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David L. Roman - Publications

Affiliations: 
University of Iowa, Iowa City, IA 
Area:
RGS Proteins, Drug Discovery & HTS
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26 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Brust TF, Hayes MP, Roman DL, Burris KD, Watts VJ. Bias analyses of preclinical and clinical D2 dopamine ligands: studies with immediate and complex signaling pathways. The Journal of Pharmacology and Experimental Therapeutics. 352: 480-93. PMID 25539635 DOI: 10.1124/jpet.114.220293  0.52
2015 Brust TF, Hayes MP, Roman DL, Watts VJ. New functional activity of aripiprazole revealed: Robust antagonism of D2 dopamine receptor-stimulated Gβγ signaling. Biochemical Pharmacology. 93: 85-91. PMID 25449598 DOI: 10.1016/j.bcp.2014.10.014  0.52
2013 Zhang X, Hagen J, Muniz VP, Smith T, Coombs GS, Eischen CM, Mackie DI, Roman DL, Van Rheeden R, Darbro B, Tompkins VS, Quelle DE. RABL6A, a novel RAB-like protein, controls centrosome amplification and chromosome instability in primary fibroblasts. Plos One. 8: e80228. PMID 24282525 DOI: 10.1371/journal.pone.0080228  0.52
2013 Monroy CA, Doorn JA, Roman DL. Modification and functional inhibition of regulator of G-protein signaling 4 (RGS4) by 4-hydroxy-2-nonenal. Chemical Research in Toxicology. 26: 1832-9. PMID 24229325 DOI: 10.1021/tx400212q  0.52
2013 Bodle CR, Mackie DI, Roman DL. RGS17: an emerging therapeutic target for lung and prostate cancers. Future Medicinal Chemistry. 5: 995-1007. PMID 23734683 DOI: 10.4155/fmc.13.91  0.52
2013 Monroy CA, Mackie DI, Roman DL. A high throughput screen for RGS proteins using steady state monitoring of free phosphate formation. Plos One. 8: e62247. PMID 23626793 DOI: 10.1371/journal.pone.0062247  0.52
2013 Vermeer LM, Higgins CA, Roman DL, Doorn JA. Real-time monitoring of tyrosine hydroxylase activity using a plate reader assay. Analytical Biochemistry. 432: 11-5. PMID 23010244 DOI: 10.1016/j.ab.2012.09.005  0.52
2012 Higgins CA, Vermeer LM, Doorn JA, Roman DL. Expression and purification of recombinant human tyrosine hydroxylase as a fusion protein in Escherichia coli. Protein Expression and Purification. 84: 219-23. PMID 22659380 DOI: 10.1016/j.pep.2012.05.007  0.52
2011 Roman DL, Traynor JR. Regulators of G protein signaling (RGS) proteins as drug targets: modulating G-protein-coupled receptor (GPCR) signal transduction. Journal of Medicinal Chemistry. 54: 7433-40. PMID 21916427 DOI: 10.1021/jm101572n  0.52
2011 Mackie DI, Roman DL. Development of a novel high-throughput screen and identification of small-molecule inhibitors of the Gα-RGS17 protein-protein interaction using AlphaScreen. Journal of Biomolecular Screening. 16: 869-77. PMID 21680864 DOI: 10.1177/1087057111410427  0.52
2010 Blazer LL, Roman DL, Chung A, Larsen MJ, Greedy BM, Husbands SM, Neubig RR. Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins. Molecular Pharmacology. 78: 524-33. PMID 20571077 DOI: 10.1124/mol.110.065128  0.52
2010 Roman DL, Blazer LL, Monroy CA, Neubig RR. Allosteric inhibition of the regulator of G protein signaling-Galpha protein-protein interaction by CCG-4986. Molecular Pharmacology. 78: 360-5. PMID 20530129 DOI: 10.1124/mol.109.063388  0.52
2010 Blazer LL, Roman DL, Muxlow MR, Neubig RR. Use of flow cytometric methods to quantify protein-protein interactions. Current Protocols in Cytometry / Editorial Board, J. Paul Robinson, Managing Editor ... [Et Al.]. Unit 13.11.1-15. PMID 20069525 DOI: 10.1002/0471142956.cy1311s51  0.52
