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James W. Simpkins - Publications

Affiliations: 
1977-2000 University of Florida, Gainesville, Gainesville, FL, United States 
 2000-2012 University of North Texas Health Science Center at Fort Worth 
 2012- West Virginia University, Morgantown, WV, United States 
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Year Citation  Score
2023 Bumgarner JR, Walker WH, Quintana DD, White RC, Richmond AA, Meléndez-Fernández OH, Liu JA, Becker-Krail DD, Walton JC, Simpkins JW, DeVries AC, Nelson RJ. Acute exposure to artificial light at night alters hippocampal vascular structure in mice. Iscience. 26: 106996. PMID 37534143 DOI: 10.1016/j.isci.2023.106996  0.748
2022 Hu C, Liu B, Wang S, Zhu Z, Adcock A, Simpkins J, Li X. Spatiotemporal Correlation Analysis of Hydraulic Fracturing and Stroke in the United States. International Journal of Environmental Research and Public Health. 19. PMID 36078531 DOI: 10.3390/ijerph191710817  0.687
2021 Quintana DD, Anantula Y, Garcia JA, Engler-Chiurazzi EB, Sarkar SN, Corbin DR, Brown CM, Simpkins JW. Microvascular degeneration occurs before plaque onset and progresses with age in 3xTg AD mice. Neurobiology of Aging. 105: 115-128. PMID 34062487 DOI: 10.1016/j.neurobiolaging.2021.04.019  0.777
2021 Kim SJ, Russell AE, Wang W, Gemoets DE, Sarkar SN, Simpkins JW, Brown CM. miR-146a Dysregulates Energy Metabolism During Neuroinflammation. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. PMID 34028667 DOI: 10.1007/s11481-021-09999-y  0.788
2021 Ren X, Hu H, Farooqi I, Simpkins JW. Author Correction: Blood substitution therapy rescues the brain of mice from ischemic damage. Nature Communications. 12: 2957. PMID 33986263 DOI: 10.1038/s41467-021-22615-0  0.776
2021 Saralkar P, Mdzinarishvili A, Arsiwala TA, Lee YK, Sullivan PG, Pinti MV, Hollander JM, Kelley EE, Ren X, Hu H, Simpkins J, Brown C, Hazlehurst LE, Huber JD, Geldenhuys WJ. The Mitochondrial mitoNEET Ligand NL-1 Is Protective in a Murine Model of Transient Cerebral Ischemic Stroke. Pharmaceutical Research. PMID 33982226 DOI: 10.1007/s11095-021-03046-4  0.806
2021 Quintana D, Ren X, Hu H, Corbin D, Engler-Chiurazzi E, Alvi M, Simpkins J. IL-1β Antibody Protects Brain from Neuropathology of Hypoperfusion. Cells. 10. PMID 33918659 DOI: 10.3390/cells10040855  0.781
2021 Russell AE, Cavendish JZ, Rai A, Vannoy M, Dakhlallah AH, Hu H, Ren X, Amer A, Brown CM, Marsh CB, Simpkins JW, Dakhlallah D. Intermittent Lipopolysaccharide Exposure Significantly Increases Cortical Infarct Size and Impairs Autophagy. Asn Neuro. 13: 1759091421991769. PMID 33626880 DOI: 10.1177/1759091421991769  0.791
2021 Gao X, Boryczka J, Zheng P, Kasani S, Yang F, Engler-Chiurazzi EB, Simpkins JW, Wigginton JG, Wu N. A "hot Spot"-Enhanced paper lateral flow assay for ultrasensitive detection of traumatic brain injury biomarker S-100β in blood plasma. Biosensors & Bioelectronics. 177: 112967. PMID 33429202 DOI: 10.1016/j.bios.2021.112967  0.774
2020 Ren X, Hu H, Farooqi I, Simpkins JW. Blood substitution therapy rescues the brain of mice from ischemic damage. Nature Communications. 11: 4078. PMID 32843630 DOI: 10.1038/S41467-020-17930-X  0.796
2020 Porter KN, Sarkar SN, Dakhlallah DA, Vannoy ME, Quintana DD, Simpkins JW. Medroxyprogesterone Acetate Impairs Amyloid Beta Degradation in a Matrix Metalloproteinase-9 Dependent Manner. Frontiers in Aging Neuroscience. 12: 92. PMID 32317959 DOI: 10.3389/Fnagi.2020.00092  0.782
2020 Sarvari S, Moakedi F, Hone E, Simpkins JW, Ren X. Mechanisms in blood-brain barrier opening and metabolism-challenged cerebrovascular ischemia with emphasis on ischemic stroke. Metabolic Brain Disease. PMID 32297170 DOI: 10.1007/S11011-020-00573-8  0.708
2020 Quintana DD, Garcia JA, Anantula Y, Rellick SL, Engler-Chiurazzi EB, Sarkar SN, Brown CM, Simpkins JW. Amyloid-β Causes Mitochondrial Dysfunction via a Ca2+-Driven Upregulation of Oxidative Phosphorylation and Superoxide Production in Cerebrovascular Endothelial Cells. Journal of Alzheimer's Disease : Jad. PMID 32250296 DOI: 10.3233/Jad-190964  0.787
2020 Hu H, Hone EA, Provencher EAP, Sprowls SA, Farooqi I, Corbin DR, Sarkar SN, Hollander JM, Lockman PR, Simpkins JW, Ren X. MiR-34a Interacts with Cytochrome c and Shapes Stroke Outcomes. Scientific Reports. 10: 3233. PMID 32094435 DOI: 10.1038/S41598-020-59997-Y  0.786
2019 Quintana DD, Lewis SE, Anantula Y, Garcia JA, Sarkar SN, Cavendish JZ, Brown CM, Simpkins JW. The cerebral angiome: High resolution MicroCT imaging of the whole brain cerebrovasculature in female and male mice. Neuroimage. 116109. PMID 31446129 DOI: 10.1016/J.Neuroimage.2019.116109  0.776
2019 Sarkar S, Engler-Chiurazzi EB, Cavendish JZ, Povroznik JM, Russell AE, Quintana DD, Mathers PH, Simpkins JW. Over-expression of miR-34a Induces Rapid Cognitive Impairment and Alzheimer's Disease-like Pathology. Brain Research. 146327. PMID 31295467 DOI: 10.1016/J.Brainres.2019.146327  0.77
2019 Cavendish JZ, Sarkar SN, Colantonio MA, Quintana DD, Ahmed N, White BA, Engler-Chiurazzi EB, Simpkins JW. Mitochondrial Movement and Number Deficits in Embryonic Cortical Neurons from 3xTg-AD Mice. Journal of Alzheimer's Disease : Jad. PMID 31177221 DOI: 10.3233/Jad-190143  0.783
2019 Sarkar SN, Russell AE, Engler-Chiurazzi EB, Porter KN, Simpkins JW. MicroRNAs and the Genetic Nexus of Brain Aging, Neuroinflammation, Neurodegeneration, and Brain Trauma. Aging and Disease. 10: 329-352. PMID 31011481 DOI: 10.14336/Ad.2018.0409  0.783
2019 Russell AE, Jun S, Sarkar S, Geldenhuys WJ, Lewis SE, Rellick SL, Simpkins JW. Extracellular Vesicles Secreted in Response to Cytokine Exposure Increase Mitochondrial Oxygen Consumption in Recipient Cells. Frontiers in Cellular Neuroscience. 13: 51. PMID 30837842 DOI: 10.3389/Fncel.2019.00051  0.792
2018 Grasmick KA, Hu H, Hone EA, Farooqi I, Rellick SL, Simpkins JW, Ren X. Uncoupling of the Electron Transport Chain Compromises Mitochondrial Oxidative Phosphorylation and Exacerbates Stroke Outcomes. Journal of Neuroinfectious Diseases. 9. PMID 32149160 DOI: 10.4172/2314-7326.1000283  0.792
2018 Quintana DD, Garcia JA, Sarkar SN, Jun S, Engler-Chiurazzi EB, Russell AE, Cavendish JZ, Simpkins JW. Hypoxia-reoxygenation of primary astrocytes results in a redistribution of mitochondrial size and mitophagy. Mitochondrion. PMID 30594729 DOI: 10.1016/J.Mito.2018.12.004  0.777
2018 Sprenkle NT, Lahiri A, Simpkins JW, Meares GP. Endoplasmic reticulum stress is transmissible in vitro between cells of the central nervous system. Journal of Neurochemistry. PMID 30520047 DOI: 10.1111/Jnc.14642  0.71
2018 Ren X, Engler-Chiurazzi EB, Russell AE, Sarkar SN, Rellick SL, Lewis S, Corbin D, Clapper J, Simpkins JW. MiR-34a and stroke: Assessment of non-modifiable biological risk factors in cerebral ischemia. Neurochemistry International. PMID 30365981 DOI: 10.1016/J.Neuint.2018.10.019  0.791
2018 Quintana DD, Ren X, Hu H, Engler-Chiurazzi EB, Rellick SL, Lewis SE, Povroznik JM, Simpkins JW, Alvi M. Gradual common carotid artery occlusion as a novel model for cerebrovascular Hypoperfusion. Metabolic Brain Disease. PMID 30267298 DOI: 10.1007/S11011-018-0312-5  0.784
2018 Poteet E, Choudhury GR, Winters A, Li W, Ryou MG, Liu R, Tang L, Ghorpade A, Wen Y, Yuan F, Keir ST, Yan H, Bigner DD, Simpkins JW, Yang SH. Correction: Reversing the Warburg effect as a treatment for glioblastoma. The Journal of Biological Chemistry. 293: 14973. PMID 30266879 DOI: 10.1074/Jbc.Aac118.005625  0.766
2018 Ren X, Quintana D, Hu H, Lewis S, Rellick S, Simpkins JW, Alvi M. Abstract WP417: Novel Animal Model for Cerebral Small Vessel Disease Stroke. 49. DOI: 10.1161/Str.49.Suppl_1.Wp417  0.787
2017 Wu J, Li R, Li W, Ren M, Thangthaeng N, Sumien N, Liu R, Yang S, Simpkins JW, Forster MJ, Yan LJ. Administration of 5-methoxyindole-2-carboxylic acid that potentially targets mitochondrial dihydrolipoamide dehydrogenase confers cerebral preconditioning against ischemic stroke injury. Free Radical Biology & Medicine. PMID 29017857 DOI: 10.1016/J.Freeradbiomed.2017.10.008  0.811
2017 Gao X, Zheng P, Kasani S, Wu S, Yang F, Lewis S, Nayeem S, Engler-Chiurazzi E, Wigginton J, Simpkins JW, Wu N. A Paper-based Surface-Enhanced Raman Scattering Lateral Flow Strip for Detection of Neuron-Specific Enolase in Blood Plasma. Analytical Chemistry. PMID 28817769 DOI: 10.1021/Acs.Analchem.7B03015  0.769
2017 Asano S, O'Connell GC, Lemaster KC, DeVallance ER, Branyan KW, Simpkins JW, Frisbee JC, Barr TL, Chantler PD. Circulating leukocytes perpetuate stroke-induced aortic dysfunction. Experimental Physiology. PMID 28737253 DOI: 10.1113/Ep086510  0.766
2017 Simpkins JW, Engler-Chiurazzi EB. Role of non-feminizing estrogens in brain protection from cerebral ischemia and Alzheimer’s disease neuropathology Experimental Gerontology. 94: 120. DOI: 10.1016/J.Exger.2017.02.047  0.802
2017 Engler-Chiurazzi EB, Clapper J, Lewis SE, Lamb R, Simpkins JW. Interactions between circulating microRNA expression and hormonal control of reproductive function in aging rats Experimental Gerontology. 94: 112. DOI: 10.1016/J.Exger.2017.02.023  0.777
2016 Russell AE, Doll DN, Sarkar SN, Simpkins JW. TNF-α and Beyond: Rapid Mitochondrial Dysfunction Mediates TNF-α-Induced Neurotoxicity. Journal of Clinical & Cellular Immunology. 7. PMID 28652929 DOI: 10.4172/2155-9899.1000467  0.788
2016 Rellick SL, Hu H, Simpkins JW, Ren X. Evaluation of Bioenergetic Function in Cerebral Vascular Endothelial Cells. Journal of Visualized Experiments : Jove. PMID 27911398 DOI: 10.3791/54847  0.791
2016 Engler-Chiurazzi EB, Covey DF, Simpkins JW. A novel mechanism of non-feminizing estrogens in neuroprotection. Experimental Gerontology. PMID 27818250 DOI: 10.1016/J.Exger.2016.10.013  0.812
2016 Qian M, Engler-Chiurazzi EB, Lewis SE, Rath NP, Simpkins JW, Covey DF. Structure-activity studies of non-steroid analogues structurally-related to neuroprotective estrogens. Organic & Biomolecular Chemistry. PMID 27714297 DOI: 10.1039/C6Ob01726F  0.783
