.08.047  0.644
2005 Pera EM, Hou S, Strate I, Wessely O, De Robertis EM. Exploration of the extracellular space by a large-scale secretion screen in the early Xenopus embryo. The International Journal of Developmental Biology. 49: 781-96. PMID 16172975 DOI: 10.1387/ijdb.052003ep  0.74
2005 Reversade B, Kuroda H, Lee H, Mays A, De Robertis EM. Depletion of Bmp2, Bmp4, Bmp7 and Spemann organizer signals induces massive brain formation in Xenopus embryos. Development (Cambridge, England). 132: 3381-92. PMID 15975940 DOI: 10.1242/Dev.01901  0.819
2005 Wessely O, Kim JI, Tran U, Fuentealba L, De Robertis EM. xBtg-x regulates Wnt/beta-Catenin signaling during early Xenopus development. Developmental Biology. 283: 17-28. PMID 15975429 DOI: 10.1016/J.Ydbio.2005.03.033  0.776
2005 Kuroda H, Fuentealba L, Ikeda A, Reversade B, De Robertis EM. Default neural induction: neuralization of dissociated Xenopus cells is mediated by Ras/MAPK activation. Genes & Development. 19: 1022-7. PMID 15879552 DOI: 10.1101/Gad.1306605  0.797
2005 Zakin L, Reversade B, Kuroda H, Lyons KM, De Robertis EM. Sirenomelia in Bmp7 and Tsg compound mutant mice: requirement for Bmp signaling in the development of ventral posterior mesoderm. Development (Cambridge, England). 132: 2489-99. PMID 15843411 DOI: 10.1242/Dev.01822  0.777
2004 De Robertis EM, Kuroda H. Dorsal-ventral patterning and neural induction in Xenopus embryos. Annual Review of Cell and Developmental Biology. 20: 285-308. PMID 15473842 DOI: 10.1146/Annurev.Cellbio.20.011403.154124  0.749
2004 Kuroda H, Wessely O, De Robertis EM. Neural induction in Xenopus: requirement for ectodermal and endomesodermal signals via Chordin, Noggin, beta-Catenin, and Cerberus. Plos Biology. 2: E92. PMID 15138495 DOI: 10.1371/Journal.Pbio.0020092  0.732
2004 Wessely O, Kim JI, Geissert D, Tran U, De Robertis EM. Analysis of Spemann organizer formation in Xenopus embryos by cDNA macroarrays. Developmental Biology. 269: 552-66. PMID 15110719 DOI: 10.1016/j.ydbio.2004.01.018  0.425
2004 Oelgeschläger M, Tran U, Grubisic K, De Robertis EM. Identification of a second Xenopus twisted gastrulation gene. The International Journal of Developmental Biology. 48: 57-61. PMID 15005575 DOI: 10.1387/ijdb.15005575  0.376
2004 Zakin L, De Robertis EM. Inactivation of mouse Twisted gastrulation reveals its role in promoting Bmp4 activity during forebrain development. Development (Cambridge, England). 131: 413-24. PMID 14681194 DOI: 10.1242/dev.00946  0.382
2003 Pera EM, Ikeda A, Eivers E, De Robertis EM. Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction. Genes & Development. 17: 3023-8. PMID 14701872 DOI: 10.1101/gad.1153603  0.768
2003 Oelgeschläger M, Reversade B, Larraín J, Little S, Mullins MC, De Robertis EM. The pro-BMP activity of Twisted gastrulation is independent of BMP binding. Development (Cambridge, England). 130: 4047-56. PMID 12874126 DOI: 10.1242/Dev.00633  0.624
2003 Bachiller D, Klingensmith J, Shneyder N, Tran U, Anderson R, Rossant J, De Robertis EM. The role of chordin/Bmp signals in mammalian pharyngeal development and DiGeorge syndrome. Development (Cambridge, England). 130: 3567-78. PMID 12810603 DOI: 10.1242/Dev.00581  0.349
