Brigitte L. Kieffer - Publications

Affiliations: 
Institut de génétique et de biologie moléculaire et cellulaire, France, Illkirch-Graffenstaden, France 
Area:
Opioid system

214 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Ehrlich AT, Semache M, Gross F, Da Fonte DF, Runtz L, Colley C, Mezni A, Le Gouill C, Lukasheva V, Hogue M, Darcq E, Bouvier M, Kieffer BL. Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons. Iscience. 14: 47-57. PMID 30925410 DOI: 10.1016/j.isci.2019.03.011  0.96
2019 Ehrlich AT, Kieffer BL, Darcq E. Current strategies toward safer mu opioid receptor drugs for pain management. Expert Opinion On Therapeutic Targets. PMID 30802415 DOI: 10.1080/14728222.2019.1586882  0.96
2018 Ehrlich AT, Maroteaux G, Robe A, Venteo L, Nasseef MT, van Kempen LC, Mechawar N, Turecki G, Darcq E, Kieffer BL. Expression map of 78 brain-expressed mouse orphan GPCRs provides a translational resource for neuropsychiatric research. Communications Biology. 1: 102. PMID 30271982 DOI: 10.1038/s42003-018-0106-7  0.96
2018 Jin C, Decker AM, Makhijani VH, Besheer J, Darcq E, Kieffer BL, Maitra R. Discovery of a Potent, Selective, and Brain-Penetrant Small-Molecule that Activates the Orphan Receptor GPR88 and Reduces Alcohol Intake. Journal of Medicinal Chemistry. PMID 30011199 DOI: 10.1021/acs.jmedchem.8b00566  0.96
2018 Darcq E, Kieffer BL. The Control of Reward Seeking. Biological Psychiatry. 83: 981-983. PMID 29804588 DOI: 10.1016/j.biopsych.2018.04.003  0.96
2018 Schmeichel BE, Matzeu A, Koebel P, Vendruscolo LF, Sidhu H, Shahryari R, Kieffer BL, Koob GF, Martin-Fardon R, Contet C. Knockdown of hypocretin attenuates extended access of cocaine self-administration in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 29703996 DOI: 10.1038/s41386-018-0054-4  0.84
2018 Belzeaux R, Lalanne L, Kieffer BL, Lutz PE. Focusing on the Opioid System for Addiction Biomarker Discovery. Trends in Molecular Medicine. PMID 29396147 DOI: 10.1016/j.molmed.2017.12.004  1
2017 Ehrlich AT, Semache M, Bailly J, Wojcik S, Arefin TM, Colley C, Le Gouill C, Gross F, Lukasheva V, Hogue M, Darcq E, Harsan LA, Bouvier M, Kieffer BL. Mapping GPR88-Venus illuminates a novel role for GPR88 in sensory processing. Brain Structure & Function. PMID 29110094 DOI: 10.1007/s00429-017-1547-3  0.96
2017 Yoo JH, Borsodi A, Tóth G, Benyhe S, Gaspar R, Matifas A, Kieffer BL, Metaxas A, Kitchen I, Bailey A. Characterization of [(3)H] oxymorphone binding sites in mouse brain: quantitative autoradiography in opioid receptor knockout mice. Neuroscience Letters. PMID 28192197 DOI: 10.1016/j.neulet.2017.02.002  0.84
2016 Charbogne P, Gardon O, Martín-García E, Keyworth HL, Matsui A, Mechling AE, Bienert T, Nasseef T, Robé A, Moquin L, Darcq E, Ben Hamida S, Robledo P, Matifas A, Befort K, ... ... Kieffer BL, et al. Mu Opioid Receptors in Gamma-Aminobutyric Acidergic Forebrain Neurons Moderate Motivation for Heroin and Palatable Food. Biological Psychiatry. PMID 28185645 DOI: 10.1016/j.biopsych.2016.12.022  0.96
2016 Moore K, Madularu D, Iriah S, Yee JR, Kulkarni P, Darcq E, Kieffer BL, Ferris CF. BOLD Imaging in Awake Wild-Type and Mu-Opioid Receptor Knock-Out Mice Reveals On-Target Activation Maps in Response to Oxycodone. Frontiers in Neuroscience. 10: 471. PMID 27857679 DOI: 10.3389/fnins.2016.00471  0.96
2016 Becker JA, Kieffer BL, Le Merrer J. Differential behavioral and molecular alterations upon protracted abstinence from cocaine versus morphine, nicotine, THC and alcohol. Addiction Biology. PMID 27126842 DOI: 10.1111/adb.12405  0.52
2016 Mambretti EM, Kistner K, Mayer S, Massotte D, Kieffer BL, Hoffmann C, Reeh PW, Brack A, Asan E, Rittner HL. Functional and structural characterization of axonal opioid receptors as targets for analgesia. Molecular Pain. 12. PMID 27030709 DOI: 10.1177/1744806916628734  0.44
2016 Pradhan AA, Perroy J, Walwyn WM, Smith ML, Vicente-Sanchez A, Segura L, Bana A, Kieffer BL, Evans CJ. Agonist-Specific Recruitment of Arrestin Isoforms Differentially Modify Delta Opioid Receptor Function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 3541-51. PMID 27013682 DOI: 10.1523/JNEUROSCI.4124-15.2016  1
2016 Lalanne L, Ayranci G, Filliol D, Gavériaux-Ruff C, Befort K, Kieffer BL, Lutz PE. Kappa opioid receptor antagonism and chronic antidepressant treatment have beneficial activities on social interactions and grooming deficits during heroin abstinence. Addiction Biology. PMID 27001273 DOI: 10.1111/adb.12392  1
2016 Massart R, Mignon V, Stanic J, Munoz-Tello P, Becker JA, Kieffer BL, Darmon M, Sokoloff P, Diaz J. Developmental and adult expression patterns of the G protein-coupled receptor GPR88 in the rat: Establishment of a dual nuclear-cytoplasmic localization. The Journal of Comparative Neurology. PMID 26918661 DOI: 10.1002/cne.23991  1
2015 Lalanne L, Lutz PE, Trojak B, Lang JP, Kieffer BL, Bacon E. Medications between psychiatric and addictive disorders. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 65: 215-223. PMID 26514592 DOI: 10.1016/j.pnpbp.2015.10.009  1
2015 Erbs E, Faget L, Ceredig RA, Matifas A, Vonesch JL, Kieffer BL, Massotte D. Impact of chronic morphine on delta opioid receptor expressing neurons in the mouse hippocampus. Neuroscience. PMID 26480813 DOI: 10.1016/j.neuroscience.2015.10.022  1
2015 Georgiou P, Zanos P, Garcia-Carmona JA, Hourani S, Kitchen I, Kieffer BL, Laorden ML, Bailey A. The oxytocin analogue carbetocin prevents priming-induced reinstatement of morphine-seeking: Involvement of dopaminergic, noradrenergic and MOPr systems. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. PMID 26475574 DOI: 10.1016/j.euroneuro.2015.09.015  1
2015 Lonergan M, Saumier D, Tremblay J, Kieffer B, Brown TG, Brunet A. Reactivating addiction-related memories under propranolol to reduce craving: A pilot randomized controlled trial. Journal of Behavior Therapy and Experimental Psychiatry. 50: 245-249. PMID 26454715 DOI: 10.1016/j.jbtep.2015.09.012  1
2015 Ehrich JM, Messinger DI, Knakal CR, Kuhar JR, Schattauer SS, Bruchas MR, Zweifel LS, Kieffer BL, Phillips PE, Chavkin C. Kappa Opioid Receptor-Induced Aversion Requires p38 MAPK Activation in VTA Dopamine Neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 12917-31. PMID 26377476 DOI: 10.1523/JNEUROSCI.2444-15.2015  1
2015 Park MK, Kieffer B, Roberts AJ, Siggins GR, Moore SD. Interaction of CRF and Kappa Opioid Systems on GABAergic Neurotransmission in the Mouse Central Amygdala. The Journal of Pharmacology and Experimental Therapeutics. PMID 26350161 DOI: 10.1124/jpet.115.225870  1
2015 Ozawa A, Brunori G, Mercatelli D, Wu J, Cippitelli A, Zou B, Xie XS, Williams M, Zaveri NT, Low S, Scherrer G, Kieffer BL, Toll L. Knock-In Mice with NOP-eGFP Receptors Identify Receptor Cellular and Regional Localization. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 11682-93. PMID 26290245 DOI: 10.1523/JNEUROSCI.5122-14.2015  1
2015 Meirsman AC, Le Merrer J, Pellissier LP, Diaz J, Clesse D, Kieffer BL, Becker JA. Mice Lacking GPR88 Show Motor Deficit, Improved Spatial Learning, and Low Anxiety Reversed by Delta Opioid Antagonist. Biological Psychiatry. PMID 26188600 DOI: 10.1016/j.biopsych.2015.05.020  1
2015 Darcq E, Kieffer BL. PI3K signaling in the locus coeruleus: a new molecular pathway for ADHD research. Embo Molecular Medicine. 7: 859-61. PMID 25925427 DOI: 10.15252/emmm.201505266  0.96