2016 Engler-Chiurazzi EB, Singh M, Simpkins JW. Reprint of: From the 90׳s to now: A brief historical perspective on more than two decades of estrogen neuroprotection. Brain Research. PMID 27317847 DOI: 10.1016/j.brainres.2016.06.016  0.805
2016 Sarkar S, Jun S, Rellick S, Quintana DD, Cavendish JZ, Simpkins JW. Expression of MicroRNA-34a in Alzheimer's Disease Brain Targets Genes Linked to Synaptic Plasticity, Energy Metabolism, and Resting State Network Activity. Brain Research. PMID 27235866 DOI: 10.1016/J.Brainres.2016.05.026  0.772
2016 Sun J, Ren X, Med WQ, Yuan D, Simpkins JW. Geissoschizine Methyl Ether Protects Oxidative Stress-mediated Cytotoxicity in Neurons through the 'Neuronal Warburg Effect'. Journal of Ethnopharmacology. PMID 27114061 DOI: 10.1016/J.Jep.2016.04.034  0.696
2016 Engler-Chiurazzi EB, Stapleton PA, Stalnaker JJ, Ren X, Hu H, Nurkiewicz TR, McBride CR, Yi J, Engels K, Simpkins JW. Impacts of prenatal nanomaterial exposure on male adult sprague-dawley rat behavior and cognition. Journal of Toxicology and Environmental Health. Part A. 1-6. PMID 27092594 DOI: 10.1080/15287394.2016.1164101  0.771
2016 Engler-Chiurazzi EB, Brown CM, Povroznik JM, Simpkins JW. Estrogens as neuroprotectants: Estrogenic actions in the context of cognitive aging and brain injury. Progress in Neurobiology. PMID 26891883 DOI: 10.1016/J.Pneurobio.2015.12.008  0.801
2016 Sun J, Hu H, Ren X, Simpkins JW. Tert-butylhydroquinone compromises survival in murine experimental stroke. Neurotoxicology and Teratology. PMID 26827673 DOI: 10.1016/J.Ntt.2016.01.004  0.81
2016 Hu H, Doll DN, Sun J, Lewis SE, Wimsatt JH, Kessler MJ, Simpkins JW, Ren X. Mitochondrial Impairment in Cerebrovascular Endothelial Cells is Involved in the Correlation between Body Temperature and Stroke Severity. Aging and Disease. 7: 14-27. PMID 26816660 DOI: 10.14336/Ad.2015.0906  0.787
2015 Ren X, Simpkins JW. Deciphering the Blood-Brain Barrier Damage in Stroke: Mitochondrial Mechanism. Journal of Neuroinfectious Diseases. 6. PMID 27213159 DOI: 10.4172/2314-7326.S2-E002  0.714
2015 Engler-Chiurazzi EB, Singh M, Simpkins JW. From the 90's to Now: a Brief Historical Perspective on More Than Two Decades of Estrogen Neuroprotection. Brain Research. PMID 26740397 DOI: 10.1016/J.Brainres.2015.12.044  0.805
2015 Bukeirat M, Sarkar SN, Hu H, Quintana DD, Simpkins JW, Ren X. MiR-34a regulates blood-brain barrier permeability and mitochondrial function by targeting cytochrome c. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 26661155 DOI: 10.1177/0271678X15606147  0.779
2015 Yang SH, Li W, Sumien N, Forster M, Simpkins JW, Liu R. Alternative Mitochondrial Electron Transfer for the Treatment of Neurodegenerative Diseases and Cancers: Methylene Blue Connects the Dots. Progress in Neurobiology. PMID 26603930 DOI: 10.1016/J.Pneurobio.2015.10.005  0.791
2015 Petrone AB, O'Connell GC, Regier MD, Chantler PD, Simpkins JW, Barr TL. The Role of Arginase 1 in Post-Stroke Immunosuppression and Ischemic Stroke Severity. Translational Stroke Research. PMID 26515089 DOI: 10.1007/S12975-015-0431-9  0.76
2015 Doll DN, Engler-Chiurazzi EB, Lewis SE, Hu H, Kerr AE, Ren X, Simpkins JW. Lipopolysaccharide exacerbates infarct size and results in worsened post-stroke behavioral outcomes. Behavioral and Brain Functions : Bbf. 11: 32. PMID 26463864 DOI: 10.1186/S12993-015-0077-5  0.78
2015 Breckenridge CB, Sawhney Coder P, Tisdel MO, Simpkins JW, Yi KD, Foradori CD, Handa RJ. Effect of Age, Duration of Exposure, and Dose of Atrazine on Sexual Maturation and the Luteinizing Hormone Surge in the Female Sprague-Dawley Rat. Birth Defects Research. Part B, Developmental and Reproductive Toxicology. PMID 26439775 DOI: 10.1002/Bdrb.21154  0.666
2015 Moses BS, Slone WL, Thomas P, Evans R, Piktel D, Angel PM, Walsh CM, Cantrell PS, Rellick SL, Martin KH, Simpkins JW, Gibson LF. Bone Marrow Microenvironment Modulation of Acute Lymphoblastic Leukemia Phenotype. Experimental Hematology. PMID 26407636 DOI: 10.1016/J.Exphem.2015.09.003  0.692
2015 Tan Z, Lucke-Wold BP, Logsdon AF, Turner RC, Tan C, Li X, Hongpaison J, Alkon DL, Simpkins JW, Rosen CL, Huber JD. Bryostatin extends tPA time window to 6h following middle cerebral artery occlusion in aged female rats. European Journal of Pharmacology. 764: 404-412. PMID 26189021 DOI: 10.1016/J.Ejphar.2015.07.035  0.621
2015 Logsdon AF, Lucke-Wold BP, Turner RC, Huber JD, Rosen CL, Simpkins JW. Role of Microvascular Disruption in Brain Damage from Traumatic Brain Injury. Comprehensive Physiology. 5: 1147-60. PMID 26140712 DOI: 10.1002/Cphy.C140057  0.327
2015 Sun J, Ren X, Simpkins JW. Sequential Up-Regulation of SOD2 and HO-1 by Tert-Butylhydroquinone Protects Mitochondria During Oxidative Stress. Molecular Pharmacology. PMID 26082377 DOI: 10.1124/Mol.115.098269  0.709
2015 Sarkar S, Jun S, Simpkins JW. Estrogen amelioration of Aβ-induced defects in mitochondria is mediated by mitochondrial signaling pathway involving ERβ, AKAP and Drp1. Brain Research. 1616: 101-11. PMID 25964165 DOI: 10.1016/J.Brainres.2015.04.059  0.784
2015 Doll DN, Hu H, Sun J, Lewis SE, Simpkins JW, Ren X. Mitochondrial crisis in cerebrovascular endothelial cells opens the blood-brain barrier. Stroke; a Journal of Cerebral Circulation. 46: 1681-9. PMID 25922503 DOI: 10.1161/Strokeaha.115.009099  0.79
2015 Gatson JW, Simpkins JW, Uteshev VV. High therapeutic potential of positive allosteric modulation of α7 nAChRs in a rat model of traumatic brain injury: proof-of-concept. Brain Research Bulletin. 112: 35-41. PMID 25647232 DOI: 10.1016/J.Brainresbull.2015.01.008  0.789
2015 Doll DN, Rellick SL, Barr TL, Ren X, Simpkins JW. Rapid mitochondrial dysfunction mediates TNF-alpha-induced neurotoxicity. Journal of Neurochemistry. 132: 443-51. PMID 25492727 DOI: 10.1111/Jnc.13008  0.775
2015 Lucke-Wold BP, Turner RC, Logsdon AF, Simpkins JW, Alkon DL, Smith KE, Chen YW, Tan Z, Huber JD, Rosen CL. Common mechanisms of Alzheimer's disease and ischemic stroke: the role of protein kinase C in the progression of age-related neurodegeneration. Journal of Alzheimer's Disease : Jad. 43: 711-24. PMID 25114088 DOI: 10.3233/Jad-141422  0.355
2015 Petrone AB, Rudy CC, Barr TL, Simpkins JW, Reed MN. Neuroprotective Effects of Estrogen Following Neural Injury Estrogen Effects On Traumatic Brain Injury: Mechanisms of Neuroprotection and Repair. 91-111. DOI: 10.1016/B978-0-12-801479-0.00007-3  0.729
2014 Brinkman SD, Reese RJ, Norsworthy LA, Dellaria DK, Kinkade JW, Benge J, Brown K, Ratka A, Simpkins JW. Validation of a self-administered computerized system to detect cognitive impairment in older adults. Journal of Applied Gerontology : the Official Journal of the Southern Gerontological Society. 33: 942-62. PMID 25332303 DOI: 10.1177/0733464812455099  0.624
2014 Petrone AB, Simpkins JW, Barr TL. 17β-estradiol and inflammation: implications for ischemic stroke. Aging and Disease. 5: 340-5. PMID 25276492 DOI: 10.14336/Ad.2014.0500340  0.7
2014 Doll DN, Barr TL, Simpkins JW. Cytokines: their role in stroke and potential use as biomarkers and therapeutic targets. Aging and Disease. 5: 294-306. PMID 25276489 DOI: 10.14336/Ad.2014.0500294  0.781
2014 Barr TL, Simpkins J. Ischemic stroke: a consequence of a diseased immune system? Aging and Disease. 5: 292-3. PMID 25276488 DOI: 10.14336/Ad.2014.0500292  0.671
2014 Li W, Huang R, Chen Z, Yan LJ, Simpkins JW, Yang SH. PTEN degradation after ischemic stroke: a double-edged sword. Neuroscience. 274: 153-61. PMID 24875179 DOI: 10.1016/J.Neuroscience.2014.05.027  0.785
2014 Foradori CD, Sawhney Coder P, Tisdel M, Yi KD, Simpkins JW, Handa RJ, Breckenridge CB. The effect of atrazine administered by gavage or in diet on the LH surge and reproductive performance in intact female Sprague-Dawley and Long Evans rats. Birth Defects Research. Part B, Developmental and Reproductive Toxicology. 101: 262-75. PMID 24831581 DOI: 10.1002/Bdrb.21109  0.706
2014 Xie L, Sun F, Wang J, Mao X, Xie L, Yang SH, Su DM, Simpkins JW, Greenberg DA, Jin K. mTOR signaling inhibition modulates macrophage/microglia-mediated neuroinflammation and secondary injury via regulatory T cells after focal ischemia. Journal of Immunology (Baltimore, Md. : 1950). 192: 6009-19. PMID 24829408 DOI: 10.4049/Jimmunol.1303492  0.67
2014 Petrone AB, Gatson JW, Simpkins JW, Reed MN. Non-feminizing estrogens: a novel neuroprotective therapy. Molecular and Cellular Endocrinology. 389: 40-7. PMID 24424441 DOI: 10.1016/J.Mce.2013.12.017  0.806
2014 Phillips NR, Simpkins JW, Roby RK. Mitochondrial DNA deletions in Alzheimer's brains: a review. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: 393-400. PMID 23850329 DOI: 10.1016/J.Jalz.2013.04.508  0.305
2014 Barr TL, Simpkins J. Ischemic stroke: A consequence of a diseased immune system? Aging and Disease. 5: 292-293. DOI: 10.14336/AD.2014.0500292  0.627
2013 Li W, Huang R, Shetty RA, Thangthaeng N, Liu R, Chen Z, Sumien N, Rutledge M, Dillon GH, Yuan F, Forster MJ, Simpkins JW, Yang SH. Transient focal cerebral ischemia induces long-term cognitive function deficit in an experimental ischemic stroke model. Neurobiology of Disease. 59: 18-25. PMID 23845275 DOI: 10.1016/J.Nbd.2013.06.014  0.801
2013 Singh M, Simpkins JW, Simpkins JW, Bimonte-Nelson HA, Bimonte-Nelson HA, Brinton RD, Brinton RD. Window of opportunity for estrogen and progestin intervention in brain aging and Alzheimer's disease. Brain Research. 1514: 1-2. PMID 23726132 DOI: 10.1016/J.Brainres.2013.04.044  0.778
2013 Richardson TE, Kelly HN, Yu AE, Simpkins JW. Therapeutic strategies in Friedreich's ataxia. Brain Research. 1514: 91-7. PMID 23587934 DOI: 10.1016/J.Brainres.2013.04.005  0.751
2013 Lincoln KM, Gonzalez P, Richardson TE, Julovich DA, Saunders R, Simpkins JW, Green KN. A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders. Chemical Communications (Cambridge, England). 49: 2712-4. PMID 23437435 DOI: 10.1039/c2cc36808k  0.708
