Rudolph E. Tanzi, PhD, Harvard University - Publications

Affiliations: 
Neurology Harvard Medical School, Boston, MA, United States 
Area:
http://www.researchprofiles.collexis.com/jad/expert.asp?u_id=11
Website:
http://www.mghmind.org/Faculty/tanzi_rudy.html

352 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Ning S, Jorfi M, Patel SR, Kim DY, Tanzi RE. Neurotechnological Approaches to the Diagnosis and Treatment of Alzheimer's Disease. Frontiers in Neuroscience. 16: 854992. PMID 35401082 DOI: 10.3389/fnins.2022.854992  0.812
2022 Zhang S, Bai P, Lei D, Liang Y, Zhen S, Bakiasi G, Pang H, Choi SH, Wang C, Tanzi RE, Zhang C. Degradation and Inhibition of Epigenetic Regulatory Protein BRD4 Exacerbate Alzheimer's Disease-Related Neuropathology in Cell Models. The Journal of Biological Chemistry. 101794. PMID 35248531 DOI: 10.1016/j.jbc.2022.101794  0.354
2022 Moncaster JA, Moir RD, Burton MA, Chadwick O, Minaeva O, Alvarez VE, Ericsson M, Clark JI, McKee AC, Tanzi RE, Goldstein LE. Alzheimer's disease amyloid-β pathology in the lens of the eye. Experimental Eye Research. 108974. PMID 35202705 DOI: 10.1016/j.exer.2022.108974  0.362
2022 Caldwell AB, Liu Q, Zhang C, Schroth GP, Galasko DR, Rynearson KD, Tanzi RE, Yuan SH, Wagner SL, Subramaniam S. Endotype reversal as a novel strategy for screening drugs targeting familial Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 35084109 DOI: 10.1002/alz.12553  0.314
2022 Lotlikar MS, Tarantino MB, Jorfi M, Kovacs DM, Tanzi RE, Bhattacharyya R. Microfluidic separation of axonal and somal compartments of neural progenitor cells differentiated in a 3D matrix. Star Protocols. 3: 101028. PMID 35059649 DOI: 10.1016/j.xpro.2021.101028  0.764
2021 Kim JJ, Jorfi M, Tanzi RE, Kim DY, Doyle PS, Irimia D. Patterning of interconnected human brain spheroids. Lab On a Chip. PMID 34286713 DOI: 10.1039/d0lc01112f  0.816
2021 McAlpine CS, Park J, Griciuc A, Kim E, Choi SH, Iwamoto Y, Kiss MG, Christie KA, Vinegoni C, Poller WC, Mindur JE, Chan CT, He S, Janssen H, Wong LP, ... ... Tanzi RE, et al. Astrocytic interleukin-3 programs microglia and limits Alzheimer's disease. Nature. PMID 34262178 DOI: 10.1038/s41586-021-03734-6  0.806
2021 Bhattacharyya R, Black SE, Lotlikar MS, Fenn RH, Jorfi M, Kovacs DM, Tanzi RE. Axonal generation of amyloid-β from palmitoylated APP in mitochondria-associated endoplasmic reticulum membranes. Cell Reports. 35: 109134. PMID 34010653 DOI: 10.1016/j.celrep.2021.109134  0.79
2021 Zhang X, Zhang CM, Prokopenko D, Liang Y, Zhen SY, Weigle IQ, Han W, Aryal M, Tanzi RE, Sisodia SS. An APP ectodomain mutation outside of the Aβ domain promotes Aβ production in vitro and deposition in vivo. The Journal of Experimental Medicine. 218. PMID 33822840 DOI: 10.1084/jem.20210313  0.31
2021 Shoup TM, Griciuc A, Normandin MD, Quinti L, Walsh LV, Dhaynaut M, Moon SH, Guehl NJ, Brugarolas P, Elmaleh DR, Fakhri GE, Tanzi RE. Evaluation of Fluorinated Cromolyn Derivatives as Potential Therapeutics for Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 33579853 DOI: 10.3233/JAD-201419  0.312
2020 Hong S, Prokopenko D, Dobricic V, Kilpert F, Bos I, Vos SJB, Tijms BM, Andreasson U, Blennow K, Vandenberghe R, Cleynen I, Gabel S, Schaeverbeke J, Scheltens P, Teunissen CE, ... ... Tanzi RE, et al. Genome-wide association study of Alzheimer's disease CSF biomarkers in the EMIF-AD Multimodal Biomarker Discovery dataset. Translational Psychiatry. 10: 403. PMID 33223526 DOI: 10.1038/s41398-020-01074-z  0.32
2020 Cenini G, Hebisch M, Iefremova V, Flitsch LJ, Breitkreuz Y, Tanzi RE, Kim DY, Peitz M, Brüstle O. Dissecting Alzheimer's disease pathogenesis in human 2D and 3D models. Molecular and Cellular Neurosciences. 103568. PMID 33068718 DOI: 10.1016/j.mcn.2020.103568  0.744
2020 Cuddy LK, Prokopenko D, Cunningham EP, Brimberry R, Song P, Kirchner R, Chapman BA, Hofmann O, Hide W, Procissi D, Hanania T, Leiser SC, Tanzi RE, Vassar R. Aβ-accelerated neurodegeneration caused by Alzheimer's-associated variant R1279Q is rescued by angiotensin system inhibition in mice. Science Translational Medicine. 12. PMID 32998969 DOI: 10.1126/scitranslmed.aaz2541  0.301
2020 Cuddy LK, Prokopenko D, Cunningham EP, Brimberry R, Song P, Kirchner R, Chapman BA, Hofmann O, Hide W, Procissi D, Hanania T, Leiser SC, Tanzi RE, Vassar R. Aβ-accelerated neurodegeneration caused by Alzheimer's-associated variant R1279Q is rescued by angiotensin system inhibition in mice. Science Translational Medicine. 12. PMID 32998969 DOI: 10.1126/scitranslmed.aaz2541  0.301
2020 Liu T, Zhu B, Liu Y, Zhang X, Yin J, Li X, Jiang L, Hodges AP, Rosenthal SB, Zhou L, Yancey J, McQuade A, Blurton-Jones M, Tanzi RE, Huang TY, et al. Multi-omic comparison of Alzheimer's variants in human ESC-derived microglia reveals convergence at APOE. The Journal of Experimental Medicine. 217. PMID 32941599 DOI: 10.1084/Jem.20200474  0.319
2020 Liu T, Zhu B, Liu Y, Zhang X, Yin J, Li X, Jiang L, Hodges AP, Rosenthal SB, Zhou L, Yancey J, McQuade A, Blurton-Jones M, Tanzi RE, Huang TY, et al. Multi-omic comparison of Alzheimer's variants in human ESC-derived microglia reveals convergence at APOE. The Journal of Experimental Medicine. 217. PMID 32941599 DOI: 10.1084/Jem.20200474  0.319
2020 Xu Y, Wang C, Wey HY, Liang Y, Chen Z, Choi SH, Ran C, Rynearson KD, Bernales DR, Koegel RE, Fiedler SA, Striar R, Wagner SL, Tanzi RE, Zhang C. Molecular imaging of Alzheimer's disease-related gamma-secretase in mice and nonhuman primates. The Journal of Experimental Medicine. 217. PMID 32936886 DOI: 10.1084/Jem.20182266  0.416
2020 Denner J, Tanzi R, Jacobson S. Animal Models of Alzheimer's Disease Should Be Controlled for Roseolovirus. Journal of Alzheimer's Disease : Jad. PMID 32804089 DOI: 10.3233/Jad-200591  0.39
2020 Liang Y, Raven F, Ward JF, Zhen S, Zhang S, Sun H, Miller SJ, Choi SH, Tanzi RE, Zhang C. Upregulation of Alzheimer's Disease Amyloid-β Protein Precursor in Astrocytes Both in vitro and in vivo. Journal of Alzheimer's Disease : Jad. PMID 32597805 DOI: 10.3233/Jad-200128  0.468
2020 Dujardin S, Commins C, Lathuiliere A, Beerepoot P, Fernandes AR, Kamath TV, De Los Santos MB, Klickstein N, Corjuc DL, Corjuc BT, Dooley PM, Viode A, Oakley DH, Moore BD, Mullin K, ... ... Tanzi RE, et al. Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease. Nature Medicine. PMID 32572268 DOI: 10.1038/S41591-020-0938-9  0.423
2020 Cable J, Holtzman DM, Hyman BT, Tansey MG, Colonna M, Kellis M, Brinton RD, Albert M, Wellington CL, Sisodia SS, Tanzi RE. Alternatives to amyloid for Alzheimer's disease therapies-a symposium report. Annals of the New York Academy of Sciences. PMID 32472577 DOI: 10.1111/Nyas.14371  0.406
2020 Prokopenko D, Hecker J, Kirchner R, Chapman BA, Hoffman O, Mullin K, Hide W, Bertram L, Laird N, DeMeo DL, Lange C, Tanzi RE. Identification of Novel Alzheimer's Disease Loci Using Sex-Specific Family-Based Association Analysis of Whole-Genome Sequence Data. Scientific Reports. 10: 5029. PMID 32193444 DOI: 10.1038/S41598-020-61883-6  0.36
2020 Kwak SS, Washicosky KJ, Brand E, von Maydell D, Aronson J, Kim S, Capen DE, Cetinbas M, Sadreyev R, Ning S, Bylykbashi E, Xia W, Wagner SL, Choi SH, Tanzi RE, et al. Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer's disease. Nature Communications. 11: 1377. PMID 32170138 DOI: 10.1038/S41467-020-15120-3  0.791
2020 Zhang X, Zhang C, Prokopenko D, Liang Y, Han W, Tanzi RE, Sisodia SS. Negative Evidence for a Role of APH1B T27I Variant in Alzheimer's Disease. Human Molecular Genetics. PMID 31995180 DOI: 10.1093/Hmg/Ddaa017  0.385
2020 Prikhodko O, Rynearson KD, Sekhon T, Mante MM, Nguyen PD, Rissman RA, Tanzi RE, Wagner SL. The GSM BPN-15606 as a Potential Candidate for Preventative Therapy in Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 31958080 DOI: 10.3233/Jad-190442  0.454
2019 Wan Y, Liang Y, Liang F, Shen N, Shinozuka K, Yu JT, Ran C, Quan Q, Tanzi RE, Zhang C. A Curcumin Analog Reduces Levels of the Alzheimer's Disease-Associated Amyloid-β Protein by Modulating AβPP Processing and Autophagy. Journal of Alzheimer's Disease : Jad. PMID 31640096 DOI: 10.3233/Jad-190562  0.445
2019 Shin Y, Choi SH, Kim E, Bylykbashi E, Kim JA, Chung S, Kim DY, Kamm RD, Tanzi RE. Blood-Brain Barrier Dysfunction in a 3D In Vitro Model of Alzheimer's Disease. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). 6: 1900962. PMID 31637161 DOI: 10.1002/Advs.201900962  0.768
2019 Huynh TV, Wang C, Tran AC, Tabor GT, Mahan TE, Francis CM, Finn MB, Spellman R, Manis M, Tanzi RE, Ulrich JD, Holtzman DM. Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model. Molecular Neurodegeneration. 14: 37. PMID 31623648 DOI: 10.1186/S13024-019-0337-1  0.453
2019 Liu K, Ma C, Su J, Sun Y, Shen N, Li B, Feng Y, Yang X, Wu H, Zhang H, Herrmann A, Tanzi R, Zhang C. Significant upregulation of Alzheimer's β-amyloid levels in living system induced by extracellular elastin polypeptides. Angewandte Chemie (International Ed. in English). PMID 31609093 DOI: 10.1002/Anie.201912399  0.456
2019 Elmaleh DR, Farlow MR, Conti PS, Tompkins RG, Kundakovic L, Tanzi RE. Developing Effective Alzheimer's Disease Therapies: Clinical Experience and Future Directions. Journal of Alzheimer's Disease : Jad. PMID 31476157 DOI: 10.3233/Jad-190507  0.326
2019 Suh J, Romano DM, Nitschke L, Herrick SP, DiMarzio BA, Dzhala V, Bae JS, Oram MK, Zheng Y, Hooli B, Mullin K, Gennarino VA, Wasco W, Schmahmann JD, Albers MW, ... ... Tanzi RE, et al. Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription. Cell. 178: 1159-1175.e17. PMID 31442405 DOI: 10.1016/J.Ibror.2019.07.707  0.712
2019 Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, ... ... Tanzi RE, et al. Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics. PMID 31417202 DOI: 10.1038/s41588-019-0495-7  0.56
2019 Griciuc A, Patel S, Federico AN, Choi SH, Innes BJ, Oram MK, Cereghetti G, McGinty D, Anselmo A, Sadreyev RI, Hickman SE, El Khoury J, Colonna M, Tanzi RE. TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer's Disease. Neuron. PMID 31301936 DOI: 10.1016/J.Neuron.2019.06.010  0.32
2019 Choi SH, Tanzi RE. Is Alzheimer's Disease a Neurogenesis Disorder? Cell Stem Cell. 25: 7-8. PMID 31271749 DOI: 10.1016/J.Stem.2019.06.001  0.397
2019 Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, ... ... Tanzi RE, et al. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics. 51: 414-430. PMID 30820047 DOI: 10.1038/s41588-019-0358-2  0.559
2019 Hyman B, Tanzi RE. Effects of Species-Specific Genetics on Alzheimer's Mouse Models. Neuron. 101: 351-352. PMID 30731053 DOI: 10.1016/J.Neuron.2019.01.021  0.397
2019 Snow AD, Castillo GM, Nguyen BP, Choi PY, Cummings JA, Cam J, Hu Q, Lake T, Pan W, Kastin AJ, Kirschner DA, Wood SG, Rockenstein E, Masliah E, Lorimer S, ... Tanzi RE, et al. The Amazon rain forest plant Uncaria tomentosa (cat's claw) and its specific proanthocyanidin constituents are potent inhibitors and reducers of both brain plaques and tangles. Scientific Reports. 9: 561. PMID 30728442 DOI: 10.1038/S41598-019-38645-0  0.405
2019 Ning S, Rompala A, Shanmugam NK, Kim I, Rodriguez AS, Hartmann S, Patel SR, Choi SH, Tanzi RE, Kim DY. Rapid removal of amyloid-β aggregates using superparamagnetic nanoparticles Ibro Reports. 6: S378. DOI: 10.1016/J.Ibror.2019.07.1202  0.732
2018 Norambuena A, Wallrabe H, Cao R, Wang DB, Silva A, Svindrych Z, Periasamy A, Hu S, Tanzi RE, Kim DY, Bloom GS. A novel lysosome-to-mitochondria signaling pathway disrupted by amyloid-β oligomers. The Embo Journal. PMID 30348864 DOI: 10.15252/Embj.2018100241  0.762
2018 Moir RD, Lathe R, Tanzi RE. The antimicrobial protection hypothesis of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30314800 DOI: 10.1016/J.Jalz.2018.06.3040  0.447
2018 Choi SH, Bylykbashi E, Chatila ZK, Lee SW, Pulli B, Clemenson GD, Kim E, Rompala A, Oram MK, Asselin C, Aronson J, Zhang C, Miller SJ, Lesinski A, Chen JW, ... ... Tanzi RE, et al. Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model. Science (New York, N.Y.). 361. PMID 30190379 DOI: 10.1126/Science.Aan8821  0.743