2015 Ayranci G, Befort K, Lalanne L, Kieffer BL, Lutz PE. Dissociation of heroin-induced emotional dysfunction from psychomotor activation and physical dependence among inbred mouse strains. Psychopharmacology. 232: 1957-71. PMID 25482274 DOI: 10.1007/s00213-014-3826-5  1
2015 Chung PC, Boehrer A, Stephan A, Matifas A, Scherrer G, Darcq E, Befort K, Kieffer BL. Delta opioid receptors expressed in forebrain GABAergic neurons are responsible for SNC80-induced seizures. Behavioural Brain Research. 278: 429-34. PMID 25447299 DOI: 10.1016/j.bbr.2014.10.029  1
2015 Chu Sin Chung P, Keyworth HL, Martin-Garcia E, Charbogne P, Darcq E, Bailey A, Filliol D, Matifas A, Scherrer G, Ouagazzal AM, Gaveriaux-Ruff C, Befort K, Maldonado R, Kitchen I, Kieffer BL. A novel anxiogenic role for the delta opioid receptor expressed in GABAergic forebrain neurons. Biological Psychiatry. 77: 404-15. PMID 25444168 DOI: 10.1016/j.biopsych.2014.07.033  1
2015 Megat S, Bohren Y, Doridot S, Gaveriaux-Ruff C, Kieffer BL, Freund-Mercier MJ, Yalcin I, Barrot M. κ-Opioid receptors are not necessary for the antidepressant treatment of neuropathic pain. British Journal of Pharmacology. 172: 1034-44. PMID 25297905 DOI: 10.1111/bph.12963  1
2015 Erbs E, Faget L, Scherrer G, Matifas A, Filliol D, Vonesch JL, Koch M, Kessler P, Hentsch D, Birling MC, Koutsourakis M, Vasseur L, Veinante P, Kieffer BL, Massotte D. A mu-delta opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks. Brain Structure & Function. 220: 677-702. PMID 24623156 DOI: 10.1007/s00429-014-0717-9  1
2015 Darcq E, Kieffer BL. PI3K signaling in the locus coeruleus: A new molecular pathway for ADHD research Embo Molecular Medicine. 7: 859-861. DOI: 10.15252/emmm.201505266  1
2014 Bardoni R, Tawfik VL, Wang D, François A, Solorzano C, Shuster SA, Choudhury P, Betelli C, Cassidy C, Smith K, de Nooij JC, Mennicken F, O'Donnell D, Kieffer BL, Woodbury CJ, et al. Delta Opioid Receptors Presynaptically Regulate Cutaneous Mechanosensory Neuron Input to the Spinal Cord Dorsal Horn. Neuron. 81: 1443. PMID 28898633 DOI: 10.1016/j.neuron.2014.03.006  0.88
2014 Erbs E, Faget L, Veinante P, Kieffer BL, Massotte D. In vivo neuronal co-expression of mu and delta opioid receptors uncovers new therapeutic perspectives. Receptors & Clinical Investigation. 1. PMID 25938125 DOI: 10.14800/rci.210  0.44
2014 Lalanne L, Ayranci G, Kieffer BL, Lutz PE. The kappa opioid receptor: from addiction to depression, and back. Frontiers in Psychiatry. 5: 170. PMID 25538632 DOI: 10.3389/fpsyt.2014.00170  1
2014 Grieder TE, Herman MA, Contet C, Tan LA, Vargas-Perez H, Cohen A, Chwalek M, Maal-Bared G, Freiling J, Schlosburg JE, Clarke L, Crawford E, Koebel P, Repunte-Canonigo V, Sanna PP, ... ... Kieffer BL, et al. VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation. Nature Neuroscience. 17: 1751-8. PMID 25402857 DOI: 10.1038/nn.3872  1
2014 Gardon O, Faget L, Chu Sin Chung P, Matifas A, Massotte D, Kieffer BL. Expression of mu opioid receptor in dorsal diencephalic conduction system: new insights for the medial habenula. Neuroscience. 277: 595-609. PMID 25086313 DOI: 10.1016/j.neuroscience.2014.07.053  1
2014 Nozaki C, Nagase H, Nemoto T, Matifas A, Kieffer BL, Gaveriaux-Ruff C. In vivo properties of KNT-127, a novel δ opioid receptor agonist: receptor internalization, antihyperalgesia and antidepressant effects in mice. British Journal of Pharmacology. 171: 5376-86. PMID 25048778 DOI: 10.1111/bph.12852  1
2014 Vergnano AM, Rebola N, Savtchenko LP, Pinheiro PS, Casado M, Kieffer BL, Rusakov DA, Mulle C, Paoletti P. Zinc dynamics and action at excitatory synapses. Neuron. 82: 1101-14. PMID 24908489 DOI: 10.1016/j.neuron.2014.04.034  1
2014 Lutz PE, Ayranci G, Chu-Sin-Chung P, Matifas A, Koebel P, Filliol D, Befort K, Ouagazzal AM, Kieffer BL. Distinct mu, delta, and kappa opioid receptor mechanisms underlie low sociability and depressive-like behaviors during heroin abstinence. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 2694-705. PMID 24874714 DOI: 10.1038/npp.2014.126  1
2014 Cohen A, Whitfield TW, Kreifeldt M, Koebel P, Kieffer BL, Contet C, George O, Koob GF. Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization. Plos One. 9: e97216. PMID 24816773 DOI: 10.1371/journal.pone.0097216  1
2014 Reiss D, Walter O, Bourgoin L, Kieffer BL, Ouagazzal AM. New automated procedure to assess context recognition memory in mice. Psychopharmacology. 231: 4337-47. PMID 24770677 DOI: 10.1007/s00213-014-3577-3  1
2014 Yoo JH, Bailey A, Borsodi A, Tóth G, Matifas A, Kieffer BL, Kitchen I. Knockout subtraction autoradiography: a novel ex vivo method to detect heteromers finds sparse KOP receptor/DOP receptor heterodimerization in the brain. European Journal of Pharmacology. 731: 1-7. PMID 24657279 DOI: 10.1016/j.ejphar.2014.03.007  1
2014 Becker JA, Clesse D, Spiegelhalter C, Schwab Y, Le Merrer J, Kieffer BL. Autistic-like syndrome in mu opioid receptor null mice is relieved by facilitated mGluR4 activity. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 2049-60. PMID 24619243 DOI: 10.1038/npp.2014.59  1
2014 Bardoni R, Tawfik VL, Wang D, François A, Solorzano C, Shuster SA, Choudhury P, Betelli C, Cassidy C, Smith K, de Nooij JC, Mennicken F, O'Donnell D, Kieffer BL, Woodbury CJ, et al. Delta opioid receptors presynaptically regulate cutaneous mechanosensory neuron input to the spinal cord dorsal horn. Neuron. 81: 1312-27. PMID 24583022 DOI: 10.1016/j.neuron.2014.01.044  1
2014 Cui Y, Ostlund SB, James AS, Park CS, Ge W, Roberts KW, Mittal N, Murphy NP, Cepeda C, Kieffer BL, Levine MS, Jentsch JD, Walwyn WM, Sun YE, Evans CJ, et al. Targeted expression of μ-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward. Nature Neuroscience. 17: 254-61. PMID 24413699 DOI: 10.1038/nn.3622  1
2014 Charbogne P, Kieffer BL, Befort K. 15 years of genetic approaches in vivo for addiction research: Opioid receptor and peptide gene knockout in mouse models of drug abuse. Neuropharmacology. 76: 204-17. PMID 24035914 DOI: 10.1016/j.neuropharm.2013.08.028  1
2014 Contet C, Kim A, Le D, Iyengar SK, Kotzebue RW, Yuan CJ, Kieffer BL, Mandyam CD. μ-Opioid receptors mediate the effects of chronic ethanol binge drinking on the hippocampal neurogenic niche. Addiction Biology. 19: 770-80. PMID 23461397 DOI: 10.1111/adb.12040  1
2014 Bardoni R, Tawfik VL, Wang D, François A, Solorzano C, Shuster SA, Choudhury P, Betelli C, Cassidy C, Smith K, deNooij JC, Mennicken F, O'Donnell D, Kieffer BL, Woodbury CJ, et al. Delta opioid receptors presynaptically regulate cutaneous mechanosensory neuron input to the spinal cord dorsal horn Neuron. 81: 1443. DOI: 10.1016/j.neuron.2014.03.006  1
2013 Rezai X, Kieffer BL, Roux MJ, Massotte D. Delta opioid receptors regulate temporoammonic-activated feedforward inhibition to the mouse CA1 hippocampus. Plos One. 8: e79081. PMID 24260157 DOI: 10.1371/journal.pone.0079081  1
2013 Weibel R, Reiss D, Karchewski L, Gardon O, Matifas A, Filliol D, Becker JA, Wood JN, Kieffer BL, Gaveriaux-Ruff C. Mu opioid receptors on primary afferent nav1.8 neurons contribute to opiate-induced analgesia: insight from conditional knockout mice. Plos One. 8: e74706. PMID 24069332 DOI: 10.1371/journal.pone.0074706  1