2013 Poteet E, Choudhury GR, Winters A, Li W, Ryou MG, Liu R, Tang L, Ghorpade A, Wen Y, Yuan F, Keir ST, Yan H, Bigner DD, Simpkins JW, Yang SH. Reversing the Warburg effect as a treatment for glioblastoma. The Journal of Biological Chemistry. 288: 9153-64. PMID 23408428 DOI: 10.1074/Jbc.M112.440354  0.782
2013 Li W, Winters A, Poteet E, Ryou MG, Lin S, Hao S, Wu Z, Yuan F, Hatanpaa KJ, Simpkins JW, Yang SH. Involvement of estrogen receptor β5 in the progression of glioma. Brain Research. 1503: 97-107. PMID 23399685 DOI: 10.1016/J.Brainres.2013.02.004  0.789
2013 Simpkins JW, Richardson TE, Yi KD, Perez E, Covey DF. Neuroprotection with non-feminizing estrogen analogues: an overlooked possible therapeutic strategy. Hormones and Behavior. 63: 278-83. PMID 22498694 DOI: 10.1016/J.Yhbeh.2012.03.013  0.798
2013 Wigginton J, Pepe P, Warren V, AbdelFattah K, Gaston J, Simpkins J, Minei J, Maass D, Idris A. Feasibility and experience of using exception from informed consent in a pilot study of immediate estrogen infusion for hypotensive trauma patients Critical Care. 17: 288. DOI: 10.1186/Cc12226  0.633
2013 Pepe P, Wigginton J, Gatson J, Simpkins J, Maass D, AbdelFattah K, Idris A, Warren V, Minei J. Single-dose estrogen infusion can amplify brain levels of Sonic hedgehog, a signal protein for neuro stem cells and repair following the indirect brain injury resulting after severe torso burns Critical Care. 17: 287. DOI: 10.1186/Cc12225  0.796
2012 Lincoln KM, Richardson TE, Rutter L, Gonzalez P, Simpkins JW, Green KN. An N-heterocyclic amine chelate capable of antioxidant capacity and amyloid disaggregation. Acs Chemical Neuroscience. 3: 919-27. PMID 23173072 DOI: 10.1021/Cn300060V  0.743
2012 Poteet E, Winters A, Yan LJ, Shufelt K, Green KN, Simpkins JW, Wen Y, Yang SH. Neuroprotective actions of methylene blue and its derivatives. Plos One. 7: e48279. PMID 23118969 DOI: 10.1371/Journal.Pone.0048279  0.791
2012 Richardson TE, Simpkins JW. R- and S-equol have equivalent cytoprotective effects in Friedreich's ataxia. Bmc Pharmacology & Toxicology. 13: 12. PMID 23088310 DOI: 10.1186/2050-6511-13-12  0.63
2012 Nixon E, Simpkins JW. Neuroprotective effects of nonfeminizing estrogens in retinal photoreceptor neurons. Investigative Ophthalmology & Visual Science. 53: 4739-47. PMID 22700711 DOI: 10.1167/Iovs.12-9517  0.799
2012 Simpkins JW, Singh M, Brock C, Etgen AM. Neuroprotection and estrogen receptors. Neuroendocrinology. 96: 119-30. PMID 22538356 DOI: 10.1159/000338409  0.719
2012 Richardson TE, Yu AE, Wen Y, Yang SH, Simpkins JW. Estrogen prevents oxidative damage to the mitochondria in Friedreich's ataxia skin fibroblasts. Plos One. 7: e34600. PMID 22509330 DOI: 10.1371/Journal.Pone.0034600  0.802
2012 Gatson JW, Liu MM, Abdelfattah K, Wigginton JG, Smith S, Wolf S, Simpkins JW, Minei JP. Estrone is neuroprotective in rats after traumatic brain injury. Journal of Neurotrauma. 29: 2209-19. PMID 22435710 DOI: 10.1089/Neu.2011.2274  0.801
2012 Luedtke RR, Perez E, Yang SH, Liu R, Vangveravong S, Tu Z, Mach RH, Simpkins JW. Neuroprotective effects of high affinity Σ1 receptor selective compounds. Brain Research. 1441: 17-26. PMID 22285434 DOI: 10.1016/J.Brainres.2011.12.047  0.781
2012 Jung ME, Ju X, Metzger DB, Simpkins JW. Ethanol withdrawal hastens the aging of cytochrome c oxidase. Neurobiology of Aging. 33: 618.e21-32. PMID 21439684 DOI: 10.1016/J.Neurobiolaging.2011.02.002  0.793
2012 Wigginton J, Pepe P, Simpkins J, Gatson J, Wigginton K, Kareem K, Minei J, Maass D. Early administration of parenteral estrogen suppresses the deleterious local and systemic inflammatory response in severe burns. Critical Care. 16: 465. DOI: 10.1186/Cc11072  0.777
2012 Wigginton J, Simpkins J, Pepe P, Maass D, Warren V, Gatson J, Minei J, Wolf S, Idris A. 202 Critical Care Medicine. 40: 1-328. DOI: 10.1097/01.Ccm.0000424422.97924.45  0.776
2012 Gatson J, Simpkins J, Wigginton J, Liu M, AbdelFattah K, Wolf S, Minei J. P1-224: Estrone decreases the levels of beta-amyloid in the cerebral cortex and corpus callosum after brain injury Alzheimer's & Dementia. 8: P185-P186. DOI: 10.1016/J.Jalz.2012.05.503  0.788
2011 Richardson TE, Yang SH, Wen Y, Simpkins JW. Estrogen protection in Friedreich's ataxia skin fibroblasts. Endocrinology. 152: 2742-9. PMID 21540287 DOI: 10.1210/En.2011-0184  0.784
2011 Wen Y, Li W, Poteet EC, Xie L, Tan C, Yan LJ, Ju X, Liu R, Qian H, Marvin MA, Goldberg MS, She H, Mao Z, Simpkins JW, Yang SH. Alternative mitochondrial electron transfer as a novel strategy for neuroprotection. The Journal of Biological Chemistry. 286: 16504-15. PMID 21454572 DOI: 10.1074/Jbc.M110.208447  0.799
2011 Nguyen HP, Tedmon L, Li L, Wigginton JG, Maass D, Gatson JW, Simpkins JW, Schug KA. Investigation of the temperature stability of premarin intravenous using liquid chromatography-mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. 55: 1218-22. PMID 21444176 DOI: 10.1016/J.Jpba.2011.03.003  0.763
2011 Logan SM, Sarkar SN, Zhang Z, Simpkins JW. Estrogen-induced signaling attenuates soluble Aβ peptide-mediated dysfunction of pathways in synaptic plasticity. Brain Research. 1383: 1-12. PMID 21262203 DOI: 10.1016/J.Brainres.2011.01.038  0.779
2011 Nguyen HP, Li L, Gatson JW, Maass D, Wigginton JG, Simpkins JW, Schug KA. Simultaneous quantification of four native estrogen hormones at trace levels in human cerebrospinal fluid using liquid chromatography-tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. 54: 830-7. PMID 21145681 DOI: 10.1016/J.Jpba.2010.11.014  0.784
2011 Walf AA, Paris JJ, Rhodes ME, Simpkins JW, Frye CA. Divergent mechanisms for trophic actions of estrogens in the brain and peripheral tissues. Brain Research. 1379: 119-36. PMID 21130078 DOI: 10.1016/J.Brainres.2010.11.081  0.342
2011 Yi KD, Perez E, Yang S, Liu R, Covey DF, Simpkins JW. The assessment of non-feminizing estrogens for use in neuroprotection. Brain Research. 1379: 61-70. PMID 21111714 DOI: 10.1016/J.Brainres.2010.11.058  0.794
2011 Gatson JW, Simpkins JW, Yi KD, Idris AH, Minei JP, Wigginton JG. Aromatase is increased in astrocytes in the presence of elevated pressure. Endocrinology. 152: 207-13. PMID 21047944 DOI: 10.1210/En.2010-0724  0.789
2011 Jung ME, Ju X, Simpkins JW, Metzger DB, Yan LJ, Wen Y. Ethanol withdrawal acts as an age-specific stressor to activate cerebellar p38 kinase. Neurobiology of Aging. 32: 2266-78. PMID 20122756 DOI: 10.1016/J.Neurobiolaging.2010.01.005  0.798
2011 Richardson T, Yang S, Wen Y, Simpkins J. P4-434: Effects of estrogen in a friedreich's ataxia disease model Alzheimer's & Dementia. 7: e63-e63. DOI: 10.1016/J.Jalz.2011.09.130  0.764
2011 Sarkar S, Simpkins J. P3-231: Estrogen signaling prevents Abeta-induced defects in dendritic mitochondial structure and mobility Alzheimer's & Dementia. 7: S589-S589. DOI: 10.1016/J.Jalz.2011.05.1673  0.713
2010 Ill-Raga G, Ramos-Fernández E, Guix FX, Tajes M, Bosch-Morató M, Palomer E, Godoy J, Belmar S, Cerpa W, Simpkins JW, Inestrosa And NC, Muñoz FJ. Amyloid-β peptide fibrils induce nitro-oxidative stress in neuronal cells. Journal of Alzheimer's Disease : Jad. 22: 641-52. PMID 20858976 DOI: 10.3233/Jad-2010-100474  0.319
2010 Xie L, Poteet EC, Li W, Scott AE, Liu R, Wen Y, Ghorpade A, Simpkins JW, Yang SH. Modulation of polymorphonuclear neutrophil functions by astrocytes. Journal of Neuroinflammation. 7: 53. PMID 20828397 DOI: 10.1186/1742-2094-7-53  0.784
2010 Zhang Z, Simpkins JW. An okadaic acid-induced model of tauopathy and cognitive deficiency. Brain Research. 1359: 233-46. PMID 20807517 DOI: 10.1016/J.Brainres.2010.08.077  0.483
2010 Sarkar SN, Smith LT, Logan SM, Simpkins JW. Estrogen-induced activation of extracellular signal-regulated kinase signaling triggers dendritic resident mRNA translation. Neuroscience. 170: 1080-5. PMID 20691769 DOI: 10.1016/J.Neuroscience.2010.07.035  0.775
2010 Zhang Z, Simpkins JW. Okadaic acid induces tau phosphorylation in SH-SY5Y cells in an estrogen-preventable manner. Brain Research. 1345: 176-81. PMID 20457142 DOI: 10.1016/J.Brainres.2010.04.074  0.488
2010 Nguyen HP, Yang SH, Wigginton JG, Simpkins JW, Schug KA. Retention behavior of estrogen metabolites on hydrophilic interaction chromatography stationary phases. Journal of Separation Science. 33: 793-802. PMID 20201045 DOI: 10.1002/Jssc.200900680  0.633
2010 Liu R, Liu Q, He S, Simpkins JW, Yang SH. Combination therapy of 17beta-estradiol and recombinant tissue plasminogen activator for experimental ischemic stroke. The Journal of Pharmacology and Experimental Therapeutics. 332: 1006-12. PMID 19952306 DOI: 10.1124/Jpet.109.160937  0.723
2010 Simpkins JW, Yi KD, Yang SH, Dykens JA. Mitochondrial mechanisms of estrogen neuroprotection. Biochimica Et Biophysica Acta. 1800: 1113-20. PMID 19931595 DOI: 10.1016/J.Bbagen.2009.11.013  0.806
2010 Gatson J, Simpkins J, Wigginton J. P3-257: Measurement of amyloid-β and neuronal specific enolase as a predictor of outcome in patients suffering from traumatic brain injury Alzheimer's & Dementia. 6: S526-S527. DOI: 10.1016/J.Jalz.2010.05.1757  0.78
2009 Simpkins JW, Perez E, Wang X, Yang S, Wen Y, Singh M. The potential for estrogens in preventing Alzheimer's disease and vascular dementia. Therapeutic Advances in Neurological Disorders. 2: 31-49. PMID 19890493 DOI: 10.1177/1756285608100427  0.796
2009 Gatson JW, Maass DL, Simpkins JW, Idris AH, Minei JP, Wigginton JG. Estrogen treatment following severe burn injury reduces brain inflammation and apoptotic signaling. Journal of Neuroinflammation. 6: 30. PMID 19849845 DOI: 10.1186/1742-2094-6-30  0.803
2009 Simpkins JW, Brown K, Bae S, Ratka A. Role of ethnicity in the expression of features of hot flashes. Maturitas. 63: 341-6. PMID 19592184 DOI: 10.1016/J.Maturitas.2009.06.002  0.622
