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Marina V. Evans - Publications

Affiliations: 
Applied Mathematics North Carolina State University, Raleigh, NC 
Area:
Applied Mathematics, Pharmacology
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Year Citation  Score
2020 Evans MV, Eklund CR, Williams DN, Sey YM, Simmons JE. Global optimization of the Michaelis-Menten parameters using physiologically-based pharmacokinetic (PBPK) modeling and chloroform vapor uptake data in F344 rats. Inhalation Toxicology. 1-13. PMID 32241199 DOI: 10.1080/08958378.2020.1742818  0.466
2017 Sawyer ME, Tran HT, Evans MV. A physiologically based pharmacokinetic model of vitamin D. Journal of Applied Toxicology : Jat. PMID 28585774 DOI: 10.1002/Jat.3489  0.648
2016 Sawyer ME, Evans MV, Wilson CA, Beesley LJ, Leon LS, Eklund CR, Croom EL, Pegram RA. Development of a Human Physiologically Based Pharmacokinetic (PBPK) Model for Dermal Permeability for Lindane. Toxicology Letters. PMID 26794662 DOI: 10.1016/J.Toxlet.2016.01.008  0.66
2015 Croom EL, Shafer TJ, Evans MV, Mundy WR, Eklund CR, Johnstone AF, Mack CM, Pegram RA. Improving in vitro to in vivo extrapolation by incorporating toxicokinetic measurements: a case study of lindane-induced neurotoxicity. Toxicology and Applied Pharmacology. 283: 9-19. PMID 25529470 DOI: 10.1016/J.Taap.2014.11.006  0.409
2012 Caldwell JC, Krishnan K, Evans MV. State of the science: biologically based modeling in risk assessment. Journal of Toxicology. 2012: 758182. PMID 23251151 DOI: 10.1155/2012/758182  0.367
2012 Caldwell JC, Evans MV, Krishnan K. Cutting Edge PBPK Models and Analyses: Providing the Basis for Future Modeling Efforts and Bridges to Emerging Toxicology Paradigms. Journal of Toxicology. 2012: 852384. PMID 22899915 DOI: 10.1155/2012/852384  0.446
2012 Cuello WS, Janes TA, Jessee JM, Venecek MA, Sawyer ME, Eklund CR, Evans MV. Physiologically Based Pharmacokinetic (PBPK) Modeling of Metabolic Pathways of Bromochloromethane in Rats. Journal of Toxicology. 2012: 629781. PMID 22719758 DOI: 10.1155/2012/629781  0.665
2010 Evans MV, Caldwell JC. Evaluation of two different metabolic hypotheses for dichloromethane toxicity using physiologically based pharmacokinetic modeling for in vivo inhalation gas uptake data exposure in female B6C3F1 mice. Toxicology and Applied Pharmacology. 244: 280-90. PMID 20153349 DOI: 10.1016/J.Taap.2010.01.018  0.445
2009 El-Masri HA, Dowd S, Pegram RA, Harrison R, Yavanhxay SJ, Simmons JE, Evans M. Development of an inhalation physiologically based pharmacokinetic (PBPK) model for 2,2, 4-trimethylpentane (TMP) in male Long-Evans rats using gas uptake experiments Inhalation Toxicology. 21: 1176-1185. PMID 19922404 DOI: 10.3109/08958370903005751  0.42
2009 Chiu WA, Okino MS, Evans MV. Characterizing uncertainty and population variability in the toxicokinetics of trichloroethylene and metabolites in mice, rats, and humans using an updated database, physiologically based pharmacokinetic (PBPK) model, and Bayesian approach. Toxicology and Applied Pharmacology. 241: 36-60. PMID 19660485 DOI: 10.1016/J.Taap.2009.07.032  0.453
2009 Evans MV, Chiu WA, Okino MS, Caldwell JC. Development of an updated PBPK model for trichloroethylene and metabolites in mice, and its application to discern the role of oxidative metabolism in TCE-induced hepatomegaly. Toxicology and Applied Pharmacology. 236: 329-40. PMID 19249323 DOI: 10.1016/J.Taap.2009.02.013  0.435
2009 Draper B, Marcin D, Margolskee A, Murden R, Attarian A, Evans MV, Yokley KA. Feasibility of metabolic parameter estimation in pharmacokinetic models of carbon tetrachloride exposure in rats Toxicological and Environmental Chemistry. 91: 521-546. DOI: 10.1080/02772240802214530  0.486