2013 Chu Sin Chung P, Kieffer BL. Delta opioid receptors in brain function and diseases. Pharmacology & Therapeutics. 140: 112-20. PMID 23764370 DOI: 10.1016/j.pharmthera.2013.06.003  1
2013 Erbs E, Pradhan AA, Matifas A, Kieffer BL, Massotte D. Evaluation of cre recombinase delivery in mammalian cells using baculovirus infection. Journal of Biotechnology. 166: 182-6. PMID 23732834 DOI: 10.1016/j.jbiotec.2013.05.011  1
2013 Kang-Park M, Kieffer BL, Roberts AJ, Siggins GR, Moore SD. κ-Opioid receptors in the central amygdala regulate ethanol actions at presynaptic GABAergic sites. The Journal of Pharmacology and Experimental Therapeutics. 346: 130-7. PMID 23587526 DOI: 10.1124/jpet.112.202903  1
2013 Lutz PE, Kieffer BL. The multiple facets of opioid receptor function: implications for addiction. Current Opinion in Neurobiology. 23: 473-9. PMID 23453713 DOI: 10.1016/j.conb.2013.02.005  1
2013 Le Merrer J, Rezai X, Scherrer G, Becker JA, Kieffer BL. Impaired hippocampus-dependent and facilitated striatum-dependent behaviors in mice lacking the δ opioid receptor. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 1050-9. PMID 23303070 DOI: 10.1038/npp.2013.1  1
2013 Lutz PE, Reiss D, Ouagazzal AM, Kieffer BL. A history of chronic morphine exposure during adolescence increases despair-like behaviour and strain-dependently promotes sociability in abstinent adult mice. Behavioural Brain Research. 243: 44-52. PMID 23295400 DOI: 10.1016/j.bbr.2012.12.049  1
2013 Lutz PE, Kieffer BL. Opioid receptors: distinct roles in mood disorders. Trends in Neurosciences. 36: 195-206. PMID 23219016 DOI: 10.1016/j.tins.2012.11.002  1
2012 Baldock PA, Driessler F, Lin S, Wong IP, Shi Y, Yulyaningsih E, Castillo L, Janmaat S, Enriquez RF, Zengin A, Kieffer BL, Schwarzer C, Eisman JA, Sainsbury A, Herzog H. The endogenous opioid dynorphin is required for normal bone homeostasis in mice. Neuropeptides. 46: 383-94. PMID 23062312 DOI: 10.1016/j.npep.2012.08.010  1
2012 Reiss D, Prinssen EP, Wichmann J, Kieffer BL, Ouagazzal AM. The nociceptin orphanin FQ peptide receptor agonist, Ro64-6198, impairs recognition memory formation through interaction with glutamatergic but not cholinergic receptor antagonists. Neurobiology of Learning and Memory. 98: 254-60. PMID 22982481 DOI: 10.1016/j.nlm.2012.09.002  1
2012 Erbs E, Faget L, Scherrer G, Kessler P, Hentsch D, Vonesch JL, Matifas A, Kieffer BL, Massotte D. Distribution of delta opioid receptor-expressing neurons in the mouse hippocampus. Neuroscience. 221: 203-13. PMID 22750239 DOI: 10.1016/j.neuroscience.2012.06.023  1
2012 Pradhan AA, Smith ML, Kieffer BL, Evans CJ. Ligand-directed signalling within the opioid receptor family. British Journal of Pharmacology. 167: 960-9. PMID 22708627 DOI: 10.1111/j.1476-5381.2012.02075.x  1
2012 Nozaki C, Le Bourdonnec B, Reiss D, Windh RT, Little PJ, Dolle RE, Kieffer BL, Gavériaux-Ruff C. δ-Opioid mechanisms for ADL5747 and ADL5859 effects in mice: analgesia, locomotion, and receptor internalization. The Journal of Pharmacology and Experimental Therapeutics. 342: 799-807. PMID 22700431 DOI: 10.1124/jpet.111.188987  1
2012 Berrendero F, Plaza-Zabala A, Galeote L, Flores Á, Bura SA, Kieffer BL, Maldonado R. Influence of δ-opioid receptors in the behavioral effects of nicotine. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 2332-44. PMID 22669166 DOI: 10.1038/npp.2012.88  1
2012 Faget L, Erbs E, Le Merrer J, Scherrer G, Matifas A, Benturquia N, Noble F, Decossas M, Koch M, Kessler P, Vonesch JL, Schwab Y, Kieffer BL, Massotte D. In vivo visualization of delta opioid receptors upon physiological activation uncovers a distinct internalization profile. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 7301-10. PMID 22623675 DOI: 10.1523/JNEUROSCI.0185-12.2012  1
2012 Del Boca C, Lutz PE, Le Merrer J, Koebel P, Kieffer BL. Cholecystokinin knock-down in the basolateral amygdala has anxiolytic and antidepressant-like effects in mice. Neuroscience. 218: 185-95. PMID 22613736 DOI: 10.1016/j.neuroscience.2012.05.022  1
2012 Nguyen AT, Marquez P, Hamid A, Kieffer B, Friedman TC, Lutfy K. The rewarding action of acute cocaine is reduced in β-endorphin deficient but not in μ opioid receptor knockout mice. European Journal of Pharmacology. 686: 50-4. PMID 22575525 DOI: 10.1016/j.ejphar.2012.04.040  1
2012 Le Merrer J, Faget L, Matifas A, Kieffer BL. Cues predicting drug or food reward restore morphine-induced place conditioning in mice lacking delta opioid receptors. Psychopharmacology. 223: 99-106. PMID 22526530 DOI: 10.1007/s00213-012-2693-1  1
2012 Rezaï X, Faget L, Bednarek E, Schwab Y, Kieffer BL, Massotte D. Mouse δ opioid receptors are located on presynaptic afferents to hippocampal pyramidal cells. Cellular and Molecular Neurobiology. 32: 509-16. PMID 22252784 DOI: 10.1007/s10571-011-9791-1  1
2012 Darcq E, Befort K, Koebel P, Pannetier S, Mahoney MK, Gaveriaux-Ruff C, Hanauer A, Kieffer BL. RSK2 signaling in medial habenula contributes to acute morphine analgesia. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 1288-96. PMID 22218090 DOI: 10.1038/npp.2011.316  1
2012 Le Merrer J, Befort K, Gardon O, Filliol D, Darcq E, Dembele D, Becker JA, Kieffer BL. Protracted abstinence from distinct drugs of abuse shows regulation of a common gene network. Addiction Biology. 17: 1-12. PMID 21955143 DOI: 10.1111/j.1369-1600.2011.00365.x  1
2012 Ces A, Reiss D, Walter O, Wichmann J, Prinssen EP, Kieffer BL, Ouagazzal AM. Activation of nociceptin/orphanin FQ peptide receptors disrupts visual but not auditory sensorimotor gating in BALB/cByJ mice: comparison to dopamine receptor agonists. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 378-89. PMID 21881568 DOI: 10.1038/npp.2011.175  1
2011 Karaji AG, Reiss D, Matifas A, Kieffer BL, Gavériaux-Ruff C. Influence of endogenous opioid systems on T lymphocytes as assessed by the knockout of mu, delta and kappa opioid receptors. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 6: 608-16. PMID 21938479 DOI: 10.1007/s11481-011-9314-3  1
2011 Pradhan AA, Befort K, Nozaki C, Gavériaux-Ruff C, Kieffer BL. The delta opioid receptor: an evolving target for the treatment of brain disorders. Trends in Pharmacological Sciences. 32: 581-90. PMID 21925742 DOI: 10.1016/j.tips.2011.06.008  1
2011 Darcq E, Koebel P, Del Boca C, Pannetier S, Kirstetter AS, Garnier JM, Hanauer A, Befort K, Kieffer BL. RSK2 signaling in brain habenula contributes to place aversion learning. Learning & Memory (Cold Spring Harbor, N.Y.). 18: 574-8. PMID 21852432 DOI: 10.1101/lm.2221011  1
2011 Gavériaux-Ruff C, Kieffer BL. Delta opioid receptor analgesia: recent contributions from pharmacology and molecular approaches. Behavioural Pharmacology. 22: 405-14. PMID 21836459 DOI: 10.1097/FBP.0b013e32834a1f2c  1
2011 Nozaki C, Vergnano AM, Filliol D, Ouagazzal AM, Le Goff A, Carvalho S, Reiss D, Gaveriaux-Ruff C, Neyton J, Paoletti P, Kieffer BL. Zinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunit. Nature Neuroscience. 14: 1017-22. PMID 21725314 DOI: 10.1038/nn.2844  1
2011 Poole DP, Pelayo JC, Scherrer G, Evans CJ, Kieffer BL, Bunnett NW. Localization and regulation of fluorescently labeled delta opioid receptor, expressed in enteric neurons of mice. Gastroenterology. 141: 982-991.e1-8. PMID 21699782 DOI: 10.1053/j.gastro.2011.05.042  1