2009 Prokai-Tatrai K, Prokai L, Simpkins JW, Jung ME. Phenolic compounds protect cultured hippocampal neurons against ethanol-withdrawal induced oxidative stress. International Journal of Molecular Sciences. 10: 1773-87. PMID 19468338 DOI: 10.3390/Ijms10041773  0.785
2009 Simpkins JW, Yi KD, Yang SH. Role of protein phosphatases and mitochondria in the neuroprotective effects of estrogens. Frontiers in Neuroendocrinology. 30: 93-105. PMID 19410596 DOI: 10.1016/J.Yfrne.2009.04.013  0.803
2009 Simpkins JW, Gatson JW, Wigginton JG. Commentary on "a roadmap for the prevention of dementia II. Leon Thal Symposium 2008." Rationale and recommendations for first evaluating anti-Alzheimer's disease medications in acute brain injury patients. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 5: 143-6. PMID 19328446 DOI: 10.1016/J.Jalz.2009.01.013  0.781
2009 Yang SH, Sarkar SN, Liu R, Perez EJ, Wang X, Wen Y, Yan LJ, Simpkins JW. Estrogen receptor beta as a mitochondrial vulnerability factor. The Journal of Biological Chemistry. 284: 9540-8. PMID 19189968 DOI: 10.1074/Jbc.M808246200  0.79
2009 Ratka A, Miller V, Brown K, Jenschke M, Simpkins J. Association of various dimensions of hot flashes with systemic levels of gonadal steroids. Experimental Biology and Medicine (Maywood, N.J.). 234: 395-402. PMID 19176867 DOI: 10.3181/0811-Rm-334  0.635
2009 Yi KD, Covey DF, Simpkins JW. Mechanism of okadaic acid-induced neuronal death and the effect of estrogens. Journal of Neurochemistry. 108: 732-40. PMID 19054278 DOI: 10.1111/J.1471-4159.2008.05805.X  0.71
2009 Jung ME, Wilson AM, Ju X, Wen Y, Metzger DB, Simpkins JW. Ethanol withdrawal provokes opening of the mitochondrial membrane permeability transition pore in an estrogen-preventable manner. The Journal of Pharmacology and Experimental Therapeutics. 328: 692-8. PMID 19050172 DOI: 10.1124/Jpet.108.146829  0.8
2008 Sarkar SN, Huang RQ, Logan SM, Yi KD, Dillon GH, Simpkins JW. Estrogens directly potentiate neuronal L-type Ca2+ channels. Proceedings of the National Academy of Sciences of the United States of America. 105: 15148-53. PMID 18815371 DOI: 10.1073/Pnas.0802379105  0.779
2008 Simpkins JW, Singh M. More than a decade of estrogen neuroprotection. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 4: S131-6. PMID 18631989 DOI: 10.1016/J.Jalz.2007.10.009  0.554
2008 Simpkins JW, Yang SH, Sarkar SN, Pearce V. Estrogen actions on mitochondria--physiological and pathological implications. Molecular and Cellular Endocrinology. 290: 51-9. PMID 18571833 DOI: 10.1016/J.Mce.2008.04.013  0.801
2008 Yi KD, Simpkins JW. Protein phosphatase 1, protein phosphatase 2A, and calcineurin play a role in estrogen-mediated neuroprotection. Endocrinology. 149: 5235-43. PMID 18566123 DOI: 10.1210/En.2008-0610  0.724
2008 Jung ME, Simpkins JW, Wilson AM, Downey HF, Mallet RT. Intermittent hypoxia conditioning prevents behavioral deficit and brain oxidative stress in ethanol-withdrawn rats. Journal of Applied Physiology (Bethesda, Md. : 1985). 105: 510-7. PMID 18499779 DOI: 10.1152/Japplphysiol.90317.2008  0.799
2008 Jung ME, Yan LJ, Forster MJ, Simpkins JW. Ethanol withdrawal provokes mitochondrial injury in an estrogen preventable manner. Journal of Bioenergetics and Biomembranes. 40: 35-44. PMID 18210193 DOI: 10.1007/S10863-008-9129-Y  0.796
2008 Yi KD, Cai ZY, Covey DF, Simpkins JW. Estrogen receptor-independent neuroprotection via protein phosphatase preservation and attenuation of persistent extracellular signal-regulated kinase 1/2 activation. The Journal of Pharmacology and Experimental Therapeutics. 324: 1188-95. PMID 18089844 DOI: 10.1124/Jpet.107.132308  0.721
2008 Prokai-Tatrai K, Perjesi P, Rivera-Portalatin NM, Simpkins JW, Prokai L. Mechanistic investigations on the antioxidant action of a neuroprotective estrogen derivative. Steroids. 73: 280-8. PMID 18068745 DOI: 10.1016/J.Steroids.2007.10.011  0.33
2008 Singh M, Sumien N, Kyser C, Simpkins JW. Estrogens and progesterone as neuroprotectants: what animal models teach us. Frontiers in Bioscience : a Journal and Virtual Library. 13: 1083-9. PMID 17981614 DOI: 10.2741/2746  0.802
2008 Sharma AB, Barlow MA, Yang SH, Simpkins JW, Mallet RT. Pyruvate enhances neurological recovery following cardiopulmonary arrest and resuscitation. Resuscitation. 76: 108-19. PMID 17618729 DOI: 10.1016/J.Resuscitation.2007.04.028  0.666
2008 Simpkins JW, Dykens JA. Mitochondrial mechanisms of estrogen neuroprotection. Brain Research Reviews. 57: 421-30. PMID 17512984 DOI: 10.1016/J.Brainresrev.2007.04.007  0.38
2008 Jung ME, Mallet RT, Fred Downey H, Wilson AM, Metzger D, Brown ND, Simpkins JW. INTERMITTENT HYPOXIA CONDITIONING PREVENTS OXIDATIVE BRAIN INJURY IN ETHANOL WITHDRAWN RATS Alcoholism: Clinical and Experimental Research. 32: 370A-370A. DOI: 10.1111/J.1530-0277.2008.00689_13.X  0.799
2008 Jung ME, Wilson AM, Metzger D, Brown ND, Simpkins JW. OVARIECTOMY SENSITIZES A DELETERIOUS INTERACTION BETWEEN ETHANOL WITHDRAWAL AND AGING TO A GREATER DEGREE AFTER ABRUPT TERMINATION THAN GRADUAL TERMINATION OF ETHANOL Alcoholism: Clinical and Experimental Research. 32: 369A-369A. DOI: 10.1111/J.1530-0277.2008.00689_12.X  0.781
2007 Xia M, Yang S, Simpkins JW, Liu H. Noninvasive monitoring of estrogen effects against ischemic stroke in rats by near-infrared spectroscopy. Applied Optics. 46: 8315-21. PMID 18059674 DOI: 10.1364/Ao.46.008315  0.681
2007 Schetz JA, Perez E, Liu R, Chen S, Lee I, Simpkins JW. A prototypical Sigma-1 receptor antagonist protects against brain ischemia. Brain Research. 1181: 1-9. PMID 17919467 DOI: 10.1016/J.Brainres.2007.08.068  0.737
2007 Tesco G, Koh YH, Kang EL, Cameron AN, Das S, Sena-Esteves M, Hiltunen M, Yang SH, Zhong Z, Shen Y, Simpkins JW, Tanzi RE. Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity. Neuron. 54: 721-37. PMID 17553422 DOI: 10.1016/J.Neuron.2007.05.012  0.665
2007 Prokai L, Simpkins JW. Structure-nongenomic neuroprotection relationship of estrogens and estrogen-derived compounds. Pharmacology & Therapeutics. 114: 1-12. PMID 17336390 DOI: 10.1016/J.Pharmthera.2007.01.006  0.332
2007 Liu R, Wang X, Liu Q, Yang SH, Simpkins JW. Dose dependence and therapeutic window for the neuroprotective effects of 17beta-estradiol when administered after cerebral ischemia. Neuroscience Letters. 415: 237-41. PMID 17331646 DOI: 10.1016/J.Neulet.2007.01.074  0.754
2007 Jung ME, Agarwal R, Simpkins JW. Ethanol withdrawal posttranslationally decreases the activity of cytochrome c oxidase in an estrogen reversible manner. Neuroscience Letters. 416: 160-4. PMID 17320290 DOI: 10.1016/J.Neulet.2007.01.065  0.797
2007 Mao X, Yang SH, Simpkins JW, Barger SW. Glutamate receptor activation evokes calpain-mediated degradation of Sp3 and Sp4, the prominent Sp-family transcription factors in neurons. Journal of Neurochemistry. 100: 1300-14. PMID 17316402 DOI: 10.1111/J.1471-4159.2006.04297.X  0.624
2007 Wen Y, Yang SH, Liu R, Perez EJ, Brun-Zinkernagel AM, Koulen P, Simpkins JW. Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats. Biochimica Et Biophysica Acta. 1772: 473-83. PMID 17113760 DOI: 10.1016/J.Bbadis.2006.10.011  0.803
2007 Jung M, Mallet R, Simpkins J, Confessore A, Wilson A, Coleman S, Downey F. Intermittent hypoxia conditioning protects against behavioral and oxidative signs of ethanol withdrawal in male rats The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A413-A  0.781
2007 Perez E, Wang X, Simpkins JW. Role of antioxidant activity of estrogens in their potent neuroprotection Oxidative Stress and Neurodegenerative Disorders. 503-524. DOI: 10.1016/B978-044452809-4/50163-0  0.688
2006 Jung ME, Wilson AM, Simpkins JW. A nonfeminizing estrogen analog protects against ethanol withdrawal toxicity in immortalized hippocampal cells. The Journal of Pharmacology and Experimental Therapeutics. 319: 543-50. PMID 16873607 DOI: 10.1124/Jpet.106.103630  0.778
2006 Bushnell CD, Hurn P, Colton C, Miller VM, del Zoppo G, Elkind MS, Stern B, Herrington D, Ford-Lynch G, Gorelick P, James A, Brown CM, Choi E, Bray P, Newby LK, ... ... Simpkins J, et al. Advancing the study of stroke in women: summary and recommendations for future research from an NINDS-Sponsored Multidisciplinary Working Group. Stroke; a Journal of Cerebral Circulation. 37: 2387-99. PMID 16857945 DOI: 10.1161/01.Str.0000236053.37695.15  0.671
2006 Yang SH, Prokai L, Simpkins JW. Correspondence regarding Schwend and Gustafsson, "False positives in MALDI-TOF detection of ERbeta in mitochondria". Biochemical and Biophysical Research Communications. 345: 917-8. PMID 16707101 DOI: 10.1016/J.Bbrc.2006.05.009  0.644
2006 Singh M, Dykens JA, Simpkins JW. Novel mechanisms for estrogen-induced neuroprotection. Experimental Biology and Medicine (Maywood, N.J.). 231: 514-21. PMID 16636299 DOI: 10.1177/153537020623100505  0.584
2006 Wang X, Dykens JA, Perez E, Liu R, Yang S, Covey DF, Simpkins JW. Neuroprotective effects of 17beta-estradiol and nonfeminizing estrogens against H2O2 toxicity in human neuroblastoma SK-N-SH cells. Molecular Pharmacology. 70: 395-404. PMID 16614138 DOI: 10.1124/Mol.106.022384  0.806
2006 Ratka A, Miller V, Brown K, Raut A, Cipher D, Meczekalski B, Simpkins JW. Menopausal Vasomotor Symptoms (MVS) survey for assessment of hot flashes. Journal of Women's Health (2002). 15: 77-89. PMID 16417422 DOI: 10.1089/Jwh.2006.15.77  0.763
2005 Rewal M, Wen Y, Wilson A, Simpkins JW, Jung ME. Role of parvalbumin in estrogen protection from ethanol withdrawal syndrome. Alcoholism, Clinical and Experimental Research. 29: 1837-44. PMID 16269913 DOI: 10.1097/01.Alc.0000183013.64829.2E  0.788
2005 Jung ME, Watson DG, Simpkins JW. Suppression of protein kinase Cepsilon mediates 17beta-estradiol-induced neuroprotection in an immortalized hippocampal cell line. Journal of Neurochemistry. 95: 745-55. PMID 16248886 DOI: 10.1111/J.1471-4159.2005.03424.X  0.797