2018 Chatila ZK, Kim E, Berlé C, Bylykbashi E, Rompala A, Oram MK, Gupta D, Kwak SS, Kim YH, Kim DY, Choi SH, Tanzi RE. BACE1 Regulates Proliferation and Neuronal Differentiation of Newborn Cells in the Adult Hippocampus in Mice. Eneuro. 5. PMID 30079376 DOI: 10.1523/ENEURO.0067-18.2018  0.739
2018 Eimer WA, Vijaya Kumar DK, Navalpur Shanmugam NK, Rodriguez AS, Mitchell T, Washicosky KJ, György B, Breakefield XO, Tanzi RE, Moir RD. Alzheimer's Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection. Neuron. 99: 56-63.e3. PMID 30001512 DOI: 10.1016/J.Neuron.2018.06.030  0.427
2018 Park J, Wetzel I, Marriott I, Dréau D, D'Avanzo C, Kim DY, Tanzi RE, Cho H. A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer's disease. Nature Neuroscience. PMID 29950669 DOI: 10.1038/S41593-018-0175-4  0.823
2018 Moreno CL, Guardia LD, Shnyder V, Ortiz-Virumbrales M, Kruglikov I, Zhang B, Schadt EE, Tanzi RE, Noggle S, Buettner C, Gandy S. iPSC-derived familial Alzheimer's PSEN2 cholinergic neurons exhibit mutation-dependent molecular pathology corrected by insulin signaling. Molecular Neurodegeneration. 13: 33. PMID 29945658 DOI: 10.1186/S13024-018-0265-5  0.372
2018 Sohn D, Shpanskaya K, Lucas JE, Petrella JR, Saykin AJ, Tanzi RE, Samatova NF, Doraiswamy PM. Sex Differences in Cognitive Decline in Subjects with High Likelihood of Mild Cognitive Impairment due to Alzheimer's disease. Scientific Reports. 8: 7490. PMID 29748598 DOI: 10.1038/S41598-018-25377-W  0.324
2018 Pita-Juarez Y, Altschuler G, Kariotis S, Wei W, Koler K, Green C, Tanzi R, Hide W. The Pathway Coexpression Network: Revealing pathway relationships. Plos Computational Biology. 14: e1006042. PMID 29554099 DOI: 10.1371/Journal.Pcbi.1006042  0.332
2018 Jorfi M, D'Avanzo C, Tanzi RE, Kim DY, Irimia D. Human Neurospheroid Arrays for In Vitro Studies of Alzheimer's Disease. Scientific Reports. 8: 2450. PMID 29402979 DOI: 10.1038/S41598-018-20436-8  0.805
2018 Zhang C, Griciuc A, Hudry E, Wan Y, Quinti L, Ward J, Forte AM, Shen X, Ran C, Elmaleh DR, Tanzi RE. Cromolyn Reduces Levels of the Alzheimer's Disease-Associated Amyloid β-Protein by Promoting Microglial Phagocytosis. Scientific Reports. 8: 1144. PMID 29348604 DOI: 10.1038/S41598-018-19641-2  0.461
2017 Ortiz-Virumbrales M, Moreno CL, Kruglikov I, Marazuela P, Sproul A, Jacob S, Zimmer M, Paull D, Zhang B, Schadt EE, Ehrlich ME, Tanzi RE, Arancio O, Noggle S, Gandy S. CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer's PSEN2 (N141I) neurons. Acta Neuropathologica Communications. 5: 77. PMID 29078805 DOI: 10.1186/S40478-017-0475-Z  0.335
2017 Yang J, Zhang X, Zhu Y, Lenczowski E, Tian Y, Yang J, Zhang C, Hardt M, Qiao C, Tanzi RE, Moore A, Ye H, Ran C. The double-edged role of copper in the fate of amyloid beta in the presence of anti-oxidants. Chemical Science. 8: 6155-6164. PMID 28989646 DOI: 10.1039/C7Sc01787A  0.423
2017 Raven F, Ward JF, Zoltowska KM, Wan Y, Bylykbashi E, Miller SJ, Shen X, Choi SH, Rynearson KD, Berezovska O, Wagner SL, Tanzi RE, Zhang C. Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1. Ebiomedicine. PMID 28919280 DOI: 10.1016/J.Ebiom.2017.08.028  0.447
2017 Minter MR, Hinterleitner R, Meisel M, Zhang C, Leone V, Zhang X, Oyler-Castrillo P, Zhang X, Musch MW, Shen X, Jabri B, Chang EB, Tanzi RE, Sisodia SS. Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer's disease. Scientific Reports. 7: 10411. PMID 28874832 DOI: 10.1038/S41598-017-11047-W  0.407
2017 Liang F, Wan Y, Schaak D, Ward J, Shen X, Tanzi RE, Zhang C, Quan Q. Nanoplasmonic fiber tip probe detects significant reduction of intracellular Alzheimer's disease-related oligomers by curcumin. Scientific Reports. 7: 5722. PMID 28720893 DOI: 10.1038/S41598-017-05619-Z  0.436
2017 Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, ... ... Tanzi RE, et al. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nature Genetics. PMID 28714976 DOI: 10.1038/Ng.3916  0.584
2017 Wagner SL, Rynearson KD, Duddy SK, Zhang C, Nguyen PD, Becker A, Vo U, Masliah D, Monte L, Klee JB, Echmalian CM, Xia W, Quinti L, Johnson G, Lin JH, ... ... Tanzi RE, et al. Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606. The Journal of Pharmacology and Experimental Therapeutics. PMID 28416568 DOI: 10.1124/Jpet.117.240861  0.761
2017 Ward J, Wang H, Saunders AJ, Tanzi RE, Zhang C. Mechanisms that synergistically regulate η-secretase processing of APP and Aη-α protein levels: relevance to pathogenesis and treatment of Alzheimer's disease. Discovery Medicine. 23: 121-128. PMID 28371615  0.309
2017 Li A, Hooli B, Mullin K, Tate RE, Bubnys A, Kirchner R, Chapman B, Hofmann O, Hide W, Tanzi RE. Silencing Of The Drosophila Ortholog Of Sox5 Leads To Abnormal Neuronal Development And Behavioral Impairment. Human Molecular Genetics. PMID 28186563 DOI: 10.1093/Hmg/Ddx051  0.381
2017 Quinti L, Forte AM, Kim DY, Griciuc A, Tanzi RE. A NOVEL DRUG-SCREENING PLATFORM IN MICROGLIAL CELLS IDENTIFIES POTENTIAL AD DRUGS Alzheimer's & Dementia. 13: P1485. DOI: 10.1016/J.Jalz.2017.07.564  0.725
2016 Choi SH, Kim YH, Quinti L, Tanzi RE, Kim DY. 3D culture models of Alzheimer's disease: a road map to a "cure-in-a-dish". Molecular Neurodegeneration. 11: 75. PMID 27938410 DOI: 10.1186/S13024-016-0139-7  0.777
2016 Bhattacharyya R, Fenn RH, Barren C, Tanzi RE, Kovacs DM. Palmitoylated APP Forms Dimers, Cleaved by BACE1. Plos One. 11: e0166400. PMID 27875558 DOI: 10.1371/Journal.Pone.0166400  0.516
2016 Song W, Hooli B, Mullin K, Jin SC, Cella M, Ulland TK, Wang Y, Tanzi R, Colonna M. Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 27520774 DOI: 10.1016/J.Jalz.2016.07.004  0.406
2016 Minter MR, Zhang C, Leone V, Ringus DL, Zhang X, Oyler-Castrillo P, Musch MW, Liao F, Ward JF, Holtzman DM, Chang EB, Tanzi RE, Sisodia SS. Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease. Scientific Reports. 6: 30028. PMID 27443609 DOI: 10.1038/Srep30028  0.406
2016 Kumar DK, Choi SH, Washicosky KJ, Eimer WA, Tucker S, Ghofrani J, Lefkowitz A, McColl G, Goldstein LE, Tanzi RE, Moir RD. Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer's disease. Science Translational Medicine. 8: 340ra72. PMID 27225182 DOI: 10.1126/Scitranslmed.Aaf1059  0.421
2016 Alfonso SI, Callender JA, Hooli B, Antal CE, Mullin K, Sherman MA, Lesné SE, Leitges M, Newton AC, Tanzi RE, Malinow R. Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer's disease. Science Signaling. 9: ra47. PMID 27165780 DOI: 10.1126/Scisignal.Aaf6209  0.425
2016 Newton AC, Tanzi RE, VanHook AM. Science Signaling Podcast for 10 May 2016: PKCα in Alzheimer's disease. Science Signaling. 9: pc11. PMID 27165779 DOI: 10.1126/Scisignal.Aaf9436  0.427
2016 Bettayeb K, Hooli BV, Parrado AR, Randolph L, Varotsis D, Aryal S, Gresack J, Tanzi RE, Greengard P, Flajolet M. Relevance of the COPI complex for Alzheimer's disease progression in vivo. Proceedings of the National Academy of Sciences of the United States of America. PMID 27114526 DOI: 10.1073/Pnas.1604176113  0.454
2016 Kim BM, You MH, Chen CH, Suh J, Tanzi RE, Lee TH. Inhibition of Death-associated Protein Kinase 1 Attenuates the Phosphorylation and Amyloidogenic Processing of Amyloid Precursor Protein. Human Molecular Genetics. PMID 27094130 DOI: 10.1093/Hmg/Ddw114  0.462
2016 Herold C, Hooli BV, Mullin K, Liu T, Roehr JT, Mattheisen M, Parrado AR, Bertram L, Lange C, Tanzi RE. Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer's disease with OSBPL6, PTPRG, and PDCL3. Molecular Psychiatry. PMID 26830138 DOI: 10.1038/Mp.2015.218  0.323
2016 Villemagne VL, Rowe CC, Barnham KJ, Cherny R, Woodward M, Pejoska S, Salvado O, Bourgeat P, Perez K, Fowler C, Rembach A, Maruff P, Tanzi R, Ritchie CW, Masters CL. P1-042: An Exploratory Molecular Imaging Study Targeting Aβ with A Novel 8-OH Quinoline in Alzheimer’s Disease (The PBT2-204 Imagine Study) Alzheimer's & Dementia. 12: P417-P417. DOI: 10.1016/J.Jalz.2016.06.789  0.404
2016 Tanzi R, Kim DY. EC-03-01: Reconstructing Alzheimer Amyloid and Tau Pathology in 3D Cell Cultures from Stem Cells Alzheimer's & Dementia. 12: P268-P269. DOI: 10.1016/J.Jalz.2016.06.485  0.757
2015 Choi SH, Kim YH, D'Avanzo C, Aronson J, Tanzi RE, Kim DY. Recapitulating amyloid β and tau pathology in human neural cell culture models: clinical implications. Us Neurology. 11: 102-105. PMID 27019672 DOI: 10.17925/Usn.2015.11.02.102  0.778
2015 Hyman BT, Growdon JH, Albers MW, Buckner RL, Chhatwal J, Gomez-Isla MT, Haass C, Hudry E, Jack CR, Johnson KA, Khachaturian ZS, Kim DY, Martin JB, Nitsch RM, Rosen BR, ... ... Tanzi RE, et al. Massachusetts Alzheimer's Disease Research Center: Progress and challenges. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26297855 DOI: 10.1016/J.Jalz.2015.06.1887  0.752
2015 D'Avanzo C, Aronson J, Kim YH, Choi SH, Tanzi RE, Kim DY. Alzheimer's in 3D culture: Challenges and perspectives. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 37: 1139-48. PMID 26252541 DOI: 10.1002/Bies.201500063  0.778
2015 Gautam V, D'Avanzo C, Berezovska O, Tanzi RE, Kovacs DM. Synaptotagmins interact with APP and promote Aβ generation. Molecular Neurodegeneration. 10: 31. PMID 26202512 DOI: 10.1186/S13024-015-0028-5  0.603
2015 Zhang X, Tian Y, Zhang C, Tian X, Ross AW, Moir RD, Sun H, Tanzi RE, Moore A, Ran C. Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 26199414 DOI: 10.1073/Pnas.1505420112  0.408
2015 Kim YH, Choi SH, D'Avanzo C, Hebisch M, Sliwinski C, Bylykbashi E, Washicosky KJ, Klee JB, Brüstle O, Tanzi RE, Kim DY. A 3D human neural cell culture system for modeling Alzheimer's disease. Nature Protocols. 10: 985-1006. PMID 26068894 DOI: 10.1038/Nprot.2015.065  0.782
2015 Wang H, Sang N, Zhang C, Raghupathi R, Tanzi RE, Saunders A. Cathepsin L Mediates the Degradation of Novel APP C-Terminal Fragments. Biochemistry. 54: 2806-16. PMID 25910068 DOI: 10.1021/Acs.Biochem.5B00329  0.395
2015 D'Avanzo C, Sliwinski C, Wagner SL, Tanzi RE, Kim DY, Kovacs DM. γ-Secretase modulators reduce endogenous amyloid β42 levels in human neural progenitor cells without altering neuronal differentiation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 25903103 DOI: 10.1096/fj.15-271015  0.782
2015 Hooli BV, Lill CM, Mullin K, Qiao D, Lange C, Bertram L, Tanzi RE. PLD3 gene variants and Alzheimer's disease. Nature. 520: E7-8. PMID 25832413 DOI: 10.1038/Nature14040  0.391
2015 Weissmiller AM, Natera-Naranjo O, Reyna SM, Pearn ML, Zhao X, Nguyen P, Cheng S, Goldstein LS, Tanzi RE, Wagner SL, Mobley WC, Wu C. A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP. Plos One. 10: e0118379. PMID 25710492 DOI: 10.1371/Journal.Pone.0118379  0.377
2015 Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, ... ... Tanzi RE, et al. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. Jama Neurology. 72: 209-16. PMID 25531812 DOI: 10.1001/Jamaneurol.2014.2157  0.417
2014 Choi SH, Kim YH, Hebisch M, Sliwinski C, Lee S, D'Avanzo C, Chen H, Hooli B, Asselin C, Muffat J, Klee JB, Zhang C, Wainger BJ, Peitz M, Kovacs DM, ... ... Tanzi RE, et al. A three-dimensional human neural cell culture model of Alzheimer's disease. Nature. 515: 274-8. PMID 25307057 DOI: 10.1038/Nature13800  0.82
2014 Liu Q, Waltz S, Woodruff G, Ouyang J, Israel MA, Herrera C, Sarsoza F, Tanzi RE, Koo EH, Ringman JM, Goldstein LS, Wagner SL, Yuan SH. Effect of potent γ-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers. Jama Neurology. 71: 1481-9. PMID 25285942 DOI: 10.1001/Jamaneurol.2014.2482  0.331
2014 Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, ... ... Tanzi RE, et al. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. Jama Neurology. 71: 1394-404. PMID 25199842 DOI: 10.1001/Jamaneurol.2014.1491  0.337
2014 Hooli BV, Parrado AR, Mullin K, Yip WK, Liu T, Roehr JT, Qiao D, Jessen F, Peters O, Becker T, Ramirez A, Lange C, Bertram L, Tanzi RE. The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk. Neurology. 83: 1353-8. PMID 25186855 DOI: 10.1212/Wnl.0000000000000855  0.389
2014 Veeraraghavalu K, Zhang C, Zhang X, Tanzi RE, Sisodia SS. Age-dependent, non-cell-autonomous deposition of amyloid from synthesis of β-amyloid by cells other than excitatory neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 3668-73. PMID 24599465 DOI: 10.1523/Jneurosci.5079-13.2014  0.384