2003 Pera EM, Martinez SL, Flanagan JJ, Brechner M, Wessely O, De Robertis EM. Darmin is a novel secreted protein expressed during endoderm development in Xenopus. Gene Expression Patterns : Gep. 3: 147-52. PMID 12711541 DOI: 10.1016/S1567-133X(03)00011-5  0.748
2003 Oelgeschläger M, Kuroda H, Reversade B, De Robertis EM. Chordin is required for the Spemann organizer transplantation phenomenon in Xenopus embryos. Developmental Cell. 4: 219-30. PMID 12586065 DOI: 10.1016/S1534-5807(02)00404-5  0.742
2002 Coffinier C, Ketpura N, Tran U, Geissert D, De Robertis EM. Mouse Crossveinless-2 is the vertebrate homolog of a Drosophila extracellular regulator of BMP signaling. Mechanisms of Development. 119: S179-84. PMID 14516682 DOI: 10.1016/S0925-4773(03)00113-8  0.823
2002 Coffinier C, Ketpura N, Tran U, Geissert D, De Robertis EM. Mouse Crossveinless-2 is the vertebrate homolog of a Drosophila extracellular regulator of BMP signaling. Gene Expression Patterns : Gep. 2: 189-94. PMID 12617799 DOI: 10.1016/S0925-4773(02)00420-3  0.823
2002 Abreu JG, Ketpura NI, Reversade B, De Robertis EM. Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta. Nature Cell Biology. 4: 599-604. PMID 12134160 DOI: 10.1038/Ncb826  0.779
2002 Pera EM, Kim JI, Martinez SL, Brechner M, Li SY, Wessely O, De Robertis EM. Isthmin is a novel secreted protein expressed as part of the Fgf-8 synexpression group in the Xenopus midbrain-hindbrain organizer. Mechanisms of Development. 116: 169-72. PMID 12128218 DOI: 10.1016/S0925-4773(02)00123-5  0.764
2002 Garcia Abreu J, Coffinier C, Larraín J, Oelgeschläger M, De Robertis EM. Chordin-like CR domains and the regulation of evolutionarily conserved extracellular signaling systems. Gene. 287: 39-47. PMID 11992721 DOI: 10.1016/S0378-1119(01)00827-7  0.33
2001 Larraín J, Oelgeschläger M, Ketpura NI, Reversade B, Zakin L, De Robertis EM. Proteolytic cleavage of Chordin as a switch for the dual activities of Twisted gastrulation in BMP signaling. Development (Cambridge, England). 128: 4439-47. PMID 11714670  0.826
2001 Pera EM, Wessely O, Li SY, De Robertis EM. Neural and head induction by insulin-like growth factor signals. Developmental Cell. 1: 655-65. PMID 11709186 DOI: 10.1016/S1534-5807(01)00069-7  0.759
2001 Wessely O, Agius E, Oelgeschläger M, Pera EM, De Robertis EM. Neural induction in the absence of mesoderm: beta-catenin-dependent expression of secreted BMP antagonists at the blastula stage in Xenopus. Developmental Biology. 234: 161-73. PMID 11356027 DOI: 10.1006/dbio.2001.0258  0.77
2001 De Robertis EM, Wessely O, Oelgeschläger M, Brizuela B, Pera E, Larraín J, Abreu J, Bachiller D. Molecular mechanisms of cell-cell signaling by the Spemann-Mangold organizer. The International Journal of Developmental Biology. 45: 189-97. PMID 11291846  0.345
2001 Wessely O, Tran U, Zakin L, De Robertis EM. Identification and expression of the mammalian homologue of Bicaudal-C. Mechanisms of Development. 101: 267-70. PMID 11231089 DOI: 10.1016/S0925-4773(00)00568-2  0.301
2001 Coffinier C, Tran U, Larraín J, De Robertis EM. Neuralin-1 is a novel Chordin-related molecule expressed in the mouse neural plate. Mechanisms of Development. 100: 119-22. PMID 11118896 DOI: 10.1016/S0925-4773(00)00507-4  0.345
2000 De Robertis EM, Larraín J, Oelgeschläger M, Wessely O. The establishment of Spemann's organizer and patterning of the vertebrate embryo. Nature Reviews. Genetics. 1: 171-81. PMID 11252746 DOI: 10.1038/35042039  0.352