2005 Liu R, Wen Y, Perez E, Wang X, Day AL, Simpkins JW, Yang SH. 17beta-Estradiol attenuates blood-brain barrier disruption induced by cerebral ischemia-reperfusion injury in female rats. Brain Research. 1060: 55-61. PMID 16212944 DOI: 10.1016/J.Brainres.2005.08.048  0.805
2005 He Z, Cui L, Meschia JF, Dickson DW, Brott TG, Simpkins JW, Day AL, McKinney M. Hippocampal progenitor cells express nestin following cerebral ischemia in rats. Neuroreport. 16: 1541-4. PMID 16148741 DOI: 10.1097/01.Wnr.0000179074.32035.46  0.501
2005 Wen Y, Yang S, Liu R, Simpkins JW. Cell-cycle regulators are involved in transient cerebral ischemia induced neuronal apoptosis in female rats. Febs Letters. 579: 4591-9. PMID 16098510 DOI: 10.1016/J.Febslet.2005.07.028  0.751
2005 Yi KD, Chung J, Pang P, Simpkins JW. Role of protein phosphatases in estrogen-mediated neuroprotection. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 7191-8. PMID 16079401 DOI: 10.1523/Jneurosci.1328-05.2005  0.795
2005 Simpkins JW, Wen Y, Perez E, Yang S, Wang X. Role of nonfeminizing estrogens in brain protection from cerebral ischemia: an animal model of Alzheimer's disease neuropathology. Annals of the New York Academy of Sciences. 1052: 233-42. PMID 16024766 DOI: 10.1196/Annals.1347.019  0.814
2005 Jung ME, Jacobs S, Rewal M, Wilson A, Simpkins JW. Estradiol protects against alteration of protein kinase C(epsilon) in a binge model of ethanol dependence and withdrawal. European Journal of Pharmacology. 515: 62-72. PMID 15894303 DOI: 10.1016/J.Ejphar.2005.03.038  0.771
2005 Yang SH, Liu R, Perez EJ, Wang X, Simpkins JW. Estrogens as protectants of the neurovascular unit against ischemic stroke. Current Drug Targets. Cns and Neurological Disorders. 4: 169-77. PMID 15857302 DOI: 10.2174/1568007053544174  0.816
2005 Kumar DM, Perez E, Cai ZY, Aoun P, Brun-Zinkernagel AM, Covey DF, Simpkins JW, Agarwal N. Role of nonfeminizing estrogen analogues in neuroprotection of rat retinal ganglion cells against glutamate-induced cytotoxicity. Free Radical Biology & Medicine. 38: 1152-63. PMID 15808412 DOI: 10.1016/J.Freeradbiomed.2004.12.007  0.796
2005 Perez E, Liu R, Yang SH, Cai ZY, Covey DF, Simpkins JW. Neuroprotective effects of an estratriene analog are estrogen receptor independent in vitro and in vivo. Brain Research. 1038: 216-22. PMID 15757637 DOI: 10.1016/J.Brainres.2005.01.026  0.812
2005 Simpkins JW, Wang J, Wang X, Perez E, Prokai L, Dykens JA. Mitochondria play a central role in estrogen-induced neuroprotection. Current Drug Targets. Cns and Neurological Disorders. 4: 69-83. PMID 15723615 DOI: 10.2174/1568007053005073  0.74
2005 Simpkins JW, Yang SH, Wen Y, Singh M. Estrogens, progestins, menopause and neurodegeneration: basic and clinical studies. Cellular and Molecular Life Sciences : Cmls. 62: 271-80. PMID 15723163 DOI: 10.1007/S00018-004-4382-2  0.753
2005 Rewal M, Wen Y, Simpkins JW, Jung ME. Ethanol withdrawal reduces cerebellar parvalbumin expression in a manner reversed by estrogens. Neuroscience Letters. 377: 44-8. PMID 15722185 DOI: 10.1016/J.Neulet.2004.11.067  0.784
2005 Jung ME, Gatch MB, Simpkins JW. Estrogen neuroprotection against the neurotoxic effects of ethanol withdrawal: potential mechanisms. Experimental Biology and Medicine (Maywood, N.J.). 230: 8-22. PMID 15618121 DOI: 10.1177/153537020523000102  0.801
2005 Yang SH, Liu R, Wen Y, Perez E, Cutright J, Brun-Zinkernagel AM, Singh M, Day AL, Simpkins JW. Neuroendocrine mechanism for tolerance to cerebral ischemia-reperfusion injury in male rats. Journal of Neurobiology. 62: 341-51. PMID 15514992 DOI: 10.1002/Neu.20103  0.795
2005 Singh M, Simpkins JW. The future of hormone therapy: What basic science and clinical studies teach us - Summary Annals of the New York Academy of Sciences. 1052: 259-260. DOI: 10.1196/Annals.1347.027  0.475
2005 Singh M, Simpkins JW. The future of hormone therapy: What basic science and clinical studies teach us - Introduction Annals of the New York Academy of Sciences. 1052: ix-x. DOI: 10.1196/Annals.1347.021  0.474
2005 Kumar DM, Perez E, Cai ZY, Aoun P, Brun-Zinkernagel A, Covey DF, Simpkins JW, Agarwal N. Corrigendum to “Role of nonfeminizing estrogen analogues in neuroprotection of rat retinal ganglion cells against glutamate-induced cytotoxicity” [Free Radic. Biol. Med. 38:1152–1163; 2005] Free Radical Biology and Medicine. 39: 1676. DOI: 10.1016/J.Freeradbiomed.2005.09.009  0.784
2005 Prokai L, Prokai-Tatrai K, Perjési P, Simpkins JW. Mechanistic insights into the direct antioxidant effects of estrogens Drug Development Research. 66: 118-125. DOI: 10.1002/Ddr.20050  0.312
2005 Perez E, Cai ZY, Covey DF, Simpkins JW. Neuroprotective effects of estratriene analogs: Structure-activity relationships and molecular optimization Drug Development Research. 66: 78-92. DOI: 10.1002/Ddr.20047  0.681
2004 He Z, Cui L, Wu SS, Li XY, Simpkins JW, McKinney M, Day AL. Increased severity of acute cerebral ischemic injury correlates with enhanced stem cell induction as well as with predictive behavioral profiling. Current Neurovascular Research. 1: 399-409. PMID 16181088 DOI: 10.2174/1567202043361893  0.506
2004 Simpkins JW, Singh M. Consortium for the Assessment of Research on Progestins and Estrogens (CARPE) Fort Worth, Texas August 1-3, 2003. Journal of Women's Health (2002). 13: 1165-8. PMID 15650349 DOI: 10.1089/Jwh.2004.13.1165  0.489
2004 Rewal M, Jung ME, Simpkins JW. Role of the GABA-A system in estrogen-induced protection against brain lipid peroxidation in ethanol-withdrawn rats. Alcoholism, Clinical and Experimental Research. 28: 1907-15. PMID 15608608 DOI: 10.1097/01.Alc.0000148100.78628.E7  0.799
2004 Jung ME, Rewal M, Perez E, Wen Y, Simpkins JW. Estrogen protects against brain lipid peroxidation in ethanol-withdrawn rats. Pharmacology, Biochemistry, and Behavior. 79: 573-86. PMID 15582030 DOI: 10.1016/J.Pbb.2004.09.007  0.792
2004 Simpkins JW, Yang SH, Liu R, Perez E, Cai ZY, Covey DF, Green PS. Estrogen-like compounds for ischemic neuroprotection. Stroke; a Journal of Cerebral Circulation. 35: 2648-51. PMID 15472107 DOI: 10.1161/01.Str.0000143734.59507.88  0.808
2004 Wen Y, Yang S, Liu R, Simpkins JW. Transient cerebral ischemia induces site-specific hyperphosphorylation of tau protein. Brain Research. 1022: 30-8. PMID 15353210 DOI: 10.1016/J.Brainres.2004.05.106  0.752
2004 Wen Y, Perez EJ, Green PS, Sarkar SN, Simpkins JW. nNOS is involved in estrogen mediated neuroprotection in neuroblastoma cells. Neuroreport. 15: 1515-8. PMID 15194886 DOI: 10.1097/01.Wnr.0000131674.92694.96  0.799
2004 Wen Y, Yang S, Liu R, Perez E, Yi KD, Koulen P, Simpkins JW. Estrogen attenuates nuclear factor-kappa B activation induced by transient cerebral ischemia. Brain Research. 1008: 147-54. PMID 15145751 DOI: 10.1016/J.Brainres.2004.02.019  0.814
2004 Wen Y, Onyewuchi O, Yang S, Liu R, Simpkins JW. Increased beta-secretase activity and expression in rats following transient cerebral ischemia. Brain Research. 1009: 1-8. PMID 15120577 DOI: 10.1016/J.Brainres.2003.09.086  0.762
2004 Cammarata PR, Chu S, Moor A, Wang Z, Yang SH, Simpkins JW. Subcellular distribution of native estrogen receptor alpha and beta subtypes in cultured human lens epithelial cells. Experimental Eye Research. 78: 861-71. PMID 15037120 DOI: 10.1016/J.Exer.2003.09.027  0.655
2004 Yang SH, Liu R, Perez EJ, Wen Y, Stevens SM, Valencia T, Brun-Zinkernagel AM, Prokai L, Will Y, Dykens J, Koulen P, Simpkins JW. Mitochondrial localization of estrogen receptor beta. Proceedings of the National Academy of Sciences of the United States of America. 101: 4130-5. PMID 15024130 DOI: 10.1073/Pnas.0306948101  0.795
2004 Wen Y, Yang S, Liu R, Brun-Zinkernagel AM, Koulen P, Simpkins JW. Transient cerebral ischemia induces aberrant neuronal cell cycle re-entry and Alzheimer's disease-like tauopathy in female rats. The Journal of Biological Chemistry. 279: 22684-92. PMID 14982935 DOI: 10.1074/Jbc.M311768200  0.811
2003 Yang SH, Liu R, Wu SS, Simpkins JW. The use of estrogens and related compounds in the treatment of damage from cerebral ischemia. Annals of the New York Academy of Sciences. 1007: 101-7. PMID 14993044 DOI: 10.1196/Annals.1286.010  0.733
2003 Fan T, Yang SH, Johnson E, Osteen B, Hayes R, Day AL, Simpkins JW. 17beta-Estradiol extends ischemic thresholds and exerts neuroprotective effects in cerebral subcortex against transient focal cerebral ischemia in rats. Brain Research. 993: 10-7. PMID 14642826 DOI: 10.1016/J.Brainres.2003.07.006  0.751
2003 Rewal M, Jung ME, Wen Y, Brun-Zinkernagel AM, Simpkins JW. Role of the GABAA system in behavioral, motoric, and cerebellar protection by estrogen during ethanol withdrawal. Alcohol (Fayetteville, N.Y.). 31: 49-61. PMID 14615011 DOI: 10.1016/J.Alcohol.2003.07.005  0.793
2003 Jung ME, Watson DG, Wen Y, Simpkins JW. Role of protein kinase C in estrogen protection against apoptotic cerebellar cell death in ethanol-withdrawn rats. Alcohol (Fayetteville, N.Y.). 31: 39-48. PMID 14615010 DOI: 10.1016/J.Alcohol.2003.07.004  0.797
2003 Prokai L, Prokai-Tatrai K, Perjesi P, Zharikova AD, Perez EJ, Liu R, Simpkins JW. Quinol-based cyclic antioxidant mechanism in estrogen neuroprotection. Proceedings of the National Academy of Sciences of the United States of America. 100: 11741-6. PMID 14504383 DOI: 10.1073/Pnas.2032621100  0.731
2003 Aoun P, Watson DG, Simpkins JW. Neuroprotective effects of PPARgamma agonists against oxidative insults in HT-22 cells. European Journal of Pharmacology. 472: 65-71. PMID 12860474 DOI: 10.1016/S0014-2999(03)01867-3  0.785
2003 Kaja S, Yang SH, Wei J, Fujitani K, Liu R, Brun-Zinkernagel AM, Simpkins JW, Inokuchi K, Koulen P. Estrogen protects the inner retina from apoptosis and ischemia-induced loss of Vesl-1L/Homer 1c immunoreactive synaptic connections. Investigative Ophthalmology & Visual Science. 44: 3155-62. PMID 12824266 DOI: 10.1167/Iovs.02-1204  0.786
2003 Aoun P, Simpkins JW, Agarwal N. Role of PPAR-gamma ligands in neuroprotection against glutamate-induced cytotoxicity in retinal ganglion cells. Investigative Ophthalmology & Visual Science. 44: 2999-3004. PMID 12824244 DOI: 10.1167/Iovs.02-1060  0.783