2011 Lutz PE, Pradhan AA, Goeldner C, Kieffer BL. Sequential and opposing alterations of 5-HT(1A) receptor function during withdrawal from chronic morphine. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 21: 835-40. PMID 21402471 DOI: 10.1016/j.euroneuro.2011.02.002  1
2011 Contet C, Gardon O, Filliol D, Becker JA, Koob GF, Kieffer BL. Identification of genes regulated in the mouse extended amygdala by excessive ethanol drinking associated with dependence. Addiction Biology. 16: 615-9. PMID 21392173 DOI: 10.1111/j.1369-1600.2010.00304.x  1
2011 Gaveriaux-Ruff C, Nozaki C, Nadal X, Hever XC, Weibel R, Matifas A, Reiss D, Filliol D, Nassar MA, Wood JN, Maldonado R, Kieffer BL. Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesia. Pain. 152: 1238-48. PMID 21295407 DOI: 10.1016/j.pain.2010.12.031  1
2011 Befort K, Mahoney MK, Chow C, Hayton SJ, Kieffer BL, Olmstead MC. Effects of delta opioid receptors activation on a response inhibition task in rats. Psychopharmacology. 214: 967-76. PMID 21181131 DOI: 10.1007/s00213-010-2108-0  1
2011 Le Merrer J, Plaza-Zabala A, Del Boca C, Matifas A, Maldonado R, Kieffer BL. Deletion of the δ opioid receptor gene impairs place conditioning but preserves morphine reinforcement. Biological Psychiatry. 69: 700-3. PMID 21168121 DOI: 10.1016/j.biopsych.2010.10.021  1
2011 Goeldner C, Lutz PE, Darcq E, Halter T, Clesse D, Ouagazzal AM, Kieffer BL. Impaired emotional-like behavior and serotonergic function during protracted abstinence from chronic morphine. Biological Psychiatry. 69: 236-44. PMID 20947067 DOI: 10.1016/j.biopsych.2010.08.021  1
2011 Scherrer G, Kieffer BL. A new approach to visualize endogenously expressed G protein-coupled receptors in tissues and living cells Neuromethods. 60: 105-131. DOI: 10.1007/978-1-61779-179-6_6  1
2010 Pradhan AA, Walwyn W, Nozaki C, Filliol D, Erbs E, Matifas A, Evans C, Kieffer BL. Ligand-directed trafficking of the δ-opioid receptor in vivo: two paths toward analgesic tolerance. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 16459-68. PMID 21147985 DOI: 10.1523/JNEUROSCI.3748-10.2010  1
2010 Yoo JH, Bailey A, Ansonoff M, Pintar JE, Matifas A, Kieffer BL, Kitchen I. Lack of genotype effect on D1, D2 receptors and dopamine transporter binding in triple MOP-, DOP-, and KOP-opioid receptor knockout mice of three different genetic backgrounds. Synapse (New York, N.Y.). 64: 520-7. PMID 20196137 DOI: 10.1002/syn.20757  1
2010 Goeldner C, Reiss D, Kieffer BL, Ouagazzal AM. Endogenous nociceptin/orphanin-FQ in the dorsal hippocampus facilitates despair-related behavior. Hippocampus. 20: 911-6. PMID 20087887 DOI: 10.1002/hipo.20760  1
2010 Bohren Y, Karavelic D, Tessier LH, Yalcin I, Gavériaux-Ruff C, Kieffer BL, Freund-Mercier MJ, Barrot M. Mu-opioid receptors are not necessary for nortriptyline treatment of neuropathic allodynia. European Journal of Pain (London, England). 14: 700-4. PMID 20056557 DOI: 10.1016/j.ejpain.2009.11.014  1
2010 Kieffer BL. Opioid Peptides and Receptors Encyclopedia of Neuroscience. 235-240. DOI: 10.1016/B978-008045046-9.01472-8  1
2009 Le Merrer J, Becker JA, Befort K, Kieffer BL. Reward processing by the opioid system in the brain. Physiological Reviews. 89: 1379-412. PMID 19789384 DOI: 10.1152/physrev.00005.2009  1
2009 Scherrer G, Imamachi N, Cao YQ, Contet C, Mennicken F, O'Donnell D, Kieffer BL, Basbaum AI. Dissociation of the opioid receptor mechanisms that control mechanical and heat pain. Cell. 137: 1148-59. PMID 19524516 DOI: 10.1016/j.cell.2009.04.019  1
2009 Pradhan AA, Becker JA, Scherrer G, Tryoen-Toth P, Filliol D, Matifas A, Massotte D, Gavériaux-Ruff C, Kieffer BL. In vivo delta opioid receptor internalization controls behavioral effects of agonists. Plos One. 4: e5425. PMID 19412545 DOI: 10.1371/journal.pone.0005425  1
2009 Olmstead MC, Ouagazzal AM, Kieffer BL. Mu and delta opioid receptors oppositely regulate motor impulsivity in the signaled nose poke task. Plos One. 4: e4410. PMID 19198656 DOI: 10.1371/journal.pone.0004410  1
2009 Goeldner C, Reiss D, Wichmann J, Kieffer BL, Ouagazzal AM. Activation of nociceptin opioid peptide (NOP) receptor impairs contextual fear learning in mice through glutamatergic mechanisms. Neurobiology of Learning and Memory. 91: 393-401. PMID 19100850 DOI: 10.1016/j.nlm.2008.12.001  1
2009 Kang-Park MH, Kieffer BL, Roberts AJ, Roberto M, Madamba SG, Siggins GR, Moore SD. Mu-opioid receptors selectively regulate basal inhibitory transmission in the central amygdala: lack of ethanol interactions. The Journal of Pharmacology and Experimental Therapeutics. 328: 284-93. PMID 18854491 DOI: 10.1124/jpet.108.140749  1
2009 Kieffer BL, Evans CJ. Opioid receptors: from binding sites to visible molecules in vivo. Neuropharmacology. 56: 205-12. PMID 18718480 DOI: 10.1016/j.neuropharm.2008.07.033  1
2009 Kieffer BL. Live molecular recognition: Visualizing opioid receptors trafficking in vivo Journal of Inclusion Phenomena and Macrocyclic Chemistry. 65: 189-195. DOI: 10.1007/s10847-009-9637-3  1
2008 Becker JA, Befort K, Blad C, Filliol D, Ghate A, Dembele D, Thibault C, Koch M, Muller J, Lardenois A, Poch O, Kieffer BL. Transcriptome analysis identifies genes with enriched expression in the mouse central extended amygdala. Neuroscience. 156: 950-65. PMID 18786617 DOI: 10.1016/j.neuroscience.2008.07.070  1
2008 Befort K, Filliol D, Darcq E, Ghate A, Matifas A, Lardenois A, Muller J, Thibault C, Dembele D, Poch O, Kieffer BL. Gene expression is altered in the lateral hypothalamus upon activation of the mu opioid receptor. Annals of the New York Academy of Sciences. 1129: 175-84. PMID 18591478 DOI: 10.1196/annals.1417.028  1
2008 Befort K, Filliol D, Ghate A, Darcq E, Matifas A, Muller J, Lardenois A, Thibault C, Dembele D, Le Merrer J, Becker JA, Poch O, Kieffer BL. Mu-opioid receptor activation induces transcriptional plasticity in the central extended amygdala. The European Journal of Neuroscience. 27: 2973-84. PMID 18588537 DOI: 10.1111/j.1460-9568.2008.06273.x  1
2008 Gavériaux-Ruff C, Karchewski LA, Hever X, Matifas A, Kieffer BL. Inflammatory pain is enhanced in delta opioid receptor-knockout mice. The European Journal of Neuroscience. 27: 2558-67. PMID 18513322 DOI: 10.1111/j.1460-9568.2008.06223.x  1
2008 Goeldner C, Reiss D, Wichmann J, Meziane H, Kieffer BL, Ouagazzal AM. Nociceptin receptor impairs recognition memory via interaction with NMDA receptor-dependent mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in the hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 2190-8. PMID 18305252 DOI: 10.1523/JNEUROSCI.3711-07.2008  1
2008 Snook LA, Milligan G, Kieffer BL, Massotte D. Co-expression of mu and delta opioid receptors as receptor-G protein fusions enhances both mu and delta signalling via distinct mechanisms. Journal of Neurochemistry. 105: 865-73. PMID 18182056 DOI: 10.1111/j.1471-4159.2008.05215.x  1
2008 Contet C, Filliol D, Matifas A, Kieffer BL. Morphine-induced analgesic tolerance, locomotor sensitization and physical dependence do not require modification of mu opioid receptor, cdk5 and adenylate cyclase activity. Neuropharmacology. 54: 475-86. PMID 18082850 DOI: 10.1016/j.neuropharm.2007.10.015  1
