Rudolph E. Tanzi, PhD, Harvard University - Publications

Neurology Harvard Medical School, Boston, MA, United States 

337 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Shin Y, Choi SH, Kim E, Bylykbashi E, Kim JA, Chung S, Kim DY, Kamm RD, Tanzi RE. Blood-Brain Barrier Dysfunction in a 3D In Vitro Model of Alzheimer's Disease. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). 6: 1900962. PMID 31637161 DOI: 10.1002/advs.201900962  0.56
2019 Suh J, Romano DM, Nitschke L, Herrick SP, DiMarzio BA, Dzhala V, Bae JS, Oram MK, Zheng Y, Hooli B, Mullin K, Gennarino VA, Wasco W, Schmahmann JD, Albers MW, ... ... Tanzi RE, et al. Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription. Cell. 178: 1159-1175.e17. PMID 31442405 DOI: 10.1016/j.cell.2019.07.043  0.88
2019 Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, ... ... Tanzi RE, et al. Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics. PMID 31417202 DOI: 10.1038/s41588-019-0495-7  0.4
2019 Moir RD, Tanzi RE. Low Evolutionary Selection Pressure in Senescence Does Not Explain the Persistence of Aβ in the Vertebrate Genome. Frontiers in Aging Neuroscience. 11: 70. PMID 30983989 DOI: 10.3389/fnagi.2019.00070  0.68
2019 Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, ... ... Tanzi RE, et al. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics. 51: 414-430. PMID 30820047 DOI: 10.1038/s41588-019-0358-2  0.4
2018 Eimer WA, Vijaya Kumar DK, Navalpur Shanmugam NK, Rodriguez AS, Mitchell T, Washicosky KJ, György B, Breakefield XO, Tanzi RE, Moir RD. Alzheimer's Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection. Neuron. 100: 1527-1532. PMID 30571943 DOI: 10.1016/j.neuron.2018.11.043  0.68
2018 Norambuena A, Wallrabe H, Cao R, Wang DB, Silva A, Svindrych Z, Periasamy A, Hu S, Tanzi RE, Kim DY, Bloom GS. A novel lysosome-to-mitochondria signaling pathway disrupted by amyloid-β oligomers. The Embo Journal. PMID 30348864 DOI: 10.15252/embj.2018100241  0.56
2018 Moir RD, Lathe R, Tanzi RE. The antimicrobial protection hypothesis of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30314800 DOI: 10.1016/j.jalz.2018.06.3040  0.68
2018 Choi SH, Bylykbashi E, Chatila ZK, Lee SW, Pulli B, Clemenson GD, Kim E, Rompala A, Oram MK, Asselin C, Aronson J, Zhang C, Miller SJ, Lesinski A, Chen JW, ... ... Tanzi RE, et al. Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model. Science (New York, N.Y.). 361. PMID 30190379 DOI: 10.1126/science.aan8821  0.56
2018 Chatila ZK, Kim E, Berlé C, Bylykbashi E, Rompala A, Oram MK, Gupta D, Kwak SS, Kim YH, Kim DY, Choi SH, Tanzi RE. BACE1 Regulates Proliferation and Neuronal Differentiation of Newborn Cells in the Adult Hippocampus in Mice. Eneuro. 5. PMID 30079376 DOI: 10.1523/ENEURO.0067-18.2018  0.56
2018 Eimer WA, Vijaya Kumar DK, Navalpur Shanmugam NK, Rodriguez AS, Mitchell T, Washicosky KJ, György B, Breakefield XO, Tanzi RE, Moir RD. Alzheimer's Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection. Neuron. 99: 56-63.e3. PMID 30001512 DOI: 10.1016/j.neuron.2018.06.030  0.68
2018 Park J, Wetzel I, Marriott I, Dréau D, D'Avanzo C, Kim DY, Tanzi RE, Cho H. A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer's disease. Nature Neuroscience. PMID 29950669 DOI: 10.1038/s41593-018-0175-4  0.56
2018 Jorfi M, D'Avanzo C, Tanzi RE, Kim DY, Irimia D. Human Neurospheroid Arrays for In Vitro Studies of Alzheimer's Disease. Scientific Reports. 8: 2450. PMID 29402979 DOI: 10.1038/s41598-018-20436-8  0.56
2017 Raven F, Ward JF, Zoltowska KM, Wan Y, Bylykbashi E, Miller SJ, Shen X, Choi SH, Rynearson KD, Berezovska O, Wagner SL, Tanzi RE, Zhang C. Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1. Ebiomedicine. PMID 28919280 DOI: 10.1016/j.ebiom.2017.08.028  0.32
2017 Minter MR, Hinterleitner R, Meisel M, Zhang C, Leone V, Zhang X, Oyler-Castrillo P, Zhang X, Musch MW, Shen X, Jabri B, Chang EB, Tanzi RE, Sisodia SS. Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer's disease. Scientific Reports. 7: 10411. PMID 28874832 DOI: 10.1038/s41598-017-11047-w  0.36
2017 Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, ... ... Tanzi RE, et al. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nature Genetics. PMID 28714976 DOI: 10.1038/ng.3916  0.6
2017 Wagner SL, Rynearson KD, Duddy SK, Zhang C, Nguyen PD, Becker A, Vo U, Masliah D, Monte L, Klee JB, Echmalian CM, Xia W, Quinti L, Johnson G, Lin JH, ... ... Tanzi RE, et al. Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606. The Journal of Pharmacology and Experimental Therapeutics. PMID 28416568 DOI: 10.1124/jpet.117.240861  0.56
2016 Choi SH, Kim YH, Quinti L, Tanzi RE, Kim DY. 3D culture models of Alzheimer's disease: a road map to a "cure-in-a-dish". Molecular Neurodegeneration. 11: 75. PMID 27938410 DOI: 10.1186/s13024-016-0139-7  0.56
2016 Bhattacharyya R, Fenn RH, Barren C, Tanzi RE, Kovacs DM. Palmitoylated APP Forms Dimers, Cleaved by BACE1. Plos One. 11: e0166400. PMID 27875558 DOI: 10.1371/journal.pone.0166400  0.92
2016 Vijaya Kumar DK, Eimer WA, Tanzi RE, Moir RD. Alzheimer's disease: the potential therapeutic role of the natural antibiotic amyloid-β peptide. Neurodegenerative Disease Management. PMID 27599536 DOI: 10.2217/nmt-2016-0035  0.68
2016 Minter MR, Zhang C, Leone V, Ringus DL, Zhang X, Oyler-Castrillo P, Musch MW, Liao F, Ward JF, Holtzman DM, Chang EB, Tanzi RE, Sisodia SS. Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease. Scientific Reports. 6: 30028. PMID 27443609 DOI: 10.1038/srep30028  0.88
2016 Rynearson KD, Buckle RN, Barnes KD, Herr RJ, Mayhew NJ, Paquette WD, Sakwa SA, Nguyen PD, Johnson G, Tanzi RE, Wagner SL. Design and synthesis of aminothiazole modulators of the gamma-secretase enzyme. Bioorganic & Medicinal Chemistry Letters. PMID 27426299 DOI: 10.1016/j.bmcl.2016.07.011  0.88
2016 Kumar DK, Choi SH, Washicosky KJ, Eimer WA, Tucker S, Ghofrani J, Lefkowitz A, McColl G, Goldstein LE, Tanzi RE, Moir RD. Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer's disease. Science Translational Medicine. 8: 340ra72. PMID 27225182 DOI: 10.1126/scitranslmed.aaf1059  0.88
2016 Alfonso SI, Callender JA, Hooli B, Antal CE, Mullin K, Sherman MA, Lesné SE, Leitges M, Newton AC, Tanzi RE, Malinow R. Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer's disease. Science Signaling. 9: ra47. PMID 27165780 DOI: 10.1126/scisignal.aaf6209  0.88
2016 Bettayeb K, Hooli BV, Parrado AR, Randolph L, Varotsis D, Aryal S, Gresack J, Tanzi RE, Greengard P, Flajolet M. Relevance of the COPI complex for Alzheimer's disease progression in vivo. Proceedings of the National Academy of Sciences of the United States of America. PMID 27114526 DOI: 10.1073/pnas.1604176113  0.92
2015 Choi SH, Kim YH, D'Avanzo C, Aronson J, Tanzi RE, Kim DY. Recapitulating amyloid β and tau pathology in human neural cell culture models: clinical implications. Us Neurology. 11: 102-105. PMID 27019672 DOI: 10.17925/USN.2015.11.02.102  0.56
2015 Natunen T, Takalo M, Kemppainen S, Leskelä S, Marttinen M, Kurkinen KM, Pursiheimo JP, Sarajärvi T, Viswanathan J, Gabbouj S, Solje E, Tahvanainen E, Pirttimäki T, Kurki M, Paananen J, ... ... Tanzi RE, et al. Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models. Neurobiology of Disease. 85: 187-205. PMID 26563932 DOI: 10.1016/j.nbd.2015.11.005  0.92
2015 Alex A, Li A, Zeng X, Tate RE, McKee ML, Capen DE, Zhang Z, Tanzi RE, Zhou C. A Circadian Clock Gene, Cry, Affects Heart Morphogenesis and Function in Drosophila as Revealed by Optical Coherence Microscopy. Plos One. 10: e0137236. PMID 26348211 DOI: 10.1371/journal.pone.0137236  0.88
2015 Hyman BT, Growdon JH, Albers MW, Buckner RL, Chhatwal J, Gomez-Isla MT, Haass C, Hudry E, Jack CR, Johnson KA, Khachaturian ZS, Kim DY, Martin JB, Nitsch RM, Rosen BR, ... ... Tanzi RE, et al. Massachusetts Alzheimer's Disease Research Center: Progress and challenges. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26297855 DOI: 10.1016/j.jalz.2015.06.1887  0.44
2015 D'Avanzo C, Aronson J, Kim YH, Choi SH, Tanzi RE, Kim DY. Alzheimer's in 3D culture: Challenges and perspectives. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 37: 1139-48. PMID 26252541 DOI: 10.1002/bies.201500063  0.92
2015 Gautam V, D'Avanzo C, Berezovska O, Tanzi RE, Kovacs DM. Synaptotagmins interact with APP and promote Aβ generation. Molecular Neurodegeneration. 10: 31. PMID 26202512 DOI: 10.1186/s13024-015-0028-5  0.88
2015 Zhang X, Tian Y, Zhang C, Tian X, Ross AW, Moir RD, Sun H, Tanzi RE, Moore A, Ran C. Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 26199414 DOI: 10.1073/pnas.1505420112  0.44
2015 Tanzi RE. TREM2 and Risk of Alzheimer's Disease--Friend or Foe? The New England Journal of Medicine. 372: 2564-5. PMID 26107057 DOI: 10.1056/NEJMcibr1503954  0.44
2015 Kim YH, Choi SH, D'Avanzo C, Hebisch M, Sliwinski C, Bylykbashi E, Washicosky KJ, Klee JB, Brüstle O, Tanzi RE, Kim DY. A 3D human neural cell culture system for modeling Alzheimer's disease. Nature Protocols. 10: 985-1006. PMID 26068894 DOI: 10.1038/nprot.2015.065  0.92
2015 Wang H, Sang N, Zhang C, Raghupathi R, Tanzi RE, Saunders A. Cathepsin L Mediates the Degradation of Novel APP C-Terminal Fragments. Biochemistry. 54: 2806-16. PMID 25910068 DOI: 10.1021/acs.biochem.5b00329  0.6
2015 D'Avanzo C, Sliwinski C, Wagner SL, Tanzi RE, Kim DY, Kovacs DM. γ-Secretase modulators reduce endogenous amyloid β42 levels in human neural progenitor cells without altering neuronal differentiation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 25903103 DOI: 10.1096/fj.15-271015  0.92
2015 Hooli BV, Lill CM, Mullin K, Qiao D, Lange C, Bertram L, Tanzi RE. PLD3 gene variants and Alzheimer's disease. Nature. 520: E7-8. PMID 25832413 DOI: 10.1038/nature14040  0.88
2015 Suh J, Moncaster JA, Wang L, Hafeez I, Herz J, Tanzi RE, Goldstein LE, Guénette SY. FE65 and FE65L1 amyloid precursor protein-binding protein compound null mice display adult-onset cataract and muscle weakness. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 29: 2628-39. PMID 25757569 DOI: 10.1096/fj.14-261453  0.44
2015 Weissmiller AM, Natera-Naranjo O, Reyna SM, Pearn ML, Zhao X, Nguyen P, Cheng S, Goldstein LS, Tanzi RE, Wagner SL, Mobley WC, Wu C. A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP. Plos One. 10: e0118379. PMID 25710492 DOI: 10.1371/journal.pone.0118379  0.92
2015 Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, ... ... Tanzi RE, et al. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. Jama Neurology. 72: 209-16. PMID 25531812 DOI: 10.1001/jamaneurol.2014.2157  0.44
2014 Choi SH, Kim YH, Hebisch M, Sliwinski C, Lee S, D'Avanzo C, Chen H, Hooli B, Asselin C, Muffat J, Klee JB, Zhang C, Wainger BJ, Peitz M, Kovacs DM, ... ... Tanzi RE, et al. A three-dimensional human neural cell culture model of Alzheimer's disease. Nature. 515: 274-8. PMID 25307057 DOI: 10.1038/nature13800  0.92