2003 Wang X, Simpkins JW, Dykens JA, Cammarata PR. Oxidative damage to human lens epithelial cells in culture: estrogen protection of mitochondrial potential, ATP, and cell viability. Investigative Ophthalmology & Visual Science. 44: 2067-75. PMID 12714645 DOI: 10.1167/Iovs.02-0841  0.466
2003 Dykens JA, Simpkins JW, Wang J, Gordon K. Polycyclic phenols, estrogens and neuroprotection: a proposed mitochondrial mechanism. Experimental Gerontology. 38: 101-7. PMID 12543267 DOI: 10.1016/S0531-5565(02)00162-6  0.355
2002 Liu R, Yang SH, Perez E, Yi KD, Wu SS, Eberst K, Prokai L, Prokai-Tatrai K, Cai ZY, Covey DF, Day AL, Simpkins JW. Neuroprotective effects of a novel non-receptor-binding estrogen analogue: in vitro and in vivo analysis. Stroke; a Journal of Cerebral Circulation. 33: 2485-91. PMID 12364742 DOI: 10.1161/01.Str.0000030317.43597.C8  0.811
2002 Jung ME, Yang SH, Brun-Zinkernagel AM, Simpkins JW. Estradiol protects against cerebellar damage and motor deficit in ethanol-withdrawn rats. Alcohol (Fayetteville, N.Y.). 26: 83-93. PMID 12007583 DOI: 10.1016/S0741-8329(01)00199-9  0.785
2002 Zheng H, Xu H, Uljon SN, Gross R, Hardy K, Gaynor J, Lafrancois J, Simpkins J, Refolo LM, Petanceska S, Wang R, Duff K. Modulation of A(beta) peptides by estrogen in mouse models. Journal of Neurochemistry. 80: 191-6. PMID 11796757 DOI: 10.1046/J.0022-3042.2001.00690.X  0.317
2002 He Z, He YJ, Day AL, Simpkins JW. Proestrus levels of estradiol during transient global cerebral ischemia improves the histological outcome of the hippocampal CA1 region: perfusion-dependent and-independent mechanisms. Journal of the Neurological Sciences. 193: 79-87. PMID 11790387 DOI: 10.1016/S0022-510X(01)00648-7  0.535
2002 Yang SH, Perez E, Cutright J, Liu R, He Z, Day AL, Simpkins JW. Testosterone increases neurotoxicity of glutamate in vitro and ischemia-reperfusion injury in an animal model. Journal of Applied Physiology (Bethesda, Md. : 1985). 92: 195-201. PMID 11744660 DOI: 10.1152/Jappl.2002.92.1.195  0.804
2001 Wang J, Green PS, Simpkins JW. Estradiol protects against ATP depletion, mitochondrial membrane potential decline and the generation of reactive oxygen species induced by 3-nitroproprionic acid in SK-N-SH human neuroblastoma cells. Journal of Neurochemistry. 77: 804-11. PMID 11331409 DOI: 10.1046/J.1471-4159.2001.00271.X  0.68
2001 Shi J, Bui JD, Yang SH, He Z, Lucas TH, Buckley DL, Blackband SJ, King MA, Day AL, Simpkins JW. Estrogens decrease reperfusion-associated cortical ischemic damage: an MRI analysis in a transient focal ischemia model. Stroke; a Journal of Cerebral Circulation. 32: 987-92. PMID 11283401 DOI: 10.1161/01.Str.32.4.987  0.675
2001 Yang SH, He Z, Wu SS, He YJ, Cutright J, Millard WJ, Day AL, Simpkins JW. 17-beta estradiol can reduce secondary ischemic damage and mortality of subarachnoid hemorrhage. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 21: 174-81. PMID 11176283 DOI: 10.1097/00004647-200102000-00009  0.8
2001 Green PS, Yang SH, Nilsson KR, Kumar AS, Covey DF, Simpkins JW. The nonfeminizing enantiomer of 17beta-estradiol exerts protective effects in neuronal cultures and a rat model of cerebral ischemia. Endocrinology. 142: 400-6. PMID 11145603 DOI: 10.1210/Endo.142.1.7888  0.695
2000 Green PS, Perez EJ, Calloway T, Simpkins JW. Estradiol attenuation of beta-amyloid-induced toxicity: a comparison o. Journal of Neurocytology. 29: 419-23. PMID 11424958 DOI: 10.1023/A:1007173509470  0.782
2000 Green PS, Simpkins JW. Estrogens and estrogen-like non-feminizing compounds. Their role in the prevention and treatment of Alzheimer's disease. Annals of the New York Academy of Sciences. 924: 93-8. PMID 11193809 DOI: 10.1111/J.1749-6632.2000.Tb05566.X  0.664
2000 He Z, Yang SH, Naritomi H, Yamawaki T, Liu Q, King MA, Day AL, Simpkins JW. Definition of the anterior choroidal artery territory in rats using intraluminal occluding technique. Journal of the Neurological Sciences. 182: 16-28. PMID 11102635 DOI: 10.1016/S0022-510X(00)00434-2  0.64
2000 Green PS, Yang SH, Simpkins JW. Neuroprotective effects of phenolic A ring oestrogens. Novartis Foundation Symposium. 230: 202-13; discussion 2. PMID 10965510 DOI: 10.1002/0470870818.Ch15  0.761
2000 Green PS, Simpkins JW. Neuroprotective effects of estrogens: potential mechanisms of action. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 18: 347-58. PMID 10817919 DOI: 10.1016/S0736-5748(00)00017-4  0.694
2000 Yang SH, Shi J, Day AL, Simpkins JW. Estradiol exerts neuroprotective effects when administered after ischemic insult. Stroke; a Journal of Cerebral Circulation. 31: 745-9; discussion 74. PMID 10700514 DOI: 10.1161/01.Str.31.3.745  0.598
2000 Persky AM, Green PS, Stubley L, Howell CO, Zaulyanov L, Brazeau GA, Simpkins JW. Protective effect of estrogens against oxidative damage to heart and skeletal muscle in vivo and in vitro. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 223: 59-66. PMID 10632962 DOI: 10.1046/J.1525-1373.2000.22308.X  0.788
2000 Shi J, Yang SH, Stubley L, Day AL, Simpkins JW. Hypoperfusion induces overexpression of beta-amyloid precursor protein mRNA in a focal ischemic rodent model. Brain Research. 853: 1-4. PMID 10627301 DOI: 10.1016/S0006-8993(99)02113-7  0.801
1999 He Z, Yamawaki T, Yang S, Day AL, Simpkins JW, Naritomi H. Experimental model of small deep infarcts involving the hypothalamus in rats: changes in body temperature and postural reflex. Stroke; a Journal of Cerebral Circulation. 30: 2743-51; discussion . PMID 10583006 DOI: 10.1161/01.Str.30.12.2743  0.713
1999 Eldridge JC, Wetzel LT, Stevens JT, Simpkins JW. The mammary tumor response in triazine-treated female rats: a threshold-mediated interaction with strain and species-specific reproductive senescence. Steroids. 64: 672-8. PMID 10503727 DOI: 10.1016/S0039-128X(99)00051-3  0.315
1999 Zaulyanov LL, Green PS, Simpkins JW. Glutamate receptor requirement for neuronal death from anoxia-reoxygenation: an in Vitro model for assessment of the neuroprotective effects of estrogens. Cellular and Molecular Neurobiology. 19: 705-18. PMID 10456232 DOI: 10.1023/A:1006948921855  0.664
1998 Shi J, Panickar KS, Yang SH, Rabbani O, Day AL, Simpkins JW. Estrogen attenuates over-expression of beta-amyloid precursor protein messager RNA in an animal model of focal ischemia. Brain Research. 810: 87-92. PMID 9813255 DOI: 10.1016/S0006-8993(98)00888-9  0.809
1998 Gridley KE, Green PS, Simpkins JW. A novel, synergistic interaction between 17 beta-estradiol and glutathione in the protection of neurons against beta-amyloid 25-35-induced toxicity in vitro. Molecular Pharmacology. 54: 874-80. PMID 9804622 DOI: 10.1124/Mol.54.5.874  0.664
1998 Simpkins JW, Rabbani O, Shi J, Panickar KS, Green PS, Day AL. A system for the brain-enhanced delivery of estradiol: an assessment of its potential for the treatment of Alzheimer's disease and stroke. Die Pharmazie. 53: 505-11. PMID 9741059  0.797
1998 Hawk T, Zhang YQ, Rajakumar G, Day AL, Simpkins JW. Testosterone increases and estradiol decreases middle cerebral artery occlusion lesion size in male rats. Brain Research. 796: 296-8. PMID 9689481 DOI: 10.1016/S0006-8993(98)00327-8  0.807
1998 Green PS, Gridley KE, Simpkins JW. Nuclear estrogen receptor-independent neuroprotection by estratrienes: a novel interaction with glutathione. Neuroscience. 84: 7-10. PMID 9522357 DOI: 10.1016/S0306-4522(97)00595-2  0.678
1998 Zhang YQ, Shi J, Rajakumar G, Day AL, Simpkins JW. Effects of gender and estradiol treatment on focal brain ischemia. Brain Research. 784: 321-4. PMID 9518671 DOI: 10.1016/S0006-8993(97)00502-7  0.801
1998 Panickar KS, Purushotham K, King MA, Rajakumar G, Simpkins JW. Hypoglycemia-induced seizures reduce cyclic AMP response element binding protein levels in the rat hippocampus. Neuroscience. 83: 1155-60. PMID 9502254 DOI: 10.1016/S0306-4522(97)00466-1  0.783
1997 Gridley KE, Green PS, Simpkins JW. Low concentrations of estradiol reduce beta-amyloid (25-35)-induced toxicity, lipid peroxidation and glucose utilization in human SK-N-SH neuroblastoma cells. Brain Research. 778: 158-65. PMID 9462888 DOI: 10.1016/S0006-8993(97)01056-1  0.653
1997 Green PS, Gordon K, Simpkins JW. Phenolic A ring requirement for the neuroprotective effects of steroids. The Journal of Steroid Biochemistry and Molecular Biology. 63: 229-35. PMID 9459189 DOI: 10.1016/S0960-0760(97)00124-6  0.655
1997 Shi J, Zhang YQ, Simpkins JW. Effects of 17beta-estradiol on glucose transporter 1 expression and endothelial cell survival following focal ischemia in the rats. Experimental Brain Research. 117: 200-6. PMID 9419067 DOI: 10.1007/s002210050216  0.692
1997 Panickar KS, Guan G, King MA, Rajakumar G, Simpkins JW. 17beta-estradiol attenuates CREB decline in the rat hippocampus following seizure. Journal of Neurobiology. 33: 961-7. PMID 9407016 DOI: 10.1002/(Sici)1097-4695(199712)33:7<961::Aid-Neu7>3.0.Co;2-6  0.8
1997 Shi J, Xiang Y, Simpkins JW. Hypoglycemia enhances the expression of mRNA encoding beta-amyloid precursor protein in rat primary cortical astroglial cells. Brain Research. 772: 247-51. PMID 9406980 DOI: 10.1016/S0006-8993(97)00827-5  0.675
1997 Simpkins JW, Rajakumar G, Zhang YQ, Simpkins CE, Greenwald D, Yu CJ, Bodor N, Day AL. Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat. Journal of Neurosurgery. 87: 724-30. PMID 9347981 DOI: 10.3171/Jns.1997.87.5.0724  0.809
1997 Simpkins JW, Green PS, Gridley KE, Singh M, de Fiebre NC, Rajakumar G. Role of estrogen replacement therapy in memory enhancement and the prevention of neuronal loss associated with Alzheimer's disease. The American Journal of Medicine. 103: 19S-25S. PMID 9344403 DOI: 10.1016/S0002-9343(97)00260-X  0.806