2014 Xu Z, Dong Y, Wang H, Culley DJ, Marcantonio ER, Crosby G, Tanzi RE, Zhang Y, Xie Z. Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice. Scientific Reports. 4: 3766. PMID 24441878 DOI: 10.1038/Srep03766  0.323
2014 Wagner SL, Zhang C, Cheng S, Nguyen P, Zhang X, Rynearson KD, Wang R, Li Y, Sisodia SS, Mobley WC, Tanzi RE. Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species. Biochemistry. 53: 702-13. PMID 24401146 DOI: 10.1021/Bi401537V  0.391
2014 Hooli BV, Kovacs-Vajna ZM, Mullin K, Blumenthal MA, Mattheisen M, Zhang C, Lange C, Mohapatra G, Bertram L, Tanzi RE. Rare autosomal copy number variations in early-onset familial Alzheimer's disease. Molecular Psychiatry. 19: 676-81. PMID 23752245 DOI: 10.1038/Mp.2013.77  0.426
2013 Suh J, Choi SH, Romano DM, Gannon MA, Lesinski AN, Kim DY, Tanzi RE. ADAM10 missense mutations potentiate β-amyloid accumulation by impairing prodomain chaperone function. Neuron. 80: 385-401. PMID 24055016 DOI: 10.1016/J.Neuron.2013.08.035  0.767
2013 Veeraraghavalu K, Zhang C, Miller S, Hefendehl JK, Rajapaksha TW, Ulrich J, Jucker M, Holtzman DM, Tanzi RE, Vassar R, Sisodia SS. Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models". Science (New York, N.Y.). 340: 924-f. PMID 23704555 DOI: 10.1126/Science.1235505  0.431
2013 Li A, Ahsen OO, Liu JJ, Du C, McKee ML, Yang Y, Wasco W, Newton-Cheh CH, O'Donnell CJ, Fujimoto JG, Zhou C, Tanzi RE. Silencing of the Drosophila ortholog of SOX5 in heart leads to cardiac dysfunction as detected by optical coherence tomography. Human Molecular Genetics. 22: 3798-806. PMID 23696452 DOI: 10.1093/Hmg/Ddt230  0.609
2013 Griciuc A, Serrano-Pozo A, Parrado AR, Lesinski AN, Asselin CN, Mullin K, Hooli B, Choi SH, Hyman BT, Tanzi RE. Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta. Neuron. 78: 631-43. PMID 23623698 DOI: 10.1016/J.Neuron.2013.04.014  0.363
2013 Yun SM, Cho SJ, Song JC, Song SY, Jo SA, Jo C, Yoon K, Tanzi RE, Choi EJ, Koh YH. SUMO1 modulates Aβ generation via BACE1 accumulation. Neurobiology of Aging. 34: 650-62. PMID 22975420 DOI: 10.1016/J.Neurobiolaging.2012.08.005  0.438
2013 Craddock TJA, Tuszynski JA, Chopra D, Casey N, Goldstein LE, Hameroff SR, Tanzi RE. Correction: The zinc dyshomeostasis hypothesis of Alzheimer's disease (PLos ONE) Plos One. 8. DOI: 10.1371/Annotation/E83Fbf22-647F-496F-B27D-5Aff26898083  0.401
2013 Schjeide B, Borovecki F, Clarimón J, Faltraco F, Giedraitis V, Ingelsson M, Hampel H, Hooli B, Kilander L, Kirchheiner J, Klepac N, Kurz A, Lannfelt L, Lill C, Lleó A, ... ... Tanzi R, et al. Assessment of Alzheimer's disease risk genes with CSF-biomarker levels Alzheimers & Dementia. 9: 179. DOI: 10.1016/J.Jalz.2013.05.294  0.349
2013 Kim YH, Choi SH, Wagner S, Tanzi R, Kim DY. P4-015: A novel Alzheimer's disease model based on 3D-cultured human neural progenitor cells Alzheimer's & Dementia. 9: P710-P710. DOI: 10.1016/J.Jalz.2013.05.1403  0.75
2012 Xie Z, Dong Y, Maeda U, Xia W, Tanzi RE. RNAi-mediated knock-down of Dab and Numb attenuate Aβ levels via γ-secretase mediated APP processing. Translational Neurodegeneration. 1: 8. PMID 23211096 DOI: 10.1186/2047-9158-1-8  0.441
2012 Wagner SL, Tanzi RE, Mobley WC, Galasko D. Potential use of γ-secretase modulators in the treatment of Alzheimer disease. Archives of Neurology. 69: 1255-8. PMID 22801784 DOI: 10.1001/Archneurol.2012.540  0.348
2012 Hooli BV, Mohapatra G, Mattheisen M, Parrado AR, Roehr JT, Shen Y, Gusella JF, Moir R, Saunders AJ, Lange C, Tanzi RE, Bertram L. Role of common and rare APP DNA sequence variants in Alzheimer disease. Neurology. 78: 1250-7. PMID 22491860 DOI: 10.1212/Wnl.0B013E3182515972  0.573
2012 Craddock TJ, Tuszynski JA, Chopra D, Casey N, Goldstein LE, Hameroff SR, Tanzi RE. The zinc dyshomeostasis hypothesis of Alzheimer's disease. Plos One. 7: e33552. PMID 22457776 DOI: 10.1371/Journal.Pone.0033552  0.449
2012 Choi SH, Tanzi RE. iPSCs to the rescue in Alzheimer's research. Cell Stem Cell. 10: 235-6. PMID 22385650 DOI: 10.1016/J.Stem.2012.02.011  0.385
2012 Zhang Y, Xu Z, Wang H, Dong Y, Shi HN, Culley DJ, Crosby G, Marcantonio ER, Tanzi RE, Xie Z. Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory. Annals of Neurology. 71: 687-98. PMID 22368036 DOI: 10.1002/Ana.23536  0.316
2012 Wu X, Lu Y, Dong Y, Zhang G, Zhang Y, Xu Z, Culley DJ, Crosby G, Marcantonio ER, Tanzi RE, Xie Z. The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-α, IL-6, and IL-1β. Neurobiology of Aging. 33: 1364-78. PMID 21190757 DOI: 10.1016/J.Neurobiolaging.2010.11.002  0.325
2012 Craddock TJA, Tuszynski JA, Chopra D, Casey N, Goldstein LE, Hameroff SR, Tanzi RE. Correction: The Zinc Dyshomeostasis Hypothesis of Alzheimer's Disease Plos One. 7. DOI: 10.1371/Annotation/57C710A6-83Ba-444C-A352-B9F60125F2Fa  0.308
2011 Zhang Y, Zhen Y, Dong Y, Xu Z, Yue Y, Golde TE, Tanzi RE, Moir RD, Xie Z. Anesthetic propofol attenuates the isoflurane-induced caspase-3 activation and Aβ oligomerization. Plos One. 6: e27019. PMID 22069482 DOI: 10.1371/Journal.Pone.0027019  0.372
2011 Treusch S, Hamamichi S, Goodman JL, Matlack KE, Chung CY, Baru V, Shulman JM, Parrado A, Bevis BJ, Valastyan JS, Han H, Lindhagen-Persson M, Reiman EM, Evans DA, Bennett DA, ... ... Tanzi RE, et al. Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast. Science (New York, N.Y.). 334: 1241-5. PMID 22033521 DOI: 10.1126/Science.1213210  0.406
2011 Li A, Zhou C, Moore J, Zhang P, Tsai TH, Lee HC, Romano DM, McKee ML, Schoenfeld DA, Serra MJ, Raygor K, Cantiello HF, Fujimoto JG, Tanzi RE. Changes in the expression of the Alzheimer’s disease-associated presenilin gene in drosophila heart leads to cardiac dysfunction. Current Alzheimer Research. 8: 313-22. PMID 21524270 DOI: 10.2174/156720511795563746  0.308
2011 Sarajärvi T, Tuusa JT, Haapasalo A, Lackman JJ, Sormunen R, Helisalmi S, Roehr JT, Parrado AR, Mäkinen P, Bertram L, Soininen H, Tanzi RE, Petäjä-Repo UE, Hiltunen M. Cysteine 27 variant of the delta-opioid receptor affects amyloid precursor protein processing through altered endocytic trafficking. Molecular and Cellular Biology. 31: 2326-40. PMID 21464208 DOI: 10.1128/Mcb.05015-11  0.417
2011 Schjeide BM, Schnack C, Lambert JC, Lill CM, Kirchheiner J, Tumani H, Otto M, Tanzi RE, Lehrach H, Amouyel P, von Arnim CA, Bertram L. The role of clusterin, complement receptor 1, and phosphatidylinositol binding clathrin assembly protein in Alzheimer disease risk and cerebrospinal fluid biomarker levels. Archives of General Psychiatry. 68: 207-13. PMID 21300948 DOI: 10.1001/Archgenpsychiatry.2010.196  0.361
2011 Viswanathan J, Haapasalo A, Böttcher C, Miettinen R, Kurkinen KM, Lu A, Thomas A, Maynard CJ, Romano D, Hyman BT, Berezovska O, Bertram L, Soininen H, Dantuma NP, Tanzi RE, et al. Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation. Traffic (Copenhagen, Denmark). 12: 330-48. PMID 21143716 DOI: 10.1111/J.1600-0854.2010.01149.X  0.455
2011 Hooli B, Bertram L, Parrado A, Tanzi R, Mullin K, Gotta L. RETRACTED: Genome-wide assessment of copy number variations in early-onset Alzheimer's disease Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.228  0.345
2010 Norstrom EM, Zhang C, Tanzi R, Sisodia SS. Identification of NEEP21 as a ß-amyloid precursor protein-interacting protein in vivo that modulates amyloidogenic processing in vitro. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 15677-85. PMID 21084623 DOI: 10.1523/Jneurosci.4464-10.2010  0.412
2010 Lane RF, Raines SM, Steele JW, Ehrlich ME, Lah JA, Small SA, Tanzi RE, Attie AD, Gandy S. Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 13110-5. PMID 20881129 DOI: 10.1523/Jneurosci.3872-10.2010  0.455
2010 Zhang C, Browne A, Divito JR, Stevenson JA, Romano D, Dong Y, Xie Z, Tanzi RE. Amyloid-β production via cleavage of amyloid-β protein precursor is modulated by cell density. Journal of Alzheimer's Disease : Jad. 22: 683-984. PMID 20847415 DOI: 10.3233/Jad-2010-100816  0.448
2010 Lambert JC, Sleegers K, González-Pérez A, Ingelsson M, Beecham GW, Hiltunen M, Combarros O, Bullido MJ, Brouwers N, Bettens K, Berr C, Pasquier F, Richard F, Dekosky ST, Hannequin D, ... ... Tanzi RE, et al. The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study. Journal of Alzheimer's Disease : Jad. 22: 247-55. PMID 20847397 DOI: 10.3233/Jad-2010-100933  0.395
2010 Kounnas MZ, Danks AM, Cheng S, Tyree C, Ackerman E, Zhang X, Ahn K, Nguyen P, Comer D, Mao L, Yu C, Pleynet D, Digregorio PJ, Velicelebi G, Stauderman KA, ... ... Tanzi RE, et al. Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease. Neuron. 67: 769-80. PMID 20826309 DOI: 10.1016/J.Neuron.2010.08.018  0.448
2010 Duce JA, Tsatsanis A, Cater MA, James SA, Robb E, Wikhe K, Leong SL, Perez K, Johanssen T, Greenough MA, Cho HH, Galatis D, Moir RD, Masters CL, McLean C, ... Tanzi RE, et al. Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease. Cell. 142: 857-67. PMID 20817278 DOI: 10.1016/J.Cell.2010.08.014  0.613
2010 Zhang C, Browne A, Child D, Tanzi RE. Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein. The Journal of Biological Chemistry. 285: 28472-80. PMID 20622013 DOI: 10.1074/Jbc.M110.133520  0.443
2010 Moncaster JA, Pineda R, Moir RD, Lu S, Burton MA, Ghosh JG, Ericsson M, Soscia SJ, Mocofanescu A, Folkerth RD, Robb RM, Kuszak JR, Clark JI, Tanzi RE, Hunter DG, et al. Alzheimer's disease amyloid-beta links lens and brain pathology in Down syndrome. Plos One. 5: e10659. PMID 20502642 DOI: 10.1371/Journal.Pone.0010659  0.475
2010 Suh J, Im DS, Moon GJ, Ryu KS, de Silva R, Choi IS, Lees AJ, Guénette SY, Tanzi RE, Gwag BJ. Hypoxic ischemia and proteasome dysfunction alter tau isoform ratio by inhibiting exon 10 splicing. Journal of Neurochemistry. 114: 160-70. PMID 20374429 DOI: 10.1111/J.1471-4159.2010.06732.X  0.318
2010 Soscia SJ, Kirby JE, Washicosky KJ, Tucker SM, Ingelsson M, Hyman B, Burton MA, Goldstein LE, Duong S, Tanzi RE, Moir RD. The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide. Plos One. 5: e9505. PMID 20209079 DOI: 10.1371/Journal.Pone.0009505  0.447
2010 Zhang C, Browne A, Kim DY, Tanzi RE. Familial Alzheimer's disease mutations in presenilin 1 do not alter levels of the secreted amyloid-beta protein precursor generated by beta-secretase cleavage. Current Alzheimer Research. 7: 21-6. PMID 20205669 DOI: 10.2174/156720510790274428  0.772
2010 Gianni D, Li A, Tesco G, McKay KM, Moore J, Raygor K, Rota M, Gwathmey JK, Dec GW, Aretz T, Leri A, Semigran MJ, Anversa P, Macgillivray TE, Tanzi RE, et al. Protein aggregates and novel presenilin gene variants in idiopathic dilated cardiomyopathy. Circulation. 121: 1216-26. PMID 20194882 DOI: 10.1161/Circulationaha.109.879510  0.331
2010 Faux NG, Ritchie CW, Gunn A, Rembach A, Tsatsanis A, Bedo J, Harrison J, Lannfelt L, Blennow K, Zetterberg H, Ingelsson M, Masters CL, Tanzi RE, Cummings JL, Herd CM, et al. PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses. Journal of Alzheimer's Disease : Jad. 20: 509-16. PMID 20164561 DOI: 10.3233/Jad-2010-1390  0.585
2010 Zhang C, Browne A, Child D, Divito JR, Stevenson JA, Tanzi RE. Loss of function of ATXN1 increases amyloid beta-protein levels by potentiating beta-secretase processing of beta-amyloid precursor protein. The Journal of Biological Chemistry. 285: 8515-26. PMID 20097758 DOI: 10.1074/Jbc.M109.079079  0.47
2010 Pihlajamäki M, O' Keefe K, Bertram L, Tanzi RE, Dickerson BC, Blacker D, Albert MS, Sperling RA. Evidence of altered posteromedial cortical FMRI activity in subjects at risk for Alzheimer disease. Alzheimer Disease and Associated Disorders. 24: 28-36. PMID 19571734 DOI: 10.1097/Wad.0B013E3181A785C9  0.329
2010 Goldstein LE, Moir RD, Mocofanescu A, Fu L, Lu S, Burton MA, Xu W, Ericsson M, Rogers J, Chadwick O, Sadowski M, Wisniewski T, Klunk WE, Mathis CA, Clark JI, ... Tanzi RE, et al. P4-011: In vivo Detection of Early Alzheimer's Disease-Linked Aβ Peptide Accumulation in the Lens by Non-Invasive Quasi-Elastic Light Scattering Alzheimer's & Dementia. 6: e23-e23. DOI: 10.1016/J.Jalz.2010.08.071  0.365
2010 Lane RF, Raines SM, Levey A, Lah JJ, Small SA, Tanzi RE, Attie AD, Gandy SE. Diabetes-linked SORCS1, a gamma-secretase substrate and regulator of Alzheimer APP metabolism, forms complexes with multiple Alzheimer-linked proteins (APP, PS1, BACE, VPS35, and SORLA) Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.814  0.377