2014 Liu Q, Waltz S, Woodruff G, Ouyang J, Israel MA, Herrera C, Sarsoza F, Tanzi RE, Koo EH, Ringman JM, Goldstein LS, Wagner SL, Yuan SH. Effect of potent γ-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers. Jama Neurology. 71: 1481-9. PMID 25285942 DOI: 10.1001/jamaneurol.2014.2482  0.92
2014 Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, ... ... Tanzi RE, et al. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. Jama Neurology. 71: 1394-404. PMID 25199842 DOI: 10.1001/jamaneurol.2014.1491  0.6
2014 Hooli BV, Parrado AR, Mullin K, Yip WK, Liu T, Roehr JT, Qiao D, Jessen F, Peters O, Becker T, Ramirez A, Lange C, Bertram L, Tanzi RE. The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk. Neurology. 83: 1353-8. PMID 25186855 DOI: 10.1212/WNL.0000000000000855  0.88
2014 Xu Z, Dong Y, Wang H, Culley DJ, Marcantonio ER, Crosby G, Tanzi RE, Zhang Y, Xie Z. Peripheral surgical wounding and age-dependent neuroinflammation in mice. Plos One. 9: e96752. PMID 24796537 DOI: 10.1371/journal.pone.0096752  0.6
2014 Veeraraghavalu K, Zhang C, Zhang X, Tanzi RE, Sisodia SS. Age-dependent, non-cell-autonomous deposition of amyloid from synthesis of β-amyloid by cells other than excitatory neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 3668-73. PMID 24599465 DOI: 10.1523/JNEUROSCI.5079-13.2014  0.6
2014 Xu Z, Dong Y, Wang H, Culley DJ, Marcantonio ER, Crosby G, Tanzi RE, Zhang Y, Xie Z. Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice. Scientific Reports. 4: 3766. PMID 24441878 DOI: 10.1038/srep03766  0.6
2014 Wagner SL, Zhang C, Cheng S, Nguyen P, Zhang X, Rynearson KD, Wang R, Li Y, Sisodia SS, Mobley WC, Tanzi RE. Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species. Biochemistry. 53: 702-13. PMID 24401146 DOI: 10.1021/bi401537v  0.92
2014 Hooli BV, Kovacs-Vajna ZM, Mullin K, Blumenthal MA, Mattheisen M, Zhang C, Lange C, Mohapatra G, Bertram L, Tanzi RE. Rare autosomal copy number variations in early-onset familial Alzheimer's disease. Molecular Psychiatry. 19: 676-81. PMID 23752245 DOI: 10.1038/mp.2013.77  0.88
2013 Bertram L, Parrado AR, Tanzi RE. TREM2 and neurodegenerative disease. The New England Journal of Medicine. 369: 1565. PMID 24131185 DOI: 10.1056/NEJMc1306509#SA2  0.92
2013 Suh J, Choi SH, Romano DM, Gannon MA, Lesinski AN, Kim DY, Tanzi RE. ADAM10 missense mutations potentiate β-amyloid accumulation by impairing prodomain chaperone function. Neuron. 80: 385-401. PMID 24055016 DOI: 10.1016/j.neuron.2013.08.035  0.88
2013 Natunen T, Parrado AR, Helisalmi S, Pursiheimo JP, Sarajärvi T, Mäkinen P, Kurkinen KM, Mullin K, Alafuzoff I, Haapasalo A, Bertram L, Soininen H, Tanzi RE, Hiltunen M. Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 37: 217-32. PMID 23970038 DOI: 10.3233/JAD-130104  0.6
2013 Xie Z, McAuliffe S, Swain CA, Ward SA, Crosby CA, Zheng H, Sherman J, Dong Y, Zhang Y, Sunder N, Burke D, Washicosky KJ, Tanzi RE, Marcantonio ER. Cerebrospinal fluid aβ to tau ratio and postoperative cognitive change. Annals of Surgery. 258: 364-9. PMID 23732272 DOI: 10.1097/SLA.0b013e318298b077  0.6
2013 Veeraraghavalu K, Zhang C, Miller S, Hefendehl JK, Rajapaksha TW, Ulrich J, Jucker M, Holtzman DM, Tanzi RE, Vassar R, Sisodia SS. Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models". Science (New York, N.Y.). 340: 924-f. PMID 23704555 DOI: 10.1126/science.1235505  0.92
2013 Li A, Ahsen OO, Liu JJ, Du C, McKee ML, Yang Y, Wasco W, Newton-Cheh CH, O'Donnell CJ, Fujimoto JG, Zhou C, Tanzi RE. Silencing of the Drosophila ortholog of SOX5 in heart leads to cardiac dysfunction as detected by optical coherence tomography. Human Molecular Genetics. 22: 3798-806. PMID 23696452 DOI: 10.1093/hmg/ddt230  0.88
2013 Viswanathan J, Haapasalo A, Kurkinen KM, Natunen T, Mäkinen P, Bertram L, Soininen H, Tanzi RE, Hiltunen M. Ubiquilin-1 modulates γ-secretase-mediated ε-site cleavage in neuronal cells. Biochemistry. 52: 3899-912. PMID 23663107 DOI: 10.1021/bi400138p  0.92
2013 Griciuc A, Serrano-Pozo A, Parrado AR, Lesinski AN, Asselin CN, Mullin K, Hooli B, Choi SH, Hyman BT, Tanzi RE. Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta. Neuron. 78: 631-43. PMID 23623698 DOI: 10.1016/j.neuron.2013.04.014  0.88
2013 Takalo M, Haapasalo A, Natunen T, Viswanathan J, Kurkinen KM, Tanzi RE, Soininen H, Hiltunen M. Targeting ubiquilin-1 in Alzheimer's disease. Expert Opinion On Therapeutic Targets. 17: 795-810. PMID 23600477 DOI: 10.1517/14728222.2013.791284  0.6
2013 Tanzi RE. A brief history of Alzheimer's disease gene discovery. Journal of Alzheimer's Disease : Jad. 33: S5-13. PMID 22986781 DOI: 10.3233/JAD-2012-129044  0.92
2013 Yun SM, Cho SJ, Song JC, Song SY, Jo SA, Jo C, Yoon K, Tanzi RE, Choi EJ, Koh YH. SUMO1 modulates Aβ generation via BACE1 accumulation. Neurobiology of Aging. 34: 650-62. PMID 22975420 DOI: 10.1016/j.neurobiolaging.2012.08.005  0.92
2013 Craddock TJA, Tuszynski JA, Chopra D, Casey N, Goldstein LE, Hameroff SR, Tanzi RE. Correction: The zinc dyshomeostasis hypothesis of Alzheimer's disease (PLos ONE) Plos One. 8. DOI: 10.1371/annotation/e83fbf22-647f-496f-b27d-5aff26898083  0.32
2012 Xie Z, Dong Y, Maeda U, Xia W, Tanzi RE. RNAi-mediated knock-down of Dab and Numb attenuate Aβ levels via γ-secretase mediated APP processing. Translational Neurodegeneration. 1: 8. PMID 23211096 DOI: 10.1186/2047-9158-1-8  0.92
2012 Tanzi RE. The genetics of Alzheimer disease. Cold Spring Harbor Perspectives in Medicine. 2. PMID 23028126 DOI: 10.1101/cshperspect.a006296  0.6
2012 Wagner SL, Tanzi RE, Mobley WC, Galasko D. Potential use of γ-secretase modulators in the treatment of Alzheimer disease. Archives of Neurology. 69: 1255-8. PMID 22801784 DOI: 10.1001/archneurol.2012.540  0.92
2012 González-Pérez P, Lu Y, Chian RJ, Sapp PC, Tanzi RE, Bertram L, McKenna-Yasek D, Gao FB, Brown RH. Association of UBQLN1 mutation with Brown-Vialetto-Van Laere syndrome but not typical ALS. Neurobiology of Disease. 48: 391-8. PMID 22766032 DOI: 10.1016/j.nbd.2012.06.018  0.6
2012 Allen M, Zou F, Chai HS, Younkin CS, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus KG, Palusak R, ... ... Tanzi RE, et al. Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology. 79: 221-8. PMID 22722634 DOI: 10.1212/WNL.0b013e3182605801  0.6
2012 Goldstein LE, Fisher AM, Tagge CA, Zhang XL, Velisek L, Sullivan JA, Upreti C, Kracht JM, Ericsson M, Wojnarowicz MW, Goletiani CJ, Maglakelidze GM, Casey N, Moncaster JA, Minaeva O, ... ... Tanzi RE, et al. Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model. Science Translational Medicine. 4: 134ra60. PMID 22593173 DOI: 10.1126/scitranslmed.3003716  0.68
2012 Hooli BV, Mohapatra G, Mattheisen M, Parrado AR, Roehr JT, Shen Y, Gusella JF, Moir R, Saunders AJ, Lange C, Tanzi RE, Bertram L. Role of common and rare APP DNA sequence variants in Alzheimer disease. Neurology. 78: 1250-7. PMID 22491860 DOI: 10.1212/WNL.0b013e3182515972  0.92
2012 Bertram L, Tanzi RE. The genetics of Alzheimer's disease. Progress in Molecular Biology and Translational Science. 107: 79-100. PMID 22482448 DOI: 10.1016/B978-0-12-385883-2.00008-4  0.44
2012 Craddock TJ, Tuszynski JA, Chopra D, Casey N, Goldstein LE, Hameroff SR, Tanzi RE. The zinc dyshomeostasis hypothesis of Alzheimer's disease. Plos One. 7: e33552. PMID 22457776 DOI: 10.1371/journal.pone.0033552  0.92
2012 Lill CM, Roehr JT, McQueen MB, Kavvoura FK, Bagade S, Schjeide BM, Schjeide LM, Meissner E, Zauft U, Allen NC, Liu T, Schilling M, Anderson KJ, Beecham G, Berg D, ... ... Tanzi RE, et al. Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. Plos Genetics. 8: e1002548. PMID 22438815 DOI: 10.1371/journal.pgen.1002548  0.6
2012 Choi SH, Tanzi RE. iPSCs to the rescue in Alzheimer's research. Cell Stem Cell. 10: 235-6. PMID 22385650 DOI: 10.1016/j.stem.2012.02.011  0.92
2012 Zhang Y, Xu Z, Wang H, Dong Y, Shi HN, Culley DJ, Crosby G, Marcantonio ER, Tanzi RE, Xie Z. Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory. Annals of Neurology. 71: 687-98. PMID 22368036 DOI: 10.1002/ana.23536  0.6
2012 Won S, Lu Q, Bertram L, Tanzi RE, Lange C. On the meta-analysis of genome-wide association studies: a robust and efficient approach to combine population and family-based studies. Human Heredity. 73: 35-46. PMID 22261799 DOI: 10.1159/000331219  0.6
2012 Zhang B, Tian M, Zhen Y, Yue Y, Sherman J, Zheng H, Li S, Tanzi RE, Marcantonio ER, Xie Z. The effects of isoflurane and desflurane on cognitive function in humans. Anesthesia and Analgesia. 114: 410-5. PMID 22075020 DOI: 10.1213/ANE.0b013e31823b2602  0.6
2012 Wu X, Lu Y, Dong Y, Zhang G, Zhang Y, Xu Z, Culley DJ, Crosby G, Marcantonio ER, Tanzi RE, Xie Z. The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-α, IL-6, and IL-1β. Neurobiology of Aging. 33: 1364-78. PMID 21190757 DOI: 10.1016/j.neurobiolaging.2010.11.002  0.6
2012 Lill CM, Tanzi RE, Bertram L. Genetics of Neurodegenerative Diseases Basic Neurochemistry. 719-736. DOI: 10.1016/B978-0-12-374947-5.00041-9  0.6
2011 Zhang Y, Zhen Y, Dong Y, Xu Z, Yue Y, Golde TE, Tanzi RE, Moir RD, Xie Z. Anesthetic propofol attenuates the isoflurane-induced caspase-3 activation and Aβ oligomerization. Plos One. 6: e27019. PMID 22069482 DOI: 10.1371/journal.pone.0027019  0.6
2011 Treusch S, Hamamichi S, Goodman JL, Matlack KE, Chung CY, Baru V, Shulman JM, Parrado A, Bevis BJ, Valastyan JS, Han H, Lindhagen-Persson M, Reiman EM, Evans DA, Bennett DA, ... ... Tanzi RE, et al. Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast. Science (New York, N.Y.). 334: 1241-5. PMID 22033521 DOI: 10.1126/science.1213210  0.6
2011 Culley DJ, Boyd JD, Palanisamy A, Xie Z, Kojima K, Vacanti CA, Tanzi RE, Crosby G. Isoflurane decreases self-renewal capacity of rat cultured neural stem cells. Anesthesiology. 115: 754-63. PMID 21666433 DOI: 10.1097/ALN.0b013e318223b78b  0.6
2011 Li A, Zhou C, Moore J, Zhang P, Tsai TH, Lee HC, Romano DM, McKee ML, Schoenfeld DA, Serra MJ, Raygor K, Cantiello HF, Fujimoto JG, Tanzi RE. Changes in the expression of the Alzheimer’s disease-associated presenilin gene in drosophila heart leads to cardiac dysfunction. Current Alzheimer Research. 8: 313-22. PMID 21524270 DOI: 10.2174/156720511795563746  0.6
2011 Sarajärvi T, Tuusa JT, Haapasalo A, Lackman JJ, Sormunen R, Helisalmi S, Roehr JT, Parrado AR, Mäkinen P, Bertram L, Soininen H, Tanzi RE, Petäjä-Repo UE, Hiltunen M. Cysteine 27 variant of the delta-opioid receptor affects amyloid precursor protein processing through altered endocytic trafficking. Molecular and Cellular Biology. 31: 2326-40. PMID 21464208 DOI: 10.1128/MCB.05015-11  0.6
2011 Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, ... ... Tanzi RE, et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nature Genetics. 43: 436-41. PMID 21460841 DOI: 10.1038/ng.801  0.48