2008 Evans MV, Dowd SM, Kenyon EM, Hughes MF, El-Masri HA. A physiologically based pharmacokinetic model for intravenous and ingested dimethylarsinic acid in mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 104: 250-60. PMID 18430741 DOI: 10.1093/Toxsci/Kfn080  0.426
2008 Caldwell JC, Keshava N, Evans MV. Difficulty of mode of action determination for trichloroethylene: An example of complex interactions of metabolites and other chemical exposures. Environmental and Molecular Mutagenesis. 49: 142-54. PMID 17973308 DOI: 10.1002/Em.20350  0.349
2007 Yokley KA, Evans MV. An example of model structure differences using sensitivity analyses in physiologically based pharmacokinetic models of trichloroethylene in humans. Bulletin of Mathematical Biology. 69: 2591-625. PMID 17896160 DOI: 10.1007/S11538-007-9233-X  0.479
2006 Chiu WA, Okino MS, Lipscomb JC, Evans MV. Issues in the pharmacokinetics of trichloroethylene and its metabolites. Environmental Health Perspectives. 114: 1450-6. PMID 16966104 DOI: 10.1289/Ehp.8691  0.434
2005 Boyes WK, Evans MV, Eklund C, Janssen P, Simmons JE. Duration adjustment of acute exposure guideline level values for trichloroethylene using a physiologically-based pharmacokinetic model. Risk Analysis : An Official Publication of the Society For Risk Analysis. 25: 677-86. PMID 16022699 DOI: 10.1111/J.1539-6924.2005.00622.X  0.379
2005 Simmons JE, Evans MV, Boyes WK. Moving from external exposure concentration to internal dose: duration extrapolation based on physiologically based pharmacokinetic derived estimates of internal dose. Journal of Toxicology and Environmental Health. Part A. 68: 927-50. PMID 16020185 DOI: 10.1080/15287390590912586  0.369
2005 Boyes WK, Bercegeay M, Krantz T, Evans M, Benignus V, Simmons JE. Momentary brain concentration of trichloroethylene predicts the effects on rat visual function. Toxicological Sciences : An Official Journal of the Society of Toxicology. 87: 187-96. PMID 15976185 DOI: 10.1093/Toxsci/Kfi242  0.327
2005 Granville CA, Ross MK, Tornero-Velez R, Hanley NM, Grindstaff RD, Gold A, Richard AM, Funasaka K, Tennant AH, Kligerman AD, Evans MV, DeMarini DM. Genotoxicity and metabolism of the source-water contaminant 1,1-dichloropropene: activation by GSTT1-1 and structure-activity considerations. Mutation Research. 572: 98-112. PMID 15790493 DOI: 10.1016/J.Mrfmmm.2004.12.009  0.311
2004 Isaacs KK, Evans MV, Harris TR. Visualization-based analysis for a mixed-inhibition binary PBPK model: determination of inhibition mechanism. Journal of Pharmacokinetics and Pharmacodynamics. 31: 215-42. PMID 15518245 DOI: 10.1023/B:Jopa.0000039565.11358.94  0.398
2004 Lipscomb JC, Barton HA, Tornero-Velez R, Evans MV, Alcasey S, Snawder JE, Laskey J. The metabolic rate constants and specific activity of human and rat hepatic cytochrome P-450 2E1 toward toluene and chloroform. Journal of Toxicology and Environmental Health. Part A. 67: 537-53. PMID 15129551 DOI: 10.1080/15287390490425588  0.412
2004 Himmelstein MW, Carpenter SC, Evans MV, Hinderliter PM, Kenyon EM. Kinetic modeling of beta-chloroprene metabolism: II. The application of physiologically based modeling for cancer dose response analysis. Toxicological Sciences : An Official Journal of the Society of Toxicology. 79: 28-37. PMID 14976335 DOI: 10.1093/Toxsci/Kfh096  0.413
2004 Tornero-Velez R, Ross MK, Granville C, Laskey J, Jones JP, DeMarini DM, Evans MV. Metabolism and mutagenicity of source water contaminants 1,3-dichloropropane and 2,2-dichloropropane. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 32: 123-31. PMID 14709629 DOI: 10.1124/Dmd.32.1.123  0.36
2003 Boyes WK, Bercegeay M, Ali JS, Krantz T, McGee J, Evans M, Raymer JH, Bushnell PJ, Simmons JE. Dose-based duration adjustments for the effects of inhaled trichloroethylene on rat visual function. Toxicological Sciences : An Official Journal of the Society of Toxicology. 76: 121-30. PMID 12915717 DOI: 10.1093/Toxsci/Kfg213  0.327