2009 Hooli BV, Tanzi RE. A current view of Alzheimer's disease. F1000 Biology Reports. 1: 54. PMID 20948630 DOI: 10.3410/B1-54  0.412
2009 Weiss LA, Arking DE, Daly MJ, Chakravarti A, Brune CW, West K, O'Connor A, Hilton G, Tomlinson RL, West AB, Cook EH, Green T, Chang SC, Gabriel S, Gates C, ... ... Tanzi R, et al. A genome-wide linkage and association scan reveals novel loci for autism Nature. 461: 802-808. PMID 19812673 DOI: 10.1038/Nature08490  0.464
2009 Kim M, Suh J, Romano D, Truong MH, Mullin K, Hooli B, Norton D, Tesco G, Elliott K, Wagner SL, Moir RD, Becker KD, Tanzi RE. Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity. Human Molecular Genetics. 18: 3987-96. PMID 19608551 DOI: 10.1093/Hmg/Ddp323  0.412
2009 Dong Y, Zhang G, Zhang B, Moir RD, Xia W, Marcantonio ER, Culley DJ, Crosby G, Tanzi RE, Xie Z. The common inhalational anesthetic sevoflurane induces apoptosis and increases beta-amyloid protein levels. Archives of Neurology. 66: 620-31. PMID 19433662 DOI: 10.1001/Archneurol.2009.48  0.386
2009 Schjeide BM, Hooli B, Parkinson M, Hogan MF, DiVito J, Mullin K, Blacker D, Tanzi RE, Bertram L. GAB2 as an Alzheimer disease susceptibility gene: follow-up of genomewide association results. Archives of Neurology. 66: 250-4. PMID 19204163 DOI: 10.1001/Archneurol.2008.552  0.404
2009 Myre MA, Washicosky K, Moir RD, Tesco G, Tanzi RE, Wasco W. Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1. Cellular Signalling. 21: 567-76. PMID 19154786 DOI: 10.1016/J.Cellsig.2008.12.008  0.815
2009 Lu A, Hiltunen M, Romano DM, Soininen H, Hyman BT, Bertram L, Tanzi RE. Effects of ubiquilin 1 on the unfolded protein response. Journal of Molecular Neuroscience : Mn. 38: 19-30. PMID 18953672 DOI: 10.1007/S12031-008-9155-6  0.362
2009 Schjeide BM, McQueen MB, Mullin K, DiVito J, Hogan MF, Parkinson M, Hooli B, Lange C, Blacker D, Tanzi RE, Bertram L. Assessment of Alzheimer's disease case-control associations using family-based methods. Neurogenetics. 10: 19-25. PMID 18830724 DOI: 10.1007/S10048-008-0151-3  0.393
2009 Bush AI, Cherny RA, Finkelstein D, Masters CL, Tanzi RE, Barnham KJ, Ritchie C, Adlard PA. S4-04-05: Pbt2 for Pre-dementia Alzheimer's Disease: Animal and Clinical Evidence Alzheimer's & Dementia. 5: e5-e5. DOI: 10.1016/J.Jalz.2009.07.132  0.531
2008 Bertram L, Schjeide BM, Hooli B, Mullin K, Hiltunen M, Soininen H, Ingelsson M, Lannfelt L, Blacker D, Tanzi RE. No association between CALHM1 and Alzheimer's disease risk. Cell. 135: 993-4; author reply . PMID 19070563 DOI: 10.1016/J.Cell.2008.11.030  0.358
2008 Xie Z, Culley DJ, Dong Y, Zhang G, Zhang B, Moir RD, Frosch MP, Crosby G, Tanzi RE. The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta-protein level in vivo. Annals of Neurology. 64: 618-27. PMID 19006075 DOI: 10.1002/Ana.21548  0.42
2008 Bertram L, Lange C, Mullin K, Parkinson M, Hsiao M, Hogan MF, Schjeide BM, Hooli B, Divito J, Ionita I, Jiang H, Laird N, Moscarillo T, Ohlsen KL, Elliott K, ... ... Tanzi RE, et al. Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. American Journal of Human Genetics. 83: 623-32. PMID 18976728 DOI: 10.1016/J.Ajhg.2008.10.008  0.383
2008 Schaffer BA, Bertram L, Miller BL, Mullin K, Weintraub S, Johnson N, Bigio EH, Mesulam M, Wiedau-Pazos M, Jackson GR, Cummings JL, Cantor RM, Levey AI, Tanzi RE, Geschwind DH. Association of GSK3B with Alzheimer disease and frontotemporal dementia. Archives of Neurology. 65: 1368-74. PMID 18852354 DOI: 10.1001/Archneur.65.10.1368  0.414
2008 Bush AI, Tanzi RE. Therapeutics for Alzheimer's disease based on the metal hypothesis. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 5: 421-32. PMID 18625454 DOI: 10.1016/J.Nurt.2008.05.001  0.452
2008 Adlard PA, Cherny RA, Finkelstein DI, Gautier E, Robb E, Cortes M, Volitakis I, Liu X, Smith JP, Perez K, Laughton K, Li QX, Charman SA, Nicolazzo JA, Wilkins S, ... ... Tanzi RE, et al. Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta. Neuron. 59: 43-55. PMID 18614028 DOI: 10.1016/J.Neuron.2008.06.018  0.642
2008 Zhang B, Dong Y, Zhang G, Moir RD, Xia W, Yue Y, Tian M, Culley DJ, Crosby G, Tanzi RE, Xie Z. The inhalation anesthetic desflurane induces caspase activation and increases amyloid beta-protein levels under hypoxic conditions. The Journal of Biological Chemistry. 283: 11866-75. PMID 18326038 DOI: 10.1074/Jbc.M800199200  0.402
2008 Smith EE, Egorova S, Blacker D, Killiany RJ, Muzikansky A, Dickerson BC, Tanzi RE, Albert MS, Greenberg SM, Guttmann CR. Magnetic resonance imaging white matter hyperintensities and brain volume in the prediction of mild cognitive impairment and dementia. Archives of Neurology. 65: 94-100. PMID 18195145 DOI: 10.1001/Archneurol.2007.23  0.304
2008 Weiss LA, Shen Y, Korn JM, Arking DE, Miller DT, Fossdal R, Saemundsen E, Stefansson H, Ferreira MA, Green T, Platt OS, Ruderfer DM, Walsh CA, Altshuler D, Chakravarti A, ... Tanzi RE, et al. Association between microdeletion and microduplication at 16p11.2 and autism. The New England Journal of Medicine. 358: 667-75. PMID 18184952 DOI: 10.1056/Nejmoa075974  0.457
2008 Moncaster JA, Moir RD, Mocofanescu AG, Burton MA, Ghosh J, Ericsson M, Rogers JT, Klunk WE, Mathis CA, Sadowski M, Wisniewski T, Clark JI, Tanzi RE, Goldstein LE. P1-379: In vivo detection of Alzheimer's disease–linked Aβ peptide accumulation in the lens Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.961  0.373
2008 Duce JA, Rogers JT, Tsatsanis A, Moir RD, Robb E, Leong SL, Harding SM, Venti A, Masters C, Cappai R, Tanzi RE, Bush AI. P3-325: Alzheimer's disease β-amyloid protein precursor is ferroxidase II, a ceruloplasmin-like iron detoxification enzyme Alzheimer's & Dementia. 4: T617-T617. DOI: 10.1016/J.Jalz.2008.05.1894  0.601
2008 Schjeide BM, McQueen MB, Mullin K, Divito J, Hogan MF, Parkinson M, Blacker D, Tanzi RE, Bertram L. P3-262: Assessment of Alzheimer's disease case-control association findings in a large collection of family-based samples Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.1830  0.335
2007 Hamshere ML, Holmans PA, Avramopoulos D, Bassett SS, Blacker D, Bertram L, Wiener H, Rochberg N, Tanzi RE, Myers A, Wavrant-De Vrièze F, Go R, Fallin D, Lovestone S, Hardy J, et al. Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease. Human Molecular Genetics. 16: 2703-12. PMID 17725986 DOI: 10.1093/Hmg/Ddm224  0.303
2007 Zhang C, Khandelwal PJ, Chakraborty R, Cuellar TL, Sarangi S, Patel SA, Cosentino CP, O'Connor M, Lee JC, Tanzi RE, Saunders AJ. An AICD-based functional screen to identify APP metabolism regulators. Molecular Neurodegeneration. 2: 15. PMID 17718916 DOI: 10.1186/1750-1326-2-15  0.396
2007 Li A, Xie Z, Dong Y, McKay KM, McKee ML, Tanzi RE. Isolation and characterization of the Drosophila ubiquilin ortholog dUbqln: in vivo interaction with early-onset Alzheimer disease genes. Human Molecular Genetics. 16: 2626-39. PMID 17704509 DOI: 10.1093/Hmg/Ddm219  0.417
2007 Huttunen HJ, Guénette SY, Peach C, Greco C, Xia W, Kim DY, Barren C, Tanzi RE, Kovacs DM. HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation. The Journal of Biological Chemistry. 282: 28285-95. PMID 17684015 DOI: 10.1074/Jbc.M702951200  0.799
2007 McQueen MB, Bertram L, Lange C, Becker KD, Albert MS, Tanzi RE, Blacker D. Exploring candidate gene associations with neuropsychological performance. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 144: 987-91. PMID 17579348 DOI: 10.1002/Ajmg.B.30500  0.358
2007 Tesco G, Koh YH, Kang EL, Cameron AN, Das S, Sena-Esteves M, Hiltunen M, Yang SH, Zhong Z, Shen Y, Simpkins JW, Tanzi RE. Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity. Neuron. 54: 721-37. PMID 17553422 DOI: 10.1016/J.Neuron.2007.05.012  0.408
2007 Xie Z, Dong Y, Maeda U, Moir RD, Xia W, Culley DJ, Crosby G, Tanzi RE. The inhalation anesthetic isoflurane induces a vicious cycle of apoptosis and amyloid beta-protein accumulation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 1247-54. PMID 17287498 DOI: 10.1523/Jneurosci.5320-06.2007  0.376
2007 Kim M, Hersh LB, Leissring MA, Ingelsson M, Matsui T, Farris W, Lu A, Hyman BT, Selkoe DJ, Bertram L, Tanzi RE. Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families. The Journal of Biological Chemistry. 282: 7825-32. PMID 17244626 DOI: 10.1074/Jbc.M609168200  0.413
2007 Bertram L, McQueen MB, Mullin K, Blacker D, Tanzi RE. Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nature Genetics. 39: 17-23. PMID 17192785 DOI: 10.1038/Ng1934  0.362
2007 Xie Z, Dong Y, Maeda U, Xia W, Tanzi RE. RNA interference silencing of the adaptor molecules ShcC and Fe65 differentially affect amyloid precursor protein processing and Abeta generation. The Journal of Biological Chemistry. 282: 4318-25. PMID 17170108 DOI: 10.1074/Jbc.M609293200  0.41
2007 Perry RT, Wiener H, Harrell LE, Blacker D, Tanzi RE, Bertram L, Bassett SS, Go RC. Follow-up mapping supports the evidence for linkage in the candidate region at 9q22 in the NIMH Alzheimer's disease Genetics Initiative cohort. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 144: 220-7. PMID 17034007 DOI: 10.1002/Ajmg.B.30433  0.356
2007 Bertram L, Hsiao M, McQueen MB, Parkinson M, Mullin K, Blacker D, Tanzi RE. The LDLR locus in Alzheimer's disease: a family-based study and meta-analysis of case-control data. Neurobiology of Aging. 28: 18.e1-4. PMID 16378661 DOI: 10.1016/J.Neurobiolaging.2005.11.005  0.381
2007 Moncaster J, Moir RD, Fu L, Mocofanescu A, Lu S, Xu W, Chadwick O, Rogers JT, Sadowski M, Wisniewski T, Klunk WE, Mathis CA, Clark JI, Tanzi RE, Goldstein LE. O2-03-05: Early detection of Alzheimer's disease-linked aβ peptide accumulation in the lens by non-invasive quasi-elastic light scattering Alzheimer's & Dementia. 3: S190-S190. DOI: 10.1016/J.Jalz.2007.04.030  0.356
2006 Xie Z, Dong Y, Maeda U, Moir R, Inouye SK, Culley DJ, Crosby G, Tanzi RE. Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 61: 1300-6. PMID 17234824 DOI: 10.1093/Gerona/61.12.1300  0.377
2006 Hiltunen M, Lu A, Thomas AV, Romano DM, Kim M, Jones PB, Xie Z, Kounnas MZ, Wagner SL, Berezovska O, Hyman BT, Tesco G, Bertram L, Tanzi RE. Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion. The Journal of Biological Chemistry. 281: 32240-53. PMID 16945923 DOI: 10.1074/Jbc.M603106200  0.411
2006 Romano DM, Dong Y, Hiltunen M, Tanzi RE, Xie Z. Artefactual effects of lipid-based cell transfection reagents on AbetaPP processing and Abeta production. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 13: 86-92. PMID 16911962 DOI: 10.1080/13506120600722605  0.4
2006 Thomas AV, Herl L, Spoelgen R, Hiltunen M, Jones PB, Tanzi RE, Hyman BT, Berezovska O. Interaction between presenilin 1 and ubiquilin 1 as detected by fluorescence lifetime imaging microscopy and a high-throughput fluorescent plate reader. The Journal of Biological Chemistry. 281: 26400-7. PMID 16815845 DOI: 10.1074/Jbc.M601085200  0.394
2006 Bertram L, Hsiao M, Lange C, Blacker D, Tanzi RE. Single-nucleotide polymorphism rs498055 on chromosome 10q24 is not associated with Alzheimer disease in two independent family samples. American Journal of Human Genetics. 79: 180-3; author reply . PMID 16773580 DOI: 10.1086/505032  0.322
2006 Xie Z, Dong Y, Maeda U, Alfille P, Culley DJ, Crosby G, Tanzi RE. The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid beta protein levels. Anesthesiology. 104: 988-94. PMID 16645451 DOI: 10.1097/00000542-200605000-00015  0.414
2006 Liu G, Huang W, Moir RD, Vanderburg CR, Lai B, Peng Z, Tanzi RE, Rogers JT, Huang X. Metal exposure and Alzheimer's pathogenesis. Journal of Structural Biology. 155: 45-51. PMID 16503166 DOI: 10.1016/J.Jsb.2005.12.011  0.441
2006 Norambuena A, Wallrabe H, Cao R, Wang DB, Silva A, Svindrych Z, Periasamy A, Hu S, Tanzi RE, Kim DY, Bloom GS. O2-12-02: A NOVEL LYSOSOME TO MITOCHONDRIA SIGNALING PATHWAY REGULATES MITOCHONDRIAL ACTIVITY AND IS DISRUPTED BY AMYLOID-β OLIGOMERS Alzheimer's & Dementia. 14: P650-P651. DOI: 10.1016/J.Jalz.2018.06.2707  0.725