2008 Reiss D, Wichmann J, Tekeshima H, Kieffer BL, Ouagazzal AM. Effects of nociceptin/orphanin FQ receptor (NOP) agonist, Ro64-6198, on reactivity to acute pain in mice: comparison to morphine. European Journal of Pharmacology. 579: 141-8. PMID 18031727 DOI: 10.1016/j.ejphar.2007.10.031  1
2008 David V, Matifas A, Gavello-Baudy S, Decorte L, Kieffer BL, Cazala P. Brain regional Fos expression elicited by the activation of mu- but not delta-opioid receptors of the ventral tegmental area: evidence for an implication of the ventral thalamus in opiate reward. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 1746-59. PMID 17895918 DOI: 10.1038/sj.npp.1301529  1
2008 Benbouzid M, Gavériaux-Ruff C, Yalcin I, Waltisperger E, Tessier LH, Muller A, Kieffer BL, Freund-Mercier MJ, Barrot M. Delta-opioid receptors are critical for tricyclic antidepressant treatment of neuropathic allodynia. Biological Psychiatry. 63: 633-6. PMID 17693391 DOI: 10.1016/j.biopsych.2007.06.016  1
2007 Papaleo F, Kieffer BL, Tabarin A, Contarino A. Decreased motivation to eat in mu-opioid receptor-deficient mice. The European Journal of Neuroscience. 25: 3398-405. PMID 17553008 DOI: 10.1111/j.1460-9568.2007.05595.x  1
2007 Ghate A, Befort K, Becker JA, Filliol D, Bole-Feysot C, Demebele D, Jost B, Koch M, Kieffer BL. Identification of novel striatal genes by expression profiling in adult mouse brain. Neuroscience. 146: 1182-92. PMID 17395390 DOI: 10.1016/j.neuroscience.2007.02.040  1
2007 Marquez P, Baliram R, Kieffer BL, Lutfy K. The mu opioid receptor is involved in buprenorphine-induced locomotor stimulation and conditioned place preference. Neuropharmacology. 52: 1336-41. PMID 17367825 DOI: 10.1016/j.neuropharm.2007.01.005  1
2007 Chakass D, Philippe D, Erdual E, Dharancy S, Malapel M, Dubuquoy C, Thuru X, Gay J, Gaveriaux-Ruff C, Dubus P, Mathurin P, Kieffer BL, Desreumaux P, Chamaillard M. micro-Opioid receptor activation prevents acute hepatic inflammation and cell death. Gut. 56: 974-81. PMID 17299060 DOI: 10.1136/gut.2006.105122  1
2007 Gavériaux-Ruff C, Kieffer BL. Conditional gene targeting in the mouse nervous system: Insights into brain function and diseases. Pharmacology & Therapeutics. 113: 619-34. PMID 17289150 DOI: 10.1016/j.pharmthera.2006.12.003  1
2007 Contet C, Dierich A, Kieffer BL. Knock-in mice reveal nonsense-mediated mRNA decay in the brain. Genesis (New York, N.Y. : 2000). 45: 38-43. PMID 17216605 DOI: 10.1002/dvg.20263  1
2007 Nagai J, Kurokawa M, Takeshima H, Kieffer BL, Ueda H. Circadian-dependent learning and memory enhancement in nociceptin receptor-deficient mice with a novel KUROBOX apparatus using stress-free positive cue task. The Journal of Pharmacology and Experimental Therapeutics. 321: 195-201. PMID 17209168 DOI: 10.1124/jpet.106.115121  1
2007 Bigliardi-Qi M, Gaveriaux-Ruff C, Pfaltz K, Bady P, Baumann T, Rufli T, Kieffer BL, Bigliardi PL. Deletion of mu- and kappa-opioid receptors in mice changes epidermal hypertrophy, density of peripheral nerve endings, and itch behavior. The Journal of Investigative Dermatology. 127: 1479-88. PMID 17185983 DOI: 10.1038/sj.jid.5700661  1
2007 Kang-Park MH, Kieffer BL, Roberts AJ, Siggins GR, Moore SD. Presynaptic delta opioid receptors regulate ethanol actions in central amygdala. The Journal of Pharmacology and Experimental Therapeutics. 320: 917-25. PMID 17114568 DOI: 10.1124/jpet.106.112722  1
2007 García-Fuster MJ, Ferrer-Alcón M, Martín M, Kieffer BL, Maldonado R, García-Sevilla JA. Effects of constitutive deletion of opioid receptors on the basal densities of Fas and Fas-associated protein with death domain (FADD) in the mouse brain: a delta-opioid tone inhibits FADD. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 17: 366-74. PMID 17030115 DOI: 10.1016/j.euroneuro.2006.08.008  1
2007 Kieffer BL. How does the opioid system control pain, reward and behavior additives? | In quale modo il sistema oppioide controlla dolore, reward e comportamenti additivi? Giornale Di Neuropsicofarmacologia. 29: 102-104.  1
2006 Walwyn WM, Wei W, Xie CW, Chiu K, Kieffer BL, Evans CJ, Maidment NT. Mu opioid receptor-effector coupling and trafficking in dorsal root ganglia neurons. Neuroscience. 142: 493-503. PMID 16887280 DOI: 10.1016/j.neuroscience.2006.06.021  1
2006 Scherrer G, Tryoen-Tóth P, Filliol D, Matifas A, Laustriat D, Cao YQ, Basbaum AI, Dierich A, Vonesh JL, Gavériaux-Ruff C, Kieffer BL. Knockin mice expressing fluorescent delta-opioid receptors uncover G protein-coupled receptor dynamics in vivo. Proceedings of the National Academy of Sciences of the United States of America. 103: 9691-6. PMID 16766653 DOI: 10.1073/pnas.0603359103  1
2006 Snook LA, Milligan G, Kieffer BL, Massotte D. Mu-delta opioid receptor functional interaction: Insight using receptor-G protein fusions. The Journal of Pharmacology and Experimental Therapeutics. 318: 683-90. PMID 16690720 DOI: 10.1124/jpet.106.101220  1
2006 Galeote L, Kieffer BL, Maldonado R, Berrendero F. Mu-opioid receptors are involved in the tolerance to nicotine antinociception. Journal of Neurochemistry. 97: 416-23. PMID 16539669 DOI: 10.1111/j.1471-4159.2006.03751.x  1
2006 Merg F, Filliol D, Usynin I, Bazov I, Bark N, Hurd YL, Yakovleva T, Kieffer BL, Bakalkin G. Big dynorphin as a putative endogenous ligand for the kappa-opioid receptor. Journal of Neurochemistry. 97: 292-301. PMID 16515546 DOI: 10.1111/j.1471-4159.2006.03732.x  1
2006 Nadal X, Baños JE, Kieffer BL, Maldonado R. Neuropathic pain is enhanced in delta-opioid receptor knockout mice. The European Journal of Neuroscience. 23: 830-4. PMID 16487163 DOI: 10.1111/j.1460-9568.2006.04569.x  1
2006 Simonin F, Schmitt M, Laulin JP, Laboureyras E, Jhamandas JH, MacTavish D, Matifas A, Mollereau C, Laurent P, Parmentier M, Kieffer BL, Bourguignon JJ, Simonnet G. RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia. Proceedings of the National Academy of Sciences of the United States of America. 103: 466-71. PMID 16407169 DOI: 10.1073/pnas.0502090103  1
2006 Contet C, Gavériaux-Ruff C, Matifas A, Caradec C, Champy MF, Kieffer BL. Dissociation of analgesic and hormonal responses to forced swim stress using opioid receptor knockout mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 1733-44. PMID 16237385 DOI: 10.1038/sj.npp.1300934  1
2005 Tabarin A, Diz-Chaves Y, Chaves YD, Carmona Mdel C, Catargi B, Zorrilla EP, Roberts AJ, Coscina DV, Rousset S, Redonnet A, Parker GC, Inoue K, Ricquier D, Pénicaud L, Kieffer BL, et al. Resistance to diet-induced obesity in mu-opioid receptor-deficient mice: evidence for a "thrifty gene". Diabetes. 54: 3510-6. PMID 16306369 DOI: 10.2337/diabetes.54.12.3510  1
2005 Walwyn W, Maidment NT, Sanders M, Evans CJ, Kieffer BL, Hales TG. Induction of delta opioid receptor function by up-regulation of membrane receptors in mouse primary afferent neurons. Molecular Pharmacology. 68: 1688-98. PMID 16135785 DOI: 10.1124/mol.105.014829  1
2005 Nieto MM, Guen SL, Kieffer BL, Roques BP, Noble F. Physiological control of emotion-related behaviors by endogenous enkephalins involves essentially the delta opioid receptors. Neuroscience. 135: 305-13. PMID 16112476 DOI: 10.1016/j.neuroscience.2005.06.025  1
2005 Ghozland S, Chu K, Kieffer BL, Roberts AJ. Lack of stimulant and anxiolytic-like effects of ethanol and accelerated development of ethanol dependence in mu-opioid receptor knockout mice. Neuropharmacology. 49: 493-501. PMID 15961126 DOI: 10.1016/j.neuropharm.2005.04.006  1