1997 Rabbani O, Panickar KS, Rajakumar G, King MA, Bodor N, Meyer EM, Simpkins JW. 17 beta-estradiol attenuates fimbrial lesion-induced decline of ChAT-immunoreactive neurons in the rat medial septum. Experimental Neurology. 146: 179-86. PMID 9225751 DOI: 10.1006/Exnr.1997.6516  0.794
1997 Ratka A, Simpkins JW. Luteinizing hormone-releasing hormone (LHRH) attenuates morphine-induced inhibition of cyclic AMP (cAMP) in opioid-responsive SK-N-SH cells. Neuropeptides. 31: 113-7. PMID 9179862 DOI: 10.1016/S0143-4179(97)90078-0  0.64
1997 Kourounakis A, Bodor N, Simpkins J. Synthesis and evaluation of brain-targeted chemical delivery systems for the neurotrophomodulator 4-methylcatechol. The Journal of Pharmacy and Pharmacology. 49: 1-9. PMID 9120757 DOI: 10.1111/J.2042-7158.1997.Tb06742.X  0.309
1997 Green PS, Bishop J, Simpkins JW. 17α-Estradiol Exerts Neuroprotective Effects on SK-N-SH Cells The Journal of Neuroscience. 17: 511-515. DOI: 10.1523/Jneurosci.17-02-00511.1997  0.656
1996 Green PS, Gridley KE, Simpkins JW. Estradiol protects against beta-amyloid (25-35)-induced toxicity in SK-N-SH human neuroblastoma cells. Neuroscience Letters. 218: 165-8. PMID 8945754 DOI: 10.1016/S0304-3940(96)13148-7  0.64
1995 Singh M, Meyer EM, Simpkins JW. The effect of ovariectomy and estradiol replacement on brain-derived neurotrophic factor messenger ribonucleic acid expression in cortical and hippocampal brain regions of female Sprague-Dawley rats. Endocrinology. 136: 2320-4. PMID 7720680 DOI: 10.1210/Endo.136.5.7720680  0.55
1994 Singh M, Meyer EM, Millard WJ, Simpkins JW. Ovarian steroid deprivation results in a reversible learning impairment and compromised cholinergic function in female Sprague-Dawley rats. Brain Research. 644: 305-12. PMID 8050041 DOI: 10.1016/0006-8993(94)91694-2  0.695
1994 Bishop J, Simpkins JW. Estradiol treatment increases viability of glioma and neuroblastoma cells in vitro. Molecular and Cellular Neurosciences. 5: 303-8. PMID 7804599 DOI: 10.1006/Mcne.1994.1036  0.311
1994 Simpkins JW, Singh M, Bishop J. The potential role for estrogen replacement therapy in the treatment of the cognitive decline and neurodegeneration associated with Alzheimer's disease. Neurobiology of Aging. 15: S195-7. PMID 7700453 DOI: 10.1016/0197-4580(94)90205-4  0.51
1993 Simpkins JW, Millard WJ, Berglund LA. Effects of chronic stimulation or antagonism of opiate receptors on GH secretion in male and female rats. Life Sciences. 52: 1443-50. PMID 8385257 DOI: 10.1016/0024-3205(93)90068-E  0.783
1992 Singh M, Simpkins JW, Layden MP, Romano TM, Millard WJ. Opiate modulation of growth hormone secretion is compromised during the steroid-induced luteinizing hormone surge. Neuroendocrinology. 55: 214-20. PMID 1620289 DOI: 10.1159/000126117  0.687
1992 Singh M, Millard WJ, Layden MP, Romano TM, Simpkins JW. Opiate stimulation of prolactin secretion is reversed by ovarian hormone treatment. Neuroendocrinology. 56: 195-203. PMID 1407373 DOI: 10.1159/000126228  0.687
1991 Ratka A, Simpkins JW. Effects of estradiol and progesterone on the sensitivity to pain and on morphine-induced antinociception in female rats. Hormones and Behavior. 25: 217-28. PMID 2066081 DOI: 10.1016/0018-506X(91)90052-J  0.674
1991 Berglund LA, Simpkins JW. Luteinizing hormone-releasing hormone alters the hypothalamic effects of morphine in the rat. Endocrinology. 128: 2799-804. PMID 2036964 DOI: 10.1210/Endo-128-6-2799  0.783
1991 Rahimy MH, Bodor N, Simpkins JW. Effects of a brain-enhanced estrogen delivery system on tail-skin temperature of the rat: implications for menopausal hot flush. Maturitas. 13: 51-63. PMID 1907349 DOI: 10.1016/0378-5122(91)90285-X  0.316
1991 Anderson WR, Rahimy MH, Brewster ME, Bodor N, Simpkins JW. The effects of a brain-enhanced estradiol delivery system on testosterone and androgen-dependent tissues. II. The role of testosterone. Endocrinology. 129: 726-33. PMID 1855470 DOI: 10.1210/Endo-129-2-726  0.708
1991 Rahimy MH, Anderson WR, Brewster ME, Bodor N, Simpkins JW. The effects of a brain-enhanced estradiol delivery system on testosterone and androgen-dependent tissues. I. Dose-response and time-course evaluation. Endocrinology. 129: 717-25. PMID 1855469 DOI: 10.1210/Endo-129-2-717  0.713
1991 Ganesan R, Romano T, Simpkins JW. Comparison of morphine tolerance in body temperature and luteinizing hormone secretion. Physiology & Behavior. 50: 505-9. PMID 1801002 DOI: 10.1016/0031-9384(91)90537-X  0.776
1991 Ganesan R, Simpkins JW. Conditioned taste aversion induced by estradiol pellets. Physiology & Behavior. 50: 849-52. PMID 1775562 DOI: 10.1016/0031-9384(91)90029-N  0.779
1991 Ratka A, Hochhaus G, Wissler RN, Simpkins JW. cAMP accumulation in opioid-sensitive SH-SY5Y neuroblastoma cells is modified by estradiol and progesterone. Molecular and Cellular Endocrinology. 78: 155-62. PMID 1663875 DOI: 10.1016/0303-7207(91)90118-C  0.666
1991 Simpkins JW, Swager D, Millard WJ. Evaluation of the sites of opioid influence on anterior pituitary hormone secretion using a quaternary opiate antagonist. Neuroendocrinology. 54: 384-90. PMID 1661859 DOI: 10.1159/000125918  0.594
1990 Simpkins JW, Andreadis DK, Millard WJ, Katovich MJ. The effect of cellular glucoprivation on skin temperature regulation in the rat. Life Sciences. 47: 107-15. PMID 2388522 DOI: 10.1016/0024-3205(90)90223-E  0.698
1990 Ratka A, Simpkins JW. Dose-dependent effects of chronic treatment with estradiol or progesterone on LH secretion in ovariectomized rats. Endocrine Research. 16: 165-84. PMID 2344834 DOI: 10.1080/07435809009032997  0.662
1990 Rahimy MH, Simpkins JW, Bodor N. Dose and time-course evaluation of a redox-based estradiol-chemical delivery system for the brain. II. Pharmacodynamic responses. Pharmaceutical Research. 7: 1107-12. PMID 2293207 DOI: 10.1023/A:1015967906433  0.307
1990 Millard WJ, Romano TM, Bodor N, Simpkins JW. Growth hormone (GH) secretory dynamics in animals administered estradiol utilizing a chemical delivery system. Pharmaceutical Research. 7: 1011-8. PMID 2281029 DOI: 10.1023/A:1015982815094  0.597
1990 Simpkins JW, Katovich MJ, Millard WJ. Glucose modulation of skin temperature responses during morphine withdrawal in the rat. Psychopharmacology. 102: 213-20. PMID 2274603 DOI: 10.1007/Bf02245924  0.679
1990 Ratka A, Simpkins JW. A modulatory role for luteinizing hormone-releasing hormone in nociceptive responses of female rats. Endocrinology. 127: 667-73. PMID 2197079 DOI: 10.1210/Endo-127-2-667  0.667
1990 Berglund LA, Millard WJ, Gabriel SM, Simpkins JW. Opiate-thyroid hormone interactions in the regulation of thyrotropin secretion in the rat. Neuroendocrinology. 52: 303-8. PMID 2120610 DOI: 10.1159/000125602  0.779
1990 Millard WJ, Romano TM, Simpkins JW. Growth hormone and thyrotropin secretory profiles and provocative testing in aged rats. Neurobiology of Aging. 11: 229-35. PMID 2113997 DOI: 10.1016/0197-4580(90)90550-J  0.594
1990 Ganesan R, Simpkins JW. The role of conditioned taste aversion in the suppression of food intake by estradiol. Physiology & Behavior. 48: 647-52. PMID 2082364 DOI: 10.1016/0031-9384(90)90205-I  0.778
1990 Simpkins JW, Katovich MJ. Hypoglycemia causes hot flashes in animal models Annals of the New York Academy of Sciences. 592: 436-437. DOI: 10.1111/J.1749-6632.1990.Tb30365.X  0.517
1990 Katovich MJ, Simpkins JW. Effect of hyperglycemia on the development of a flush response in an animal model for the menopausal hot flash Annals of the New York Academy of Sciences. 592: 433-435. DOI: 10.1111/J.1749-6632.1990.Tb30364.X  0.526
1989 Simpkins JW, Anderson WR, Dawson R, Bodor N. Effects of a brain-enhanced chemical delivery system for estradiol on body weight and food intake in intact and ovariectomized rats. Pharmaceutical Research. 6: 592-600. PMID 2798308 DOI: 10.1023/A:1015953431333  0.707
1989 Katovich MJ, Simpkins JW, O'Meara J. Effects of acute central LH-RH administration of the skin temperature response in morphine dependent rats. Brain Research. 494: 85-94. PMID 2670064 DOI: 10.1016/0006-8993(89)90146-7  0.558
1989 Anderson WR, Simpkins JW, Brewster ME, Bodor NS. Evidence for prolonged suppression of stress-induced release of adrenocorticotropic hormone and corticosterone with a brain-enhanced dexamethasone-redox delivery system. Neuroendocrinology. 50: 9-16. PMID 2547177 DOI: 10.1159/000125196  0.712
1989 Berglund LA, Millington WR, Simpkins JW. Gonadal steroid and chronic morphine treatment do not change the posttranslational processing of beta-endorphin in the rat brain. Life Sciences. 44: 591-601. PMID 2522578 DOI: 10.1016/0024-3205(89)90191-4  0.765
1988 Anderson WR, Simpkins JW, Brewster ME, Bodor N. Evidence for suppression of serum LH without elevation in serum estradiol or prolactin with a brain-enhanced redox delivery system for estradiol. Life Sciences. 42: 1493-502. PMID 3352462 DOI: 10.1016/0024-3205(88)90005-7  0.717
1988 Simpkins JW, Anderson WR, Dawson R, Seth A, Brewster M, Estes KS, Bodor N. Chronic weight loss in lean and obese rats with a brain-enhanced chemical delivery system for estradiol. Physiology & Behavior. 44: 573-80. PMID 3237846 DOI: 10.1016/0031-9384(88)90321-6  0.705
1988 Anderson WR, Simpkins JW, Brewster ME, Bodor N. Effects of a brain-enhanced chemical delivery system for estradiol on body weight and serum hormones in middle-aged male rats. Endocrine Research. 14: 131-48. PMID 3168954 DOI: 10.3109/07435808809032982  0.726
1988 Berglund LA, Derendorf H, Simpkins JW. Desensitization of brain opiate receptor mechanisms by gonadal steroid treatments that stimulate luteinizing hormone secretion. Endocrinology. 122: 2718-26. PMID 2836173 DOI: 10.1210/Endo-122-6-2718  0.762
1987 Simpkins JW, Katovich MJ. Role of hypothermia in the pentobarbital-induced blockade of luteinizing hormone secretion in female rats. Neuroendocrinology. 46: 217-21. PMID 3658110 DOI: 10.1159/000124822  0.583
1987 Katovich MJ, Simpkins JW, Song IC, O'Meara J. Effects of central application of naloxone on the skin temperature response in morphine-dependent rats. Brain Research Bulletin. 19: 81-5. PMID 3651842 DOI: 10.1016/0361-9230(87)90169-9  0.635