2010 Talbot JN, Roman DL, Clark MJ, Roof RA, Tesmer JJ, Neubig RR, Traynor JR. Differential modulation of mu-opioid receptor signaling to adenylyl cyclase by regulators of G protein signaling proteins 4 or 8 and 7 in permeabilised C6 cells is Galpha subtype dependent. Journal of Neurochemistry. 112: 1026-34. PMID 20002516 DOI: 10.1111/j.1471-4159.2009.06519.x  0.52
2009 Roman DL. Identification of ligands targeting RGS proteins high-throughput screening and therapeutic potential. Progress in Molecular Biology and Translational Science. 86: 335-56. PMID 20374721 DOI: 10.1016/S1877-1173(09)86011-0  0.52
2009 Roman DL, Ota S, Neubig RR. Polyplexed flow cytometry protein interaction assay: a novel high-throughput screening paradigm for RGS protein inhibitors. Journal of Biomolecular Screening. 14: 610-9. PMID 19531661 DOI: 10.1177/1087057109336590  0.52
2009 Roof RA, Roman DL, Clements ST, Sobczyk-Kojiro K, Blazer LL, Ota S, Mosberg HI, Neubig RR. A covalent peptide inhibitor of RGS4 identified in a focused one-bead, one compound library screen. Bmc Pharmacology. 9: 9. PMID 19463173 DOI: 10.1186/1471-2210-9-9  0.52
2008 Shankaranarayanan A, Thal DM, Tesmer VM, Roman DL, Neubig RR, Kozasa T, Tesmer JJ. Assembly of high order G alpha q-effector complexes with RGS proteins. The Journal of Biological Chemistry. 283: 34923-34. PMID 18936096 DOI: 10.1074/jbc.M805860200  0.52
2008 Bernsteel DJ, Roman DL, Neubig RR. In vitro protein kinase activity measurement by flow cytometry. Analytical Biochemistry. 383: 180-5. PMID 18796290 DOI: 10.1016/j.ab.2008.08.026  0.52
2008 Roof RA, Sobczyk-Kojiro K, Turbiak AJ, Roman DL, Pogozheva ID, Blazer LL, Neubig RR, Mosberg HI. Novel peptide ligands of RGS4 from a focused one-bead, one-compound library. Chemical Biology & Drug Design. 72: 111-9. PMID 18637987 DOI: 10.1111/j.1747-0285.2008.00687.x  0.52
2008 Pei J, Dishinger JF, Roman DL, Rungwanitcha C, Neubig RR, Kennedy RT. Microfabricated channel array electrophoresis for characterization and screening of enzymes using RGS-G protein interactions as a model system. Analytical Chemistry. 80: 5225-31. PMID 18465881 DOI: 10.1021/ac800553g  0.52
2007 Roman DL, Talbot JN, Roof RA, Sunahara RK, Traynor JR, Neubig RR. Identification of small-molecule inhibitors of RGS4 using a high-throughput flow cytometry protein interaction assay. Molecular Pharmacology. 71: 169-75. PMID 17012620 DOI: 10.1124/mol.106.028670  0.52
2006 Roof RA, Jin Y, Roman DL, Sunahara RK, Ishii M, Mosberg HI, Neubig RR. Mechanism of action and structural requirements of constrained peptide inhibitors of RGS proteins. Chemical Biology & Drug Design. 67: 266-74. PMID 16629824 DOI: 10.1111/j.1747-0285.2006.00373.x  0.52
2004 Roman DL, Saldaña SN, Nichols DE, Carroll FI, Barker EL. Distinct molecular recognition of psychostimulants by human and Drosophila serotonin transporters. The Journal of Pharmacology and Experimental Therapeutics. 308: 679-87. PMID 14593087 DOI: 10.1124/jpet.103.057836  0.52
2003 Roman DL, Walline CC, Rodriguez GJ, Barker EL. Interactions of antidepressants with the serotonin transporter: a contemporary molecular analysis. European Journal of Pharmacology. 479: 53-63. PMID 14612137 DOI: 10.1016/j.ejphar.2003.08.056  0.52
2003 Rodríguez GJ, Roman DL, White KJ, Nichols DE, Barker EL. Distinct recognition of substrates by the human and Drosophila serotonin transporters. The Journal of Pharmacology and Experimental Therapeutics. 306: 338-46. PMID 12682215 DOI: 10.1124/jpet.103.048751  0.52
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