2011 Schjeide BM, Schnack C, Lambert JC, Lill CM, Kirchheiner J, Tumani H, Otto M, Tanzi RE, Lehrach H, Amouyel P, von Arnim CA, Bertram L. The role of clusterin, complement receptor 1, and phosphatidylinositol binding clathrin assembly protein in Alzheimer disease risk and cerebrospinal fluid biomarker levels. Archives of General Psychiatry. 68: 207-13. PMID 21300948 DOI: 10.1001/archgenpsychiatry.2010.196  0.6
2011 Viswanathan J, Haapasalo A, Böttcher C, Miettinen R, Kurkinen KM, Lu A, Thomas A, Maynard CJ, Romano D, Hyman BT, Berezovska O, Bertram L, Soininen H, Dantuma NP, Tanzi RE, et al. Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation. Traffic (Copenhagen, Denmark). 12: 330-48. PMID 21143716 DOI: 10.1111/j.1600-0854.2010.01149.x  0.6
2011 Mannix RC, Zhang J, Park J, Zhang X, Bilal K, Walker K, Tanzi RE, Tesco G, Whalen MJ. Age-dependent effect of apolipoprotein E4 on functional outcome after controlled cortical impact in mice. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 31: 351-61. PMID 20588316 DOI: 10.1038/jcbfm.2010.99  0.6
2011 Zhang C, Tanzi RE. Response to Mancuso et al.: Curcumin and Alzheimer disease: This marriage is not to be performed Journal of Biological Chemistry. 286: le4. DOI: 10.1074/jbc.N110.133520  0.88
2011 Bertram L, Tanzi RE. Genetics of Alzheimer's Disease Neurodegeneration: the Molecular Pathology of Dementia and Movement Disorders: Second Edition. 51-61. DOI: 10.1002/9781444341256.ch9  0.6
2011 Lane RF, Raines SM, Steele JW, Ehrlich ME, Lah JA, Small SA, Tanzi RE, Attie AD, Gandy S. Diabetes-associated SorCS1 regulates Alzheimer's amyloid-β metabolism: Evidence for involvement of SorL1 and the retromer complex (Journal of Neuroscience (2010) (13110-13115)) Journal of Neuroscience. 31.  0.92
2010 Bertram L, Lill CM, Tanzi RE. The genetics of Alzheimer disease: back to the future. Neuron. 68: 270-81. PMID 20955934 DOI: 10.1016/j.neuron.2010.10.013  0.6
2010 Zhang C, Browne A, Divito JR, Stevenson JA, Romano D, Dong Y, Xie Z, Tanzi RE. Amyloid-β production via cleavage of amyloid-β protein precursor is modulated by cell density. Journal of Alzheimer's Disease : Jad. 22: 683-984. PMID 20847415 DOI: 10.3233/JAD-2010-100816  0.92
2010 Lambert JC, Sleegers K, González-Pérez A, Ingelsson M, Beecham GW, Hiltunen M, Combarros O, Bullido MJ, Brouwers N, Bettens K, Berr C, Pasquier F, Richard F, Dekosky ST, Hannequin D, ... ... Tanzi RE, et al. The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study. Journal of Alzheimer's Disease : Jad. 22: 247-55. PMID 20847397 DOI: 10.3233/JAD-2010-100933  0.92
2010 Kounnas MZ, Danks AM, Cheng S, Tyree C, Ackerman E, Zhang X, Ahn K, Nguyen P, Comer D, Mao L, Yu C, Pleynet D, Digregorio PJ, Velicelebi G, Stauderman KA, ... ... Tanzi RE, et al. Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease. Neuron. 67: 769-80. PMID 20826309 DOI: 10.1016/j.neuron.2010.08.018  0.92
2010 Duce JA, Tsatsanis A, Cater MA, James SA, Robb E, Wikhe K, Leong SL, Perez K, Johanssen T, Greenough MA, Cho HH, Galatis D, Moir RD, Masters CL, McLean C, ... Tanzi RE, et al. Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease. Cell. 142: 857-67. PMID 20817278 DOI: 10.1016/j.cell.2010.08.014  0.88
2010 Zhang C, Browne A, Child D, Tanzi RE. Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein. The Journal of Biological Chemistry. 285: 28472-80. PMID 20622013 DOI: 10.1074/jbc.M110.133520  0.92
2010 Moncaster JA, Pineda R, Moir RD, Lu S, Burton MA, Ghosh JG, Ericsson M, Soscia SJ, Mocofanescu A, Folkerth RD, Robb RM, Kuszak JR, Clark JI, Tanzi RE, Hunter DG, et al. Alzheimer's disease amyloid-beta links lens and brain pathology in Down syndrome. Plos One. 5: e10659. PMID 20502642 DOI: 10.1371/journal.pone.0010659  0.92
2010 Suh J, Im DS, Moon GJ, Ryu KS, de Silva R, Choi IS, Lees AJ, Guénette SY, Tanzi RE, Gwag BJ. Hypoxic ischemia and proteasome dysfunction alter tau isoform ratio by inhibiting exon 10 splicing. Journal of Neurochemistry. 114: 160-70. PMID 20374429 DOI: 10.1111/j.1471-4159.2010.06732.x  0.6
2010 Lill CM, Schjeide BM, Roehr JT, Zauft U, Allen NC, Zipp F, McQueen MB, Kavvoura FK, Ioannidis JP, Khoury MJ, Tanzi RE, Bertram L. Correspondence to Sand et Al. "Critical reappraisal of a catechol-o-methyltransferase transversion variant in schizophrenia". Biological Psychiatry. 67: e45-8. PMID 20303423 DOI: 10.1016/j.biopsych.2010.02.003  0.6
2010 Soscia SJ, Kirby JE, Washicosky KJ, Tucker SM, Ingelsson M, Hyman B, Burton MA, Goldstein LE, Duong S, Tanzi RE, Moir RD. The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide. Plos One. 5: e9505. PMID 20209079 DOI: 10.1371/journal.pone.0009505  0.88
2010 Zhang C, Browne A, Kim DY, Tanzi RE. Familial Alzheimer's disease mutations in presenilin 1 do not alter levels of the secreted amyloid-beta protein precursor generated by beta-secretase cleavage. Current Alzheimer Research. 7: 21-6. PMID 20205669 DOI: 10.2174/156720510790274428  0.88
2010 Gianni D, Li A, Tesco G, McKay KM, Moore J, Raygor K, Rota M, Gwathmey JK, Dec GW, Aretz T, Leri A, Semigran MJ, Anversa P, Macgillivray TE, Tanzi RE, et al. Protein aggregates and novel presenilin gene variants in idiopathic dilated cardiomyopathy. Circulation. 121: 1216-26. PMID 20194882 DOI: 10.1161/CIRCULATIONAHA.109.879510  0.92
2010 Faux NG, Ritchie CW, Gunn A, Rembach A, Tsatsanis A, Bedo J, Harrison J, Lannfelt L, Blennow K, Zetterberg H, Ingelsson M, Masters CL, Tanzi RE, Cummings JL, Herd CM, et al. PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses. Journal of Alzheimer's Disease : Jad. 20: 509-16. PMID 20164561 DOI: 10.3233/JAD-2010-1390  0.6
2010 Zhang C, Browne A, Child D, Divito JR, Stevenson JA, Tanzi RE. Loss of function of ATXN1 increases amyloid beta-protein levels by potentiating beta-secretase processing of beta-amyloid precursor protein. The Journal of Biological Chemistry. 285: 8515-26. PMID 20097758 DOI: 10.1074/jbc.M109.079079  0.92
2010 Haapasalo A, Viswanathan J, Bertram L, Soininen H, Tanzi RE, Hiltunen M. Emerging role of Alzheimer's disease-associated ubiquilin-1 in protein aggregation. Biochemical Society Transactions. 38: 150-5. PMID 20074050 DOI: 10.1042/BST0380150  0.6
2010 Bertram L, Tanzi RE. Alzheimer disease: New light on an old CLU. Nature Reviews. Neurology. 6: 11-3. PMID 20057494 DOI: 10.1038/nrneurol.2009.213  0.6
2010 Giedraitis V, Glaser A, Sarajärvi T, Brundin R, Gunnarsson MD, Schjeide BM, Tanzi RE, Helisalmi S, Pirttilä T, Kilander L, Lannfelt L, Soininen H, Bertram L, Ingelsson M, Hiltunen M. CALHM1 P86L polymorphism does not alter amyloid-beta or tau in cerebrospinal fluid. Neuroscience Letters. 469: 265-7. PMID 20005921 DOI: 10.1016/j.neulet.2009.12.011  0.6
2010 Pihlajamäki M, O' Keefe K, Bertram L, Tanzi RE, Dickerson BC, Blacker D, Albert MS, Sperling RA. Evidence of altered posteromedial cortical FMRI activity in subjects at risk for Alzheimer disease. Alzheimer Disease and Associated Disorders. 24: 28-36. PMID 19571734 DOI: 10.1097/WAD.0b013e3181a785c9  0.92
2009 Won S, Bertram L, Becker D, Tanzi RE, Lange C. Maximizing the Power of Genome-Wide Association Studies: A Novel Class of Powerful Family-Based Association Tests. Statistics in Biosciences. 1: 125-143. PMID 22582089 DOI: 10.1007/s12561-009-9016-z  0.6
2009 Bertram L, Tanzi RE. Genome-wide association studies in Alzheimer's disease. Human Molecular Genetics. 18: R137-45. PMID 19808789 DOI: 10.1093/hmg/ddp406  0.6
2009 Kim M, Suh J, Romano D, Truong MH, Mullin K, Hooli B, Norton D, Tesco G, Elliott K, Wagner SL, Moir RD, Becker KD, Tanzi RE. Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity. Human Molecular Genetics. 18: 3987-96. PMID 19608551 DOI: 10.1093/hmg/ddp323  0.88
2009 Fardo DW, Becker KD, Bertram L, Tanzi RE, Lange C. Recovering unused information in genome-wide association studies: the benefit of analyzing SNPs out of Hardy-Weinberg equilibrium. European Journal of Human Genetics : Ejhg. 17: 1676-82. PMID 19491930 DOI: 10.1038/ejhg.2009.85  0.6
2009 Dong Y, Zhang G, Zhang B, Moir RD, Xia W, Marcantonio ER, Culley DJ, Crosby G, Tanzi RE, Xie Z. The common inhalational anesthetic sevoflurane induces apoptosis and increases beta-amyloid protein levels. Archives of Neurology. 66: 620-31. PMID 19433662 DOI: 10.1001/archneurol.2009.48  0.92
2009 Schjeide BM, Hooli B, Parkinson M, Hogan MF, DiVito J, Mullin K, Blacker D, Tanzi RE, Bertram L. GAB2 as an Alzheimer disease susceptibility gene: follow-up of genomewide association results. Archives of Neurology. 66: 250-4. PMID 19204163 DOI: 10.1001/archneurol.2008.552  0.6
2009 Myre MA, Washicosky K, Moir RD, Tesco G, Tanzi RE, Wasco W. Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1. Cellular Signalling. 21: 567-76. PMID 19154786 DOI: 10.1016/j.cellsig.2008.12.008  0.92
2009 Lu A, Hiltunen M, Romano DM, Soininen H, Hyman BT, Bertram L, Tanzi RE. Effects of ubiquilin 1 on the unfolded protein response. Journal of Molecular Neuroscience : Mn. 38: 19-30. PMID 18953672 DOI: 10.1007/s12031-008-9155-6  0.6
2009 Schjeide BM, McQueen MB, Mullin K, DiVito J, Hogan MF, Parkinson M, Hooli B, Lange C, Blacker D, Tanzi RE, Bertram L. Assessment of Alzheimer's disease case-control associations using family-based methods. Neurogenetics. 10: 19-25. PMID 18830724 DOI: 10.1007/s10048-008-0151-3  0.44
2008 Bertram L, Schjeide BM, Hooli B, Mullin K, Hiltunen M, Soininen H, Ingelsson M, Lannfelt L, Blacker D, Tanzi RE. No association between CALHM1 and Alzheimer's disease risk. Cell. 135: 993-4; author reply . PMID 19070563 DOI: 10.1016/j.cell.2008.11.030  0.6
2008 Xie Z, Culley DJ, Dong Y, Zhang G, Zhang B, Moir RD, Frosch MP, Crosby G, Tanzi RE. The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta-protein level in vivo. Annals of Neurology. 64: 618-27. PMID 19006075 DOI: 10.1002/ana.21548  0.88
2008 Bertram L, Lange C, Mullin K, Parkinson M, Hsiao M, Hogan MF, Schjeide BM, Hooli B, Divito J, Ionita I, Jiang H, Laird N, Moscarillo T, Ohlsen KL, Elliott K, ... ... Tanzi RE, et al. Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. American Journal of Human Genetics. 83: 623-32. PMID 18976728 DOI: 10.1016/j.ajhg.2008.10.008  0.6
2008 Schaffer BA, Bertram L, Miller BL, Mullin K, Weintraub S, Johnson N, Bigio EH, Mesulam M, Wiedau-Pazos M, Jackson GR, Cummings JL, Cantor RM, Levey AI, Tanzi RE, Geschwind DH. Association of GSK3B with Alzheimer disease and frontotemporal dementia. Archives of Neurology. 65: 1368-74. PMID 18852354 DOI: 10.1001/archneur.65.10.1368  0.6
2008 Lee IH, Culley DJ, Baxter MG, Xie Z, Tanzi RE, Crosby G. Spatial memory is intact in aged rats after propofol anesthesia. Anesthesia and Analgesia. 107: 1211-5. PMID 18806029 DOI: 10.1213/ane.0b013e31817ee879  0.6
2008 Bertram L, Tanzi RE. Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses. Nature Reviews. Neuroscience. 9: 768-78. PMID 18802446 DOI: 10.1038/nrn2494  0.6
2008 Kavvoura FK, McQueen MB, Khoury MJ, Tanzi RE, Bertram L, Ioannidis JP. Evaluation of the potential excess of statistically significant findings in published genetic association studies: application to Alzheimer's disease. American Journal of Epidemiology. 168: 855-65. PMID 18779388 DOI: 10.1093/aje/kwn206  0.6
