Year |
Citation |
Score |
2015 |
Brust TF, Hayes MP, Roman DL, Burris KD, Watts VJ. Bias analyses of preclinical and clinical D2 dopamine ligands: studies with immediate and complex signaling pathways. The Journal of Pharmacology and Experimental Therapeutics. 352: 480-93. PMID 25539635 DOI: 10.1124/jpet.114.220293 |
0.52 |
|
2015 |
Brust TF, Hayes MP, Roman DL, Watts VJ. New functional activity of aripiprazole revealed: Robust antagonism of D2 dopamine receptor-stimulated Gβγ signaling. Biochemical Pharmacology. 93: 85-91. PMID 25449598 DOI: 10.1016/j.bcp.2014.10.014 |
0.52 |
|
2013 |
Zhang X, Hagen J, Muniz VP, Smith T, Coombs GS, Eischen CM, Mackie DI, Roman DL, Van Rheeden R, Darbro B, Tompkins VS, Quelle DE. RABL6A, a novel RAB-like protein, controls centrosome amplification and chromosome instability in primary fibroblasts. Plos One. 8: e80228. PMID 24282525 DOI: 10.1371/journal.pone.0080228 |
0.52 |
|
2013 |
Monroy CA, Doorn JA, Roman DL. Modification and functional inhibition of regulator of G-protein signaling 4 (RGS4) by 4-hydroxy-2-nonenal. Chemical Research in Toxicology. 26: 1832-9. PMID 24229325 DOI: 10.1021/tx400212q |
0.52 |
|
2013 |
Bodle CR, Mackie DI, Roman DL. RGS17: an emerging therapeutic target for lung and prostate cancers. Future Medicinal Chemistry. 5: 995-1007. PMID 23734683 DOI: 10.4155/fmc.13.91 |
0.52 |
|
2013 |
Monroy CA, Mackie DI, Roman DL. A high throughput screen for RGS proteins using steady state monitoring of free phosphate formation. Plos One. 8: e62247. PMID 23626793 DOI: 10.1371/journal.pone.0062247 |
0.52 |
|
2013 |
Vermeer LM, Higgins CA, Roman DL, Doorn JA. Real-time monitoring of tyrosine hydroxylase activity using a plate reader assay. Analytical Biochemistry. 432: 11-5. PMID 23010244 DOI: 10.1016/j.ab.2012.09.005 |
0.52 |
|
2012 |
Higgins CA, Vermeer LM, Doorn JA, Roman DL. Expression and purification of recombinant human tyrosine hydroxylase as a fusion protein in Escherichia coli. Protein Expression and Purification. 84: 219-23. PMID 22659380 DOI: 10.1016/j.pep.2012.05.007 |
0.52 |
|
2011 |
Roman DL, Traynor JR. Regulators of G protein signaling (RGS) proteins as drug targets: modulating G-protein-coupled receptor (GPCR) signal transduction. Journal of Medicinal Chemistry. 54: 7433-40. PMID 21916427 DOI: 10.1021/jm101572n |
0.52 |
|
2011 |
Mackie DI, Roman DL. Development of a novel high-throughput screen and identification of small-molecule inhibitors of the Gα-RGS17 protein-protein interaction using AlphaScreen. Journal of Biomolecular Screening. 16: 869-77. PMID 21680864 DOI: 10.1177/1087057111410427 |
0.52 |
|
2010 |
Blazer LL, Roman DL, Chung A, Larsen MJ, Greedy BM, Husbands SM, Neubig RR. Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins. Molecular Pharmacology. 78: 524-33. PMID 20571077 DOI: 10.1124/mol.110.065128 |
0.52 |
|
2010 |
Roman DL, Blazer LL, Monroy CA, Neubig RR. Allosteric inhibition of the regulator of G protein signaling-Galpha protein-protein interaction by CCG-4986. Molecular Pharmacology. 78: 360-5. PMID 20530129 DOI: 10.1124/mol.109.063388 |
0.52 |
|
2010 |
Blazer LL, Roman DL, Muxlow MR, Neubig RR. Use of flow cytometric methods to quantify protein-protein interactions. Current Protocols in Cytometry / Editorial Board, J. Paul Robinson, Managing Editor ... [Et Al.]. Unit 13.11.1-15. PMID 20069525 DOI: 10.1002/0471142956.cy1311s51 |
0.52 |
|
2010 |