1987 Anderson WR, Simpkins JW, Brewster ME, Bodor N. Evidence for the reestablishment of copulatory behavior in castrated male rats with a brain-enhanced estradiol-chemical delivery system. Pharmacology, Biochemistry, and Behavior. 27: 265-71. PMID 3628441 DOI: 10.1016/0091-3057(87)90569-7  0.721
1987 Estes KS, Brewster ME, Simpkins JW, Bodor N. A novel redox system for CNS-directed delivery of estradiol causes sustained LH suppression in castrate rats. Life Sciences. 40: 1327-34. PMID 3561153 DOI: 10.1016/0024-3205(87)90590-X  0.331
1987 Gabriel SM, Berglund LA, Simpkins JW. Chronic morphine treatment enhances the negative and positive feedback effects of estradiol on gonadotropin secretion in ovariectomized rats. Endocrinology. 120: 1799-805. PMID 3032570 DOI: 10.1210/Endo-120-5-1799  0.782
1987 Simpkins JW, Millard WJ. Influence of age on neurotransmitter function. Endocrinology and Metabolism Clinics of North America. 16: 893-917. PMID 2892672 DOI: 10.1016/S0889-8529(18)30450-X  0.584
1987 Anderson WR, Simpkins JW, Woodard PA, Winwood D, Stern WC, Bodor N. Anxiolytic activity of a brain delivery system for GABA. Psychopharmacology. 92: 157-63. PMID 2885884 DOI: 10.1007/Bf00177908  0.703
1987 Katovich MJ, Simpkins JW, Barney CC. Alpha-adrenergic mediation of the tail skin temperature response to naloxone in morphine-dependent rats. Brain Research. 426: 55-61. PMID 2825916 DOI: 10.1016/0006-8993(87)90424-0  0.547
1986 Katovich MJ, Simpkins JW, O'Meara J. Effects of opioid antagonists and their quaternary analogs on temperature changes in morphine-dependent rats. Life Sciences. 39: 1845-54. PMID 3773644 DOI: 10.1016/0024-3205(86)90294-8  0.524
1986 Katovich MJ, Simpkins JW, Berglund LA, O'Meara J. Regional skin temperature changes in a rat model for the menopausal hot flush. Maturitas. 8: 67-76. PMID 3702763 DOI: 10.1016/0378-5122(86)90009-5  0.774
1986 Gabriel SM, Berglund LA, Simpkins JW. A decline in endogenous opioid influence during the steroid-induced hypersecretion of luteinizing hormone in the rat. Endocrinology. 118: 558-61. PMID 3510853 DOI: 10.1210/Endo-118-2-558  0.784
1986 Gabriel SM, Berglund LA, Kalra SP, Kalra PS, Simpkins JW. The influence of chronic morphine treatment on the negative feedback regulation of gonadotropin secretion by gonadal steroids. Endocrinology. 119: 2762-7. PMID 3096696 DOI: 10.1210/Endo-119-6-2762  0.778
1985 Gabriel SM, Simpkins JW, Millard WJ. Changes in anterior pituitary hormone secretion and hypothalamic catecholamine metabolism during morphine withdrawal in the female rat. Brain Research. 346: 15-21. PMID 4052762 DOI: 10.1016/0006-8993(85)91089-3  0.612
1984 Estes KS, Simpkins JW. Age-related alterations in dopamine and norepinephrine activity within microdissected brain regions of ovariectomized Long Evans rats. Brain Research. 298: 209-18. PMID 6609745 DOI: 10.1016/0006-8993(84)91420-3  0.303
1984 Simpkins JW. Spontaneous skin flushing episodes in the aging female rat. Maturitas. 6: 269-78. PMID 6542621 DOI: 10.1016/0378-5122(84)90043-4  0.313
1984 Katovich MJ, Simpkins JW, Song IC, Bodor N, Tuttle R. A rapid, quantitative in vivo assay for narcotic antagonists. Substance and Alcohol Actions/Misuse. 5: 87-95. PMID 6540897  0.575
1984 DeVane CL, Simpkins JW, Stout SA. Cerebral and blood pharmacokinetics of imipramine and its active metabolites in the pregnant rat. Psychopharmacology. 84: 225-30. PMID 6438681 DOI: 10.1007/Bf00427450  0.301
1984 Gabriel SM, Simpkins JW, Millard WJ. The effects of chronic naloxone on pituitary hormone secretion in female rats. Brain Research Bulletin. 12: 359-62. PMID 6329481 DOI: 10.1016/0361-9230(84)90104-7  0.601
1984 Simpkins JW, Taylor ST, Gabriel SM, Katovich MJ, Millard WJ. Evidence that chronic hyperprolactinemia effects skin temperature regulation through an opioid mechanism. Neuroendocrinology. 39: 321-9. PMID 6092986 DOI: 10.1159/000123999  0.691
1983 Simpkins JW, Katovich MJ, Song IC. Similarities between morphine withdrawal in the rat and the menopausal hot flush. Life Sciences. 32: 1957-66. PMID 6835016 DOI: 10.1016/0024-3205(83)90047-4  0.616
1983 Simpkins JW, Estes KS, Millard WJ, Sagar SM, Martin JB. Cysteamine depletes prolactin in young and old hyperprolactinemic rats. Endocrinology. 112: 1889-91. PMID 6832077 DOI: 10.1210/Endo-112-5-1889  0.602
1983 Millard WJ, Sagar SM, Simpkins JW, Owens RE, Badger TM, Friesen HG, Martin JB. Cysteamine induces depletion of both immunological and biological prolactin activity in the anterior pituitary and blood of the rat. Endocrinology. 113: 2161-7. PMID 6641630 DOI: 10.1210/Endo-113-6-2161  0.604
1983 Kalra PS, Simpkins JW, Luttge WG, Kalra SP. Effects on male sex behavior and preoptic dopamine neurons of hyperprolactinemia induced by MtTW15 pituitary tumors. Endocrinology. 113: 2065-71. PMID 6641626 DOI: 10.1210/Endo-113-6-2065  0.302
1983 Katovich MJ, Simpkins JW. Effects of chronic hyperprolactinaemia on experimentally induced thirsts in male rats. The Journal of Physiology. 341: 75-83. PMID 6620192 DOI: 10.1113/jphysiol.1983.sp014793  0.517
1983 Gabriel SM, Simpkins JW, Kalra SP. Modulation of endogenous opioid influence on luteinizing hormone secretion by progesterone and estrogen. Endocrinology. 113: 1806-11. PMID 6313330 DOI: 10.1210/Endo-113-5-1806  0.306
1982 Estes KS, Simpkins JW, Kalra SP. Normal LHRH neuronal function and hyperprolactinemia in old pseudopregnant Fischer 344 rats. Neurobiology of Aging. 3: 247-52. PMID 6761596 DOI: 10.1016/0197-4580(82)90047-1  0.32
1982 Estes KS, Simpkins JW, Kalra SP. Resumption with clonidine of pulsatile LH release following acute norepinephrine depletion in ovariectomized rats. Neuroendocrinology. 35: 56-62. PMID 6287329 DOI: 10.1159/000123355  0.323
1981 Kalra SP, Simpkins JW, Kalra PS. Progesterone-induced changes in hypothalamic luteinizing hormone-releasing hormone and catecholamines: differential effects of pentobarbital. Endocrinology. 108: 1299-304. PMID 6781870 DOI: 10.1210/Endo-108-4-1299  0.322
1981 Kalra SP, Simpkins JW. Evidence for noradrenergic mediation of opioid effects on luteinizing hormone secretion. Endocrinology. 109: 776-82. PMID 6266805 DOI: 10.1210/Endo-109-3-776  0.304
1980 Lu KH, Simpkins JW, Chen HT, Meites J. Patterns of pituitary LH release during sustained stimulation by synthetic LED in cycling female rats. Materia Medica Polona. Polish Journal of Medicine and Pharmacy. 12: 63-9. PMID 7035764  0.405
1980 Simpkins JW, Kalra PS, Kalra SP. Temporal alterations in luteinizing hormone-releasing hormone concentrations in several discrete brain regions: effects of estrogen-progesterone and norepinephrine synthesis inhibition. Endocrinology. 107: 573-7. PMID 6248329 DOI: 10.1210/Endo-107-2-573  0.308
1979 Simpkins JW, Huang HH, Advis JP, Meites J. Changes in hypothalamic NE an DA turnover resulting from steroid-induced LH and prolactin surges in ovariectomized rats. Biology of Reproduction. 20: 625-32. PMID 454758 DOI: 10.1095/Biolreprod20.3.625  0.498
1979 Simpkins JW, Advis JP, Hodson CA, Meites J. Blockade of steroid-induced leuteinizing hormone release by selective depletion of anterior hypothalamic norepinephrine activity. Endocrinology. 104: 506-9. PMID 446372 DOI: 10.1210/Endo-104-2-506  0.494
1979 Simpkins JW, Kalra SP. Blockade of progesterone-induced increase in hypothalamic luteinizing hormone-releasing hormone levels and serum gonadotropins by intrahypothalamic implantation of 6-hydroxydopamine. Brain Research. 170: 475-84. PMID 223726 DOI: 10.1016/0006-8993(79)90965-X  0.313
1979 Advis JP, Simpkins JW, Bennett J, Meites J. Serotonergic control of prolactin release in male rats. Life Sciences. 24: 359-65. PMID 155186 DOI: 10.1016/0024-3205(79)90332-1  0.479
1978 Simpkins JW, Hodson CA, Meites J. Differential effects of stress on release of thyroid-stimulating hormone in young and old male rats. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 157: 144-7. PMID 622368 DOI: 10.3181/00379727-157-40009  0.492
1978 Advis JP, Simpkins JW, Chen HT, Meites J. Relation of biogenic amines to onset of puberty in the female rat. Endocrinology. 103: 11-6. PMID 369837 DOI: 10.1210/Endo-103-1-11  0.462
1978 Hodson CA, Simpkins JW, Meites J. Inhibition of luteinizing hormone release and luteinizing hormone releasing hormone action by the ovaries of postpartum lactating rats. Endocrinology. 102: 832-6. PMID 369827 DOI: 10.1210/Endo-102-3-832  0.51
1977 Simpkins JW, Mueller GP, Huang HH, Meites J. Evidence for depressed catecholamine and enhanced serotonin metabolism in aging male rats: posssible relation to gondotropin secretion. Endocrinology. 100: 1672-8. PMID 870310 DOI: 10.1210/Endo-100-6-1672  0.491
1977 Grandison L, Hodson C, Chen HT, Advis J, Simpkins J, Meites J. Inhibition by prolactin of post-castration rise in LH. Neuroendocrinology. 23: 312-22. PMID 339120 DOI: 10.1159/000122679  0.479
1977 Chen HT, Simpkins JW, Mueller GP, Meites J. Effects of pargyline on hypothalamic biogenic amines and serum prolactin. LH and TSH in male rats. Life Sciences. 21: 533-41. PMID 143580 DOI: 10.1016/0024-3205(77)90093-5  0.481
1976 Gudelsky GA, Simpkins J, Mueller GP, Meites J, Moore KE. Selective actions of prolactin on catecholamine turnover in the hypothalamus and on serum LH and FSH. Neuroendocrinology. 22: 206-15. PMID 1028951 DOI: 10.1159/000122627  0.488
1976 Mueller GP, Simpkins J, Meites J, Moore KE. Differential effects of dopamine agonists and haloperidol on release of prolactin, thyroid stimulating hormone, growth hormone and luteinizing hormone in rats. Neuroendocrinology. 20: 121-35. PMID 958594 DOI: 10.1159/000122476  0.482
1976 Simpkins JW, Bruni JF, Mioduszewski RJ, Meites J. Serum and pituitary TSH and response to TRH in developing male and female rats. Endocrinology. 98: 1365-9. PMID 819250 DOI: 10.1210/Endo-98-6-1365  0.477
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