2003 Kenyon EM, Hughes MF, Evans MV, Styblo M, Del Razo LM, Easterling M. Incorporating mechanistic insights in a PBPK model for arsenic Arsenic Exposure and Health Effects V. 369-377. DOI: 10.1016/B978-044451441-7/50029-4  0.346
2002 Easterling MR, Styblo M, Evans MV, Kenyon EM. Pharmacokinetic modeling of arsenite uptake and metabolism in hepatocytes--mechanistic insights and implications for further experiments. Journal of Pharmacokinetics and Pharmacodynamics. 29: 207-34. PMID 12449496 DOI: 10.1023/A:1020248922689  0.445
2002 Simmons JE, Boyes WK, Bushnell PJ, Raymer JH, Limsakun T, McDonald A, Sey YM, Evans MV. A physiologically based pharmacokinetic model for trichloroethylene in the male Long-Evans rat Toxicological Sciences. 69: 3-15. PMID 12215655 DOI: 10.1093/Toxsci/69.1.3  0.383
2002 Evans MV, Boyes WK, Simmons JE, Litton DK, Easterling MR. A comparison of Haber's rule at different ages using a physiologically based pharmacokinetic (PBPK) model for chloroform in rats Toxicology. 176: 11-23. PMID 12062926 DOI: 10.1016/S0300-483X(02)00090-2  0.36
2002 Albanese RA, Banks HT, Evans MV, Potter LK. Physiologically based pharmacokinetic models for the transport of trichloroethylene in adipose tissue. Bulletin of Mathematical Biology. 64: 97-131. PMID 11868339 DOI: 10.1006/Bulm.2001.0268  0.401
2001 Kenyon EM, Fea M, Styblo M, Evans MV. Application of modelling techniques to the planning of in vitro arsenic kinetic studies Atla Alternatives to Laboratory Animals. 29: 15-33. PMID 11178572 DOI: 10.1177/026119290102900109  0.441
2001 Evans MV, Eklund CR. A graphical application of sensitivity analysis for gas uptake experiments using chloroform as an example Toxicology Methods. 11: 285-297. DOI: 10.1080/15376510109162664  0.461
2000 Boyes WK, Bushnell PJ, Crofton KM, Evans M, Simmons JE. Neurotoxic and pharmacokinetic responses to trichloroethylene as a function of exposure scenario. Environmental Health Perspectives. 108: 317-22. PMID 10807561 DOI: 10.1289/Ehp.00108S2317  0.362
2000 Evans MV, Andersen ME. Sensitivity analysis of a physiological model for 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD): Assessing the impact of specific model parameters on sequestration in liver and fat in the rat Toxicological Sciences. 54: 71-80. PMID 10746933 DOI: 10.1093/Toxsci/54.1.71  0.394
2000 Eaterling MR, Evans MV, Kenyon EM. Comparative analysis of software for physiologically based, pharmacokinetic modeling: Simulation, optimization, and sensitivity analysis Toxicology Methods. 10: 203-229. DOI: 10.1080/10517230050121615  0.39
1997 Wang X, Santostefano MJ, Evans MV, Richardson VM, Diliberto JJ, Birnbaum LS. Determination of parameters responsible for pharmacokinetic behavior of TCDD in female Sprague-Dawley rats Toxicology and Applied Pharmacology. 147: 151-168. PMID 9356318 DOI: 10.1006/Taap.1997.8242  0.502
1996 Evans MV, Simmons JE. Physiologically based pharmacokinetic estimated metabolic constants and hepatotoxicity of carbon tetrachloride after methanol pretreatment in rats Toxicology and Applied Pharmacology. 140: 245-253. PMID 8887440 DOI: 10.1006/Taap.1996.0219  0.384
1996 Waller CL, Evans MV, Mckinney JD. Modeling the cytochrome P450-mediated metabolism of chlorinated volatile organic compounds Drug Metabolism and Disposition. 24: 203-210. PMID 8742232  0.322
1995 Evans MV, Andersen ME. Sensitivity analysis and the design of gas uptake inhalation studies Inhalation Toxicology. 7: 1075-1094. DOI: 10.3109/08958379509002568  0.436
1994 Evans MV, Crank WD, Yang HM, Simmons JE. Applications of sensitivity analysis to a physiologically based pharmacokinetic model for carbon tetrachloride in rats Toxicology and Applied Pharmacology. 128: 36-44. PMID 8079352 DOI: 10.1006/Taap.1994.1177  0.461
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