2000 Pera EM, De Robertis EM. A direct screen for secreted proteins in Xenopus embryos identifies distinct activities for the Wnt antagonists Crescent and Frzb-1. Mechanisms of Development. 96: 183-95. PMID 10960783 DOI: 10.1016/S0925-4773(00)00394-4  0.774
2000 Oelgeschläger M, Larraín J, Geissert D, De Robertis EM. The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling. Nature. 405: 757-63. PMID 10866189 DOI: 10.1038/35015500  0.438
2000 Belo JA, Bachiller D, Agius E, Kemp C, Borges AC, Marques S, Piccolo S, De Robertis EM. Cerberus-like is a secreted BMP and nodal antagonist not essential for mouse development. Genesis (New York, N.Y. : 2000). 26: 265-70. PMID 10748465 DOI: 10.1002/(Sici)1526-968X(200004)26:4<265::Aid-Gene80>3.0.Co;2-4  0.599
2000 Agius E, Oelgeschläger M, Wessely O, Kemp C, De Robertis EM. Endodermal Nodal-related signals and mesoderm induction in Xenopus. Development (Cambridge, England). 127: 1173-83. PMID 10683171  0.389
1999 Konishi Y, Tominaga M, Watanabe Y, Imamura F, Goldfarb A, Maki R, Blum M, De Robertis EM, Tominaga A. GOOSECOID inhibits erythrocyte differentiation by competing with Rb for PU.1 binding in murine cells. Oncogene. 18: 6795-805. PMID 10597288 DOI: 10.1038/Sj.Onc.1203118  0.62
1999 Duprez D, Leyns L, Bonnin MA, Lapointe F, Etchevers H, De Robertis EM, Le Douarin N. Expression of Frzb-1 during chick development. Mechanisms of Development. 89: 179-83. PMID 10559495 DOI: 10.1016/S0925-4773(99)00206-3  0.302
1999 Borello U, Coletta M, Tajbakhsh S, Leyns L, De Robertis EM, Buckingham M, Cossu G. Transplacental delivery of the Wnt antagonist Frzb1 inhibits development of caudal paraxial mesoderm and skeletal myogenesis in mouse embryos. Development (Cambridge, England). 126: 4247-55. PMID 10477293  0.386
1999 Piccolo S, Agius E, Leyns L, Bhattacharyya S, Grunz H, Bouwmeester T, De Robertis EM. The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals. Nature. 397: 707-10. PMID 10067895 DOI: 10.1038/17820  0.689
1998 Yamamoto A, Amacher SL, Kim SH, Geissert D, Kimmel CB, De Robertis EM. Zebrafish paraxial protocadherin is a downstream target of spadetail involved in morphogenesis of gastrula mesoderm. Development (Cambridge, England). 125: 3389-97. PMID 9693142  0.307
1998 Blumberg B, Kang H, Bolado J, Chen H, Craig AG, Moreno TA, Umesono K, Perlmann T, De Robertis EM, Evans RM. BXR, an embryonic orphan nuclear receptor activated by a novel class of endogenous benzoate metabolites. Genes & Development. 12: 1269-77. PMID 9573044 DOI: 10.1101/Gad.12.9.1269  0.616
1998 Belo JA, Leyns L, Yamada G, De Robertis EM. The prechordal midline of the chondrocranium is defective in Goosecoid-1 mouse mutants. Mechanisms of Development. 72: 15-25. PMID 9533949 DOI: 10.1016/S0925-4773(97)00204-9  0.323
1998 Pillemer G, Epstein M, Blumberg B, Yisraeli JK, De Robertis EM, Steinbeisser H, Fainsod A. Nested expression and sequential downregulation of the Xenopus caudal genes along the anterior-posterior axis. Mechanisms of Development. 71: 193-6. PMID 9507125 DOI: 10.1016/S0925-4773(97)00193-7  0.674
1997 Heanue TA, Johnson RL, Izpisua-Belmonte JC, Stern CD, De Robertis EM, Tabin CJ. Goosecoid misexpression alters the morphology and Hox gene expression of the developing chick limb bud. Mechanisms of Development. 69: 31-7. PMID 9486529 DOI: 10.1016/S0925-4773(97)00149-4  0.31