2008 Tanzi RE, Bertram L. Alzheimer's disease: The latest suspect. Nature. 454: 706-8. PMID 18685694 DOI: 10.1038/454706a  0.88
2008 Bush AI, Tanzi RE. Therapeutics for Alzheimer's disease based on the metal hypothesis. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 5: 421-32. PMID 18625454 DOI: 10.1016/j.nurt.2008.05.001  0.88
2008 Tanzi RE. Novel therapeutics for Alzheimer's disease. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 5: 377-80. PMID 18625448 DOI: 10.1016/j.nurt.2008.05.012  0.6
2008 Adlard PA, Cherny RA, Finkelstein DI, Gautier E, Robb E, Cortes M, Volitakis I, Liu X, Smith JP, Perez K, Laughton K, Li QX, Charman SA, Nicolazzo JA, Wilkins S, ... ... Tanzi RE, et al. Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta. Neuron. 59: 43-55. PMID 18614028 DOI: 10.1016/j.neuron.2008.06.018  0.88
2008 Allen NC, Bagade S, McQueen MB, Ioannidis JP, Kavvoura FK, Khoury MJ, Tanzi RE, Bertram L. Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nature Genetics. 40: 827-34. PMID 18583979 DOI: 10.1038/ng.171  0.6
2008 Zhang G, Dong Y, Zhang B, Ichinose F, Wu X, Culley DJ, Crosby G, Tanzi RE, Xie Z. Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 4551-60. PMID 18434534 DOI: 10.1523/JNEUROSCI.5694-07.2008  0.92
2008 Zhang B, Dong Y, Zhang G, Moir RD, Xia W, Yue Y, Tian M, Culley DJ, Crosby G, Tanzi RE, Xie Z. The inhalation anesthetic desflurane induces caspase activation and increases amyloid beta-protein levels under hypoxic conditions. The Journal of Biological Chemistry. 283: 11866-75. PMID 18326038 DOI: 10.1074/jbc.M800199200  0.88
2008 Smith EE, Egorova S, Blacker D, Killiany RJ, Muzikansky A, Dickerson BC, Tanzi RE, Albert MS, Greenberg SM, Guttmann CR. Magnetic resonance imaging white matter hyperintensities and brain volume in the prediction of mild cognitive impairment and dementia. Archives of Neurology. 65: 94-100. PMID 18195145 DOI: 10.1001/archneurol.2007.23  0.6
2008 Weiss LA, Shen Y, Korn JM, Arking DE, Miller DT, Fossdal R, Saemundsen E, Stefansson H, Ferreira MA, Green T, Platt OS, Ruderfer DM, Walsh CA, Altshuler D, Chakravarti A, ... Tanzi RE, et al. Association between microdeletion and microduplication at 16p11.2 and autism. The New England Journal of Medicine. 358: 667-75. PMID 18184952 DOI: 10.1056/NEJMoa075974  0.76
2007 Hamshere ML, Holmans PA, Avramopoulos D, Bassett SS, Blacker D, Bertram L, Wiener H, Rochberg N, Tanzi RE, Myers A, Wavrant-De Vrièze F, Go R, Fallin D, Lovestone S, Hardy J, et al. Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease. Human Molecular Genetics. 16: 2703-12. PMID 17725986 DOI: 10.1093/hmg/ddm224  0.6
2007 Zhang C, Khandelwal PJ, Chakraborty R, Cuellar TL, Sarangi S, Patel SA, Cosentino CP, O'Connor M, Lee JC, Tanzi RE, Saunders AJ. An AICD-based functional screen to identify APP metabolism regulators. Molecular Neurodegeneration. 2: 15. PMID 17718916 DOI: 10.1186/1750-1326-2-15  0.88
2007 Li A, Xie Z, Dong Y, McKay KM, McKee ML, Tanzi RE. Isolation and characterization of the Drosophila ubiquilin ortholog dUbqln: in vivo interaction with early-onset Alzheimer disease genes. Human Molecular Genetics. 16: 2626-39. PMID 17704509 DOI: 10.1093/hmg/ddm219  0.88
2007 Huttunen HJ, Guénette SY, Peach C, Greco C, Xia W, Kim DY, Barren C, Tanzi RE, Kovacs DM. HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation. The Journal of Biological Chemistry. 282: 28285-95. PMID 17684015 DOI: 10.1074/jbc.M702951200  0.6
2007 McQueen MB, Bertram L, Lange C, Becker KD, Albert MS, Tanzi RE, Blacker D. Exploring candidate gene associations with neuropsychological performance. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 144: 987-91. PMID 17579348 DOI: 10.1002/ajmg.b.30500  0.6
2007 Tesco G, Koh YH, Kang EL, Cameron AN, Das S, Sena-Esteves M, Hiltunen M, Yang SH, Zhong Z, Shen Y, Simpkins JW, Tanzi RE. Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity. Neuron. 54: 721-37. PMID 17553422 DOI: 10.1016/j.neuron.2007.05.012  0.92
2007 Vepsäläinen S, Parkinson M, Helisalmi S, Mannermaa A, Soininen H, Tanzi RE, Bertram L, Hiltunen M. Insulin-degrading enzyme is genetically associated with Alzheimer's disease in the Finnish population. Journal of Medical Genetics. 44: 606-8. PMID 17496198 DOI: 10.1136/jmg.2006.048470  0.88
2007 Goin-Kochel RP, Abbacchi A, Constantino JN, Geschwind DH, Brown WT, Bucan M, Buxbaum J, Gilliam TC, Greenberg DA, Ledbetter DH, Miller B, Nelson SF, Pevsner J, Schellenberg GD, Smango-Sprouse CA, ... Tanzi RE, et al. Lack of evidence for increased genetic loading for autism among families of affected females: A replication from family history data in two large samples Autism. 11: 279-286. PMID 17478580 DOI: 10.1177/1362361307076857  0.6
2007 Szatmari P, Paterson AD, Zwaigenbaum L, Roberts W, Brian J, Liu XQ, Vincent JB, Skaug JL, Thompson AP, Senman L, Feuk L, Qian C, Bryson SE, Jones MB, ... ... Tanzi RE, et al. Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nature Genetics. 39: 319-28. PMID 17322880 DOI: 10.1038/ng1985  0.6
2007 Xie Z, Dong Y, Maeda U, Moir RD, Xia W, Culley DJ, Crosby G, Tanzi RE. The inhalation anesthetic isoflurane induces a vicious cycle of apoptosis and amyloid beta-protein accumulation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 1247-54. PMID 17287498 DOI: 10.1523/JNEUROSCI.5320-06.2007  0.88
2007 Kim M, Hersh LB, Leissring MA, Ingelsson M, Matsui T, Farris W, Lu A, Hyman BT, Selkoe DJ, Bertram L, Tanzi RE. Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families. The Journal of Biological Chemistry. 282: 7825-32. PMID 17244626 DOI: 10.1074/jbc.M609168200  0.92
2007 Bertram L, Mullin K, Parkinson M, Hsiao M, Moscarillo TJ, Wagner SL, Becker KD, Velicelebi G, Blacker D, Tanzi RE. Is alpha-T catenin (VR22) an Alzheimer's disease risk gene? Journal of Medical Genetics. 44: e63. PMID 17209133 DOI: 10.1136/jmg.2005.039263  0.6
2007 Bertram L, McQueen MB, Mullin K, Blacker D, Tanzi RE. Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nature Genetics. 39: 17-23. PMID 17192785 DOI: 10.1038/ng1934  0.6
2007 Xie Z, Dong Y, Maeda U, Xia W, Tanzi RE. RNA interference silencing of the adaptor molecules ShcC and Fe65 differentially affect amyloid precursor protein processing and Abeta generation. The Journal of Biological Chemistry. 282: 4318-25. PMID 17170108 DOI: 10.1074/jbc.M609293200  0.92
2007 Perry RT, Wiener H, Harrell LE, Blacker D, Tanzi RE, Bertram L, Bassett SS, Go RC. Follow-up mapping supports the evidence for linkage in the candidate region at 9q22 in the NIMH Alzheimer's disease Genetics Initiative cohort. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 144: 220-7. PMID 17034007 DOI: 10.1002/ajmg.b.30433  0.6
2007 Bertram L, Hsiao M, McQueen MB, Parkinson M, Mullin K, Blacker D, Tanzi RE. The LDLR locus in Alzheimer's disease: a family-based study and meta-analysis of case-control data. Neurobiology of Aging. 28: 18.e1-4. PMID 16378661 DOI: 10.1016/j.neurobiolaging.2005.11.005  0.6
2007 Sisodia SS, Tanzi RE. Alzheimer's disease: Advances in genetics, molecular and cellular biology Alzheimer's Disease: Advances in Genetics, Molecular and Cellular Biology. 1-286. DOI: 10.1007/978-0-387-35135-3  0.36
2006 Xie Z, Dong Y, Maeda U, Moir R, Inouye SK, Culley DJ, Crosby G, Tanzi RE. Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 61: 1300-6. PMID 17234824  0.88
2006 Culley DJ, Yukhananov RY, Xie Z, Gali RR, Tanzi RE, Crosby G. Altered hippocampal gene expression 2 days after general anesthesia in rats. European Journal of Pharmacology. 549: 71-8. PMID 16979155 DOI: 10.1016/j.ejphar.2006.08.028  0.6
2006 Hiltunen M, Lu A, Thomas AV, Romano DM, Kim M, Jones PB, Xie Z, Kounnas MZ, Wagner SL, Berezovska O, Hyman BT, Tesco G, Bertram L, Tanzi RE. Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion. The Journal of Biological Chemistry. 281: 32240-53. PMID 16945923 DOI: 10.1074/jbc.M603106200  0.88
2006 Romano DM, Dong Y, Hiltunen M, Tanzi RE, Xie Z. Artefactual effects of lipid-based cell transfection reagents on AbetaPP processing and Abeta production. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 13: 86-92. PMID 16911962 DOI: 10.1080/13506120600722605  0.6
2006 Thomas AV, Herl L, Spoelgen R, Hiltunen M, Jones PB, Tanzi RE, Hyman BT, Berezovska O. Interaction between presenilin 1 and ubiquilin 1 as detected by fluorescence lifetime imaging microscopy and a high-throughput fluorescent plate reader. The Journal of Biological Chemistry. 281: 26400-7. PMID 16815845 DOI: 10.1074/jbc.M601085200  0.76
2006 Xie Z, Dong Y, Maeda U, Alfille P, Culley DJ, Crosby G, Tanzi RE. The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid beta protein levels. Anesthesiology. 104: 988-94. PMID 16645451 DOI: 10.1097/00000542-200605000-00015  0.92
2006 Xie Z, Tanzi RE. Alzheimer's disease and post-operative cognitive dysfunction. Experimental Gerontology. 41: 346-59. PMID 16564662 DOI: 10.1016/j.exger.2006.01.014  0.6
2006 Liu G, Huang W, Moir RD, Vanderburg CR, Lai B, Peng Z, Tanzi RE, Rogers JT, Huang X. Metal exposure and Alzheimer's pathogenesis. Journal of Structural Biology. 155: 45-51. PMID 16503166 DOI: 10.1016/j.jsb.2005.12.011  0.6
2005 Bertram L, Parkinson M, McQueen MB, Mullin K, Hsiao M, Menon R, Moscarillo TJ, Blacker D, Tanzi RE. Further evidence for LBP-1c/CP2/LSF association in Alzheimer's disease families. Journal of Medical Genetics. 42: 857-62. PMID 16272261 DOI: 10.1136/jmg.2004.024596  0.92
2005 Tanzi RE. Tangles and neurodegenerative disease--a surprising twist. The New England Journal of Medicine. 353: 1853-5. PMID 16251544 DOI: 10.1056/NEJMcibr055003  0.6
2005 Dickerson BC, Salat DH, Greve DN, Chua EF, Rand-Giovannetti E, Rentz DM, Bertram L, Mullin K, Tanzi RE, Blacker D, Albert MS, Sperling RA. Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD. Neurology. 65: 404-11. PMID 16087905 DOI: 10.1212/01.wnl.0000171450.97464.49  0.6
2005 Tesco G, Ginestroni A, Hiltunen M, Kim M, Dolios G, Hyman BT, Wang R, Berezovska O, Tanzi RE. APP substitutions V715F and L720P alter PS1 conformation and differentially affect Abeta and AICD generation. Journal of Neurochemistry. 95: 446-56. PMID 16086682 DOI: 10.1111/j.1471-4159.2005.03381.x  0.6
2005 Tanzi RE. The synaptic Abeta hypothesis of Alzheimer disease. Nature Neuroscience. 8: 977-9. PMID 16047022 DOI: 10.1038/nn0805-977  0.92
2005 Koh YH, von Arnim CA, Hyman BT, Tanzi RE, Tesco G. BACE is degraded via the lysosomal pathway. The Journal of Biological Chemistry. 280: 32499-504. PMID 16033761 DOI: 10.1074/jbc.M506199200  0.92
2005 Slifer MA, Martin ER, Haines JL, Pericak-Vance MA. The ubiquilin 1 gene and Alzheimer's disease. The New England Journal of Medicine. 352: 2752-3; author reply. PMID 15987928 DOI: 10.1056/NEJM200506303522618  0.88