2005 Sanders MJ, Kieffer BL, Fanselow MS. Deletion of the mu opioid receptor results in impaired acquisition of Pavlovian context fear. Neurobiology of Learning and Memory. 84: 33-41. PMID 15936681 DOI: 10.1016/j.nlm.2005.03.001  1
2005 Kovacs KM, Szakall I, O'Brien D, Wang R, Vinod KY, Saito M, Simonin F, Kieffer BL, Vadasz C. Decreased oral self-administration of alcohol in kappa-opioid receptor knock-out mice. Alcoholism, Clinical and Experimental Research. 29: 730-8. PMID 15897716 DOI: 10.1097/01.ALC.0000164361.62346.D6  1
2005 Grillet N, Pattyn A, Contet C, Kieffer BL, Goridis C, Brunet JF. Generation and characterization of Rgs4 mutant mice. Molecular and Cellular Biology. 25: 4221-8. PMID 15870291 DOI: 10.1128/MCB.25.10.4221-4228.2005  1
2005 Massotte D, Kieffer BL. The second extracellular loop: a damper for G protein-coupled receptors? Nature Structural & Molecular Biology. 12: 287-8. PMID 15809647 DOI: 10.1038/nsmb0405-287  1
2005 Tryoen-Tóth P, Décaillot FM, Filliol D, Befort K, Lazarus LH, Schiller PW, Schmidhammer H, Kieffer BL. Inverse agonism and neutral antagonism at wild-type and constitutively active mutant delta opioid receptors. The Journal of Pharmacology and Experimental Therapeutics. 313: 410-21. PMID 15590769 DOI: 10.1124/jpet.104.077321  1
2004 Chefer VI, Kieffer BL, Shippenberg TS. Contrasting effects of mu opioid receptor and delta opioid receptor deletion upon the behavioral and neurochemical effects of cocaine. Neuroscience. 127: 497-503. PMID 15262338 DOI: 10.1016/j.neuroscience.2004.05.021  1
2004 Robledo P, Mendizabal V, Ortuño J, de la Torre R, Kieffer BL, Maldonado R. The rewarding properties of MDMA are preserved in mice lacking mu-opioid receptors. The European Journal of Neuroscience. 20: 853-8. PMID 15255997 DOI: 10.1111/j.1460-9568.2004.03532.x  1
2004 Moles A, Kieffer BL, D'Amato FR. Deficit in attachment behavior in mice lacking the mu-opioid receptor gene. Science (New York, N.Y.). 304: 1983-6. PMID 15218152 DOI: 10.1126/science.1095943  1
2004 Contet C, Kieffer BL, Befort K. Mu opioid receptor: a gateway to drug addiction. Current Opinion in Neurobiology. 14: 370-8. PMID 15194118 DOI: 10.1016/j.conb.2004.05.005  1
2004 Contet C, Matifas A, Kieffer BL. No evidence for G-protein-coupled epsilon receptor in the brain of triple opioid receptor knockout mouse. European Journal of Pharmacology. 492: 131-6. PMID 15178356 DOI: 10.1016/j.ejphar.2004.03.056  1
2004 Dierich A, Kieffer BL. Knockout mouse models in pain research. Methods in Molecular Medicine. 99: 269-99. PMID 15131344 DOI: 10.1385/1-59259-770-X:269  1
2004 Gouardères C, Kieffer BL, Zajac JM. Opposite alterations of NPFF1 and NPFF2 neuropeptide FF receptor density in the triple MOR/DOR/KOR-opioid receptor knockout mouse brains. Journal of Chemical Neuroanatomy. 27: 119-28. PMID 15121216 DOI: 10.1016/j.jchemneu.2004.01.002  1
2004 Scherrer G, Befort K, Contet C, Becker J, Matifas A, Kieffer BL. The delta agonists DPDPE and deltorphin II recruit predominantly mu receptors to produce thermal analgesia: a parallel study of mu, delta and combinatorial opioid receptor knockout mice. The European Journal of Neuroscience. 19: 2239-48. PMID 15090050 DOI: 10.1111/j.0953-816X.2004.03339.x  1
2004 Simonin F, Karcher P, Boeuf JJ, Matifas A, Kieffer BL. Identification of a novel family of G protein-coupled receptor associated sorting proteins. Journal of Neurochemistry. 89: 766-75. PMID 15086532 DOI: 10.1111/j.1471-4159.2004.02411.x  1
2004 García-Sevilla JA, Ferrer-Alcón M, Martín M, Kieffer BL, Maldonado R. Neurofilament proteins and cAMP pathway in brains of mu-, delta- or kappa-opioid receptor gene knock-out mice: effects of chronic morphine administration. Neuropharmacology. 46: 519-30. PMID 14975676 DOI: 10.1016/j.neuropharm.2003.10.006  1
2004 Walwyn WM, Keith DE, Wei W, Tan AM, Xie CW, Evans CJ, Kieffer BL, Maidment NT. Functional coupling, desensitization and internalization of virally expressed mu opioid receptors in cultured dorsal root ganglion neurons from mu opioid receptor knockout mice. Neuroscience. 123: 111-21. PMID 14667446 DOI: 10.1016/j.neuroscience.2003.08.060  1
2004 Wang D, Raehal KM, Lin ET, Lowery JJ, Kieffer BL, Bilsky EJ, Sadée W. Basal signaling activity of mu opioid receptor in mouse brain: role in narcotic dependence. The Journal of Pharmacology and Experimental Therapeutics. 308: 512-20. PMID 14600246 DOI: 10.1124/jpet.103.054049  1
2003 Brillet K, Kieffer BL, Massotte D. Enhanced spontaneous activity of the mu opioid receptor by cysteine mutations: characterization of a tool for inverse agonist screening. Bmc Pharmacology. 3: 14. PMID 14641935 DOI: 10.1186/1471-2210-3-14  1
2003 Romberg R, Sarton E, Teppema L, Matthes HW, Kieffer BL, Dahan A. Comparison of morphine-6-glucuronide and morphine on respiratory depressant and antinociceptive responses in wild type and mu-opioid receptor deficient mice. British Journal of Anaesthesia. 91: 862-70. PMID 14633759 DOI: 10.1093/bja/aeg279  1
2003 Chefer VI, Kieffer BL, Shippenberg TS. Basal and morphine-evoked dopaminergic neurotransmission in the nucleus accumbens of MOR- and DOR-knockout mice. The European Journal of Neuroscience. 18: 1915-22. PMID 14622224 DOI: 10.1046/j.1460-9568.2003.02912.x  1
2003 Berrendero F, Mendizábal V, Murtra P, Kieffer BL, Maldonado R. Cannabinoid receptor and WIN 55 212-2-stimulated [35S]-GTPgammaS binding in the brain of mu-, delta- and kappa-opioid receptor knockout mice. The European Journal of Neuroscience. 18: 2197-202. PMID 14622180 DOI: 10.1046/j.1460-9568.2003.02951.x  1
2003 Lutfy K, Eitan S, Bryant CD, Yang YC, Saliminejad N, Walwyn W, Kieffer BL, Takeshima H, Carroll FI, Maidment NT, Evans CJ. Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 10331-7. PMID 14614092  1
2003 Jamot L, Matthes HW, Simonin F, Kieffer BL, Roder JC. Differential involvement of the mu and kappa opioid receptors in spatial learning. Genes, Brain, and Behavior. 2: 80-92. PMID 12884965 DOI: 10.1034/j.1601-183X.2003.00013.x  1
2003 Décaillot FM, Befort K, Filliol D, Yue S, Walker P, Kieffer BL. Opioid receptor random mutagenesis reveals a mechanism for G protein-coupled receptor activation. Nature Structural Biology. 10: 629-36. PMID 12847517 DOI: 10.1038/nsb950  1
2003 Morinville A, Cahill CM, Esdaile MJ, Aibak H, Collier B, Kieffer BL, Beaudet A. Regulation of delta-opioid receptor trafficking via mu-opioid receptor stimulation: evidence from mu-opioid receptor knock-out mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 4888-98. PMID 12832511  1
2003 Philippe D, Dubuquoy L, Groux H, Brun V, Chuoï-Mariot MT, Gaveriaux-Ruff C, Colombel JF, Kieffer BL, Desreumaux P. Anti-inflammatory properties of the mu opioid receptor support its use in the treatment of colon inflammation. The Journal of Clinical Investigation. 111: 1329-38. PMID 12727924 DOI: 10.1172/JCI16750  1
2003 Oakley SM, Toth G, Borsodi A, Kieffer BL, Kitchen I. G-protein coupling of delta-opioid receptors in brains of mu-opioid receptor knockout mice. European Journal of Pharmacology. 466: 91-8. PMID 12679145 DOI: 10.1016/S0014-2999(03)01531-0  1