2006 Pihlajamaki M, Miller SM, DePeau KM, Celone KA, Bertram L, Tanzi RE, Dickerson BC, Albert MS, Blacker D, Sperling RA. O4-01-02: The effect of APOE-4 on fMRI deactivation in older controls, MCI subjects and AD patients Alzheimer's & Dementia. 2: S74-S75. DOI: 10.1016/J.Jalz.2006.05.292  0.31
2006 Pihlajamaki M, Miller SM, DePeau KM, Celone KA, Bertram L, Tanzi RE, Dickerson BC, Albert MS, Blacker D, Sperling RA. IC-P-071: The effect of APOE-4 on fMRI deactivation in older controls, MCI subjects and AD patients Alzheimer's & Dementia. 2: S681-S681. DOI: 10.1016/J.Jalz.2006.05.2276  0.302
2005 Bertram L, Parkinson M, McQueen MB, Mullin K, Hsiao M, Menon R, Moscarillo TJ, Blacker D, Tanzi RE. Further evidence for LBP-1c/CP2/LSF association in Alzheimer's disease families. Journal of Medical Genetics. 42: 857-62. PMID 16272261 DOI: 10.1136/Jmg.2004.024596  0.373
2005 Dickerson BC, Salat DH, Greve DN, Chua EF, Rand-Giovannetti E, Rentz DM, Bertram L, Mullin K, Tanzi RE, Blacker D, Albert MS, Sperling RA. Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD. Neurology. 65: 404-11. PMID 16087905 DOI: 10.1212/01.Wnl.0000171450.97464.49  0.348
2005 Tesco G, Ginestroni A, Hiltunen M, Kim M, Dolios G, Hyman BT, Wang R, Berezovska O, Tanzi RE. APP substitutions V715F and L720P alter PS1 conformation and differentially affect Abeta and AICD generation. Journal of Neurochemistry. 95: 446-56. PMID 16086682 DOI: 10.1111/J.1471-4159.2005.03381.X  0.412
2005 Koh YH, von Arnim CA, Hyman BT, Tanzi RE, Tesco G. BACE is degraded via the lysosomal pathway. The Journal of Biological Chemistry. 280: 32499-504. PMID 16033761 DOI: 10.1074/Jbc.M506199200  0.376
2005 Xie Z, Romano DM, Tanzi RE. Effects of RNAi-mediated silencing of PEN-2, APH-1a, and nicastrin on wild-type vs FAD mutant forms of presenilin 1. Journal of Molecular Neuroscience : Mn. 25: 67-77. PMID 15781968 DOI: 10.1385/Jmn:25:1:067  0.301
2005 Bertram L, Hsiao M, Mullin K, Parkinson M, Menon R, Moscarillo TJ, Blacker D, Tanzi RE. ACAT1 is not associated with Alzheimer's disease in two independent family-based samples. Molecular Psychiatry. 10: 522-4. PMID 15768051 DOI: 10.1038/Sj.Mp.4001646  0.36
2005 Bertram L, Hiltunen M, Parkinson M, Ingelsson M, Lange C, Ramasamy K, Mullin K, Menon R, Sampson AJ, Hsiao MY, Elliott KJ, Velicelebi G, Moscarillo T, Hyman BT, Wagner SL, ... ... Tanzi RE, et al. Family-based association between Alzheimer's disease and variants in UBQLN1. The New England Journal of Medicine. 352: 884-94. PMID 15745979 DOI: 10.1056/Nejmoa042765  0.39
2005 Moir RD, Tseitlin KA, Soscia S, Hyman BT, Irizarry MC, Tanzi RE. Autoantibodies to redox-modified oligomeric Abeta are attenuated in the plasma of Alzheimer's disease patients. The Journal of Biological Chemistry. 280: 17458-63. PMID 15728175 DOI: 10.1074/Jbc.M414176200  0.435
2005 Xie Z, Romano DM, Tanzi RE. RNA interference-mediated silencing of X11alpha and X11beta attenuates amyloid beta-protein levels via differential effects on beta-amyloid precursor protein processing. The Journal of Biological Chemistry. 280: 15413-21. PMID 15699037 DOI: 10.1074/Jbc.M414353200  0.398
2004 Xie Z, Moir RD, Romano DM, Tesco G, Kovacs DM, Tanzi RE. Hypocapnia induces caspase-3 activation and increases Abeta production. Neuro-Degenerative Diseases. 1: 29-37. PMID 16908971 DOI: 10.1159/000076667  0.583
2004 Dedeoglu A, Cormier K, Payton S, Tseitlin KA, Kremsky JN, Lai L, Li X, Moir RD, Tanzi RE, Bush AI, Kowall NW, Rogers JT, Huang X. Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis. Experimental Gerontology. 39: 1641-9. PMID 15582280 DOI: 10.1016/J.Exger.2004.08.016  0.571
2004 Huang X, Atwood CS, Moir RD, Hartshorn MA, Tanzi RE, Bush AI. Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 9: 954-60. PMID 15578276 DOI: 10.1007/S00775-004-0602-8  0.696
2004 Xie Z, Romano DM, Kovacs DM, Tanzi RE. Effects of RNA interference-mediated silencing of gamma-secretase complex components on cell sensitivity to caspase-3 activation. The Journal of Biological Chemistry. 279: 34130-7. PMID 15184387 DOI: 10.1074/Jbc.M401094200  0.552
2004 Huang X, Moir RD, Tanzi RE, Bush AI, Rogers JT. Redox-active metals, oxidative stress, and Alzheimer's disease pathology. Annals of the New York Academy of Sciences. 1012: 153-63. PMID 15105262 DOI: 10.1196/Annals.1306.012  0.577
2004 Bertram L, Parkinson M, Mullin K, Menon R, Blacker D, Tanzi RE. No association between a previously reported OLR1 3' UTR polymorphism and Alzheimer's disease in a large family sample. Journal of Medical Genetics. 41: 286-8. PMID 15060104 DOI: 10.1136/Jmg.2003.016980  0.348
2004 Farris W, Mansourian S, Leissring MA, Eckman EA, Bertram L, Eckman CB, Tanzi RE, Selkoe DJ. Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein. The American Journal of Pathology. 164: 1425-34. PMID 15039230 DOI: 10.1016/S0002-9440(10)63229-4  0.442
2004 Bertram L, Menon R, Mullin K, Parkinson M, Bradley ML, Blacker D, Tanzi RE. PEN2 is not a genetic risk factor for Alzheimer's disease in a large family sample. Neurology. 62: 304-6. PMID 14745076 DOI: 10.1212/01.Wnl.0000103283.65914.0B  0.429
2004 Nagano S, Huang X, Moir RD, Payton SM, Tanzi RE, Bush AI. Peroxidase activity of cyclooxygenase-2 (COX-2) cross-links beta-amyloid (Abeta) and generates Abeta-COX-2 hetero-oligomers that are increased in Alzheimer's disease. The Journal of Biological Chemistry. 279: 14673-8. PMID 14724276 DOI: 10.1074/Jbc.M313003200  0.573
2004 Rogers JT, Payton S, Greig NH, Jensen R, Cuny G, Lahiri DK, Morse LJ, Tanzi RE, Westaway D, Bush A, Gullans S, Sarang S, Huang X. P4-402 Alzheimer's disease drug discovery targeted to the APP MRNA 5′ untranslated region, a validated target Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81959-6  0.496
2004 Hill WD, Perry RT, Wiener H, Harrell L, Gearha DA, Ozcan O, Blacker D, Tanzi RE, McInnis MG, Bassett SSD, Go RCP. P4-114 Protection from AD by the XMNI gamma (G) polymorphism may be mediated by interactions between vascular AB1-42 and methemoglobin Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81672-5  0.311
2004 Goldstein LE, Hartley DM, Moir RD, Blakely EA, Chang PI, Marcus MA, Martin-Rehrmann M, Ko G, Ericsson MH, Huang X, Tanzi RE, Bush AI, Chylack LT. P1-131 (Aβ) in human lens & aqueous humor: further characterization of a novel AD biomarker Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)80454-8  0.542
2004 Moir RD, Tseitlin KA, Soscia S, Hyman BT, Irizarry MC, Tanzi RE. O2-02-08 Levels of autoantibodies to redox-modified abeta are attenuated in the plasma of Alzheimer's disease patients Neurobiology of Aging. 25: S35-S36. DOI: 10.1016/S0197-4580(04)80118-0  0.37
2003 Ritchie CW, Bush AI, Mackinnon A, Macfarlane S, Mastwyk M, MacGregor L, Kiers L, Cherny R, Li QX, Tammer A, Carrington D, Mavros C, Volitakis I, Xilinas M, Ames D, ... ... Tanzi RE, et al. Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial. Archives of Neurology. 60: 1685-91. PMID 14676042 DOI: 10.1001/Archneur.60.12.1685  0.618
2003 Saunders AJ, Tanzi RE. Welcome to the complex disease world. Alpha2-macroglobulin and Alzheimer's disease. Experimental Neurology. 184: 50-3. PMID 14637079 DOI: 10.1016/J.Expneurol.2003.09.004  0.394
2003 Bush AI, Masters CL, Tanzi RE. Copper, beta-amyloid, and Alzheimer's disease: tapping a sensitive connection. Proceedings of the National Academy of Sciences of the United States of America. 100: 11193-4. PMID 14506299 DOI: 10.1073/Pnas.2135061100  0.531
2003 Saunders AJ, Bertram L, Mullin K, Sampson AJ, Latifzai K, Basu S, Jones J, Kinney D, MacKenzie-Ingano L, Yu S, Albert MS, Moscarillo TJ, Go RC, Bassett SS, Daly MJ, ... ... Tanzi RE, et al. Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin. Human Molecular Genetics. 12: 2765-76. PMID 12966032 DOI: 10.1093/Hmg/Ddg310  0.381
2003 Tesco G, Koh YH, Tanzi RE. Caspase activation increases beta-amyloid generation independently of caspase cleavage of the beta-amyloid precursor protein (APP). The Journal of Biological Chemistry. 278: 46074-80. PMID 12960154 DOI: 10.1074/Jbc.M307809200  0.351
2003 Goldstein LE, Muffat JA, Cherny RA, Moir RD, Ericsson MH, Huang X, Mavros C, Coccia JA, Faget KY, Fitch KA, Masters CL, Tanzi RE, Chylack LT, Bush AI. Cytosolic beta-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease. Lancet. 361: 1258-65. PMID 12699953 DOI: 10.1016/S0140-6736(03)12981-9  0.817
2003 Puglielli L, Tanzi RE, Kovacs DM. Alzheimer's disease: the cholesterol connection. Nature Neuroscience. 6: 345-51. PMID 12658281 DOI: 10.1038/Nn0403-345  0.628
2003 Farris W, Mansourian S, Chang Y, Lindsley L, Eckman EA, Frosch MP, Eckman CB, Tanzi RE, Selkoe DJ, Guenette S. Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proceedings of the National Academy of Sciences of the United States of America. 100: 4162-7. PMID 12634421 DOI: 10.1073/Pnas.0230450100  0.414
2003 Blacker D, Bertram L, Saunders AJ, Moscarillo TJ, Albert MS, Wiener H, Perry RT, Collins JS, Harrell LE, Go RC, Mahoney A, Beaty T, Fallin MD, Avramopoulos D, Chase GA, ... ... Tanzi RE, et al. Results of a high-resolution genome screen of 437 Alzheimer's disease families. Human Molecular Genetics. 12: 23-32. PMID 12490529 DOI: 10.1093/Hmg/Ddg007  0.362
2002 Guénette SY, Chang Y, Hyman BT, Tanzi RE, Rebeck GW. Low-density lipoprotein receptor-related protein levels and endocytic function are reduced by overexpression of the FE65 adaptor protein, FE65L1. Journal of Neurochemistry. 82: 755-62. PMID 12358780 DOI: 10.1046/J.1471-4159.2002.01009.X  0.35
2002 Rogers JT, Randall JD, Eder PS, Huang X, Bush AI, Tanzi RE, Venti A, Payton SM, Giordano T, Nagano S, Cahill CM, Moir R, Lahiri DK, Greig N, Sarang SS, et al. Alzheimer's disease drug discovery targeted to the APP mRNA 5'untranslated region. Journal of Molecular Neuroscience : Mn. 19: 77-82. PMID 12212798 DOI: 10.1007/S12031-002-0014-6  0.52
2002 Rogers JT, Randall JD, Cahill CM, Eder PS, Huang X, Gunshin H, Leiter L, McPhee J, Sarang SS, Utsuki T, Greig NH, Lahiri DK, Tanzi RE, Bush AI, Giordano T, et al. An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript. The Journal of Biological Chemistry. 277: 45518-28. PMID 12198135 DOI: 10.1074/Jbc.M207435200  0.488
2002 Opazo C, Huang X, Cherny RA, Moir RD, Roher AE, White AR, Cappai R, Masters CL, Tanzi RE, Inestrosa NC, Bush AI. Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2). The Journal of Biological Chemistry. 277: 40302-8. PMID 12192006 DOI: 10.1074/Jbc.M206428200  0.583
2002 Bush AI, Tanzi RE. The galvanization of beta-amyloid in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 99: 7317-9. PMID 12032279 DOI: 10.1073/Pnas.122249699  0.452
2002 Killiany RJ, Hyman BT, Gomez-Isla T, Moss MB, Kikinis R, Jolesz F, Tanzi R, Jones K, Albert MS. MRI measures of entorhinal cortex vs hippocampus in preclinical AD. Neurology. 58: 1188-96. PMID 11971085 DOI: 10.1212/Wnl.58.8.1188  0.312
2001 Puglielli L, Konopka G, Pack-Chung E, Ingano LA, Berezovska O, Hyman BT, Chang TY, Tanzi RE, Kovacs DM. Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide. Nature Cell Biology. 3: 905-12. PMID 11584272 DOI: 10.1038/Ncb1001-905  0.603
2001 Albert MS, Moss MB, Tanzi R, Jones K. Preclinical prediction of AD using neuropsychological tests. Journal of the International Neuropsychological Society : Jins. 7: 631-9. PMID 11459114 DOI: 10.1017/S1355617701755105  0.339
2001 Cherny RA, Atwood CS, Xilinas ME, Gray DN, Jones WD, McLean CA, Barnham KJ, Volitakis I, Fraser FW, Kim Y, Huang X, Goldstein LE, Moir RD, Lim JT, Beyreuther K, ... ... Tanzi RE, et al. Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron. 30: 665-76. PMID 11430801 DOI: 10.1016/S0896-6273(01)00317-8  0.727
2001 Rebeck GW, Moir RD, Mui S, Strickland DK, Tanzi RE, Hyman BT. Association of membrane-bound amyloid precursor protein APP with the apolipoprotein E receptor LRP. Brain Research. Molecular Brain Research. 87: 238-45. PMID 11245926 DOI: 10.1016/S0169-328X(01)00006-7  0.338
2001 Bertram L, Guénette S, Jones J, Keeney D, Mullin K, Crystal A, Basu S, Yhu S, Deng A, Rebeck GW, Hyman BT, Go R, McInnis M, Blacker D, Tanzi R. No evidence for genetic association or linkage of the cathepsin D (CTSD) exon 2 polymorphism and Alzheimer disease. Annals of Neurology. 49: 114-6. PMID 11198280 DOI: 10.1002/1531-8249(200101)49:1<114::Aid-Ana18>3.0.Co;2-M  0.39