2005 Moir RD, Tanzi RE. LRP-mediated clearance of Abeta is inhibited by KPI-containing isoforms of APP. Current Alzheimer Research. 2: 269-73. PMID 15974929 DOI: 10.2174/1567205053585918  0.88
2005 Bertram L, Tanzi RE. The genetic epidemiology of neurodegenerative disease. The Journal of Clinical Investigation. 115: 1449-57. PMID 15931380 DOI: 10.1172/JCI24761  0.6
2005 Xie Z, Romano DM, Tanzi RE. Effects of RNAi-mediated silencing of PEN-2, APH-1a, and nicastrin on wild-type vs FAD mutant forms of presenilin 1. Journal of Molecular Neuroscience : Mn. 25: 67-77. PMID 15781968 DOI: 10.1385/JMN:25:1:067  0.92
2005 Bertram L, Hsiao M, Mullin K, Parkinson M, Menon R, Moscarillo TJ, Blacker D, Tanzi RE. ACAT1 is not associated with Alzheimer's disease in two independent family-based samples. Molecular Psychiatry. 10: 522-4. PMID 15768051 DOI: 10.1038/  0.6
2005 Bertram L, Hiltunen M, Parkinson M, Ingelsson M, Lange C, Ramasamy K, Mullin K, Menon R, Sampson AJ, Hsiao MY, Elliott KJ, Velicelebi G, Moscarillo T, Hyman BT, Wagner SL, ... ... Tanzi RE, et al. Family-based association between Alzheimer's disease and variants in UBQLN1. The New England Journal of Medicine. 352: 884-94. PMID 15745979 DOI: 10.1056/NEJMoa042765  0.88
2005 Tanzi RE, Bertram L. Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective. Cell. 120: 545-55. PMID 15734686 DOI: 10.1016/j.cell.2005.02.008  0.88
2005 Moir RD, Tseitlin KA, Soscia S, Hyman BT, Irizarry MC, Tanzi RE. Autoantibodies to redox-modified oligomeric Abeta are attenuated in the plasma of Alzheimer's disease patients. The Journal of Biological Chemistry. 280: 17458-63. PMID 15728175 DOI: 10.1074/jbc.M414176200  0.92
2005 Xie Z, Romano DM, Tanzi RE. RNA interference-mediated silencing of X11alpha and X11beta attenuates amyloid beta-protein levels via differential effects on beta-amyloid precursor protein processing. The Journal of Biological Chemistry. 280: 15413-21. PMID 15699037 DOI: 10.1074/jbc.M414353200  0.6
2004 Xie Z, Moir RD, Romano DM, Tesco G, Kovacs DM, Tanzi RE. Hypocapnia induces caspase-3 activation and increases Abeta production. Neuro-Degenerative Diseases. 1: 29-37. PMID 16908971 DOI: 10.1159/000076667  0.92
2004 Dedeoglu A, Cormier K, Payton S, Tseitlin KA, Kremsky JN, Lai L, Li X, Moir RD, Tanzi RE, Bush AI, Kowall NW, Rogers JT, Huang X. Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis. Experimental Gerontology. 39: 1641-9. PMID 15582280 DOI: 10.1016/j.exger.2004.08.016  0.88
2004 Huang X, Atwood CS, Moir RD, Hartshorn MA, Tanzi RE, Bush AI. Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 9: 954-60. PMID 15578276 DOI: 10.1007/s00775-004-0602-8  0.6
2004 Tanzi RE, Moir RD, Wagner SL. Clearance of Alzheimer's Abeta peptide: the many roads to perdition. Neuron. 43: 605-8. PMID 15339642 DOI: 10.1016/j.neuron.2004.08.024  0.88
2004 Bertram L, Tanzi RE. The current status of Alzheimer's disease genetics: what do we tell the patients? Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 50: 385-96. PMID 15304236 DOI: 10.1016/j.phrs.2003.11.018  0.88
2004 Xie Z, Romano DM, Kovacs DM, Tanzi RE. Effects of RNA interference-mediated silencing of gamma-secretase complex components on cell sensitivity to caspase-3 activation. The Journal of Biological Chemistry. 279: 34130-7. PMID 15184387 DOI: 10.1074/jbc.M401094200  0.92
2004 Huang X, Moir RD, Tanzi RE, Bush AI, Rogers JT. Redox-active metals, oxidative stress, and Alzheimer's disease pathology. Annals of the New York Academy of Sciences. 1012: 153-63. PMID 15105262 DOI: 10.1196/annals.1306.012  0.88
2004 Bertram L, Parkinson M, Mullin K, Menon R, Blacker D, Tanzi RE. No association between a previously reported OLR1 3' UTR polymorphism and Alzheimer's disease in a large family sample. Journal of Medical Genetics. 41: 286-8. PMID 15060104  0.88
2004 Farris W, Mansourian S, Leissring MA, Eckman EA, Bertram L, Eckman CB, Tanzi RE, Selkoe DJ. Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein. The American Journal of Pathology. 164: 1425-34. PMID 15039230  0.6
2004 Bertram L, Tanzi RE. Alzheimer's disease: one disorder, too many genes? Human Molecular Genetics. 13: R135-41. PMID 14764623 DOI: 10.1093/hmg/ddh077  0.92
2004 Bertram L, Menon R, Mullin K, Parkinson M, Bradley ML, Blacker D, Tanzi RE. PEN2 is not a genetic risk factor for Alzheimer's disease in a large family sample. Neurology. 62: 304-6. PMID 14745076  0.88
2004 Nagano S, Huang X, Moir RD, Payton SM, Tanzi RE, Bush AI. Peroxidase activity of cyclooxygenase-2 (COX-2) cross-links beta-amyloid (Abeta) and generates Abeta-COX-2 hetero-oligomers that are increased in Alzheimer's disease. The Journal of Biological Chemistry. 279: 14673-8. PMID 14724276 DOI: 10.1074/jbc.M313003200  0.44
2003 Ritchie CW, Bush AI, Mackinnon A, Macfarlane S, Mastwyk M, MacGregor L, Kiers L, Cherny R, Li QX, Tammer A, Carrington D, Mavros C, Volitakis I, Xilinas M, Ames D, ... ... Tanzi RE, et al. Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial. Archives of Neurology. 60: 1685-91. PMID 14676042 DOI: 10.1001/archneur.60.12.1685  0.6
2003 Saunders AJ, Tanzi RE. Welcome to the complex disease world. Alpha2-macroglobulin and Alzheimer's disease. Experimental Neurology. 184: 50-3. PMID 14637079 DOI: 10.1016/j.expneurol.2003.09.004  0.88
2003 Chang Y, Tesco G, Jeong WJ, Lindsley L, Eckman EA, Eckman CB, Tanzi RE, Guénette SY. Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1. The Journal of Biological Chemistry. 278: 51100-7. PMID 14527950 DOI: 10.1074/jbc.M309561200  0.6
2003 Bush AI, Masters CL, Tanzi RE. Copper, beta-amyloid, and Alzheimer's disease: tapping a sensitive connection. Proceedings of the National Academy of Sciences of the United States of America. 100: 11193-4. PMID 14506299 DOI: 10.1073/pnas.2135061100  0.88
2003 Saunders AJ, Bertram L, Mullin K, Sampson AJ, Latifzai K, Basu S, Jones J, Kinney D, MacKenzie-Ingano L, Yu S, Albert MS, Moscarillo TJ, Go RC, Bassett SS, Daly MJ, ... ... Tanzi RE, et al. Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin. Human Molecular Genetics. 12: 2765-76. PMID 12966032 DOI: 10.1093/hmg/ddg310  0.88
2003 Tesco G, Koh YH, Tanzi RE. Caspase activation increases beta-amyloid generation independently of caspase cleavage of the beta-amyloid precursor protein (APP). The Journal of Biological Chemistry. 278: 46074-80. PMID 12960154 DOI: 10.1074/jbc.M307809200  0.92
2003 Bertram L, Saunders AJ, Mullin K, Sampson A, Moscarillo TJ, Basset SS, Go RC, Blacker D, Tanzi RE. No association between marker D10S1423 and Alzheimer's disease. Molecular Psychiatry. 8: 571-3. PMID 12851634 DOI: 10.1038/  0.92
2003 Goldstein LE, Muffat JA, Cherny RA, Moir RD, Ericsson MH, Huang X, Mavros C, Coccia JA, Faget KY, Fitch KA, Masters CL, Tanzi RE, Chylack LT, Bush AI. Cytosolic beta-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease. Lancet. 361: 1258-65. PMID 12699953 DOI: 10.1016/S0140-6736(03)12981-9  0.44
2003 Puglielli L, Tanzi RE, Kovacs DM. Alzheimer's disease: the cholesterol connection. Nature Neuroscience. 6: 345-51. PMID 12658281 DOI: 10.1038/nn0403-345  0.6
2003 Farris W, Mansourian S, Chang Y, Lindsley L, Eckman EA, Frosch MP, Eckman CB, Tanzi RE, Selkoe DJ, Guenette S. Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proceedings of the National Academy of Sciences of the United States of America. 100: 4162-7. PMID 12634421 DOI: 10.1073/pnas.0230450100  0.92
2003 Blacker D, Bertram L, Saunders AJ, Moscarillo TJ, Albert MS, Wiener H, Perry RT, Collins JS, Harrell LE, Go RC, Mahoney A, Beaty T, Fallin MD, Avramopoulos D, Chase GA, ... ... Tanzi RE, et al. Results of a high-resolution genome screen of 437 Alzheimer's disease families. Human Molecular Genetics. 12: 23-32. PMID 12490529 DOI: 10.1093/hmg/ddg007  0.92
2002 Guénette SY, Chang Y, Hyman BT, Tanzi RE, Rebeck GW. Low-density lipoprotein receptor-related protein levels and endocytic function are reduced by overexpression of the FE65 adaptor protein, FE65L1. Journal of Neurochemistry. 82: 755-62. PMID 12358780 DOI: 10.1046/j.1471-4159.2002.01009.x  0.6
2002 Rogers JT, Randall JD, Eder PS, Huang X, Bush AI, Tanzi RE, Venti A, Payton SM, Giordano T, Nagano S, Cahill CM, Moir R, Lahiri DK, Greig N, Sarang SS, et al. Alzheimer's disease drug discovery targeted to the APP mRNA 5'untranslated region. Journal of Molecular Neuroscience : Mn. 19: 77-82. PMID 12212798 DOI: 10.1007/s12031-002-0014-6  0.6
2002 Goto JJ, Tanzi RE. The role of the low-density lipoprotein receptor-related protein (LRP1) in Alzheimer's A beta generation: development of a cell-based model system. Journal of Molecular Neuroscience : Mn. 19: 37-41. PMID 12212791 DOI: 10.1007/s12031-002-0008-4  0.88
2002 Rogers JT, Randall JD, Cahill CM, Eder PS, Huang X, Gunshin H, Leiter L, McPhee J, Sarang SS, Utsuki T, Greig NH, Lahiri DK, Tanzi RE, Bush AI, Giordano T, et al. An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript. The Journal of Biological Chemistry. 277: 45518-28. PMID 12198135 DOI: 10.1074/jbc.M207435200  0.88
2002 Opazo C, Huang X, Cherny RA, Moir RD, Roher AE, White AR, Cappai R, Masters CL, Tanzi RE, Inestrosa NC, Bush AI. Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2). The Journal of Biological Chemistry. 277: 40302-8. PMID 12192006 DOI: 10.1074/jbc.M206428200  0.88
2002 Bush AI, Tanzi RE. The galvanization of beta-amyloid in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 99: 7317-9. PMID 12032279 DOI: 10.1073/pnas.122249699  0.88
2001 Bertram L, Tanzi RE. Of replications and refutations: the status of Alzheimer's disease genetic research. Current Neurology and Neuroscience Reports. 1: 442-50. PMID 11898555  0.6
2001 Bertram L, Tanzi RE. Dancing in the dark? The status of late-onset Alzheimer's disease genetics. Journal of Molecular Neuroscience : Mn. 17: 127-36. PMID 11816786 DOI: 10.1385/JMN:17:2:127  0.6
2001 Tanzi RE, Bertram L. New frontiers in Alzheimer's disease genetics. Neuron. 32: 181-4. PMID 11683989 DOI: 10.1016/S0896-6273(01)00476-7  0.92
2001 Puglielli L, Konopka G, Pack-Chung E, Ingano LA, Berezovska O, Hyman BT, Chang TY, Tanzi RE, Kovacs DM. Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide. Nature Cell Biology. 3: 905-12. PMID 11584272 DOI: 10.1038/ncb1001-905  0.76
2001 Cherny RA, Atwood CS, Xilinas ME, Gray DN, Jones WD, McLean CA, Barnham KJ, Volitakis I, Fraser FW, Kim Y, Huang X, Goldstein LE, Moir RD, Lim JT, Beyreuther K, ... ... Tanzi RE, et al. Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron. 30: 665-76. PMID 11430801 DOI: 10.1016/S0896-6273(01)00317-8  0.6
2001 Kim JW, Chang TS, Lee JE, Huh SH, Yeon SW, Yang WS, Joe CO, Mook-Jung I, Tanzi RE, Kim TW, Choi EJ. Negative regulation of the SAPK/JNK signaling pathway by presenilin 1. The Journal of Cell Biology. 153: 457-63. PMID 11331298  0.44
2001 Rebeck GW, Moir RD, Mui S, Strickland DK, Tanzi RE, Hyman BT. Association of membrane-bound amyloid precursor protein APP with the apolipoprotein E receptor LRP. Brain Research. Molecular Brain Research. 87: 238-45. PMID 11245926 DOI: 10.1016/S0169-328X(01)00006-7  0.6