2003 Koob GF, Roberts AJ, Kieffer BL, Heyser CJ, Katner SN, Ciccocioppo R, Weiss F. Animal models of motivation for drinking in rodents with a focus on opioid receptor neuropharmacology. Recent Developments in Alcoholism : An Official Publication of the American Medical Society On Alcoholism, the Research Society On Alcoholism, and the National Council On Alcoholism. 16: 263-81. PMID 12638642  1
2003 Martin M, Matifas A, Maldonado R, Kieffer BL. Acute antinociceptive responses in single and combinatorial opioid receptor knockout mice: distinct mu, delta and kappa tones. The European Journal of Neuroscience. 17: 701-8. PMID 12603260 DOI: 10.1046/j.1460-9568.2003.02482.x  1
2003 Castañé A, Robledo P, Matifas A, Kieffer BL, Maldonado R. Cannabinoid withdrawal syndrome is reduced in double mu and delta opioid receptor knockout mice. The European Journal of Neuroscience. 17: 155-9. PMID 12534979 DOI: 10.1046/j.1460-9568.2003.02409.x  1
2003 Gavériaux-Ruff C, Simonin F, Filliol D, Kieffer BL. Enhanced humoral response in kappa-opioid receptor knockout mice. Journal of Neuroimmunology. 134: 72-81. PMID 12507774 DOI: 10.1016/S0165-5728(02)00419-8  1
2002 Berrendero F, Kieffer BL, Maldonado R. Attenuation of nicotine-induced antinociception, rewarding effects, and dependence in mu-opioid receptor knock-out mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 10935-40. PMID 12486188  1
2002 Halab L, Becker JA, Darula Z, Tourwé D, Kieffer BL, Simonin F, Lubell WD. Probing opioid receptor interactions with azacycloalkane amino acids. Synthesis of a potent and selective ORL1 antagonist. Journal of Medicinal Chemistry. 45: 5353-7. PMID 12431062 DOI: 10.1021/jm020078l  1
2002 Gavériaux-Ruff C, Kieffer BL. Opioid receptor genes inactivated in mice: the highlights. Neuropeptides. 36: 62-71. PMID 12359497 DOI: 10.1054/npep.2002.0900  1
2002 Goody RJ, Oakley SM, Filliol D, Kieffer BL, Kitchen I. Quantitative autoradiographic mapping of opioid receptors in the brain of delta-opioid receptor gene knockout mice. Brain Research. 945: 9-19. PMID 12113946 DOI: 10.1016/S0006-8993(02)02452-6  1
2002 Contarino A, Picetti R, Matthes HW, Koob GF, Kieffer BL, Gold LH. Lack of reward and locomotor stimulation induced by heroin in mu-opioid receptor-deficient mice. European Journal of Pharmacology. 446: 103-9. PMID 12098591 DOI: 10.1016/S0014-2999(02)01812-5  1
2002 Massotte D, Brillet K, Kieffer BL, Milligan G. Agonists activate Gi1α or Gi2α fused to the human mu opioid receptor differently Journal of Neurochemistry. 81: 1372-1382. PMID 12068084 DOI: 10.1046/j.1471-4159.2002.00946.x  1
2002 Kieffer BL, Gavériaux-Ruff C. Exploring the opioid system by gene knockout. Progress in Neurobiology. 66: 285-306. PMID 12015197 DOI: 10.1016/S0301-0082(02)00008-4  1
2002 Kieffer BL, Evans CJ. Opioid tolerance-in search of the holy grail. Cell. 108: 587-90. PMID 11893329 DOI: 10.1016/S0092-8674(02)00666-9  1
2002 Simonin F, Kieffer BL. Two faces for an opioid peptide--and more receptors for pain research. Nature Neuroscience. 5: 185-6. PMID 11865303 DOI: 10.1038/nn0302-185  1
2002 Ghozland S, Matthes HW, Simonin F, Filliol D, Kieffer BL, Maldonado R. Motivational effects of cannabinoids are mediated by mu-opioid and kappa-opioid receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 1146-54. PMID 11826143  1
2001 Sarton E, Teppema LJ, Olievier C, Nieuwenhuijs D, Matthes HW, Kieffer BL, Dahan A. The involvement of the mu-opioid receptor in ketamine-induced respiratory depression and antinociception. Anesthesia and Analgesia. 93: 1495-500, table of c. PMID 11726430  1
2001 Skoubis PD, Matthes HW, Walwyn WM, Kieffer BL, Maidment NT. Naloxone fails to produce conditioned place aversion in mu-opioid receptor knock-out mice. Neuroscience. 106: 757-63. PMID 11682161 DOI: 10.1016/S0306-4522(01)00333-5  1
2001 Zhou L, Rowley DL, Mi QS, Sefcovic N, Matthes HW, Kieffer BL, Donovan DM. Murine inter-strain polymorphisms alter gene targeting frequencies at the mu opioid receptor locus in embryonic stem cells. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 12: 772-8. PMID 11668392 DOI: 10.1007/s00335-001-1003-8  1
2001 Slowe SJ, Clarke S, Lena I, Goody RJ, Lattanzi R, Negri L, Simonin F, Matthes HW, Filliol D, Kieffer BL, Kitchen I. Autoradiographic mapping of the opioid receptor-like 1 (ORL1) receptor in the brains of mu-, delta- or kappa-opioid receptor knockout mice. Neuroscience. 106: 469-80. PMID 11591451 DOI: 10.1016/S0306-4522(01)00308-6  1
2001 Roberts AJ, Gold LH, Polis I, McDonald JS, Filliol D, Kieffer BL, Koob GF. Increased ethanol self-administration in delta-opioid receptor knockout mice. Alcoholism, Clinical and Experimental Research. 25: 1249-56. PMID 11584142  1
2001 Gavériaux-Ruff C, Filliol D, Simonin F, Matthes HW, Kieffer BL. Immunosuppression by delta-opioid antagonist naltrindole: delta- and triple mu/delta/kappa-opioid receptor knockout mice reveal a nonopioid activity. The Journal of Pharmacology and Experimental Therapeutics. 298: 1193-8. PMID 11504820  1
2001 Peluso J, Gavériaux-Ruff C, Matthes HW, Filliol D, Kieffer BL. Orphanin FQ/nociceptin binds to functionally coupled ORL1 receptors on human immune cell lines and alters peripheral blood mononuclear cell proliferation. Brain Research Bulletin. 54: 655-60. PMID 11403992 DOI: 10.1016/S0361-9230(01)00482-8  1
2001 Dahan A, Sarton E, Teppema L, Olievier C, Nieuwenhuijs D, Matthes HW, Kieffer BL. Anesthetic potency and influence of morphine and sevoflurane on respiration in mu-opioid receptor knockout mice. Anesthesiology. 94: 824-32. PMID 11388534  1
2001 Morin-Surun MP, Boudinot E, Dubois C, Matthes HW, Kieffer BL, Denavit-Saubié M, Champagnat J, Foutz AS. Respiratory function in adult mice lacking the mu-opioid receptor: role of delta-receptors. The European Journal of Neuroscience. 13: 1703-10. PMID 11359522 DOI: 10.1046/j.0953-816x.2001.01547.x  1
2001 Maldonado R, Severini C, Matthes HW, Kieffer BL, Melchiorri P, Negri L. Activity of mu- and delta-opioid agonists in vas deferens from mice deficient in MOR gene. British Journal of Pharmacology. 132: 1485-92. PMID 11264242 DOI: 10.1038/sj.bjp.0703966  1
2001 Simonin F, Slowe S, Becker JA, Matthes HW, Filliol D, Chluba J, Kitchen I, Kieffer BL. Analysis of [3H]bremazocine binding in single and combinatorial opioid receptor knockout mice. European Journal of Pharmacology. 414: 189-95. PMID 11239918 DOI: 10.1016/S0014-2999(01)00822-6  1
2001 Hutcheson DM, Matthes HW, Valjent E, Sánchez-Blázquez P, Rodríguez-Díaz M, Garzón J, Kieffer BL, Maldonado R. Lack of dependence and rewarding effects of deltorphin II in mu-opioid receptor-deficient mice. The European Journal of Neuroscience. 13: 153-61. PMID 11135013 DOI: 10.1046/j.1460-9568.2001.01363.x  1
2001 Befort K, Filliol D, Decaillot FM, Gaveriaux-Ruff C, Hoehe MR, Kieffer BL. A single nucleotide polymorphic mutation in the human mu-opioid receptor severely impairs receptor signaling. The Journal of Biological Chemistry. 276: 3130-7. PMID 11067846 DOI: 10.1074/jbc.M006352200  1
2000 Kieffer BL. Opioid receptors: from genes to mice. The Journal of Pain : Official Journal of the American Pain Society. 1: 45-50. PMID 14622842 DOI: 10.1054/jpai.2000.9823  1
2000 Bigoni R, Rizzi A, Rizzi D, Becker JA, Kieffer BL, Simonin F, Regoli D, Calo G. In vitro pharmacological profile of peptide III-BTD: a novel ligand for nociceptin/orphanin FQ and opioid receptors. Life Sciences. 68: 233-9. PMID 11191640  1