2000 Cuajungco MP, Fagét KY, Huang X, Tanzi RE, Bush AI. Metal chelation as a potential therapy for Alzheimer's disease. Annals of the New York Academy of Sciences. 920: 292-304. PMID 11193167 DOI: 10.1111/J.1749-6632.2000.Tb06938.X  0.452
2000 Ingano LA, Lentini KM, Kovacs I, Tanzi RE, Kovacs DM. Cytoplasmic presenilin aggregates in proteasome inhibitor-treated cells. Annals of the New York Academy of Sciences. 920: 259-60. PMID 11193161 DOI: 10.1111/J.1749-6632.2000.Tb06933.X  0.536
2000 Bertram L, Blacker D, Mullin K, Keeney D, Jones J, Basu S, Yhu S, McInnis MG, Go RC, Vekrellis K, Selkoe DJ, Saunders AJ, Tanzi RE. Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. Science (New York, N.Y.). 290: 2302-3. PMID 11125142 DOI: 10.1126/Science.290.5500.2302  0.416
2000 Collins JS, Perry RT, Watson B, Harrell LE, Acton RT, Blacker D, Albert MS, Tanzi RE, Bassett SS, McInnis MG, Campbell RD, Go RC. Association of a haplotype for tumor necrosis factor in siblings with late-onset Alzheimer disease: the NIMH Alzheimer Disease Genetics Initiative. American Journal of Medical Genetics. 96: 823-30. PMID 11121190 DOI: 10.1002/1096-8628(20001204)96:6<823::Aid-Ajmg26>3.0.Co;2-I  0.389
2000 Guénette SY, Bertram L, Crystal A, Bakondi B, Hyman BT, Rebeck GW, Tanzi RE, Blacker D. Evidence against association of the FE65 gene (APBB1) intron 13 polymorphism in Alzheimer's patients. Neuroscience Letters. 296: 17-20. PMID 11099823 DOI: 10.1016/S0304-3940(00)01607-4  0.358
2000 Buxbaum JD, Lilliehook C, Chan JY, Go RC, Bassett SS, Tanzi RE, Wasco W, Blacker D. Genomic structure, expression pattern, and chromosomal localization of the human calsenilin gene: no association between an exonic polymorphism and Alzheimer's disease. Neuroscience Letters. 294: 135-8. PMID 11072133 DOI: 10.1016/S0304-3940(00)01553-6  0.691
2000 Yoo AS, Cheng I, Chung S, Grenfell TZ, Lee H, Pack-Chung E, Handler M, Shen J, Xia W, Tesco G, Saunders AJ, Ding K, Frosch MP, Tanzi RE, Kim TW. Presenilin-mediated modulation of capacitative calcium entry. Neuron. 27: 561-72. PMID 11055438 DOI: 10.1016/S0896-6273(00)00066-0  0.387
2000 Cherny RA, Barnham KJ, Lynch T, Volitakis I, Li QX, McLean CA, Multhaup G, Beyreuther K, Tanzi RE, Masters CL, Bush AI. Chelation and intercalation: complementary properties in a compound for the treatment of Alzheimer's disease. Journal of Structural Biology. 130: 209-16. PMID 10940226 DOI: 10.1006/Jsbi.2000.4285  0.63
2000 Atwood CS, Scarpa RC, Huang X, Moir RD, Jones WD, Fairlie DP, Tanzi RE, Bush AI. Characterization of copper interactions with alzheimer amyloid beta peptides: identification of an attomolar-affinity copper binding site on amyloid beta1-42. Journal of Neurochemistry. 75: 1219-33. PMID 10936205 DOI: 10.1046/J.1471-4159.2000.0751219.X  0.659
2000 Atwood CS, Huang X, Khatri A, Scarpa RC, Kim YS, Moir RD, Tanzi RE, Roher AE, Bush AI. Copper catalyzed oxidation of Alzheimer Abeta. Cellular and Molecular Biology (Noisy-Le-Grand, France). 46: 777-83. PMID 10875439  0.648
2000 Goldstein LE, Leopold MC, Huang X, Atwood CS, Saunders AJ, Hartshorn M, Lim JT, Faget KY, Muffat JA, Scarpa RC, Chylack LT, Bowden EF, Tanzi RE, Bush AI. 3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote alpha-crystallin cross-linking by metal ion reduction. Biochemistry. 39: 7266-75. PMID 10852726 DOI: 10.1021/Bi992997S  0.762
2000 Sawamura N, Morishima-Kawashima M, Waki H, Kobayashi K, Kuramochi T, Frosch MP, Ding K, Ito M, Kim TW, Tanzi RE, Oyama F, Tabira T, Ando S, Ihara Y. Mutant presenilin 2 transgenic mice. A large increase in the levels of Abeta 42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin. The Journal of Biological Chemistry. 275: 27901-8. PMID 10846187 DOI: 10.1074/Jbc.M004308200  0.365
2000 Huang X, Cuajungco MP, Atwood CS, Moir RD, Tanzi RE, Bush AI. Alzheimer's disease, beta-amyloid protein and zinc. The Journal of Nutrition. 130: 1488S-92S. PMID 10801964 DOI: 10.1093/Jn/130.5.1488S  0.71
2000 Killiany RJ, Gomez-Isla T, Moss M, Kikinis R, Sandor T, Jolesz F, Tanzi R, Jones K, Hyman BT, Albert MS. Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease. Annals of Neurology. 47: 430-9. PMID 10762153 DOI: 10.1002/1531-8249(200004)47:4<430::Aid-Ana5>3.0.Co;2-I  0.352
2000 Ulery PG, Beers J, Mikhailenko I, Tanzi RE, Rebeck GW, Hyman BT, Strickland DK. Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease. The Journal of Biological Chemistry. 275: 7410-5. PMID 10702315 DOI: 10.1074/Jbc.275.10.7410  0.417
2000 Abbenante G, Kovacs DM, Leung DL, Craik DJ, Tanzi RE, Fairlie DP. Inhibitors of beta-amyloid formation based on the beta-secretase cleavage site. Biochemical and Biophysical Research Communications. 268: 133-5. PMID 10652226 DOI: 10.1006/Bbrc.2000.2098  0.554
2000 Moir RD, Saunders AJ, Craig AS, Romano DM, Ashley HI, Tanzi RE. Abnormal conditions in AD brain may modulate LRP-mediated catabolism of Aβand APP Neurobiology of Aging. 21: 259. DOI: 10.1016/S0197-4580(00)83120-6  0.379
2000 Huang X, Moir RD, Atwood CS, Goldstein LE, Tanzi RE, Bush AI. Enhanced redox interaction of copper-Aβ by homocysteine Neurobiology of Aging. 21: 62. DOI: 10.1016/S0197-4580(00)82500-2  0.646
2000 Bertram L, Blacker D, Jones J, Keeney D, MacKenzi L, Mullin K, Saunders AJ, Tanzi RE. Candidate genes showing no evidence of association with Alzheimer disease — Results of the Nimh-Alzheimer disease genetics initiative Neurobiology of Aging. 21: 129. DOI: 10.1016/S0197-4580(00)82379-9  0.403
2000 Cheng I, Yoo AS, Pack-Chung E, Park S, Saunders AJ, Tanzi RE, Kim T. Inhibition of capacitative calcium entry pathway potentiates presenilin-associated ‘-secretase activities of the amyloid β-precursor protein and Notch Neurobiology of Aging. 21: 118. DOI: 10.1016/S0197-4580(00)82331-3  0.327
2000 Atwood CS, Moir RD, Jones WD, Huang X, Perry G, Tanzi RE, Roher AE, Bush AI. Human amyloid-derived aßcontains tyrosine cross-linked oligomers Neurobiology of Aging. 21: 199. DOI: 10.1016/S0197-4580(00)82237-X  0.655
2000 Kovacs DM, Kovacs I, Lentini KM, Ingano LAM, Puglielli L, Tanzi RE. Effect of familial Alzheimer's disease mutations on the formation of presenilin aggregates in proteasome inhibitor treated cells Neurobiology of Aging. 21: 198. DOI: 10.1016/S0197-4580(00)82234-4  0.391
2000 Pack-Chung E, Cheng I, Wolfe MS, Yoo AS, Felsenstein KM, Tanzi RE, Kim T. Effects of presenilin mutations on γ-secretase cleavage and turnover of the amyloid β-protein precursor C-terminal fragment Neurobiology of Aging. 21: 186. DOI: 10.1016/S0197-4580(00)82179-X  0.339
1999 Cuajungco MP, Lees GJ, Kydd RR, Tanzi RE, Bush AI. Zinc and Alzheimer's Disease: An Update. Nutritional Neuroscience. 2: 191-208. PMID 27415572 DOI: 10.1080/1028415X.1999.11747277  0.452
1999 Huang X, Cuajungco MP, Atwood CS, Hartshorn MA, Tyndall JD, Hanson GR, Stokes KC, Leopold M, Multhaup G, Goldstein LE, Scarpa RC, Saunders AJ, Lim J, Moir RD, Glabe C, ... ... Tanzi RE, et al. Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction. The Journal of Biological Chemistry. 274: 37111-6. PMID 10601271 DOI: 10.1074/Jbc.274.52.37111  0.717
1999 Kovacs DM, Mancini R, Henderson J, Na SJ, Schmidt SD, Kim TW, Tanzi RE. Staurosporine-induced activation of caspase-3 is potentiated by presenilin 1 familial Alzheimer's disease mutations in human neuroglioma cells. Journal of Neurochemistry. 73: 2278-85. PMID 10582585 DOI: 10.1046/J.1471-4159.1999.0732278.X  0.516
1999 Cherny RA, Legg JT, McLean CA, Fairlie DP, Huang X, Atwood CS, Beyreuther K, Tanzi RE, Masters CL, Bush AI. Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion. The Journal of Biological Chemistry. 274: 23223-8. PMID 10438495 DOI: 10.1074/Jbc.274.33.23223  0.725
1999 Moir RD, Atwood CS, Huang X, Tanzi RE, Bush AI. Mounting evidence for the involvement of zinc and copper in Alzheimer's disease. European Journal of Clinical Investigation. 29: 569-70. PMID 10411660 DOI: 10.1046/j.1365-2362.1999.00472.x  0.648
1999 Huang X, Atwood CS, Hartshorn MA, Multhaup G, Goldstein LE, Scarpa RC, Cuajungco MP, Gray DN, Lim J, Moir RD, Tanzi RE, Bush AI. The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction. Biochemistry. 38: 7609-16. PMID 10386999 DOI: 10.1021/Bi990438F  0.65
1999 Moir RD, Atwood CS, Romano DM, Laurans MH, Huang X, Bush AI, Smith JD, Tanzi RE. Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A beta using physiological concentrations. Biochemistry. 38: 4595-603. PMID 10194381 DOI: 10.1021/Bi982437D  0.666
1999 Atwood CS, Huang X, Moir RD, Tanzi RE, Bush AI. Role of free radicals and metal ions in the pathogenesis of Alzheimer's disease. Metal Ions in Biological Systems. 36: 309-64. PMID 10093929 DOI: 10.1201/9780203747605-10  0.646
1999 Huang X, Atwood CS, Hartshorn MA, Multhaup G, Goldstein LE, Scarpa RC, Cuajungco MP, Gray DN, Lim J, Moir RD, Tanzi RE, Bush AI. The Aβ peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction Biochemistry. 38: X-7616.  0.549
1998 Price DL, Tanzi RE, Borchelt DR, Sisodia SS. Alzheimer's disease: genetic studies and transgenic models. Annual Review of Genetics. 32: 461-93. PMID 9928488 DOI: 10.1146/Annurev.Genet.32.1.461  0.434
1998 Kovacs DM, Tanzi RE. Monogenic determinants of familial Alzheimer's disease: presenilin-1 mutations. Cellular and Molecular Life Sciences : Cmls. 54: 902-9. PMID 9791532 DOI: 10.1007/S000180050219  0.516
1998 Bush AI, Tanzi RE. Alzheimer disease-related abnormalities of amyloid beta precursor protein isoforms in the platelet: the brain's delegate in the periphery? Archives of Neurology. 55: 1179-80. PMID 9740110 DOI: 10.1001/Archneur.55.9.1179  0.452
1998 McNamara MJ, Ruff CT, Wasco W, Tanzi RE, Thinakaran G, Hyman BT. Immunohistochemical and in situ analysis of amyloid precursor-like protein-1 and amyloid precursor-like protein-2 expression in Alzheimer disease and aged control brains. Brain Research. 804: 45-51. PMID 9729270 DOI: 10.1016/S0006-8993(98)00653-2  0.713
1998 Etcheberrigaray R, Hirashima N, Nee L, Prince J, Govoni S, Racchi M, Tanzi RE, Alkon DL. Calcium responses in fibroblasts from asymptomatic members of Alzheimer's disease families. Neurobiology of Disease. 5: 37-45. PMID 9702786 DOI: 10.1006/Nbdi.1998.0176  0.393
1998 Blacker D, Wilcox MA, Laird NM, Rodes L, Horvath SM, Go RC, Perry R, Watson B, Bassett SS, McInnis MG, Albert MS, Hyman BT, Tanzi RE. Alpha-2 macroglobulin is genetically associated with Alzheimer disease. Nature Genetics. 19: 357-60. PMID 9697696 DOI: 10.1038/1243  0.427
1998 Xia MQ, Berezovska O, Kim TW, Xia WM, Liao A, Tanzi RE, Selkoe D, Hyman BT. Lack of specific association of presenilin 1 (PS-1) protein with plaques and tangles in Alzheimer's disease. Journal of the Neurological Sciences. 158: 15-23. PMID 9667772 DOI: 10.1016/S0022-510X(98)00106-3  0.426
1998 Atwood CS, Moir RD, Huang X, Scarpa RC, Bacarra NM, Romano DM, Hartshorn MA, Tanzi RE, Bush AI. Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis. The Journal of Biological Chemistry. 273: 12817-26. PMID 9582309 DOI: 10.1074/Jbc.273.21.12817  0.668
1998 Hock C, Golombowski S, Müller-Spahn F, Naser W, Beyreuther K, Mönning U, Schenk D, Vigo-Pelfrey C, Bush AM, Moir R, Tanzi RE, Growdon JH, Nitsch RM. Cerebrospinal fluid levels of amyloid precursor protein and amyloid beta-peptide in Alzheimer's disease and major depression - inverse correlation with dementia severity. European Neurology. 39: 111-8. PMID 9520072 DOI: 10.1159/000007917  0.434
1998 Blacker D, Tanzi RE. The genetics of Alzheimer disease: current status and future prospects. Archives of Neurology. 55: 294-6. PMID 9520001 DOI: 10.1001/Archneur.55.3.294  0.403
1998 Moir RD, Lynch T, Bush AI, Whyte S, Henry A, Portbury S, Multhaup G, Small DH, Tanzi RE, Beyreuther K, Masters CL. Relative increase in Alzheimer's disease of soluble forms of cerebral Abeta amyloid protein precursor containing the Kunitz protease inhibitory domain. The Journal of Biological Chemistry. 273: 5013-9. PMID 9478949 DOI: 10.1074/Jbc.273.9.5013  0.599
1997 Huang X, Atwood CS, Moir RD, Hartshorn MA, Vonsattel JP, Tanzi RE, Bush AI. Zinc-induced Alzheimer's Abeta1-40 aggregation is mediated by conformational factors. The Journal of Biological Chemistry. 272: 26464-70. PMID 9334223 DOI: 10.1074/Jbc.272.42.26464  0.689