1997 Belo JA, Bouwmeester T, Leyns L, Kertesz N, Gallo M, Follettie M, De Robertis EM. Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrula. Mechanisms of Development. 68: 45-57. PMID 9431803 DOI: 10.1016/S0925-4773(97)00125-1  0.314
1997 Piccolo S, Agius E, Lu B, Goodman S, Dale L, De Robertis EM. Cleavage of Chordin by Xolloid metalloprotease suggests a role for proteolytic processing in the regulation of Spemann organizer activity. Cell. 91: 407-16. PMID 9363949 DOI: 10.1016/S0092-8674(00)80424-9  0.631
1997 Pfeffer PL, De Robertis EM, Izpisua-Belmonte JC. Crescent, a novel chick gene encoding a Frizzled-like cysteine-rich domain, is expressed in anterior regions during early embryogenesis. The International Journal of Developmental Biology. 41: 449-58. PMID 9240561  0.313
1997 Leyns L, Bouwmeester T, Kim SH, Piccolo S, De Robertis EM. Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer. Cell. 88: 747-56. PMID 9118218 DOI: 10.1016/S0092-8674(00)81921-2  0.64
1997 Sasai Y, De Robertis EM. Ectodermal patterning in vertebrate embryos. Developmental Biology. 182: 5-20. PMID 9073437 DOI: 10.1006/dbio.1996.8445  0.54
1996 Sasai Y, Lu B, Piccolo S, De Robertis EM. Endoderm induction by the organizer-secreted factors chordin and noggin in Xenopus animal caps. The Embo Journal. 15: 4547-55. PMID 8887546 DOI: 10.1002/J.1460-2075.1996.Tb00832.X  0.705
1996 Bouwmeester T, Kim S, Sasai Y, Lu B, De Robertis EM. Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer. Nature. 382: 595-601. PMID 8757128 DOI: 10.1038/382595a0  0.504
1996 Holley SA, Neul JL, Attisano L, Wrana JL, Sasai Y, O'Connor MB, De Robertis EM, Ferguson EL. The Xenopus dorsalizing factor noggin ventralizes Drosophila embryos by preventing DPP from activating its receptor. Cell. 86: 607-17. PMID 8752215 DOI: 10.1016/S0092-8674(00)80134-8  0.574
1996 Piccolo S, Sasai Y, Lu B, De Robertis EM. Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4. Cell. 86: 589-98. PMID 8752213 DOI: 10.1016/S0092-8674(00)80132-4  0.708
1996 Gont LK, Fainsod A, Kim SH, De Robertis EM. Overexpression of the homeobox gene Xnot-2 leads to notochord formation in Xenopus. Developmental Biology. 174: 174-8. PMID 8626017 DOI: 10.1006/Dbio.1996.0061  0.703
1996 De Robertis EM, Sasai Y. A common plan for dorsoventral patterning in Bilateria. Nature. 380: 37-40. PMID 8598900 DOI: 10.1038/380037a0  0.517
1995 Sasai Y, Lu B, Steinbeisser H, De Robertis EM. Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus. Nature. 376: 333-6. PMID 7630399 DOI: 10.1038/376333a0  0.584
1995 Holley SA, Jackson PD, Sasai Y, Lu B, De Robertis EM, Hoffmann FM, Ferguson EL. A conserved system for dorsal-ventral patterning in insects and vertebrates involving sog and chordin. Nature. 376: 249-53. PMID 7617035 DOI: 10.1038/376249a0  0.554
1995 Steinbeisser H, Fainsod A, Niehrs C, Sasai Y, De Robertis EM. The role of gsc and BMP-4 in dorsal-ventral patterning of the marginal zone in Xenopus: a loss-of-function study using antisense RNA. The Embo Journal. 14: 5230-43. PMID 7489713  0.536
1995 Sasal Y, Lu B, Steinbelsser H, De Robertis EM. Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus. Nature. 378: 419. PMID 7477384 DOI: 10.1038/378419a0  0.347