2000 Roberts AJ, McDonald JS, Heyser CJ, Kieffer BL, Matthes HW, Koob GF, Gold LH. mu-Opioid receptor knockout mice do not self-administer alcohol. The Journal of Pharmacology and Experimental Therapeutics. 293: 1002-8. PMID 10869404  1
2000 Filliol D, Ghozland S, Chluba J, Martin M, Matthes HW, Simonin F, Befort K, Gavériaux-Ruff C, Dierich A, LeMeur M, Valverde O, Maldonado R, Kieffer BL. Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses. Nature Genetics. 25: 195-200. PMID 10835636 DOI: 10.1038/76061  1
2000 Monory K, Bourin MC, Spetea M, Tömböly C, Tóth G, Matthes HW, Kieffer BL, Hanoune J, Borsodi A. Specific activation of the mu opioid receptor (MOR) by endomorphin 1 and endomorphin 2. The European Journal of Neuroscience. 12: 577-84. PMID 10712637 DOI: 10.1046/j.1460-9568.2000.00936.x  1
1999 Becker JA, Wallace A, Garzon A, Ingallinella P, Bianchi E, Cortese R, Simonin F, Kieffer BL, Pessi A. Ligands for kappa-opioid and ORL1 receptors identified from a conformationally constrained peptide combinatorial library. The Journal of Biological Chemistry. 274: 27513-22. PMID 10488086 DOI: 10.1074/jbc.274.39.27513  1
1999 Befort K, Zilliox C, Filliol D, Yue S, Kieffer BL. Constitutive activation of the delta opioid receptor by mutations in transmembrane domains III and VII. The Journal of Biological Chemistry. 274: 18574-81. PMID 10373467 DOI: 10.1074/jbc.274.26.18574  1
1999 Kieffer BL. Opioids: first lessons from knockout mice. Trends in Pharmacological Sciences. 20: 19-26. PMID 10101958 DOI: 10.1016/S0165-6147(98)01279-6  1
1999 Stanasila L, Massotte D, Kieffer BL, Pattus F. Expression of delta, kappa and mu human opioid receptors in Escherichia coli and reconstitution of the high-affinity state for agonist with heterotrimeric G proteins. European Journal of Biochemistry / Febs. 260: 430-8. PMID 10095778 DOI: 10.1046/j.1432-1327.1999.00187.x  1
1998 Massotte D, Kieffer BL. A molecular basis for opiate action. Essays in Biochemistry. 33: 65-77. PMID 10488442  1
1998 Matthes HW, Smadja C, Valverde O, Vonesch JL, Foutz AS, Boudinot E, Denavit-Saubié M, Severini C, Negri L, Roques BP, Maldonado R, Kieffer BL. Activity of the delta-opioid receptor is partially reduced, whereas activity of the kappa-receptor is maintained in mice lacking the mu-receptor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 7285-95. PMID 9736649  1
1998 Gavériaux-Ruff C, Matthes HW, Peluso J, Kieffer BL. Abolition of morphine-immunosuppression in mice lacking the mu-opioid receptor gene. Proceedings of the National Academy of Sciences of the United States of America. 95: 6326-30. PMID 9600964 DOI: 10.1073/pnas.95.11.6326  1
1998 Peluso J, LaForge KS, Matthes HW, Kreek MJ, Kieffer BL, Gavériaux-Ruff C. Distribution of nociceptin/orphanin FQ receptor transcript in human central nervous system and immune cells. Journal of Neuroimmunology. 81: 184-92. PMID 9521621 DOI: 10.1016/S0165-5728(97)00178-1  1
1998 Simonin F, Valverde O, Smadja C, Slowe S, Kitchen I, Dierich A, Le Meur M, Roques BP, Maldonado R, Kieffer BL. Disruption of the kappa-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa-agonist U-50,488H and attenuates morphine withdrawal. The Embo Journal. 17: 886-97. PMID 9463367 DOI: 10.1093/emboj/17.4.886  1
1998 Valverde O, Maldonado R, Kieffer BL. Recent findings on the mechanism of action of morphine: Implications for the development of new analgesics Cns Drugs. 10: 1-10. DOI: 10.2165/00023210-199810010-00001  1
1998 Hoehe MR, Wendel B, Köpke K, Flachmeier C, Kieffer BL, Berrettini WH, Church GM. Genetic variability of the human mu opioid receptor gene and its implication for substance abuse American Journal of Medical Genetics - Neuropsychiatric Genetics. 81: 507.  1
1997 Kovoor A, Nappey V, Kieffer BL, Chavkin C. Mu and delta opioid receptors are differentially desensitized by the coexpression of beta-adrenergic receptor kinase 2 and beta-arrestin 2 in xenopus oocytes. The Journal of Biological Chemistry. 272: 27605-11. PMID 9346897 DOI: 10.1074/jbc.272.44.27605  1
1997 Gavériaux-Ruff C, Peluso J, Befort K, Simonin F, Zilliox C, Kieffer BL. Detection of opioid receptor mRNA by RT-PCR reveals alternative splicing for the delta- and kappa-opioid receptors. Brain Research. Molecular Brain Research. 48: 298-304. PMID 9332727 DOI: 10.1016/S0169-328X(97)00109-5  1
1997 Arttamangkul S, Ishmael JE, Murray TF, Grandy DK, DeLander GE, Kieffer BL, Aldrich JV. Synthesis and opioid activity of conformationally constrained dynorphin A analogues. 2. Conformational constraint in the "address" sequence. Journal of Medicinal Chemistry. 40: 1211-8. PMID 9111295 DOI: 10.1021/jm960753p  1
1997 Befort K, Kieffer BL. Structure-activity relationships in the δ-opioid receptor Pain Reviews. 4: 100-121.  1
1996 Befort K, Tabbara L, Kieffer BL. [35S]GTP gamma S binding: a tool to evaluate functional activity of a cloned opioid receptor transiently expressed in COS cells. Neurochemical Research. 21: 1301-7. PMID 8947920  1
1996 Matthes HW, Maldonado R, Simonin F, Valverde O, Slowe S, Kitchen I, Befort K, Dierich A, Le Meur M, Dollé P, Tzavara E, Hanoune J, Roques BP, Kieffer BL. Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene. Nature. 383: 819-23. PMID 8893006 DOI: 10.1038/383819a0  1
1996 Befort K, Tabbara L, Kling D, Maigret B, Kieffer BL. Role of aromatic transmembrane residues of the delta-opioid receptor in ligand recognition. The Journal of Biological Chemistry. 271: 10161-8. PMID 8626577 DOI: 10.1074/jbc.271.17.10161  1
1995 Kieffer BL. Recent advances in molecular recognition and signal transduction of active peptides: receptors for opioid peptides. Cellular and Molecular Neurobiology. 15: 615-35. PMID 8719033 DOI: 10.1007/BF02071128  1
1995 Pei G, Kieffer BL, Lefkowitz RJ, Freedman NJ. Agonist-dependent phosphorylation of the mouse delta-opioid receptor: involvement of G protein-coupled receptor kinases but not protein kinase C. Molecular Pharmacology. 48: 173-7. PMID 7651349  1
1994 Kieffer BL, Befort K, Gavériaux-Ruff C, Hirth CG. The delta-opioid receptor: isolation of a cDNA by expression cloning and pharmacological characterization. Proceedings of the National Academy of Sciences of the United States of America. 91: 1193. PMID 8302853  1
1994 Kieffer BL, Befort K, Gavériaux-Ruff C, Mattéi MG, Hirth C. Expression cloning of a murine delta opioid receptor Regulatory Peptides. 53: S1-S2. DOI: 10.1016/0167-0115(94)90211-9  1
1994 Simon EJ, Evans CJ, Kieffer BL, Childers SR, Uhl G, Yu L. Opioid receptors: Molecular and structural studies Nida Research Monograph Series. 46-50.  1
1993 Dascal N, Schreibmayer W, Lim NF, Wang W, Chavkin C, DiMagno L, Labarca C, Kieffer BL, Gaveriaux-Ruff C, Trollinger D. Atrial G protein-activated K+ channel: expression cloning and molecular properties. Proceedings of the National Academy of Sciences of the United States of America. 90: 10235-9. PMID 8234283  1
1992 Kieffer BL, Befort K, Gaveriaux-Ruff C, Hirth CG. The delta-opioid receptor: isolation of a cDNA by expression cloning and pharmacological characterization. Proceedings of the National Academy of Sciences of the United States of America. 89: 12048-52. PMID 1334555  0.68
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