1997 Kim TW, Pettingell WH, Jung YK, Kovacs DM, Tanzi RE. Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. Science (New York, N.Y.). 277: 373-6. PMID 9219695 DOI: 10.1126/Science.277.5324.373  0.584
1997 Gómez-Isla T, Wasco W, Pettingell WP, Gurubhagavatula S, Schmidt SD, Jondro PD, McNamara M, Rodes LA, DiBlasi T, Growdon WB, Seubert P, Schenk D, Growdon JH, Hyman BT, Tanzi RE. A novel presenilin-1 mutation: increased beta-amyloid and neurofibrillary changes. Annals of Neurology. 41: 809-13. PMID 9189043 DOI: 10.1002/Ana.410410618  0.645
1997 Seeger M, Nordstedt C, Petanceska S, Kovacs DM, Gouras GK, Hahne S, Fraser P, Levesque L, Czernik AJ, George-Hyslop PS, Sisodia SS, Thinakaran G, Tanzi RE, Greengard P, Gandy S. Evidence for phosphorylation and oligomeric assembly of presenilin 1. Proceedings of the National Academy of Sciences of the United States of America. 94: 5090-4. PMID 9144195 DOI: 10.1073/Pnas.94.10.5090  0.544
1997 Kim TW, Pettingell WH, Hallmark OG, Moir RD, Wasco W, Tanzi RE. Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells. The Journal of Biological Chemistry. 272: 11006-10. PMID 9110991 DOI: 10.1074/Jbc.272.17.11006  0.626
1997 Suzuki T, Ando K, Isohara T, Oishi M, Lim GS, Satoh Y, Wasco W, Tanzi RE, Nairn AC, Greengard P, Gandy SE, Kirino Y. Phosphorylation of Alzheimer beta-amyloid precursor-like proteins. Biochemistry. 36: 4643-9. PMID 9109675 DOI: 10.1021/Bi962618K  0.656
1997 Blacker D, Haines JL, Rodes L, Terwedow H, Go RC, Harrell LE, Perry RT, Bassett SS, Chase G, Meyers D, Albert MS, Tanzi R. ApoE-4 and age at onset of Alzheimer's disease: the NIMH genetics initiative. Neurology. 48: 139-47. PMID 9008509 DOI: 10.1212/Wnl.48.1.139  0.375
1997 Berezovska O, Xia MQ, Page K, Wasco W, Tanzi RE, Hyman BT. Developmental regulation of presenilin mRNA expression parallels notch expression. Journal of Neuropathology and Experimental Neurology. 56: 40-4. PMID 8990127 DOI: 10.1097/00005072-199701000-00004  0.646
1996 Tanzi RE, Kovacs DM, Kim TW, Moir RD, Guenette SY, Wasco W. The gene defects responsible for familial Alzheimer's disease. Neurobiology of Disease. 3: 159-68. PMID 8980016 DOI: 10.1006/Nbdi.1996.0016  0.701
1996 Page K, Hollister R, Tanzi RE, Hyman BT. In situ hybridization analysis of presenilin 1 mRNA in Alzheimer disease and in lesioned rat brain. Proceedings of the National Academy of Sciences of the United States of America. 93: 14020-4. PMID 8943053 DOI: 10.1073/Pnas.93.24.14020  0.407
1996 Cook DG, Sung JC, Golde TE, Felsenstein KM, Wojczyk BS, Tanzi RE, Trojanowski JQ, Lee VM, Doms RW. Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites. Proceedings of the National Academy of Sciences of the United States of America. 93: 9223-8. PMID 8799182 DOI: 10.1073/Pnas.93.17.9223  0.334
1996 Irizarry MC, Kim TW, McNamara M, Tanzi RE, George JM, Clayton DF, Hyman BT. Characterization of the precursor protein of the non-A beta component of senile plaques (NACP) in the human central nervous system. Journal of Neuropathology and Experimental Neurology. 55: 889-95. PMID 8759778 DOI: 10.1097/00005072-199608000-00004  0.429
1996 Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird TD, Hardy J, Hutton M, Kukull W, Larson E, Levy-Lahad E, Viitanen M, Peskind E, Poorkaj P, ... ... Tanzi R, et al. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nature Medicine. 2: 864-70. PMID 8705854 DOI: 10.1038/Nm0896-864  0.675
1996 Kovacs DM, Fausett HJ, Page KJ, Kim TW, Moir RD, Merriam DE, Hollister RD, Hallmark OG, Mancini R, Felsenstein KM, Hyman BT, Tanzi RE, Wasco W. Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells. Nature Medicine. 2: 224-9. PMID 8574969 DOI: 10.1038/Nm0296-224  0.741
1996 Kim T, Hallmark O, Pettingell W, Wasco W, Tanzi R. 624 Proteolytic processing of wild-type and mutant forms of presenilin 2 Neurobiology of Aging. 17: S155. DOI: 10.1016/S0197-4580(96)80626-9  0.626
1996 Tanzi R, Kovacs D, Kim T, Moir R, Reebeck G, Strickland D, Hyman B, Wasco W. 602 The genes responsible for familial Alzheimer's disease: Toward a common etiological pathway Neurobiology of Aging. 17: S150. DOI: 10.1016/S0197-4580(96)80604-X  0.74
1996 Kovacs DM, Wasco W, Tanzi RE. 546 Detection of wild-type and mutant forms of presenilin 1 in mammalian cell membranes Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80548-3  0.626
1996 Wasco W, Kovacs D, Kim T, Tanzi R. 545 Characterization and analysis of presenilin 2 in mammalian cells: Normal role and effect of FAD-associated mutations Neurobiology of Aging. 17: S136. DOI: 10.1016/S0197-4580(96)80547-1  0.626
1996 Atwood C, Moir R, Huang X, Bacarra N, Margo L, Glabe C, Tanzi R, Bush A. 527 Modulation of Aβ and mutant aggregation in vitro by zinc and pH Neurobiology of Aging. 17: S131. DOI: 10.1016/S0197-4580(96)80529-X  0.644
1996 Bush A, Atwood C, Huang X, Moir R, Glabe C, Tanzi R. Abnormal homeostasis of pH and Zinc: The prelude for cerebral Aβ amyloid formation? European Neuropsychopharmacology. 6: 20. DOI: 10.1016/S0197-4580(96)80524-0  0.668
1996 Andoo K, Satoh Y, Isohara T, Oishi M, Iijima K, Lim G, Wasco W, Tanzi R, Naim A, Kirino Y, Greengard P, Gandyl S, Suzuki T. 389 Phosphorylation of APLP2 in cell cycle-dependent manner Neurobiology of Aging. 17: S97. DOI: 10.1016/S0197-4580(96)80391-5  0.608
1996 Younkin S, Scheuner D, Song X, Eckman C, Citron M, Suzuki N, Bird T, Hardy J, Hutton M, Lannfelt L, Levy-Lahad E, Peskind E, Poorkaj P, Schellenberg G, Tanzi R, et al. 149 The Presenilin 1 and 2 mutations linked to familial Alzheimer's Disease increase the extracellular concentration of amyloid 0 protein (Aβ) ending at Aβ42(43) Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80151-5  0.718
1996 Younkin SG, Song XH, Scheuner D, Eckman C, Prada C, Jensen J, Lannfelt L, Hardy J, Tanzi R, Schellenberg G, Selkoe D, Suzuki N. The effect of amyloid precursor protein and presenilin mutations on amyloid beta protein Biological Psychiatry. 39: 562. DOI: 10.1016/0006-3223(96)84161-8  0.365
1995 Bush AI, Moir RD, Rosenkranz KM, Tanzi RE. Response. Science (New York, N.Y.). 268: 1921-3. PMID 17797535 DOI: 10.1126/science.268.5219.1921  0.374
1995 Kovacs DM, Wasco W, Witherby J, Felsenstein KM, Brunel F, Roeder RG, Tanzi RE. The upstream stimulatory factor functionally interacts with the Alzheimer amyloid beta-protein precursor gene. Human Molecular Genetics. 4: 1527-33. PMID 8541835 DOI: 10.1093/Hmg/4.9.1527  0.757
1995 Locke PA, Conneally PM, Tanzi RE, Gusella JF, Haines JL. Apolipoprotein E4 allele and Alzheimer disease: examination of allelic association and effect on age at onset in both early- and late-onset cases. Genetic Epidemiology. 12: 83-92. PMID 7713402 DOI: 10.1002/Gepi.1370120108  0.519
1995 Webster MT, Groome N, Francis PT, Pearce BR, Sherriff FE, Thinakaran G, Felsenstein KM, Wasco W, Tanzi RE, Bowen DM. A novel protein, amyloid precursor-like protein 2, is present in human brain, cerebrospinal fluid and conditioned media. The Biochemical Journal. 310: 95-9. PMID 7646477 DOI: 10.1042/Bj3100095  0.659
1995 Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Rimmler JB, Locke PA, Conneally PM, Schmader KE, Tanzi RE. Apolipoprotein E, survival in Alzheimer's disease patients, and the competing risks of death and Alzheimer's disease. Neurology. 45: 1323-8. PMID 7617191 DOI: 10.1212/Wnl.45.7.1323  0.381
1995 Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, Tsuda T, Mar L, Foncin JF, Bruni AC, Montesi MP, ... ... Tanzi RE, et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature. 375: 754-60. PMID 7596406 DOI: 10.1038/375754A0  0.705
1995 Kounnas MZ, Moir RD, Rebeck GW, Bush AI, Argraves WS, Tanzi RE, Hyman BT, Strickland DK. LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation. Cell. 82: 331-40. PMID 7543026 DOI: 10.1016/0092-8674(95)90320-8  0.474
1995 Kim TW, Wu K, Xu JL, McAuliffe G, Tanzi RE, Wasco W, Black IB. Selective localization of amyloid precursor-like protein 1 in the cerebral cortex postsynaptic density. Brain Research. Molecular Brain Research. 32: 36-44. PMID 7494461 DOI: 10.1016/0169-328X(95)00328-P  0.687
1994 Bush AI, Pettingell WH, Paradis MD, Tanzi RE. Modulation of A beta adhesiveness and secretase site cleavage by zinc. The Journal of Biological Chemistry. 269: 12152-8. PMID 8163520  0.433
1994 Bush AI, Pettingell WH, Multhaup G, d Paradis M, Vonsattel JP, Gusella JF, Beyreuther K, Masters CL, Tanzi RE. Rapid induction of Alzheimer A beta amyloid formation by zinc. Science (New York, N.Y.). 265: 1464-7. PMID 8073293 DOI: 10.1126/Science.8073293  0.616
1994 Ali G, Wasco W, Cai X, Szabo P, Sheu KF, Cooper AJ, Gaston SM, Gusella JF, Tanzi RE, Blass JP. Isolation, characterization, and mapping of gene encoding dihydrolipoyl succinyltransferase (E2k) of human alpha-ketoglutarate dehydrogenase complex. Somatic Cell and Molecular Genetics. 20: 99-105. PMID 8009371 DOI: 10.1007/Bf02290679  0.7
1994 Bush AI, Pettingell WH, de Paradis M, Tanzi RE, Wasco W. The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily. The Journal of Biological Chemistry. 269: 26618-21. PMID 7929392  0.655
1994 Tanzi RE, Bush AI, Wasco W. Genetic studies of Alzheimer's disease: lessons learned and future imperatives. Neurobiology of Aging. 15: S145-8. PMID 7700440 DOI: 10.1016/0197-4580(94)90193-7  0.679
1993 Tanzi RE, Wenniger JJ, Hyman BT. Cellular specificity and regional distribution of amyloid beta protein precursor alternative transcripts are unaltered in Alzheimer hippocampal formation. Brain Research. Molecular Brain Research. 18: 246-52. PMID 8497186 DOI: 10.1016/0169-328X(93)90196-V  0.443
1993 Wasco W, Brook JD, Tanzi RE. The amyloid precursor-like protein (APLP) gene maps to the long arm of human chromosome 19. Genomics. 15: 237-9. PMID 8432545 DOI: 10.1006/geno.1993.1047  0.592
1993 Pericak-Vance MA, St George-Hyslop PH, Gaskell PC, Growdon J, Crain BJ, Hulette C, Gusella JF, Yamaoka L, Tanzi RE, Roses AD. Linkage analysis in familial Alzheimer disease: description of the Duke and Boston data sets. Genetic Epidemiology. 10: 361-4. PMID 8314027 DOI: 10.1002/Gepi.1370100605  0.502
1993 Tanzi RE, Petrukhin K, Chernov I, Pellequer JL, Wasco W, Ross B, Romano DM, Parano E, Pavone L, Brzustowicz LM. The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene. Nature Genetics. 5: 344-50. PMID 8298641 DOI: 10.1038/Ng1293-344  0.658
1993 Wasco W, Peppercorn J, Tanzi RE. Search for the genes responsible for familial Alzheimer's disease. Annals of the New York Academy of Sciences. 695: 203-8. PMID 8239284 DOI: 10.1111/J.1749-6632.1993.Tb23053.X  0.626
1993 Rogaev EI, Lukiw WJ, Vaula G, Haines JL, Rogaeva EA, Tsuda T, Alexandrova N, Liang Y, Mortilla M, Amaducci L, Bergamini L, Bruni AC, Foncin JF, Macciardi F, Montesi M, ... ... Tanzi R, et al. Analysis of the c-FOS gene on chromosome 14 and the promoter of the amyloid precursor protein gene in familial Alzheimer's disease. Neurology. 43: 2275-9. PMID 8232942 DOI: 10.1212/Wnl.43.11.2275  0.508
1993 Wasco W, Gurubhagavatula S, Paradis MD, Romano DM, Sisodia SS, Hyman BT, Neve RL, Tanzi RE. Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor. Nature Genetics. 5: 95-100. PMID 8220435 DOI: 10.1038/Ng0993-95  0.703
1993 Tanzi R, Gaston S, Bush A, Romano D, Pettingell W, Peppercorn J, Paradis M, Gurubhagavatula S, Jenkins B, Wasco W. Genetic heterogeneity of gene defects responsible for familial Alzheimer disease. Genetica. 91: 255-63. PMID 8125274 DOI: 10.1007/Bf01436002  0.716
1993 Locke PA, MacDonald ME, Srinidhi J, Gilliam TC, Tanzi RE, Conneally PM, Wexler NS, Haines JL, Gusella JF. A genetic linkage map of the chromosome 4 short arm. Somatic Cell and Molecular Genetics. 19: 95-101. PMID 8096345 DOI: 10.1007/Bf01233958  0.447
1993 Hyman BT, Wenniger JJ, Tanzi RE. Nonisotopic in situ hybridization of amyloid beta protein precursor in Alzheimer's disease: expression in neurofibrillary tangle bearing neurons and in the microenvironment surrounding senile plaques. Brain Research. Molecular Brain Research. 18: 253-8. PMID 7684484 DOI: 10.1016/0169-328X(93)90197-W  0.383