2001 Sisodia SS, Tanzi RE. Guest editor's introduction: Alzheimer's disease clinical, biological, and therapeutic perspectives Journal of Molecular Neuroscience. 17: 99. DOI: 10.1385/JMN:17:2:99  0.6
2000 Cuajungco MP, Fagét KY, Huang X, Tanzi RE, Bush AI. Metal chelation as a potential therapy for Alzheimer's disease. Annals of the New York Academy of Sciences. 920: 292-304. PMID 11193167  0.88
2000 Ingano LA, Lentini KM, Kovacs I, Tanzi RE, Kovacs DM. Cytoplasmic presenilin aggregates in proteasome inhibitor-treated cells. Annals of the New York Academy of Sciences. 920: 259-60. PMID 11193161  0.76
2000 Tesco G, Tanzi RE. GSK3 beta forms a tetrameric complex with endogenous PS1-CTF/NTF and beta-catenin. Effects of the D257/D385A and FAD-linked mutations. Annals of the New York Academy of Sciences. 920: 227-32. PMID 11193155  0.68
2000 Bertram L, Blacker D, Mullin K, Keeney D, Jones J, Basu S, Yhu S, McInnis MG, Go RC, Vekrellis K, Selkoe DJ, Saunders AJ, Tanzi RE. Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. Science (New York, N.Y.). 290: 2302-3. PMID 11125142 DOI: 10.1126/science.290.5500.2302  0.6
2000 Collins JS, Perry RT, Watson B, Harrell LE, Acton RT, Blacker D, Albert MS, Tanzi RE, Bassett SS, McInnis MG, Campbell RD, Go RC. Association of a haplotype for tumor necrosis factor in siblings with late-onset Alzheimer disease: the NIMH Alzheimer Disease Genetics Initiative. American Journal of Medical Genetics. 96: 823-30. PMID 11121190 DOI: 10.1002/1096-8628(20001204)96:6<823::AID-AJMG26>3.0.CO;2-I  0.88
2000 Bertram L, Blacker D, Crystal A, Mullin K, Keeney D, Jones J, Basu S, Yhu S, Guénette S, McInnis M, Go R, Tanzi R. Candidate genes showing no evidence for association or linkage with Alzheimer's disease using family-based methodologies. Experimental Gerontology. 35: 1353-61. PMID 11113613 DOI: 10.1016/S0531-5565(00)00193-5  0.88
2000 Liu Y, Jones M, Hingtgen CM, Bu G, Laribee N, Tanzi RE, Moir RD, Nath A, He JJ. Uptake of HIV-1 tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands. Nature Medicine. 6: 1380-7. PMID 11100124 DOI: 10.1038/82199  0.88
2000 Guénette SY, Bertram L, Crystal A, Bakondi B, Hyman BT, Rebeck GW, Tanzi RE, Blacker D. Evidence against association of the FE65 gene (APBB1) intron 13 polymorphism in Alzheimer's patients. Neuroscience Letters. 296: 17-20. PMID 11099823 DOI: 10.1016/S0304-3940(00)01607-4  0.44
2000 Buxbaum JD, Lilliehook C, Chan JY, Go RC, Bassett SS, Tanzi RE, Wasco W, Blacker D. Genomic structure, expression pattern, and chromosomal localization of the human calsenilin gene: no association between an exonic polymorphism and Alzheimer's disease. Neuroscience Letters. 294: 135-8. PMID 11072133 DOI: 10.1016/S0304-3940(00)01553-6  0.6
2000 Yoo AS, Cheng I, Chung S, Grenfell TZ, Lee H, Pack-Chung E, Handler M, Shen J, Xia W, Tesco G, Saunders AJ, Ding K, Frosch MP, Tanzi RE, Kim TW. Presenilin-mediated modulation of capacitative calcium entry. Neuron. 27: 561-72. PMID 11055438  0.6
2000 Cherny RA, Barnham KJ, Lynch T, Volitakis I, Li QX, McLean CA, Multhaup G, Beyreuther K, Tanzi RE, Masters CL, Bush AI. Chelation and intercalation: complementary properties in a compound for the treatment of Alzheimer's disease. Journal of Structural Biology. 130: 209-16. PMID 10940226 DOI: 10.1006/jsbi.2000.4285  0.88
2000 Atwood CS, Scarpa RC, Huang X, Moir RD, Jones WD, Fairlie DP, Tanzi RE, Bush AI. Characterization of copper interactions with alzheimer amyloid beta peptides: identification of an attomolar-affinity copper binding site on amyloid beta1-42. Journal of Neurochemistry. 75: 1219-33. PMID 10936205 DOI: 10.1046/j.1471-4159.2000.0751219.x  0.88
2000 Atwood CS, Huang X, Khatri A, Scarpa RC, Kim YS, Moir RD, Tanzi RE, Roher AE, Bush AI. Copper catalyzed oxidation of Alzheimer Abeta. Cellular and Molecular Biology (Noisy-Le-Grand, France). 46: 777-83. PMID 10875439  0.44
2000 Goldstein LE, Leopold MC, Huang X, Atwood CS, Saunders AJ, Hartshorn M, Lim JT, Faget KY, Muffat JA, Scarpa RC, Chylack LT, Bowden EF, Tanzi RE, Bush AI. 3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote alpha-crystallin cross-linking by metal ion reduction. Biochemistry. 39: 7266-75. PMID 10852726 DOI: 10.1021/bi992997s  0.32
2000 Sawamura N, Morishima-Kawashima M, Waki H, Kobayashi K, Kuramochi T, Frosch MP, Ding K, Ito M, Kim TW, Tanzi RE, Oyama F, Tabira T, Ando S, Ihara Y. Mutant presenilin 2 transgenic mice. A large increase in the levels of Abeta 42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin. The Journal of Biological Chemistry. 275: 27901-8. PMID 10846187 DOI: 10.1074/jbc.M004308200  0.44
2000 Huang X, Cuajungco MP, Atwood CS, Moir RD, Tanzi RE, Bush AI. Alzheimer's disease, beta-amyloid protein and zinc. The Journal of Nutrition. 130: 1488S-92S. PMID 10801964  0.44
2000 Killiany RJ, Gomez-Isla T, Moss M, Kikinis R, Sandor T, Jolesz F, Tanzi R, Jones K, Hyman BT, Albert MS. Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease. Annals of Neurology. 47: 430-9. PMID 10762153 DOI: 10.1002/1531-8249(200004)47:4<430::AID-ANA5>3.0.CO;2-I  0.88
2000 Pack-Chung E, Meyers MB, Pettingell WP, Moir RD, Brownawell AM, Cheng I, Tanzi RE, Kim TW. Presenilin 2 interacts with sorcin, a modulator of the ryanodine receptor. The Journal of Biological Chemistry. 275: 14440-5. PMID 10748169 DOI: 10.1074/jbc.M909882199  0.88
2000 Tanzi RE. Alzheimer's disease risk and the interleukin-1 genes. Annals of Neurology. 47: 283-5. PMID 10716246 DOI: 10.1002/1531-8249(200003)47:3<283::AID-ANA2>3.0.CO;2-N  0.88
2000 Ulery PG, Beers J, Mikhailenko I, Tanzi RE, Rebeck GW, Hyman BT, Strickland DK. Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease. The Journal of Biological Chemistry. 275: 7410-5. PMID 10702315 DOI: 10.1074/jbc.275.10.7410  0.44
2000 Abbenante G, Kovacs DM, Leung DL, Craik DJ, Tanzi RE, Fairlie DP. Inhibitors of beta-amyloid formation based on the beta-secretase cleavage site. Biochemical and Biophysical Research Communications. 268: 133-5. PMID 10652226 DOI: 10.1006/bbrc.2000.2098  0.6
1999 Cuajungco MP, Lees GJ, Kydd RR, Tanzi RE, Bush AI. Zinc and Alzheimer's Disease: An Update. Nutritional Neuroscience. 2: 191-208. PMID 27415572 DOI: 10.1080/1028415X.1999.11747277  0.88
1999 Huang X, Cuajungco MP, Atwood CS, Hartshorn MA, Tyndall JD, Hanson GR, Stokes KC, Leopold M, Multhaup G, Goldstein LE, Scarpa RC, Saunders AJ, Lim J, Moir RD, Glabe C, ... ... Tanzi RE, et al. Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction. The Journal of Biological Chemistry. 274: 37111-6. PMID 10601271 DOI: 10.1074/jbc.274.52.37111  0.6
1999 Kovacs DM, Mancini R, Henderson J, Na SJ, Schmidt SD, Kim TW, Tanzi RE. Staurosporine-induced activation of caspase-3 is potentiated by presenilin 1 familial Alzheimer's disease mutations in human neuroglioma cells. Journal of Neurochemistry. 73: 2278-85. PMID 10582585 DOI: 10.1046/j.1471-4159.1999.0732278.x  0.44
1999 Guénette SY, Tanzi RE. Progress toward valid transgenic mouse models for Alzheimer's disease. Neurobiology of Aging. 20: 201-11. PMID 10537029 DOI: 10.1016/S0197-4580(99)00042-1  0.88
1999 Guénette SY, Chen J, Ferland A, Haass C, Capell A, Tanzi RE. hFE65L influences amyloid precursor protein maturation and secretion. Journal of Neurochemistry. 73: 985-93. PMID 10461887 DOI: 10.1046/j.1471-4159.1999.0730985.x  0.88
1999 Cherny RA, Legg JT, McLean CA, Fairlie DP, Huang X, Atwood CS, Beyreuther K, Tanzi RE, Masters CL, Bush AI. Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion. The Journal of Biological Chemistry. 274: 23223-8. PMID 10438495 DOI: 10.1074/jbc.274.33.23223  0.88
1999 Moir RD, Atwood CS, Huang X, Tanzi RE, Bush AI. Mounting evidence for the involvement of zinc and copper in Alzheimer's disease. European Journal of Clinical Investigation. 29: 569-70. PMID 10411660 DOI: 10.1046/j.1365-2362.1999.00472.x  0.44
1999 Huang X, Atwood CS, Hartshorn MA, Multhaup G, Goldstein LE, Scarpa RC, Cuajungco MP, Gray DN, Lim J, Moir RD, Tanzi RE, Bush AI. The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction. Biochemistry. 38: 7609-16. PMID 10386999 DOI: 10.1021/bi990438f  0.88
1999 Moir RD, Atwood CS, Romano DM, Laurans MH, Huang X, Bush AI, Smith JD, Tanzi RE. Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A beta using physiological concentrations. Biochemistry. 38: 4595-603. PMID 10194381 DOI: 10.1021/bi982437d  0.6
1999 Atwood CS, Huang X, Moir RD, Tanzi RE, Bush AI. Role of free radicals and metal ions in the pathogenesis of Alzheimer's disease. Metal Ions in Biological Systems. 36: 309-64. PMID 10093929  0.88
1999 Huang X, Atwood CS, Hartshorn MA, Multhaup G, Goldstein LE, Scarpa RC, Cuajungco MP, Gray DN, Lim J, Moir RD, Tanzi RE, Bush AI. The Aβ peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction Biochemistry. 38: X-7616.  0.88
1998 Price DL, Tanzi RE, Borchelt DR, Sisodia SS. Alzheimer's disease: genetic studies and transgenic models. Annual Review of Genetics. 32: 461-93. PMID 9928488 DOI: 10.1146/annurev.genet.32.1.461  0.88
1998 Tesco G, Kim TW, Diehlmann A, Beyreuther K, Tanzi RE. Abrogation of the presenilin 1/beta-catenin interaction and preservation of the heterodimeric presenilin 1 complex following caspase activation. The Journal of Biological Chemistry. 273: 33909-14. PMID 9852041  0.68
1998 Liao A, Nitsch RM, Greenberg SM, Finckh U, Blacker D, Albert M, Rebeck GW, Gomez-Isla T, Clatworthy A, Binetti G, Hock C, Mueller-Thomsen T, Mann U, Zuchowski K, Beisiegel U, ... ... Tanzi RE, et al. Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease. Human Molecular Genetics. 7: 1953-6. PMID 9811940 DOI: 10.1093/hmg/7.12.1953  0.6
1998 Kim TW, Tanzi RE. Neuronal intranuclear inclusions in polyglutamine diseases: nuclear weapons or nuclear fallout? Neuron. 21: 657-9. PMID 9808451  0.44
1998 Kovacs DM, Tanzi RE. Monogenic determinants of familial Alzheimer's disease: presenilin-1 mutations. Cellular and Molecular Life Sciences : Cmls. 54: 902-9. PMID 9791532 DOI: 10.1007/s000180050219  0.92
1998 Bush AI, Tanzi RE. Alzheimer disease-related abnormalities of amyloid beta precursor protein isoforms in the platelet: the brain's delegate in the periphery? Archives of Neurology. 55: 1179-80. PMID 9740110 DOI: 10.1001/archneur.55.9.1179  0.88
1998 McNamara MJ, Ruff CT, Wasco W, Tanzi RE, Thinakaran G, Hyman BT. Immunohistochemical and in situ analysis of amyloid precursor-like protein-1 and amyloid precursor-like protein-2 expression in Alzheimer disease and aged control brains. Brain Research. 804: 45-51. PMID 9729270 DOI: 10.1016/S0006-8993(98)00653-2  0.6
1998 Etcheberrigaray R, Hirashima N, Nee L, Prince J, Govoni S, Racchi M, Tanzi RE, Alkon DL. Calcium responses in fibroblasts from asymptomatic members of Alzheimer's disease families. Neurobiology of Disease. 5: 37-45. PMID 9702786 DOI: 10.1006/nbdi.1998.0176  0.44