1995 Sasai Y, Lu B, Steinbeisser H, De Robertis EM. Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus. Nature. 377: 757. PMID 7477270 DOI: 10.1038/377757a0  0.544
1994 Sasai Y, Lu B, Steinbeisser H, Geissert D, Gont LK, De Robertis EM. Xenopus chordin: a novel dorsalizing factor activated by organizer-specific homeobox genes. Cell. 79: 779-90. PMID 8001117 DOI: 10.1016/0092-8674(94)90068-X  0.576
1994 Fainsod A, Steinbeisser H, De Robertis EM. On the function of BMP-4 in patterning the marginal zone of the Xenopus embryo. The Embo Journal. 13: 5015-25. PMID 7957067  0.379
1994 Blum M, De Robertis EM, Kojis T, Heinzmann C, Klisak I, Geissert D, Sparkes RS. Molecular cloning of the human homeobox gene goosecoid (GSC) and mapping of the gene to human chromosome 14q32.1. Genomics. 21: 388-93. PMID 7916327 DOI: 10.1006/Geno.1994.1281  0.585
1994 Niehrs C, Steinbeisser H, De Robertis EM. Mesodermal patterning by a gradient of the vertebrate homeobox gene goosecoid. Science (New York, N.Y.). 263: 817-20. PMID 7905664 DOI: 10.1126/SCIENCE.7905664  0.556
1994 Schulte-Merker S, Hammerschmidt M, Beuchle D, Cho KW, De Robertis EM, Nüsslein-Volhard C. Expression of zebrafish goosecoid and no tail gene products in wild-type and mutant no tail embryos. Development (Cambridge, England). 120: 843-52. PMID 7600961  0.603
1993 Niehrs C, Keller R, Cho KW, De Robertis EM. The homeobox gene goosecoid controls cell migration in Xenopus embryos. Cell. 72: 491-503. PMID 8095000 DOI: 10.1016/0092-8674(93)90069-3  0.572
1993 Bittner D, De Robertis EM, Cho KW. Characterization of the Xenopus Hox 2.4 gene and identification of control elements in its intron. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 196: 11-24. PMID 7916675 DOI: 10.1002/aja.1001960103  0.334
1993 Steinbeisser H, De Robertis EM, Ku M, Kessler DS, Melton DA. Xenopus axis formation: induction of goosecoid by injected Xwnt-8 and activin mRNAs. Development (Cambridge, England). 118: 499-507. PMID 7900991  0.557
1993 Steinbeisser H, De Robertis EM. Xenopus goosecoid: a gene expressed in the prechordal plate that has dorsalizing activity. Comptes Rendus De L'Acadã©Mie Des Sciences. Sã©Rie Iii, Sciences De La Vie. 316: 959-71. PMID 7521271  0.339
1992 Niehrs C, De Robertis EM. Vertebrate axis formation. Current Opinion in Genetics & Development. 2: 550-5. PMID 1356042 DOI: 10.1016/S0959-437X(05)80170-4  0.55
1992 Blum M, Gaunt SJ, Cho KW, Steinbeisser H, Blumberg B, Bittner D, De Robertis EM. Gastrulation in the mouse: the role of the homeobox gene goosecoid. Cell. 69: 1097-106. PMID 1352187 DOI: 10.1016/0092-8674(92)90632-M  0.75
1992 Blumberg B, Mangelsdorf DJ, Dyck JA, Bittner DA, Evans RM, De Robertis EM. Multiple retinoid-responsive receptors in a single cell: families of retinoid "X" receptors and retinoic acid receptors in the Xenopus egg. Proceedings of the National Academy of Sciences of the United States of America. 89: 2321-5. PMID 1312717 DOI: 10.1073/Pnas.89.6.2321  0.625
1992 Jegalian BG, Miller RW, Wright CV, Blum M, De Robertis EM. A Hox 3.3-lacZ transgene expressed in developing limbs. Mechanisms of Development. 39: 171-80. PMID 1292571 DOI: 10.1016/0925-4773(92)90044-K  0.59