1992 Hyman BT, Tanzi RE, Marzloff K, Barbour R, Schenk D. Kunitz protease inhibitor-containing amyloid beta protein precursor immunoreactivity in Alzheimer's disease. Journal of Neuropathology and Experimental Neurology. 51: 76-83. PMID 1740675 DOI: 10.1097/00005072-199201000-00009  0.409
1992 Tanzi RE, Vaula G, Romano DM, Mortilla M, Huang TL, Tupler RG, Wasco W, Hyman BT, Haines JL, Jenkins BJ. Assessment of amyloid beta-protein precursor gene mutations in a large set of familial and sporadic Alzheimer disease cases. American Journal of Human Genetics. 51: 273-82. PMID 1642228  0.592
1992 Tanzi RE, Romano DM, Berger R, Buraczynska MJ, Gaston SM, Kurnit DM, Patterson D, Gusella JF, Stewart GD. Sequence-tagged sites (STSs) for a set of mapped markers on chromosome 21. Genomics. 14: 498-502. PMID 1427866 DOI: 10.1016/S0888-7543(05)80251-4  0.468
1992 Tanzi RE, Watkins PC, Stewart GD, Wexler NS, Gusella JF, Haines JL. A genetic linkage map of human chromosome 21: analysis of recombination as a function of sex and age. American Journal of Human Genetics. 50: 551-8. PMID 1347193  0.382
1992 Haines JL, Trofatter JA, Tanzi RE, Watkins P, Wexler NS, Conneally PM, Gusella JF. Chromosome 21 genetic linkage data set based on the Venezuelan reference pedigree. Cytogenetics and Cell Genetics. 59: 88-9. PMID 1346592 DOI: 10.1159/000133208  0.457
1992 St George-Hyslop P, Haines J, Rogaev E, Mortilla M, Vaula G, Pericak-Vance M, Foncin JF, Montesi M, Bruni A, Sorbi S, Rainero I, Pinessi L, Pollen D, Polinsky R, Nee L, ... ... Tanzi R, et al. Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14. Nature Genetics. 2: 330-4. PMID 1303289 DOI: 10.1038/Ng1292-330  0.535
1992 Wasco W, Bupp K, Magendantz M, Gusella JF, Tanzi RE, Solomon F. Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor. Proceedings of the National Academy of Sciences of the United States of America. 89: 10758-62. PMID 1279693 DOI: 10.1073/Pnas.89.22.10758  0.747
1991 Tanzi RE, George-Hyslop PS, Gusella JF. Molecular genetics of Alzheimer disease amyloid. The Journal of Biological Chemistry. 266: 20579-82. PMID 1939107  0.382
1991 Tanzi RE, Hyman BT. Alzheimer's mutation. Nature. 350: 564. PMID 1901961 DOI: 10.1038/350564A0  0.345
1991 Tanzi RE, Hyman BT. Studies of amyloid beta-protein precursor expression in Alzheimer's disease. Annals of the New York Academy of Sciences. 640: 149-54. PMID 1776733 DOI: 10.1111/J.1749-6632.1991.Tb00207.X  0.433
1990 Tanzi RE, Haines JL, Gusella JF. Detailed genetic linkage map of human chromosome 21: patterns of recombination according to age and sex. Progress in Clinical and Biological Research. 360: 15-26. PMID 2247506  0.382
1990 Palmert MR, Podlisny MB, Golde TE, Cohen ML, Kovacs DM, Tanzi RE, Gusella JF, Whitehouse PJ, Witker DS, Oltersdorf T. Analysis of the beta-amyloid protein precursor of Alzheimer's disease: mRNAs and protein products. Advances in Neurology. 51: 181-4. PMID 2104687  0.568
1989 St George-Hyslop PH, Tanzi RE, Haines JL, Polinsky RJ, Farrer L, Myers RH, Gusella JF. Molecular genetics of familial Alzheimer's disease. European Neurology. 29: 25-7. PMID 2693103 DOI: 10.1159/000116477  0.543
1989 St George-Hyslop PH, Myers RH, Haines JL, Farrer LA, Tanzi RE, Abe K, James MF, Conneally PM, Polinsky RJ, Gusella JF. Familial Alzheimer's disease: progress and problems. Neurobiology of Aging. 10: 417-25. PMID 2682321 DOI: 10.1016/0197-4580(89)90082-1  0.554
1989 St George-Hyslop PH, Haines JL, Polinsky RJ, Tanzi RE, Farrer L, Myers RH, Gusella JF. Molecular genetics of familial Alzheimer's disease. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 16: 465-7. PMID 2680005 DOI: 10.1017/S0317167100029772  0.532
1989 Van Keuren ML, Stewart GD, Bradley CM, Kurnit DM, Neve RL, Watkins PC, Tanzi RE, Gusella JF, Patterson D. Characterization of an unusual and complex chromosome 21 rearrangement using somatic cell genetics and cloned DNA probes. American Journal of Medical Genetics. 33: 369-75. PMID 2529766 DOI: 10.1002/Ajmg.1320330316  0.443
1989 Palmert MR, Podlisny MB, Golde TE, Cohen ML, Kovacs DM, Tanzi RE, Gusella JF, Whitehouse PJ, Witker DS, Oltersdorf T. The beta amyloid protein precursor: mRNAs, membrane-associated forms, and soluble derivatives. Progress in Clinical and Biological Research. 317: 971-84. PMID 2513588  0.568
1989 Tanzi RE, St George-Hyslop PH, Gusella JF. Molecular genetic approaches to Alzheimer's disease. Trends in Neurosciences. 12: 152-8. PMID 2470173 DOI: 10.1016/0166-2236(89)90055-6  0.457
1988 Sacchi N, Cheng SV, Tanzi RE, Gusella JF, Drabkin HA, Patterson D, Haines JH, Papas TS. The ETS genes on chromosome 21 are distal to the breakpoint of the acute myelogenous leukemia translocation (8;21). Genomics. 3: 110-6. PMID 3267212 DOI: 10.1016/0888-7543(88)90140-1  0.457
1988 Graw S, Davidson J, Gusella J, Watkins P, Tanzi R, Neve R, Patterson D. Irradiation-reduced human chromosome 21 hybrids. Somatic Cell and Molecular Genetics. 14: 233-42. PMID 3163426 DOI: 10.1007/Bf01534584  0.457
1988 Patterson D, Gardiner K, Kao FT, Tanzi R, Watkins P, Gusella JF. Mapping of the gene encoding the beta-amyloid precursor protein and its relationship to the Down syndrome region of chromosome 21. Proceedings of the National Academy of Sciences of the United States of America. 85: 8266-70. PMID 2973063 DOI: 10.1073/Pnas.85.21.8266  0.53
1988 Tanzi RE, Haines JL, Watkins PC, Stewart GD, Wallace MR, Hallewell R, Wong C, Wexler NS, Conneally PM, Gusella JF. Genetic linkage map of human chromosome 21. Genomics. 3: 129-36. PMID 2906323 DOI: 10.1016/0888-7543(88)90143-7  0.457
1988 Phelan MC, Morton CC, Stevenson RE, Tanzi RE, Stewart GD, Watkins PC, Gusella JF, Amos JA. Molecular and cytogenetic characterization of a de novo t(5p;21q) in a patient previously diagnosed as monosomy 21. American Journal of Human Genetics. 43: 511-9. PMID 2902789  0.382
1988 Cheng SV, Nadeau JH, Tanzi RE, Watkins PC, Jagadesh J, Taylor BA, Haines JL, Sacchi N, Gusella JF. Comparative mapping of DNA markers from the familial Alzheimer disease and Down syndrome regions of human chromosome 21 to mouse chromosomes 16 and 17. Proceedings of the National Academy of Sciences of the United States of America. 85: 6032-6. PMID 2901095 DOI: 10.1073/Pnas.85.16.6032  0.482
1988 Tanzi RE, McClatchey AI, Lamperti ED, Villa-Komaroff L, Gusella JF, Neve RL. Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease. Nature. 331: 528-30. PMID 2893290 DOI: 10.1038/331528A0  0.587
1988 Palmert MR, Golde TE, Cohen ML, Kovacs DM, Tanzi RE, Gusella JF, Usiak MF, Younkin LH, Younkin SG. Amyloid protein precursor messenger RNAs: differential expression in Alzheimer's disease. Science (New York, N.Y.). 241: 1080-4. PMID 2457949  0.568
1988 PALMERT MR, GOLDE TE, COHEN ML, KOVACS DM, TANZI RE, GUSELLA JF, USIAK MF, YOUNKIN LH, YOUNKIN SG. AMYLOID PROTEIN PRECURSOR mRNA LACKING THE KUNITZ PROTEASE INHIBITOR SEQUENCE INCREASES IN AD NUCLEUS BASALIS AND LOCUS CERULEUS NEURONS Alzheimer Disease & Associated Disorders. 2: 401. DOI: 10.1097/00002093-198802040-00031  0.457
1988 TANZI RE, GUSELLA JF. GENETIC ANALYSIS OF THE ALZHEIMER??S ASSOCIATED AMYLOID BETA PEPTIDE GENE Alzheimer Disease & Associated Disorders. 2: 277. DOI: 10.1097/00002093-198802030-00126  0.457
1988 Tanzi RE, Gusella JF, Watkins PC, Bruns GA, St.-George HP, Van Keuren ML, Patterson D, Pagan S, Kurnit DM, Neve RL. Amyloid β protein gene Alzheimer Disease & Associated Disorders. 2: 135. DOI: 10.1097/00002093-198802020-00013  0.457
1987 Cheng SV, Gross Lugo T, Tanzi RE, Whitney JB, Fournier RE, Gusella JF. Chromosomal localization of the mouse homolog of the Huntington's disease linked G8 (D4S10) marker. Dna (Mary Ann Liebert, Inc.). 6: 401-7. PMID 2890502  0.396
1987 Tanzi RE, Bird ED, Latt SA, Neve RL. The amyloid beta protein gene is not duplicated in brains from patients with Alzheimer's disease. Science (New York, N.Y.). 238: 666-9. PMID 2890207 DOI: 10.1126/Science.2890207  0.42
1987 St George-Hyslop PH, Tanzi RE, Polinsky RJ, Neve RL, Pollen D, Drachman D, Growdon J, Cupples LA, Nee L, Myers RH. Absence of duplication of chromosome 21 genes in familial and sporadic Alzheimer's disease. Science (New York, N.Y.). 238: 664-6. PMID 2890206 DOI: 10.1126/Science.2890206  0.435
1987 Tanzi RE, St George-Hyslop PH, Haines JL, Polinsky RJ, Nee L, Foncin JF, Neve RL, McClatchey AI, Conneally PM, Gusella JF. The genetic defect in familial Alzheimer's disease is not tightly linked to the amyloid beta-protein gene. Nature. 329: 156-7. PMID 2888020 DOI: 10.1038/329156A0  0.573
1987 Watkins PC, Eddy R, Beck AK, Vellucci V, Leverone B, Tanzi RE, Gusella JF, Shows TB. DNA sequence and regional assignment of the human follicle-stimulating hormone beta-subunit gene to the short arm of human chromosome 11. Dna (Mary Ann Liebert, Inc.). 6: 205-12. PMID 2885163  0.382
1987 Watkins PC, Tanzi RE, Cheng SV, Gusella JF. Molecular genetics of human chromosome 21. Journal of Medical Genetics. 24: 257-70. PMID 2884319 DOI: 10.1136/Jmg.24.5.257  0.457
1987 Gilliam TC, Healey ST, MacDonald ME, Stewart GD, Wasmuth JJ, Tanzi RE, Roy JC, Gusella JF. Isolation of polymorphic DNA fragments from human chromosome 4. Nucleic Acids Research. 15: 1445-58. PMID 2881276 DOI: 10.1093/Nar/15.4.1445  0.443
1987 Wexler NS, Young AB, Tanzi RE, Travers H, Starosta-Rubinstein S, Penney JB, Snodgrass SR, Shoulson I, Gomez F, Ramos Arroyo MA. Homozygotes for Huntington's disease. Nature. 326: 194-7. PMID 2881213 DOI: 10.1038/326194A0  0.318
1987 St George-Hyslop PH, Tanzi RE, Polinsky RJ, Haines JL, Nee L, Watkins PC, Myers RH, Feldman RG, Pollen D, Drachman D. The genetic defect causing familial Alzheimer's disease maps on chromosome 21. Science (New York, N.Y.). 235: 885-90. PMID 2880399 DOI: 10.1126/Science.2880399  0.386
1986 Seizinger BR, Tanzi RE, Gilliam TC, Bader JL, Parry DM, Spence MA, Marazita ML, Gibbons K, Hobbs W, Gusella JF. Genetic linkage analysis of neurofibromatosis with DNA markers. Annals of the New York Academy of Sciences. 486: 304-10. PMID 3105395 DOI: 10.1111/J.1749-6632.1986.Tb48083.X  0.424
1986 Youngman S, Sarfarazi M, Quarrell OWJ, Conneally PM, Gibbons K, Harper PS, Shaw DJ, Tanzi RE, Wallace MR, Gusella JF. Studies of a DNA marker (G8) genetically linked to Huntington disease in British families Human Genetics. 73: 333-339. PMID 3017842 DOI: 10.1007/Bf00279096  0.472
1986 Gusella JF, Gilliam TC, Tanzi RE, MacDonald ME, Cheng SV, Wallace M, Haines J, Conneally PM, Wexler NS. Molecular genetics of Huntington's disease. Cold Spring Harbor Symposia On Quantitative Biology. 51: 359-64. PMID 2884064 DOI: 10.1101/Sqb.1986.051.01.043  0.483
1985 Harper PS, Youngman S, Anderson MA, Sarfarazi M, Quarrell O, Tanzi R, Shaw D, Wallace P, Conneally PM, Gusella JF. Genetic linkage between Huntington's disease and the DNA polymorphism G8 in South Wales families Journal of Medical Genetics. 22: 447-450. PMID 3001311 DOI: 10.1136/Jmg.22.6.447  0.466
1985 Stewart GD, Tanzi RE, Gusella JF. RFLPS at the D21S19 locus of human chromosome 21. Nucleic Acids Research. 13: 7168. PMID 2997741 DOI: 10.1093/Nar/13.19.7168  0.457
1985 Gusella JF, Tanzi RE, Bader PI, Phelan MC, Stevenson R, Hayden MR, Hofman KJ, Faryniarz AG, Gibbons K. Deletion of Huntington's disease-linked G8 (D4S10) locus in Wolf-Hirschhorn syndrome. Nature. 318: 75-8. PMID 2997623 DOI: 10.1038/318075A0  0.497
1985 Gusella JF, Tanzi RE, Watkins PC, Gibbons KT, Hobbs WJ, Faryniarz AG, Healey ST, Anderson MA. Genetic linkage map for chromosome 21. Annals of the New York Academy of Sciences. 450: 25-31. PMID 2990310 DOI: 10.1111/J.1749-6632.1985.Tb21480.X  0.431
1985 Kittur S, Antonarakis S, Tanzi R, Meyers D, Chakravarti A, Groner Y, Phillips J, Watkins P, Gusella J, Kazazian H. A linkage map of three anonymous human DNA fragments and SOD-1 on chromosome 21. The Embo Journal. 4: 2257-2260. DOI: 10.1002/J.1460-2075.1985.Tb03923.X  0.451
1983 Gusella JF, Wexler NS, Conneally PM, Naylor SL, Anderson MA, Tanzi RE, Watkins PC, Ottina K, Wallace MR, Sakaguchi AY, Young AB, Shoulson I, Bonilla E, Martin JB. A polymorphic DNA marker genetically linked to Huntington's disease Nature. 306: 234-238. PMID 6316146 DOI: 10.1038/306234A0  0.311
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