1998 Blacker D, Wilcox MA, Laird NM, Rodes L, Horvath SM, Go RC, Perry R, Watson B, Bassett SS, McInnis MG, Albert MS, Hyman BT, Tanzi RE. Alpha-2 macroglobulin is genetically associated with Alzheimer disease. Nature Genetics. 19: 357-60. PMID 9697696 DOI: 10.1038/1243  0.88
1998 Xia MQ, Berezovska O, Kim TW, Xia WM, Liao A, Tanzi RE, Selkoe D, Hyman BT. Lack of specific association of presenilin 1 (PS-1) protein with plaques and tangles in Alzheimer's disease. Journal of the Neurological Sciences. 158: 15-23. PMID 9667772  0.48
1998 Atwood CS, Moir RD, Huang X, Scarpa RC, Bacarra NM, Romano DM, Hartshorn MA, Tanzi RE, Bush AI. Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis. The Journal of Biological Chemistry. 273: 12817-26. PMID 9582309 DOI: 10.1074/jbc.273.21.12817  0.88
1998 Hock C, Golombowski S, Müller-Spahn F, Naser W, Beyreuther K, Mönning U, Schenk D, Vigo-Pelfrey C, Bush AM, Moir R, Tanzi RE, Growdon JH, Nitsch RM. Cerebrospinal fluid levels of amyloid precursor protein and amyloid beta-peptide in Alzheimer's disease and major depression - inverse correlation with dementia severity. European Neurology. 39: 111-8. PMID 9520072 DOI: 10.1159/000007917  0.44
1998 Blacker D, Tanzi RE. The genetics of Alzheimer disease: current status and future prospects. Archives of Neurology. 55: 294-6. PMID 9520001 DOI: 10.1001/archneur.55.3.294  0.6
1998 Moir RD, Lynch T, Bush AI, Whyte S, Henry A, Portbury S, Multhaup G, Small DH, Tanzi RE, Beyreuther K, Masters CL. Relative increase in Alzheimer's disease of soluble forms of cerebral Abeta amyloid protein precursor containing the Kunitz protease inhibitory domain. The Journal of Biological Chemistry. 273: 5013-9. PMID 9478949 DOI: 10.1074/jbc.273.9.5013  0.6
1997 Kim TW, Tanzi RE. Presenilins and Alzheimer's disease. Current Opinion in Neurobiology. 7: 683-8. PMID 9384549 DOI: 10.1016/S0959-4388(97)80089-X  0.88
1997 Finch CE, Tanzi RE. Genetics of aging. Science (New York, N.Y.). 278: 407-11. PMID 9334291 DOI: 10.1126/science.278.5337.407  0.44
1997 Huang X, Atwood CS, Moir RD, Hartshorn MA, Vonsattel JP, Tanzi RE, Bush AI. Zinc-induced Alzheimer's Abeta1-40 aggregation is mediated by conformational factors. The Journal of Biological Chemistry. 272: 26464-70. PMID 9334223 DOI: 10.1074/jbc.272.42.26464  0.88
1997 Kim TW, Pettingell WH, Jung YK, Kovacs DM, Tanzi RE. Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. Science (New York, N.Y.). 277: 373-6. PMID 9219695 DOI: 10.1126/science.277.5324.373  0.88
1997 Gómez-Isla T, Wasco W, Pettingell WP, Gurubhagavatula S, Schmidt SD, Jondro PD, McNamara M, Rodes LA, DiBlasi T, Growdon WB, Seubert P, Schenk D, Growdon JH, Hyman BT, Tanzi RE. A novel presenilin-1 mutation: increased beta-amyloid and neurofibrillary changes. Annals of Neurology. 41: 809-13. PMID 9189043 DOI: 10.1002/ana.410410618  0.88
1997 Seeger M, Nordstedt C, Petanceska S, Kovacs DM, Gouras GK, Hahne S, Fraser P, Levesque L, Czernik AJ, George-Hyslop PS, Sisodia SS, Thinakaran G, Tanzi RE, Greengard P, Gandy S. Evidence for phosphorylation and oligomeric assembly of presenilin 1. Proceedings of the National Academy of Sciences of the United States of America. 94: 5090-4. PMID 9144195 DOI: 10.1073/pnas.94.10.5090  0.88
1997 Kim TW, Pettingell WH, Hallmark OG, Moir RD, Wasco W, Tanzi RE. Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells. The Journal of Biological Chemistry. 272: 11006-10. PMID 9110991 DOI: 10.1074/jbc.272.17.11006  0.6
1997 Suzuki T, Ando K, Isohara T, Oishi M, Lim GS, Satoh Y, Wasco W, Tanzi RE, Nairn AC, Greengard P, Gandy SE, Kirino Y. Phosphorylation of Alzheimer beta-amyloid precursor-like proteins. Biochemistry. 36: 4643-9. PMID 9109675 DOI: 10.1021/bi962618k  0.88
1997 Blacker D, Haines JL, Rodes L, Terwedow H, Go RC, Harrell LE, Perry RT, Bassett SS, Chase G, Meyers D, Albert MS, Tanzi R. ApoE-4 and age at onset of Alzheimer's disease: the NIMH genetics initiative. Neurology. 48: 139-47. PMID 9008509  0.88
1997 Berezovska O, Xia MQ, Page K, Wasco W, Tanzi RE, Hyman BT. Developmental regulation of presenilin mRNA expression parallels notch expression. Journal of Neuropathology and Experimental Neurology. 56: 40-4. PMID 8990127  0.88
1996 Tanzi RE, Kovacs DM, Kim TW, Moir RD, Guenette SY, Wasco W. The gene defects responsible for familial Alzheimer's disease. Neurobiology of Disease. 3: 159-68. PMID 8980016 DOI: 10.1006/nbdi.1996.0016  0.44
1996 Page K, Hollister R, Tanzi RE, Hyman BT. In situ hybridization analysis of presenilin 1 mRNA in Alzheimer disease and in lesioned rat brain. Proceedings of the National Academy of Sciences of the United States of America. 93: 14020-4. PMID 8943053 DOI: 10.1073/pnas.93.24.14020  0.88
1996 Guénette SY, Chen J, Jondro PD, Tanzi RE. Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein. Proceedings of the National Academy of Sciences of the United States of America. 93: 10832-7. PMID 8855266 DOI: 10.1073/pnas.93.20.10832  0.88
1996 Cook DG, Sung JC, Golde TE, Felsenstein KM, Wojczyk BS, Tanzi RE, Trojanowski JQ, Lee VM, Doms RW. Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites. Proceedings of the National Academy of Sciences of the United States of America. 93: 9223-8. PMID 8799182 DOI: 10.1073/pnas.93.17.9223  0.44
1996 Irizarry MC, Kim TW, McNamara M, Tanzi RE, George JM, Clayton DF, Hyman BT. Characterization of the precursor protein of the non-A beta component of senile plaques (NACP) in the human central nervous system. Journal of Neuropathology and Experimental Neurology. 55: 889-95. PMID 8759778  0.88
1996 Kovacs DM, Fausett HJ, Page KJ, Kim TW, Moir RD, Merriam DE, Hollister RD, Hallmark OG, Mancini R, Felsenstein KM, Hyman BT, Tanzi RE, Wasco W. Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells. Nature Medicine. 2: 224-9. PMID 8574969 DOI: 10.1038/nm0296-224  0.88
1995 Bush AI, Moir RD, Rosenkranz KM, Tanzi RE. Response. Science (New York, N.Y.). 268: 1921-3. PMID 17797535 DOI: 10.1126/science.268.5219.1921  0.88
1995 Kovacs DM, Wasco W, Witherby J, Felsenstein KM, Brunel F, Roeder RG, Tanzi RE. The upstream stimulatory factor functionally interacts with the Alzheimer amyloid beta-protein precursor gene. Human Molecular Genetics. 4: 1527-33. PMID 8541835 DOI: 10.1093/hmg/4.9.1527  0.88
1995 Tanzi RE. A promising animal model of Alzheimer's disease. The New England Journal of Medicine. 332: 1512-3. PMID 7739692 DOI: 10.1056/NEJM199506013322212  0.88
1995 Locke PA, Conneally PM, Tanzi RE, Gusella JF, Haines JL. Apolipoprotein E4 allele and Alzheimer disease: examination of allelic association and effect on age at onset in both early- and late-onset cases. Genetic Epidemiology. 12: 83-92. PMID 7713402 DOI: 10.1002/gepi.1370120108  0.88
1995 Webster MT, Groome N, Francis PT, Pearce BR, Sherriff FE, Thinakaran G, Felsenstein KM, Wasco W, Tanzi RE, Bowen DM. A novel protein, amyloid precursor-like protein 2, is present in human brain, cerebrospinal fluid and conditioned media. The Biochemical Journal. 310: 95-9. PMID 7646477  0.88
1995 Levy-Lahad E, Wasco W, Poorkaj P, Romano DM, Oshima J, Pettingell WH, Yu CE, Jondro PD, Schmidt SD, Wang K. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science (New York, N.Y.). 269: 973-7. PMID 7638622  0.88
1995 Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Rimmler JB, Locke PA, Conneally PM, Schmader KE, Tanzi RE. Apolipoprotein E, survival in Alzheimer's disease patients, and the competing risks of death and Alzheimer's disease. Neurology. 45: 1323-8. PMID 7617191  0.88
1995 Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, Tsuda T, Mar L, Foncin JF, Bruni AC, Montesi MP, ... ... Tanzi RE, et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature. 375: 754-60. PMID 7596406 DOI: 10.1038/375754a0  0.88
1995 Wasco W, Pettingell WP, Jondro PD, Schmidt SD, Gurubhagavatula S, Rodes L, DiBlasi T, Romano DM, Guenette SY, Kovacs DM. Familial Alzheimer's chromosome 14 mutations. Nature Medicine. 1: 848. PMID 7585193  0.88
1995 Hyman BT, Tanzi R. Molecular epidemiology of Alzheimer's disease New England Journal of Medicine. 333: 1283-1284. PMID 7566008 DOI: 10.1056/NEJM199511093331910  0.88
1995 Kounnas MZ, Moir RD, Rebeck GW, Bush AI, Argraves WS, Tanzi RE, Hyman BT, Strickland DK. LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation. Cell. 82: 331-40. PMID 7543026 DOI: 10.1016/0092-8674(95)90320-8  0.88
1995 Kim TW, Wu K, Xu JL, McAuliffe G, Tanzi RE, Wasco W, Black IB. Selective localization of amyloid precursor-like protein 1 in the cerebral cortex postsynaptic density. Brain Research. Molecular Brain Research. 32: 36-44. PMID 7494461 DOI: 10.1016/0169-328X(95)00328-P  0.88
1995 Bush AI, Moir RD, Rosenkranz KM, Tanzi RE. Zinc and Alzheimer's disease [8] Science. 268: 1921-1923.  0.88
1994 Slunt HH, Thinakaran G, Von Koch C, Lo AC, Tanzi RE, Sisodia SS. Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP). The Journal of Biological Chemistry. 269: 2637-44. PMID 8300594  0.88
1994 Bush AI, Pettingell WH, Paradis MD, Tanzi RE. Modulation of A beta adhesiveness and secretase site cleavage by zinc. The Journal of Biological Chemistry. 269: 12152-8. PMID 8163520  0.88
1994 Bush AI, Pettingell WH, Multhaup G, d Paradis M, Vonsattel JP, Gusella JF, Beyreuther K, Masters CL, Tanzi RE. Rapid induction of Alzheimer A beta amyloid formation by zinc. Science (New York, N.Y.). 265: 1464-7. PMID 8073293  0.88
1994 Ali G, Wasco W, Cai X, Szabo P, Sheu KF, Cooper AJ, Gaston SM, Gusella JF, Tanzi RE, Blass JP. Isolation, characterization, and mapping of gene encoding dihydrolipoyl succinyltransferase (E2k) of human alpha-ketoglutarate dehydrogenase complex. Somatic Cell and Molecular Genetics. 20: 99-105. PMID 8009371 DOI: 10.1007/BF02290679  0.88
1994 Cai X, Szabo P, Ali G, Tanzi RE, Blass JP. Pseudogene of dihydrolipoyl succinyltransferase (E2k) found by PCR amplification and direct sequencing of rodent-human cell hybrid DNAs. Somatic Cell and Molecular Genetics. 20: 339-43. PMID 7974008 DOI: 10.1007/BF02254722  0.88
1994 Gregor P, Gaston SM, Yang X, O'Regan JP, Rosen DR, Tanzi RE, Patterson D, Haines JL, Horvitz HR, Uhl GR. Genetic and physical mapping of the GLUR5 glutamate receptor gene on human chromosome 21. Human Genetics. 94: 565-70. PMID 7959697 DOI: 10.1007/BF00211029  0.88
1994 Bush AI, Pettingell WH, de Paradis M, Tanzi RE, Wasco W. The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily. The Journal of Biological Chemistry. 269: 26618-21. PMID 7929392  0.88
1994 Tanzi RE, Bush AI, Wasco W. Genetic studies of Alzheimer's disease: lessons learned and future imperatives. Neurobiology of Aging. 15: S145-8. PMID 7700440 DOI: 10.1016/0197-4580(94)90193-7  0.88
1993 Tanzi RE, Wenniger JJ, Hyman BT. Cellular specificity and regional distribution of amyloid beta protein precursor alternative transcripts are unaltered in Alzheimer hippocampal formation. Brain Research. Molecular Brain Research. 18: 246-52. PMID 8497186 DOI: 10.1016/0169-328X(93)90196-V  0.88