1991 Cho KW, Blumberg B, Steinbeisser H, De Robertis EM. Molecular nature of Spemann's organizer: the role of the Xenopus homeobox gene goosecoid. Cell. 67: 1111-20. PMID 1684739 DOI: 10.1016/0092-8674(91)90288-A  0.597
1991 Blumberg B, Wright CV, De Robertis EM, Cho KW. Organizer-specific homeobox genes in Xenopus laevis embryos. Science (New York, N.Y.). 253: 194-6. PMID 1677215 DOI: 10.1126/Science.1677215  0.589
1990 Molven A, Wright CV, Bremiller R, De Robertis EM, Kimmel CB. Expression of a homeobox gene product in normal and mutant zebrafish embryos: evolution of the tetrapod body plan. Development (Cambridge, England). 109: 279-88. PMID 1976086  0.305
1989 Wright CV, Schnegelsberg P, De Robertis EM. XlHbox 8: a novel Xenopus homeo protein restricted to a narrow band of endoderm. Development (Cambridge, England). 105: 787-94. PMID 2574662  0.316
1989 Oliver G, Sidell N, Fiske W, Heinzmann C, Mohandas T, Sparkes RS, De Robertis EM. Complementary homeo protein gradients in developing limb buds. Genes & Development. 3: 641-50. PMID 2568311  0.315
1989 Wright CV, Cho KW, Oliver G, De Robertis EM. Vertebrate homeodomain proteins: families of region-specific transcription factors. Trends in Biochemical Sciences. 14: 52-6. PMID 2565051 DOI: 10.1016/0968-0004(89)90043-1  0.309
1988 Cho KW, Goetz J, Wright CV, Fritz A, Hardwicke J, De Robertis EM. Differential utilization of the same reading frame in a Xenopus homeobox gene encodes two related proteins sharing the same DNA-binding specificity. The Embo Journal. 7: 2139-49. PMID 2901347  0.312
1988 Oliver G, Wright CV, Hardwicke J, De Robertis EM. Differential antero-posterior expression of two proteins encoded by a homeobox gene in Xenopus and mouse embryos. The Embo Journal. 7: 3199-209. PMID 2460338  0.357
1987 Bürglin TR, Mattaj IW, Newmeyer DD, Zeller R, De Robertis EM. Cloning of nucleoplasmin from Xenopus laevis oocytes and analysis of its developmental expression. Genes & Development. 1: 97-107. PMID 3428591 DOI: 10.1101/Gad.1.1.97  0.722
1987 Bürglin TR, De Robertis EM. The nuclear migration signal of Xenopus laevis nucleoplasmin. The Embo Journal. 6: 2617-25. PMID 3119324  0.35
1987 Sharpe CR, Fritz A, De Robertis EM, Gurdon JB. A homeobox-containing marker of posterior neural differentiation shows the importance of predetermination in neural induction. Cell. 50: 749-58. PMID 2441873 DOI: 10.1016/0092-8674(87)90333-3  0.541
1985 Mattaj IW, De Robertis EM. Nuclear segregation of U2 snRNA requires binding of specific snRNP proteins. Cell. 40: 111-8. PMID 2578319 DOI: 10.1016/0092-8674(85)90314-9  0.547
1985 Mattaj IW, Lienhard S, Jiricny J, De Robertis EM. An enhancer-like sequence within the Xenopus U2 gene promoter facilitates the formation of stable transcription complexes. Nature. 316: 163-7. PMID 2409453 DOI: 10.1038/316163a0  0.514
1984 Shepherd JC, McGinnis W, Carrasco AE, De Robertis EM, Gehring WJ. Fly and frog homoeo domains show homologies with yeast mating type regulatory proteins. Nature. 310: 70-1. PMID 6429549 DOI: 10.1038/310070a0  0.661
1984 Carrasco AE, McGinnis W, Gehring WJ, De Robertis EM. Cloning of an X. laevis gene expressed during early embryogenesis coding for a peptide region homologous to Drosophila homeotic genes. Cell. 37: 409-14. PMID 6327066 DOI: 10.1016/0092-8674(84)90371-4  0.669