Talbot JN, Roman DL, Clark MJ, Roof RA, Tesmer JJ, Neubig RR, Traynor JR. Differential modulation of mu-opioid receptor signaling to adenylyl cyclase by regulators of G protein signaling proteins 4 or 8 and 7 in permeabilised C6 cells is Galpha subtype dependent. Journal of Neurochemistry. 112: 1026-34. PMID 20002516 DOI: 10.1111/j.1471-4159.2009.06519.x |
0.52 |
|
2009 |
Roman DL. Identification of ligands targeting RGS proteins high-throughput screening and therapeutic potential. Progress in Molecular Biology and Translational Science. 86: 335-56. PMID 20374721 DOI: 10.1016/S1877-1173(09)86011-0 |
0.52 |
|
2009 |
Roman DL, Ota S, Neubig RR. Polyplexed flow cytometry protein interaction assay: a novel high-throughput screening paradigm for RGS protein inhibitors. Journal of Biomolecular Screening. 14: 610-9. PMID 19531661 DOI: 10.1177/1087057109336590 |
0.52 |
|
2009 |
Roof RA, Roman DL, Clements ST, Sobczyk-Kojiro K, Blazer LL, Ota S, Mosberg HI, Neubig RR. A covalent peptide inhibitor of RGS4 identified in a focused one-bead, one compound library screen. Bmc Pharmacology. 9: 9. PMID 19463173 DOI: 10.1186/1471-2210-9-9 |
0.52 |
|
2008 |
Shankaranarayanan A, Thal DM, Tesmer VM, Roman DL, Neubig RR, Kozasa T, Tesmer JJ. Assembly of high order G alpha q-effector complexes with RGS proteins. The Journal of Biological Chemistry. 283: 34923-34. PMID 18936096 DOI: 10.1074/jbc.M805860200 |
0.52 |
|
2008 |
Bernsteel DJ, Roman DL, Neubig RR. In vitro protein kinase activity measurement by flow cytometry. Analytical Biochemistry. 383: 180-5. PMID 18796290 DOI: 10.1016/j.ab.2008.08.026 |
0.52 |
|
2008 |
Roof RA, Sobczyk-Kojiro K, Turbiak AJ, Roman DL, Pogozheva ID, Blazer LL, Neubig RR, Mosberg HI. Novel peptide ligands of RGS4 from a focused one-bead, one-compound library. Chemical Biology & Drug Design. 72: 111-9. PMID 18637987 DOI: 10.1111/j.1747-0285.2008.00687.x |
0.52 |
|
2008 |
Pei J, Dishinger JF, Roman DL, Rungwanitcha C, Neubig RR, Kennedy RT. Microfabricated channel array electrophoresis for characterization and screening of enzymes using RGS-G protein interactions as a model system. Analytical Chemistry. 80: 5225-31. PMID 18465881 DOI: 10.1021/ac800553g |
0.52 |
|
2007 |
Roman DL, Talbot JN, Roof RA, Sunahara RK, Traynor JR, Neubig RR. Identification of small-molecule inhibitors of RGS4 using a high-throughput flow cytometry protein interaction assay. Molecular Pharmacology. 71: 169-75. PMID 17012620 DOI: 10.1124/mol.106.028670 |
0.52 |
|
2006 |
Roof RA, Jin Y, Roman DL, Sunahara RK, Ishii M, Mosberg HI, Neubig RR. Mechanism of action and structural requirements of constrained peptide inhibitors of RGS proteins. Chemical Biology & Drug Design. 67: 266-74. PMID 16629824 DOI: 10.1111/j.1747-0285.2006.00373.x |
0.52 |
|
2004 |
Roman DL, Saldaña SN, Nichols DE, Carroll FI, Barker EL. Distinct molecular recognition of psychostimulants by human and Drosophila serotonin transporters. The Journal of Pharmacology and Experimental Therapeutics. 308: 679-87. PMID 14593087 DOI: 10.1124/jpet.103.057836 |
0.52 |
|
2003 |
Roman DL, Walline CC, Rodriguez GJ, Barker EL. Interactions of antidepressants with the serotonin transporter: a contemporary molecular analysis. European Journal of Pharmacology. 479: 53-63. PMID 14612137 DOI: 10.1016/j.ejphar.2003.08.056 |
0.52 |
|
2003 |
Rodríguez GJ, Roman DL, White KJ, Nichols DE, Barker EL. Distinct recognition of substrates by the human and Drosophila serotonin transporters. The Journal of Pharmacology and Experimental Therapeutics. 306: 338-46. PMID 12682215 DOI: 10.1124/jpet.103.048751 |
0.52 |
|
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