1993 Wasco W, Brook JD, Tanzi RE. The amyloid precursor-like protein (APLP) gene maps to the long arm of human chromosome 19. Genomics. 15: 237-9. PMID 8432545 DOI: 10.1006/geno.1993.1047  0.88
1993 Pericak-Vance MA, St George-Hyslop PH, Gaskell PC, Growdon J, Crain BJ, Hulette C, Gusella JF, Yamaoka L, Tanzi RE, Roses AD. Linkage analysis in familial Alzheimer disease: description of the Duke and Boston data sets. Genetic Epidemiology. 10: 361-4. PMID 8314027 DOI: 10.1002/gepi.1370100605  0.88
1993 Tanzi RE, Petrukhin K, Chernov I, Pellequer JL, Wasco W, Ross B, Romano DM, Parano E, Pavone L, Brzustowicz LM. The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene. Nature Genetics. 5: 344-50. PMID 8298641 DOI: 10.1038/ng1293-344  0.88
1993 Petrukhin K, Fischer SG, Pirastu M, Tanzi RE, Chernov I, Devoto M, Brzustowicz LM, Cayanis E, Vitale E, Russo JJ. Mapping, cloning and genetic characterization of the region containing the Wilson disease gene. Nature Genetics. 5: 338-43. PMID 8298640 DOI: 10.1038/ng1293-338  0.88
1993 Wasco W, Peppercorn J, Tanzi RE. Search for the genes responsible for familial Alzheimer's disease. Annals of the New York Academy of Sciences. 695: 203-8. PMID 8239284 DOI: 10.1111/j.1749-6632.1993.tb23053.x  0.88
1993 Rogaev EI, Lukiw WJ, Vaula G, Haines JL, Rogaeva EA, Tsuda T, Alexandrova N, Liang Y, Mortilla M, Amaducci L, Bergamini L, Bruni AC, Foncin JF, Macciardi F, Montesi M, ... ... Tanzi R, et al. Analysis of the c-FOS gene on chromosome 14 and the promoter of the amyloid precursor protein gene in familial Alzheimer's disease. Neurology. 43: 2275-9. PMID 8232942  0.88
1993 Wasco W, Gurubhagavatula S, Paradis MD, Romano DM, Sisodia SS, Hyman BT, Neve RL, Tanzi RE. Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor. Nature Genetics. 5: 95-100. PMID 8220435 DOI: 10.1038/ng0993-95  0.88
1993 Lamb BT, Sisodia SS, Lawler AM, Slunt HH, Kitt CA, Kearns WG, Pearson PL, Price DL, Gearhart JD. Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected]. Nature Genetics. 5: 22-30. PMID 8220418 DOI: 10.1038/ng0993-22  0.36
1993 Tanzi R, Gaston S, Bush A, Romano D, Pettingell W, Peppercorn J, Paradis M, Gurubhagavatula S, Jenkins B, Wasco W. Genetic heterogeneity of gene defects responsible for familial Alzheimer disease. Genetica. 91: 255-63. PMID 8125274 DOI: 10.1007/BF01436002  0.88
1993 Locke PA, MacDonald ME, Srinidhi J, Gilliam TC, Tanzi RE, Conneally PM, Wexler NS, Haines JL, Gusella JF. A genetic linkage map of the chromosome 4 short arm. Somatic Cell and Molecular Genetics. 19: 95-101. PMID 8096345 DOI: 10.1007/BF01233958  0.88
1993 Hyman BT, Wenniger JJ, Tanzi RE. Nonisotopic in situ hybridization of amyloid beta protein precursor in Alzheimer's disease: expression in neurofibrillary tangle bearing neurons and in the microenvironment surrounding senile plaques. Brain Research. Molecular Brain Research. 18: 253-8. PMID 7684484 DOI: 10.1016/0169-328X(93)90197-W  0.88
1992 Hyman BT, Tanzi RE, Marzloff K, Barbour R, Schenk D. Kunitz protease inhibitor-containing amyloid beta protein precursor immunoreactivity in Alzheimer's disease. Journal of Neuropathology and Experimental Neurology. 51: 76-83. PMID 1740675  0.88
1992 Tanzi RE, Vaula G, Romano DM, Mortilla M, Huang TL, Tupler RG, Wasco W, Hyman BT, Haines JL, Jenkins BJ. Assessment of amyloid beta-protein precursor gene mutations in a large set of familial and sporadic Alzheimer disease cases. American Journal of Human Genetics. 51: 273-82. PMID 1642228  0.88
1992 Hyman BT, Tanzi RE. Amyloid, dementia and Alzheimer's disease. Current Opinion in Neurology and Neurosurgery. 5: 88-93. PMID 1623244  0.36
1992 Tanzi RE, Romano DM, Berger R, Buraczynska MJ, Gaston SM, Kurnit DM, Patterson D, Gusella JF, Stewart GD. Sequence-tagged sites (STSs) for a set of mapped markers on chromosome 21. Genomics. 14: 498-502. PMID 1427866 DOI: 10.1016/S0888-7543(05)80251-4  0.88
1992 Tanzi RE, Watkins PC, Stewart GD, Wexler NS, Gusella JF, Haines JL. A genetic linkage map of human chromosome 21: analysis of recombination as a function of sex and age. American Journal of Human Genetics. 50: 551-8. PMID 1347193  0.76
1992 Haines JL, Trofatter JA, Tanzi RE, Watkins P, Wexler NS, Conneally PM, Gusella JF. Chromosome 21 genetic linkage data set based on the Venezuelan reference pedigree. Cytogenetics and Cell Genetics. 59: 88-9. PMID 1346592  0.88
1992 Wasco W, Bupp K, Magendantz M, Gusella JF, Tanzi RE, Solomon F. Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor. Proceedings of the National Academy of Sciences of the United States of America. 89: 10758-62. PMID 1279693  0.88
1991 Tanzi RE, George-Hyslop PS, Gusella JF. Molecular genetics of Alzheimer disease amyloid. The Journal of Biological Chemistry. 266: 20579-82. PMID 1939107  0.76
1991 Tanzi RE, Hyman BT. Alzheimer's mutation. Nature. 350: 564. PMID 1901961 DOI: 10.1038/350564a0  0.36
1991 Tanzi RE, Hyman BT. Studies of amyloid beta-protein precursor expression in Alzheimer's disease. Annals of the New York Academy of Sciences. 640: 149-54. PMID 1776733  0.36
1991 Abe K, St George-Hyslop PH, Tanzi RE, Kogure K. Induction of amyloid precursor protein mRNA after heat shock in cultured human lymphoblastoid cells. Neuroscience Letters. 125: 169-71. PMID 1652710  0.32
1990 Tanzi RE, Haines JL, Gusella JF. Detailed genetic linkage map of human chromosome 21: patterns of recombination according to age and sex. Progress in Clinical and Biological Research. 360: 15-26. PMID 2247506  0.76
1990 Palmert MR, Podlisny MB, Golde TE, Cohen ML, Kovacs DM, Tanzi RE, Gusella JF, Whitehouse PJ, Witker DS, Oltersdorf T. Analysis of the beta-amyloid protein precursor of Alzheimer's disease: mRNAs and protein products. Advances in Neurology. 51: 181-4. PMID 2104687  0.88
1989 St George-Hyslop PH, Tanzi RE, Haines JL, Polinsky RJ, Farrer L, Myers RH, Gusella JF. Molecular genetics of familial Alzheimer's disease. European Neurology. 29: 25-7. PMID 2693103  0.76
1989 St George-Hyslop PH, Myers RH, Haines JL, Farrer LA, Tanzi RE, Abe K, James MF, Conneally PM, Polinsky RJ, Gusella JF. Familial Alzheimer's disease: progress and problems. Neurobiology of Aging. 10: 417-25. PMID 2682321 DOI: 10.1016/0197-4580(89)90082-1  0.88
1989 St George-Hyslop PH, Haines JL, Polinsky RJ, Tanzi RE, Farrer L, Myers RH, Gusella JF. Molecular genetics of familial Alzheimer's disease. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 16: 465-7. PMID 2680005  0.76
1989 Conneally PM, Haines JL, Tanzi RE, Wexler NS, Penchaszadeh GK, Harper PS, Folstein SE, Cassiman JJ, Myers RH, Young AB. Huntington disease: no evidence for locus heterogeneity. Genomics. 5: 304-8. PMID 2571579 DOI: 10.1016/0888-7543(89)90062-1  0.6
1989 Van Keuren ML, Stewart GD, Bradley CM, Kurnit DM, Neve RL, Watkins PC, Tanzi RE, Gusella JF, Patterson D. Characterization of an unusual and complex chromosome 21 rearrangement using somatic cell genetics and cloned DNA probes. American Journal of Medical Genetics. 33: 369-75. PMID 2529766 DOI: 10.1002/ajmg.1320330316  0.76
1989 Palmert MR, Podlisny MB, Golde TE, Cohen ML, Kovacs DM, Tanzi RE, Gusella JF, Whitehouse PJ, Witker DS, Oltersdorf T. The beta amyloid protein precursor: mRNAs, membrane-associated forms, and soluble derivatives. Progress in Clinical and Biological Research. 317: 971-84. PMID 2513588  0.88
1989 Tanzi RE, St George-Hyslop PH, Gusella JF. Molecular genetic approaches to Alzheimer's disease. Trends in Neurosciences. 12: 152-8. PMID 2470173 DOI: 10.1016/0166-2236(89)90055-6  0.76
1988 Sacchi N, Cheng SV, Tanzi RE, Gusella JF, Drabkin HA, Patterson D, Haines JH, Papas TS. The ETS genes on chromosome 21 are distal to the breakpoint of the acute myelogenous leukemia translocation (8;21). Genomics. 3: 110-6. PMID 3267212  0.76
1988 Tanzi RE, Haines JL, Watkins PC, Stewart GD, Wallace MR, Hallewell R, Wong C, Wexler NS, Conneally PM, Gusella JF. Genetic linkage map of human chromosome 21. Genomics. 3: 129-36. PMID 2906323 DOI: 10.1016/0888-7543(88)90143-7  0.88
1988 Phelan MC, Morton CC, Stevenson RE, Tanzi RE, Stewart GD, Watkins PC, Gusella JF, Amos JA. Molecular and cytogenetic characterization of a de novo t(5p;21q) in a patient previously diagnosed as monosomy 21. American Journal of Human Genetics. 43: 511-9. PMID 2902789  0.88
1988 Cheng SV, Nadeau JH, Tanzi RE, Watkins PC, Jagadesh J, Taylor BA, Haines JL, Sacchi N, Gusella JF. Comparative mapping of DNA markers from the familial Alzheimer disease and Down syndrome regions of human chromosome 21 to mouse chromosomes 16 and 17. Proceedings of the National Academy of Sciences of the United States of America. 85: 6032-6. PMID 2901095  0.76
1988 Tanzi RE, McClatchey AI, Lamperti ED, Villa-Komaroff L, Gusella JF, Neve RL. Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease. Nature. 331: 528-30. PMID 2893290 DOI: 10.1038/331528a0  0.76
1988 Palmert MR, Golde TE, Cohen ML, Kovacs DM, Tanzi RE, Gusella JF, Usiak MF, Younkin LH, Younkin SG. Amyloid protein precursor messenger RNAs: differential expression in Alzheimer's disease. Science (New York, N.Y.). 241: 1080-4. PMID 2457949  0.88
1987 Cheng SV, Gross Lugo T, Tanzi RE, Whitney JB, Fournier RE, Gusella JF. Chromosomal localization of the mouse homolog of the Huntington's disease linked G8 (D4S10) marker. Dna (Mary Ann Liebert, Inc.). 6: 401-7. PMID 2890502  0.88
1987 Tanzi RE, Bird ED, Latt SA, Neve RL. The amyloid beta protein gene is not duplicated in brains from patients with Alzheimer's disease. Science (New York, N.Y.). 238: 666-9. PMID 2890207  0.36
1987 St George-Hyslop PH, Tanzi RE, Polinsky RJ, Neve RL, Pollen D, Drachman D, Growdon J, Cupples LA, Nee L, Myers RH. Absence of duplication of chromosome 21 genes in familial and sporadic Alzheimer's disease. Science (New York, N.Y.). 238: 664-6. PMID 2890206  0.88
1987 Tanzi RE, St George-Hyslop PH, Haines JL, Polinsky RJ, Nee L, Foncin JF, Neve RL, McClatchey AI, Conneally PM, Gusella JF. The genetic defect in familial Alzheimer's disease is not tightly linked to the amyloid beta-protein gene. Nature. 329: 156-7. PMID 2888020 DOI: 10.1038/329156a0  0.88
1987 Gilliam TC, Tanzi RE, Haines JL, Bonner TI, Faryniarz AG, Hobbs WJ, MacDonald ME, Cheng SV, Folstein SE, Conneally PM. Localization of the Huntington's disease gene to a small segment of chromosome 4 flanked by D4S10 and the telomere. Cell. 50: 565-71. PMID 2886227 DOI: 10.1016/0092-8674(87)90029-8  0.76
1987 Watkins PC, Eddy R, Beck AK, Vellucci V, Leverone B, Tanzi RE, Gusella JF, Shows TB. DNA sequence and regional assignment of the human follicle-stimulating hormone beta-subunit gene to the short arm of human chromosome 11. Dna (Mary Ann Liebert, Inc.). 6: 205-12. PMID 2885163  0.76
1987 Watkins PC, Tanzi RE, Cheng SV, Gusella JF. Molecular genetics of human chromosome 21. Journal of Medical Genetics. 24: 257-70. PMID 2884319  0.76
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