1983 Zeller R, Nyffenegger T, De Robertis EM. Nucleocytoplasmic distribution of snRNPs and stockpiled snRNA-binding proteins during oogenesis and early development in Xenopus laevis. Cell. 32: 425-34. PMID 6186395 DOI: 10.1016/0092-8674(83)90462-2  0.61
1980 Melton DA, Cortese R, de Robertis EM, Trendelenburg MF, Gurdon JB. Gene injection into amphibian oocytes. Results and Problems in Cell Differentiation. 11: 8-14. PMID 7444205 DOI: 10.1007/978-3-540-38267-6_2  0.634
1980 Mills AD, Laskey RA, Black P, De Robertis EM. An acidic protein which assembles nucleosomes in vitro is the most abundant protein in Xenopus oocyte nuclei. Journal of Molecular Biology. 139: 561-8. PMID 7441745 DOI: 10.1016/0022-2836(80)90148-5  0.542
1980 Melton DA, De Robertis EM, Cortese R. Order and intracellular location of the events involved in the maturation of a spliced tRNA. Nature. 284: 143-8. PMID 6987526 DOI: 10.1038/284143a0  0.469
1979 De Robertis EM, Gurdon JB. Gene transplantation and the analysis of development. Scientific American. 241: 74-82. PMID 504982 DOI: 10.1038/Scientificamerican1279-74  0.429
1979 Gurdon JB, Laskey RA, De Robertis EM, Partington GA. Reprogramming of transplanted nuclei in amphibia. International Review of Cytology. Supplement. 161-78. PMID 385535  0.58
1979 Gurdon JB, Melton DA, De Robertis EM. Genetics in an oocyte. Ciba Foundation Symposium. 63-80. PMID 289482 DOI: 10.1002/9780470720486.ch5  0.593
1978 De Robertis EM, Longthorne RF, Gurdon JB. Intracellular migration of nuclear proteins in Xenopus oocytes. Nature. 272: 254-6. PMID 564468 DOI: 10.1038/272254A0  0.536
1978 De Robertis EM, Partington GA, Gurdon JB. Selective gene expression by somatic nuclei injected into amphibian oocytes. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 283: 375-7. PMID 26084 DOI: 10.1098/Rstb.1978.0040  0.512
1978 Gurdon JB, Wyllie AH, De Robertis EM. The transcription and translation of DNA injected into oocytes. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 283: 367-72. PMID 26082 DOI: 10.1098/Rstb.1978.0038  0.484
1977 De Robertis EM, Partington GA, Longthorne RF, Gurdon JB. Somatic nuclei in amphibian oocytes: evidence for selective gene expression. Journal of Embryology and Experimental Morphology. 40: 199-214. PMID 562385  0.529
1977 de Robertis EM, Gurdon JB, Partington GA, Mertz JE, Laskey RA. Injected amphibian oocytes: a living test tube for the study of eukaryotic gene transcription? Biochemical Society Symposium. 181-91. PMID 339919  0.763
1977 De Robertis EM, Gurdon JB. Gene activation in somatic nuclei after injection into amphibian oocytes. Proceedings of the National Academy of Sciences of the United States of America. 74: 2470-4. PMID 267940 DOI: 10.1073/Pnas.74.6.2470  0.526
1977 De Robertis EM, Mertz JE. Coupled transcription-translation of DNA injected into Xenopus oocytes. Cell. 12: 175-82. PMID 198138 DOI: 10.1016/0092-8674(77)90195-7  0.592
1976 Gurdon JB, Partington GA, De Robertis EM. Injected nuclei in frog oocytes:RNA synthesis and protein exchange. Journal of Embryology and Experimental Morphology. 36: 541-53. PMID 1010978  0.444
1976 Gurdon JB, De Robertis EM, Partington G. Injected nuclei in frog oocytes provide a living cell system for the study of transcriptional control. Nature. 260: 116-20. PMID 943701 DOI: 10.1038/260116A0  0.474
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